KR20190045073A - Dietary herbal composition for improving obesity and method for producing the same - Google Patents
Dietary herbal composition for improving obesity and method for producing the same Download PDFInfo
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Abstract
Description
본 발명은 항비만 활성을 갖는 한방 조성물 및 그 제조방법에 관한 것으로, 보다 상세하게는 독성 없이 비만을 치료할 수 있는 한방 약재 추출물을 유효성분으로 함유하는 항비만 활성을 갖는 한방 조성물 및 그 제조방법에 관한 것이다.The present invention relates to a herbal composition having anti-obesity activity and a preparation method thereof, and more particularly, to a herbal composition having an anti-obesity activity containing an herbal medicine extract which can treat obesity without toxicity as an active ingredient, .
현대인이 접하는 식생활 문화는 생활환경의 향상과 편리함을 추구하는 인스턴트식품의 증가, 식생활의 서구화로 단순당, 육류, 지방 등의 섭취가 급격하게 증가하고 있을 뿐만 아니라, 바쁜 사회생활에서 받는 스트레스와 운동 부족, 음식의 과다섭취 등의 원인으로 비만 환자가 날로 증가하고 있다. 이로 인해 각종 만성성인질환의 유병율이 증가하고 있으며, 이러한 질병들은 역학적 연구들을 종합하여 볼 때 비만과 매우 밀접한 관련이 있는 것으로 나타났다. 더욱이 최근 들어 사회적으로나 경제적으로 그 심각성이 대두되고 있는 성인병의 예방 및 치료를 위하여 비만을 개선 또는 치유할 수 있는 획기적인 방법의 제안이 요구되고 있는 설정이다.The dietary culture encountered by modern people is not only increased in consumption of simple sugars, meat, and fats due to the improvement of the living environment, the increase of instant food seeking convenience, and the westernization of eating habits, but also the stress and exercise Obesity is increasing day by day due to lack of food, excessive intake of food, etc. The prevalence of various chronic adult diseases is increasing, and these diseases are closely related to obesity based on epidemiological studies. In addition, recently, a proposal for a novel method for improving or curing obesity for the prevention and treatment of adult diseases, whose seriousness is increasingly socially and economically, is required.
최근 이러한 사회 현상에 부응하고, 비만에 대한 심각성 인식으로 다이어트에 대한 관심이 점점 높아지고 있으며, 이에 수많은 다이어트 관련 제품, 관리센터 등이 생겨났고 현재도 많은 다이어트 제품들이 생산 및 판매되고 있는 상황이다. 한국은 물론 일본, 중국 등 많은 나라에서 수많은 다이어트 제품이 개발되고 생산되어 제품화되고 있다. Recently, in response to these social phenomena and awareness of the seriousness of obesity, interest in diet has been increasing, and there have been many dietary products and management centers, and many dietary products are being produced and sold. Numerous diet products are being developed, produced and commercialized in many countries including Korea, Japan, and China.
그러나, 다이어트 제품들 중 대다수는 단일성분으로 구성된 제품들이 많으며, 사람의 신체의 신진대사와는 무관한 단일 효과만을 갖는 제품들이 시판되고 있는 실정이다. 이러한 제품들의 경우, 단기적인 효과를 볼 수 있을지 모르지만, 장기적인 섭취 시 위장질환, 역류성 식도염, 두통과 같은 일반적인 부작용뿐만 아니라, 여성의 월경불순과 생리통이 수반되는 부작용이 심각하며 요요현상까지 발생하여 장기적으로 그 효과가 미미하다는 문제점이 있었다. However, many of the diet products are composed of a single component, and products having only a single effect that is not related to the metabolism of the human body are commercially available. These products may have a short-term effect, but long-term ingestion can lead to general side effects such as gastrointestinal disease, reflux esophagitis and headache, as well as serious adverse effects associated with menstrual irregularities and menstrual cramps, There is a problem that the effect is insignificant.
또한, 체중감량을 위해 일반의약품까지도 일반인들이 관심을 보이고 섭취하고 있는 실정인데, 대표적인 다이어트 의약품으로는 식욕억제제가 있으며, 이와 같은 식욕억제제는 지속적인 효과보다는 오히려 불면증, 환각증세, 현기증, 두통 등의 부작용을 초래하는 경우가 많다. 따라서 체중감량을 위하여 안전하고 과학적이며, 영양 생리학적으로 부작용이 없고 요요현상이 없는 다이어트 식품 및 방법이 요구되고 있다.In addition, general weight loss medicines are being watched by the general public. Typical diet medicines include appetite suppressants. These appetite suppressants are more effective than side effects such as insomnia, hallucinations, dizziness, headache In many cases. Therefore, there is a need for diet foods and methods that are safe, scientific, nutritionally physiologically free of side effects for weight loss, and free of yo-yo phenomena.
따라서, 상기한 현상을 인지하고 이를 해결하기 위해 종래에도 많은 방안이 제안되어 왔는데, 예를 들어 대한민국 특허공개번호 제2003-0005086호(특허문헌 1)에서는 생식 및 식이섬유를 함유하는 다이어트 조성물이라는 명칭으로, 곡물류, 채소류, 해조류 등의 동결건조 분말로 이루어진 생식과 식이섬유 및 기능성 허브추출물 등을 함유한 다이어트 조성물을 개시하고 있으며, 대한민국 특허출원번호 제2005-0093577호(특허문헌 2)에서는 비만 억제용 조성물이라는 명칭으로, 멜리사엽 추출물, 인진쑥 추출물, 뽕나무잎 추출물을 유효성분으로 하는 비만 억제용 조성물에 대해 개시하고 있으며, 대한민국 특허출원번호 제2007-0010661호(특허문헌 3)에서는 비만 예방 및 억제능 갖는 한약재 추출 조성물이라는 명칭으로, 송엽, 상엽, 자작엽, 목과, 및 금은화(Lonicera Japonica Thumb)의 추출물을 유효성분으로 함유하는 비만의 예방 및 치료용 조성물에 대해 개시하고 있다.For example, Korean Patent Laid-Open No. 2003-0005086 (Patent Document 1) discloses a diet composition containing a reproductive and dietary fiber, Discloses a diet composition containing reproductive and dietary fiber and functional herbal extracts composed of lyophilized powders such as grains, vegetables, seaweeds, etc. Korean Patent Application No. 2005-0093577 (Patent Document 2) A composition for preventing obesity, which comprises Melissa leaf extract, Artemisia officinalis extract and Mulberry leaf extract as active ingredients, and Korean Patent Application No. 2007-0010661 (Patent Document 3) discloses a composition for preventing and inhibiting obesity The composition of the herbal medicinal herb extract has the following characteristics: aponica Thumb) as an active ingredient for preventing and treating obesity.
또한, 대한민국 특허공개번호 제2014-0022648호(특허문헌 4)에서는 구기자잎 추출 분말과 베타인을 유효성분으로 함유하는 항비만 조성물이라는 명칭으로, 베타인과 구기엽 추출물 성분을 인체 및 마우스에 투여하여 체중, 체지방, 총 콜레스테롤, 중성지방, LDL 감소 효과를 평가하여 베타인 화합물, 구기엽 추출물 분말 또는 상기 베타인과 구기엽 추출물 분말의 혼합물을 비만 또는 비만 유래 대사증후군 예방 및 치료용 의약품 소재 또는 비만 개선용 건강기능성식품 소재로 제공하는 것을 개시하고 있으며, 대한민국 특허공개번호 제2015-0051020호(특허문헌 5)에서는 비만억제 및 다이어트 조성물이라는 명칭으로, "차전자피 추출물, 잎새버섯 추출물 및 의이인 추출물을 포함하는 한방재인 제1 성분; 식이섬유, 전분 및 아미노산을 포함하는 제2 성분; 및 비타민을 포함하는 제3 성분;을 유효성분으로 함유하고, 상기 제1 성분은, 비만억제 및 다이어트 조성물 전체 100중량%에 대하여, 차전자피 추출물 10 내지 40중량%, 잎새버섯 추출물 1 내지 4중량%, 이의인 추출물 8 내지 32중량%, 다시마 추출물 10 내지 40중량%, 양파 추출물 8 내지 32중량%, 길경(도라지) 추출물 8 내지 32중량%, 숙지황 추출물 8 내지 32중량%, 천궁 추출물 5 내지 20중량%, 녹각 추출물 0.01 내지 0.05중량%, 당귀 추출물 0.1 내지 0.5중량%, 감초 추출물 0.1 내지 0.5중량% 및 율무 분말 1 내지 4중량%를 포함하고, 상기 제2 성분은, 비만억제 및 다이어트 조성물 전체 100중량%에 대하여, 식이섬유로, 폴리덱스트로스 0.5 내지 5중량% 및 솔비톨 1 내지 10중량%를 포함하고, 전분으로, 이소말토 올리고당 1 내지 10중량% 및 덱스트린 0.5 내지 1중량%를 포함하고, 아미노산으로, 타우린 0.05 내지 0.5중량% 및 글리신 0.015 내지 0.15중량%를 포함하고, 상기 제3 성분은, 비만억제 및 다이어트 조성물 전체 100중량%에 대하여, 비타민 B1 0.005 내지 0.05중량%, 비타민 B2 0.001 내지 0.01중량%, 비타민 B6 0.005 내지 0.05중량%, 비타민 B12 0.005 내지 0.05중량%, 비타민 C 0.05 내지 0.5중량% 및 니코틴산아미드 0.015 내지 0.15중량%를 포함하는, 비만억제 및 다이어트 조성물"을 개시하고 있다.Korean Patent Laid-Open Publication No. 2014-0022648 (Patent Document 4) discloses an anti-obesity composition containing Gugija leaf extract powder and betaine as an active ingredient, wherein betaine and a leaf extract component are administered to human and mouse, , Beta-linolenic acid compound, a mixture of a leaf extract of a leaf of a tree or a mixture of the betaine and a leaf extract of a leaf extract to evaluate the effect of decreasing body fat, total cholesterol, triglyceride and LDL Korean Patent Laid-Open Publication No. 2015-0051020 (Patent Document 5) discloses a composition for preventing obesity and a composition for dieting, which comprises a combination of an extract of Bacillus subtilis, A second component comprising dietary fiber, starch and an amino acid; Wherein the first component is selected from the group consisting of 10 to 40% by weight of the extract of Bacillus subtilis extract, 1 to 4% by weight of the extract of Leucocephalus extract, 8 to 32% by weight of an extract thereof, 10 to 40% by weight of seaweed extract, 8 to 32% by weight of an onion extract, 8 to 32% by weight of a Gakgye extract, 8 to 32% Wherein the second component is selected from the group consisting of 100 to 100% of the obesity-suppressing and diet composition, 0.01 to 0.05 wt% of the extract of Guava extract, 0.1 to 0.5 wt% of Angelica gigantosa extract, 0.1 to 0.5 wt% of licorice extract and 1 to 4 wt% Wherein the starch comprises from 1 to 10% by weight of isomaltooligosaccharide and from 0.5 to 1% by weight of dextrin, wherein the starch comprises from 0.5 to 5% by weight of polydextrose and from 1 to 10% by weight of sorbitol as a dietary fiber, 0.05 to 0.5% by weight of taurine and 0.015 to 0.15% by weight of glycine, wherein the third component comprises 0.005 to 0.05% by weight of vitamin B1, 0.001 to 0.01% by weight of vitamin B2, Of vitamin B6, 0.005 to 0.05% by weight of vitamin B6, 0.005 to 0.05% by weight of vitamin B12, 0.05 to 0.5% by weight of vitamin C and 0.015 to 0.15% by weight of nicotinic acid amide.
그런데, 상기한 특허문헌들에 개시된 발명들은 특정한 기능성을 갖는 천연재료를 적의 선정하여 단순히 혼합하여 다이어트 효과를 제공하는 기능성 조성물을 제공하는 것으로, 각 성분들이 비만 개선에 시너지 효과를 발휘할 수 있도록 하는 것에 대해서는 제시된 바 없으며, 또한 기능성을 증진하기 위해 인체에 효과적으로 흡수될 수 있도록 하는 방안과 섭취에 따른 부작용의 억제 또는 해소에 대해서는 개시하고 있지 못하다.However, the inventions disclosed in the above-mentioned patent documents provide a functional composition in which natural ingredients having specific functionalities are merely selected and merely mixed to provide a diet effect. In order to enable each component to exert a synergistic effect on obesity improvement And there is no disclosure of measures to be effectively absorbed by the human body in order to improve the functionality and suppression or elimination of side effects due to ingestion.
이에, 본 발명자들은 섭취에 따른 부작용이 없으면서 비만 개선에 시너지 효과를 발휘할 수 있는 항비만 활성을 갖는 한방 조성물을 확인하고, 본 발명을 완성하기에 이르렀다.Accordingly, the inventors of the present invention have found a herbal composition having anti-obesity activity that can exert a synergistic effect on obesity improvement without side effects due to ingestion, and have completed the present invention.
상기 전술한 종래 문제점을 해결하기 위하여, 본 발명의 목적은 항비만 활성을 갖는 한방 조성물 및 그 제조방법을 제공하는데 있다. 더 상세하게 본 발명은 비만치료에 효과적인 13가지 약재 추출물의 최적의 배합비율을 제공하고자 한다. In order to solve the above-mentioned conventional problems, it is an object of the present invention to provide a herbal composition having anti-obesity activity and a method for producing the same. More specifically, the present invention aims to provide an optimal blend ratio of the 13 herbal extracts effective for the treatment of obesity.
상기 목적을 달성하기 위하여, 본 발명은 피의이인 40~65중량%, 숙지향 8~10중량%, 산약 5~8중량%, 용안육 5~8중량%, 황기 5~8중량%, 구기자 2~5중량%, 상백피 2~5중량%, 택사2~5중량%, 당귀 2~5중량%, 사인 2~5중량%, 천궁 1~2중량%, 감초 1~2중량% 및 행인 1~2중량%로 구성되는 항비만 활성을 갖는 한방 조성물을 제공한다. In order to attain the above object, the present invention provides a method for preparing a starch composition comprising 40 to 65% by weight of bloody, 8 to 10% by weight of ambrosia, 5 to 8% by weight of liquorice, 5 to 8% 2 to 5% by weight of Cucumber, 2 to 5% by weight of Cucumber, 2 to 5% by weight of Cucumber, 2 to 5% by weight of Cucumber, 2 to 5% % ≪ / RTI > by weight of an anti-obesity activity.
본 발명은 또한, (a) 피의이인, 숙지향, 산약, 용안육, 황기, 구기자, 상백피, 택사, 당귀, 사인, 천궁, 감초, 행인의 각 재료를 물로 세척하여 준비하는 단계; (b) 상기 각 재료를 제1항의 중량비로 혼합하는 단계; (c) 상기 혼합한 재료를 가열용기에 넣고, 용매를 첨가하여 110 내지 120℃에서 3 내지 5시간 동안 제1 추출하는 단계 및 (d) 상기 얻은 추출물을 환류 추출로 제2 추출하는 단계를 포함하는, 항비만 활성을 갖는 한방 조성물의 제조방법을 제공한다. The present invention also provides a method for preparing a food or beverage comprising the steps of: (a) preparing each of the ingredients of Blood, Ambipolar, Acanthopanax, Radix, Radix, Radix, Phytophthora, Phytophthora, Angelica, Codonopsis, Licorice, Licorice; (b) mixing the respective materials in the weight ratio of claim 1; (c) placing the mixed material in a heating container, adding a solvent, and first extracting the mixture at 110 to 120 ° C for 3 to 5 hours, and (d) secondly extracting the obtained extract by reflux extraction A method of manufacturing a herbal composition having an anti-obesity activity.
본 발명의 항비만 활성을 갖는 한방 조성물은 피의이인을 주재로 특정한 한약재 성분을 일정한 비율로 혼합하여 조성함으로써, 체중 감량을 통한 비만 개선에 시너지 효과를 발휘하며, 액상으로 제공할 수 있어 인체에 효과적으로 흡수되어 체중감량 효과를 극대화할 수 있을 뿐만 아니라, 한방 생약재에 의해 체중감량으로 인한 부작용이 전혀 없는 건강한 체중감량이 가능하다.The herbal composition having anti-obesity activity of the present invention can be produced in the form of a mixture of certain medicinal herb components based on blood phosphorus at a certain ratio, thereby exhibiting a synergistic effect on the improvement of obesity through weight loss, It can be absorbed to maximize the weight loss effect, and it is possible to lose weight without any side effects due to weight loss by herbal medicine.
이하, 본 발명의 실시예에 대하여 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자가 용이하게 실시할 수 있도록 상세히 설명한다. 본 발명은 여러 가지 상이한 형태로 구현될 수 있으며, 여기에서 설명하는 실시예에 한정되지 않는다.Hereinafter, embodiments of the present invention will be described in detail so that those skilled in the art can easily carry out the present invention. The present invention may be embodied in many different forms and is not limited to the embodiments described herein.
본 발명의 일 실시형태에 따른 항비만 활성을 갖는 한방 조성물은 피의이인 40~65중량%, 숙지향 8~10중량%, 산약 5~8중량%, 용안육 5~8중량%, 황기 5~8중량%, 구기자 2~5중량%, 상백피 2~5중량%, 택사2~5중량%, 당귀 2~5중량%, 사인 2~5중량%, 천궁 1~2중량%, 감초 1~2중량% 및 행인 1~2중량%로 구성되는 약재 추출물을 유효성분으로 함유하는 것을 특징으로 한다. The herbal composition having anti-obesity activity according to one embodiment of the present invention contains 40 to 65% by weight of blood, 8 to 10% by weight of ambience, 5 to 8% by weight of acid, 5 to 8% 2 to 5% by weight of corn syrup, 2 to 5% by weight of corn syrup, 2 to 5% by weight of corn syrup, 2 to 5% By weight and 1 to 2% by weight as an active ingredient.
상기 13가지 추출물이 혼합된 조성물은 비만치료 및 예방에 효능이 있으며, 혈액순환저하, 소화불량, 수종 등의 병을 치료하고 식욕을 억제하는 효과가 있다. The composition containing the above-mentioned 13 extracts is effective for the treatment and prevention of obesity, and has an effect of treating diseases such as deterioration of blood circulation, poor digestion and species, and suppressing appetite.
이하에서는 본 발명을 구성하는 주요 추출물을 상술한다.Hereinafter, the main extracts constituting the present invention will be described in detail.
피의이인은 벼과에 속한 율무의 성숙한 종자를 건조한 것을 말한다. 다른 말로는 해려, 기실, 감미, 의인이라고 한다. 한약재로는 이수약류에 속하며, 몸에 불필요한 수분을 밖으로 배출시키고 비장의 기능을 보호하는 효능이 있다. 무독성이며, 몸의 불필요한 수분을 밖으로 배출시키기 때문에 수종 등의 치료에 이용되고, 비장을 보호하는 효과로 인해 폐의 기운을 강하게 하여 폐에 생긴 종기 등을 치료하는 효과가 있다. 또한 열을 내리면서 염증과 농을 없애는 작용도 겸비하고 있다.Blood phosphorus refers to dried mature seeds of yulmu belonging to paddy field. In other words, it is said to be good, airy, sweet, and righteous. Herbal medicines belong to Ishwa, and it has the effect of discharging unnecessary water out of the body and protecting the function of the spleen. It is non-toxic and is used to treat unnecessary water in the body because it discharges unnecessary water. It has the effect of treating the boils produced in the lungs by strengthening the lungs due to the effect of protecting the spleen. It also combines the function of eliminating inflammation and agriculture while lowering heat.
당귀는 혈액 순환뿐만 아니라, 이뇨, 항균, 진정, 진통의 효과를 제공하며, 천궁은 음식 섭취량 감소시 발생할 수 있는 두중통(頭重痛: 머리가 아프거나 무겁고 어지러운 증세)을 감소하여 다이어트에 나타나는 부작용을 억제할 수 있다.In addition to blood circulation, Angelica gigas provides diuretic, antibacterial, sedative, and analgesic effects, while the cynomolgus has two side effects (headache: headache or heavy and dizziness) that can occur when food intake is reduced. Can be suppressed.
천궁은 혈액 순환을 원활하게 하여 비만을 방지하는 효과가 있으며, 숙지황은 보신하는 작용을 제공하는 것으로, 기력 및 정력을 상승하고, 식사량 감소에 따른 지구력과 정신력 저하방지 작용을 제공하여 다이어트에 나타나는 부작용을 억제할 수 있다. 특히, 숙지황은 입맛을 감소시켜 다이어트를 성공적으로 실행하도록 하며, 변비를 예방하고 지구력을 유지하는 작용을 하여 효과적인 다이어트를 할 수 있게 한다.It has the effect of preventing the obesity by smoothly circulating the blood, and it provides the action of watching the Sukjihwang. It increases the energy and the energy, and provides the endurance and the prevention of the decrease of the mental power due to the reduction of the food quantity, Can be suppressed. In particular, Sukjihwang reduces the appetite to make the diet successfully, prevents constipation and maintains endurance, and enables effective diet.
황기는 콩과에 속하는 다년생초본인 단너삼의 뿌리이다. 인삼과 더불어 대표적으로 기를 보강하는 약재로 비장의 기능을 보호하고 식은땀을 그치게 하는 효능이 있다.Hwanggi is the root of Dan-Sam-gan, a perennial herb that belongs to bean. In addition to ginseng, it is a medicinal herb that strengthens the stomach and protects the function of the spleen, and has the effect of stopping the sweating.
용안육은 용안(龍眼; Dimocarpus longan Loureiro)의 헛씨껍질이며, 사인(砂仁)은 생강과에 속한 여러해살이 초본식물인 양춘사(陽春砂, Amomum villosum LOUR.)의 과실로 만든 약재이다.Yongan is a dead skin of dragon eye (Dimocarpus longan Loureiro) and Sane is a fruit made of fruit of Amanum villosum LOUR. It is a perennial herbaceous plant belonging to ginger.
택사는 택사의 덩이뿌리를 건조한 것으로서 무독성이며, 다른 말로는 수사, 택지라고 한다. 일반적으로 겨울에 채취하여 잔뿌리와 거친 껍질을 제거하고 약한 불에서 건조시켜 재료를 가공한다. 택사는 몸안에 체액과 습기가 정체되어 생기는 소변불리나 신체의 조직간격이나 체강 안에 림프액, 장액 따위가 많이 괴어 몸이 붓는 병인 수종 등을 치료하는 것으로 알려진 약재이며, 비만치료에 관해서는 그 효능이 알려진 바가 없다.Phatose is a dried phlox root of phytase and is non-toxic. In other words, it is called investigation. Generally, it is taken in winter to remove the fine roots and rough skin, and dry the material in a weak fire. Taxa is a medicinal substance known to treat urine discomfort caused by stagnation of body fluids and moisture in the body, and a variety of tissues such as lymphatic fluid and intestinal fluid in body cavity or body cavity. There is no known.
감초는 콩과에 속한 다년생초본인 감초의 뿌리이다. 맛은 달고 성질은 평하여 온갖 약의 독을 풀어주고 한약재의 강한 약성을 완화시키고, 처방 내에서 다른 약들이 서로 잘 조화될 수 있도록 도와주는 역할을 한다.Licorice is the root of licorice, a perennial herbaceous plant belonging to the legume. It tastes sweet and tastes good, releases all kinds of drug poison, relieves the strong medicine of herbal medicine, and helps other drugs to harmonize with each other in prescription.
본 발명의 바람직한 실시형태에 따른 항비만 활성을 갖는 한방 조성물은 피의이인 55중량%, 숙지향 10중량%, 산약 5중량%, 용안육 5중량%, 황기 5중량%, 구기자 3중량%, 상백피 3중량%, 택사 3중량%, 당귀 3중량%, 사인 2중량%, 천궁 2중량%, 감초 2중량%, 행인 2중량%로 구성되는 약재 추출물을 유효성분으로 함유하는 것을 특징으로 할 수 있다. The herbal composition having anti-obesity activity according to a preferred embodiment of the present invention comprises 55% by weight of bloody, 10% by weight of oriental, 5% by weight of acid, 5% by weight of lucerne, 5% by weight of erucic acid, 3% The extract of Pharmacopoeia comprising 3% by weight of phytosterol, 3% by weight of Angelicae radix, 3% by weight of Angelica giganteus, 2% by weight of sesamin, 2% by weight of licorice root, 2% by weight of licorice and 2% by weight of passerine as an active ingredient.
본 발명에 따른 항비만 활성을 갖는 한방 조성물에 있어서, 상기 추출물은 증류수, C1 내지 C4의 직쇄 또는 분지형 알코올, 및 이들의 혼합물로 이루어진 군에서 선택된 어느 1종 이상의 용매를 가하여 110 내지 120 ℃에서 3 내지 5시간 동안 추출될 수 있다.In the herbal composition having anti-obesity activity according to the present invention, the extract may be prepared by adding at least one solvent selected from the group consisting of distilled water, C 1 to C 4 linear or branched alcohols, Lt; 0 > C for 3 to 5 hours.
본 발명에 따른 항비만 활성을 갖는 한방 조성물은 상기 약재 추출물의 분획물을 유효성분으로 함유하는 것을 특징으로 할 수 있다.The herbal composition having anti-obesity activity according to the present invention may be characterized by containing a fraction of the above-mentioned medicinal extract as an active ingredient.
본 발명에 따른 항비만 활성을 갖는 한방 조성물에 있어서, 상기 분획물은 약재 추출물로부터 극성 용매, 비극성 용매 및 이들의 혼합 용매로 이루어진 군에서 선택된 1종 이상을 전개 용매로 하는 크로마토그래피(Chromatography)에 의하여 분리될 수 있다. In the herbal composition having anti-obesity activity according to the present invention, the fraction may be isolated from the medicinal extract by chromatography using at least one selected from the group consisting of a polar solvent, a non-polar solvent and a mixed solvent thereof as a development solvent Can be separated.
본 발명의 일 실시형태에 따른 항비만 활성을 갖는 한방 조성물의 제조방법은 (a) 피의이인, 숙지향, 산약, 용안육, 황기, 구기자, 상백피, 택사, 당귀, 사인, 천궁, 감초, 행인의 각 재료를 물로 세척하여 준비하는 단계; (b) 상기 각 재료를 제1항의 중량비로 혼합하는 단계; (c) 상기 혼합한 재료를 가열용기에 넣고, 용매를 첨가하여 110 내지 120℃에서 3 내지 5시간 동안 제1 추출하는 단계 및 (d) 상기 얻은 추출물을 환류 추출로 제2 추출하는 단계를 포함하는 것을 특징으로 한다. A method of producing a herbal composition having an anti-obesity activity according to an embodiment of the present invention comprises the steps of (a) preparing a composition containing an anti-obesity agent, Preparing each material by washing with water; (b) mixing the respective materials in the weight ratio of claim 1; (c) placing the mixed material in a heating container, adding a solvent, and first extracting the mixture at 110 to 120 ° C for 3 to 5 hours, and (d) secondly extracting the obtained extract by reflux extraction .
본 발명에 따른 항비만 활성을 갖는 한방 조성물의 제조방법은 상기 제2 추출한 추출물을 여과한 후, 감암 농축하는 단계; 및 동결 건조하여 분말화하는 단계를 더 포함할 수 있다. 상기와 같이 본 발명에 따라 추출된 각 성분의 추출물은 에탄올로 다시 환류 추출 후 여과액을 얻은 후 감압 농축하고 동결 건조하여 분말화하여 사용할 수 있다. The method of manufacturing a herbal composition having an anti-obesity activity according to the present invention comprises: filtering the second extracted extract; And lyophilizing and pulverizing. As described above, the extract of each component extracted according to the present invention can be recovered by refluxing with ethanol, obtaining a filtrate, concentrating it under reduced pressure, and lyophilizing it into powder.
본 발명에 따른 항비만 활성을 갖는 한방 조성물의 제조방법은 상기 제2 추출한 추출물을 극성 용매, 비극성 용매 및 이들의 혼합 용매로 이루어진 군에서 선택된 1종 이상을 전개 용매로 하는 크로마토그래피에 의하여 분획시키는 단계를 더 포함할 수 있다. The method for preparing a herbal composition having an anti-obesity activity according to the present invention is characterized in that the second extract is fractionated by chromatography using at least one selected from the group consisting of a polar solvent, a non-polar solvent and a mixed solvent thereof as a development solvent Step < / RTI >
본 발명에 따른 각 성분의 추출은 물 이외의 통상의 방법으로 추출될 수 있으며, 예를 들어, 알코올로 대표되는 유기용매의 추출방법에 따라 추출될 수 있다. 구체적으로 상기 용매는 증류수, C1 내지 C4의 직쇄 또는 분지형 알코올, 및 이들의 혼합물로 이루어진 군으로부터 선택되는 어느 1종인 것이 바람직하다. The extraction of each component according to the present invention can be carried out by a conventional method other than water, and can be extracted according to an extraction method of an organic solvent represented by, for example, alcohol. Specifically, the solvent is preferably any one selected from the group consisting of distilled water, C 1 to C 4 linear or branched alcohols, and mixtures thereof.
상기 서술한 제조방법에 따라 제조된 한방 조성물은 비만 억제 효과를 나타내며, 천연 물질로서 세포독성이 전혀 없다. The herbal composition prepared according to the above-described production method exhibits an obesity-suppressing effect, and has no cytotoxicity as a natural substance.
본 발명의 일 실시형태에 따르면, 본 발명의 추출물 또는 상기 분획물을 유효성분으로 포함하는 항비만 활성을 갖는 다이어트용 식품 또는 약학적 제제를 제공한다.According to one embodiment of the present invention, there is provided a diet food or a pharmaceutical preparation having an anti-obesity activity comprising the extract of the present invention or the fraction as an active ingredient.
본 발명의 약학적 제제는 경구 또는 비경구 투여할 수 있으며, 바람직하게는 경구 투여할 수 있다.The pharmaceutical preparations of the present invention can be administered orally or parenterally, preferably orally.
본 발명의 약제학적 조성물의 적합한 투여량은 제제화 방법, 투여 방식, 환자의 연령, 체중, 성별, 병적 상태, 음식, 투여 시간, 투여 경로, 배설 속도 및 반응 감응성과 같은 요인들에 의해 다양하게 처방될 수 있다. 본 발명의 약제학적 조성물의 투여량은 성인 기준으로 0.001-100 ㎎/kg 범위 내이다. 또한 외용제인 경우에는 성인 기준으로 1.0 내지 3.0 ml의 양으로 1일 1회 내지 5회 경구 투여할 수 있으며 1개월 이상 계속 하는 것이 좋다. 다만, 상기 투여량은 본 발명의 범위를 한정하는 것이 아니다.The appropriate dosage of the pharmaceutical composition of the present invention may vary depending on factors such as the formulation method, administration method, age, body weight, sex, pathological condition, food, administration time, administration route, excretion rate, . The dosage of the pharmaceutical composition of the present invention is within the range of 0.001-100 mg / kg on an adult basis. When the composition is an external preparation, it may be orally administered once to five times a day in an amount of 1.0 to 3.0 ml on an adult basis. However, the dose is not intended to limit the scope of the present invention.
본 발명의 약학적 제제는 당분야의 통상의 지식을 가진 자가 용이하게 실시할 수 있는 방법에 따라, 약제학적으로 허용되는 담체 및/또는 부형제를 이용하여 제제화함으로써 단위 용량 형태로 제조되거나 또는 다용량 용기 내에 내입시켜 제조될 수 있다. 이 때 제형은 오일 또는 수성 매질중의 용액, 현탁액, 시럽제 또는 유화액 형태이거나 엑시르제, 산제, 분말제, 과립제, 정제 또는 캅셀제 형태일 수도 있으며, 분산제 또는 안정화제를 추가적으로 포함할 수 있다.The pharmaceutical preparations of the present invention can be prepared in unit dosage form by formulating them with a pharmaceutically acceptable carrier and / or excipient according to a method which can be easily carried out by a person having ordinary skill in the art, Into the container. The formulations may be in the form of solutions, suspensions, syrups or emulsions in an oil or aqueous medium, or in the form of excipients, powders, powders, granules, tablets or capsules, and may additionally contain dispersing or stabilizing agents.
본 발명의 조성물이 용액으로 제공되는 경우에는 담체 성분으로서 용매, 가용화제 또는 유탁화제가 이용될 수 있고, 예컨대 물, 에탄올, 이소프로판올, 에틸카보네이트, 에틸아세테이트, 벤질 알코올, 벤질 벤조에이트, 프로필렌글리콜, 1,3-부틸글리콜 오일, 글리세롤 지방족 에스테르, 폴리에틸렌글리콜 또는 소르비탄의 지방산 에스테르가 사용될 수 있다.When the composition of the present invention is provided as a solution, a solvent, a solubilizing agent or an emulsifying agent may be used as a carrier component, and water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, 1,3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or fatty acid esters of sorbitan can be used.
본 발명의 조성물이 식품 조성물로 제공되는 경우 유효성분으로서 비만억제용 조성물들의 추출물뿐만 아니라 식품 제조 시에 통상적으로 첨가되는 성분, 예를 들어, 단백질, 탄수화물, 지방, 영양소, 조미제 및 향미제를 추가로 포함할 수 있다. 예컨대, 본 발명의 식품 조성물이 드링크제로 제조되는 경우에는 본 발명의 추출물 이외에 구연산, 액상과당, 설탕, 포도당, 초산, 사과산, 과즙, 한약 추출액 등을 추가로 포함시킬 수 있다.When the composition of the present invention is provided as a food composition, it is possible to use not only an extract of the compositions for obesity inhibition as an active ingredient but also an ingredient normally added in the manufacture of food such as protein, carbohydrate, fat, nutrients, May be further included. For example, when the food composition of the present invention is prepared as a drink, citric acid, liquid fructose, sugar, glucose, acetic acid, malic acid, fruit juice, herbal medicine extract and the like may be further added in addition to the extract of the present invention.
한편, 본 발명의 추출물은 천연물질로서 인체에 무해하며, 독성 및 부작용이 거의 없으므로 장기간 사용 시에도 안심하고 사용할 수 있으며, 특히 상기한 바와 같은 약학적 조성물 및 식품 조성물에 안전하게 적용할 수 있다.Meanwhile, since the extract of the present invention is a natural substance, it is harmless to the human body and has little toxicity and side effects. Therefore, it can be safely used even for long-term use, and can be safely applied to the pharmaceutical compositions and food compositions as described above.
이하, 본 발명을 실시예에 의해 보다 자세히 설명하지만 본 발명이 이들 실시예에 한정되는 것이 아님은 물론이다.Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to these examples.
실시예 1 내지 3. 항비만 활성을 갖는 한방 조성물의 제조Examples 1 to 3. Preparation of Oriental Compositions Having Anti-Obesity Activity
피의이인, 숙지향, 산약, 용안육, 황기, 구기자, 상백피, 택사, 당귀, 사인, 천궁, 감초, 행인의 각 재료를 물로 세척하여 재료를 준비하였다. Ingredients were prepared by washing each of the ingredients of bloody, obliquely orientated, manganese, yangyang, yanggi, gugija, manganese, phytophthora, Angelica gigas, sinensis, licorice and licorice with water.
상기 준비된 재료 각각을 하기 표 1과 같은 약재 구성으로 혼합한 후, 총 중량 1kg당 증류수 5L를 첨가하여, 120℃에서 4시간 동안 가열하였다. 가열 후, 여과액을 얻어 감압 농축하고, 농축액을 얻었다. 이를 증류수에 적절한 농도로 희석하여 실시예 1 내지 3의 항비만 활성을 갖는 한방 조성물을 제조하였다. Each of the prepared materials was mixed with the following chemical composition as shown in Table 1, and 5 L of distilled water was added per 1 kg total weight, followed by heating at 120 캜 for 4 hours. After heating, the filtrate was collected and concentrated under reduced pressure to obtain a concentrate. This was diluted to an appropriate concentration in distilled water to prepare a herbal composition having the anti-obesity activity of Examples 1 to 3.
비교예 1 내지 3. Comparative Examples 1 to 3.
상기 표 1의 중량비를 하기 표 2의 중량비로 혼합하는 것을 제외하고는, 상기 실시예의 방법과 동일하게 하여 비교예 1 내지 3의 한방 조성물을 제조하였다. The herbal compositions of Comparative Examples 1 to 3 were prepared in the same manner as in the above Examples except that the weight ratios in Table 1 were mixed at the weight ratios shown in Table 2 below.
비교예 4.Comparative Example 4
상기 비교예 1 내지 3과 별도로, 시중에 판매되는 비만 개선용 한방 차 조성물을 본 발명의 비교예 4로 하였다. Separately from the above Comparative Examples 1 to 3, a commercially available herbal composition for obesity improvement was prepared as Comparative Example 4 of the present invention.
실험예 1. 항비만 효능 평가 Experimental Example 1. Evaluation of anti-obesity efficacy
상기 일 실시예에 따라 제조된 한방 조성물의 항비만 효능을 평가하이 위하여, 상기 한방 조성물을 고지방식이와 함께 7주간 흰쥐에게 병행 공급하고, 흰쥐의 1일 평균 체중증가량, 식이섭취량 및 식이효율을 평가하였다. In order to evaluate the anti-obesity effect of the herbal composition prepared according to the above example, the herbal composition was supplied to the rats for 7 weeks with the high fat diet, and the daily average weight gain, the dietary intake and the diet efficiency Respectively.
평가방법은 정상식이를 공급한 정상군, 고지방식이를 공급한 대조군, 상기 실시예 1에서 제조된 한방 조성물을 병행 공급한 군, 본 발명의 일 비교예에서 제조된 한방 조성물을 병행 공급한 군, 본 발명의 일 실시예에서 제조된 한방 조성물을 병행 공급한 군으로 각각 분류하여 평가하고, 그 결과를 하기 표 3에 나타내었다. The evaluation methods were as follows: normal group fed with normal diet, control group fed with high-fat diet, group fed with the herbal composition prepared in Example 1, group fed with the herbal composition prepared in one comparative example of the present invention , And the herbal composition prepared in one embodiment of the present invention, and the results are shown in Table 3 below.
표 3에서 알 수 있는 바와 같이, 흰쥐의 1일 평균 체중증가량은 정상식이를 공급한 정상군에 비해, 고지방식이를 공급한 대조군에서 체중 증가가 높은 것을 확인할 수 있다. As shown in Table 3, the daily average weight gain of rats was higher in the control group fed with the high-fat diet than in the normal diet fed the normal diet.
아울러, 상기 고지방식이와 함께 병행한 비교예 1 내지 4 및 실시예 1 내지 4를 비교하면, 비교예 대비 실시예에서 제조된 한방 조성물을 병행 공급하였을 때, 보다 낮은 체중 증가율을 보여준다. 특히 실시예 2에서 제조된 한방 조성물의 경우, 가장 우수한 효과가 있는 것으로, 이는 대조군 대비 약 14%, 비교예 대비 11% 감소 효과를 갖는다. In addition, comparing Comparative Examples 1 to 4 and Examples 1 to 4, which were performed in parallel with the above-mentioned high-fat diet, showed a lower body weight increase rate when the herbal composition prepared in the Examples was supplied in parallel. In particular, the herbal composition prepared in Example 2 has the best effect, which is about 14% lower than the control and 11% lower than the comparative example.
이상에서 설명한 바와 같이, 본 발명에 따른 항비만 활성을 갖는 한방 조성물 및 그 제조방법에 대한 기술적 사상이 바람직한 실시형태로 구체적으로 기술되었으나, 상기한 실시형태는 그 설명을 위한 것이며, 그 제한을 위한 것이 아님을 주의하여야 한다. 본 발명의 기술사상 범위 내에서 다양한 변형 및 수정이 가능함은 당업자에게 명백한 것이며, 따라서 이러한 변형 및 수정이 첨부된 특허청구범위에 속함은 당연한 것이다.As described above, the technical idea of the herbal composition having anti-obesity activity according to the present invention and its production method has been specifically described in the preferred embodiment, but the above-described embodiment is for the explanation, It should be noted that it is not. It will be apparent to those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (15)
상기 조성물은 피의이인 55중량%, 숙지향 10중량%, 산약 5중량%, 용안육 5중량%, 황기 5중량%, 구기자 3중량%, 상백피 3중량%, 택사 3중량%, 당귀 3중량%, 사인 2중량%, 천궁 2중량%, 감초 2중량%, 행인 2중량%로 구성되는 약재 추출물을 유효성분으로 함유하는 항비만 활성을 갖는 한방 조성물.
The method according to claim 1,
The composition was prepared by mixing 55% by weight of bloody, 10% by weight of soybeans, 5% by weight of liquorice, 5% by weight of lucerne, 5% by weight of erucic acid, 3% by weight of guacamole, 3% A herbal composition having an anti-obesity activity containing, as an active ingredient, a medicinal extract comprising 2% by weight of a sine, 2% by weight of licorice, 2% by weight of licorice and 2%
상기 추출물은 증류수, C1 내지 C4의 직쇄 또는 분지형 알코올, 및 이들의 혼합물로 이루어진 군에서 선택된 어느 1종 이상의 용매를 가하여 110 내지 120 ℃에서 3 내지 5시간 동안 추출된 것인, 항비만 활성을 갖는 한방 조성물.
The method according to claim 1,
Wherein the extract is obtained by adding at least one solvent selected from the group consisting of distilled water, C 1 to C 4 linear or branched alcohols, and a mixture thereof, and extracting at 110 to 120 ° C for 3 to 5 hours. ≪ / RTI >
상기 약재 추출물의 분획물을 유효성분으로 함유하는, 항비만 활성을 갖는 한방 조성물.
The method according to claim 1,
A herbal composition having an anti-obesity activity, comprising the fraction of the extract of the herbal extract as an active ingredient.
상기 분획물은 약재 추출물로부터 극성 용매, 비극성 용매 및 이들의 혼합 용매로 이루어진 군에서 선택된 1종 이상을 전개 용매로 하는 크로마토그래피(Chromatography)에 의하여 분리된 것인, 항비만 활성을 갖는 한방 조성물.
5. The method of claim 4,
Wherein said fraction is isolated from a pharmacologically active ingredient by chromatographic chromatography using at least one selected from the group consisting of a polar solvent, a nonpolar solvent and a mixed solvent thereof as a developing solvent.
(b) 상기 각 재료를 제1항의 중량비로 혼합하는 단계;
(c) 상기 혼합한 재료를 가열용기에 넣고, 용매를 첨가하여 110 내지 120℃에서 3 내지 5시간 동안 제1 추출하는 단계 및
(d) 상기 얻은 추출물을 환류 추출로 제2 추출하는 단계를 포함하는, 항비만 활성을 갖는 한방 조성물의 제조방법.
(a) washing each material of bloody, obsolete, manganese, yangcheng, hwanggi, gugija, mackerel, taxa, angelica, sinus, licorice, licorice and passerby with water to prepare;
(b) mixing the respective materials in the weight ratio of claim 1;
(c) putting the mixed material into a heating container, adding a solvent, and performing first extraction at 110 to 120 ° C for 3 to 5 hours, and
(d) a second step of extracting the obtained extract by a reflux extraction.
상기 제2 추출한 추출물을 여과한 후, 감암 농축하는 단계; 및
동결 건조하여 분말화하는 단계를 더 포함하는, 항비만 활성을 갖는 한방 조성물의 제조방법.
The method according to claim 6,
Filtering the second extracted extract and then concentrating it under reduced pressure; And
Lyophilization, and pulverizing the composition. ≪ RTI ID = 0.0 > 21. < / RTI >
상기 제2 추출한 추출물을 극성 용매, 비극성 용매 및 이들의 혼합 용매로 이루어진 군에서 선택된 1종 이상을 전개 용매로 하는 크로마토그래피에 의하여 분획시키는 단계를 더 포함하는, 항비만 활성을 갖는 한방 조성물의 제조방법.
The method according to claim 6,
A step of fractionating the second extracted extract by chromatography using at least one selected from the group consisting of a polar solvent, a nonpolar solvent and a mixed solvent thereof as a development solvent, the production of a herbal composition having an anti-obesity activity Way.
상기 용매는 증류수, C1 내지 C4의 직쇄 또는 분지형 알코올, 및 이들의 혼합물로 이루어진 군으로부터 선택되는 어느 1종인, 항비만 활성을 갖는 한방 조성물의 제조방법.
The method according to claim 6,
Wherein the solvent is any one selected from the group consisting of distilled water, C 1 to C 4 linear or branched alcohols, and mixtures thereof.
A pharmaceutical preparation having an anti-obesity activity comprising the composition of claim 1.
A dietary food having an anti-obesity activity comprising the composition of claim 2.
A diet food having an anti-obesity activity comprising the composition of claim 3.
A dietary food having an anti-obesity activity comprising the composition of claim 4.
A diet food having an anti-obesity activity comprising the composition of claim 5.
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| KR20030005086A (en) | 2002-11-08 | 2003-01-15 | 주식회사 이롬라이프 | Diet composition containing freeze-dried uncooked food and dietary fiber |
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| KR20140022648A (en) | 2012-08-14 | 2014-02-25 | (주)바이오뉴트리젠 | Composition of antiobesity containing lycium chinensis leaf extract powder and betaine as effective ingredients |
| KR20150051020A (en) | 2013-11-01 | 2015-05-11 | 주식회사 차연 | Composition For Anti-obesity And Diet |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20030005086A (en) | 2002-11-08 | 2003-01-15 | 주식회사 이롬라이프 | Diet composition containing freeze-dried uncooked food and dietary fiber |
| KR20050093577A (en) | 2004-03-19 | 2005-09-23 | 조통래 | The hybrid fish farming of changable wood |
| KR20070010661A (en) | 2005-07-19 | 2007-01-24 | 삼성에스디아이 주식회사 | An electron emission source, a preparing method thereof, and an electron emission device using the same |
| KR20140022648A (en) | 2012-08-14 | 2014-02-25 | (주)바이오뉴트리젠 | Composition of antiobesity containing lycium chinensis leaf extract powder and betaine as effective ingredients |
| KR20150051020A (en) | 2013-11-01 | 2015-05-11 | 주식회사 차연 | Composition For Anti-obesity And Diet |
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