KR20180107335A - Compositions with the calming effect for sensitive skin using Morus alba root extract - Google Patents

Abstract

The present invention relates to a skin soothing composition. More specifically, provided is a composition which contains a Morus alba root extract, a Morus alba bark extract, and a silkworm cocoon extract, alleviates erythema on skin, and controls level of oil secretion. In addition, the composition shows skin soothing effects and skin sensitivity improving effects by increasing moisture content.

Description

[0001] The present invention relates to a composition for calming skin comprising Morus alba root extract containing mulberry root extract as an active ingredient,

The present invention relates to a skin-soothing composition comprising Morus alba root extract as an active ingredient. More particularly, the present invention relates to a composition for moisturizing, antibacterial and antifungal effect on mulberry root extract, mulberry bark extract and cocoon extract, The present invention relates to a composition for skin soothing that further comprises an effective ingredient for anti-inflammation.

Rapid environmental changes in modern society have a great impact on individual lives and diseases. The concept of sensitive skin is increasing not only the stimulation factors of the human body but also the level of living according to the social development of the general public and the awareness of the general people due to the development of the beauty industry.

Generally, sensitive skin is defined as a skin that exhibits better contact stimulus or allergic response than the average population. Sensitive skin is easily damaged by external stimuli, and skin normalization mechanism is destroyed, resulting in irritation such as erythema, edema, tingling and itching. In addition, sensitive skin easily reveals reactions such as erythema, swelling, tingling, itching, and the like in the ultraviolet rays caused by the destruction of the ozone layer and in the specific substances contained in the skin care products used in everyday use. In recent years, sensitive skin is gradually increasing due to the influence of environmental pollution, lifestyle changes, stress, and the like, and it is becoming a social problem.

Cytokines and inflammatory mediators are involved in the hypersensitivity reactions in sensitive skin. The main chemical transfer mediators that cause the inflammation reaction are amines such as histamine or serotonin, quinines such as bradykinin, prostaglandins, leukotrienes, Cain and others.

Conventionally, in order to prevent the induction of hypersensitivity reaction, only the cosmetic ingredient has been removed from the components which are likely to cause an hypersensitive reaction. However, sensitive skin holders also need to use cosmetics that contain ingredients that are likely to cause irritation, so it is necessary to relieve skin irritation rather than simply not using ingredients that may cause hypersensitivity reactions.

Conventional antiinflammatory agents such as aspirin and indomethacin have widely been recognized as being effective, but side effects such as gastrointestinal disturbance and vasodilatation are known, and antagonists against neuropeptide-based substances including substance P, Antiinflammatory agents such as antagonists and cyclooxygenase inhibitors to ning have limited range and level of use due to legal issues such as human safety, stability problems in the products, restrictions on the use of the products.

In addition, the composition for treatment of sensitive skin proposed in Japanese Laid-Open Patent Publication No. 2006-0058094 (published on May 29, 2006) contains a chemical synthetic substance and a steroid preparation and can show a great effect for a short period of time. However, It is possible to cause side effects such as thinning of the skin.

Published Japanese Patent Application No. 2006-0058094 (published May 29, 2006)

It is an object of the present invention to solve the problems of the prior art, and it is an object of the present invention to provide a composition comprising Morus alba root extract, Morus alba bark extract and Silkworm cocoon extract, It is an object of the present invention to provide a composition for dermatological soothing which shows erythema relief, oil control and moisture increasing effect and can help to calm the skin and improve the sensitivity.

To achieve the above object, the composition for skin soothing of the present invention includes mulberry root extract, mulberry bark extract, and silkworm extract. At this time, the mulberry root extract is stabilized with a nanoliposome having an average diameter of 30 to 70 nm.

In addition, the skin-soothing composition of the present invention may contain 4-10 parts by weight of mulberry root extract, 2-8 parts by weight of extract of Mulberry bark extract, and 2-8 parts by weight of cocoon extract, more preferably, 7: 5: 5 by weight.

The skin-soothing composition of the present invention may further comprise 1 to 5 parts by weight of Biosaccharide Gum-1. BIO NEAT-WS (1,3-Butylene Glycol and Capryl Hydroxamic Acid & 0.1 to 1 part by weight of hexanediol & Boswellia Serrata Resin Extract, 5 to 15 parts by weight of 1.3 BG (Butylene Glycol) and 65 to 75 parts by weight of purified water.

The mulberry root extract, mulberry bark extract, and cocoon extract of the present invention are characterized in that they are extracted by hot water extraction method.

The skin-soothing composition of the present invention is characterized by having a formulation selected from the group consisting of a solution, a suspension, an emulsion, a paste, a gel, a cream, a lotion, a powder, an oil, a powder or a spray.

The skin-soothing composition of the present invention comprises mulberry roots extract, mulberry bark extract, and cocoon extract. By using the above-mentioned natural materials, it is possible to relieve erythema, control oil and increase moisture without side effects such as skin resistance and thinning , Can help to calm skin and improve sensitivity. In addition, BIO NEAT-WS, a natural preservative that is not a commonly used chemical preservative, has the advantage of preserving the preservation function and alleviating the irritation of the skin.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the drawings. Prior to the description, terms and words used in the present specification and claims should not be construed as limited to ordinary or dictionary meanings and should be construed in accordance with the technical concept of the present invention.

Throughout this specification, when an element is referred to as including an element, it is to be understood that the element may include other elements, without departing from the spirit or scope of the present invention.

Each step may be performed differently than the order specified unless explicitly stated in the context of the specific order. That is, each of the steps may be performed in the same order as described, or may be performed substantially concurrently or in the reverse order.

Hereinafter, the composition for dermatological soothing comprising Morus alba root extract as an active ingredient of the present invention will be described in more detail.

The present invention relates to a composition for calming skin comprising mulberry root extract, Morus alba bark extract and silkworm cocoon extract. When the composition is applied to the skin, erythema relief, oil control and moisture The present invention relates to a composition for skin soothing which can help to calm the skin and improve the sensitivity.

In the present specification, mulberry is a deciduous broad-leaved arboreous tree, and its active ingredients include water berlin, water verochromen, Beta -amyrin, sitosterol, sitosterol-d-glucoside, betulinic acid, adenine, betaine, palmitic acid, stearic acid and the like. Mulberry root extract has skin whitening effect (tyrosinase inhibitory effect), wrinkle improving effect (elastase inhibiting effect) and UVB absorption function, and also has skin irritation improving effect by immunity improving.

The mulberry bark is the bark of the mulberry root, and more specifically, the root layer which has removed the cork layer from the root of the mulberry. It is used for inflammation, diuretic, nervous breakdown, insomnia, gray hair and diabetes. It has anti-inflammatory and soothing effects and can treat inflammation caused by skin damage when applied to skin and can alleviate skin irritation.

Silkworm is very sensitive to the cleanliness and pesticides in cultivation, and is widely used as an insect for inspecting the stability. The cocoon extract contains sericin and Fibroin proteins, which exhibit effects such as skin coating effect, moisturizing, antioxidant ability, and skin affinity.

At this time, the silkworm varieties may be used regardless of which kind of silkworms are used, but it is preferable to use silkworm silkworms in which the mulberry leaves of the digestive tissues are completely digested and the false silk is maximally developed in order to construct the silkworm cocoon.

The composition for skin soothing according to the present invention preferably contains 4 to 10 parts by weight of the mulberry root extract, 2 to 8 parts by weight of the extract of Mulberry bark extract, and 2 to 8 parts by weight of the extract of the silkworm culm. The mulberry root extract, It is more preferable that the cocoon extract is contained in a ratio of 7: 5: 5 by weight. When the content of the mulberry extract is less than the above range, the skin soothing effect is low. When the content is higher than the above range, the increase of the effect is insufficient, which is economically undesirable.

As used herein, the term " part by weight " means a weight-based mixing ratio between constituent materials constituting the composition. In other words, in the light of the above-mentioned description, it means that the mulberry root extract, manganese berry extract and cocoon extract are mixed at a weight ratio of 4: 10: 2 to 8: 2: 8.

The present invention relates to a composition for skin cleansing wherein the mulberry root extract is contained in a form stabilized with nanoliposome.

The nanoliposome refers to a liposome having an ordinary liposome form and having an average particle diameter of 1 to 100 nm, and preferably has an average particle diameter of 30 to 70 nm. When the average particle size of the nanoliposome is less than 30 nm, the stability of the formulation is poor. When it exceeds 70 nm, penetration into the skin is difficult.

The present invention relates to 1 to 5 parts by weight of Biosaccharide Gum-1. The biosaccharide gum-1 is a polymeric moisturizer obtained by using a fermentation method. More specifically, biosaccharide gum-1 has a complex polymer structure and is effective for maintaining moisturization of the skin. It forms an aqueous film on the dry skin and exhibits an effect of keeping the skin moist for a long time. When included in the above range Such Moisturizing effect is most effective.

The present invention relates to a composition comprising BIO NEAT-WS (1,3-Butylene Glycol and Capryl Hydroxamic Acid and 1,2-Hexanediol and Boswellia Serrata Resin Extract), 1.3 BG (Butylene Glycol) and purified water ≪ / RTI >

BIO NEAT-WS is a natural preservative. In general, preservatives are substances that prevent the propagation and decay of bacteria and microorganisms, and chemical preservatives such as ethanol, propylparaben, butylparaben, methylparaben, ethylparaben, benzoic acid, imidazolidinyl urea and paraoxybenzoic acid have been used. Such conventional preservatives may irritate the skin and cause side effects such as causing contact dermatitis.

On the other hand, BIO NEAT-WS is a natural paraben-free preservative containing an extract of a moisturizing component having a preservative function. More specifically, it includes 1,3-Butylene Glycol, 1,2 Hexanediol, Caprylohydroxamic Acid (CHA) and Boswellia serrata Resin Extract.

1,3-Butylene Glycol is an amphipathic glycolline that is close to hydrophilic and has very low irritation to the skin. It exhibits antimicrobial properties against microorganisms and gives moisture to the skin. 1,2 Hexanediol is a vegetable glycerin that has excellent antimicrobial activity against fungi when it helps formulation stability. Caprylohydroxamic Acid (CHA) is effective at neutral pH, can prevent fungal growth by chelating effect, and has a surfactant effect. Finally, Boswellia serrata Resin Extract is a component extracted from Indian oriental resin, which has anti-inflammatory function and functions to reduce the burning sensation on the skin contact of polyhydric alcohols.

These BIO NEAT-WS exhibit effective repellency within the product and do not cause irritation or allergy. However, in a state where the component is not completely dissolved in an excessive amount and is not dissolved in the skin, the remaining components may not react with the skin and cause a slight heat sensation while reacting with moisture, so that the component is preferably included in the composition of the present invention in an amount of 0.1 to 1 part by weight .

1.3 BG is a large organic alcohol. A common alcohol quickly evaporates moisture, but the 1.3 EG has a function of attracting moisture and acts as a moisturizer that keeps the moisture of the skin.

Purified water controls the viscosity and specific gravity of the composition and maintains the stability of the formulation. It is preferable that the composition contains 65 to 75 parts by weight of the composition, but it can be adjusted according to the formulation to be prepared.

In the present invention, the mulberry extract, mulberry bark extract, and silkworm cocoate extract are hot water extracts of mulberry, mallow, and cocoon. Each extract is mixed with 5 to 10 L of extract per 1 kg of each composition, Heat for 5 hours to extract hot water.

Generally, when extracting natural products, it is generally extracted with a solvent mixed with a certain amount of purified water or purified water and alcohols. In order to efficiently extract the active ingredients of the natural products, alkaline ionized water having a pH of 7.5 to 10.5 And is used as an extraction water.

Alkali ionized water is composed of 6 units of molecular clusters and is smaller than water which forms hydrogen bonds at 13-15 units. It has good penetration power and high heat conductivity, so that component elution is efficient and absorption power is also excellent. Accordingly, in the present invention, by using alkaline ionized water as a solvent, the active ingredient can be safely extracted, and the original active function can be sufficiently exhibited.

The extracted water of the present invention is preferably a supernatant obtained by adding 100 to 400 g of calcium oxide per 1,000 ml of alkaline ionized water, stirring the mixture, and allowing the mixture to stand at room temperature for 3 to 10 hours. The calcium oxide acts to increase the osmotic pressure of the solvent against the solute, and thus the content of the active ingredient having an antibacterial effect in the extracted solution can be further increased. That is, the alkaline ionized water and calcium oxide may be used together to obtain a synergistic effect of increasing the antibacterial effect.

The composition for dermatoses according to the present invention may have conventional formulations and may be prepared in formulations such as solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, oils or sprays. The composition of each of these formulations may contain various kinds of bases and additives necessary for formulation of the formulation, and the kinds and amounts of these ingredients can be easily selected by those skilled in the art.

The cosmetic composition having a skin soothing effect according to the present invention may be used according to a conventional method of use, and may be used in a number of times depending on the skin condition or taste of the user.

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims and their equivalents. shall.

Preparation of compositions for skin soothing

10 L of alkaline ionized water having a pH of 8 per 1 kg of the composition of each of mulberry root, bark, and cocoon were mixed and heated for 5 hours at 90 캜 for hot water extraction. The natural extracts were prepared by mixing the mulberry root extract, mulberry bark extract, and cocoon extract obtained by hot water extraction in a ratio of 7: 5: 5 by weight. The natural extracts were mixed with biosaccharide-1, BIO NEAT-WS, 1.3 BG and purified water were added. At this time, the content of each composition is the same as in Table 1 (test group).

ingredient Test group Control A Control group B
(under) Control C
(Excess) Mulberry Root Extract 7 - 3.1 10.6 Eucalyptus extract 5 - 5.2 4.8 Cocoon extract 5 - 5.2 4.8 Bai Osaka Ride Gum -1 3 3.6 3.1 2.9 BIO NEAT-WS 0.5 0.6 0.5 0.5 1.3 BG 10 12 10.4 9.6 Purified water 69.5 83.8 72.4 66.8

(Unit: g)

In Table 1, the test group is the composition for dermatological use of the present invention. The control group A is a composition consisting of only the components other than the mulberry root extract, mulberry bark extract, and silkworm extract, which are effective components of the composition of the test group. Therefore, by comparing the test group with the control group A, the effect of improving the skin soothing effect and sensitivity of the active principle can be confirmed.

The control group B and the control group C were prepared by varying the content of the mulberry root extract. The production method except for the content was the same as that of the test group. More specifically, a comparison between the test group and the control group B containing less than 4 parts by weight of the extract of mulberry root extract and the control group C containing more than 10 parts by weight of the skin-soothing composition of the present invention showed a skin soothing effect and a sensitivity improving effect The content of mulberry root extract can be confirmed.

Lactate stool examination

In order to select the subjects to be tested for sensitivities, lactic acid speckle test was performed by primary screening. Before the test, subjects were asked to wash with the same cleanser and after 30 minutes of stabilization, steam was applied to the face for 10 minutes to open the pores. Then 50 μl of 10% lactic acid solution was dropped on a 2 cm diameter Hilltop chamber absorption band and attached to both sides of the malar eminence of the patient. The subject's self-inferiority was graded from 0 to 3 (0: none, 1: weak, 2: moderate, 3: severe).

At this time, the sensitive skin was limited to the subjects who felt irritability of grade 2 or above for the above 5 minutes, and 40 persons in the last 20s and 30s were selected for the skin sensitivity evaluation test.

Evaluation of skin sedation and sensitivity improvement

Test groups and control groups A to C were prepared according to Example 1 and applied to 40 test subjects selected in Example 2. Ten test group, 10 control group A, 10 control group B, and control group C 10 patients were randomly assigned to use for 4 weeks each.

Skin erythema, oil and moisture were measured before and 4 weeks after the use of the test group and the control groups A to C, respectively, in order to evaluate the effect of the skin soothing composition of the present invention on improving skin soothing and sensitivity. 2.

Skin erythema was measured using a colorimeter (Chromameter CR-300, Minolta, Japan). When skin tone is measured by a color difference meter, it is represented by L * a * b * three dimensions. Erythema is evaluated by a * value which is a value between a passive value and a negative value. The higher the a * value, the more severe the skin erythema.

Skin fat content was measured in a T zone for 25 seconds using a sebum analyzer (Sebumeter SM810, C + K Electronic Co., Germany). The higher the value, the higher the skin oil content.

Skin moisture was measured three times by using a moisture meter (Corneometer CM820, C + K Electronic Co., Germany) and the mean value was used. The higher the value, the higher the skin moisture content.

Test group Control A Control group B Control C Before use Four weeks Rate of change
(%) Before use Four weeks Rate of change
(%) Before use Four weeks Rate of change
(%) Before use Four weeks Rate of change
(%) Erythema
(a *) 15.36 14.69 4.36 15.62 15.21 2.62 14.97 14.53 2.94 15.27 14.63 4.19 Oil
(占 퐂 / cm2h) 102.3 75.3 26.4 103.5 78.2 24.4 101.1 74.9 25.9 104.7 75.8 27.6 moisture
(AU) 23.2 40.8 75.9 22.8 36.5 60.1 25.6 42.2 64.8 24.1 38.9 61.4

According to the above Table 2, the erythema, oil and water change rates of the test group were 4.36%, 26.4% and 75.9%, respectively, and that of the control group A was 2.62%, 24.4% and 60.1% It was confirmed that the improvement rate of erythema, oil and moisture was higher.

In the control group B, the erythema, oil and water change rates were 2.94%, 25.9% and 64.8%, respectively. As compared with the control group A, which had no effective active ingredient, the erythema, In comparison, all three items showed low improvement rate.

On the other hand, in the case of control C, erythema, oil and water change rates were 4.19%, 27.6% and 61.4%, respectively, indicating that erythema, oil and water were improved compared to control group A, Compared with the control group, it showed lower rate of erythema and moisture except oil.

The results of the experiments of Examples 1 to 3 above show that the composition for skin cleansing comprising the mulberry root extract, mulberry bark extract, and silkworm extract of the present invention is effective in improving skin erythema, oil and moisture, It can be seen that it is effective for improvement.

In particular, it was found that the active principle was effective in improving skin soothing and sensitivity through comparison of the test group and the composition excluding the effective main component, mulberry root extract, mulberry bark extract and silkworm extract (control group A).

Also, a comparison between the test group and the control groups B to C shows that when the content of mulberry root extract is smaller than that of the present invention, the effect of improving skin sedimentation and sensitivity is poor, and even when a large amount of mulberry root extract is contained, But not increase.

Therefore, when the composition for skin soothing that contains the mulberry root extract, mulberry bark extract, and cocoon extract is used, the erythema of the skin is alleviated, the amount of oily secretion is controlled, the moisture content is increased, And skin sensitivity can be improved.

Claims (9)

Morus alba root extract, Morus alba bark extract, and Silkworm cocoon extract. The method according to claim 1,
Wherein the mulberry root extract is stabilized with a nanoliposome. 3. The method of claim 2,
Wherein the nanoliposome has an average diameter of 30 to 70 nm. The method according to claim 1,
Wherein the skin-soothing composition comprises 4 to 10 parts by weight of the mulberry root extract, 2 to 8 parts by weight of an extract of Mulberry bark extract, and 2 to 8 parts by weight of a cocoon extract. 5. The method of claim 4,
Wherein the mulberry root extract, mulberry bark extract, and cocoon extract are mixed at a weight ratio of 7: 5: 5. 5. The method of claim 4,
Wherein the composition for skin soothing further comprises 1 to 5 parts by weight of Biosaccharide Gum-1. 5. The method of claim 4,
The skin-soothing composition may contain 0.1 to 1 parts by weight of BIO NEAT-WS (1,3-Butylene Glycol and Capryl hydroxamic acid and 1,2-hexanediol and Boswellia serrata resin extract), 5 to 15 parts by weight of 1.3 BG (Butylene Glycol) , And purified water 65 to 75 parts by weight. The method according to claim 1,
Wherein the mulberry root extract, mulberry bark extract, and cocoon extract are extracted by hot water extraction method. 9. The method according to any one of claims 1 to 8,
Wherein the composition has a formulation selected from the group consisting of solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, oils or sprays.