KR20190079035A - Composition for promoting hair growth comprising extract of Houttuynia cordata as effective component - Google Patents

Abstract

The present invention relates to a composition for promoting hair growth comprising Houttuynia cordata extract as an active ingredient. The composition comprising the Houttuynia cordata extract of the present invention is excellent in inhibiting and preventing hair loss or promoting hair growth, and thus can be used as a functional product for preventing hair loss and promoting hair growth.

Description

[0001] The present invention relates to a composition for promoting hair growth comprising an extract of Houttuynia cordata as an active ingredient,

The present invention relates to a composition for promoting hair growth comprising an extract of Rhododendron japonica as an active ingredient.

The human body has an average of about 100,000 hairs, and they repeatedly produce and disappear through periodic changes of anagen, catagen, telogen, and exogen. Hair loss refers to the fact that the period corresponding to the growth period of the hair cycle is shortened due to various causes, and the ratio of the retrogressive hair to the resting hair increases. The cause of hair loss varies depending on the individual, but genetic factors, Lack of nutrients supplied to the hair follicles, lack of oxygen supply due to excessive amount of scalp, inflammation due to lipid or foreign matter or scalp disease, clogging of the pores, and stress. In addition, if the blood circulation is good, nutrients and oxygen are supplied smoothly to the hair follicles and the hair can grow healthily. However, hair loss can be promoted if the blood circulation is not smooth due to the high fat diet or smoking.

Male genitals are involved in hair loss caused by genetic factors. Testosterone, one of the male hormones, is converted to the active dihydrotestosterone by an enzyme called 5α-reductase. After puberty, excess secreted dihydrotestosterone acts as a major cause of excess sebum production in sebocytes, leading to acne and male hair loss. In particular, hair follicle cells are more likely to cause hair loss because dihydrotestosterone binds more to the hormone receptor than testosterone.

In addition, at the base of the scalp, cell division occurs constantly, and it is gradually crooked to the surface of the skin and becomes keratinized to form a stratum corneum on the outermost side of the scalp. This dandruff mixes with the sebum coming out of the sebaceous glands and becomes bored, which blocks the pores and causes nutritional disorders and atrophy, resulting in hair loss. Boring itself is a secondary phenomenon due to the action of male hormones, and boring itself is not the cause of hair loss. In other words, male hormones thin hair, but the sebaceous glands increase the secretion of sebum. When the sebaceous gland becomes enlarged and functioning, the dandruff on the surface of the hair increases and the secretion of 5-alpha-reductase increases, affecting hair growth and growth.

Hair loss can be as diverse as the variety of causes. To prevent hair loss and promote hair growth, blood vessels are expanded to supply nutrients to the hair follicles, and external preparations, health supplements, and medicines that directly supply the hair root with components similar to those of the hair are being marketed. However, there have been reported cases of adverse drug reactions (angina, skin diseases, itching, etc.) and side effects due to the use of chemicals, and there is a problem that expensive money is invested for treating hair loss, .

Houttuynia cordata is an outbreak of anomalies, a plant of the Saururaceae, which lives in southeastern Asia and especially in Japan and Korea. It is said that there are ten kinds of phytophthora, and the stem is like leaf of sweet potato. It can be used for medicinal and edible purposes. It is classified as a plant or a plant which can only use the minimum amount as a supplementary ingredient in food raw material classification. It is widely known to have pharmacological effects such as strength, diuretic, antimicrobial, In the private sector, they are used as cosmetics and health functional foods to help detoxification and beauty.

On the other hand, Korean Patent No. 1661245 discloses a herbal cosmetic composition for protecting skin and scalp, preventing hair loss, and a method for producing the same, which comprises a composition comprising a compound of formula (I), a compound of formula (I), a compound of formula Korean Patent Laid-Open Publication No. 2016-0109332 discloses a composition having an effect of preventing hair loss and promoting hair growth, which comprises a combination extract comprising a heat-treated ginseng, a zelkova, a lobule, and a green tea leaf as an active ingredient. There is no description about a composition for promoting hair growth that contains an extract as an active ingredient.

The present invention has been made in view of the above-mentioned needs. The present inventors have completed the present invention by confirming that Hwasungcho extract has no toxicity to dermal papilla cells, differentiates lipid precursor cells, and has excellent antioxidative activity.

In order to solve the above problems, the present invention provides a cosmetic composition for accelerating hair growth, a health functional food composition, and a pharmaceutical composition, which comprise an extract of Rhododendron japonica as an active ingredient.

Since the extract of Hwasung extract according to the present invention has little cytotoxicity and is excellent in antioxidative effect for protecting the body from various oxidative stresses, it can be used as a novel natural material for cosmetics, health functional food or pharmaceutical composition for preventing hair loss or promoting hair growth Can be usefully used.

1 shows the result of TLC analysis of a water extract of a water-soluble herbicide (A), a water extract of a herb of a plant and five fractions (B, hexane, hexane, CHCl ₃ ; chloroform, EA; ethyl acetate, n-butanol, butanol, DW; distilled water) . R _f 0.50; Chlorogenic acid, R _f 0.54; Hyperoside, R _f 0.79; Quercitrin, and R _f 0.88; Afzelin.
2 shows the HPLC results of standard reagents (A to C) and Hwasungcho ethanol extracts (D to F). A and D are 280 nm; B and E are 320 nm; And C and F were confirmed at 280 nm. One; Gallic acid, 2; Cumaric acid, 3; Salicylic acid, 4; Trans-cinnamic acid, 5; Quercitrin, 6; Quercetin, 7; Chlorogenic acid, 8; Isoquercitrin, 9; Hyde to the side.
FIG. 3 shows the results of analysis of cytotoxicity of the extract of Hwasungcho extract in fibroblasts.
Fig. 4 shows the result of analysis of cytotoxicity of Hwasungcho ethanol extract in human dermal papilla cells.
FIG. 5 shows the results of cytotoxicity analysis of the ethanol extract of Hwasungcho extract from lipid precursor cells.
FIG. 6 shows the results of differentiation (A) and oil-red O staining (B) from adipocyte precursor cells (3T3-L1) DM II; Differentiation inducing substance.
7 is a graph showing electron donating ability (A), ABTS radical scavenging ability (B), and superoxide anion scavenging ability (C) measured for analyzing the antioxidative effect of ethanol extract of Hwasungcho. Vitamin C; Control group.

In order to accomplish the object of the present invention, the present invention provides a cosmetic composition for accelerating hair growth comprising an extract of Aspergillus as an active ingredient.

In the cosmetic composition for promoting hair growth in accordance with an embodiment of the present invention, the extract may be water, a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof, as an extraction solvent, preferably 1 to 4 carbon atoms Of lower alcohol, and more preferably ethanol extract, but is not limited thereto.

Further, in the cosmetic composition for promoting hair growth according to an embodiment of the present invention,

1) pulverizing the seedlings to a size of 150 to 350 mesh;

2) adding 30 to 50 parts by weight of ethanol to 1 part by weight of the seedling powder of step 1), and extracting the mixture for 24 to 60 hours; And

3) filtering the Horsetail extract of step 2), and more specifically,

1) pulverizing the seeds so as to have a mesh of 200 to 300 mesh;

2) adding 40 parts by weight of ethanol to 1 part by weight of crushed asps powder in step 1), and extracting the mixture for 48 hours; And

3) filtering the Horsetail extract of step 2), but is not limited thereto.

In the cosmetic composition for promoting hair growth according to an embodiment of the present invention, the extract obtained in the step 3) may be an extract obtained by repeating the step 2) twice more preferably the step 2 ), And an extract obtained by adding ethanol to the remaining residue after filtration and extracting and filtering the extract twice. The extract is not limited thereto.

As used herein, the term " hair growth promoting "refers to promoting the production and growth of hair, ultimately increasing the specific gravity of growing hair in total hair. Therefore, the term has the same meaning as "hair loss improvement "," hair loss prevention ", and "hair loss treatment" since it means suppressing hair loss caused by a decrease in specific gravity of growing hair.

In the cosmetic composition for promoting hair growth according to an embodiment of the present invention, the composition may be a hair conditioner, a hair tonic, a hair cream, a hair lotion, a hair oil, a hair spray, a shampoo or a rinse, , But is not limited thereto.

The cosmetic composition includes components commonly used in cosmetic compositions and includes, for example, customary adjuvants such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavors, and carriers.

The carrier may be selected from the group consisting of purified water, monohydric alcohols (ethanol or propyl alcohol), polyhydric alcohols (glycerol, 1,3-butylene glycol or propylene glycol), higher fatty acids (palmitic acid or linolenic acid) But are not limited to, oil, jojoba oil, olive oil, squalane, sunflower oil, macadamia peanut oil, avocado oil, soybean water-added lecithin or fatty acid glyceride). If necessary, a surfactant, a bactericide, an antioxidant, an ultraviolet absorber, an anti-inflammatory agent and a refreshing agent may be added.

The surfactant is selected from the group consisting of polyoxyethylene, hardened castor oil, polyoxyethylene, oleyl ether, polyoxyethylene monooleate, polyoxyethylene, glyceryl monostearate, monostearic acid sorbitan, monooleic acid polyoxyethylene, sorbitan, Polyglycerol fatty acid ester, sucrose fatty acid ester, monolauric acid hexaglycerin, polyoxyethylene reduced lanolin, POE, glyceryl pyroglutamic acid, isostearic acid, diester, N-acetylglutamine and isostearyl ester.

The fungicide may optionally be selected from the group consisting of: hynochitol, trichloro acid, chlorohexidine gluconate, phenoxyethanol, resorcin, isopropylmethylphenol, azulene, salicylic acid and zinc pyrithione have.

As the antioxidant, any of butylhydroxyanisole, gallic acid, propyl gallate, and erythorbic acid may be used.

The ultraviolet absorber may be at least one selected from the group consisting of benzophenones such as dihydroxybenzophenone and the like, melanin, ethyl paraaminobenzoate, 2-ethylhexyl paradimethylbenzoate, synonym, 2-ethylhexyl phamethoxycinnamate, 2- Hydroxy-5-methylphenyl) benzotriazole, urocanic acid, and metal oxide fine particles.

As the anti-inflammatory agent, dipotassium glycyrrhizinate or allantoin can be used, and as a refreshing agent, pepper tincture or 1-menthol can be used.

Further, the cosmetic composition according to the present invention can be used in combination with a hair or hair restorer conventionally used as long as the action (hair growth) of the present invention is not impaired.

The present invention also provides a health functional food composition for accelerating hair growth comprising an extract of Rhododendron japonica as an active ingredient.

The health functional food composition may be prepared in any form of powder, granule, ring, tablet, capsule, candy, syrup, foamable beverage and beverage, but is not limited thereto. The health functional food composition is not particularly limited as long as it can be ingested to promote hair growth.

When the Horticultural Extract of the present invention is used as a food additive, the Horticultural Extract may be added as it is or may be used together with other food or food ingredients, and may be appropriately used according to a conventional method. The active ingredient may be suitably used depending on its intended use (prevention or improvement). Generally, the fermented product of the extract of Hwasung extract of the present invention is added in an amount of not more than 15 parts by weight, preferably not more than 10 parts by weight based on the raw material. However, in the case of long-term intake for the purpose of controlling health, it can be used in an amount that does not cause any safety problems.

There is no particular limitation on the kind of the food. Examples of the foods to which the health functional food composition can be added include dairy products including meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen and other noodles, gums, ice cream, soups, Drinks, alcoholic beverages, and vitamin complexes, all of which include health foods in a conventional sense. The beverage includes carbonated beverages, functional ionic beverages, juice (e.g., apple, pear, grape, aloe, citrus, peach, carrot, tomato juice, etc.), sikhye, and the like.

The functional food of the present invention includes components that are ordinarily added in food production, and includes, for example, proteins, carbohydrates, fats, nutrients, and seasonings. For example, in the case of a drink, a natural carbohydrate or a flavoring agent may be included as an additional ingredient in addition to the active ingredient. The natural carbohydrate may be selected from the group consisting of monosaccharides (e.g., glucose, fructose, etc.), disaccharides (e.g., maltose, sucrose etc.), oligosaccharides, polysaccharides (e.g., dextrin, cyclodextrin, , Xylitol, sorbitol, erythritol, etc.). The flavoring agent may be a natural flavoring agent (e.g., tau Martin, stevia extract, etc.) and a synthetic flavoring agent (e.g., saccharin, aspartame, etc.). In addition to the above-mentioned health functional food composition, it is possible to use various nutrients, vitamins, electrolytes, flavors, colorants, pectic acid and salts thereof, alginic acid and its salts, organic acids, protective colloid thickening agents, pH adjusting agents, stabilizers, preservatives, glycerin, A carbonating agent used in beverages, and the like.

The present invention also provides a pharmaceutical composition for accelerating hair growth comprising an extract of Aspergillus as an active ingredient.

The composition comprising the perennial herb extract of the present invention may further comprise an appropriate carrier, excipient or diluent conventionally used in the production of a pharmaceutical composition.

The pharmaceutical dosage forms of the pharmaceutical compositions of the present invention may be used alone or in combination with other pharmaceutically active compounds as well as in suitable combinations.

The pharmaceutical composition according to the present invention may be formulated in the form of powders, granules, tablets, capsules, oral preparations such as suspensions, emulsions, syrups and aerosols, external preparations, suppositories and injections according to conventional methods .

Examples of carriers, excipients and diluents that can be included in the pharmaceutical composition include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose , Methylcellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil, and the like.

In the case of formulation, a diluent or excipient such as a filler, an extender, a binder, a wetting agent, a disintegrant, or a surfactant is usually used. Solid formulations for oral administration include tablets, pills, powders, granules, capsules and the like, which may contain at least one excipient such as starch, calcium carbonate, sucrose or lactose, gelatin, . In addition to simple excipients, lubricants such as magnesium stearate and talc are also used. Examples of liquid formulations for oral use include suspensions, solutions, emulsions and syrups. In addition to water and liquid paraffin, which are commonly used simple diluents, various excipients such as wetting agents, sweeteners, fragrances, preservatives and the like have. Formulations for parenteral administration include sterilized aqueous solutions, non-aqueous solutions, suspensions, emulsions, freeze-dried preparations, and suppositories. Examples of the suspending agent include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like. Examples of the suppository base include withexol, macrogol, tween 61, cacao butter, laurin, glycerogelatin and the like.

The preferred dosage of the pharmaceutical composition of the present invention varies depending on the condition and the weight of the patient, the degree of disease, the type of drug, the administration route and the period of time, but can be appropriately selected by those skilled in the art. The pharmaceutical composition of the present invention can be administered to mammals such as rats, mice, livestock, humans, and the like in various routes. All modes of administration may be expected, for example, by oral, rectal or intravenous, intramuscular, subcutaneous, intra-uterine or intracerebroventricular injections.

Hereinafter, the present invention will be described in detail with reference to examples. However, the following examples are illustrative of the present invention, and the present invention is not limited to the following examples.

Production Example 1. Preparation of Houttuynia cordata extract

Hwasungcho was purchased from Jiri Mountain D & H Co., and crushed by using a blender so as to have 200-300 mesh. 50 g of pulverized cord blood powder was added to 2,000 mL of 70% (v / v) ethanol and extracted at room temperature for 48 hours. After filtration, 500 mL of 70% (v / v) ethanol was added to the filtrate, and the mixture was incubated at room temperature for 24 hours. The mixture was filtered through a filter and stored at 4 ° C. To the supernatant, 500 mL of 70% (v / v) ethanol was added and mixed. After 24 hours of room temperature extraction, the extract was filtered and mixed with the extract Concentrated under reduced pressure at 40 ° C and 55 rpm, lyophilized and stored at 4 ° C.

Example 1. Thin-layer chromatography (TLC) analysis

Thin layer chromatography was performed using ethanol extract, hexane extract, chloroform extract, ethyl acetate extract and butanol extract of Rhododendron japonica according to the standards of standardized herbal medicine. The developing solvent for the thin layer chromatography was ethyl acetate: Distilled water: Formic acid: Acetic acid was developed using mixed solution of 100: 15: 7: 7 ratio.

As a result of UV / Vis short wavelength (254 nm), long wave length (365 nm) and 10% sulfuric acid (H ₂ SO ₄ ) coloring, the four main components of Hwasungcho, chlorogenic acid, hyperoside, quercitrin and afzelin. Especially, it was confirmed that the quercitrin component was clearly detected (FIG. 1A). The above-mentioned components are the values of R _{f for} each component described in the reference document (Analytical Sci. 2015, 31 (6), 535-41, 2014, 0.5, 0.54, 0.79, 0.88).

In addition, five fractions were obtained from the Horseshoe ethanol extract prepared above, namely, n-hexane fraction, chloroform (CHCl ₃ ) fraction, ethyl acetate fraction, butanol fraction and distilled water fraction Thin layer chromatography was carried out using the above extracts and five fractions.

As a result, it was confirmed that the ethyl acetate fraction and the ethyl acetate fraction of the five fractions contained the most major components than the other fractions (FIG. 1B).

Example 2. HPLC (high pressure liquid chromatography) analysis

Quantitative evaluation was carried out by HPLC analysis of the standard reagent and Hwasungcho ethanol extract. HPLC analysis conditions are shown in Table 1 below. The phenolic acid standard used in the quantitative evaluation was selected from chlorogenic acid, cinnamic acid, coumaric acid, gallic acid, and salicylic acid. And flavonoid standards were selected for hyperoside, quercetin, isoquercitrin, quercitrin, and the like.

As a result, the retention time of the standard reagent was about 28.216 min (1); Cumaric acid (2) at about 31.823 min; Salicylic acid (3) at about 37.525 min; Trans-cinnamic acid (4) at about 40.006 min; Quercitrin (5) at about 33.052 min; Quercetin (6) at about 39,300 min; Chlorogenic acid (7) at about 26.078 min; Isoquercitrin (8) at about 30.762 min; At about 30.974 min, a peak corresponding to the hyper-side 9 was observed (Figs. 2A-C).

In addition, the extracts of Hwasungcho extracts showed quercitrin (5) at a retention time of about 33.052 min; Quercetin (6) at about 39.321 min; Chlorogenic acid (7) at about 26.119 min; Isoquercitrin (8) at about 30.802 min; At about 31.037 min, a peak corresponding to the hyperoside 9 was observed (Figures 2D-F). The results of the quantitative evaluation of each component according to the HPLC results of the fractions of the herbal extracts and the herbal extracts are shown in Table 2 below.

HPLC analysis conditions of Horseshoe chinensis extract division Analysis condition HPLC Agilent 1200 series Mobile phase 0.1% Formic acid / acetonitrile mixture Detector A multi-wavelength detector (MWD) Column Aegispak-L C18 (4.6 x 200 mm ID, 3 mu m) Temperature 35 dg. Flow rate 0.45 mL / min Injection volumne 15 μl

The content of major components Extracted conditions Acquired results (μg / mg) of analytes in Houttuynia cordata One 2 3 4 5 6 7 8 9 70% Ethanol 0.32 0.08 N.C. 0.19 20.14 0.25 15.2 2.81 0.85 n-Hexane 0.08 N.C. N.C. N.C. 0.02 N.C. 0.46 N.C. N.C. Chloroform 0.04 0.06 N.C. 1.39 9.59 0.44 0.81 1.12 0.3 Ethyl acetate 0.55 1.63 N.C. 8.61 5.27 0.39 0.4 0.23 0.02 n-Butanol 5.71 2.19 N.C. 0.57 27.67 4.76 49.52 21.61 12.46 Water 0.44 0.13 N.C. N.C. 2.03 0.46 34.06 1.19 0.51

Example 3: Cytotoxicity analysis of Hwasungcho extract

3-1. Fibroblast toxicity analysis

Fibroblasts produce collagen and elastin, and constitute the dermis of the skin tissue. Although collagen acts to make scalp healthy and prevent hair loss and to make hair healthy, the amount of structural proteins such as collagen, elastin or fibroblast decreases as aging progresses, resulting in tissue loosening and hair loss.

Cell viability was determined at the concentrations of 10, 50, 100, and 500 ㎍ / mL of Hwasungcho extracts by 100%, 100%, and 500 ㎍ / mL, respectively. 107.3%, 109.6%, and 128.2%, respectively, and it was confirmed that there was no cytotoxicity (FIG. 3). This suggests that ethanol extract of Hwasungcho may affect the proliferation of fibroblasts and thus may be useful as a useful material for the development of hair growth and hair loss products.

3-2. Toothpick cytotoxicity analysis

Human follicle dermal papilla cells (HFDPCs) are involved in hair growth and hair loss by allowing hair growth signals to be transferred to hair matrix cells to form hair.

Cell viability of human dermal papilla cells at 10, 50, 100, and 500 ㎍ / mL concentrations of 10, 50, 100, and 500 ㎍ / Were found to be 101.1%, 99.6%, 98.4%, and 96.6%, respectively, indicating no cytotoxicity (Fig. 4).

3-3. Toxicity analysis of lipogenic precursor cells (3T3-L1)

The cytotoxicity was examined 24 hours after treatment of liposome progenitor cells (3T3-L1) with 10, 50, 100 and 500 ㎍ / mL, The cell viability was 97.3%, 98.4% and 95.6%, respectively. However, the cell survival rate was found to be 74.5% at the concentration of 500 ㎍ / mL, and it was confirmed that the progesterone ethanol extract was not toxic up to 100 ㎍ / (Fig. 5).

Example 4. Analysis of differentiation of lipid precursor cells

The lipid precursor cells were treated with 10, 50, 100, and 500 ㎍ / mL, respectively, and the differentiation rate from adipose precursor cells to adipocytes was measured.

As a result, the differentiation rate of adipocyte progenitor cells increased as the concentration of the ethanol extract of the perennial herb was increased. Especially, the group treated with the ethanol extract of the perennial herb of 500 ㎍ / mL showed a differentiation inducer (DMII; 1 μM Dexamethasone, 0.5 mM IBMX IsoButhylMethylXanthine), 10 μg / mL Insulin) compared with the control, which was about 1.3 times higher than that of the control (FIG. 6A).

In addition, the oil-red O staining was performed to confirm the morphological differentiation into adipocytes. As a result, it was observed that the 500 ㎍ / mL concentration of the ethanol extract of Hwasungcho significantly increased the stained portion compared with the control, And the lipid precursor cells were differentiated into adipocytes (FIG. 6B).

It was confirmed that the ethanol extract of Hwasungcho extract promoted the differentiation from preadipocyte to adipocyte, and the hypodermis composed of adipose tissue regulates body temperature, cushioning function, and provides nutrients to the hair .

Example 5 Analysis of Total Phenol Content of Ethanol Extract of Rhizosphere

The polyphenolic compound is one of the secondary metabolites widely distributed in the vegetable field. It is known as a physiologically active substance having antioxidative, anticancer and antimicrobial activities, and exhibits antioxidative activity in most plants.

The total polyphenols content in the lyophilized product of Hwasungcho extract was found to be 5.89%.

Example 6 Antioxidant Activity Analysis of Ethanol Extract of Hwasungcho

6-1. Analysis of electron donating ability (EDA) and ABTS scavenging activity

The electron donating ability and the ABTS radical scavenging activity of each of the extracts of Hwasungcho extracts (1, 5, 10, 50, 100 and 500 ㎍ / mL) were measured in terms of the concentration of lyophilized product. The electron donating ability (FIG. 7A) and the ABTS radical scavenging ability 7B). Especially, in the case of electron donating ability, it was confirmed that the concentration of ethanol extract of Hwasungcho extract showed a strong electron donating ability similar to that of the control treated with vitamin C at a concentration of 50 ㎍ / mL or more.

6-2. Superoxide anion radical scavenging activity (SOSA) analysis

As a result of measuring the inhibitory activity of superoxide anion radicals produced by xanthine oxidase by concentration (1, 5, 10, 50, 100 and 500 ㎍ / mL) of lyophilized ethanol extract, (Fig. 7C). In particular, the ethanol extract of Hwasungcho showed higher radical scavenging activity than the control of vitamin C at a concentration of 10 ㎍ / mL or higher.

Claims (4)

A cosmetic composition for accelerating hair growth comprising an extract of Aspergillus as an active ingredient. The cosmetic composition for skin whitening according to claim 1, wherein the extract is extracted using water, a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof. A health functional food composition for accelerating hair growth comprising an extract of Aspergillus as an active ingredient. A pharmaceutical composition for promoting hair growth comprising an extract of Aspergillus as an active ingredient.

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