KR20190035290A - Composition for preventing or treating hangover comprising extract from germinated gemmule of bean - Google Patents
Composition for preventing or treating hangover comprising extract from germinated gemmule of bean Download PDFInfo
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- KR20190035290A KR20190035290A KR1020170124332A KR20170124332A KR20190035290A KR 20190035290 A KR20190035290 A KR 20190035290A KR 1020170124332 A KR1020170124332 A KR 1020170124332A KR 20170124332 A KR20170124332 A KR 20170124332A KR 20190035290 A KR20190035290 A KR 20190035290A
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- hangover
- extract
- present
- composition
- preventing
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/334—Foods, ingredients or supplements having a functional effect on health treating the effects of consuming alcohol, narcotics or other addictive behavior, e.g. treating hangover or reducing blood alcohol levels
Abstract
Description
본 발명은 콩발아배아 추출물을 포함하는 숙취의 예방 또는 치료용 조성물에 관한 것으로, 보다 구체적으로 본 발명은 콩발아배아 추출물 또는 이의 분획물을 포함하는 숙취의 예방 또는 치료용 약학 조성물, 상기 약학 조성물을 이용하여 숙취를 예방 또는 치료하는 방법 및 콩발아배아 추출물 또는 이의 분획물을 포함하는 숙취의 예방 또는 치료용 식품 조성물에 관한 것이다.The present invention relates to a composition for preventing or treating hangover comprising an extract of soybean germinated embryo. More particularly, the present invention relates to a pharmaceutical composition for prevention or treatment of hangover comprising a soybean germinated embryo extract or a fraction thereof, A method for preventing or treating hangover, and a food composition for prevention or treatment of hangover comprising a soybean germinated embryo extract or a fraction thereof.
알코올은 8천여 년 전부터 인류역사의 중요한 위치를 차지하여 왔으나, 1800년대에 이르러 위생환경과 정수방법이 개선되면서 식품으로써의 가치가 줄어들었고, 오늘날 사회적 향락을 위해 고농도의 술을 많이 소비하는 형태로 바뀌게 되었다. 2005년 한국의 국민 1인당 연간 소주 97병(알코올 8.11 리터)을 소비하고 있으며 이는 선진화에도 불구하고 매년 증가하는 추세에 있다.Alcohol has been an important part of human history for more than 8,000 years. By the 1800s, the value of food as a result of improved hygiene and purification methods has decreased, and nowadays it consumes a high concentration of alcohol for social enjoyment. It changed. In 2005, Korea consumed 97 bottles of soju (8.11 liters of alcohol) per capita annually, which is increasing every year despite the advancement.
약간의 알코올은 다른 진정수면약과 같이 불안을 줄여주고 편안함을 느끼게 하지만, 일반적으로 지구상에서 가장 흔히 남용되는 약물이고 막대한 의료비용과 사회적 비용을 요구하는 문제를 일으킨다. 한국의 음주로 인한 사회 경제적 손실비용은 이미 20조를 넘어서는 것으로 추정되며, 이러한 비용은 국내 총생산(GDP)의 3%를 초과하는 것으로 추정되고 있다.Some alcohols, like other sedative medicines, reduce anxiety and feel comfortable, but are generally the most commonly abused drugs on the planet and cause problems that require massive medical and social costs. It is estimated that the cost of socio-economic loss due to drinking alcohol in Korea is already over 20 trillion won, which is estimated to exceed 3% of gross domestic product (GDP).
숙취란 음주 후 나타나는 신체적, 정신적 불쾌감을 총칭하는 것으로 객관적인 증상으로는 두통, 메스꺼움, 구토, 졸음, 운동능력저하, 혈액학적 변화, 호르몬의 변화 등의 현상을 말한다. 숙취의 원인은 아직 정확하게 밝혀지지는 않았으나, 알코올 대사과정에서 발생되는 대사산물에 의한 것이라 보고되고 있다.Hanging refers to the physical and mental discomfort that appears after drinking. Objective symptoms include headache, nausea, vomiting, drowsiness, loss of exercise capacity, hematological changes, and changes in hormones. The cause of hangover has not been elucidated yet, but it is reported to be caused by the metabolites generated by alcohol metabolism.
체내로 유입된 에틸 알코올은 위장 또는 소장에서 흡수되어 혈관 내로 들어가서 간장으로 옮겨지게 된다. 간세포에는 알코올 탈수소효소(ADH, alcoholdehydrogenase)가 있어 알콜을 아세트알데히드로 산화시키고, 상기 아세트알데히드는 간세포에 있는 아세트알데히드 탈수소효소(ALDH, acetaldehyde dehydrogenase)에 의해 아세트산으로 분해되어 전신의 근육이나 지방조직으로 옮겨져 최종적으로는 탄산가스와 물로 분해된다. 또한, 상기 아세트알데히드 탈수소효소에는 아세트알데히드가 저농도이더라도 산화를 개시하는 Ⅱ 형과 아세트알데히드가 고농도가 되지 않으면 작용을 하지 않는 I 형이 있으나, 동양인은 일반적으로 Ⅱ 형 아세트알데히드 효소가 결핍 또는 부족하기 때문에 아세트알데히드의 산화가 서양인에 비해 느린 편이다. 산화되지 못한 아세트알데히드 및/또는 에탄올은 정상적인 신진대사를 방해하여 다양한 숙취현상을 느끼게 한다.Ethanol fed into the body is absorbed from the stomach or small intestine, enters the blood vessels and is transferred to the liver. Hepatocytes have an alcohol dehydrogenase (ADH) to oxidize alcohol to acetaldehyde. The acetaldehyde is decomposed into acetic acid by acetaldehyde dehydrogenase (ALDH) in hepatocytes, And finally decomposed into carbon dioxide and water. In addition, the acetaldehyde dehydrogenase has type I, which initiates oxidation even when acetaldehyde is low in concentration, and type I, which does not act if the concentration of acetaldehyde is high. However, Asians generally have deficiency or lack of type II acetaldehyde enzyme Therefore, the oxidation of acetaldehyde is slower than that of Westerners. Non-oxidized acetaldehyde and / or ethanol may interfere with normal metabolism and cause a variety of hangover symptoms.
한국의 음주문화에 대한 사회적 배경으로 인하여 숙취해소를 위한 제품에 대한 소비자의 요구가 지속되고 있으며, 숙취경감을 위하여 다양한 연구가 이루어지고 실제 다양한 제품들이 시중에 판매되는 새롭게 등장하고 있다. 예를 들어, 한국등록특허 제10-0552398호에는 작두콩 추출물을 포함하는 숙취해소용 음료 조성물이 개시되어 있고, 한국등록특허 제10-0989869호에는 콩나물 발효액을 함유하는 숙취해소 음료가 개시되어 있으며, 한국등록특허 제10-1601947호에는 땅콩새싹 추출물 및 울금 추출물을 포함하는 숙취해소 음료 조성물이 개시되어 있다. Due to the social background of the drinking culture in Korea, consumers' demand for products to relieve hangovers is continuing. Various researches have been carried out in order to alleviate hangovers, and a variety of products are being newly marketed in the market. Korean Patent No. 10-0552398, for example, discloses a beverage for hangover small beverage composition containing a soybean extract, Korean Patent No. 10-0989869 discloses a hangover drink containing a fermented bean sprout, Korean Patent No. 10-1601947 discloses a hangover-resilient beverage composition comprising a peanut sprout extract and a curd extract.
그러나, 이들 제품은 실제 만들어진 최종 완제품의 효능에 대해서 객관적 검증이 미흡한 상황이기에 실제 숙취해소 음료를 필요로 하는 소비자들에게 신뢰도가 전반적으로 높지 않은 것이 현실이다. 이에 숙취해소 효능의 검증을 통해서 실제 소비자들이 제품을 음용한 뒤에 효과를 봄으로써 소비자들의 신뢰를 얻을 뿐 아니라 실제 과다한 음주로 인한 사회적인 손실을 줄이고, 더불어 개인의 건강한 생활에도 도움을 줄 수 있는 제품의 개발이 절실히 요구되고 있다.However, since these products are not subject to objective validation of the efficacy of the finished final product, it is a reality that the reliability is not generally high for consumers who need a hangover drink. Therefore, it is necessary to examine the efficacy of the hangover to evaluate the effectiveness of the product after drinking it, not only to gain the trust of the consumers, but also to reduce the social loss due to excessive drinking and to help the healthy life of the individual. Development is urgently required.
이와 같은 배경하에, 본 발명자들은 보다 효과적으로 숙취를 해소할 수 있는 방법을 개발하고자 예의 연구노력한 결과, 콩발아배아 추출물이 혈중 알코올의 수준을 효과적으로 감소시킬 수 있음을 확인하고, 본 발명을 완성하였다.Under these circumstances, the inventors of the present invention have made extensive efforts to develop a method for effectively dissolving hangover, and as a result, they have confirmed that the soybean germinated embryo extract can effectively reduce the level of blood alcohol and completed the present invention.
본 발명의 하나의 목적은 콩발아배아 추출물 또는 이의 분획물을 포함하는 숙취의 예방 또는 치료용 약학 조성물을 제공하는 것이다.It is an object of the present invention to provide a pharmaceutical composition for preventing or treating hangover comprising a soybean germinated embryo extract or a fraction thereof.
본 발명의 다른 목적은 상기 약학 조성물을 이용하여 숙취를 예방 또는 치료하는 방법을 제공하는 것이다.Another object of the present invention is to provide a method for preventing or treating hangover using the above pharmaceutical composition.
본 발명의 또 다른 목적은 콩발아배아 추출물 또는 이의 분획물을 포함하는 숙취의 예방 또는 치료용 식품 조성물을 제공하는 것이다.Another object of the present invention is to provide a food composition for preventing or treating hangover comprising a soybean germinated embryo extract or a fraction thereof.
본 발명자들은 보다 효과적으로 숙취를 해소할 수 있는 방법을 개발하고자 다양한 연구를 수행하던 중, 콩발아배아의 추출물이 혈중 알코올을 효과적으로 감소시킬 수 있음을 확인하였다. 지금까지 콩과 관련된 숙취해소 효과로는 콩나물의 뿌리부분에 다량으로 포함된 아스파라긴에 의한 숙취효과가 공지되어 있다. 그러나, 콩발아배아로부터 유래된 성분이 숙취해소 효과를 나타낸다는 점에 대하여는 지금까지 전혀 알려져 있지 않았고, 본 발명자에 의하여 최초로 규명되었다.The inventors of the present invention confirmed that the extract of soybean germinated embryo can effectively reduce the blood alcohol while carrying out various studies to develop a method of solving the hangover more effectively. So far, the hangover effect caused by asparagine, which is contained in a large amount in the root portion of bean sprouts, has been known as a hangover relieving effect related to soybean. However, the fact that a component derived from a soybean germinated embryo exhibits a hangover-eliminating effect has not been known at all, and was firstly described by the present inventors.
상기 목적을 달성하기 위한 하나의 양태로서, 본 발명은 콩발아배아 추출물 또는 이의 분획물을 포함하는, 숙취의 예방 또는 치료용 약학 조성물을 제공한다.In one aspect of the present invention, there is provided a pharmaceutical composition for preventing or treating hangover, comprising a soybean germinated embryo extract or a fraction thereof.
본 발명의 용어 "콩발아배아"란, 콩에서 분리한 배아를 발아시킨 발아배아를 의미한다. 콩 발아배아의 제조방법은 본 발명자들의 선행연구에 의하여 공지된 바 있으며(한국공개특허 제2013-0057173호), 구체적으로 상기 콩 발아배아는 콩으로부터 분리된 배아를 발아시켜 수득하는 것일 수 있으나, 이에 제한되는 것은 아니다. 상기 콩 발아배아 추출물의 숙취의 예방 또는 치료 효과는 지금까지 전혀 알려져 있지 않았고, 본 발명자들에 의하여 최초로 규명되었다.The term "soybean germinated embryo" of the present invention means a germinated embryo obtained by germinating an embryo isolated from soybean. A method for producing a soybean germinated embryo has been known from previous studies of the present inventors (Korean Laid-Open Patent Application No. 2013-0057173). Specifically, the soybean germinated embryo may be obtained by germinating an embryo isolated from soybean, But is not limited thereto. The effect of preventing or treating the hangover of the germinated germ extract of the present invention has not been known at all and has been identified for the first time by the present inventors.
본 발명의 용어 "추출물"이란, 콩 발아배아를 추출 처리하여 얻어지는 추출액, 상기 추출액의 희석액이나 농축액, 상기 추출액을 건조하여 얻어지는 건조물, 상기 추출액의 조정제물이나 정제물, 또는 이들의 혼합물 등, 추출액 자체 및 추출액을 이용하여 형성 가능한 모든 제형의 추출물을 포함한다. The term "extract " of the present invention means an extract obtained by extracting a soybean germinated embryo, a diluted solution or concentrate of the extract, a dried product obtained by drying the extract, a controlled preparation or a purified product of the extracted solution, Itself and extracts of all formulations which can be formed using extracts.
본 발명에 있어서, 상기 콩 발아배아를 추출하는 방법은 특별히 제한되지 않으며, 당해 기술 분야에서 통상적으로 사용하는 방법에 따라 추출할 수 있다. 상기 추출 방법의 비제한적인 예로는, 열수 추출법, 초음파 추출법, 여과법, 환류 추출법 등을 들 수 있으며, 이들은 단독으로 수행되거나 2종 이상의 방법을 병용하여 수행될 수 있다.In the present invention, the method for extracting the soybean germinated embryo is not particularly limited and may be carried out according to a method commonly used in the art. Non-limiting examples of the extraction method include hydrothermal extraction, ultrasonic extraction, filtration, and reflux extraction. These may be performed alone or in combination with two or more methods.
본 발명에서 상기 콩 발아배아를 추출하는 데 사용되는 추출 용매의 종류는 특별히 제한되지 않으며, 당해 기술 분야에서 공지된 임의의 용매를 사용할 수 있다. 상기 추출 용매의 비제한적인 예로는 물, 알코올 또는 이들의 혼합 용매 등을 들 수 있으며, 이들은 단독으로 사용되거나 1종 이상 혼합하여 사용될 수 있다. 알코올을 용매로 사용하는 경우에는 구체적으로 탄소수 1 내지 4의 알코올을 사용할 수 있다.In the present invention, the kind of the extraction solvent used for extracting the soybean germinated embryo is not particularly limited, and any solvent known in the art can be used. Non-limiting examples of the extraction solvent include water, alcohol, and a mixed solvent thereof. These solvents may be used alone or in combination. When an alcohol is used as a solvent, an alcohol having 1 to 4 carbon atoms can be specifically used.
본 발명의 용어 "분획물"이란, 여러 다양한 구성 성분들을 포함하는 혼합물로부터 특정 성분 또는 특정 성분 그룹을 분리하기 위하여 분획을 수행하여 얻어진 결과물을 의미한다.The term "fraction " of the present invention means a product obtained by performing fractionation to separate a specific component or a specific component group from a mixture containing various components.
본 발명에서 상기 분획물을 얻는 분획 방법은 특별히 제한되지 않으며, 당해 기술 분야에서 통상적으로 사용하는 방법에 따라 수행될 수 있다. 상기 분획 방법의 비제한적인 예로는, 본 발명의 콩 발아배아를 추출하여 얻은 추출물에 소정의 용매를 처리하여 상기 추출물로부터 분획물을 얻는 방법을 들 수 있다.The fractionation method for obtaining the fraction in the present invention is not particularly limited and may be carried out according to a method commonly used in the art. As a non-limiting example of the above-mentioned fractionation method, there can be mentioned a method of treating a soybean germinated embryo extract of the present invention with a predetermined solvent to obtain a fraction from the extract.
본 발명에서 상기 분획물을 얻는 데 사용되는 분획 용매의 종류는 특별히 제한되지 않으며, 당해 기술 분야에서 공지된 임의의 용매를 사용할 수 있다. 상기 분획 용매의 비제한적인 예로는 물, 알코올 등의 극성 용매; 헥산(Hexan), 에틸 아세테이트(Ethyl acetate), 클로로포름(Chloroform), 디클로로메탄(Dichloromethane) 등의 비극성 용매 등을 들 수 있다. 이들은 단독으로 사용되거나 1종 이상 혼합하여 사용될 수 있다. 상기 분획 용매 중 알코올을 사용하는 경우에는 구체적으로 탄소수 1 내지 4의 알코올을 사용할 수 있다.The kind of the fraction solvent used for obtaining the fraction in the present invention is not particularly limited, and any solvent known in the art can be used. Non-limiting examples of the fraction solvent include polar solvents such as water and alcohol; And non-polar solvents such as hexane, ethyl acetate, chloroform, and dichloromethane. These may be used alone or in combination of one or more. When an alcohol is used in the fraction solvent, an alcohol having 1 to 4 carbon atoms can be specifically used.
본 발명의 콩 발아배아 추출물은 소야사포닌(soyasaponin)을 포함하는 것일 수 있다.The soybean germinated embryo extract of the present invention may contain soyasaponin.
본 발명의 용어, “소야사포닌(soyasaponin)”이란, 콩에 포함되어 있는 식물성 스테롤(phytosterol)의 일종으로, 스테로이드 또는 트리테르페노이드와 같은 아글리콘(Aglycone) 구조에 기초하여 복잡하고 다양한 분자 구조를 보인다. 상기 소야사포닌의 구체적인 예는 Soyasaponin Aa, Soyasaponin Ab, Soyasaponin Ac, Soyasaponin Ae, Soyasaponin Af, Soyasaponin Ba, Soyasaponin Bb, Soyasaponin Bc, Soyasaponin Bd, Soyasaponin Be, Soyasaponin βg, Soyasaponin βa, soyasaponin Ag, soyasaponin Ad, soyasaponin Ah, soyasaponin γg일 수 있지만, 이에 제한되지 않는다.The term " soyasaponin " of the present invention is a kind of phytosterol contained in soybeans, and it is a phytosterol which is based on aglycone structure such as steroid or triterpenoid, Respectively. Specific examples of the soy saff saponin include Soyasaponin Aa, Soyasaponin Ab, Soyasaponin Ac, Soyasaponin Ae, Soyasaponin Af, Soyasaponin Ba, Soyasaponin Bb, Soyasaponin Bc, Soyasaponin Bd, Soyasaponin Be, Soyasaponin βg, Soyasaponin βa, Ah, soyasaponin gamma g, but is not limited thereto.
본 발명의 용어 "숙취"란, 음주 후 나타나는 신체적, 정신적 불쾌감을 총칭하는 것으로 객관적인 증상으로는 두통, 메스꺼움, 구토, 졸음, 운동능력저하, 혈액학적 변화, 호르몬의 변화 등의 현상을 말한다. 숙취의 원인은 아직 정확하게 밝혀지지는 않았으나, 일반적으로는 알코올 대사과정에서 발생되는 대사산물인 아세트알데히드와 관련이 높다는 것이 알려져 있다. 곧, 일반적으로 숙취는 체내 잔존하는 아세트알데히드 농도가 높을 경우 나타나는 것으로 알려져 있다.The term "hangover" of the present invention refers to the physical and mental discomforts appearing after drinking. Examples of objective symptoms include headaches, nausea, vomiting, drowsiness, decreased exercise capacity, hematologic changes, and changes in hormones. The cause of hangover has not yet been elucidated, but it is generally known to be associated with acetaldehyde, a metabolite that is produced during alcohol metabolism. It is generally known that hangover occurs when the concentration of acetaldehyde remaining in the body is high.
본 발명의 용어 "예방"이란, 본 발명의 조성물을 포함하는 숙취의 예방 또는 치료용 약학적 조성물의 투여로 숙취의 발생을 저해 또는 지연시키는 모든 행위를 의미한다. The term "prevention" of the present invention means all actions that inhibit or delay the occurrence of hangover by administration of a pharmaceutical composition for preventing or treating hangover comprising the composition of the present invention.
본 발명의 용어 "치료" 또는 "개선"이란, 본 발명의 조성물을 투여하여 숙취의 증세가 호전되거나 이롭게 변경되는 모든 행위를 의미한다.The term " treatment "or" improvement "of the present invention means any action that improves or alters the condition of hangover by administering the composition of the present invention.
본 발명의 약학 조성물은 총 조성물의 중량 대비 상기 추출물을 0.0001 내지 50 중량%로 포함할 수 있으며, 구체적으로 0.01 중량% 내지 10 중량%로 포함할 수 있으나, 이에 제한되지 않는다.The pharmaceutical composition of the present invention may contain the extract in an amount of 0.0001 to 50% by weight based on the weight of the total composition, and may include, but is not limited to, 0.01 to 10% by weight.
상기 본 발명의 약학 조성물은 약학 조성물의 제조에 통상적으로 사용하는 약학적으로 허용가능한 담체, 부형제 또는 희석제를 추가로 포함할 수 있고, 상기 담체는 비자연적 담체(non-naturally occuring carrier)를 포함할 수 있다. The pharmaceutical composition of the present invention may further comprise a pharmaceutically acceptable carrier, excipient or diluent conventionally used in the production of a pharmaceutical composition, and the carrier may include a non-naturally occuring carrier .
본 발명의 용어 "약학적으로 허용가능한"이란 상기 조성물에 노출되는 세포나 인간에게 독성이 없는 특성을 나타내는 것을 의미한다.The term "pharmaceutically acceptable" of the present invention means that it exhibits properties that are not toxic to the cells or humans exposed to the composition.
구체적으로, 상기 약학 조성물은, 각각 통상의 방법에 따라 산제, 과립제, 정제, 캡슐제, 현탁액, 에멀젼, 시럽, 에어로졸 등의 경구형 제형, 외용제, 좌제 및 멸균 주사용액의 형태로 제형화하여 사용될 수 있다. 본 발명에서, 상기 약학 조성물에 포함될 수 있는 담체, 부형제 및 희석제로는 락토즈, 덱스트로즈, 수크로스, 솔비톨, 만니톨, 자일리톨, 에리스리톨, 말티톨, 전분, 아카시아 고무, 알지네이트, 젤라틴, 칼슘 포스페이트, 칼슘 실리케이트, 셀룰로즈, 메틸 셀룰로즈, 미정질 셀룰로스, 폴리비닐 피롤리돈, 물, 메틸히드록시벤조에이트, 프로필히드록시벤조에이트, 탈크, 마그네슘 스테아레이트 및 광물유를 들 수 있다. 제제화할 경우에는 보통 사용하는 충진제, 증량제, 결합제, 습윤제, 붕해제, 계면활성제 등의 희석제 또는 부형제를 사용하여 조제된다. 경구투여를 위한 고형제제에는 정제, 환제, 산제, 과립제, 캡슐제 등이 포함되며, 이러한 고형제제는 적어도 하나 이상의 부형제 예를 들면, 전분, 칼슘카보네이트(calcium carbonate), 수크로스(sucrose) 또는 락토오스(lactose), 젤라틴 등을 섞어 조제된다. 또한 단순한 부형제 이외에 마그네슘 스티레이트, 탈크 같은 윤활제들도 사용된다. 경구를 위한 액상 제제로는 현탁제, 내용액제, 유제, 시럽제 등이 해당되는 데 흔히 사용되는 단순희석제인 물, 리퀴드 파라핀 이외에 여러 가지 부형제, 예를 들면 습윤제, 감미제, 방향제, 보존제 등이 포함될 수 있다. 비경구 투여를 위한 제제에는 멸균된 수용액, 비수성용제, 현탁제, 유제, 동결건조 제제, 좌제가 포함된다. 비수성용제, 현탁제로는 프로필렌글리콜(propylene glycol), 폴리에틸렌 글리콜, 올리브 오일과 같은 식물성 기름, 에틸올레이트와 같은 주사 가능한 에스테르 등이 사용될 수 있다. 좌제의 기제로는 위텝솔(witepsol), 마크로골, 트윈(tween) 61, 카카오지, 라우린지, 글리세로제라틴 등이 사용될 수 있다. Specifically, the pharmaceutical composition may be formulated in the form of powders, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols and the like, oral preparations, suppositories and sterilized injection solutions according to a conventional method . In the present invention, the carrier, excipient and diluent which may be contained in the pharmaceutical composition include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, Calcium silicate, cellulose, methylcellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil. In the case of formulation, a diluent or excipient such as a filler, an extender, a binder, a wetting agent, a disintegrant, or a surfactant is usually used. Solid formulations for oral administration include tablets, pills, powders, granules, capsules and the like, which may contain at least one excipient such as starch, calcium carbonate, sucrose or lactose lactose, gelatin, and the like. In addition to simple excipients, lubricants such as magnesium stearate and talc are also used. Liquid preparations for oral use may include various excipients such as wetting agents, sweetening agents, fragrances, preservatives, etc. in addition to water and liquid paraffin, which are simple diluents commonly used in suspension, liquid solutions, emulsions and syrups have. Formulations for parenteral administration include sterilized aqueous solutions, non-aqueous solutions, suspensions, emulsions, freeze-dried preparations, and suppositories. Examples of the suspending agent include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like. Examples of the suppository base include witepsol, macrogol, tween 61, cacao butter, laurin, glycerogelatin and the like.
본 발명의 숙취 예방 또는 치료용 약학 조성물은 상기 주요성분 이외에도 숙취 효과를 더욱 증대시키기 위한 보조성분으로서 황기 추출물, 연자육 추출물, 헛개나무열매 추출물 또는 이들의 혼합물을 추가로 포함할 수 있다. 또한, 바람직하게는 비타민 B군, 비타민 C, 비타민 E, 또는 베타카로틴과 같은 비타민, Ca, Mg, 또는 Zn 등의 미네랄 성분, 레시틴 등의 인지질, 알라닌 또는 타우린 등의 아미노산, 사과산, 구연산, 백설탕, 액상과당, 올리고당, 영지, 또는 이들의 혼합물을 더욱 포함할 수 있다.The pharmaceutical composition for preventing or treating hangover according to the present invention may further comprise, as an auxiliary component for further enhancing the hangover effect, hwanggi extract, prawn extract, hinoki fruit extract or a mixture thereof, in addition to the main components. It is also preferable to use vitamins such as vitamin B group, vitamin C, vitamin E or beta carotene, minerals such as Ca, Mg or Zn, phospholipids such as lecithin, amino acids such as alanine or taurine, , Liquid fructose, oligosaccharides, ginseng, or a mixture thereof.
다른 양태로서, 본 발명은 상기 약학 조성물을 숙취 증상을 가지거나, 가질 위험이 있는 개체에 투여하는 단계를 포함하는, 숙취의 예방 또는 치료 방법을 제공한다.In another aspect, the present invention provides a method for preventing or treating hangover, comprising administering the pharmaceutical composition to a subject having or at risk of having a hangover symptom.
본 발명의 용어 "투여"란 적절한 방법으로 개체에게 소정의 물질을 도입하는 것을 의미한다. The term "administering" of the present invention means introducing a given substance into an individual in a suitable manner.
본 발명의 용어 "개체"란 숙취 증상을 보이거나 보일 위험이 있는 인간을 포함한 쥐, 생쥐, 가축 등의 모든 동물을 의미한다. 구체적인 예로, 인간을 포함한 포유동물일 수 있다.The term "individual" of the present invention means all animals such as rats, mice, livestock, and the like, including humans who show or are at risk of developing a hangover symptom. As a specific example, it may be a mammal including a human.
본 발명의 숙취의 예방 또는 치료 방법은 구체적으로, 인간을 제외한 개체에 콩 발아배아 추출물 또는 이의 분획물을 포함하는 숙취의 예방 또는 치료용 약학 조성물을 약학적으로 유효한 양으로 투여하는 단계를 포함할 수 있다. The method for preventing or treating hangover according to the present invention may specifically include a step of administering a pharmaceutically effective amount of a pharmaceutical composition for prevention or treatment of hangover comprising a soybean germinated embryo extract or a fraction thereof to a subject other than human have.
본 발명의 용어 "약학적으로 유효한 양"이란 의학적 치료에 적용 가능한 합리적인 수혜/위험 비율로 질환을 치료하기에 충분하며 부작용을 일으키지 않을 정도의 양을 의미하며, 유효 용량 수준은 환자의 성별, 연령, 체중, 건강상태, 질병의 종류, 중증도, 약물의 활성, 약물에 대한 민감도, 투여 방법, 투여 시간, 투여 경로, 및 배출 비율, 치료 기간, 배합 또는 동시에 사용되는 약물을 포함한 요소 및 기타 의학 분야에 잘 알려진 요소에 따라 당업자에 의해 용이하게 결정될 수 있다.The term "pharmaceutically effective amount" of the present invention means an amount sufficient to treat a disease at a reasonable benefit / risk ratio applicable to medical treatment and not causing side effects. The effective dose level is determined by the sex, age And other medical fields, including drugs used in combination or concurrently, with respect to body weight, health status, type of disease, severity, activity of the drug, sensitivity to the drug, method of administration, administration time, route of administration, Can be readily determined by those skilled in the art according to well known factors.
구체적으로 본 발명의 조성물은 고형분을 기준으로 1일 0.0001 내지 100 mg/체중 kg으로, 더욱 구체적으로 0.001 내지 100 mg/체중 kg으로 투여할 수 있다. 투여는 상기 권장 투여량을 하루에 한 번 투여할 수도 있고, 수회 나누어 투여할 수도 있다.Specifically, the composition of the present invention may be administered at a dose of 0.0001 to 100 mg / kg body weight per day, more specifically 0.001 to 100 mg / kg body weight, based on the solid content. The administration may be such that the recommended dose is administered once a day or divided into several doses.
본 발명의 숙취의 예방 또는 치료 방법에서, 상기 조성물을 투여하는 투여 경로 및 투여 방식은 특별히 제한되지 않으며, 목적하는 해당 부위에 상기 조성물을 포함하는 조성물이 도달할 수 있는 한 임의의 투여 경로 및 투여 방식에 따를 수 있다. 구체적으로, 상기 조성물은 경구 또는 비경구의 다양한 경로를 통하여 투여될 수 있으며, 그 투여 경로의 비제한적인 예로는, 구강, 직장, 국소, 정맥내, 복강내, 근육내, 동맥내, 경피, 비측내 또는 흡입 등을 통하여 투여되는 것을 들 수 있다.In the method for preventing or treating hangover of the present invention, the administration route and method of administering the composition are not particularly limited, and any route of administration and administration can be used as long as the composition containing the composition can reach the desired site It is possible to follow the method. Specifically, the composition may be administered orally or parenterally through various routes. Non-limiting examples of routes of administration include oral, rectal, topical, intravenous, intraperitoneal, intramuscular, intraarterial, transdermal, Intramuscularly or through inhalation or the like.
또 다른 양태로서, 본 발명은 콩발아배아 추출물을 유효성분으로 포함하는, 숙취 예방 또는 개선용 식품 조성물을 제공한다.In another aspect, the present invention provides a food composition for preventing or improving hangover, comprising a soybean germinated embryo extract as an active ingredient.
상기 조성물 및 숙취에 대해서는 상기에서 설명한 바와 같다.The above composition and hangover are as described above.
본 발명의 용어, "개선"이란, 상기 조성물의 투여로 숙취 증상이 호전되거나 이롭게 변경되는 모든 행위를 의미한다.The term "improvement" of the present invention means all the actions that improve or ameliorate the symptoms of hangover with the administration of the composition.
본 발명의 용어, "식품"은 육류, 소시지, 빵, 초콜릿, 캔디류, 스낵류, 과자류, 피자, 라면, 기타 면류, 껌류, 아이스크림류를 포함한 낙농제품, 각종 스프, 음료수, 차, 드링크제, 알코올음료, 비타민 복합제, 건강 기능 식품 및 건강 식품 등이 있으며, 통상적인 의미에서의 식품을 모두 포함한다.The term "food" of the present invention includes dairy products such as meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen and other noodles, gums, ice cream, various soups, drinks, tea, , A vitamin complex, a health functional food, and a health food, all of which include foods in a conventional sense.
상기 건강 기능(성) 식품(functional food)이란, 특정보건용 식품(food for special health use, FoSHU)과 동일한 용어로, 영양 공급 외에도 생체조절기능이 효율적으로 나타나도록 가공된 의학, 의료효과가 높은 식품을 의미한다. 여기서 "기능(성)"이라 함은 인체의 구조 및 기능에 대하여 영양소를 조절하거나 생리학적 작용 등과 같은 보건용도에 유용한 효과를 얻는 것을 의미한다. 본 발명의 식품은 당 업계에서 통상적으로 사용되는 방법에 의하여 제조가능하며, 상기 제조시에는 당 업계에서 통상적으로 첨가하는 원료 및 성분을 첨가하여 제조할 수 있다. 또한 상기 식품의 제형 또한 식품으로 인정되는 제형이면 제한 없이 제조될 수 있다. 본 발명의 식품용 조성물은 다양한 형태의 제형으로 제조될 수 있으며, 일반 약품과는 달리 식품을 원료로 하여 약품의 장기 복용 시 발생할 수 있는 부작용 등이 없는 장점이 있고, 휴대성이 뛰어나, 본 발명의 식품은 숙취의 예방 또는 개선의 효과를 증진시키기 위한 보조제로 섭취가 가능하다.The term "functional food" as used herein means the same term as "food for special health use" (FoSHU). In addition to nutrition, It means food. Here, the term "function (surname)" means that the structure and function of the human body have a beneficial effect for health use such as controlling nutrients or physiological action. The food of the present invention can be prepared by a method commonly used in the art and can be prepared by adding raw materials and ingredients which are conventionally added in the art. In addition, the formulations of the food can also be produced without restrictions as long as they are formulations recognized as food. The composition for food of the present invention can be manufactured in various forms, and unlike general pharmaceuticals, it has the advantage that there is no side effect that may occur when a drug is used for a long period of time, and is excellent in portability, Can be ingested as an adjuvant to promote the effect of prevention or improvement of hangover.
상기 건강 식품(health food)은 일반식품에 비해 적극적인 건강유지나 증진 효과를 가지는 식품을 의미하고, 건강보조식품(health supplement food)은 건강보조 목적의 식품을 의미한다. 경우에 따라, 건강 기능 식품, 건강식품, 건강보조식품의 용어는 호용된다.The health food refers to a food having an active health promotion or promotion effect compared with a general food, and a health supplement food refers to a food for health assistance. In some cases, the terms health functional foods, health foods, and health supplements are used.
구체적으로, 상기 건강 기능 식품은 본 발명의 추출물을 음료, 차류, 향신료, 껌, 과자류 등의 식품 소재에 첨가하거나, 캡슐화, 분말화, 현탁액 등으로 제조한 식품으로, 이를 섭취할 경우 건강상 특정한 효과를 가져 오는 것을 의미하나, 일반 약품과는 달리 식품을 원료로 하여 약품의 장기 복용 시 발생할 수 있는 부작용이 없는 장점이 있다.Specifically, the health functional food is a food prepared by adding the extract of the present invention to food materials such as beverage, tea, spice, gum and confectionery, or by encapsulation, powdering, suspension or the like, But it has the advantage that there is no side effect that can occur when the food is used as a raw material and long-term use of the drug.
본 발명의 식품 조성물은, 일상적으로 섭취하는 것이 가능하기 때문에 숙취의 예방 또는 개선에 대하여 높은 효과를 기대할 수 있으므로, 매우 유용하게 사용될 수 있다.Since the food composition of the present invention can be routinely ingested, high efficacy against the prevention or improvement of hangover can be expected, so that it can be very usefully used.
상기 식품 조성물은 생리학적으로 허용 가능한 담체를 추가로 포함할 수 있는데, 담체의 종류는 특별히 제한되지 않으며 당해 기술 분야에서 통상적으로 사용되는 담체라면 어느 것이든 사용할 수 있다.The food composition may further comprise a physiologically acceptable carrier. The type of carrier is not particularly limited, and any carrier conventionally used in the art can be used.
또한, 상기 식품 조성물은 식품 조성물에 통상 사용되어 냄새, 맛, 시각 등을 향상시킬 수 있는 추가 성분을 포함할 수 있다. 예들 들어, 비타민 A, C, D, E, B1, B2, B6, B12, 니아신(niacin), 비오틴(biotin), 폴레이트(folate), 판토텐산(panthotenic acid) 등을 포함할 수 있다. 또한, 아연(Zn), 철(Fe), 칼슘(Ca), 크롬(Cr), 마그네슘(Mg), 망간(Mn), 구리(Cu), 크륨(Cr) 등의 미네랄을 포함할 수 있다. 또한, 라이신, 트립토판, 시스테인, 발린 등의 아미노산을 포함할 수 있다. In addition, the food composition may contain additional components that are commonly used in food compositions and can improve odor, taste, visual appearance, and the like. For example, vitamins A, C, D, E, B1, B2, B6, B12, niacin, biotin, folate, panthotenic acid and the like. In addition, it may include minerals such as zinc (Zn), iron (Fe), calcium (Ca), chromium (Cr), magnesium (Mg), manganese (Mn), copper (Cu) It may also include amino acids such as lysine, tryptophan, cysteine, valine, and the like.
또한, 상기 식품 조성물은 방부제(소르빈산 칼륨, 벤조산나트륨, 살리실산, 데히드로초산나트륨 등), 살균제(표백분과 고도 표백분, 차아염소산나트륨 등), 산화방지제(부틸히드록시아니졸(BHA), 부틸히드록시톨류엔(BHT) 등), 착색제(타르색소 등), 발색제(아질산 나트륨, 아초산 나트륨 등), 표백제(아황산나트륨), 조미료(MSG 글루타민산나트륨 등), 감미료(둘신, 사이클레메이트, 사카린, 나트륨 등), 향료(바닐린, 락톤류 등), 팽창제(명반, D-주석산수소칼륨 등), 강화제, 유화제, 증점제(호료), 피막제, 검기초제, 거품억제제, 용제, 개량제 등의 식품 첨가물(food additives)을 포함할 수 있다. 상기 첨가물은 식품의 종류에 따라 선별되고 적절한 양으로 사용될 수 있다.In addition, the food composition may contain at least one kind selected from the group consisting of preservatives (potassium sorbate, sodium benzoate, salicylic acid, sodium dehydroacetate), disinfectants (such as bleaching powder and highly bleached white powder, sodium hypochlorite), antioxidants (butylhydroxyanisole (BHA) (Sodium nitrite), bleach (sodium sulfite), seasoning (sodium MSG glutamate, etc.), sweeteners (dicin, cyclamate, saccharin, etc.), coloring agents , Sodium, etc.), perfume (vanillin, lactones, etc.), swelling agents (alum, potassium hydrogen D-tartrate), emulsifiers, thickeners (foams), encapsulating agents, gum bases, foam inhibitors, solvents, And may include food additives. The additives may be selected and used in appropriate amounts depending on the type of food.
본 발명의 추출물은 그대로 첨가하거나 다른 식품 또는 식품 성분과 함께 사용될 수 있고, 통상적인 방법에 따라 적절하게 사용될 수 있다. 유효성분의 혼합양은 그의 사용 목적(예방, 건강 또는 치료적 처치)에 따라 적합하게 결정될 수 있다. 일반적으로, 식품 또는 음료의 제조시에 본 발명의 식품 조성물은 식품 또는 음료에 대하여 50 중량부 이하, 구체적으로 20 중량부 이하의 양으로 첨가될 수 있다. 그러나 건강 및 위생을 목적으로 장기간 섭취할 경우에는 상기 범위 이하의 함량을 포함할 수 있으며, 안전성 면에서 아무런 문제가 없기 때문에 유효성분은 상기 범위 이상의 양으로도 사용될 수 있다.The extract of the present invention can be added intact or used together with other food or food ingredients, and can be suitably used according to conventional methods. The amount of the active ingredient to be mixed can be suitably determined according to its intended use (prevention, health or therapeutic treatment). Generally, the food composition of the present invention may be added in an amount of not more than 50 parts by weight, specifically not more than 20 parts by weight, based on the food or beverage, when the food or drink is prepared. However, in case of long-term ingestion for health and hygiene purposes, the active ingredient may be contained in an amount not exceeding the above range and there is no problem in terms of safety.
본 발명의 식품 조성물의 일 예로 건강음료 조성물로 사용될 수 있으며, 이 경우 통상의 음료와 같이 여러 가지 향미제 또는 천연 탄수화물 등을 추가 성분으로 함유할 수 있다. 상술한 천연 탄수화물은 포도당, 과당과 같은 모노사카라이드; 말토스, 슈크로스와 같은 디사카라이드; 덱스트린, 사이클로덱스트린과 같은 폴리사카라이드; 자일리톨, 소르비톨, 에리트리톨 등의 당알콜일 수 있다. 감미제는 타우마틴, 스테비아 추출물과 같은 천연 감미제; 사카린, 아스파르탐과 같은 합성 감미제 등을 사용할 수 있다. 상기 천연 탄수화물의 비율은 본 발명의 건강음료 조성물 100 mL 당 일반적으로 약 0.01 내지 0.04 g, 구체적으로 약 0.02 내지 0.03 g이 될 수 있다.As an example of the food composition of the present invention, it can be used as a health beverage composition. In this case, various flavors or natural carbohydrates can be added as an additional ingredient like ordinary beverages. The above-mentioned natural carbohydrates include monosaccharides such as glucose and fructose; Disaccharides such as maltose, sucrose; Polysaccharides such as dextrin, cyclodextrin; Xylitol, sorbitol, erythritol, and the like. Sweeteners include natural sweeteners such as tau Martin and stevia extract; Synthetic sweetening agents such as saccharin and aspartame, and the like can be used. The ratio of the natural carbohydrate may be generally about 0.01 to 0.04 g, specifically about 0.02 to 0.03 g per 100 mL of the health beverage composition of the present invention.
상기 외에 건강음료 조성물은 여러 가지 영양제, 비타민, 전해질, 풍미제, 착색제, 펙트산, 펙트산의 염, 알긴산, 알긴산의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알코올 또는 탄산화제 등을 함유할 수 있다. 그 밖에 천연 과일주스, 과일주스 음료, 또는 야채 음료의 제조를 위한 과육을 함유할 수 있다. 이러한 성분은 독립적으로 또는 혼합하여 사용할 수 있다. 이러한 첨가제의 비율은 크게 중요하진 않지만 본 발명의 건강음료 조성물 100 중량부당 0.01 내지 0.1 중량부의 범위에서 선택되는 것이 일반적이다.In addition to the above, the health beverage composition may contain various nutrients, vitamins, electrolytes, flavors, colorants, pectic acid, salts of pectic acid, alginic acid, salts of alginic acid, organic acid, protective colloid thickener, pH adjuster, stabilizer, Alcohols or carbonating agents, and the like. It may also contain flesh for the production of natural fruit juices, fruit juice drinks, or vegetable drinks. These components may be used independently or in combination. The proportion of such additives is not critical, but is generally selected in the range of 0.01 to 0.1 parts by weight per 100 parts by weight of the health beverage composition of the present invention.
본 발명의 식품 조성물은 숙취의 예방 또는 개선 효과를 나타낼 수 있다면 다양한 중량%로 포함할 수 있으나, 구체적으로 본 발명의 추출물을 식품 조성물의 총 중량 대비 0.00001 내지 100 중량% 또는 0.01 내지 80 중량%로 포함할 수 있으나, 이에 제한되지 않는다.The food composition of the present invention may be contained at various weight percentages as long as it can exhibit a preventive or ameliorative effect of hangover, but specifically, 0.00001 to 100% by weight or 0.01 to 80% by weight, based on the total weight of the food composition, But are not limited thereto.
본 발명의 조성물에 포함된 콩발아배아 추출물이 혈중 알코올 농도 감소 효과를 나타냄을 확인하였는 바, 숙취를 예방 또는 치료할 수 있는 다양한 형태의 제품개발에 널리 활용될 수 있을 것이다. As a result of confirming that the soybean germinated embryo extract contained in the composition of the present invention exhibits an effect of reducing the blood alcohol concentration, it can be widely used in the development of various types of products capable of preventing or treating hangover.
도 1은 콩 발아배아 추출물(GSG-1)에 의한 혈중 알코올 감소효과를 나타내는 그래프이다.
도 2는 마우스에 에탄올 투여 직후부터 마지막 채혈시점까지의 혈중 알코올의 총량을 정량분석한 결과를 나타내는 그래프이다.FIG. 1 is a graph showing an effect of decreasing alcohol in blood by soybean germinated embryo extract (GSG-1).
FIG. 2 is a graph showing the results of quantitative analysis of the total amount of alcohol in the blood from the time immediately after administration of ethanol to the time of the last blood collection in a mouse.
이하 본 발명을 실시예를 통하여 보다 상세하게 설명한다. 그러나 이들 실시예는 본 발명을 예시적으로 설명하기 위한 것으로 본 발명의 범위가 이들 실시예에 한정되는 것은 아니다.Hereinafter, the present invention will be described in more detail with reference to examples. However, these examples are for illustrative purposes only, and the scope of the present invention is not limited to these examples.
실시예Example 1: 콩 1: beans 발아배아Germination embryo 추출물의 제조 Preparation of extract
콩 발아배아 추출물을 제조하기 위하여 본 발명자의 선행 연구에 따라 제조한 콩 발아배아를 이용하였다. 구체적으로, 콩 배아를 흐르는 물에 침지하여 발아시키고 24시간 정도 경과한 시점에서 콩 발아배아를 수확하여 동결건조 시켰으며, 이를 분말화하여 콩발아배아 분말을 수득하였다. 상기 수득한 콩 발아배아 분말에 발효주정을 가하여 추출하고, 이를 여과하여 액상성분을 수득하고, 상기 액상성분을 동결건조시켜 콩 발아배아 추출물(GSG-1)을 수득하였다. In order to prepare the soybean germinated embryo extract, the soybean germinated embryo prepared according to the previous study of the present inventor was used. Specifically, the soybean embryo was immersed in running water and germinated. After about 24 hours, the soybean germinated embryo was harvested, lyophilized and powdered to obtain a soybean germinated embryo powder. The resulting soybean germinated embryo powder was extracted by adding a fermented syrup, followed by filtration to obtain a liquid component, and the liquid component was freeze-dried to obtain a soybean germinated embryo extract (GSG-1).
실시예Example 2: 콩 2: Soybean 발아배아Germination embryo 추출물의 혈중 알코올 감소효과 분석 Analysis of Blood Alcohol Depletion Effect of Extracts
상기 실시예 1에서 제조된 콩 발아배아 추출물(GSG-1)이 혈중 알코올 감소효과를 나타내는지 확인하였다.It was confirmed that the soybean germinated embryo extract (GSG-1) prepared in Example 1 exhibited a blood alcohol decreasing effect.
구체적으로, 마우스에 30mg/Kg의 용량으로 상기 콩 발아배아 추출물(GSG-1)을 경구투여하고, 30분이 경과된 시점에서 5g/Kg의 용량으로 33%(v/v)의 에탄올을 경구투여하였다. 상기 에탄올을 투여하고, 1, 2, 3 또는 5시간이 경과된 시점에서 안와정맥총에서 혈액을 채취한 다음, 중크로산염 (dichromate) 반응을 이용해 580nm에서 흡광도를 측정하는 정량분석법 (colorimetric determination)통해 상기 채취된 혈액에 포함된 혈중 잔여 알코올 농도를 측정하였다(도 1). 이때, 대조군으로는 콩 발아배아 추출물 대신에 증류수를 경구투여한 마우스를 사용하였다.Specifically, the soybean germinated embryo extract (GSG-1) was orally administered to a mouse at a dose of 30 mg / Kg and 30 minutes later, 33% (v / v) ethanol was orally administered at a dose of 5 g / Kg Respectively. After ethanol was administered, blood was collected from the orbital vein at 1, 2, 3 or 5 hours, and then analyzed by colorimetric determination of absorbance at 580 nm using a dichromate reaction The blood residual alcohol concentration in the collected blood was measured (Fig. 1). As a control group, mice treated with distilled water orally instead of soybean germinated embryo extract were used.
도 1은 콩 발아배아 추출물(GSG-1)에 의한 혈중 알코올 감소효과를 나타내는 그래프이다. FIG. 1 is a graph showing an effect of decreasing alcohol in blood by soybean germinated embryo extract (GSG-1).
도 1에서 보듯이, 에탄올 투여후, 1시간이 경과된 시점까지는 혈중 알코올 농도에 차이가 없었으나, 2시간이 경과된 이후에는 콩 발아배아 추출물(GSG-1)을 투여한 마우스의 혈중 알코올의 수준이 대조군에 비하여 감소됨을 확인하였다. 특히, 에탄올 투여후 1시간이 경과된 시점의 혈중 알코올 농도를 기준으로 할 때, 5시간이 경과된 시점의 혈중 알코올 농도의 변화수준은 약 38%가 감소된 것으로 확인되었다.As shown in FIG. 1, there was no difference in blood alcohol concentration until 1 hour after the ethanol administration, but after 2 hours, the blood alcohol level of the GSG-1-administered mouse Compared with the control group. In particular, it was confirmed that the level of change in blood alcohol concentration was decreased by about 38% when 5 hours had elapsed, based on the blood alcohol concentration at 1 hour after ethanol administration.
또한, 마우스에 에탄올 투여 직후부터 마지막 채혈시점까지의 혈중 알코올의 총량을 혈중농도-시간 곡선하(Area under curve, AUC) 면적을 분석하여 정량분석하였다. 이때, 혈중 알코올의 농도가 증가하는 구간에서는 linear trapezoidal summation을 이용하여 산출하고, 혈중 알코올 농도가 감소하는 구간에서는 log/linear trapezoidal summation을 이용하여 산출하였다(도 2).The total amount of alcohol in the blood from the time immediately after administration of ethanol to the time of the last blood sampling in the mouse was analyzed by analyzing the Area under curve (AUC) area. At this time, linear trapezoidal summation was used for the increase of blood alcohol concentration, and log / linear trapezoidal summation was used for the decrease of blood alcohol concentration (Fig. 2).
도 2는 마우스에 에탄올 투여 직후부터 마지막 채혈시점까지의 혈중 알코올의 총량을 정량분석한 결과를 나타내는 그래프이다.FIG. 2 is a graph showing the results of quantitative analysis of the total amount of alcohol in the blood from the time immediately after administration of ethanol to the time of the last blood sampling in a mouse.
도 2에서 보듯이, 콩 발아배아 추출물(GSG-1)을 투여한 마우스의 혈중 알코올 총량이 대조군에 비하여 약 38% 감소됨을 확인하였다.As shown in FIG. 2, it was confirmed that the total amount of alcohol in the blood of the mouse administered with the soybean germinated embryo extract (GSG-1) was reduced by about 38% as compared with the control.
Claims (7)
A pharmaceutical composition for preventing or treating hangover, comprising a soybean germinated embryo extract or a fraction thereof.
상기 콩 발아배아는 콩으로부터 분리된 배아를 발아시켜 수득하는 것인, 조성물.
The method according to claim 1,
Wherein the soybean germinated embryo is obtained by germinating the embryo isolated from the soybean.
상기 추출물은 물, 탄소수 1 내지 4의 저급 알코올, 또는 이들의 혼합용매로 상기 콩 발아배아를 추출하여 수득하는 것인, 조성물.
The method according to claim 1,
Wherein the extract is obtained by extracting the soybean germinated embryo with water, a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof.
상기 분획물은 물, 탄소수 1 내지 4의 저급 알코올, 비극성 용매, 또는 이들의 혼합용매로 상기 추출물을 분획하여 수득하는 것인, 조성물.
The method according to claim 1,
Wherein the fraction is obtained by fractionating the extract with water, a lower alcohol having 1 to 4 carbon atoms, a non-polar solvent, or a mixed solvent thereof.
상기 조성물은 약학적으로 허용되는 담체, 부형제 또는 희석제를 추가로 포함하는 것인, 조성물.
The method according to claim 1,
Wherein the composition further comprises a pharmaceutically acceptable carrier, excipient or diluent.
A method for preventing or treating hangover, comprising administering the pharmaceutical composition of any one of claims 1 to 5 to a subject other than a human having or at risk of having a hangover symptom.
A food composition for prevention or improvement of hangover, comprising a soybean germinated embryo extract or a fraction thereof.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR100552398B1 (en) * | 2004-08-25 | 2006-02-21 | 박희학 | An alcohol detoxification beverage comprising extract of horse bean |
| KR20150088671A (en) * | 2014-01-24 | 2015-08-03 | 농업회사법인 이조은산소 주식회사 | Hangover recovery drink using bean sprouts and manufacturing method thereof |
| KR101601947B1 (en) * | 2015-06-03 | 2016-03-09 | 주식회사 한생바이오 | Beverage composition for relieving hangover comprising peanut sprouts and manufacturing method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100552398B1 (en) * | 2004-08-25 | 2006-02-21 | 박희학 | An alcohol detoxification beverage comprising extract of horse bean |
| KR20150088671A (en) * | 2014-01-24 | 2015-08-03 | 농업회사법인 이조은산소 주식회사 | Hangover recovery drink using bean sprouts and manufacturing method thereof |
| KR101601947B1 (en) * | 2015-06-03 | 2016-03-09 | 주식회사 한생바이오 | Beverage composition for relieving hangover comprising peanut sprouts and manufacturing method thereof |
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