KR20190104409A - Lag-3에 대하여 결합 친화성을 갖는 리포칼린 뮤테인 - Google Patents

Lag-3에 대하여 결합 친화성을 갖는 리포칼린 뮤테인 Download PDF

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KR20190104409A
KR20190104409A KR1020197023946A KR20197023946A KR20190104409A KR 20190104409 A KR20190104409 A KR 20190104409A KR 1020197023946 A KR1020197023946 A KR 1020197023946A KR 20197023946 A KR20197023946 A KR 20197023946A KR 20190104409 A KR20190104409 A KR 20190104409A
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크리스틴 로테
섀인 올윌
안드레아 앨러스도르페
티모 아이크너
라치다 시함 벨 아이바
마리나 파블리도
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피어이스 파마슈티컬즈 게엠베하
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
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    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2318/00Antibody mimetics or scaffolds
    • C07K2318/20Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3

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  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020197023946A 2017-01-18 2018-01-18 Lag-3에 대하여 결합 친화성을 갖는 리포칼린 뮤테인 Ceased KR20190104409A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17151945.7 2017-01-18
EP17151945 2017-01-18
PCT/EP2018/051139 WO2018134274A1 (en) 2017-01-18 2018-01-18 Lipocalin muteins with binding affinity for lag-3

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KR20190104409A true KR20190104409A (ko) 2019-09-09

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KR1020197023946A Ceased KR20190104409A (ko) 2017-01-18 2018-01-18 Lag-3에 대하여 결합 친화성을 갖는 리포칼린 뮤테인

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US (2) US11168119B2 (cg-RX-API-DMAC7.html)
EP (1) EP3571219A1 (cg-RX-API-DMAC7.html)
JP (1) JP7225116B2 (cg-RX-API-DMAC7.html)
KR (1) KR20190104409A (cg-RX-API-DMAC7.html)
CN (1) CN110402252A (cg-RX-API-DMAC7.html)
AU (1) AU2018209178B2 (cg-RX-API-DMAC7.html)
BR (1) BR112019014691A2 (cg-RX-API-DMAC7.html)
CA (1) CA3050194A1 (cg-RX-API-DMAC7.html)
MX (1) MX2019008434A (cg-RX-API-DMAC7.html)
RU (1) RU2019122482A (cg-RX-API-DMAC7.html)
SG (1) SG11201906509WA (cg-RX-API-DMAC7.html)
WO (1) WO2018134274A1 (cg-RX-API-DMAC7.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108348573A (zh) 2015-07-15 2018-07-31 皮里斯制药有限公司 Lag-3特异性的新型蛋白
EP3571219A1 (en) 2017-01-18 2019-11-27 Pieris Pharmaceuticals GmbH Lipocalin muteins with binding affinity for lag-3
WO2020201038A1 (en) 2019-03-29 2020-10-08 Pieris Pharmaceuticals Gmbh Inhaled administration of lipocalin muteins
CA3177098A1 (en) 2020-06-05 2021-12-09 Pieris Pharmaceuticals Gmbh Multimeric immunomodulator targeting 4-1bb
KR20230165917A (ko) * 2021-04-08 2023-12-05 피어이스 파마슈티컬즈 게엠베하 결합 조직 성장 인자(ctgf)에 특이적인 신규 리포칼린 뮤테인
CN113480667B (zh) * 2021-08-17 2023-03-28 长春萤火虫生物科技有限公司 一种人粒细胞集落刺激因子突变体重组融合蛋白及其制备方法和应用
CN113754743B (zh) * 2021-10-12 2024-02-02 成都齐碳科技有限公司 孔蛋白单体的突变体、蛋白孔及其应用
WO2023118497A1 (en) 2021-12-22 2023-06-29 Pieris Pharmaceuticals Gmbh Novel il-18 variants

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FR2649991B2 (fr) 1988-08-05 1994-03-04 Rhone Poulenc Sante Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces
US5728553A (en) 1992-09-23 1998-03-17 Delta Biotechnology Limited High purity albumin and method of producing
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DE19742706B4 (de) 1997-09-26 2013-07-25 Pieris Proteolab Ag Lipocalinmuteine
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WO2007107563A2 (en) 2006-03-20 2007-09-27 Technische Universität München Muteins of tear lipocalin with affinity for the t-cell coreceptor cd4
EP2245054B1 (en) 2008-01-30 2018-11-28 Pieris Pharmaceuticals GmbH Muteins of tear lipocalin having affinity to human c-met receptor tyrosine kinase and methods for obtaining the same
WO2013087660A1 (en) 2011-12-13 2013-06-20 Pieris Ag Methods for preventing or treating certain disorders by inhibiting binding of il-4 and/or il-13 to their respective receptors
WO2013174783A1 (en) 2012-05-23 2013-11-28 Pieris Ag Lipocalin muteins with binding-affinity for glypican-3 (gpc-3) and use of lipocalin muteins for target-specific delivery to cells expressing gpc-3
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RU2021119777A (ru) * 2015-05-18 2021-08-16 ПИЕРИС ФАРМАСЬЮТИКАЛС ГмбХ Слитый полипептид, способный связывать cd137 и gpc3, молекула нуклеиновой кислоты, содержащая нуклеотидную последовательность, кодирующую такой слитый полипептид, способ его получения и пути применения
CN108348573A (zh) 2015-07-15 2018-07-31 皮里斯制药有限公司 Lag-3特异性的新型蛋白
EP3571219A1 (en) 2017-01-18 2019-11-27 Pieris Pharmaceuticals GmbH Lipocalin muteins with binding affinity for lag-3

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JP7225116B2 (ja) 2023-02-20
CN110402252A (zh) 2019-11-01
BR112019014691A2 (pt) 2020-04-07
WO2018134274A1 (en) 2018-07-26
CA3050194A1 (en) 2018-07-26
SG11201906509WA (en) 2019-08-27
AU2018209178A1 (en) 2019-08-01
RU2019122482A3 (cg-RX-API-DMAC7.html) 2021-05-26
US20220098253A1 (en) 2022-03-31
US20190345207A1 (en) 2019-11-14
US11773147B2 (en) 2023-10-03
EP3571219A1 (en) 2019-11-27
MX2019008434A (es) 2019-11-11
RU2019122482A (ru) 2021-02-19
AU2018209178B2 (en) 2021-07-29
JP2020505948A (ja) 2020-02-27
US11168119B2 (en) 2021-11-09

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