KR20200044138A - 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도 - Google Patents

알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도 Download PDF

Info

Publication number
KR20200044138A
KR20200044138A KR1020207011059A KR20207011059A KR20200044138A KR 20200044138 A KR20200044138 A KR 20200044138A KR 1020207011059 A KR1020207011059 A KR 1020207011059A KR 20207011059 A KR20207011059 A KR 20207011059A KR 20200044138 A KR20200044138 A KR 20200044138A
Authority
KR
South Korea
Prior art keywords
aat
leu
disease
syndrome
lys
Prior art date
Application number
KR1020207011059A
Other languages
English (en)
Korean (ko)
Inventor
찰스 에이. 디나렐로
김수현
Original Assignee
더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트
건국대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트, 건국대학교 산학협력단 filed Critical 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트
Publication of KR20200044138A publication Critical patent/KR20200044138A/ko

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
KR1020207011059A 2011-06-24 2012-06-22 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도 KR20200044138A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161500795P 2011-06-24 2011-06-24
US61/500,795 2011-06-24
PCT/US2012/043869 WO2012178102A2 (fr) 2011-06-24 2012-06-22 Compositions, procédés et utilisations de molécules de fusion de l'alpha-1 antitrypsine

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020147001915A Division KR102103476B1 (ko) 2011-06-24 2012-06-22 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도

Publications (1)

Publication Number Publication Date
KR20200044138A true KR20200044138A (ko) 2020-04-28

Family

ID=47423247

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020147001915A KR102103476B1 (ko) 2011-06-24 2012-06-22 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도
KR1020207011059A KR20200044138A (ko) 2011-06-24 2012-06-22 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020147001915A KR102103476B1 (ko) 2011-06-24 2012-06-22 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도

Country Status (7)

Country Link
US (4) US9938353B2 (fr)
EP (2) EP2723370A4 (fr)
JP (4) JP6216921B2 (fr)
KR (2) KR102103476B1 (fr)
AU (4) AU2012272636A1 (fr)
CA (1) CA2839917A1 (fr)
WO (1) WO2012178102A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2520654T3 (pl) 2003-08-26 2017-08-31 The Regents Of The University Of Colorado, A Body Corporate Inhibitory aktywności proteazy serynowej i ich zastosowanie w sposobach i kompozycjach do leczenia zakażeń bakteryjnych
CA2839917A1 (fr) * 2011-06-24 2012-12-27 The Regents Of The University Of Colorado, A Body Corporate Compositions, procedes et utilisations de molecules de fusion de l'alpha-1 antitrypsine
US10400029B2 (en) 2011-06-28 2019-09-03 Inhibrx, Lp Serpin fusion polypeptides and methods of use thereof
IN2013MN02441A (fr) 2011-06-28 2015-06-12 Inhibrx Llc
KR20140137347A (ko) * 2012-01-10 2014-12-02 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도
EP3708182A1 (fr) * 2013-03-29 2020-09-16 The Regents Of The University Of Colorado Compositions et méthodes pour préparer un sujet à l'implantation d'un organe ou d'un non-organe
WO2014184794A1 (fr) * 2013-05-15 2014-11-20 Mor Research Applications Ltd. Compositions et méthodes pour traiter des complications post-opératoires de la chirurgie cardiopulmonaire
EP4219534A3 (fr) 2013-07-08 2023-09-27 The University of Utah Research Foundation Procédés de traitement et de prophylatise contre les troubles inflammatoires
JP6372562B2 (ja) * 2014-03-19 2018-08-15 株式会社安川電機 回転電機
US20170190762A1 (en) * 2014-06-11 2017-07-06 Beth Israel Deaconess Medical Center, Inc. Alpha1 -antitrypsin compositions and methods of treating autoimmune diseases
US20180050082A1 (en) * 2015-03-10 2018-02-22 Anvil Biosciences, Llc Serpins for the treatment of neuroinflammatory diseases
EP3585423A4 (fr) * 2017-02-21 2020-12-23 Kamada Ltd. Procédés et utilisations de l'alpha 1-antitrypsine pour une intervention précoce dans des maladies pulmonaires
EP4321220A3 (fr) * 2017-12-01 2024-03-20 CSL Behring LLC A1at permettant de réduire le risque d'apparition d'une maladie aiguë du greffon contre l'hôte après une transplantation de cellules hématopoïétiques
EP3802587A4 (fr) * 2018-06-07 2022-03-23 Prottech Inc. Composition pharmaceutique comprenant une protéine fusion et utilisation associée
CN109251936B (zh) * 2018-09-20 2021-09-10 四川理工学院 一种光滑鳖甲丝氨酸蛋白酶抑制剂融合蛋白及制备与应用
CA3168807A1 (fr) * 2020-01-30 2021-08-05 Vertex Pharmaceuticals Incorporated Procedes de traitement d'une deficience en alpha-1 antitrypsine
WO2021178448A1 (fr) * 2020-03-02 2021-09-10 Motor Life Sciences, Llc Compositions et méthodes de diagnostic, de prévention et de traitement de la sclérose latérale amyotrophique chez des patients présentant une activité anti-trypsine hypofonctionnelle
WO2023198757A1 (fr) * 2022-04-14 2023-10-19 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Alpha-1-antitrypsine pour le traitement d'infections à paramyxoviridae ou orthomyxoviridae

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874424A (en) 1995-12-20 1999-02-23 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
GB1472700A (en) 1974-11-01 1977-05-04 Ono Pharmaceutical Co Guanidinobehzoic acid derivatives and process for preparing the same
JPS5470241A (en) 1977-11-09 1979-06-05 Ono Pharmaceut Co Ltd Guanidinobenzoic acid derivative and its preparation
GB2044760B (en) 1979-03-01 1983-03-23 Ono Pharmaceutical Co Guanidinobenzoic acid derivatives
US4215051A (en) 1979-08-29 1980-07-29 Standard Oil Company (Indiana) Formation, purification and recovery of phthalic anhydride
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
AU577259B2 (en) * 1982-08-13 1988-09-22 Zymogenetics Inc. Glycolytic promters for regulated protein expression protease inhibitor
US4711848A (en) 1984-03-14 1987-12-08 Zymogenetics, Inc. Site specific mutagenesis in alpha-1-antitrypsin
WO1986000337A1 (fr) 1984-06-19 1986-01-16 Transgene S.A. DERIVES DE L'alpha1-ANTITRYPSINE HUMAINE ET PROCEDE POUR LEUR PREPARATION
US4629567A (en) 1986-03-07 1986-12-16 Smithkline-Rit Alpha-1-antiprotease purification
US5157019A (en) 1986-03-18 1992-10-20 Monsanto Company Serine protease inhibitors
US4829052A (en) 1986-06-11 1989-05-09 Monsanto Company Serine protease inhibitors
US5008242A (en) 1986-12-24 1991-04-16 John Lezdey Treatment of inflammation using 1-antichymotrypsin
US5114917A (en) 1986-12-24 1992-05-19 John Lezdey Treatment of inflammation using alpha 1-antichymotrypsin
US4829054A (en) 1987-04-13 1989-05-09 Miles Laboratories, Inc. Method of decreasing lung damage in a host following the onset of gram negative septicemia/endotoxemia
US4857538A (en) 1987-11-30 1989-08-15 The Research Foundation Of State University Of New York New compounds for the study and treatment of microfilament organization in cells
US4963654A (en) 1989-02-13 1990-10-16 Taisho Pharmaceutical Co., Ltd. Peptide serine protease inhibitor
US5116964A (en) 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
US5225538A (en) 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
GB8909916D0 (en) * 1989-04-29 1989-06-14 Delta Biotechnology Ltd Polypeptides
US5612194A (en) 1989-06-23 1997-03-18 Trustees Of The University Of Pennsylvania Methods of producing effective recombinant serine protease inhibitors and uses of these inhibitors
US5714140A (en) 1989-12-13 1998-02-03 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting the production of bioactive IL-1 by administering M-CSF
WO1992006706A1 (fr) 1990-10-16 1992-04-30 John Lezdey Traitement d'inflammations
US5134119A (en) 1990-10-16 1992-07-28 Lezdey John Treatment of inflammation using 358 substituted alpha-antitrypsin
US5470970A (en) 1991-02-28 1995-11-28 Dana-Farber Cancer Institute, Inc. Maspin, a serpin with tumor suppresing activity
WO1992018141A1 (fr) 1991-04-18 1992-10-29 The Uab Research Foundation Compositions et procedes d'inhibition de l'elastase
US5175253A (en) 1991-04-24 1992-12-29 Washington University Binding peptides
GB9115364D0 (en) 1991-07-16 1991-08-28 Wellcome Found Antibody
US5216022A (en) 1991-12-19 1993-06-01 Cortech, Inc. Aromatic esters of phenylenedialkanoates as inhibitors of human neutrophil elastase
WO1993018794A1 (fr) 1992-03-26 1993-09-30 Gensia, Inc. Therapie in vivo recourant a des peptides
GB9209032D0 (en) * 1992-04-25 1992-06-10 Ciba Geigy Ag New peptide derivatives
US5734014A (en) 1992-08-11 1998-03-31 Tsumura & Co. Elafin derivative
US5604201A (en) 1993-01-08 1997-02-18 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non-Profit Organization Methods and reagents for inhibiting furin endoprotease
US5346886A (en) 1993-11-15 1994-09-13 John Lezdey Topical α-1-antitrypsin, non-aqueous lipid miscible, benzalkonium chloride compositions for treating skin
JPH0827371A (ja) 1994-05-09 1996-01-30 Japan Carlit Co Ltd:The 紫外線及び赤外線吸収樹脂組成物
EP0764151A2 (fr) 1994-06-10 1997-03-26 Universitaire Instelling Antwerpen Purification de proteases serines, et leurs inhibiteurs synthetiques
US5610285A (en) 1994-08-24 1997-03-11 Bayer Corporation Purification of α-1 proteinase inhibitor using novel chromatographic separation conditions
US5514653A (en) 1994-09-09 1996-05-07 Washington University Method of blocking the SEC receptor
US5618792A (en) 1994-11-21 1997-04-08 Cortech, Inc. Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
US5712117A (en) 1995-02-08 1998-01-27 Zymogenetics, Inc. Cytoplasmic antiproteinase-2 and coding sequences
DE69637307T2 (de) 1995-11-28 2008-02-28 Cephalon, Inc. Aus d-aminosäuren abgeleitete cystein-und serinproteasehemmer
US6136834A (en) 1995-12-27 2000-10-24 Ono Pharmaceutical Co., Ltd. Tetrazole compounds and pharmaceutical agents containing such derivative
BR9708021A (pt) 1996-03-11 1999-07-27 Bayer Ag Proteína substancialmente purificada composição farmacêutica sequência de ácido nucleico isolada vetor de express o de protéina auto-replicante e processos para inibir a atividade de protéinas de serina tratar uma condição e preparar um medicamento de uma proteína
US6072041A (en) 1996-06-03 2000-06-06 Case Western Reserve University Fusion proteins for protein delivery
US5780440A (en) 1996-06-17 1998-07-14 Protease Sciences Inc. Treatment of pulmonary disease with protease inhibitors
US5616693A (en) 1996-07-01 1997-04-01 Alpha Therapeutic Corporation Process for seperating alpha-1-proteinase inhibitor from COHN IV1 +1V4 paste
US7147851B1 (en) 1996-08-15 2006-12-12 Millennium Pharmaceuticals, Inc. Humanized immunoglobulin reactive with α4β7 integrin
PT1864999E (pt) 1996-11-27 2009-06-25 Genentech Inc Purificação por afinidade de um polipéptido numa matriz de proteína a
HUP0100669A3 (en) 1996-12-06 2001-12-28 Cortech Inc Denver Peptide derivatives as serine protease inhibitors, their use and pharmaceutical compositions comprising thereof
US6150332A (en) * 1997-01-09 2000-11-21 Virginia Commonwealth University Method and composition for lowering low density lipoprotein cholesterol
US6124257A (en) 1997-08-28 2000-09-26 Lezdey; John Method of treatment
US7279459B2 (en) 2001-01-04 2007-10-09 Vascular Biogenics Ltd. Methods employing and compositions containing plaque associated molecules for prevention and treatment of atherosclerosis
US6197294B1 (en) 1998-10-26 2001-03-06 Neurotech S.A. Cell surface molecule-induced macrophage activation
WO2000044390A1 (fr) 1999-02-01 2000-08-03 John Lezdey Traitement de la mastocytose gastro-intestinale et de la vessie
GB9904421D0 (en) 1999-02-25 1999-04-21 Univ Edinburgh Telecommunications receiver
AU3609300A (en) * 1999-03-01 2000-09-21 Human Genome Sciences, Inc. Human serpin proteins
US6489308B1 (en) 1999-03-05 2002-12-03 Trustees Of University Of Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of nitric-oxide-induced clinical conditions
WO2000051625A1 (fr) 1999-03-05 2000-09-08 The Trustees Of University Technology Corporation Inhibiteurs d'activite de serine protease, methodes et compositions de traitement de virus de l'herpes
AU3719100A (en) 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Inhibitors of serine protease activity, methods and compositions for treatment of viral infections
AU3731400A (en) 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Methods and compositions useful in inhibiting apoptosis
US6849605B1 (en) 1999-03-05 2005-02-01 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of viral infections
US6174859B1 (en) 1999-04-06 2001-01-16 J & D Sciences, Inc. Method of treatment
ES2317843T3 (es) 1999-07-13 2009-05-01 Bolder Biotechnology, Inc. Proteinas de fusion de eritropoyetina-inmunoglobulina.
AU2050501A (en) 1999-12-01 2001-06-12 Human Genome Sciences, Inc. Four disulfide core domain-containing (fdcd) polynucleotides, polypeptides, and antibodies
US6955845B1 (en) 2000-06-30 2005-10-18 Owens Corning Fiberglas Technology, Inc. Acoustical and thermal insulator
PT1355919E (pt) 2000-12-12 2011-03-02 Medimmune Llc Moléculas com semivida longa, composições que as contêm e suas utilizações
US7247704B2 (en) 2000-12-18 2007-07-24 Arriva Pharmaceuticals, Inc. Multifunctional protease inhibitors and their use in treatment of disease
PL374045A1 (en) 2001-02-23 2005-09-19 Immunex Corporation Efficient recovery of correctly refolded proteins
AU2002335930B2 (en) 2001-03-09 2005-07-28 Morphosys Ag Serum albumin binding moieties
CA2448253A1 (fr) 2001-05-25 2002-11-28 Genset S.A. Adnc et proteines humaines, ainsi que leurs utilisations
CA2451026C (fr) 2001-06-22 2013-12-10 Health Protection Agency Antigenes mycobacteriens exprimes sous faible tension en oxygene
US7270960B2 (en) 2001-08-29 2007-09-18 Pacific Northwest Research Institute Diagnosis of ovarian carcinomas
US6924267B2 (en) 2001-09-18 2005-08-02 Suomen Punainen Risti Veripalvelu Methods and active substances for protecting organs
US6797493B2 (en) 2001-10-01 2004-09-28 Lee-Hwei K. Sun Fc fusion proteins of human granulocyte colony-stimulating factor with increased biological activities
AU2002359816B2 (en) 2001-12-21 2006-07-13 Immunex Corporation Methods for purifying protein
CN101044154A (zh) 2002-02-14 2007-09-26 威廉·J·鲁特 治疗宿主中切割的嵌合分子
PT1551834E (pt) 2002-05-23 2010-09-30 Novartis Vaccines & Diagnostic Compostos de quinazolinona substituídos
WO2004010989A1 (fr) 2002-07-25 2004-02-05 Advances Life Sciences, Inc. Utilisation des acides 2,3 alkylcarbonyloxybenzoiques, de leurs derives et analogues pour le traitement des tissus et de dysfonctionnements, alterations et lesions cellulaires chez les mammiferes
US20040220242A1 (en) 2003-05-02 2004-11-04 Leland Shapiro Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions
PL2520654T3 (pl) 2003-08-26 2017-08-31 The Regents Of The University Of Colorado, A Body Corporate Inhibitory aktywności proteazy serynowej i ich zastosowanie w sposobach i kompozycjach do leczenia zakażeń bakteryjnych
WO2005046454A2 (fr) 2003-11-12 2005-05-26 Trustrees Of The University Of Pennsylvania Procedes d'utilisation de la gelsoline pour traiter ou prevenir la sepsie bacterienne
JP4870569B2 (ja) * 2003-11-13 2012-02-08 ハンミ ホールディングス カンパニー リミテッド 免疫グロブリン断片を用いた蛋白質結合体およびその製造方法
KR101314461B1 (ko) 2004-05-12 2013-10-07 더 브리검 앤드 우먼즈 하스피털, 인크. 감염 치료를 위한 겔솔린의 용도
US8715649B2 (en) * 2005-06-07 2014-05-06 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods of use for alpha-1 antitrypsin having no significant serine protease inhibitor activity
CA2654446C (fr) * 2005-06-07 2014-02-25 The Regents Of The University Of Colorado Inhibiteurs de l'activite serine protease et leur utilisation dans des procedes et compositions pour le traitement du rejet du greffon et la promotion de la survie du greffon
CA2671322A1 (fr) 2005-12-02 2007-07-12 Regents Of The University Of Colorado Compositions et methodes pour le traitement de problemes medicaux medies par l'actine au moyen d'un agent modulant l'actine
US8623830B2 (en) 2006-09-12 2014-01-07 Beth Israel Deaconess Medical Center, Inc. Compositions containing α-1-antitrypsin and methods for use
AR063975A1 (es) * 2006-11-28 2009-03-04 Centelion Fusiones fc con receptor para fgf soluble modificadas con actividad biologica mejorada
WO2008100470A2 (fr) 2007-02-15 2008-08-21 Transtech Pharma, Inc. Protéines de fusion de l'immunoglobuline et procédés de fabrication
EP2148693A4 (fr) 2007-04-20 2010-06-02 Univ Colorado Antitrypsine alpha-1 n'ayant pas d'activité inhibitrice de sérine protéase significative
WO2008138017A2 (fr) * 2007-05-08 2008-11-13 Beth Israel Deaconess Medical Center, Inc. Procédés et compositions permettant de modifier des réponses immunitaires de lymphocyte t et l'inflammation
WO2009006520A1 (fr) 2007-07-03 2009-01-08 Medimmune, Llc Ingénierie de domaine charnière
WO2009015345A1 (fr) 2007-07-25 2009-01-29 Amgen Inc. Compositions pharmaceutiques comprenant des protéines de fusion fc
KR100992526B1 (ko) * 2007-11-21 2010-11-05 한국과학기술연구원 이황화결합을 이용한 내열성의 알파-1-안티트립신 뮤테인및 그의 제조방법
EP2080812A1 (fr) 2008-01-18 2009-07-22 Transmedi SA Compositions et procédés pour détecter des peptides post-stop
EP2423233B1 (fr) 2009-04-22 2015-03-11 Alteogen, Inc Protéine ou peptide de fusion dont la demi-vie est augmentée par le maintien de la libération prolongée in vivo, et procédé d'augmentation de la demi-vie in vivo en l'utilisant
WO2011102845A1 (fr) 2010-02-18 2011-08-25 Transtech Pharma, Inc. Compositions de protéines de fusion rage et méthodes d'utilisation
CA2839917A1 (fr) 2011-06-24 2012-12-27 The Regents Of The University Of Colorado, A Body Corporate Compositions, procedes et utilisations de molecules de fusion de l'alpha-1 antitrypsine
IN2013MN02441A (fr) 2011-06-28 2015-06-12 Inhibrx Llc
KR20140068861A (ko) 2011-06-28 2014-06-09 인히브릭스 엘엘씨 Wap 도메인 융합 폴리펩티드 및 이의 이용 방법

Also Published As

Publication number Publication date
US20220204646A1 (en) 2022-06-30
KR20140096257A (ko) 2014-08-05
AU2012272636A1 (en) 2013-05-02
US20140341899A1 (en) 2014-11-20
EP2723370A2 (fr) 2014-04-30
AU2016202734A1 (en) 2016-05-19
KR102103476B1 (ko) 2020-04-23
AU2019257412B2 (en) 2022-01-06
WO2012178102A2 (fr) 2012-12-27
AU2018200571B2 (en) 2019-11-21
US20180208681A1 (en) 2018-07-26
EP2723370A4 (fr) 2015-06-03
JP2014519852A (ja) 2014-08-21
WO2012178102A3 (fr) 2013-03-28
US20200109215A1 (en) 2020-04-09
CA2839917A1 (fr) 2012-12-27
AU2018200571C1 (en) 2020-04-23
AU2019257412A1 (en) 2019-11-14
US10450384B2 (en) 2019-10-22
JP2017079769A (ja) 2017-05-18
JP2020171316A (ja) 2020-10-22
US9938353B2 (en) 2018-04-10
AU2018200571A1 (en) 2018-02-15
JP6216921B2 (ja) 2017-11-01
JP2019058197A (ja) 2019-04-18
EP3628327A1 (fr) 2020-04-01

Similar Documents

Publication Publication Date Title
AU2019257412B2 (en) Compositions, methods and uses for alpha-1 antitrypsin fusion molecules
AU2021202131B2 (en) Serpin fusion polypeptides and methods of use thereof
CN107880136B (zh) 多聚体il-15可溶性融合分子与其制造与使用方法
US20180250416A1 (en) Compositions, methods and uses for alpha-1 antitrypsin fusion molecules
TW201010715A (en) FGF21 mutants and uses thereof
AU2015339507B2 (en) Serpin fusion polypeptides and methods of use thereof
US20200115437A1 (en) Serpin fusion polypeptides and methods of use thereof
CN113286816A (zh) 用于α-1-抗胰蛋白酶病症的组合物和方法
AU2020203749B2 (en) Variants Of Tissue Inhibitor Of Metalloproteinase Type Three (TIMP-3), Compositions And Methods
CN113398242B (zh) 一种抗体耦联药物及其应用
CN116333055A (zh) 一类靶向covid-19病毒s蛋白的超高亲和力小蛋白及用途
KR20230142722A (ko) 시알리다제-pd-1-항체 융합 단백질들 및 이의 사용방법

Legal Events

Date Code Title Description
A107 Divisional application of patent
E902 Notification of reason for refusal
E601 Decision to refuse application