KR20200026918A - 화학적으로 변형된 백본을 갖는 생체접합체 - Google Patents

화학적으로 변형된 백본을 갖는 생체접합체 Download PDF

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Publication number
KR20200026918A
KR20200026918A KR1020207002776A KR20207002776A KR20200026918A KR 20200026918 A KR20200026918 A KR 20200026918A KR 1020207002776 A KR1020207002776 A KR 1020207002776A KR 20207002776 A KR20207002776 A KR 20207002776A KR 20200026918 A KR20200026918 A KR 20200026918A
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KR
South Korea
Prior art keywords
peptide
bioconjugate
chemically sulfated
glycan
collagen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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KR1020207002776A
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English (en)
Korean (ko)
Inventor
존 에릭 파데리
글렌 프레스트위치
캐서린 앨리슨 스튜어트
하르샤 카브라
엘비스 이콰
Original Assignee
시믹 아이피, 엘엘씨
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Application filed by 시믹 아이피, 엘엘씨 filed Critical 시믹 아이피, 엘엘씨
Publication of KR20200026918A publication Critical patent/KR20200026918A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Polymers & Plastics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
KR1020207002776A 2017-07-07 2018-07-09 화학적으로 변형된 백본을 갖는 생체접합체 Ceased KR20200026918A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762530066P 2017-07-07 2017-07-07
US62/530,066 2017-07-07
PCT/US2018/041280 WO2019010490A1 (en) 2017-07-07 2018-07-09 BIOCONJUGATES WITH CHEMICALLY MODIFIED SKELETONS

Publications (1)

Publication Number Publication Date
KR20200026918A true KR20200026918A (ko) 2020-03-11

Family

ID=64950399

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020207002776A Ceased KR20200026918A (ko) 2017-07-07 2018-07-09 화학적으로 변형된 백본을 갖는 생체접합체

Country Status (7)

Country Link
US (1) US11896642B2 (https=)
EP (1) EP3648775A4 (https=)
JP (2) JP2020526493A (https=)
KR (1) KR20200026918A (https=)
CN (1) CN111050778B (https=)
AU (1) AU2018298226B2 (https=)
WO (1) WO2019010490A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015175565A2 (en) 2014-05-12 2015-11-19 Purdue Research Foundation Selectin and icam/vcam peptide ligand conjugates
AU2018298224B2 (en) 2017-07-07 2024-08-15 Symic Ip, Llc Synthetic bioconjugates
CN113490517B (zh) * 2021-04-27 2022-04-19 北京博辉瑞进生物科技有限公司 一种嵌合肽修饰的sis膜、其制备方法及应用
WO2022227225A1 (zh) * 2021-04-27 2022-11-03 北京博辉瑞进生物科技有限公司 一种嵌合肽修饰的sis膜、其制备方法及应用
CN113754795B (zh) * 2021-10-19 2023-03-10 澳门大学 磺酸化透明质酸类化合物、其制备方法及其应用
CN115040535B (zh) * 2022-08-15 2022-12-16 华南理工大学 硫酸化透明质酸在制备预防角膜纤维化、角膜瘢痕滴眼液中的应用
JP7725041B2 (ja) * 2023-07-26 2025-08-19 株式会社高研 コラーゲン結合型膜透過性ペプチド、並びに、該ペプチド及びコラーゲン若しくはコラーゲン誘導体を含む運搬体

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITPD940054A1 (it) * 1994-03-23 1995-09-23 Fidia Advanced Biopolymers Srl Polisaccaridi solfatati
HRP20190691T1 (hr) * 2008-03-27 2019-07-12 Purdue Research Foundation Sintetički peptidoglikani koji vezuju kolagen, priprema, i postupci upotrebe
US20120100106A1 (en) 2009-05-04 2012-04-26 Purdue Research Foundation Collagen-binding synthetic peptidoglycans for wound healing
US9173919B2 (en) 2011-02-16 2015-11-03 Purdue Research Foundation Collagen-targeted nanoparticles
EP3208278B1 (en) 2011-05-24 2018-10-31 Symic IP, LLC Hyaluronic acid-binding synthetic peptidoglycans, preparation, and methods of use
WO2014144969A1 (en) * 2013-03-15 2014-09-18 Purdue Research Foundation Extracellular matrix-binding synthetic peptidoglycans
WO2015164822A1 (en) 2014-04-25 2015-10-29 Purdue Research Foundation Collagen binding synthetic peptidoglycans for treatment of endothelial dysfunction
WO2015175565A2 (en) 2014-05-12 2015-11-19 Purdue Research Foundation Selectin and icam/vcam peptide ligand conjugates
WO2016061145A1 (en) 2014-10-13 2016-04-21 Symic Biomedical, Inc. Synthetic proteoglycans for preventing tissue adhesion
WO2016061147A1 (en) 2014-10-13 2016-04-21 John Eric Paderi Luminal vessel coating for arteriovenous fistula
WO2016065083A1 (en) 2014-10-21 2016-04-28 Symic Biomedical, Inc. Peptidoglycans comprising collagen-binding peptides for treating gastroesophageal injury
CN107530371B (zh) * 2015-01-09 2021-10-26 新加坡科技研究局 硫酸乙酰肝素的pdgf-b/pdgf-bb结合变体
WO2016161333A2 (en) 2015-04-01 2016-10-06 Purdue Research Foundation Compositions comprising bioconjugates
BR112017021970A2 (pt) * 2015-04-17 2018-07-10 Symic Ip Llc bioconjugados e usos dos mesmos
TW201718028A (zh) 2015-10-13 2017-06-01 賽米克Ｉｐ有限責任公司 Ve-鈣黏蛋白結合性生物結合物
WO2019010485A1 (en) 2017-07-07 2019-01-10 Symic Ip, Llc TREATMENT OF FIBROSIS
AU2018298224B2 (en) 2017-07-07 2024-08-15 Symic Ip, Llc Synthetic bioconjugates

Also Published As

Publication number Publication date
JP2020526493A (ja) 2020-08-31
US11896642B2 (en) 2024-02-13
CN111050778B (zh) 2024-09-10
AU2018298226A1 (en) 2020-01-23
US20210290726A1 (en) 2021-09-23
EP3648775A4 (en) 2021-04-21
AU2018298226B2 (en) 2024-06-06
WO2019010490A1 (en) 2019-01-10
JP2023065600A (ja) 2023-05-12
CN111050778A (zh) 2020-04-21
EP3648775A1 (en) 2020-05-13

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