KR20200018438A - 향상된 용해도의 약물-함유 제형 - Google Patents

향상된 용해도의 약물-함유 제형 Download PDF

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Publication number
KR20200018438A
KR20200018438A KR1020197036432A KR20197036432A KR20200018438A KR 20200018438 A KR20200018438 A KR 20200018438A KR 1020197036432 A KR1020197036432 A KR 1020197036432A KR 20197036432 A KR20197036432 A KR 20197036432A KR 20200018438 A KR20200018438 A KR 20200018438A
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KR
South Korea
Prior art keywords
acid
drug
acids
composition
combination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020197036432A
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English (en)
Korean (ko)
Inventor
마이클 레어드 허리
드라젠 오스토빅
피터 노이머
Original Assignee
스테디메드 리미티드
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Application filed by 스테디메드 리미티드 filed Critical 스테디메드 리미티드
Publication of KR20200018438A publication Critical patent/KR20200018438A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020197036432A 2017-05-11 2018-05-10 향상된 용해도의 약물-함유 제형 Ceased KR20200018438A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762504546P 2017-05-11 2017-05-11
US62/504,546 2017-05-11
PCT/IL2018/050511 WO2018207188A1 (en) 2017-05-11 2018-05-10 Enhanced solubility drug-containing formulations

Publications (1)

Publication Number Publication Date
KR20200018438A true KR20200018438A (ko) 2020-02-19

Family

ID=62599659

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020197036432A Ceased KR20200018438A (ko) 2017-05-11 2018-05-10 향상된 용해도의 약물-함유 제형

Country Status (9)

Country Link
US (1) US11672863B2 (https=)
EP (1) EP3621591A1 (https=)
JP (1) JP2020519593A (https=)
KR (1) KR20200018438A (https=)
CN (1) CN110869000A (https=)
AU (1) AU2018265624A1 (https=)
CA (1) CA3063322A1 (https=)
IL (1) IL271673A (https=)
WO (1) WO2018207188A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3621591A1 (en) 2017-05-11 2020-03-18 Steadymed Ltd. Enhanced solubility drug-containing formulations
AU2020323594B2 (en) * 2019-08-01 2022-02-03 Incarda Therapeutics, Inc. Antiarrhythmic formulation

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3910260A (en) 1972-03-01 1975-10-07 Survival Technology Method and apparatus of treating heart attack patients prior to the establishment of qualified direct contact personal care
US4004577A (en) 1972-12-04 1977-01-25 Survival Technology, Inc. Method of treating heart attack patients prior to the establishment of qualified direct contact personal care
US3941130A (en) 1975-03-18 1976-03-02 Tibbs Robert C Sequential trigger release for injection device
US4261358A (en) 1979-10-01 1981-04-14 Walter Vargas Automatic syringe plunger
US4795433A (en) 1985-05-20 1989-01-03 Survival Technology, Inc. Automatic injector for emergency treatment
US4689042A (en) 1985-05-20 1987-08-25 Survival Technology, Inc. Automatic medicament ingredient mixing and injecting apparatus
US4902692A (en) * 1988-03-18 1990-02-20 Iolab Corporation Method and composition for ophthalmic anesthesia using rodocaine
US5085642A (en) 1989-07-17 1992-02-04 Survival Technology, Inc. Conveniently carried frequent use autoinjector
US5102393A (en) 1989-07-17 1992-04-07 Survival Technology, Inc. Autoinjector converted from intramuscular to subcutaneous mode of injection
US5092843A (en) 1990-04-12 1992-03-03 Survival Technology, Inc. Dispersion multichamber auto-injector
US5267963A (en) 1992-08-21 1993-12-07 Nicholas Bachynsky Medication injection device
US5922340A (en) 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
DK0659073T3 (da) * 1992-09-10 2002-03-11 Childrens Medical Center Bionedbrydelige polymermatrixer med vedvarerende afgivelse af lokalanæstetika
US5705190A (en) * 1995-12-19 1998-01-06 Abbott Laboratories Controlled release formulation for poorly soluble basic drugs
US5747060A (en) * 1996-03-26 1998-05-05 Euro-Celtique, S.A. Prolonged local anesthesia with colchicine
CA2304096C (en) * 1997-09-18 2003-09-09 Pacira Pharmaceuticals, Inc. Sustained-release liposomal anesthetic compositions
US6149626A (en) 1997-10-03 2000-11-21 Bachynsky; Nicholas Automatic injecting syringe apparatus
SE9803662D0 (sv) 1998-10-26 1998-10-26 Pharmacia & Upjohn Ab Autoinjector
JP4775807B2 (ja) * 2004-12-02 2011-09-21 株式会社 メドレックス 局所麻酔薬物含有ゼリー剤
US20060270708A1 (en) * 2005-05-25 2006-11-30 Navinta Llc Novel process for preparation of isotonic aqueous injection of ropivacaine
MX2008016335A (es) 2006-06-30 2009-01-21 Abbott Biotech Ltd Dispositivo automatico de inyeccion.
CN101744760A (zh) * 2008-12-18 2010-06-23 梁颖 用于难溶性或易分解性药物的缓释体
CN102106806B (zh) * 2009-12-29 2013-04-17 上海中西制药有限公司 一种固体制剂的制备方法及所得固体制剂
CA2910865C (en) * 2014-07-15 2016-11-29 Isa Odidi Compositions and methods for reducing overdose
EP3375456B1 (en) * 2015-11-12 2023-05-03 Terumo Kabushiki Kaisha Sustained-release topically administered agent
EP3621591A1 (en) 2017-05-11 2020-03-18 Steadymed Ltd. Enhanced solubility drug-containing formulations

Also Published As

Publication number Publication date
US11672863B2 (en) 2023-06-13
JP2020519593A (ja) 2020-07-02
CN110869000A (zh) 2020-03-06
US20200054754A1 (en) 2020-02-20
WO2018207188A1 (en) 2018-11-15
IL271673A (en) 2020-02-27
EP3621591A1 (en) 2020-03-18
CA3063322A1 (en) 2018-11-15
AU2018265624A1 (en) 2019-12-05

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