KR20190049097A - Micro-jet Drug Injection Device with Backflow Prevention Valve - Google Patents

Abstract

The present invention relates to a micro-jet drug injection device with an anti-reflux valve, in which an anti-reflux valve is provided in a housing, filled with a medicinal fluid to be sprayed, such that the medicinal fluid flows only in one direction, thereby preventing the medicinal fluid, having been sprayed through an injection nozzle, foreign substances, and external air from flowing into the housing, and enabling the medicinal fluid to be automatically supplied by the pressure inside the housing. To this end, a separation membrane expands downwards when a pressure generating liquid expands due to laser irradiation such that the medicinal liquid is sprayed in one direction only when a first cut line is opened by the pressure of the separation membrane, thereby preventing the sprayed medicinal liquid, foreign substances, and external air from flowing to a lower space part where the medicinal liquid is placed, and enabling the medicinal liquid to be automatically filled through the injection nozzle as much as discharge by means of the pressure of the lower space part without separate control by a syringe or the medicinal liquid supply housing.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a micro-jet drug injection device having a backflow prevention valve,

The present invention relates to a micro-jet drug injection device, and more particularly, to a micro-jet drug injection device, in which a backflow prevention valve is provided in a housing filled with a chemical liquid to be injected so as to move the chemical liquid only in one direction, And a backflow prevention valve for preventing the outside air from flowing into the housing and automatically supplying the chemical solution by the pressure inside the housing.

In general, syringes are widely used as a method for parenteral administration of a therapeutic drug into a patient's body. The syringe is injected directly into the drug administration site with a needle. Syringes are the most effective way to deliver drugs to patients. However, it causes fear and pain to the patient at the time of injection, and there is a risk of infection due to a wound caused by the needle.

In order to compensate for the disadvantages of such a syringe, a scanning method for delivering a drug to a patient without a needle is being developed. As a part of such studies, a drug delivery system in which a drug is injected at a high speed by a micro jet method and penetrates directly to a target site in the body through a skin epidermis has been proposed.

The micro-jet method requires precise and powerful spraying of the drug towards the skin for high-speed injection. Such high-speed injection has been developed by various injection methods such as a jet method using a piezoelectric ceramic element, a jet method using a shock wave induced by applying a laser beam to an aluminum foil, and a jet method using Lorentz force.

In recent years, unlike the conventional micro jet spraying method, the amount of the injected chemical liquid and the penetration depth of the drug due to the jetting speed of the chemical liquid can be finely adjusted, and the laser-bubble Laser-buble) micro jet injection method has been developed.

The laser-bubble micro jet injection method applies the phenomenon of bubbles generated by the collapse of the liquid structure when a strong energy is concentrated by the laser in the liquid in the closed space. In the sealed chamber partitioned by the separation membrane, the bubbles are generated due to the laser injection, and the total volume increases as the liquid is grown. As a result, the separation membrane is rapidly extended outward to push the chemical liquid out of the nozzle, to be.

However, there is a problem that the edge and the vicinity of the center of the separator are damaged due to the rapid expansion of the separator.

Korean Patent No. 10-1684250 discloses a needle-free syringe which improves the durability of a membrane for partitioning a space for accommodating a chemical solution by reinforcing a fragile portion of the separation membrane for separating the chemical solution accommodating space or forming a double membrane. I have done it.

However, after the chemical liquid is injected, there is a problem that external air or foreign matter flows through the nozzle to interfere with the formation of the micro jet, or contaminate the remaining chemical liquid.

KR 10-1684250 B1 KR 10-1207977 B1

An object of the present invention is to provide a backflow prevention valve at a lower portion of a housing filled with a chemical solution so that the chemical solution is injected only in one direction to prevent foreign air or foreign matter from flowing into the housing through the injection nozzle, And to provide a micro jet drug injection device provided with a non-return valve for automatically supplying a chemical liquid under pressure.

It is another object of the present invention to provide a backflow prevention valve on a passage through which a chemical solution is supplied from the outside to the inside of a housing to allow a chemical solution to flow in only one direction, And a backflow prevention valve that prevents the backflow prevention valve.

Still another object of the present invention is to provide a micro-jet drug injection device provided with a backflow prevention valve that gradually pressurizes a drug solution supply port located on the outside to smoothly and smoothly flow the drug solution into the inside of the housing.

An upper housing 100 having a transparent lens 110 for transmitting energy at its upper end and having a sealed upper cavity 120 to fill the pressure generating liquid 122 therein; A lower space 210 in which a chemical solution 212 is filled and a spray nozzle 220 for spraying the chemical solution 212 are installed at the lower end of the housing 210. A housing, A lower housing 200 in which the lower housing 200 is located; And is configured to divide the pressure generating liquid 122 and the chemical liquid 212 at the boundary between the upper housing 100 and the lower housing 200 with an elastic force and expand downward by irradiation with the laser A separation membrane (300) for transferring pressure to the chemical solution (212); And a nozzle backflow prevention valve (400) located at an inner lower portion of the lower housing (200) to discharge the chemical solution (212) only in one direction outward and to prevent backflow, The pressure generating liquid 122 is inflated by the inflow of energy through the separator 300 and the pressure generating liquid 122 expands and the separator 300 expands downward, As the chemical liquid 212 moves due to the expanding pressure, the opening / closing of the nozzle backflow prevention valve 400 is repeated, and the chemical liquid 212 is injected into the injection nozzle 220, The chemical solution 212 is automatically filled in the lower space portion 210 due to the pressure change occurring in the unit 210.

In addition, the housing located outside the lower housing 200 comprises a syringe 10 having a space for supplying the chemical solution 212.

The housing located outside the lower housing 200 of the present invention is provided with a chemical liquid supply housing 600 including a chemical pouch 620 made of a flexible film for supplying the chemical liquid 212.

The chemical solution supply housing 600 of the present invention has a chemical solution pouch 620 in which the chemical solution 212 is stored and a first pressure application plate 640 is located under the chemical solution pouch 620, The first pressure plate 640 and the second pressure plate 650 are connected to each other by an elastic member 660. The first pressure plate 640 and the second pressure plate 650 are connected to each other by an elastic member 660, The chemical solution 212 is pressurized by the first pressure plate 640 and the second pressure plate 650 due to the contraction of the elastic member 660 along with the pressure change, Lt; RTI ID = 0.0 > 210 < / RTI >

A chemical solution supply port 240 connected to a housing formed on a side surface of the lower housing 200 and allowing the chemical solution 212 to flow into the lower space 210 is formed, (Not shown) to move the chemical solution 212 only in one direction toward the lower space part 210, and to prevent backflow.

The nozzle backflow prevention valve 400 is formed of a material having elasticity and has a first edge 410 fixed to the upper portion of the lower housing 200 so as to be closely contacted with the lower periphery of the lower housing 200, The first slit 420 is formed in a state in which the end of the first slit 420 is spaced apart from the injection nozzle 220 and the pressure generating liquid 122 is inflated at the center of the end of the first slit 420 The first incision 430 is formed by repeating the opening and closing by the pressure to serve as a passage through which the chemical solution 212 escapes.

The supply zone prevention valve 500 of the present invention is formed of a material having elasticity. On the right side, a second rim 510 is formed to be closely attached along the inner circumference of the chemical solution supply port 240, A second slit 520 is formed in the first frame 410 on the right side and narrow on the left side and a second slit 530 is formed in the center of the end of the second slit 520 .

The present invention is characterized in that a nozzle backflow prevention valve 400 is provided below a lower space part 210 in which a chemical solution 212 is sealed in a lower housing 200 and when the pressure generating liquid 122 expands by laser irradiation, The separation membrane 300 is expanded downward and the chemical solution 212 is injected in one direction only when the first incision 430 is opened by the pressure of the separation membrane 300, Foreign matter or foreign air injected into the lower space part 210 is prevented from flowing into the lower space part 210 to prevent contamination of the chemical solution 212 located in the lower space part 210, It is possible to minimize the change in the internal pressure of the nozzle 210 by the pressure of the lower space 210 and to control the flow of the chemical liquid 212 through the injection nozzle 220 without any control by the injector 10 or the chemical liquid supply housing 600 It has the effect of filling up automatically as it exits.

In the process of automatically filling the lower space part 210 with the chemical solution 212 according to the pressure change of the lower housing 200, the chemical pouch 620 is inserted into the lower space part 210 through the first The chemical liquid 212 flows smoothly through the chemical liquid supply pipe 630 to the lower space portion 210 through the chemical liquid supply port 240 and flows smoothly without interruption by pressing the pressure plate 640 and the second pressure plate 650 .

Further, the present invention is not limited to the case where the chemical liquid pouch 620 is formed as a flexible film to easily deform the shape of the liquid pouch 620, 210). ≪ / RTI >

In addition, the present invention is characterized in that the shape of the first section improvement 430 of the nozzle backflow prevention valve 400 is formed into a "C" shape or a "+" shape, and the first section improvement 430 is a " The sealing force for preventing the chemical solution 212 from leaking in the lower space portion 210 can be increased and the durability of the first section improvement 430 can be maintained for a long period of time even if the first section reduction 430 is repeatedly opened and closed.

In the meantime, according to the present invention, the supply space flow prevention valve 500 is installed in the chemical solution supply port 240 connected to the syringe 10 or the chemical solution supply housing 600, so that the pressure generated in the lower space portion 210 is transmitted to the syringe 10 and the chemical liquid supply housing 600 so as to be concentrated toward the injection nozzle 220 provided at the lower portion of the lower space 210 so that the chemical liquid 212 is injected at a higher speed There is an effect that can be done.

1 is an isometric perspective view of a micro-jet drug injection device with a check valve according to a first embodiment of the present invention;
FIG. 2 is a cross-sectional view of a micro-jet drug injection device provided with a check valve according to the first embodiment of the present invention. FIG.
FIG. 3 is a cross-sectional view showing injection of the chemical liquid 212 of the micro-jet drug injection device provided with the check valve according to the first embodiment of the present invention.
4 is a bottom view showing an arrangement of the injection openings 222 in the micro jet drug injection device provided with the check valve according to the first embodiment of the present invention.
FIG. 5 is a bottom view showing various forms of the nozzle backflow prevention valve 400 in the micro jet drug injection device provided with the backflow prevention valve according to the first embodiment of the present invention.
FIG. 6 is an isometric perspective view of a micro-jet drug injection device provided with a check valve according to a second embodiment of the present invention; FIG.
FIG. 7 is an exploded perspective view of a micro-jet drug injection device provided with a check valve according to a second embodiment of the present invention; FIG.
8 is a cross-sectional view of a micro-jet drug injection device provided with a check valve according to a second embodiment of the present invention.
9 is an isometric view of the chemical supply housing 600 of FIG.
10 is a cross-sectional view showing injection of the chemical liquid 212 of the micro jet drug injection device provided with the check valve according to the second embodiment of the present invention.
FIG. 11 is an isometric perspective view showing the chemical supply housing 600 of FIG. 10; FIG.

Hereinafter, preferred embodiments of the present invention will be described with reference to the accompanying drawings so that those skilled in the art can easily carry out the present invention.

FIG. 1 is a perspective view of a micro-jet drug injection device provided with a check valve according to a first embodiment of the present invention, FIG. 2 is a perspective view of a micro-jet drug delivery device equipped with a check valve according to the first embodiment of the present invention, FIG. 3 is a cross-sectional view showing the injection of the chemical liquid 212 of the micro jet drug injection device provided with the check valve according to the first embodiment of the present invention, FIG. 4 is a cross-sectional view illustrating the reverse flow according to the first embodiment of the present invention. FIG. 5 is a bottom view showing the arrangement of the injection ports 222 in the micro-jet drug injection device provided with the anti-backflow valve, FIG. 5 is a bottom view of the nozzle backflow prevention valve in the micro-jet drug injection device provided with the anti-reverse flow valve according to the first embodiment of the present invention, And FIG. 4 is a bottom view showing various forms of the battery 400.

The upper housing 100 is formed into a hollow rod shape with open upper and lower ends. A projection lens 110 for laser irradiation or radio wave transmission is provided at the upper end of the upper housing 100. The upper end of the upper housing 100 is airtightly closed by the projection lens 110. [ The projection lens 110 is formed of a convex lens with a cross section. At this time, the projection lens 110 can be formed to be concave if the projection of the laser is possible.

The upper housing 100 also serves as a handle that the user can hold by hand during the procedure.

In the upper housing 100, an upper hollow 120 is formed. The upper hollow portion 120 is filled with the pressure generating liquid 122. As the pressure generating liquid 122, general water may be used, and various liquid substances such as polymer sol and gel, such as alcohol and polyethylene glycol, may be used.

In addition, it is preferable that the pressure generating liquid 122 be a gas from which gas has been removed in order to minimize residual bubbles when bubbles are generated by the laser. Further, when the electrolytic solution such as salt is added to the pure water, the pressure generating liquid 122 can ionize the molecules and reduce the energy required to collapse the molecular structure of the liquid, thereby improving the bubble with better efficiency. Therefore, it is more preferable to use an electrolyte added to pure water.

An upper membrane fixing groove 130 for fixing a separation membrane 300, which will be described later, is formed around the lower end inner periphery of the upper housing 100.

Meanwhile, as shown in FIG. 3, the apparatus may further include an energy concentrator 20 capable of concentrating energy toward a specific point of the upper hollow portion 120 filled with the pressure generating liquid 122.

The energy concentration device 20 refers to a device capable of concentrating energy using a microwave, a laser, or the like. The energy concentration apparatus 20 concentrates energy such as a laser in the pressure generating liquid 122 and pushes the separation membrane 300 downward by the instantaneous volume expansion due to the evaporation of the pressure generating liquid 122 and the transmission of shock waves And the chemical solution 212 filled in the lower space 210 by the separation membrane 300 is pushed to the injection nozzle 220 to generate a micro jet such that the chemical solution 212 penetrates the skin.

The lower housing 200 is formed into a hollow rod shape having open upper and lower ends. At this time, the lower end is made to be relatively narrow like a cone. The upper housing 100 is detached from the lower housing 200 at the lower end thereof. The lower housing 200 may be designed to be integrally formed with the upper housing 100 according to a design.

A lower space portion 210 is formed in the lower housing 200. The lower space portion 210 is filled with the chemical solution 212. Various types of the chemical solution 212 may be used depending on the purpose of the treatment.

A spray nozzle 220 is installed at a lower end of the lower space 210. The injection nozzle 220 may be integrally formed with the lower housing 200 or may be separately installed to be removable. The injection nozzle 220 can be easily replaced when it is contaminated or clogged by a breakage or foreign matter. The injection nozzle 222, which is a hole through which the chemical liquid 212 is injected, is punctured in the injection nozzle 220.

At this time, the injection port 222 may be formed of a plurality of holes instead of one hole. That is, a plurality of injection openings 222 may be formed in one injection nozzle 220. When forming the jetting ports 222 in plural, it is preferable that the jetting ports 222 are formed by 2 to 9 independent holes. When a plurality of the injection ports 222 are formed, the drug can be injected into the wide ring portion with one injection of the chemical liquid 212, thereby shortening the procedure time.

Further, the jetting ports 222 may be formed in a tapered shape so that the area becomes narrower from the upper side to the lower side.

4, the injection ports 222 formed in the injection nozzle 220 may be arranged in a regular polygonal arrangement. The plurality of injection openings 222 are arranged in a regular polygonal arrangement so that the distance is constant so that the chemical liquids 212 are injected into the skin at regular intervals.

4, four injection openings 222 are arranged in a square array. However, the injection openings 222 may be polygonal such as rhombus, triangular, pentagonal, or hexagonal, as long as the chemical liquid 212 can be injected into the skin at even intervals.

Meanwhile, the injection nozzle 220 may be formed of a zirconia material, which is a zirconium-based ceramic. At this time, zirconium oxide is used as zirconium. Since zirconium oxide has a high rupture toughness and has very high resistance to crack propagation, it is possible to prevent the end of the injection nozzle 220 from being broken or deformed when the chemical liquid 212 is sprayed.

The lower part of the lower housing 200 including the injection nozzle 220 may be made of various materials such as stainless steel, aluminum alloy, and zirconium based ceramic material, if the chemical liquid 212 can be injected smoothly. Further, only the lower portion of the lower housing 200 can be made of a zirconium-based ceramic material through insert injection. When the injection nozzle 220 is made separately from the lower housing 200, the injection nozzle 220 is detachably attached to the lower end of the lower housing 200. Therefore, when the injection nozzle 220 is broken or when the diameter of the injection port 222 is to be changed, it can be used in the lower housing 200 for replacement.

The injection port 222 is formed to have a diameter of 50 to 250 micrometers. When the injection port 222 is less than 50 micrometers, there is a problem that the amount of the chemical liquid 212 to be injected is small and the chemical liquid 212 is not injected into the body to a sufficient depth. When the jetting port 222 is more than 250 micrometers, the diameter of the injected medicament 212 becomes large, which increases the amount of the drug repelled from the surface of the skin and wastes the drug.

Among the zirconium-based ceramic materials, zirconium oxide (zirconia) has a low thermal conductivity, so it can prevent deterioration of the chemical liquid 212 due to heat transfer during laser irradiation, has a high rupture toughness, and has very high resistance to crack propagation. Therefore, it is preferable that the lower portion of the lower housing 200 including the injection nozzle 220 is formed of zirconium oxide (zirconia) among ceramic materials of zirconium series in order to prevent breakage or deformation.

In the lower or entire section of the lower housing 200, there may be included a plurality of sections in which the horizontal cross-sectional area increases toward the upper direction and the slope of the inner wall is constant for each predetermined section, and the inclination of the inner wall decreases toward the upper direction.

In addition, the lower or entire section of the lower housing 200 may be formed in a trumpet shape extending in a curved shape from the injection nozzle 220 side toward the upper housing 100 side. Therefore, the pressure delivered from the separation membrane 300, which will be described later, can be more concentrated to push the chemical liquid 212 toward the injection nozzle 220, and the chemical liquid 212 injected to the injection nozzle 220 can be concentrated at a higher speed Lt; / RTI >

On the other hand, a syringe inserting hole 230 for inserting the syringe 10 is protruded from the lower side of the lower housing 200. The syringe 10 is installed in the syringe insertion port 230 to supplement the chemical solution 212 to the lower space portion 210. In the syringe insertion port 230, a fixing groove 232 to which the tip of the syringe 10 is fixed is engaged. At this time, the fixing grooves 232 are drawn in a diagonal direction.

At the lower end of the fixing groove 232, a chemical liquid supply port 240 is formed to communicate with the lower space portion 210. The drug solution 212 contained in the injector 10 flows into the lower space 210 through the drug solution supply port 240. The chemical solution supply port 240 is provided with a supply section flow prevention valve 500 to be described later.

A separate contact guide 250 may be provided at the lower end of the lower housing 200 so that the patient can be brought into close contact with the skin during the operation. The contact guide 250 is made of a transparent material having a cylindrical shape with upper and lower portions opened. The lower end of the contact guide 250 is formed so as to be partially folded for smooth contact with the skin.

Further, a lower film fixing groove 260 for fixing the separating film 300, which will be described later, is formed around the upper end inner periphery of the lower housing 200.

The separation membrane 300 is installed between the lower end of the upper housing 100 and the upper end of the lower housing 200 and includes an upper hollow portion 120 filled with the pressure generating liquid 122 and a lower hollow portion 210). The separation membrane 300 is made of a silicon rubber material as a thin film having elasticity.

The separation membrane 300 separates the lower end of the upper housing 100 and the upper end of the lower housing 200 so that the pressure generating liquid 122 filled in the upper hollow 120 is hermetically sealed. In addition, the chemical liquid (212) filled in the lower space portion (210) is airtightly sealed. The separation membrane 300 is positioned at the connection portion between the upper housing 100 and the lower housing 200 when the upper housing 100 and the lower housing 200 are detachable.

In addition, the separation membrane 300 may be damaged due to rapid expansion due to edge and center. Therefore, it is preferable that the separator 300 reinforce the edge and the vicinity of the center.

The separating film 300 can transfer the pressure acting on the pressure generating liquid 122 filled in the upper hollow portion 120 to the chemical solution 212 filled in the lower space portion 210, May also be configured.

When the laser is irradiated on the pressure generating liquid 122, bubbles are generated in the pressure generating liquid 122 and the volume of the pressure generating liquid 122 is increased. Then, the separator 300 expands downward. In this state, when the bubble in the pressure generating liquid 122 disappears, the separation membrane 300 moves upward and becomes parallel. In this process, when the separation membrane 300 moves downward, the chemical liquid 212 is injected toward the injection nozzle 220.

The nozzle backflow prevention valve 400 prevents the once injected chemical liquid 212 from flowing back into the lower space portion 210 while the chemical liquid 212 is injected toward the injection nozzle 220, To the lower space portion 210. [0052] As shown in FIG. The nozzle backflow prevention valve 400 is made of a material having elasticity as a whole. For example, a material such as rubber or silicone may be used.

The nozzle backflow prevention valve 400 is hermetically fixed to the first rim 410 in a circular ring shape along the lower inner circumference of the lower housing 200. The first slit 420 is formed so as to extend in the shape of an upper light-tight narrowing at the first edge 410. The first rim 410 and the first slit 420 are integrally formed. In addition, the first slit 420 is formed to have an arc-shaped cross section as a whole. In addition, the nozzle backflow prevention valve 400 may be formed in a shape in which the first slit 420 or the entire shape of the first slit 420 is closed like a beak of a duck or a flute.

The lower end of the first slit 420 is spaced apart from the injection nozzle 220. A first slit 430 is formed at the center of the first slit 420. The upper end of the chemical solution 212 is sealed by the separation membrane 300 in the lower space portion 210 and the lower end is sealed by the nozzle backflow prevention valve 400.

As described above, when the entire volume of the pressure generating liquid 122 is increased by irradiation of the laser, the separation membrane 300 expands downward, and the chemical solution 212 moves downward according to the pressure of the separation membrane 300 . In this process, the first section improvement 430 is performed and the chemical solution 212 is moved into the gap formed in the first section improvement 430. [ That is, the first section improvement 430 serves as a passage through which the chemical solution 212 escapes. The transferred chemical liquid 212 is injected to the outside through the injection port 222 formed in the injection nozzle 220. The injected drug solution 212 penetrates directly into the skin.

The first improvement 430 is kept closed and temporarily opened only when the chemical liquid 212 is injected under the pressure of the separation membrane 300 and then closed. In other words, if the chemical liquid 212 in the lower housing 200 is discharged to the first incision 430 and the injection port 222, the internal pressure of the lower housing 200 is lowered. In this state, the first incision 430 is closed by the restoring force of the first slit 420. Therefore, the chemical liquid injected by the injection nozzle 220 is prevented from flowing back to the inside of the lower space portion 210, and foreign matter and inflow of external air are prevented. That is, since the chemical solution 212 located in the lower space 210 is discharged only in one direction, the inflow of the chemical solution, the foreign matter and the external air already injected into the lower space 210 is blocked, and the chemical solution 212 ) Can be prevented.

In addition, the inside of the lower space part 210 is in a state close to vacuum. When a part of the chemical solution 212 is released, the chemical solution 212 located in the chemical solution cylinder 12 of the syringe 10 And automatically flows into the lower space portion 210. At this time, the plunger 14 of the syringe 10 also automatically moves downward.

The chemical solution 212 located in the chemical solution cylinder 12 is automatically introduced into the lower space portion 210 through the chemical solution supply port 240 while repeating the laser irradiation.

Meanwhile, the shape of the first cut-away portion 430 formed at the lower portion of the first slit 420 may be various shapes as shown in FIG.

In FIG. 5 (a), the shape of the first section improvement 430 is a "one" shape.

(b) shows the shape of the first section improvement 430 in a " C " shape. (b), when the first section improvement 430 is formed in a " C " shape, the first section improvement 430 (see FIG. It is possible to increase the sealing force so as not to open. Also, in the case of (b), the durability can be increased so as to increase the period during which the first section improvement (430) does not occur during normal use even if the unit is continuously used for a longer period of time. In (b), the material of the portion near the center of the " C " shape in the first section improvement 430 is made of a material having a smaller elastic modulus than the material of the outer portion. This is to make the first incision 430 open more easily due to the pressure caused by the expansion of the pressure generating liquid 122. At this time, it is preferable that the ratio of the modulus of elasticity is 0.6 to 0.9 near the center of the first section improvement 430 and the outer section is 1.

(c), the first section improvement 430 is formed in a " + " shape. In this case, as compared with the "one" shape of (a), not only the pressing force is increased so as to prevent the first incision 430 from being opened, but also the center of the first incision 430 As shown in FIG. In this way, the maximum length of the first section improvement 430 can be minimized, so that the first slit 420 can be positioned close to the injection nozzle 220.

In addition, even if the injection nozzle 220 having a plurality of injection ports 222 is used, the drug can be pushed out to the respective injection ports 222 with a uniform pressure. In addition, the durability can also be increased so that the period in which the first folding section 430 is kept from being opened normally even when it is continuously used for a longer period of time as compared with the " one "

In addition, since the injection port 222 is formed in a taper shape having a smaller horizontal cross-sectional area toward the lower end, the expansion pressure of the separation membrane 300 is concentrated at the injection port 222, and the injection speed of the chemical liquid 212 can be increased.

The supply section prevention valve 500 is provided in the chemical solution supply port 240 to prevent the chemical liquid that has escaped from the syringe 10 from flowing back into the syringe 10 again. The supply section flow prevention valve 500 is made of a material having elasticity as a whole. For example, a material such as rubber or silicone may be used.

A check valve may be used as the supply section flow prevention valve 500, but various valves may be used as long as they can prevent back flow, such as the nozzle backflow prevention valve 400.

The supply section flow prevention valve 500 may be constructed in the same structure as the nozzle backflow prevention valve 400.

The supply section prevention valve 500 is airtightly fixed to the second rim 510 in the shape of a circular ring along the inner periphery of the chemical solution supply port 240. And the first slit 420 is formed so as to extend in a downwardly downwardly symmetrical shape in the second edge 510. The second frame 510 and the second slot 520 are integrally formed. At this time, the second slit 520 is formed so as to have a circular arc as a whole. The lower end of the second slit 520 is spaced apart from the injection nozzle 220. A second section 530 is formed at the center of the second slot 520. The chemical liquid 212 inside the syringe 10 is partitioned from the lower space portion 210 by the supply space flow prevention valve 500.

When the total volume of the pressure generating liquid 122 is increased by the laser irradiation, the separation membrane 300 expands downward and the chemical solution 212 located in the lower space 210 is also pressurized by the pressure of the separation membrane 300 And moves in the downward direction. In this process, the second section improvement 530 is performed with the first section improvement 430 and the chemical solution 212 of the syringe 10 is injected into the gap formed in the second section improvement 530 in the lower space portion 210 ). In other words, the chemical solution 212 is newly introduced through the second incision 530 as it is injected to the outside by the first incision improvement 430.

The second improvement 530 is temporarily opened and closed only when the chemical liquid 212 is injected under the pressure of the separation membrane 300 by the elastic force. Thus, the chemical solution 212 inside the lower space portion 210 is prevented from flowing back toward the chemical solution supply port 240 side. That is, since the chemical liquid 212 located in the syringe 10 flows into the lower space 210 only in one direction, the chemical liquid 212 located in the lower space 210 is prevented from flowing into the syringe 10 And the contamination of the chemical solution 212 located in the syringe 10 can be prevented. The drug solution 212 of the syringe 10 is continuously introduced into the lower space portion 210 as much as the drug solution 212 is injected to the outside in the lower space portion 210. Thereby continuously supplying the chemical solution 212 to the lower space part 210, so that a certain amount of the chemical solution 212 is injected through the injection nozzle 220.

Further, the injector 10 is a system in which the chemical liquid 212 is stored in the chemical liquid cylinder 12, and the chemical liquid 212 is discharged to the outside as the plunger 14 is pushed. Even if the syringe 10 is inserted into the syringe insertion port 230, the plunger 14 moves downward due to the pressure of the lower space portion 210 so that the liquid medicine 212 in the chemical liquid cylinder 12 flows into the lower space portion (210).

The shape of the second cutout 530 formed at the lower portion of the second slit 520 may be various shapes as shown in FIG.

FIG. 2 is a transverse cross-sectional view of a micro-jet drug injection device provided with a check valve according to a first embodiment of the present invention. FIG. 3 is a cross- And is a cross-sectional view showing injection of the chemical solution 212.

FIG. 2 shows the state before the chemical liquid 212 is injected through the injection nozzle 220, and FIG. 3 shows that the chemical liquid 212 is injected through the injection nozzle 220.

The pressure generating liquid 122 located in the upper hollow 120 remains in the original state when the laser is not irradiated through the projection lens 110. In addition, the separation membrane 300 is maintained in a parallel state. The first section improvement 430 of the nozzle backflow prevention valve 400 and the second section improvement 530 of the supply section flow prevention valve 500 are kept closed.

When the laser is irradiated through the projection lens 110, a plurality of bubbles are generated in the pressure generating liquid 122 located in the upper hollow 120, and the total volume of the pressure generating liquid 122 is increased by bubbles. The separation membrane 300 separating the upper hollow portion 120 and the lower space portion 210 is expanded in the downward direction. Then, the chemical solution 212 located in the lower space part 210 moves downward by the pressure of the separation membrane 300. The first incision 430 of the nozzle backflow prevention valve 400 is opened by the pressure of the chemical solution 212 to move and the chemical solution 212 exiting the first incision 430 is guided to the injection nozzle 220 To the skin.

In the course of this process, the second section improvement 530 is also opened. In the chemical solution cylinder 12 of the syringe 10 as much as the drug solution 212 that has passed through the first section improvement 430, .

When the chemical liquid 212 is discharged through the injection nozzle 220, the chemical liquid 212 located in the chemical liquid cylinder 12 of the syringe 10 connected to the chemical liquid supply port 240 automatically flows into the lower space 210, Lt; / RTI > That is, the chemical liquid 212 is filled into the lower space part 210 by the syringe 10 as the chemical liquid 212 escapes to the injection nozzle 220 without any separate control.

A description will be given of a process in which the chemical liquid 212 is injected through the injection nozzle 220 and replenished by the injector 10. The chemical liquid injected from the chemical liquid cylinder 12 of the injector 10 212 are introduced into the lower space 210 and the chemical solution 212 inside the lower space 210 through the injection nozzle 220 can be injected into the micro jet.

After the chemical liquid 212 is injected, the chemical liquid 212 injected to the injection nozzle 220 by the nozzle backflow prevention valve 400, the foreign matter and the external air are prevented from flowing into the lower space portion 210, The chemical solution 212 of the chemical solution cylinder 12 is filled in the lower space part 210 again by the pressure reduced by the spraying of the chemical solution 212. [ In this circulation process, the chemical solution 212 can be automatically filled into the lower space portion 210 without any separate power supply or control for supplementing the separate chemical solution 212.

As a result, the chemical solution 212 is jetted by the jet nozzle 220 every time the laser is irradiated, and the procedure is repeated while the chemical solution 212 is repeatedly filled by the injector 10.

The second embodiment replaces the supply of the chemical solution 212 to the lower space portion 210 with the chemical solution supply housing 600 instead of the syringe 10 in the first embodiment. The second embodiment includes the contents of the first embodiment. In the following description of the second embodiment, the description of the configuration which is the same as the first embodiment will be omitted.

FIG. 6 is an isometric perspective view of a micro-jet drug injection device provided with a check valve according to a second embodiment of the present invention, and FIG. 7 is a cross-sectional view of the micro- Fig. In FIG. 7, the gauge window 670 is omitted.

A box-like chemical liquid supply housing 600 is provided outside the lower housing 200. In the lower housing 200, a housing fixing groove 270 is formed for installing the chemical liquid supply housing 600. The housing fixing groove 270 is flattened to the lower outside of the lower housing 200.

An upper fixing groove 272 is formed on the upper side of the housing fixing groove 270, and a lower fixing groove 274 is formed on the lower side of the housing fixing groove 270. The upper fixing groove 272 and the lower fixing groove 274 are for detachment of the chemical liquid supply housing 600.

The chemical liquid supply housing 600 is for continuously supplying the chemical liquid 212 to the lower space portion 210. The box-shaped storage housing 610 is detachably attached to the housing fixing groove 270 described above. The storage housing 610 is formed in a hollow shape. A fixture 612 protrudes from the lower part of the storage housing 610, and a 'b' shaped protrusion 614 protrudes from the lower part. The chemical liquid supply housing 600 can be attached to and detached from the housing fixing groove 270 through the fixture 612 and the locking protrusion 614. [ At this time, the storage housing 610 is fixed by inserting the locking protrusion 614 into the lower fixing groove 274 first and then fixing the fixing hole 612 to the upper fixing groove 272. The locking protrusion 614 is loosely inserted into the lower fixing groove 274 and the fixing hole 612 is tightly coupled with the upper fixing groove 272. [

A medicine pouch 620 is located inside the storage housing 610. The drug solution pouch 620 is made in the form of a thin rubber or silicone bag having elasticity. The chemical solution pouch 620 is filled with the chemical solution 212. The liquid medicine pouch 620 is sealed so that the inner liquid medicine 212 is not deteriorated.

A cover 616 is provided on the upper portion of the storage housing 610 so as to be opened and closed. The lid 616 may be formed integrally with the storage housing 610. The storage housing 610 is formed with a supply pipe hole 618 through which a chemical liquid supply pipe 630 to be described later can be exposed to the outside.

A pouch hole 622 is formed through the side surface of the medicament pouch 620. In the pouch hole 622, a chemical liquid supply pipe 630 is provided. The drug solution supply pipe 630 is a tube having an inner hollow shape. The start end of the drug solution supply pipe 630 is connected to the drug solution pouch 620 and the end of the drug solution supply pipe 630 is connected to the drug solution supply port 240 formed in the lower space part 210. The chemical liquid supply pipe 630 is made of an elastic material such as rubber or silicone.

On the bottom surface of the storage housing 610, the first pressure plate 640 is placed in a thin plate shape so as to be in contact with the lower surface of the chemical pouch 620. In addition, a thin plate-shaped second pressure plate 650 is placed below the lid 616 of the storage housing 610 so as to be in contact with the upper surface of the chemical pouch 620.

A ring-shaped first ring 642 is protruded from both sides of the first pressure plate 640. In addition, ring-shaped second rings 652 are formed on both sides of the second pressure plate 650 so as to be in line with the first rings 642.

An elastic member 660 is provided between the first ring 642 and the second ring 652. Both ends of the elastic member 660 are fixed to the first ring 642 and the second ring 652 by compression springs, respectively. And the elastic member 660 is fixed between the first ring 642 and the second ring 652 in an elongated state. Thus, the elastic member 660 has a property of continuously contracting. The first presser plate 640 and the second presser plate 650 are pressed from both sides of the medicine pouch 620 by the contraction of the elastic member 660. As the first pressurizing plate 640 and the second pressurizing plate 650 press the drug pouch 620, the drug solution 212 located inside the drug solution pouch 620 is uniformly discharged through the drug solution supply pipe 630 .

On the other hand, a gauge window 670 is formed on the side surface of the storage housing 610. The gauge window 670 is made by cutting a part of the side surface of the storage housing 610. The remaining amount of the chemical liquid 212 in the chemical liquid pouch 620 can be visually confirmed through the gauge window 670. [

FIG. 8 is a cross-sectional view of a micro-jet drug injection device provided with a check valve according to a second embodiment of the present invention, FIG. 9 is an isometric view of the drug solution supply housing 600 of FIG. 8, FIG. 11 is a two-dimensional perspective view showing the chemical liquid supply housing 600 of FIG. 10; FIG. 11 is a cross-sectional view showing the injection of the chemical liquid 212 of the micro jet drug injection device provided with the check valve according to the second embodiment of FIG.

FIG. 8 shows the state before the chemical liquid 212 is injected through the injection nozzle 220, and FIG. 10 shows that the chemical liquid 212 is injected through the injection nozzle 220.

The pressure generating liquid 122 located in the upper hollow portion 120 remains unchanged when the laser beam is not irradiated through the projection lens 110. [ In addition, the separation membrane 300 is maintained in a parallel state. The first section improvement 430 of the nozzle backflow prevention valve 400 and the second section improvement 530 of the supply section flow prevention valve 500 are kept closed.

When the laser is irradiated through the projection lens 110, a plurality of bubbles are generated in the pressure generating liquid 122 located in the upper hollow 120, and the total volume of the pressure generating liquid 122 is increased by bubbles. The separation membrane 300 separating the upper hollow portion 120 and the lower space portion 210 is expanded in the downward direction. Then, the chemical solution 212 located in the lower space part 210 moves downward by the pressure of the separation membrane 300.

The first incision 430 of the nozzle backflow prevention valve 400 is opened by the pressure of the chemical solution 212 to move and the chemical solution 212 exiting the first incision 430 is guided to the injection nozzle 220 To the skin.

The second section improvement 530 is also opened in this process and the chemical solution 212 which has passed through the first section improvement 430 is supplied to the lower space part 210 through the chemical solution supply pipe 630.

At this time, the first pressurizing plate 640 and the second pressurizing plate 650 are pressurized due to the contraction of the elastic member 660, so that the medicament liquid 212 located inside the medicament pouch 620 smoothly escapes. That is, the upper and lower portions of the chemical pouch 620 are simultaneously pressed by the first pressure plate 640 and the second pressure plate 650, so that the chemical liquid 212 smoothly flows through the chemical liquid supply pipe 630 to the chemical liquid supply port 240 And then flows into the lower space portion 210.

On the other hand, the negative pressure generated when the chemical liquid 212 is injected into the injection nozzle 220 may cause a resistance that is difficult to be naturally filled in the chemical liquid pouch 620. Then, by the negative pressure, the chemical solution 212 of the chemical pouch 620 is filled in the lower space portion 210, so that a part of the lower space portion 210 can be in a vacuum state. This prevents the liquid medicine 212 from being filled into the lower space portion 210 and also prevents the liquid medicine 212 from being supplied to the lower space portion 210 because the microfluid of the liquid medicine 212 injected from the injection nozzle 220 It may cause deterioration of quality.

In order to solve this problem, it is preferable that the liquid medicine pouch 620 is formed of a flexible film. As the flexible film, it is preferable to use a material such as low molecular weight polyethylene (LDPE), polypropylene (PP), nitrile butadiene (NBR), ethylene propylene diene monomer (EDPM) . This is to facilitate shape deformation of the medicine pouch 620.

Further, the drug solution pouch 620 can be made of a transparent or translucent material. Accordingly, the remaining amount of the drug pouch 620 can be easily determined by the gauge window 670 described above.

Meanwhile, the chemical liquid supply housing 600 may be detached while maintaining the lower housing 200 as it is, or may be used by replacing the chemical liquid supply housing 600 and the lower housing 200 at the same time. When the chemical liquid supply housing 600 is to be replaced in the lower housing 200, the chemical liquid supply pipe 630 is removed from the chemical liquid supply port 240 formed in the lower housing 200, The supply pipe 630 can be replaced by a method of inserting the supply pipe 630 into the chemical liquid supply port 240.

10: Syringe
12: Chemical liquid cylinder 14:
20: Energy Concentrator
100: upper housing
110: light projecting lens 120: upper hollow portion 122: pressure generating liquid
130: upper film fixing groove
200: Lower housing
210: lower space part 212: chemical solution
220: jet nozzle 222: jet nozzle
230: Syringe insertion port 232: Fixing groove
240: chemical liquid supply port 250: contact guide 260: lower film fixing groove
270: Housing fixing groove 272: Upper fixing groove 274: Lower fixing groove
300: membrane
400: Nozzle backflow prevention valve
410: first frame 420: first slit 430: section 1 improvement
500: Supply section flow prevention valve
510: second border 520: second slit 530:
600: chemical solution supply housing
610: Storage housing
612: fixture 614: latching protrusion 616: lid 618: supply pipe hole
620: chemical pouch 622: pouch hole
630: chemical solution supply pipe
640: first pressure plate 642: first ring
650: second pressure plate 652: second ring 660: elastic member
670: Gauge window

Claims (7)

An upper housing 100 provided with a projection lens 110 for energy transmission at an upper end thereof and having an upper space 120 sealed therein so as to be filled with the pressure generating liquid 122;
A lower space 210 in which a chemical solution 212 is filled and a spray nozzle 220 for spraying the chemical solution 212 are installed at the lower end of the housing 210. A housing, A lower housing 200 in which the lower housing 200 is located;
And is configured to divide the pressure generating liquid 122 and the chemical liquid 212 at the boundary between the upper housing 100 and the lower housing 200 with an elastic force and expand downward by irradiation with the laser A separation membrane (300) for transferring pressure to the chemical solution (212); And
And a nozzle backflow prevention valve (400) located at an inner lower portion of the lower housing (200) to discharge the chemical solution (212) only in one direction toward the outside and prevent reverse flow,
The pressure generating liquid 122 is inflated by the inflow of energy through the projection lens 110 and the separation membrane 300 expands downward due to the pressure of the pressure generating liquid 122 expanding, As the chemical liquid 212 moves due to the expansion pressure of the separation membrane 300, the opening and closing of the nozzle backflow prevention valve 400 is repeated, and the chemical liquid 212 is injected into the injection nozzle 220 And a backflow prevention valve that automatically fills the lower space part (210) with the chemical solution (212) due to a pressure change in the lower space part (210).
The method according to claim 1,
Wherein the housing located outside the lower housing (200) comprises a syringe (10) having a space for supplying the chemical liquid (212).
The method according to claim 1,
The housing located on the outside of the lower housing 200 is provided with a liquid supply housing 600 including a liquid pouch 620 made of a flexible film for supplying the liquid medicine 212, Jet drug delivery device.
The method of claim 3,
The chemical liquid supply housing 600
A first presser plate 640 is positioned below the drug solution pouch 620 and a second presser plate 620 is disposed on the drug solution pouch 620. The first presser plate 640 is located below the drug solution pouch 620, 650 are disposed on the first and second pressing plates 640 and 640. The first and second pressing plates 640 and 650 are connected to each other by an elastic member 660,
The pressure of the first fluid pressure plate 640 and the pressure of the second pressure pad 650 due to the contraction of the elastic member 660 together with the change in the pressure in the lower space part 210 causes the medicament liquid 212 And a backflow prevention valve that is automatically filled in the lower space part (210) through the valve body (620).
The method according to claim 2 or 3,
A chemical solution supply port 240 connected to a housing formed on a side surface of the lower housing 200 and allowing the chemical solution 212 to flow into the lower space 210,
And a supply space flow prevention valve (500) for causing the chemical solution (212) to move only in one direction toward the lower space part (210) and preventing reverse flow on the chemical solution supply port (240) A micro-jet drug delivery device with a valve.
The method according to claim 1,
The nozzle backflow prevention valve 400 is formed of a material having elasticity and has a first edge 410 fixed to the upper portion of the lower housing 200 so as to be closely contacted with the lower periphery of the lower housing 200, The first slit 420 is formed in a state in which the end of the first slit 420 is spaced apart from the injection nozzle 220 and the pressure generating liquid 122 is inflated at the center of the end of the first slit 420 And a first incision (430) which is opened and closed repeatedly by pressure to serve as a passage through which the drug solution (212) escapes.
6. The method of claim 5,
The supply-space preventing valve 500 is made of a material having elasticity, and on the right side is formed a second rim 510 which is fixed so as to be closely adhered along the inner circumference of the chemical liquid supply port 240, A second slit 520 is formed on the right side of the second slit 520 and a second slit 520 is formed on the left side of the second slit 520. The second slit 520 has a second slit 530 formed at the center of the end of the second slit 520, Equipped micro-jet drug injection device.

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