KR20190067824A - 아필리모드 조성물 및 이를 알츠하이머병 치료에 사용하기 위한 방법 - Google Patents

아필리모드 조성물 및 이를 알츠하이머병 치료에 사용하기 위한 방법 Download PDF

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Publication number
KR20190067824A
KR20190067824A KR1020197012287A KR20197012287A KR20190067824A KR 20190067824 A KR20190067824 A KR 20190067824A KR 1020197012287 A KR1020197012287 A KR 1020197012287A KR 20197012287 A KR20197012287 A KR 20197012287A KR 20190067824 A KR20190067824 A KR 20190067824A
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South Korea
Prior art keywords
disease
mode
alzheimer
subject
app
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Ceased
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KR1020197012287A
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English (en)
Korean (ko)
Inventor
헨리 리히텐슈타인
조나단 엠. 로스버그
크리스 콘래드
메리렌스 에르난데스
Original Assignee
에이아이 테라퓨틱스, 인코포레이티드
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Application filed by 에이아이 테라퓨틱스, 인코포레이티드 filed Critical 에이아이 테라퓨틱스, 인코포레이티드
Publication of KR20190067824A publication Critical patent/KR20190067824A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020197012287A 2016-10-12 2017-10-11 아필리모드 조성물 및 이를 알츠하이머병 치료에 사용하기 위한 방법 Ceased KR20190067824A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662407186P 2016-10-12 2016-10-12
US62/407,186 2016-10-12
PCT/US2017/056147 WO2018071548A1 (en) 2016-10-12 2017-10-11 Apilimod compositions and methods for using same in the treatment of alzheimer's disease

Publications (1)

Publication Number Publication Date
KR20190067824A true KR20190067824A (ko) 2019-06-17

Family

ID=60268450

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020197012287A Ceased KR20190067824A (ko) 2016-10-12 2017-10-11 아필리모드 조성물 및 이를 알츠하이머병 치료에 사용하기 위한 방법

Country Status (12)

Country Link
US (1) US20190365771A1 (https=)
EP (1) EP3525794A1 (https=)
JP (1) JP7199349B2 (https=)
KR (1) KR20190067824A (https=)
CN (1) CN110167559A (https=)
AU (1) AU2017342262B2 (https=)
BR (1) BR112019007214A2 (https=)
CA (1) CA3039199A1 (https=)
IL (1) IL265911A (https=)
MX (1) MX2019004179A (https=)
RU (1) RU2019113752A (https=)
WO (1) WO2018071548A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202000205A (zh) 2018-02-21 2020-01-01 美商Ａｉ治療公司 使用阿吡莫德與麩胺酸性劑的組合治療
US12589097B2 (en) 2018-02-21 2026-03-31 OrphAl Therapeutics Inc. Apilimod compositions and methods of use
CN116059192B (zh) 2019-11-13 2024-10-29 润佳（苏州）医药科技有限公司 同位素富集的3-氨基-1-丙磺酸及其衍生物的用途
TWI885039B (zh) 2020-01-13 2025-06-01 美商邊際分析公司 經取代吡唑并嘧啶及其用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7923557B2 (en) 2004-11-10 2011-04-12 Synta Pharmaceuticals Corporation Process for preparing trisubstituted pyrimidine compounds
WO2006124662A1 (en) 2005-05-13 2006-11-23 Synta Pharmaceuticals Corp. Il-12 modulatory compounds
WO2006128129A2 (en) 2005-05-26 2006-11-30 Synta Pharmaceuticals Corp. Method for treating cancer
US20130302343A1 (en) * 2011-01-04 2013-11-14 Charité Universitätsmedizin Berlin Modulators of il-12 and/or il-23 for the prevention or treatment of alzheimer's disease
RU2739992C2 (ru) * 2014-11-07 2020-12-30 ЭйАй ТЕРАПЬЮТИКС, ИНК. Композиции апилимода и способы их применения в лечении колоректального рака
CA2966359A1 (en) * 2014-11-07 2016-05-12 Lam Therapeutics, Inc. Apilimod for use in the treatment of renal cancer
WO2016118709A1 (en) * 2015-01-23 2016-07-28 Lam Therapeutics, Inc. Anti-viral compositions containing pikfyve inhibitors and use thereof
WO2016126707A1 (en) * 2015-02-03 2016-08-11 Lam Therapeutics, Inc. Apilimod compositions and methods for using same
US10758545B2 (en) * 2015-06-25 2020-09-01 University Of Southern California Methods to treat neurological diseases

Also Published As

Publication number Publication date
WO2018071548A1 (en) 2018-04-19
RU2019113752A3 (https=) 2021-01-19
AU2017342262A1 (en) 2019-04-18
BR112019007214A2 (pt) 2019-07-02
CA3039199A1 (en) 2018-04-19
JP7199349B2 (ja) 2023-01-05
JP2019530711A (ja) 2019-10-24
RU2019113752A (ru) 2020-11-13
MX2019004179A (es) 2019-09-02
CN110167559A (zh) 2019-08-23
US20190365771A1 (en) 2019-12-05
IL265911A (en) 2019-06-30
EP3525794A1 (en) 2019-08-21
AU2017342262B2 (en) 2023-09-28

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