KR20190077471A - 방향 선택적인 망막 신경절 세포에서의 유전자의 특이적 발현을 위한 프로모터, synp198 - Google Patents

방향 선택적인 망막 신경절 세포에서의 유전자의 특이적 발현을 위한 프로모터, synp198 Download PDF

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KR20190077471A
KR20190077471A KR1020197015426A KR20197015426A KR20190077471A KR 20190077471 A KR20190077471 A KR 20190077471A KR 1020197015426 A KR1020197015426 A KR 1020197015426A KR 20197015426 A KR20197015426 A KR 20197015426A KR 20190077471 A KR20190077471 A KR 20190077471A
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nucleic acid
cell
gene
sequence
acid sequence
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도미니크 하르틀
조세핀 위트너
아르나우트 크렙스
보톤트 로스카
디르크 쉬벨러
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프리드리히 미셔 인스티튜트 포 바이오메디칼 리서치
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KR1020197015426A 2016-11-02 2017-11-01 방향 선택적인 망막 신경절 세포에서의 유전자의 특이적 발현을 위한 프로모터, synp198 Ceased KR20190077471A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16196818 2016-11-02
EP16196818.5 2016-11-02
PCT/IB2017/056792 WO2018083607A1 (en) 2016-11-02 2017-11-01 Synp198, a promoter for the specific expression of genes in direction selective retinal ganglion cells

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KR20190077471A true KR20190077471A (ko) 2019-07-03

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US (1) US11525145B2 (https=)
EP (1) EP3534966B1 (https=)
JP (1) JP7023279B2 (https=)
KR (1) KR20190077471A (https=)
CN (1) CN110072557B (https=)
AU (1) AU2017354086C1 (https=)
BR (1) BR112019008488A2 (https=)
CA (1) CA3042197A1 (https=)
IL (1) IL266115A (https=)
RU (1) RU2766353C2 (https=)
WO (1) WO2018083607A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011516091A (ja) 2008-04-18 2011-05-26 ノバルティス・フォルシュングスシュティフトゥング・ツヴァイクニーダーラッスング・フリードリッヒ・ミーシェー・インスティトゥート・フォー・バイオメディカル・リサーチ 失明の治療のための新規な治療用ツールおよび方法
ES2747433T3 (es) 2015-04-30 2020-03-10 Friedrich Miescher Institute For Biomedical Res Promotor para la expresión específica de genes en células de Müller
WO2017046084A1 (en) 2015-09-15 2017-03-23 Friedrich Miescher Institute For Biomedical Research Novel therapeutical tools and methods for treating blindness by targeting photoreceptors
EP3362101B1 (en) 2015-10-14 2021-05-19 Friedrich Miescher Institute for Biomedical Research Promoter for the specific expression of genes in retinal endothelial cells
JP7075341B2 (ja) 2015-12-03 2022-05-25 フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ ＳｙｎＰ１６２、桿体光受容器における遺伝子の特異的発現のためのプロモーター
BR112018011059A2 (pt) 2015-12-03 2018-11-21 Friedrich Miescher Institute For Biomedical Research synp161, um promotor para a expressão específica de genes em fotoreceptores de haste
US10995344B2 (en) 2015-12-03 2021-05-04 Friedrich Miescher Institute For Biomedical Research SYNP159, a promoter for the specific expression of genes in rod photoreceptors
WO2017093934A1 (en) 2015-12-03 2017-06-08 Friedrich Miescher Institute For Biomedical Research Synp160, a promoter for the specific expression of genes in rod photoreceptors
CA3042197A1 (en) 2016-11-02 2018-05-11 Friedrich Miescher Institute For Biomedical Research Synp198, a promoter for the specific expression of genes in direction selective retinal ganglion cells
JP7112414B2 (ja) 2017-02-08 2022-08-03 フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ 網膜神経節細胞中の遺伝子の特異的発現のためのプロモーターｓｙｎｐ８８
CN111726985B (zh) 2017-11-15 2022-06-10 弗里德里克·米谢尔生物医学研究所 灵长类动物视网膜色素上皮细胞特异性启动子
JP2021503934A (ja) 2017-11-30 2021-02-15 フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ 網膜色素上皮中の遺伝子の特異的発現のためのプロモーターＳｙｎＰＩＩＩ
WO2020084541A1 (en) * 2018-10-25 2020-04-30 Friedrich Miescher Institute For Biomedical Research Synp151 (proc29), a promoter for the specific expression of genes in retinal ganglion cells
KR20230148207A (ko) * 2021-02-22 2023-10-24 더 리전츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코퍼레이트 안구 병태에 대한 바이러스 벡터-기반 유전자 요법

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2019588A4 (en) * 2006-05-04 2010-11-24 Univ Wayne State RESTORATION OF VISUAL RESPONSES BY IN VIVO ADMINISTRATION OF NUCLEIC ACIDS OF RHODOPSIN
EP1891976A1 (en) 2006-08-23 2008-02-27 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Research Use of light sensitive genes
JP2011516091A (ja) 2008-04-18 2011-05-26 ノバルティス・フォルシュングスシュティフトゥング・ツヴァイクニーダーラッスング・フリードリッヒ・ミーシェー・インスティトゥート・フォー・バイオメディカル・リサーチ 失明の治療のための新規な治療用ツールおよび方法
ES2563984T3 (es) * 2008-10-22 2016-03-17 Quark Pharmaceuticals, Inc. Métodos para el tratamiento de trastornos oculares
US20140287510A1 (en) * 2011-11-08 2014-09-25 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute Rod cell-specific promoter
EP2888368A1 (en) 2012-08-27 2015-07-01 Friedrich Miescher Institute for Biomedical Research Retinal off circuit-specific promoter
AU2014265799B2 (en) * 2013-05-16 2019-10-31 Applied Genetic Technologies Corporation Promoters, expression cassettes, vectors, kits, and methods for the treatment of achromatopsia and other diseases
EP3007730A1 (en) 2013-06-11 2016-04-20 Friedrich Miescher Institute for Biomedical Research Retinal on bipolar cells-specific artificial promoter
WO2015118507A1 (en) 2014-02-10 2015-08-13 Friedrich Miescher Institute For Biomedical Research Aii retinal amacrine cell-specific promoter
WO2015121793A1 (en) 2014-02-11 2015-08-20 Friedrich Miescher Institute For Biomedical Research Müller cell-specific promoter
ES2747433T3 (es) 2015-04-30 2020-03-10 Friedrich Miescher Institute For Biomedical Res Promotor para la expresión específica de genes en células de Müller
WO2017046084A1 (en) 2015-09-15 2017-03-23 Friedrich Miescher Institute For Biomedical Research Novel therapeutical tools and methods for treating blindness by targeting photoreceptors
EP3362101B1 (en) 2015-10-14 2021-05-19 Friedrich Miescher Institute for Biomedical Research Promoter for the specific expression of genes in retinal endothelial cells
WO2017093934A1 (en) 2015-12-03 2017-06-08 Friedrich Miescher Institute For Biomedical Research Synp160, a promoter for the specific expression of genes in rod photoreceptors
JP7075341B2 (ja) 2015-12-03 2022-05-25 フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ ＳｙｎＰ１６２、桿体光受容器における遺伝子の特異的発現のためのプロモーター
US10995344B2 (en) 2015-12-03 2021-05-04 Friedrich Miescher Institute For Biomedical Research SYNP159, a promoter for the specific expression of genes in rod photoreceptors
BR112018011059A2 (pt) 2015-12-03 2018-11-21 Friedrich Miescher Institute For Biomedical Research synp161, um promotor para a expressão específica de genes em fotoreceptores de haste
AU2016363830C1 (en) 2015-12-04 2022-03-24 Centre National De La Recherche Scientifique Promoters and uses thereof
WO2017199156A1 (en) 2016-05-17 2017-11-23 Friedrich Miescher Institute For Biomedical Research Novel therapeutic tools and methods for treating blindness
CA3042197A1 (en) 2016-11-02 2018-05-11 Friedrich Miescher Institute For Biomedical Research Synp198, a promoter for the specific expression of genes in direction selective retinal ganglion cells
EP3548093A1 (en) 2016-12-01 2019-10-09 Friedrich Miescher Institute for Biomedical Research Synp107, a promoter for the specific expression of genes in interneurons
JP2020501538A (ja) 2016-12-01 2020-01-23 フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ インターニューロン中の遺伝子の特異的発現のためのプロモーターｓｙｎｐｉ
JP7112414B2 (ja) 2017-02-08 2022-08-03 フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ 網膜神経節細胞中の遺伝子の特異的発現のためのプロモーターｓｙｎｐ８８
CN111726985B (zh) 2017-11-15 2022-06-10 弗里德里克·米谢尔生物医学研究所 灵长类动物视网膜色素上皮细胞特异性启动子
JP2021503934A (ja) 2017-11-30 2021-02-15 フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ 網膜色素上皮中の遺伝子の特異的発現のためのプロモーターＳｙｎＰＩＩＩ
SG11202005002QA (en) 2017-11-30 2020-06-29 Friedrich Miescher Institute For Biomedical Res SynP61, A PRIMATE RETINAL PIGMENT EPITHELIUM CELL-SPECIFIC PROMOTER
US20210388386A1 (en) 2018-10-25 2021-12-16 Friedrich Miescher Institute For Biomedical Research Synp57 (proa14), a promoter for the specific expression of genes in photoreceptors
EP3870238A1 (en) 2018-10-25 2021-09-01 Friedrich Miescher Institute for Biomedical Research Synp17 (prob1), a promoter for the specific expression of genes in retinal ganglion cells
US20210388385A1 (en) 2018-10-25 2021-12-16 Friedrich Miescher Institute For Biomedical Research Synp27 (prob12), a promoter for the specific expression of genes in protoplasmic astrocytes
US20210353773A1 (en) 2018-10-25 2021-11-18 Friedrich Miescher Institute For Biomedical Research Synp194 (prob15), a promoter for the specific expression of genes in retinal ganglion cells
EP3870240A1 (en) 2018-10-25 2021-09-01 Friedrich Miescher Institute for Biomedical Research Synp78 (proa27), a promoter for the specific expression of genes in retinal ganglion cells
WO2020084541A1 (en) 2018-10-25 2020-04-30 Friedrich Miescher Institute For Biomedical Research Synp151 (proc29), a promoter for the specific expression of genes in retinal ganglion cells
US20220119841A1 (en) 2019-01-24 2022-04-21 Friedrich Miescher Instit for Biomedical Research Synp5 (proa9), a promoter for the specific expression of genes in retinal ganglion cells
CN113316643A (zh) 2019-01-24 2021-08-27 弗里德里克·米谢尔生物医学研究所 用于使基因在视网膜神经节细胞中特异性表达的启动子SynP35(ProC8)
WO2020152626A1 (en) 2019-01-24 2020-07-30 Friedrich Miescher Institute For Biomedical Research Synp166 (proa36), a promoter for the specific expression of genes in photoreceptors
EP3914300A1 (en) 2019-01-24 2021-12-01 Friedrich Miescher Institute for Biomedical Research Synp66 (proa21), a promoter for the specific expression of genes in retinal ganglion cells
AU2020229085A1 (en) 2019-02-25 2021-08-19 Friedrich Miescher Institute For Biomedical Research Compositions and methods to treat bietti crystalline dystrophy
JP2022520875A (ja) 2019-02-25 2022-04-01 ノバルティス アーゲー Ｂｉｅｔｔｉクリスタリン網膜症を治療するための組成物及び方法

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AU2017354086C1 (en) 2021-05-06
CN110072557A (zh) 2019-07-30
AU2017354086B2 (en) 2021-01-28
BR112019008488A2 (pt) 2019-07-09
IL266115A (en) 2019-06-30
US11525145B2 (en) 2022-12-13
RU2019115117A3 (https=) 2021-03-23
EP3534966B1 (en) 2024-06-19
RU2019115117A (ru) 2020-12-03
EP3534966A1 (en) 2019-09-11
CA3042197A1 (en) 2018-05-11
JP2019537437A (ja) 2019-12-26
WO2018083607A1 (en) 2018-05-11
AU2017354086A1 (en) 2019-05-09
CN110072557B (zh) 2022-11-11
JP7023279B2 (ja) 2022-02-21

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