KR20200037796A - 암 치료를 위한 염색체 불안정성 및 다운스트림 사이토졸 dna 시그널링의 표적화 - Google Patents
암 치료를 위한 염색체 불안정성 및 다운스트림 사이토졸 dna 시그널링의 표적화 Download PDFInfo
- Publication number
- KR20200037796A KR20200037796A KR1020207003861A KR20207003861A KR20200037796A KR 20200037796 A KR20200037796 A KR 20200037796A KR 1020207003861 A KR1020207003861 A KR 1020207003861A KR 20207003861 A KR20207003861 A KR 20207003861A KR 20200037796 A KR20200037796 A KR 20200037796A
- Authority
- KR
- South Korea
- Prior art keywords
- cells
- cell
- cgamp
- sample
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/04—Nitro compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762530661P | 2017-07-10 | 2017-07-10 | |
| US62/530,661 | 2017-07-10 | ||
| PCT/US2018/041480 WO2019014246A1 (en) | 2017-07-10 | 2018-07-10 | TARGETING CHROMOSOMIC INSTABILITY AND SIGNALING OF CYTOSOLIC DNA IN AVAL FOR THE TREATMENT OF CANCER |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20200037796A true KR20200037796A (ko) | 2020-04-09 |
Family
ID=63036469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020207003861A Withdrawn KR20200037796A (ko) | 2017-07-10 | 2018-07-10 | 암 치료를 위한 염색체 불안정성 및 다운스트림 사이토졸 dna 시그널링의 표적화 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11821042B2 (enExample) |
| EP (1) | EP3652349A1 (enExample) |
| JP (1) | JP7197556B2 (enExample) |
| KR (1) | KR20200037796A (enExample) |
| CN (1) | CN111295454A (enExample) |
| AU (1) | AU2018300007A1 (enExample) |
| BR (1) | BR112020000477A2 (enExample) |
| CA (1) | CA3069515A1 (enExample) |
| IL (1) | IL271849A (enExample) |
| MX (1) | MX2020000406A (enExample) |
| SG (1) | SG11202000132WA (enExample) |
| WO (1) | WO2019014246A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017318610B2 (en) * | 2016-09-02 | 2021-12-09 | The Board Of Trustees Of The University Of Illinois | KIF13B-derived peptide and method of inhibiting Angiogenesis |
| BR112020000477A2 (pt) | 2017-07-10 | 2020-07-21 | Cornell University | ataque à instabilidade cromossômica e sinalização de dna citosólico a jusante para tratamento de câncer |
| JP7226763B2 (ja) * | 2017-08-17 | 2023-02-21 | 国立大学法人山口大学 | 癌幹細胞における薬物耐性の低減剤、癌幹細胞における転移能の抑制剤及び癌の転移性再発リスクを予測する方法 |
| EP3987291A1 (en) * | 2019-06-21 | 2022-04-27 | IFM Due, Inc. | Methods of treating cancer |
| EP4110343B1 (en) * | 2020-02-19 | 2026-04-08 | Instituto De Biologia Molecular E Celular - IBMC | 4-pyrrolidin-1-yl-5-p-tolyl-thieno[2,3-d] pyrimidine for use in the treatment of aging-associated and premature aging diseases through restored chromosomal stability and inhibition of cellular senescence |
| EP4160181A4 (en) * | 2020-05-28 | 2024-08-07 | Wang, Daoxiang | METHOD FOR PREPARING MULTIPLE STAINING SECTIONS FOR A CYTOPATHOLOGY SAMPLE |
| US20230324392A1 (en) * | 2020-09-02 | 2023-10-12 | Memorial Sloan Kettering Cancer Center | Methods and compositions for targeting cytosolic dsdna signaling in chromosomally unstable cancers |
| EP4326726A4 (en) * | 2021-04-23 | 2025-03-26 | Baruch S. Blumberg Institute | METHODS, KITS AND COMPOSITIONS FOR REDUCING CHROMOSOMALIC INSTABILITY IN CANCER CELLS |
| CN113341154B (zh) * | 2021-05-14 | 2024-11-05 | 医工瑞思(福建)工程研究中心有限公司 | 一种检测血栓或凝血相关疾病的生物标志物及其应用 |
| WO2023028564A1 (en) | 2021-08-26 | 2023-03-02 | Volastra Therapeutics, Inc. | Spiro indoline inhibitors of kif18a |
| CN115354078B (zh) * | 2022-09-02 | 2023-07-07 | 中山大学附属第一医院 | 骨肉瘤检测标记物及其应用 |
| EP4488389A1 (en) * | 2023-07-05 | 2025-01-08 | Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III (F.S.P. CNIO) | Signature for the prognosis of brain metastasis relapse |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4962091A (en) | 1986-05-23 | 1990-10-09 | Syntex (U.S.A.) Inc. | Controlled release of macromolecular polypeptides |
| WO1994007529A1 (en) | 1992-09-25 | 1994-04-14 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| AU1508899A (en) | 1997-12-02 | 1999-06-16 | Chong Kun Dang Corporation | Pharmaceutical composition comprising cyclosporin solid-state microemulsion |
| GB201121070D0 (en) | 2011-12-07 | 2012-01-18 | Isis Innovation | composition for delivery of biotherapeutics |
| PT2934598T (pt) | 2012-12-19 | 2018-07-24 | Univ Texas | Focalização farmacêutica de uma trajetória de sinalização de dinucleótido cíclico de mamífero |
| WO2015036643A2 (es) | 2013-09-13 | 2015-03-19 | Sierra Jiménez Angels | Marcador para predecir metástasis del cancer de mama |
| BR112016020897A2 (en) * | 2014-03-11 | 2018-01-23 | The Council Of The Queensland Institute Of Medical Research | Determination of cancer aggressiveness, prognosis, and responsiveness to treatment |
| WO2016044790A1 (en) * | 2014-09-19 | 2016-03-24 | Memorial Sloan-Kettering Cancer Center | Methods for treating brain metastasis |
| US10329258B2 (en) | 2015-04-30 | 2019-06-25 | University Of Washington | CGAS in systemic lupus erythematosus (SLE) |
| BR112020000477A2 (pt) | 2017-07-10 | 2020-07-21 | Cornell University | ataque à instabilidade cromossômica e sinalização de dna citosólico a jusante para tratamento de câncer |
-
2018
- 2018-07-10 BR BR112020000477-4A patent/BR112020000477A2/pt not_active Application Discontinuation
- 2018-07-10 KR KR1020207003861A patent/KR20200037796A/ko not_active Withdrawn
- 2018-07-10 MX MX2020000406A patent/MX2020000406A/es unknown
- 2018-07-10 EP EP18746496.1A patent/EP3652349A1/en active Pending
- 2018-07-10 CA CA3069515A patent/CA3069515A1/en active Pending
- 2018-07-10 WO PCT/US2018/041480 patent/WO2019014246A1/en not_active Ceased
- 2018-07-10 AU AU2018300007A patent/AU2018300007A1/en not_active Abandoned
- 2018-07-10 CN CN201880058523.8A patent/CN111295454A/zh active Pending
- 2018-07-10 US US16/629,512 patent/US11821042B2/en active Active
- 2018-07-10 SG SG11202000132WA patent/SG11202000132WA/en unknown
- 2018-07-10 JP JP2020500887A patent/JP7197556B2/ja active Active
-
2020
- 2020-01-06 IL IL271849A patent/IL271849A/en unknown
-
2023
- 2023-04-12 US US18/299,558 patent/US20240110246A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US11821042B2 (en) | 2023-11-21 |
| CA3069515A1 (en) | 2019-01-17 |
| US20240110246A1 (en) | 2024-04-04 |
| CN111295454A (zh) | 2020-06-16 |
| JP7197556B2 (ja) | 2022-12-27 |
| SG11202000132WA (en) | 2020-02-27 |
| WO2019014246A1 (en) | 2019-01-17 |
| AU2018300007A1 (en) | 2020-02-27 |
| JP2020526206A (ja) | 2020-08-31 |
| BR112020000477A2 (pt) | 2020-07-21 |
| MX2020000406A (es) | 2020-10-01 |
| US20210130903A1 (en) | 2021-05-06 |
| IL271849A (en) | 2020-02-27 |
| EP3652349A1 (en) | 2020-05-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20240110246A1 (en) | Targeting chromosomal instability and downstream cytosolic dna signaling for cancer treatment | |
| US12247982B2 (en) | Markers selectively deregulated in tumor-infiltrating regulatory T cells | |
| US11873486B2 (en) | Modulating dsRNA editing, sensing, and metabolism to increase tumor immunity and improve the efficacy of cancer immunotherapy and/or modulators of intratumoral interferon | |
| WO2021247540A1 (en) | Methods for modulating mhc-i expression and immunotherapy uses thereof | |
| CN113260633A (zh) | 用于癌症免疫疗法的诊断方法和组合物 | |
| KR20210040948A (ko) | 단핵구 및 대식세포의 염증성 표현형을 조절하기 위한 조성물 및 방법, 그리고 이의 면역요법 용도 | |
| US20200108066A1 (en) | Methods for modulating regulatory t cells and immune responses using cdk4/6 inhibitors | |
| US11740242B2 (en) | Modulating biomarkers to increase tumor immunity and improve the efficacy of cancer immunotherapy | |
| KR20100095564A (ko) | 항-cd40 항체를 사용한 치료에 대한 b-세포 림프종의 반응성 평가를 위한 방법 및 조성물 | |
| US12005073B2 (en) | Methods for modulating regulatory T cells, regulatory b cells, and immune responses using modulators of the april-taci interaction | |
| US20200300859A1 (en) | Modulating biomarkers to increase tumor immunity and improve the efficacy of cancer immunotherapy | |
| KR20160117606A (ko) | 항-혈관형성 약물에 대한 반응 및 암의 예후를 예측하기 위한 분자적 진단 시험 | |
| US20230105008A1 (en) | Methods and compositions for identifying castration resistant neuroendocrine prostate cancer | |
| WO2018148378A1 (en) | Modulating biomarkers to increase tumor immunity and improve the efficiacy of cancer immunotherapy | |
| CN116583537A (zh) | 与对过继细胞疗法的应答相关的t细胞表型 | |
| US20240280561A1 (en) | Compositions and methods for treating and/or identifying an agent for treating intestinal cancers | |
| US12109266B2 (en) | Modulating gabarap to modulate immunogenic cell death | |
| CA3212132A1 (en) | Methods of treating red blood cell disorders | |
| US20260117178A1 (en) | Means to treat autoimmunity by refining regulatory t cells | |
| CA3023980C (en) | Markers selectively deregulated in tumor-infiltrating regulatory t cells | |
| HK40058894A (en) | Diagnostic methods and compositions for cancer immunotherapy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20200210 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20210709 Comment text: Request for Examination of Application |
|
| PC1202 | Submission of document of withdrawal before decision of registration |
Comment text: [Withdrawal of Procedure relating to Patent, etc.] Withdrawal (Abandonment) Patent event code: PC12021R01D Patent event date: 20231205 |
|
| WITB | Written withdrawal of application |