JP2011147663A - Catheter, and medicine administration device - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a catheter, and a medicine administration device, capable of correctly administrating a minute quantity of medicine. <P>SOLUTION: The device includes a catheter 3 to administer medicine as pierced into a living body tissue of a mammal such as a human, which is a thin and long member 8 having a lumen 9 inside and a through hole 10 to connect the lumen 9 to the external, a non-transparent elastic sheet 11 covering the through hole 10, and a pressure-permeable hard outer member 12 which covers the through hole 10 from the outer side of the non-transparent elastic sheet 11 and to which the chemical is permeable in a pressurized state. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to a catheter and a drug administration device that are punctured into a living tissue of a mammal including a human and administer a drug.

  Conventionally, in the medical field, a medical practice of directly injecting a drug into a living tissue using a syringe or the like has been performed. Here, even if the drug is injected into the blood vessel in units of several hundred milliliters, it does not leak, whereas the amount of the drug that can be administered to a living tissue such as an organ is about several tens of microliters. It is set to a very small amount. The dose of the drug depends on the absorption rate of the chemical solution in the living tissue such as the organ, and if the drug is administered in excess of the dose that can be administered, the drug leaks out of the organ and the skin outside the body and the healthy body This is because the drug touches the organ. Actually, in an organ or the like, the amount that can be administered at one time for a solid tumor or the like is about several tens of microliters, and if injected at a dosage exceeding about 100 microliters, leakage occurs. For this reason, only a small amount of drug can be administered to a living tissue such as an organ at a time.

  On the other hand, since some tumors exist in a relatively deep place in the body, it is not uncommon for the syringe part outside the body and the discharge part at the tip punctured to the tumor part inside the body to be separated by several tens of centimeters. In such a case, for example, if 10 μL of the drug solution is to be flowed through a tube having an inner diameter of 1 mm, the length of the drug in the tube is only about 12.7 mm, and from this length, the drug is not distributed in the previous tube. . Therefore, it has been difficult to deliver several tens of microliters of medicine to the discharge part at the tip of the tube.

  In the past, in order to solve such problems related to micro-administration of a drug, the drug was diluted and injected in an increased volume. However, it is not appropriate to dilute the drug in the case of administration of an anticancer drug that requires the drug solution to be delivered at a high concentration.

  For this reason, a method has been proposed in which a chemical solution reservoir is directly carried to an affected area, and the reservoir is pressurized and then released directly (for example, see Patent Document 1). According to this method, the drug solution can be delivered directly to the affected area without reducing the concentration.

Special table 2003-521275 gazette

  However, since the volume of the tumor is large in the portion where the tumor has grown greatly, the method described in Patent Document 1 in which the chemical solution is discharged from the openings of the plurality of tubes by pressurization, some of the tubes When the opening is blocked by a part of the tumor that has grown greatly, there is a problem that the medicine cannot be discharged to the tumor around the opening. Originally, although the drug should be administered to such a tumor part, the method described in Patent Document 1 conversely reduces the dose of the drug, and the necessary drug is accurately determined. Could not be administered in the correct amount.

  This invention is made in view of the above, Comprising: It aims at providing the catheter and chemical | medical agent administration apparatus which can administer a trace amount chemical | medical agent correctly.

  In order to solve the above-described problems and achieve the object, a catheter according to the present invention is a catheter that is punctured into a living tissue of a mammal including a human and administers a medicine, and has a lumen inside. An elongated casing having at least one through-hole that communicates the lumen with the outside, an impermeable elastic sheet that covers the through-hole, and the through-hole from outside the elastic sheet. And a pressure-permeable hard exterior material that can penetrate the surface.

  The catheter according to the present invention is characterized in that, in the above-described invention, the catheter further includes a deformation regulating member that regulates a maximum amount of deformation of the elastic sheet between the lumen and the elastic sheet.

  In the catheter according to the present invention as set forth in the invention described above, the deformation restricting member is a mesh member disposed along the inner wall of the lumen.

  In the catheter according to the present invention as set forth in the invention described above, the deformation restricting member is a lid member that is formed so that fluid can pass therethrough and can be fitted into the through hole.

  The catheter according to the present invention is characterized in that, in the above-mentioned invention, the hard sheath is provided with a valve that closes in a non-pressurized state and opens in a pressurized state.

  The catheter according to the present invention is characterized in that, in the above invention, the hard sheath material is provided with a capillary that does not allow the drug to permeate in a non-pressurized state and allows the drug to permeate in a pressurized state. To do.

  Further, the catheter according to the present invention is characterized in that, in the above invention, the hard sheath material is provided with a slit that does not allow the drug to pass through in a non-pressurized state and allows the drug to pass through in a pressurized state. To do.

  In the catheter according to the present invention, in the above invention, the hard sheath material is made of a porous material that does not allow the drug to permeate in a non-pressurized state and allows the drug to permeate in a pressurized state. Features.

  Further, the catheter according to the present invention is the above-described invention, further comprising a sheath that accommodates at least a part of the catheter therein and is slidable in the axial direction of the catheter, and the sheath includes the through hole. It is slidable to the 1st position which covers all, and the 2nd position which does not cover the said through-hole.

  In the above invention, the catheter according to the present invention further includes a pressing mechanism that presses an elastic sheet covering the through hole outward at a position corresponding to the through hole in the lumen. And

  The catheter according to the present invention is characterized in that, in the above invention, a wall surface surrounding the periphery of the through hole is provided on the outer surface side of the housing.

  According to another aspect of the present invention, there is provided a drug administration device comprising: the catheter described in any one of the above; a pressure-reducing unit that communicates with the lumen of the catheter and causes the pressure in the lumen to transition to a reduced-pressure state or a pressurized state; , Provided.

  According to the present invention, the catheter body is an elongated casing having at least one through-hole that communicates the internal lumen with the outside, the impermeable elastic sheet that covers the through-hole, and the through-hole from the outside of the elastic sheet It is possible to store the drug directly at the distal end of the catheter housing, and to administer the drug directly from the distal end of the catheter housing. Since it can be discharged to the tissue of the target portion, it is possible to accurately administer a minute amount of medicine.

FIG. 1 is a diagram illustrating an example of a configuration of a drug administration device according to an embodiment. FIG. 2 is a view for explaining the catheter shown in FIG. 1. FIG. 3 is a cross-sectional view of the catheter shown in FIG. 2 cut along the axial direction. 4 is an exploded perspective view of the distal end portion of the catheter shown in FIG. FIG. 5 is a diagram for explaining a drug administration process by the drug administration device according to the prior art. FIG. 6 is a cross-sectional view of the distal end portion of the housing of the catheter in each state shown in FIGS. 5 (1) to (3). FIG. 7 is a perspective view showing another example of the catheter in the embodiment. FIG. 8 is a view showing a cross section near the distal end of the catheter in a cross section obtained by cutting the catheter shown in FIG. 7 (2) along the axial direction. FIG. 9 is a perspective view showing another example of the catheter in the embodiment. FIG. 10 is a view showing a cross section near the distal end of the catheter among the cross sections obtained by cutting the catheter shown in FIG. 9 along the axial direction. FIG. 11 is a perspective view showing another example of the catheter in the embodiment. 12 is a diagram illustrating an example of the hard exterior material illustrated in FIG. 3. FIG. 13 is a diagram illustrating an example of the hard exterior material illustrated in FIG. 3. FIG. 14 is a diagram illustrating an example of the hard exterior material illustrated in FIG. 3. FIG. 15 is a diagram illustrating an example of the hard exterior material illustrated in FIG. 3. 16 is a view showing another example of the housing of the catheter shown in FIG. 17 is a view showing another example of the housing of the catheter shown in FIG. 18 is a view showing another example of the housing of the catheter shown in FIG. 19 is a cross-sectional view showing another example of the housing of the catheter shown in FIG. 20 is a cross-sectional view showing another example of the housing of the catheter shown in FIG. FIG. 21 is a cross-sectional view showing another example of the catheter shown in FIG. FIG. 22 is a cross-sectional view illustrating another example of the drug administration device according to the embodiment. FIG. 23 is a cross-sectional view illustrating another example of the drug administration device according to the embodiment. 24 is a cross-sectional view showing another example of the housing of the catheter shown in FIG. 25 is a cross-sectional view showing another example of the housing of the catheter shown in FIG.

  DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, a catheter and a drug administration device that are punctured into a living tissue of a mammal including a human and administer a drug will be described as embodiments for carrying out the present invention with reference to the drawings. Note that the present invention is not limited to the embodiments. In the description of the drawings, the same parts are denoted by the same reference numerals.

  FIG. 1 is a diagram illustrating an example of a configuration of a drug administration device according to the present embodiment. As shown in FIG. 1, the drug administration device 1 in the present embodiment has a catheter 3, and the proximal end portion of the catheter 3 is connected to a syringe 2. The distal end portion of the catheter 3 is punctured into an organ 7 which is a body tissue. A drug administration unit 4 is provided in the vicinity of the distal end of the catheter 3. The catheter 3 is punctured into the organ 7 so that the drug administration unit 4 is located in the drug administration target unit 7a such as a tumor during drug administration. The syringe 2 includes a cylinder 2a and a plunger 2b that reciprocates in the cylinder 2a and pumps a fluid such as gas. The syringe 2 communicates with the lumen in the catheter 3 and functions as a pressurization / decompression unit that changes the pressure in the lumen to a pressurized state or a depressurized state.

  FIG. 2 is a view for explaining the catheter 3 shown in FIG. The catheter 3 is constituted by a tubular elongated casing 8 formed of a biocompatible flexible material (for example, silicon, polytetrafluoroethylene, polyvinyl chloride, polyethylene) and having a lumen 9 therein. The tip 5 of the housing 8 has a pointed shape for puncturing into the body. An opening 6 is also provided at the base end of the housing 8, and the opening 6 at the base end communicates with the cylinder 2 a of the syringe 2.

  The syringe 2 shown in FIG. 1 communicates with the lumen 9 in the catheter 3, and when the plunger 2b of the syringe 2 advances toward the catheter 3, the fluid is pumped to the lumen 9 of the catheter 3, and the pressure of the lumen 9 is increased. Let the state be a pressurized state. Moreover, the syringe 2 attracts | sucks the fluid in the lumen | rumen 9 when the plunger 2b of the syringe 2 retreats from the catheter 3, and makes the pressure state of the lumen | rumen 9 into a pressure-reduced state. Although FIG. 1 shows the case where the syringe 2 is used as the pressurizing and depressurizing unit, the present invention is not limited to this, and a pump or a compressor may be used instead of the syringe 2.

  A drug administration unit 4 is provided in the vicinity of the tip of the housing 8. The drug administration unit 4 stores a drug to be administered to the tumor 7a that is a drug administration target and has a function of discharging the stored drug to the tissue of the tumor 7a. First, the structure of the drug administration unit 4 will be described. 3 is a cross-sectional view taken along the axial direction of the catheter 3, and FIG. 4 is an exploded perspective view of the distal end portion of the catheter 3 for explaining the configuration of the drug administration unit 4.

  As shown in FIGS. 3 and 4, the drug administration unit 4 is provided with a through hole 10 that communicates with the lumen 9. The through hole 10 is covered with an impermeable elastic sheet 11. And the sheet-like hard exterior material 12 which has pressurization permeability has covered the through-hole 10 from the outer side rather than this elastic sheet 11. FIG. The elastic sheet 11 is bonded to the casing 8 over the entire periphery of the end portion, and the hard exterior material 12 is bonded to the casing 8 or the elastic sheet 11 over the entire periphery of the end portion. Further, the elastic sheet 11 and the hard exterior material 12 are in a state where the surfaces do not adhere at least in a region located on the through hole 10.

  The elastic sheet 11 is formed of an impermeable material that does not allow fluid such as a drug to pass through. Moreover, the elastic sheet 11 is provided with the elasticity which deform | transforms with the pressure difference of both surfaces. The elasticity of the elastic sheet is sufficient to allow the elastic sheet 11 to deform due to pressure fluctuations in the lumen 9 caused by the syringe 2. The elastic sheet 11 is made of, for example, silicon or natural rubber.

  The hard exterior material 12 does not substantially deform due to a pressure difference between both surfaces, or has at least a hardness that is less deformed than the elastic sheet 11. Specifically, the hard sheathing material 12 has such a hardness that the hard sheathing material does not substantially change its outer shape due to pressure fluctuation in the lumen 9 caused by the syringe 2. The hard exterior material 12 has pressure permeability and does not allow fluid such as a drug to pass through in a non-pressurized state where the pressure difference between the exterior sides is smaller than a predetermined value, but the pressure difference between the exterior sides exceeds a predetermined value. In a pressurized state, a fluid such as a medicine is allowed to permeate. The hard exterior material 12 is made of, for example, silicon, PTFE, ePTFE (stretched porous PTFE), polyvinyl chloride, polyethylene, polystyrene, natural rubber, or the like.

  Next, the storage of the medicine in the medicine administration apparatus 1 shown in FIG. 1 and the administration of the stored medicine to the living tissue will be described. FIG. 5 is a view for explaining storage of the medicine and administration of the medicine in the medicine administration device, and FIG. 6 shows a distal end portion of the housing 8 of the catheter 3 in each state shown in FIGS. 5 (1) to (3). It is sectional drawing which cut | disconnected along the axial direction.

  The case where a medicine is stored in the medicine administration part 4 at the tip of the housing 8 constituting the catheter 3 will be described. First, as shown in FIG. 5 (1), the drug administration part 4 at the tip of the housing 8 constituting the catheter 3 is immersed in the drug L in the container B. In a state where the plunger 2b of the syringe 2 is not advanced or retracted, as shown in FIG. 6 (1), the lumen 9 is in a non-pressurized state, the elastic sheet 11 is not deformed, and the drug administration unit 4 is not loaded with a drug. Not yet contained.

  Next, as indicated by an arrow Y1 in FIG. 5B, the plunger 2b of the syringe 2 is pulled out and retracted. As a result, as shown in FIG. 6 (2), the lumen 9 is in a reduced pressure state in which pressure in the direction of the arrow Y1a is generated. Due to the pressure in the arrow Y1a direction, the elastic sheet 11 is pulled into the lumen 9 and the elastic sheet 11 bulges into the lumen 9 through the through hole 10. Furthermore, the pressure in the arrow Y1a direction is also applied to the hard exterior material 12 outside the elastic sheet 11. By applying the pressure in the direction of the arrow Y1a, the medicine can pass through the hard exterior material 12 in the direction of the arrow Y1b, and the medicine L outside the housing 8 permeates the hard exterior material 12 to In between the elastic sheet 11 inflated in the lumen 9 and is held.

  Accordingly, in the drug administration device 1, the plunger 2b of the syringe 2 is retracted while the drug administration unit 4 is immersed in the drug L as indicated by the arrow Y1 in FIG. The medicine L can be stored between the hard exterior material 12 and the elastic sheet 11 expanded in the lumen 9.

  Next, a case where a medicine stored in the medicine administration unit 4 is administered to the tumor 7a will be described. After the entire catheter 3 is removed from the container and the drug attached to the periphery of the catheter 3 is wiped, the catheter 3 remains in the organ until the drug administration part 4 at the distal end of the housing 8 of the catheter 3 reaches the drug administration target part 7a such as a tumor. 7 is punctured. Thereafter, as shown in FIG. 5 (3), the plunger 2b of the syringe 2 is pushed in and advanced. As a result, as shown in FIG. 6 (3), the lumen 9 is in a pressurized state in which pressure in the direction of the arrow Y2a is generated. Due to the pressure in the direction of the arrow Y2a, the elastic sheet 11 is pushed upward through the through hole 10 as indicated by the arrow Y2b. Further, since the pressure in the direction of the arrow Y2b is also applied to the hard exterior material 12 outside the elastic sheet 11, the medicine L can pass through the hard exterior material 12 in the direction of the arrow Y2c, and between the elastic sheet 11 and the hard exterior 12 The stored medicine L passes through the hard sheath 12 and is discharged and administered to the tumor 7a. Here, by adjusting the inner diameter of the through hole 10 and the elasticity of the elastic sheet 11, the volume of the medicine stored by the medicine administration unit 4 can be controlled. The drug administration unit 4 can accommodate a small amount of drug of, for example, several tens of μl according to the absorption rate of the chemical solution of a living tissue such as an organ by adjusting the inner diameter of the through hole 10 and the elasticity of the elastic sheet 11. is there.

  Therefore, in the drug administration device 1, as shown by the arrow Y2 in FIG. 5 (3), by puncturing the distal end of the housing 8 of the catheter 3 to the drug administration target portion 7a, the plunger 2b of the syringe 2 is advanced, A small amount of drug L stored in the drug administration unit 4 can be administered to the drug administration target unit 7a.

  Thus, in the embodiment, by reciprocating the plunger 2b of the syringe 2, a small amount of drug is stored in advance in the drug administration part 4 at the tip of the housing 8 that is punctured to the drug administration target part 7a. After puncturing the housing 8 of the catheter 3 up to the drug administration target part 7a, a trace amount of drug is directly discharged from the drug administration part 4 at the tip to the drug administration target part 7a. Therefore, in the embodiment, a predetermined minute amount of drug can be accurately administered to the drug administration target portion 7a without changing the drug into the entire lumen 9 of the housing 8 while maintaining a desired concentration. Then, since the drug administration unit 4 at the distal end of the catheter 3 is punctured to the drug administration target unit 7a and then the drug is ejected from the drug administration unit 4, the drug administration target unit 7a is at a deep position from the body surface. Even in this case, a minute amount of drug can be administered accurately. Further, in the present embodiment, since the medicine is discharged to the outside of the housing 8 so as to ooze out from the pressure-permeable hard exterior material 12 by being in a pressurized state, the medicine administration unit 4 comes into contact with a tumor or the like. Even if it is, the ejection of the medicine is not hindered by the tumor, and the medicine can be supplied in an accurate amount to the medicine administration target portion 7a.

  As described below, in the embodiment, by adding a deformation restricting member capable of restricting the maximum amount of deformation of the elastic sheet 11, the maximum amount of deformation of the elastic sheet 11 is restricted, and the inside of the drug administration unit 4 is controlled. It may be possible to define the maximum capacity of the medicine stored in the container.

  FIG. 7 is a perspective view showing another example of the catheter in the embodiment, and FIG. 8 is a view showing a cross section in the vicinity of the distal end of the catheter in a cross section obtained by cutting the catheter of FIG. 7 (2) along the axial direction. It is. As this deformation regulating member, a cylindrical mesh member 13 is inserted into the lumen 9 of the housing 8 as shown in FIG. As a result, the mesh member 13 is disposed along the inner wall of the lumen 9. In the vicinity of the tip of the housing 8, the drug administration part 4 is formed in which the through-hole 10 is covered with the elastic sheet 11 and the hard sheathing material 12, so that the mesh member 13 is shown in FIGS. 7 (2) and 8. As shown in FIG. 2, the lens is disposed between the lumen 9 and the elastic sheet 11. As shown in FIG. 8, in the catheter 3a in which the mesh member 13 is provided in the lumen, the elastic sheet 11 is pulled inside the lumen 9 by the pressure in the direction of the arrow Y1a generated by the retraction of the plunger 2b of the syringe 2. The deformation is restricted by the mesh member 13 and can be deformed only up to the position where the mesh member 13 is disposed. For this reason, the medicine L that has permeated through the hard exterior member 12 as indicated by the arrow Y1b is stored in a capacity V1 corresponding to the maximum amount of deformation of the elastic sheet 11. Thus, since the maximum amount of deformation of the elastic sheet 11 is regulated by the mesh member 13, the capacity of the medicine L can be stored with high accuracy without variation.

  Further, as the deformation regulating member, a lid member 14 that can be fitted into the through hole 10 shown in FIGS. 9 and 10 may be used in place of the cylindrical mesh member 13. FIG. 9 is a perspective view showing another example of the catheter in the embodiment, and FIG. 10 is a view showing a cross section in the vicinity of the distal end of the catheter in a cross section obtained by cutting the catheter of FIG. 9 along the axial direction. Since this lid member 14 is formed in a lid shape by, for example, a wire, it can permeate a fluid medicine, but inhibits permeation of the individual. As shown in FIG. 9, the drug administration unit 4 is formed by covering the through hole 10 with the elastic sheet 11 and the hard exterior material 12 in a state where the lid member 14 is fitted in the through hole 10. . Accordingly, the lid member 14 is disposed between the lumen 9 and the elastic sheet 11 as shown in FIG. For this reason, in the catheter 3b provided with the lid-like member 14, even if the elastic sheet 11 is pulled into the lumen 9 by the pressure in the direction of the arrow Y1a generated by the retraction of the plunger 2b of the syringe 2, the lid-like member 14 Therefore, the deformation is restricted, and the deformation can be made only up to the position where the mesh member 13 is disposed. As a result, the medicine L that has permeated through the hard exterior member 12 as indicated by the arrow Y1b is stored in a capacity V2 corresponding to the maximum amount of deformation of the elastic sheet 11. Also in this case, since the maximum amount of deformation of the elastic sheet 11 is regulated by the lid-like member 14, the capacity of the medicine L can be stored accurately without variation.

  In addition, as shown in FIG. 11, at least a part of the catheter 3 may be accommodated therein, and a sheath 15 that is slidable in the axial direction of the catheter 3 may be further provided. The sheath 15 has a first position (see FIG. 11 (1)) that covers at least all of the through holes 10 of the drug administration unit 4 and a first position that does not cover the through holes of the drug administration unit 4 as indicated by an arrow Y3. It is slidable in the axial direction of the catheter 3 at a position 2 (see FIG. 11B). After the medicine is stored in the medicine administration section 4, the sheath 15 is slid so as to cover the through hole of the medicine administration section 4, so that the medicine is inadvertently discharged from the medicine administration section 4, and the medicine adheres to an unintended site. This can be prevented. When the distal end of the catheter 3 is punctured to the drug administration target portion 7a, the sheath 15 is slid in the proximal direction of the catheter 3 as indicated by the arrow Y3 in FIG. 11 (2), and the drug administration portion 4 is exposed. A puncture may be performed.

  Moreover, as shown in FIG. 12, a sheet member 12a provided with a valve 121 that closes in a non-pressurized state and opens in a pressurized state can be used as the hard exterior member 12. Moreover, as the hard exterior material 12, as shown in FIG. 13, a sheet member 12b provided with a capillary that does not allow the drug to pass through in the non-pressurized state and allows the drug to pass through in the pressurized state can be used. Moreover, as the hard exterior material 12, as shown in FIG. 14, a sheet member 12c provided with a slit 123 that does not transmit the drug in the non-pressurized state and transmits the drug in the pressurized state can be used. Further, as shown in FIG. 15, a sheet member formed of a porous material having a plurality of fine holes 124 that do not allow the drug to pass through in the non-pressurized state but allow the drug to pass through in the pressurized state, as the hard exterior material 12. 12d can be used.

  Moreover, the through-hole 10 which comprises the chemical | medical agent administration part 4 is not restricted circularly, A rectangle may be sufficient like the through-hole 10a provided in the housing 8a of FIG. 16 (1). Moreover, you may provide the several through-hole 10 like the housing 8b shown to FIG. 16 (2). Furthermore, as shown in FIG. 17, a plate-like housing 8 c may be used as the catheter body, and a plurality of through holes 10 may be provided. Moreover, you may provide the through-holes 10, 10a, 10b which have various shapes, such as circular and a rectangle, like the housing 8d shown in FIG. The shape of the through hole and the number of through holes may be selected according to the dose of the drug. Then, as shown in FIG. 18, all of these through holes 10, 10 a, 10 b may be covered with one elastic sheet 11 and hard exterior material 12, and a plurality of elastic members are provided for each predetermined number of through holes 10. You may cover with the sheet | seat 11 and the hard exterior material 12. FIG.

  Further, as shown in the case 8e of FIG. 19, when a plurality of through holes 101 to 103 are provided in the same lumen 9e, by moving the plunger 2b of the single syringe 2 communicating with the lumen 9e forward and backward, As shown by the arrow Y3, the medicines can be stored and discharged through the through holes 101 to 103 in a lump, and the medicine administration process of the catheter user can be facilitated. Of course, as shown in the housing 8f of FIG. 20, the flow paths may be divided by the two through holes 101a and the through holes 102a, respectively. In this case, two lumens 91f and 92f and syringes 21 and 22 communicating with the lumens 91f and 92f are provided so as to correspond to the through holes 101a and 102a, respectively. By moving a plunger (not shown) accommodated in the syringe 21 forward and backward, as shown by an arrow Y3a, the medicine is stored in the medicine administration unit 41 constituted by the through hole 101a, the elastic sheet 111, and the hard exterior material 121, and the medicine Discharging can be performed. Further, by moving a plunger (not shown) accommodated in the syringe 22 forward and backward, the medicine is stored and discharged into the medicine administration section 42 constituted by the through hole 102a, the elastic sheet 112 and the hard exterior material 122. This can be performed separately from the administration unit 41. As described above, the medicine storing process and the medicine administration process may be performed for each of the through holes 101a and 102a by dividing the flow path for each of the through holes 101a and 102a. Further, by changing the inner diameters of the through holes 101a and 102a, the medicine administration section 41 and the medicine administration section 42 may store and administer different volumes of medicine.

  Of course, the fluid filling the lumen 9 is not limited to gas but may be liquid. In this case, as shown in FIG. 21, the inside of the lumen 9 is filled with the liquid W, and this liquid is pumped to the drug administration unit 4 as indicated by the arrow Y5a by the reciprocation of the plunger 2b in the cylinder 2, and then to the drug administration unit 4. The medicine is stored and the medicine L is administered from the medicine administration unit 4 to the outside.

  Moreover, a pressing mechanism that presses the elastic sheet 11 covering the through hole 10 toward the outside may be further provided to administer the medicine from the medicine administration unit 4 to the outside. For example, as shown in FIG. 22, the elastic sheet 11 is pressed outward using a balloon member 16 having a balloon 16a connected to the tube 16b. In this case, after the balloon member 16 is inserted until the balloon 16a reaches a position corresponding to the arrangement position of the through hole 10, the balloon 16a is inflated by injecting fluid from the tube 16b as indicated by an arrow Y4. Then, as shown by the arrow Y5b, the elastic sheet 11 is pushed out of the housing 8 and the drug is administered from the drug administration unit 4. Further, as shown in FIG. 23, the elastic sheet 11 may be pushed out of the housing 8 using a jack member 17. In this case, the jack member 17 is inserted into the internal lumen 9. Then, after the distal end extruding members 17a and 17b are inserted to the positions corresponding to the positions where the through holes 10 are disposed, the base end members 17c and 17d are operated as indicated by the arrow Y4c to move the distal end extruding members 17a and 17b. By pushing and spreading as indicated by the arrow Y5c, the elastic sheet 11 is pushed out of the housing 8 as indicated by the arrow Y5d and the drug is administered from the drug administration unit 4.

  Further, as shown in a housing 8g in FIG. 24, a recess 81g may be provided on the outer surface side of the housing 8g, and the through hole 10 may be provided at the bottom of the recess 81g. In this case, the wall surface 10g forming the recess 81g surrounds the periphery of the through hole 10. For this reason, the medicine administration part 4g formed by the through hole 10, the elastic sheet 11, and the hard exterior material 12 is located at the bottom part of the concave part 81g of the housing 8g, and is directly with the tissue of the medicine administration target part 7a. Do not touch. In other words, the tissue of the drug administration target unit 7 a does not block the drug administration unit 4. For this reason, the medicine L discharged to the outside of the housing 8g from the medicine administration part 4g is gradually absorbed by the tissue of the medicine administration target part 7a in a state where it is once accumulated in the region S1 in the recess 81g. Therefore, the concave portion 81g functions as a buffer region for storing medicine to be discharged to the outside.

  As described above, when the drug L is administered to the tissue of the drug administration target unit 7a through the buffer region, the drug L stored in the drug administration unit 4g is simply applied with a pressure sufficient to be discharged into the buffer region. Good. As shown in FIG. 6, when the drug administration unit 4 is in direct contact with the tissue of the drug administration target unit 7a, the drug is stained between the tissue of the drug administration target unit 7a in contact with the drug administration unit 4. It is necessary to apply pressure from the inside of the housing to the extent that a gap can be created. On the other hand, when a buffer area is provided as shown in FIG. 24, it is sufficient if the medicine can be discharged into this buffer area, and a gap needs to be created between the tissue of the medicine administration target section 7a and the medicine administration section. Therefore, the pressure from the inside of the housing applied for drug administration can be reduced, and the drug administration process can be facilitated. Moreover, since the recessed part 81g formed with the wall surface 10g is formed so that a cross-sectional shape may expand toward the upper part from the through-hole 10 side of a bottom part, a chemical | medical agent etc. can be spread widely with respect to a structure | tissue.

  Of course, as shown in FIG. 25, a ring-shaped wall surface 10h formed so as to protrude is provided on the outer surface side of the housing 8h, and the buffer region S2 is provided between the drug administration unit 4h and the tissue of the drug administration target unit 7a. May be formed. Further, a buffer member may be formed by attaching a sheet member having a wall surface 10g or a wall surface 10h so as to surround the drug administration unit 4 to a position corresponding to the drug administration unit 4.

DESCRIPTION OF SYMBOLS 1 Drug administration device 2,21,22 Syringe 2a Cylinder 2b Plunger 3 Catheter 4,4g, 4h, 41,42 Drug administration part 6 Opening part 7 Organ 7a Drug administration target part 8,8a, 8b, 8c, 8d, 8e , 8f, 8g, 8h Housing 9, 9e, 91f, 92f Lumen 10, 10a, 10b, 101-103 Through hole 10g, 10h Wall surface 11, 111, 112 Elastic sheet 12, 121, 122 Rigid exterior material 13 Net member 14 Lid Member 15 Sheath 16 Balloon member 17 Jack member

Claims (12)

A catheter that is punctured into a living tissue of a mammal including a human and administers a drug,
An elongated casing having a lumen inside and having at least one through hole communicating the lumen with the outside;
An impermeable elastic sheet covering the through hole;
Covering the through-hole from the outside of the elastic sheet, a pressure-permeable hard exterior material that allows the drug to pass through in a pressurized state;
A catheter comprising:   The catheter according to claim 1, further comprising a deformation restricting member that restricts a maximum amount of deformation of the elastic sheet between the lumen and the elastic sheet.   The catheter according to claim 2, wherein the deformation regulating member is a mesh member disposed along the inner wall of the lumen.   The catheter according to claim 2, wherein the deformation regulating member is a lid member that is formed so as to allow fluid to pass therethrough and can be fitted into the through hole.   The catheter according to claim 1, wherein the hard sheath is provided with a valve that closes in a non-pressurized state and opens in a pressurized state.   The catheter according to claim 1, wherein the hard sheath material is provided with a capillary that does not allow the drug to pass through in a non-pressurized state and allows the drug to pass through in a pressurized state.   The catheter according to claim 1, wherein the hard sheath material is provided with a slit that does not allow the drug to pass through in a non-pressurized state and allows the drug to pass through in a pressurized state.   2. The catheter according to claim 1, wherein the hard sheath material is made of a porous material that does not transmit a drug in a non-pressurized state and transmits a drug in a pressurized state. A sheath that accommodates at least a portion of the catheter therein and is slidable in the axial direction of the catheter;
The catheter according to claim 1, wherein the sheath is slidable between a first position that covers all the through holes and a second position that does not cover the through holes.   The catheter according to claim 1, further comprising a pressing mechanism that presses an elastic sheet covering the through hole outward at a position corresponding to the through hole in the lumen.   The catheter according to claim 1, wherein a wall surface surrounding the through hole is provided on the outer surface side of the housing. A catheter according to any one of claims 1 to 11;
A pressure-reducing unit that communicates with the lumen of the catheter and changes the pressure in the lumen to a reduced-pressure state or a pressurized state;
A drug administration device comprising:

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