KR20180102328A - 교모세포종의 진단 또는 예후 예측용 바이오마커 및 그 용도 - Google Patents
교모세포종의 진단 또는 예후 예측용 바이오마커 및 그 용도 Download PDFInfo
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Abstract
본 발명은 교모세포종의 진단 또는 예후 예측용 바이오마커 및 그 용도에 관한 것으로, 더욱 자세하게는 교모세포종 진단 또는 예후 예측에 유용한 105개 바이오마커에 관한 것이다. 본 발명에서 개발한 중간엽 교모세포종으로의 분화와 관련 있는 MES-TAM signature는 교모세포종 재발시 예후를 예측할 수 있으므로, 발굴된 MES-TAM signature를 대상으로 새로운 개념의 표적 치료 및 항암제 개발에 응용될 수 있어 유용하다.
Description
본 발명은 교모세포종의 진단 또는 예후 예측용 바이오마커 및 그 용도에 관한 것으로, 더욱 자세하게는 교모세포종 진단 또는 예후 예측에 유용한 105개 바이오마커에 관한 것이다.
신경교종 (glioma)은 원발성 뇌종양 (primary brain tumor)의 60%를 차지하는 종양으로 현재까지도 방사선 치료 외엔 특별한 치료법이 없는 악성 종양이다. 특히 가장 악성으로 분류되는 교모세포종 (glioblastoma)은 다른 암과 비교하여 방사선 및 항암제 치료에 대한 저항성이 매우 높아 일단 진단되면 기대 생존기간이 1년에 불과하다. 악성 교모세포종은 전체 뇌종양의 12~15%를 차지하고, 뇌 교종의 50~60%를 차지하는 뇌에 발생하는 단일 종양 중 가장 많이 발생하는 종양이다. 또한, 뇌혈관 장벽이 있어 약물의 전달이 쉽지 않고, 상대적으로 뇌신경 생물학에 대한 이해의 부족 때문에 치료제 개발에서 소외된 분야이기도 하다.
교모세포종 (Glioblastoma multiforme, GBM)에서 중간엽 서브타입 (Mesenchymal subtype)으로의 분화는 종양형성능을 촉진시켜 다른 서브타입에 비해 확연한 환자 예후 불량을 보인다 (Phillips, H.S., et al., Cancer cell 9:157-173, 2006; Verhaak, R.G., et al., Cancer cell 17:98-110, 2010). 중간엽 (MES) 표현형으로의 이동으로 인해 종양의 공격성이 강해져 재발시 예후가 좋지 않으며, 이러한 중간엽 교모세포종 (Mesenchymal GBM)으로의 분화 과정에서 종양 관련 대식세포 (Tumor-Associated Macrophage; TAM)의 침습이 증가되어 있다.
종양 부위로 모이는 여러 면역 세포들 중에서 특히 대식세포는 암 발달 전 과정에서 풍부하게 나타나는 세포로, 임상 연구에서 대식세포는 일반적으로 암을 촉진하는 것으로 알려져 있다. 원발성 종양 (Primary tumor)에서, 대식세포는 종양의 혈관 신생 자극, 암세포의 침윤, 이동능 및 혈관 내 침윤을 증가시킨다. 전이과정에서 대식세포는 전이 부위를 준비시키고, 암세포의 혈관 외 탈출, 생존 및 지속적인 성장을 촉진한다. 또한, 대식세포는 암의 진행 과정이나 항암 치료 이후의 회복 과정에서 암 면역 억제의 역할과 동시에 방사선치료에 대한 저항성 획득 및 암 침윤 능력, 암 줄기형성능 그리고 신생혈관생성 촉진을 유도한다. 따라서, 암 촉진 역활을 하는 TAM은 암 치료에서 매력적인 표적이 될 수 있다.
그동안 교모세포종에서 TAM을 제거하거나 암 면역억제에 대한 성질을 변환시키기 위한 특정 유전자를 타깃으로 한 연구들이 진행되어 왔지만, 중간엽 교모세포종에서 종양형성능과 연관된 특정 TAM 유전자를 치료 타깃으로 할 수 있는 분자 마커 (molecular marker)들은 알려진 바가 없다.
이에, 본 발명자들은 환자의 종양조직에서 TAM을 직접 분리 후 유전적 분석을 통하여 실제 중간엽 교모세포종 분화 유도와 관련된 105개 MES TAM-specific signature 유전자를 발굴하고, 이를 원발암-재발암 교모세포종 모델 분석 및 TCGA 데이터에 적용한 결과, 이들 유전자가 환자의 예후 불량과 상관관계가 있음을 확인하고, 본 발명을 완성하게 되었다.
본 발명의 목적은 서열번호 1 내지 105로 구성된 군에서 선택되는 어느 하나 이상의 염기서열로 표시되는 유전자를 포함하는 교모세포종의 진단 또는 예후 예측용 바이오마커를 발굴하고, 상기 바이오마커 유전자의 mRNA 또는 상기 유전자가 코딩하는 단백질의 발현 수준을 측정할 수 있는 제제를 포함하는 교모세포종의 진단 또는 예후 예측용 조성물 및 상기 조성물을 포함하는 교모세포종의 진단 또는 예후 예측용 키트를 제공하는데 있다.
본 발명의 다른 목적은 상기 바이오마커 유전자의 발현 수준 또는 상기 유전자가 코딩하는 단백질의 발현 수준을 측정하고, 비교하는 단계를 포함하는 교모세포종의 진단 또는 예후의 예측을 위한 정보제공 방법을 제공하는데 있다.
상기 목적을 달성하기 위하여, 본 발명은 서열번호 1 내지 105로 구성된 군에서 선택되는 어느 하나 이상의 염기서열로 표시되는 유전자의 mRNA 또는 상기 유전자가 코딩하는 단백질 발현 수준을 측정할 수 있는 제제를 포함하는 교모세포종의 진단 또는 예후 예측용 조성물을 제공한다.
본 발명은 또한, 상기 조성물을 포함하는 교모세포종의 진단 또는 예후 예측용 키트를 제공한다.
본 발명은 또한, (a) 환자의 시료로부터 서열번호 1 내지 105로 구성된 군에서 선택되는 어느 하나 이상의 염기서열로 표시되는 유전자의 발현 수준 또는 상기 유전자가 코딩하는 단백질의 발현 수준을 측정하는 단계; 및 (b) 상기 측정된 유전자의 발현 수준 또는 상기 유전자가 코딩하는 단백질의 발현 수준을 대조군 시료와 비교하는 단계를 포함하는 교모세포종의 진단 또는 예후의 예측을 위한 정보제공 방법을 제공한다.
본 발명에서 개발한 중간엽 교모세포종으로의 분화와 관련 있는 MES-TAM signature는 교모세포종 재발시 예후를 예측할 수 있으므로, 발굴된 MES-TAM signature를 대상으로 새로운 개념의 표적 치료 및 항암제 개발에 응용될 수 있어 유용하다.
도 1은 48 case 교모세포종 환자들의 원발암 - 재발암 모델 분석에서 중간엽 교모세포종 (Mesenchymal GBM)으로의 재발 시 환자 예후를 분석한 결과이다.
도 2은 환자의 교모세포종 (GBM) 조직에서의 분리한 종양 관련 대식세포 (TAM)과 나머지 세포군의 분리 및 RNA sequencing 분석 과정, 이 후 105개 유전자로 구성된 MES-TAM 특이 signature의 발굴 과정을 나타낸 모식도이다.
도 3는 MES-TAM signature를 TCGA 교모세포종 (GBM) 데이터에 적용하여 환자 예후를 검증한 결과이다.
도 4는 TCGA microarray dataset (U133A)에서 정상 조직에 비해 IDH1 돌연변이가 없는 일차 교모세포종에서 105개 유전자 MES-TAM 특이 signature의 메타유전자 스코어가 높음을 검증한 결과 (좌) 및 GSE16011 microarray dataset (U133)에서 정상 조직 또는 Grade I, II, II에 비해 GBM에 해당하는 Grade IV에서 MES-TAM 특이 signature의 메타유전자 스코어가 높음을 검증한 결과 (우)이다.
도 5은 MES-TAM signature의 예후를 TCGA microarray dataset (U133A)에서 모든 IDH1 돌연변이가 없는 일차 교모세포종 환자 352명에서 검증한 것 (좌), 352명 중 항암화학요법을 받은 환자 142명에서 검증한 것 (중앙) 및 352명 중 TCGA RNA sequencing dataset 139명에서 검증한 결과 (우)이다.
도 6은 GSE16011 microarray dataset (U133)의 IDH1 돌연변이가 없는 일차 교모세포종 환자 92명에서 방사선 치료를 받은 환자군 (66명)과 방사선 치료를 받지 않은 환자군 (26명)에서 MES-TAM signature의 예후를 재분석한 결과이다.
도 7은 48쌍의 IDH1 돌연변이가 없는 일차 교모세포종 종단 (longitudinal) 샘플의 RNA sequencing 결과에서 유전자 발현의 변화량 (Δ)을 구하여, 계층적 클러스터링(hierarchical clustering)한 결과이다.
도 8는 GSEA 분석을 통해 105개 유전자 MES-TAM 특이 signature가 NM to M 그룹에서는 재발 샘플에서, M to NM 그룹에서는 원발 (primary) 샘플에서 높게 나타나는 것을 확인한 결과이다.
도 2은 환자의 교모세포종 (GBM) 조직에서의 분리한 종양 관련 대식세포 (TAM)과 나머지 세포군의 분리 및 RNA sequencing 분석 과정, 이 후 105개 유전자로 구성된 MES-TAM 특이 signature의 발굴 과정을 나타낸 모식도이다.
도 3는 MES-TAM signature를 TCGA 교모세포종 (GBM) 데이터에 적용하여 환자 예후를 검증한 결과이다.
도 4는 TCGA microarray dataset (U133A)에서 정상 조직에 비해 IDH1 돌연변이가 없는 일차 교모세포종에서 105개 유전자 MES-TAM 특이 signature의 메타유전자 스코어가 높음을 검증한 결과 (좌) 및 GSE16011 microarray dataset (U133)에서 정상 조직 또는 Grade I, II, II에 비해 GBM에 해당하는 Grade IV에서 MES-TAM 특이 signature의 메타유전자 스코어가 높음을 검증한 결과 (우)이다.
도 5은 MES-TAM signature의 예후를 TCGA microarray dataset (U133A)에서 모든 IDH1 돌연변이가 없는 일차 교모세포종 환자 352명에서 검증한 것 (좌), 352명 중 항암화학요법을 받은 환자 142명에서 검증한 것 (중앙) 및 352명 중 TCGA RNA sequencing dataset 139명에서 검증한 결과 (우)이다.
도 6은 GSE16011 microarray dataset (U133)의 IDH1 돌연변이가 없는 일차 교모세포종 환자 92명에서 방사선 치료를 받은 환자군 (66명)과 방사선 치료를 받지 않은 환자군 (26명)에서 MES-TAM signature의 예후를 재분석한 결과이다.
도 7은 48쌍의 IDH1 돌연변이가 없는 일차 교모세포종 종단 (longitudinal) 샘플의 RNA sequencing 결과에서 유전자 발현의 변화량 (Δ)을 구하여, 계층적 클러스터링(hierarchical clustering)한 결과이다.
도 8는 GSEA 분석을 통해 105개 유전자 MES-TAM 특이 signature가 NM to M 그룹에서는 재발 샘플에서, M to NM 그룹에서는 원발 (primary) 샘플에서 높게 나타나는 것을 확인한 결과이다.
다른 식으로 정의되지 않는 한, 본 명세서에서 사용된 모든 기술적 및 과학적 용어들은 본 발명이 속하는 기술분야에서 숙련된 전문가에 의해서 통상적으로 이해되는 것과 동일한 의미를 갖는다. 일반적으로 본 명세서에서 사용된 명명법은 본 기술분야에서 잘 알려져 있고 통상적으로 사용되는 것이다.
본 발명에서는 교모세포종 (GBM) 환자에서 중간엽 교모세포종 및 비중간엽 교모세포종을 기준으로 4가지 환자그룹으로 나누어 예후 및 종양 관련 대식세포 (TAM)의 침습을 분석하여, 중간엽 교모세포종으로 분화하여 재발시 예후도 불량하며 TAM의 침습이 증가한 것을 확인하였다. 이에, 9명의 교모세포종 환자에서 분리한 종양 관련 대식세포 (TAM) 제외 세포군 (TAM-depleted fraction)의 중간엽 메타진스코어와 양의 상관관계를 보이는 종양 관련 대식세포 (TAM) 발현 유전자를 선별하여 1차적으로 614개 유전자를 발굴하였다. 이 후 종양 세포에서는 발현되지 않고 종양 관련 대식세포 (TAM)에서만 특이적으로 발현되는 유전자로의 1차 선별을 위해, 12 종의 교모세포종 환자 유래 이종모델에서 종양 세포에서도 높게 발현되는 유전자를 제외함으로써 최종적으로 105개의 유전자로 구성된 MES TAM specific-signature를 최종 발굴하였다 (표 1).
서열번호 | 유전자표기 | 유전자명칭 | 위치 | Genbank Accession No. | NCBI GI |
1 | MARCO | macrophage receptor with collagenous structure | 2q14.2 | NM_006770 | 56237031 |
2 | CD180 | CD180 molecule | 5q12.3 | NM_005582 | 167555126 |
3 | MMP8 | matrix metallopeptidase 8 | 11q22.2 | NM_002424 | 189571606 |
4 | CR1 | complement C3b/C4b receptor 1 (Knops blood group) | 1q32.2 | NM_000573 | 86793035 |
5 | GPR18 | G protein-coupled receptor 18 | 13q32.3 | NM_005292 | 148227403 |
6 | KYNU | kynureninase | 2q22.2 | NM_003937 | 74101435 |
7 | PPARG | peroxisome proliferator activated receptor gamma | 3p25.2 | NM_005037 | 116284367 |
8 | S100A8 | S100 calcium binding protein A8 | 1q21.3 | NM_002964 | 315221156 |
9 | FPR3 | formyl peptide receptor 3 | 19q13.41 | NM_002030 | 960139370 |
10 | LILRB3 | leukocyte immunoglobulin like receptor B3 | 19q13.42 | NM_006864 | 574269961 |
11 | LOC100128993 | LOC100128993 | 8p22-p21.3 | NR_038919 | 336594700 |
12 | PHACTR2 | phosphatase and actin regulator 2 | 6q24.2 | NM_014721 | 154354973 |
13 | AREG | amphiregulin | 4q13.3 | NM_001657 | 609878452 |
14 | CCL7 | C-C motif chemokine ligand 7 | 17q12 | NM_006273 | 428673540 |
15 | FPR2 | formyl peptide receptor 2 | 19q13.41 | NM_001005738 | 54112387 |
16 | HCAR3 | hydroxycarboxylic acid receptor 3 | 12q24.31 | NM_006018 | 157738693 |
17 | HTRA4 | HtrA serine peptidase 4 | 8p11.22 | NM_153692 | 209977115 |
18 | LILRA5 | leukocyte immunoglobulin like receptor A5 | 19q13.42 | NM_021250 | 542133072 |
19 | MAPK13 | mitogen-activated protein kinase 13 | 6p21.31 | NM_002754 | 393662586 |
20 | ARL11 | ADP ribosylation factor like GTPase 11 | 13q14.2 | NM_138450 | 296040483 |
21 | CATSPER1 | cation channel sperm associated 1 | 11q13.1 | NM_053054 | 221316608 |
22 | CD72 | CD72 molecule | 9p13.3 | NM_001782 | 194018444 |
23 | TNFSF15 | tumor necrosis factor superfamily member 15 | 9q32 | NM_005118 | 324072721 |
24 | ANPEP | alanyl aminopeptidase, membrane | 15q26.1 | NM_001150 | 157266299 |
25 | C19orf59 | mast cell expressed membrane protein 1 | 19p13.2 | NM_174918 | 109698610 |
26 | CEACAM4 | carcinoembryonic antigen related cell adhesion molecule 4 | 19q13.2 | NM_001817 | 574956982 |
27 | DPEP2 | dipeptidase 2 | 16q22.1 | NM_022355 | 385862229 |
28 | IL10 | interleukin 10 | 1q32.1 | NM_000572 | 24430216 |
29 | RBP4 | retinol binding protein 4 | 10q23.33 | NM_006744 | 55743121 |
30 | SLC37A2 | solute carrier family 37 member 2 | 11q24.2 | NM_198277 | 223717976 |
31 | SLC46A2 | solute carrier family 46 member 2 | 9q32 | NM_033051 | 223029453 |
32 | VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor | 12q13.11 | NM_001017535 | 63054844 |
33 | VSIG4 | V-set and immunoglobulin domain containing 4 | Xq12 | NM_007268 | 154426251 |
34 | CD163 | CD163 molecule | 12p13.31 | NM_004244 | 344179109 |
35 | CDA | cytidine deaminase | 1p36.12 | NM_001785 | 80861461 |
36 | CXCL1 | C-X-C motif chemokine ligand 1 | 4q13.3 | NM_001511 | 373432598 |
37 | FBP1 | fructose-bisphosphatase 1 | 9q22.32 | NM_000507 | 160298191 |
38 | MS4A4A | membrane spanning 4-domains A4A | 11q12.2 | NM_024021 | 343098440 |
39 | SLAMF8 | SLAM family member 8 | 1q23.2 | NM_020125 | 149999609 |
40 | ACRBP | acrosin binding protein | 12p13.31 | NM_032489 | 17999523 |
41 | CLEC1A | C-type lectin domain family 1 member A | 12p13.2 | NM_016511 | 663071157 |
42 | F13A1 | coagulation factor XIII A chain | 6p25.1 | NM_000129 | 119395708 |
43 | HEXA-AS1 | HEXA antisense RNA 1 | 15q23 | NR_027262 | 224586810 |
44 | LOC100506229 | LOC100506229 | 4q35.1 | NR_039975 | 337756394 |
45 | MS4A6A | membrane spanning 4-domains A6A | 11q12.2 | NM_152851 | 351721051 |
46 | PSMD6-AS2 | PSMD6 antisense RNA 2 | 3p14.1 | NR_038286 | 333944057 |
47 | SAA1 | serum amyloid A1 | 11p15.1 | NM_199161 | 992319626 |
48 | PPBP | pro-platelet basic protein | 4q13.3 | NM_002704 | 296080750 |
49 | C11orf45 | chromosome 11 open reading frame 45 | 11q24.3 | NM_145013 | 367145069 |
50 | GK3P | glycerol kinase 3 pseudogene | 4q32.3 | NR_026575 | 219803770 |
51 | HLA-DPB2 | major histocompatibility complex, class II, DP beta 2 (pseudogene) | 6p21.32 | NR_001435 | 1077231791 |
52 | IRG1 | aconitate decarboxylase 1 | 13q22.3 | NM_001258406 | 385719223 |
53 | KMO | kynurenine 3-monooxygenase | 1q43 | NM_003679 | 353523858 |
54 | LAIR1 | leukocyte associated immunoglobulin like receptor 1 | 19q13.42 | NM_002287 | 612407858 |
55 | OTOA | otoancorin | 16p12.2 | NM_144672 | 77404408 |
56 | PECAM1 | platelet and endothelial cell adhesion molecule 1 | 17q23.3 | NM_000442 | 313760623 |
57 | TEC | tec protein tyrosine kinase | 4p12-p11 | NM_003215 | 130977758 |
58 | TLR8 | toll like receptor 8 | Xp22.2 | NM_138636 | 574956973 |
59 | TFPI2 | tissue factor pathway inhibitor 2 | 7q21.3 | NM_006528 | 401871057 |
60 | ANXA3 | annexin A3 | 4q21.21 | NM_005139 | 96304463 |
61 | CD84 | CD84 molecule | 1q23.3 | NM_003874 | 296434282 |
62 | CST6 | cystatin E/M | 11q13.1 | NM_000100 | 371502129 |
63 | DNAJC5B | DnaJ heat shock protein family (Hsp40) member C5 beta | 8q13.1 | NM_033105 | 90704849 |
64 | IL7R | interleukin 7 receptor | 5p13.2 | NM_002185 | 391224479 |
65 | SIGLEC9 | sialic acid binding Ig like lectin 9 | 19q13.3-q13.4 | NM_014441 | 310616713 |
66 | SUCNR1 | succinate receptor 1 | 3q25.1 | NM_033050 | 1024336733 |
67 | TREM1 | triggering receptor expressed on myeloid cells 1 | 6p21.1 | NM_018643 | 1017029557 |
68 | CD300C | CD300c molecule | 17q25.1 | NM_006678 | 425905329 |
69 | CLEC12A | C-type lectin domain family 12 member A | 12p13.31 | NM_138337 | 189181662 |
70 | LILRA6 | leukocyte immunoglobulin like receptor A6 | 19q13.42 | NM_024318 | 530788319 |
71 | LYVE1 | lymphatic vessel endothelial hyaluronan receptor 1 | 11p15.4 | NM_006691 | 151301201 |
72 | PLEK2 | pleckstrin 2 | 14q23.3-q24.1 | NM_016445 | 961513293 |
73 | TNFSF8 | tumor necrosis factor superfamily member 8 | 9q32-q33.1 | NM_001244 | 356582493 |
74 | ANKRD34B | ankyrin repeat domain 34B | 5q14.1 | NM_001004441 | 257467558 |
75 | CRTAM | cytotoxic and regulatory T-cell molecule | 11q24.1 | NM_019604 | 755571556 |
76 | IBSP | integrin binding sialoprotein | 4q22.1 | NM_004967 | 167466186 |
77 | PKD2L1 | polycystin 2 like 1, transient receptor potential cation channel | 10q24.31 | NM_016112 | 33598943 |
78 | TRPV4 | transient receptor potential cation channel subfamily V member 4 | 12q24.11 | NM_021625 | 294459961 |
79 | ALOX15B | arachidonate 15-lipoxygenase, type B | 17p13.1 | NM_001141 | 85067500 |
80 | CCL8 | C-C motif chemokine ligand 8 | 17q12 | NM_005623 | 22538815 |
81 | LRG1 | leucine rich alpha-2-glycoprotein 1 | 19p13.3 | NM_052972 | 49574519 |
82 | MMP19 | matrix metallopeptidase 19 | 12q14 | NM_002429 | 442535502 |
83 | SNORD12C | small nucleolar RNA, C/D box 12C | 20q13.13 | NR_002433 | 161169048 |
84 | MIR3945 | microRNA 3945 | 4 | NR_037510 | 312147120 |
85 | ADTRP | androgen dependent TFPI regulating protein | 6p24.1 | NM_032744 | 221139832 |
86 | CCL23 | C-C motif chemokine ligand 23 | 17q12 | NM_005064 | 632794828 |
87 | CYTIP | cytohesin 1 interacting protein | 2q24.1 | NM_004288 | 197100477 |
88 | GMFG | glia maturation factor gamma | 19q13.2 | NM_004877 | 666335605 |
89 | HK3 | hexokinase 3 | 5q35.2 | NM_032410 | 209976984 |
90 | KCNJ15 | potassium voltage-gated channel subfamily J member 15 | 21q22.13-q22.2 | NM_002243 | 449310805 |
91 | LOC100506585 | LOC100506585 | 7q36.3 | NR_038966 | 337298412 |
92 | MRC1 | mannose receptor, C type 1 | 10p12.33 | NM_002438 | 471270251 |
93 | SIGLEC1 | sialic acid binding Ig like lectin 1 | 20p13 | NM_023068 | 89142743 |
94 | SIGLEC7 | sialic acid binding Ig like lectin 7 | 19q13.41 | NM_016543 | 469469049 |
95 | LINC00460 | long intergenic non-protein coding RNA 460 | 13q33.2 | NR_034119 | 300796405 |
96 | CEACAM21 | carcinoembryonic antigen related cell adhesion molecule 21 | 19q13.2 | NM_033543 | 588282733 |
97 | HCAR2 | hydroxycarboxylic acid receptor 2 | 12q24.31 | NM_177551 | 41152145 |
98 | HRH2 | histamine receptor H2 | 5q35.2 | NM_001358 | 68509925 |
99 | IL1RN | interleukin 1 receptor antagonist | 2q14.1 | NM_173841 | 296010856 |
100 | LXN | latexin | 3q25.32 | NM_020169 | 194473713 |
101 | S100A12 | S100 calcium binding protein A12 | 1q21.3 | NM_005621 | 5032058 |
102 | SLAMF9 | SLAM family member 9 | 1q23.2 | NM_033438 | 226342989 |
103 | SIGLEC14 | sialic acid binding Ig like lectin 14 | 19q13.41 | NM_001098612 | 148762979 |
104 | MS4A6E | membrane spanning 4-domains A6E | 11q12 | NM_139249 | 23110998 |
105 | LINC00278 | long intergenic non-protein coding RNA 278 | Yp11.31 | NR_046502 | 387527995 |
따라서, 본 발명은 일 관점에서 서열번호 1 내지 105로 구성된 군에서 선택되는 어느 하나 이상의 염기서열로 표시되는 유전자의 mRNA 또는 상기 유전자가 코딩하는 단백질의 발현 수준을 측정할 수 있는 제제를 포함하는 교모세포종의 진단 또는 예후 예측용 조성물에 관한 것이다.
본 발명에 있어서, 상기 유전자는 MARCO, CD180, MMP8, CR1 또는 GPR18인 것이 바람직하나, 이에 한정되는 것은 아니다.
본 발명에 있어서, 용어 "마커"는 생물학적 현상의 존재와 정량적 또는 정성적으로 연관된 분자를 의미하며, 본 발명의 교모세포종의 진단 또는 예후 예측용 바이오마커는 교모세포종 발병 이후 예후가 양호하거나 불량한 환자를 예측해내는 기준이 되는 유전자를 지칭한다.
본 발명에 있어서, 용어 "예후"는 의학적 귀추(예컨대, 장기 생존 가능성, 무병생존율 등)에 대한 예상을 의미하며, 양성적 예후(긍정적 예후) 또는 음성적 예후(부정적 예후)를 포함하며, 상기 음성적 예후는 재발, 종양 성장, 전이, 약 저항성 등의 병의 진행 또는 치명성(mortality)을 포함하고, 양성적 예후는 질병이 없는 상태 등의 질병의 차도, 종양 퇴행 등의 질병의 개선 또는 안정화(stabilization)를 포함한다.
본 발명에 있어서, 용어 "예측"은 의학적 귀추에 대하여 미리 헤아려 짐작하는 것을 의미하며, 본 발명의 목적상 암으로 진단받은 환자의 병의 경과(병의 진행, 개선, 위암의 재발, 종양 성장, 약 저항성)를 미리 짐작하는 것을 의미한다.
본 발명에 있어서, 상기 유전자 mRNA의 발현 수준을 측정하는 제제는 서열번호 1 내지 105로 구성된 군에서 선택되는 어느 하나 이상의 염기서열로 표시되는 유전자를 증폭할 수 있는 프라이머인 것을 특징으로 할 수 있다.
본 발명에서 용어, "상기 유전자 mRNA의 발현수준을 측정하는 제제" 란 본 발명의 마커 유전자 또는 이들 유전자에 의해 코딩된 단백질의 발현수준을 확인하기 위하여 사용될 수 있는 분자를 의미하며, 바람직하게는 상기 마커에 특이적인 항체, 프라이머 또는 프로브일 수 있다.
본 발명에서 용어, "프라이머"는 짧은 자유 3 말단 수산화기(free 3` hydroxyl group)을 가지는 핵산 서열로 상보적인 주형(template)와 염기쌍(base pair)을 형성할 수 있고 주형의 복사를 위한 시작지점으로는 기능을 하는 짧은 핵산 서열을 의미한다. 본 발명에서는 본 발명 마커 폴리뉴클레오티드의 센스 및 안티센스 프라이머를 이용하여 PCR 증폭을 실시하여 원하는 생성물의 생성 여부를 통해 위암의 예후를 예측할 수 있다. PCR 조건, 센스 및 안티센스 프라이머의 길이는 당업계에 공지된 것을 기초로 변형할 수 있다.
본 발명에서 "프라이머"는 서열번호 1 내지 105로 구성된 군에서 선택되는 어느 하나 이상의 염기서열로 표시되는 유전자의 mRNA에 특이적으로 결합하는 PCR 프라이머이며, 이를 이용한 RT-PCR 또는 정량적 RT-PCR 등을 수행하여 상기 유전자의 발현량을 정상군과 비교함으로써 교모세포종의 진단 또는 예후를 예측할 수 있다.
본 발명에 있어서, 상기 유전자 mRNA의 발현 수준을 측정하는 제제는 서열번호 1 내지 105로 구성된 군에서 선택되는 어느 하나 이상의 염기서열로 표시되는 유전자에 특이적으로 결합하는 프로브인 것을 특징으로 할 수 있다.
본 발명의 "프로브"란 mRNA와 특이적 결합을 이룰 수 있는 짧게는 수 염기 내지 길게는 수백 염기에 해당하는 RNA 또는 DNA 등의 핵산 단편을 의미하며, 라벨링되어 있어서 특정 mRNA의 존재 유무를 확인할 수 있다. 프로브는 올리고뉴클레오티드 프로브, 단쇄 DNA(single straned DNA) 프로브, 이중쇄 DNA (double stranded DNA) 프로브, RNA 프로브 등의 형태로 제작될 수 있다.
본 발명에서는 서열번호 1 내지 105로 구성된 군에서 선택되는 어느 하나 이상의 염기서열로 표시되는 유전자와 특이적으로 결합하여 이들을 인지할 수 있는 핵산 프로브 등을 포괄적으로 포함하는 개념이며, 이를 이용하여 노던 블롯 분석 등을 수행하여 상기 유전자의 발현량을 정상군과 비교함으로써 교모세포종의 진단 또는 예후를 예측할 수 있다.
본 발명에 있어서, 상기 단백질의 발현 수준을 측정하는 제제는 서열번호 1 내지 105로 구성된 군에서 선택되는 어느 하나 이상의 염기서열로 표시되는 유전자가 코딩하는 단백질에 특이적인 항체 또는 압타머인 것을 특징으로 할 수 있다.
본 발명에 있어서, 용어, "단백질 발현수준 측정"이란 암의 예후를 예측하기 위하여 생물학적 시료에서의 마커 유전자에서 발현된 단백질의 존재 여부와 발현 정도를 확인하는 과정으로, 상기 유전자에서 발현된 단백질에 대하여 특이적으로 결합하는 항체를 이용하여 단백질의 양을 확인할 수 있다. 이를 위한 분석 방법으로는 웨스턴블랏(western blotting), ELISA(enzyme linked immunosorbent assay), 방사선면역분석법(Radioimmunoassay), 방사면역확산법(Radioimmunodiffusion), 오우크레로니 (Ouchterlony) 면역 확산법, 로케트(Rocket) 면역전기영동, 조직면역 염색, 면역침전분석법(immunoprecipitation assay), 보체 고정 분석법(complete fixation assay), FACS, 단백질 칩(protein chip) 등이 있으나, 이에 제한되는 것은 아니다.
본 발명에서 용어, "항체"란 당해 분야에서 공지된 용어로서 항원성 부위에 대해서 지시되는 특이적인 단백질 분자를 의미한다. 본 발명의 목적상, 항체는 본 발명의 마커에 대해 특이적으로 결합하는 항체를 의미하며, 이러한 항체는 각 유전자를 통상적인 방법에 따라 발현벡터에 클로닝하여 상기 마커 유전자에 의해 코딩되는 단백질을 얻고, 얻어진 단백질로부터 통상적인 방법에 의해 제조될 수 있다. 여기에는 상기 단백질에서 만들어질 수 있는 부분 펩티드도 포함한다.
본 발명의 "항체"는 다클론 항체, 단클론 항체 및 재조합 항체 등을 모두 포함하며 항체란 항원성 부위에 대해서 지시되는 특이적인 단백질 분자를 의미한다.
다클론 항체는 항원을 동물에 주사하고 동물로부터 채혈하여 항체를 포함하는 혈청을 수득하는 당업계에 널리 공지된 방법에 의해 생산할 수 있다. 이러한 다클론 항체는 염소, 토끼, 양, 원숭이, 말, 돼지, 쥐, 랫트(rat), 소, 개 등의 임의의 동물 종 숙주로부터 제조 가능하다. 단클론 항체는 당업계에 널리 공지된 하이브리도마 방법(hybridoma method)(Kohler 및 Milstein (1976) European Jounral of Immunology 6:511-519 참조), 또는 파지 항체 라이브러리(Clackson et al, Nature, 352:624-628, 1991; Marks et al, J. Mol. Biol., 222:58, 1-597, 1991) 기술을 이용하여 제조될 수 있다. 상기 방법으로 제조된 항체는 겔 전기영동, 투석, 염 침전, 이온교환 크로마토그래피, 친화성 크로마토그래피 등의 방법을 이용하여 분리, 정제할 수 있다. 또한, 본 발명의 항체는 2개의 전체 길이의 경쇄 및 2개의 전체 길이의 중쇄를 가지는 완전한 형태뿐만 아니라, 항체 분자의 기능적인 단편을 포함한다. 항체 분자의 기능적인 단편이란 적어도 항원 결합 기능을 보유하고 있는 단편을 뜻하며, Fab, F(ab'), F(ab') 2 및 Fv 등이 있다.
즉, 본 발명에서는 서열번호 1 내지 105로 구성된 군에서 선택되는 어느 하나 이상의 염기서열로 표시되는 유전자가 코딩하는 단백질의 에피토프와 특이적으로 결합하는 모노클로날 항체 또는 폴리클로날 항체를 포함할 수 있다.
이러한 항체에는 일반적으로 알칼라인 포스파타제(alkaline phosphatase, AP) 또는 홀스래디쉬 퍼록시다제(horseradish peroxidase, HRP) 등의 효소가 컨쥬게이션된 2차 항체 및 이들의 기질을 사용하여 발색반응시킴으로써 정량분석하거나, 직접 상기 단백질 모노클로날 항체에 AP 또는 HRP 효소 등이 컨쥬게이션된 것을 사용하여 정량분석할 수도 있다.
본 발명은 다른 관점에서 서열번호 1 내지 105로 구성된 군에서 선택되는 어느 하나 이상의 염기서열로 표시되는 유전자의 mRNA 또는 상기 유전자가 코딩하는 단백질의 발현 수준을 측정할 수 있는 제제를 포함하는 교모세포종의 진단 또는 예후 예측용 조성물을 포함하는 교모세포종의 진단 또는 예후 예측용 키트에 관한 것이다.
본 발명의 키트는 분석 방법에 적합한 한 종류 또는 그 이상의 다른 구성 성분 조성물, 용액 또는 장치로 구성되고, RT-PCR 키트, DNA 칩 키트 또는 단백질 칩 키트일 수 있다. RT-PCR 키트는 마커 유전자에 대한 특이적인 각각의 프라이머 쌍 외에도 테스트 튜브 또는 다른 적절한 컨테이너, 반응 완충액, 데옥시뉴클레오타이드(dNTPs), Taq-폴리머라아제 및 역전사 효소와 같은 효소, DNase, RNase 억제제, DEPC-수, 멸균수 등을 포함할 수 있다. 또한, 정량 대조구로 사용되는 유전자에 특이적인 프라이머 쌍을 포함할 수 있다. DNA 칩 키트는 유전자 또는 그의 단편에 해당하는 cDNA가 프로브로 부착되어 있는 기판을 포함하고, 기판은 정량구조 유전자 또는 그의 단편에 해당하는 cDNA를 포함할 수 있다.
또한, 본 발명에 따른 키트는 상기 단백질 수준을 측정하는 제재를 포함하는 진단 키트일 수 있으며, 이때 상기 단백질 수준을 측정하는 제제는 바람직하게는 상기 단백질에 특이적인 항체이다. 따라서, 상기 단백질 수준을 측정하는 제제를 포함하는 진단 키트는, 예컨대, ELISA를 수행하기 위해 필요한 필수요소를 포함하는 진단 마커 검출용 키트일 수 있으며, 이러한 키트는 "항원-항체 복합체"를 형성한 항체를 검출할 수 있는 시약, 예컨대, 표지된 2차 항체, 발색단 (chromophores), 효소(예: 항체와 접합) 및 그의 기질 등을 포함할 수도 있다. 또한, 정량 대조구 단백질에 특이적인 항체를 포함할 수 있다.
아울러, 상기 항원-항체 복합체의 형성량은 검출 라벨(detection label)의 시그널의 크기를 통해서 정량적으로 측정할 수 있다. 이러한 검출 라벨은 효소, 형광물, 리간드, 발광물, 미소입자(microparticle), 레독스 분자 및 방사선 동위원소로 이루어진 그룹 중에서 선택할 수 있으며, 반드시 이로 제한되는 것은 아니다.
단백질 수준을 측정하기 위한 분석방법으로는 웨스턴 블롯, ELISA, 방사선면역분석, 방사선 면역 확산법, 오우크테로니 면역확산법, 로케트 면역전기영동, 조직면역 염색, 면역침전 분석법, 보체 고정분석법, FACS, 단백질 칩 등이 있으나, 이들로 제한되는 것은 아니며 당업자에게 공지된 방법을 사용하여 수행할 수 있다.
본 발명은 또 다른 관점에서 (a) 환자의 시료로부터 서열번호 1 내지 105로 구성된 군에서 선택되는 어느 하나 이상의 염기서열로 표시되는 유전자의 발현 수준 또는 상기 유전자가 코딩하는 단백질의 발현 수준을 측정하는 단계; 및 (b) 상기 측정된 유전자의 발현 수준 또는 상기 유전자가 코딩하는 단백질의 발현 수준을 대조군 시료와 비교하는 단계를 포함하는 교모세포종의 진단 또는 예후의 예측을 위한 정보제공 방법에 관한 것이다.
본 발명에 있어서, 상기 (b) 단계는 측정된 상기 서열번호 1 내지 105로 구성된 군에서 선택되는 어느 하나 이상의 염기서열로 표시되는 유전자의 발현 수준 또는 단백질의 발현 수준이 대조군에 비해 증가하는 경우, 교모세포종으로 확인 또는 재발로 확인하는 것을 특징으로 할 수 있다.
본 발명에 있어서, 상기 유전자는 MARCO, CD180, MMP8, CR1 또는 GPR18인 것이 바람직하나, 이에 한정되는 것은 아니다.
본 발명에서 용어, "환자의 시료"란 이에 제한되는 것은 아니나, 암 환자의 조직, 세포, 전혈, 혈청, 혈장일 수 있다.
본 발명에 있어서, 상기 시료는 조직 또는 세포로부터 분리된 종양 관련 대식세포인 것이 바람직하며, 상기 교모세포종은 중간엽 서브타입인 것이 바람직하나, 이에 한정되는 것은 아니다.
본 발명에서 용어, "메타유전자 스코어“는 중간엽 서브타입 관련 유전자 set를 RNA-Seq 데이터에 단일 샘플 유전자 세트 농축 스코어 (single sample gene set enrichment score, ssGSEA)라는 분석 방법을 사용하여 단일 스코어로 구한 값을 의미하며, 스코어가 높을수록 그 유전자 세트의 종합적인 발현정도가 높은 것을 의미한다.
교모세포종은 일단 진단되면 기대 생존기간이 1년에 불과하기 때문에 교모세포종의 예후를 예측하는 것은 매우 중요한데, 이에 따라 향후에 적용 가능한 치료방법 등이 달라지는 점에서 본 발명에서 교모세포종 진단 또는 예후 예측용 인자로 발굴한 MES-TAM signature는 예후가 좋은 환자군과 좋지 않은 환자군으로 구별할 수 있으므로 교모세포종 환자의 치료에 중요한 기준이 될 수 있다. 또한, 이를 이용하여 교모세포종의 치료법을 개발하는 데 유용하게 활용될 수 있다.
본 발명에서는 환자 유래 세포에서 분리한 종양 관련 대식세포 (TAM)를 직접 분리한 후 유전적 분석을 진행한 점에서 의미가 크고, 교모세포종 재발시 예후가 불량한 중간엽 교모세포종 (Mesenchymal GBM)으로 분화되는 것과 실제적으로 관련있는 특정 MES-TAM signature 614개 유전자를 개발하였다.
본 발명에서는 중간엽 교모세포종 (mesenchymal GBM; MES GBM) 및 비중간엽 교모세포종 (Non-mesechymal GBM; Non-MES GBM)을 기준으로 i) 비중간엽 교모세포종에서 비중간엽 교모세포종으로 재발한 환자그룹 (Non-MES to Non-MES); ii) 비중간엽 교모세포종에서 중간엽 교모세포종으로 재발한 환자그룹 (Non-MES to MES); iii) 중간엽 교모세포종에서 비중간엽 교모세포종으로 재발한 환자그룹 (MES to Non-MES); iv) 중간엽 교모세포종에서 중간엽 교모세포종으로 재발한 환자그룹의 4가지 그룹으로 나누어 예후와 종양 관련 대식세포 (TAM)의 침습을 분석함으로써, 예후가 불량한 중간엽 교모세포종 분화 그룹에서 TAM의 침습이 증가한 것을 확인할 수 있었다.
따라서, 중간엽 교모세포종 유래 TAM과 비중간엽 교모세포종 유래 TAM의 유전자 발현을 비교하여 중간엽 교모세포종 유래 TAM (MES-TAM)에서 높게 발현하는 MARCO를 포함한 614개 유전자를 발굴하였다.
이러한, 614개 유전자의 MES-TAM signature를 TCGA 교모세포종 (GBM) public data 데이터 및 55명 전발암-재발암 환자에 적용하여 환자 예후를 분석하여 검증하고, 특히 표 1의 105개 유전자의 MES-TAM signature score가 높을수록 환자의 예후가 좋지 않은, 예후 불량과 상관관계가 있음을 확인하였다. 105개 유전자의 MES-TAM signature는 TCGA microarray dataset (HU133A) 및 GSE16011 microarray dataset (HU133)에서 검증하였고, 항암화학요법 및 방사선 치료 환자군에서도 검증하였다. 아울러, 재발과정에서 105개 MES-TAM signature 유전자의 발현량이 증가하는 그룹과 변화없는 그룹으로 나누어 생존율을 검증한 결과, MES-TAM signature 유전자의 발현량이 증가하는 그룹이 유의하게 생존율이 감소하는 것을 확인할 수 있었다. 이는 TAM 이질성 (heterogeneity)을 고려한 새로운 암 면역치료로서의 전략을 제공할 수 있다.
[실시예]
이하, 실시예를 통하여 본 발명을 더욱 상세히 설명하고자 한다. 이들 실시예는 오로지 본 발명을 예시하기 위한 것으로서, 본 발명의 범위가 이들 실시예에 의해 제한되는 것으로 해석되지 않는 것은 당업계에서 통상의 지식을 가진 자에게 있어서 자명할 것이다.
실시예
1: 교모세포종 환자의
원발암
-
재발암
모델을 이용한
중간엽
교모세포종 (
Mesenchymal
GBM)으로의 재발 시 예후 분석
TCGA (The Cancer Genome Atlas), MD 앤더슨 암센터 (MDACC) 데이터 및 삼성서울병원과 서울대학교 병원에서 뇌종양 수술을 받은 교모세포종 (GBM) 환자들에게서 종양조직과 임상정보를 얻었다. 모든 환자로부터 정보제공 동의를 얻었으며, 이들의 임상자료는 삼성서울병원과 서울대학교 병원의 임상시험심사위원회 (Institutional Review Board)의 승인 하에 수집되고 분석하였다. 수술 전 영상검사를 바탕으로 초기 종양에 대한 재발암의 위치를 모든 재발암에 대해 결정하였다. 이렇게 수집된 전체 48명 교모세포종 (GBM) 환자의 원발암-재발암 모델을 이용하여 중간엽 교모세포종 (Mesenchymal GBM)으로 재발하는 환자의 예후를 확인하였다 (도 1).
자세하게는, 상기 48명 모델에서 중간엽 교모세포종 (mesenchymal GBM; MES GBM) 및 비중간엽 교모세포종 (Non-mesechymal GBM; Non-MES GBM)을 기준으로 4가지 환자그룹으로 나누어 분석을 진행하였다. i) 초기 비중간엽 교모세포종 (Non-MES GBM)에서 비중간엽 교모세포종 (Non-MES GBM)으로 재발한 환자그룹 (Non-MES to Non-MES); ii) 초기 비중간엽 교모세포종 (Non-MES GBM)에서 중간엽 교모세포종 (MES GBM)으로 재발한 환자그룹 (Non-MES to MES); iii) 초기 중간엽 교모세포종 (MES GBM)에서 비중간엽 교모세포종 (Non-MES GBM)으로 재발한 환자그룹 (MES to Non-MES); iv) 마지막으로 초기 중간엽 교모세포종 (MES GBM)에서 중간엽 교모세포종 (MES GBM)으로 재발한 환자그룹과 같이 4가지 그룹으로 나누어 분석하였다.
상기 4가지 그룹으로 나누어 환자의 예후를 카플란 마이어 생존 (Kaplan-Meier survival) 분석법을 이용해 살펴본 결과, 중간엽 교모세포종에서 중간엽 교모세포종 (MES to MES)으로 재발한 그룹과 비중간엽 교모세포종에서 중간엽 교모세포종 (Non-MES to MES)으로 재발한 그룹과 같이 중간엽 교모세포종 (mesenchymal GBM)으로 재발된 환자의 예후가 가장 불량하였다 (도 1).
실시예 2: 교모세포종 환자로부터 종양 관련 대식세포 분리 및 RNA sequencing 분석
9 케이스의 환자 유래 교모세포종 (GBM) 조직에서 종양 관련 대식세포 (TAM)를 분리하여 RNA sequencing을 진행하였다 (도 2).
동의서를 받은 교모세포종 (GBM) 환자에서 종양적출 수술 직후 얻은 GBM 조직을 CDD1 (Collagenase, Dispase, DNase Ⅰ)을 이용하여 단일 세포로 분할하였다. 그 단일세포를 CD45와 CD11b 항체를 이용해 염색하여 TAM과 TAM을 제외한 나머지 세포 (TAM-depleted population)의 2가지 세포 군집으로 분리하였다. 상기 TAM과 TAM을 제외한 나머지 세포로의 분리는 FACS Aria Ⅲ (BD Biosystems)를 이용하였으며, 이렇게 분리된 각 세포군집에서 RNA를 추출하여 RNA sequencing을 진행하였다. 또한, 분리된 TAM은 중간엽 교모세포종 (Mesenchymal GBM) 유래 TAM과 비중간엽 교모세포종 (Non-Mesenchymal 유래 TAM)으로 다시 한번 나누어 분리하였다 (도 2).
실시예 3: 종양 관련 대식세포 (TAM)에 특이적인 MES-TAM signature의 발굴
9 케이스의 환자 유래 교모세포종 (GBM)조직에서 종양 관련 대식세포 (TAM)를 분리하여 유전적 분석을 진행하였고, 분리된 TAM은 중간엽 교모세포종 (Mesenchymal GBM)과 관련된 TAM signature를 발굴하기 위해 TAM을 제외한 나머지 세포 (TAM-depleted population)군에서 종양 고유 중간엽 서브타입 유전자 세트에 대한 메타유전자 스코어를 구하였다 (도 2).
그 결과, 중간엽 서브타입 메타유전자 스코어와 양의 상관관계를 나타내는 종양 관련 대식세포 (TAM)에서 높게 발현하는 614개 유전자의 MES-TAM (Mesenchymal glioblastoma associated tumor associated macrophages) signature를 선별하였다 (표 2).
MES-TAM signature | |||||||
SOCS3 | SPG21 | IL1R2 | ARHGAP18 | LOC100506229 | PSMA3 | LDHA | CXCL2 |
CHI3L1 | SRD5A1 | LBX2-AS1 | CD163 | MR1 | PSMD7 | LITAF | DHRS3 |
MARCO | THBD | MET | CDA | MS4A6A | PTGES | MDFIC | DHX32 |
ALAS1 | TPST2 | NPL | CTSL1 | NEK6 | RAP2B | MTFP1 | DYNLT1 |
BST1 | AREG | PLA2G5 | CXCL1 | NOP10 | RBBP8 | NMRK1 | F11R |
CD180 | C14orf23 | POSTN | CXCL5 | NQO1 | RNF115 | NSUN2 | FCRLB |
MMP8 | CCL7 | RPL39L | CYB5B | PLEKHO2 | SLC31A1 | OXSM | FUCA2 |
PYGL | CD44 | S100A10 | DARS2 | PPIC | TDP1 | PIM1 | GALK2 |
ANXA2P2 | COL8A1 | SGMS2 | FBLN5 | PSMD6-AS2 | TEC | PSME1 | GYG1 |
CSTA | CPNE8 | SLC16A10 | FBP1 | RAB32 | TLR8 | PSTPIP2 | HEXB |
CXCL14 | DAB2 | SLC39A8 | FCGR2B | SAA1 | TMEM60 | RALB | HGF |
ERRFI1 | DRAM1 | SNX24 | HEXA | SLC38A6 | VLDLR | RFTN1 | KCNE1 |
LYZ | DSCR3 | TNFSF15 | IQGAP2 | SLC39A11 | WIPI1 | S100A6 | KIAA0391 |
PTX3 | FLVCR2 | ADA | LIMS1 | SQRDL | TFPI2 | S100A9 | LGALS3 |
SERPINB8 | FPR2 | ANKRD29 | LOC283050 | SYS1 | SPINK1 | SEC22B | LILRA6 |
SLC43A3 | GCNT1 | ANPEP | LONRF3 | TACSTD2 | A2LD1 | SEC23IP | LYVE1 |
VTI1B | GNS | ANXA2P1 | MCMBP | TGM2 | ACTL6A | SIGLEC9 | MAPKAPK3 |
ADAP2 | GSTK1 | ATL3 | MDH1 | UGP2 | ADAMTSL4 | SLC25A24 | P4HA1 |
APOBEC3B | HCAR3 | ATP6V1H | MED6 | UPP1 | AIM1 | SLC25A5 | PI4K2A |
CD38 | HTRA4 | B3GNT2 | MS4A4A | WDR61 | ANXA3 | SLC2A9 | PLEK2 |
CNDP2 | LACTB | C19orf59 | NECAP2 | ZCCHC4 | BLVRA | SLFN11 | PLIN2 |
COLEC12 | LILRA5 | CASP4 | NTAN1 | NPY | C10orf118 | SOAT1 | PNPLA4 |
CR1 | MAPK13 | CEACAM4 | PLSCR1 | PPBP | C5orf43 | SRD5A3 | RAB34 |
EDEM2 | MMP7 | DPEP2 | SDC4 | AIFM1 | CD36 | STARD3NL | S100A4 |
FUCA1 | PARVB | FOXP1 | SERPINB1 | ARPC2 | CD84 | SUCNR1 | SAP30 |
GALM | RPL23AP82 | GAL3ST4 | SLAMF8 | ATG10 | CLCF1 | SYNPO | SDCCAG8 |
GDPD2 | RRAGD | HCCS | SSR3 | ATG7 | CLIC1 | TFRC | SEC23B |
GPR18 | SNTB1 | HNMT | TGIF1 | C11orf45 | COX7C | THBS1 | SFT2D2 |
KYNU | SPOCD1 | IDH1 | TPD52L1 | C12orf49 | CPQ | TMSB10 | SLC16A6 |
LOX | TMEM37 | IL10 | UBXN8 | CD52 | CST6 | TPP1 | SNX2 |
LTA4H | ANXA2 | KDELR3 | VSIG10L | CNN2 | DAP3 | TREM1 | SRP54 |
OPN3 | AP1S2 | NCEH1 | ACRBP | CPNE4 | DNAJC5B | UQCRH | TCN2 |
PLP2 | AQP9 | PAX8 | ALDH3B1 | FGD6 | DPP4 | UTRN | TFG |
PPARG | ARL11 | PLEKHB2 | AMIGO2 | FLJ35776 | FAM65B | ZNF124 | TGFBI |
RAB13 | C14orf119 | PMP22 | APLP2 | GK3P | GALNT6 | ARPC5 | TM2D2 |
S100A8 | CASP6 | PPCS | APOBEC3C | HLA-DPB2 | GBE1 | AKR1A1 | TMEM2 |
SUMO3 | CATSPER1 | RBP4 | ATG3 | IRG1 | GCA | ALKBH1 | TMEM26 |
ANTXR2 | CCL18 | RNASEH2B | C2 | KMO | GGCT | ANKH | TNFSF8 |
CYP1B1 | CD68 | RPF2 | CA12 | LAIR1 | GLUL | ANXA1 | VAMP8 |
EYA4 | CD72 | SDC2 | CES1 | MYD88 | GMEB1 | ATP6V0D1 | VDAC3 |
FPR3 | COMMD9 | SERPINA3 | CLEC1A | NIP7 | GPRC5A | ATP6V0E1 | VMP1 |
HTATIP2 | CORO2A | SLC37A2 | DDX18 | NRP1 | HOXB6 | C14orf159 | ZNF552 |
LILRB3 | CXCL3 | SLC46A2 | ENOSF1 | NUCB2 | HP | C1GALT1C1 | ANKRD34B |
LOC100128993 | DUSP3 | TCTEX1D1 | F13A1 | OTOA | IFI35 | CAPZA1 | ACAA2 |
LOC653653 | FAH | TPM3P9 | GPNMB | PAPSS2 | IL10RB | CASP7 | ADM |
MOXD1 | FNDC3B | VDR | HADHB | PARN | IL1R1 | CD300C | AGXT2L2 |
NCF2 | FXYD5 | VSIG4 | HEXA-AS1 | PECAM1 | IL7R | CLEC12A | ALDH1A1 |
PHACTR2 | GNPDA1 | ALOX5AP | HRH1 | PGK1 | IQGAP1 | CLMN | ANAPC13 |
PLBD1 | IFNGR2 | ANXA2P3 | ITSN1 | POP4 | KATNA1 | COX7B | ASS1 |
ATP6V1A | PCTP | CCL2 | MT1H | ACP5 | GOLGA4 | SLC2A3 | CHPT1 |
C11orf63 | PKD2L1 | CCL8 | NUPR1 | ADSL | HK3 | STC1 | COL4A3BP |
CCDC18 | PLTP | CPM | PARP12 | ADTRP | HSD17B4 | SUMF2 | CXorf69 |
CCDC69 | PSMC2 | CSRP1 | PDCL3 | ALG14 | KCNJ15 | TAGLN2 | CYP27A1 |
CD59 | PSMD12 | CTSB | PIGL | ANGPTL4 | KLHDC8B | TNFSF13 | DAPK1 |
CRTAM | QPCT | DENND2D | PKIB | ANP32B | LACC1 | WDR1 | DNAJC15 |
CTSC | RARRES1 | DKK1 | PNKD | ARSJ | LAP3 | YIPF1 | FLVCR1-AS1 |
DCTD | RHOBTB1 | EDARADD | PSMC1 | ATP5G3 | LOC100506585 | ZNF438 | GARS |
FAM20A | RNF145 | EIF2S1 | RNF135 | ATP6V1C1 | LOC338758 | ZNF600 | GDE1 |
GLB1L | SDHB | EIF4E2 | RNF185 | BLOC1S1 | MB21D1 | LINC00460 | GHITM |
GLOD4 | TRPV4 | EMP1 | SEMA3C | C20orf24 | MICA | PSMA2 | HAUS2 |
GPR137B | TUBA1C | GEMIN6 | SERPINA1 | CAV2 | MRC1 | ABHD5 | HCAR2 |
HAT1 | TUBA4A | GJB2 | SH2D4A | CCL23 | MXD1 | AFG3L2 | HIBADH |
HFE | TXNRD1 | GLB1 | SLA | CELSR1 | NLN | ANXA7 | HRH2 |
HPS5 | VAMP5 | GRB2 | SLC25A43 | CFI | NRP2 | AP3B1 | IFI30 |
IBSP | VIM | GSTO1 | SNX6 | COL23A1 | P2RY1 | ARMC10 | IL1RN |
LOC283143 | TMSB4Y | HADHA | SRRD | CORO1C | PPM1M | ATF5 | IL7 |
LRRFIP1 | ABCC3 | HPRT1 | TMBIM1 | CPPED1 | PTMA | ATG4A | LGALS8 |
MAN1A1 | ACOT9 | IFNAR1 | TMOD3 | CTSS | RPGR | AZI2 | LOC100288432 |
MREG | ADORA2B | IL13RA2 | TTF2 | CYTIP | SDS | C12orf32 | LSP1 |
NCOA4 | ALOX15B | KDSR | ZBTB8OS | DLD | SEH1L | C6orf211 | LXN |
NT5DC1 | ATP6V1B2 | LRG1 | ZDHHC6 | DTNBP1 | SIAE | CD109 | MBD2 |
P4HA2 | C1orf88 | MICAL2 | SNORD12C | ERP29 | SIGLEC1 | CD63 | MED8 |
PCOLCE2 | CADM1 | MMP19 | MIR3945 | GMFG | SIGLEC7 | CEACAM21 | MFSD1 |
NIT2 | CARD6 | RRN3P1 | ABRACL | SNUPN | SLC22A4 | ZNF350 | MRPS15 |
NNMT | PFDN1 | S100A12 | SETDB2 | SNX3 | TCTA | SIGLEC14 | LINC00278 |
NR1H3 | PSMA5 | SEPHS2 | SLAMF9 | SPR | TXN | MS4A6E | |
NSRP1 | PSMG1 | SERPINF1 | SMS | SULT4A1 | ZMAT2 | SCARNA3 |
실시예 4: MES-TAM signature 유전자의 TCGA 교모세포종 데이터에 적용한 환자 예후 분석
실시예 3에서 발굴한 614개 유전자의 MES-TAM signature를 TCGA 교모세포종 (GBM) 데이터에 적용하여 환자의 예후를 살펴보았다 (도 3).
MES-TAM signature의 614개의 유전자를 이용하여 TCGA 전발암 GBM 공용 데이터에 적용하여 환자의 예후를 카플란 마이어 생존 (Kaplan-Meier survival) 분석법을 통하여 확인한 결과, MES-TAM signature가 높게 발현되어 있는 환자군이 낮게 발현되어 있는 환자에 비해 예후가 불량한 것을 확인하였다. 또한, 환자의 전발암이 중간엽 교모세포종이거나 비중간엽 교모세포종인 것과는 독립적으로 MES-TAM signature가 높게 발현되어 있는 환자일수록 예후가 불량한 것을 확인할 수 있었다 (도 3).
아울러, MES-TAM signature를 55명 교모세포종 (GBM) 환자에 적용 후 분석한 경우에도 중간엽 교모세포종으로 재발 시 상기 MES-TAM signature score가 높은 것을 확인할 수 있었고, MES-TAM signature는 중간엽 교모세포종 관련 유전자와 유의적인 양적 상관관계를 가지는 것을 확인하였다.
따라서, MES-TAM signature인 614개 유전자는 환자의 예후를 미리 예측 가능한 바이오마커임을 알 수 있다.
실시예 5: 105개 유전자 MES-TAM 특이 signature의 예후에 대한 유의성 검증
실시예 3에서 발굴한 614개 유전자에서 종양 관련 대식세포 (TAM) 특이적으로 발현되는 유전자 set을 선별하기 위해, 12 케이스의 GBM 환자 유래 orthotopic 이종이식편 RNA sequencing 결과에서 human signal (종양 세포에서 발현되는 유전자 발현)로 detection 되는 유전자 set을 제외하였다 (도 2). 이러한 과정을 거쳐 최종 105개 유전자 MES-TAM 특이 signature를 발굴하였다 (표 1).
이 signature의 예후의 중요성을 검증하기 위해, 외부 GBM dataset인 TCGA (microarray dataset & RNA-Seq dataset)와 GSE16011, 그리고 삼성서울병원의 48 primary and paired recurrent GBM samples (longitudinal pair)을 활용하였다.
5-1:
TCGA
microarray
dataset
(
HU133A
) 및
GSE16011
microarray
dataset
(HU133)에서 검증
실시예 3에서 발굴한 105개 유전자의 MES-TAM 특이 signature의 메타유전자 스코어를 비교하였다 (도 4). TCGA microarray dataset (HU133A)에서는 정상조직에 비해 IDH1 돌연변이가 없는 일차 교모세포종 (IDH1 WT) 환자 352명에서 MES-TAM 특이 signature의 메타유전자 스코어가 높게 나타났으며, 다른 dataset인 GSE16011 microarray dataset (HU133)에서도 정상이나 grade 1-II, grade III에 비해 grade IV에 해당되는 GBM이 MES-TAM 특이 signature의 메타유전자 스코어가 높게 나타났다.
5-2:
TCGA
microarray
dataset
(
HU133A
) 및
TCGA
RNA sequencing
dataset에서
검증
MES-TAM signature의 105개의 유전자를 이용하여 IDH1 돌연변이가 없는 일차 교모세포종 TCGA microarray dataset (U133A) 환자 352명에 적용하여 환자의 예후를 카플란 마이어 생존 (Kaplan-Meier survival) 분석법을 통하여 확인한 결과, MES-TAM signature가 높게 발현되어 있는 환자군 (상위 2/3)의 중앙 전체생존기간 (median overall survival, OS)은 MES-TAM signature가 낮게 발현되어 있는 환자군 (하위1/3)에 비해 예후가 불량한 것을 확인하였다 (도 5).
또한, 이들 환자군중 기본 치료인 항암화학요법 (chemoradiation)을 받은 환자 142명만을 대상으로 국한하여 재분석하였을 때에도 역시 예후 significance는 유지되었고, TCGA RNA Sequencing dataset에서도 이러한 경향성은 유지되었다 (도 5).
5-3: 방사선 치료를 받은 일차 교모세포종
GSE16011
(
HU133A
)
dataset에서의
검증
교모세포종으로의 TAM 축적 (recruitment and accumulation)이 방사선 치료에 의한 저산소증 (hypoxia)과 관련이 높으므로, 105개의 유전자의 MES-TAM signature의 예후를 GSE16011(HU133A) dataset에서 방사선 치료를 받은 그룹과 방사선 치료를 받지 않은 그룹에서 분석하였다.
그 결과, 방사선 치료를 받은 그룹에서만 MES-TAM 특이 signature의 메타유전자 스코어가 예후와 관련있는 것으로 분석되었다 (도 6). 이는 주로 방사선에 의해 TAM이 종양으로 recruitment 된다는 사실에 부합하는 결과이다.
실시예
6:
IDH1
돌연변이가 없는 일차 교모세포종 종단 (longitudinal) 샘플의 RNA sequencing 결과
48쌍의 IDH1 WT 종단 (longitudinal) 샘플의 RNA-Seq data에서 각 case 마다 진행하는 동안의 유전자 발현의 변화량(Δ)을 구하였다. 각 case 마다의 변화량을 105개 유전자 MES TAM-특이 signature로 계층적 클러스터링 (achial clustering)을 하였을 때 크게 재발 과정에서 MES-TAM signature 유전자 set의 발현량이 증가한 클러스트 1과 재발 과정에서 MES-TAM signature 유전자 set의 발현량이 크게 변화 없거나 감소한 클러스트 2로 구분되었다.
분석 결과, 특히 클러스트 1에 중간엽으로 재발하는 그룹인 M to M (중간엽 교모세포종에서 중간엽 교모세포종 (MES to MES)으로 재발한 그룹) 및 NM to M (비중간엽 교모세포종에서 중간엽 교모세포종 (Non-MES to MES)으로 재발한 그룹)이 클러스트 2에 비해 유의하게 많이 포함되어 있었다 (도 7). 또한 클러스트 1이 클러스트 2에 비해 유의하게 생존률이 감소함을 확인하였다.
아울러, GSEA 분석을 통해 105개 유전자 MES TAM-특이 signature가 NM to M 그룹에서는 재발 샘플에, M to NM 그룹에서는 반대로 Primary sample에 enrich 되어 있음을 확인하였다 (도 8).
이상으로 본 발명 내용의 특정한 부분을 상세히 기술하였는바, 당업계의 통상의 지식을 가진 자에게 있어서 이러한 구체적 기술은 단지 바람직한 실시태양일 뿐이며, 이에 의해 본 발명의 범위가 제한되는 것이 아닌 점은 명백할 것이다. 따라서, 본 발명의 실질적인 범위는 첨부된 청구항들과 그것들의 등가물에 의하여 정의된다고 할 것이다.
<110> Samsung Life Public Welfare Foundation
<120> Biomarker for Diagnosis or Prognosis of Glioblastoma and the Use
Thereof
<130> P16-B339
<160> 105
<170> KoPatentIn 3.0
<210> 1
<211> 1853
<212> DNA
<213> Homo sapiens
<400> 1
gccaaaggga agtgctgcga ggtttacaac cagctgcagt ggttcgatgg gaaggatctt 60
tctccaagtg gttcctcttg aggggagcat ttctgctggc tccaggactt tggccatcta 120
taaagcttgg caatgagaaa taagaaaatt ctcaaggagg acgagctctt gagtgagacc 180
caacaagctg cttttcacca aattgcaatg gagcctttcg aaatcaatgt tccaaagccc 240
aagaggagaa atggggtgaa cttctcccta gctgtggtgg tcatctacct gatcctgctc 300
accgctggcg ctgggctgct ggtggtccaa gttctgaatc tgcaggcgcg gctccgggtc 360
ctggagatgt atttcctcaa tgacactctg gcggctgagg acagcccgtc cttctccttg 420
ctgcagtcag cacaccctgg agaacacctg gctcagggtg catcgaggct gcaagtcctg 480
caggcccaac tcacctgggt ccgcgtcagc catgagcact tgctgcagcg ggtagacaac 540
ttcactcaga acccagggat gttcagaatc aaaggtgaac aaggcgcccc aggtcttcaa 600
ggtcacaagg gggccatggg catgcctggt gcccctggcc cgccgggacc acctgctgag 660
aagggagcca agggggctat gggacgagat ggagcaacag gcccctcggg accccaaggc 720
ccaccgggag tcaagggaga ggcgggcctc caaggacccc agggtgctcc agggaagcaa 780
ggagccactg gcaccccagg accccaagga gagaagggca gcaaaggcga tgggggtctc 840
attggcccaa aaggggaaac tggaactaag ggagagaaag gagacctggg tctcccagga 900
agcaaagggg acaggggcat gaaaggagat gcaggggtca tggggcctcc tggagcccag 960
gggagtaaag gtgacttcgg gaggccaggc ccaccaggtt tggctggttt tcctggagct 1020
aaaggagatc aaggacaacc tggactgcag ggtgttccgg gccctcctgg tgcagtggga 1080
cacccaggtg ccaagggtga gcctggcagt gctggctccc ctgggcgagc aggacttcca 1140
gggagccccg ggagtccagg agccacaggc ctgaaaggaa gcaaagggga cacaggactt 1200
caaggacagc aaggaagaaa aggagaatca ggagttccag gccctgcagg tgtgaaggga 1260
gaacagggga gcccagggct ggcaggtccc aagggagccc ctggacaagc tggccagaag 1320
ggagaccagg gagtgaaagg atcttctggg gagcaaggag taaagggaga aaaaggtgaa 1380
agaggtgaaa actcagtgtc cgtcaggatt gtcggcagta gtaaccgagg ccgggctgaa 1440
gtttactaca gtggtacctg ggggacaatt tgcgatgacg agtggcaaaa ttctgatgcc 1500
attgtcttct gccgcatgct gggttactcc aaaggaaggg ccctgtacaa agtgggagct 1560
ggcactgggc agatctggct ggataatgtt cagtgtcggg gcacggagag taccctgtgg 1620
agctgcacca agaatagctg gggccatcat gactgcagcc acgaggagga cgcaggcgtg 1680
gagtgcagcg tctgacccgg aaaccctttc acttctctgc tcccgaggtg tcctcgggct 1740
catatgtggg aaggcagagg atctctgagg agttccctgg ggacaactga gcagcctctg 1800
gagaggggcc attaataaag ctcaacatca ttggcaaaaa aaaaaaaaaa aaa 1853
<210> 2
<211> 2725
<212> DNA
<213> Homo sapiens
<400> 2
agaatgctga gcagtcaaca gcatttcttg ttccaagatc acccttctga gtacctctct 60
ggctgccaaa ttgccagggc cttcacagtt tgattccatt tctcagctcc aagcattagg 120
taaacccacc aagcaatcct agcctgtgat ggcgtttgac gtcagctgct tcttttgggt 180
ggtgctgttt tctgccggct gtaaagtcat cacctcctgg gatcagatgt gcattgagaa 240
agaagccaac aaaacatata actgtgaaaa tttaggtctc agtgaaatcc ctgacactct 300
accaaacaca acagaatttt tggaattcag ctttaatttt ttgcctacaa ttcacaatag 360
aaccttcagc agactcatga atcttacctt tttggattta actaggtgcc agattaactg 420
gatacatgaa gacacttttc aaagccatca tcaattaagc acacttgtgt taactggaaa 480
tcccctgata ttcatggcag aaacatcgct taatgggccc aagtcactga agcatctttt 540
cttaatccaa acgggaatat ccaatctcga gtttattcca gtgcacaatc tggaaaactt 600
ggaaagcttg tatcttggaa gcaaccatat ttcctccatt aagttcccca aagacttccc 660
agcacggaat ctgaaagtac tggattttca gaataatgct atacactaca tctctagaga 720
agacatgagg tctctggagc aggccatcaa cctaagcctg aacttcaatg gcaataatgt 780
taaaggtatt gagcttgggg cttttgattc aacgatcttc caaagtttga actttggagg 840
aactccaaat ttgtctgtta tattcaatgg tctgcagaac tctactactc agtctctctg 900
gctgggaaca tttgaggaca ttgatgacga agatattagt tcagccatgc tcaagggact 960
ctgtgaaatg tctgttgaga gcctcaacct gcaggaacac cgcttctctg acatctcatc 1020
caccacattt cagtgcttca cccaactcca agaattggat ctgacagcaa ctcacttgaa 1080
agggttaccc tctgggatga agggtctgaa cttgctcaag aaattagttc tcagtgtaaa 1140
tcatttcgat caattgtgtc aaatcagtgc tgccaatttc ccctccctta cacacctcta 1200
catcagaggc aacgtgaaga aacttcacct tggtgttggc tgcttggaga aactaggaaa 1260
ccttcagaca cttgatttaa gccataatga catagaggct tctgactgct gcagtctgca 1320
actcaaaaac ctgtcccact tgcaaacctt aaacctgagc cacaatgagc ctcttggtct 1380
ccagagtcag gcattcaaag aatgtcctca gctagaactc ctcgatttgg catttacccg 1440
cttacacatt aatgctccac aaagtccctt ccaaaacctc catttccttc aggttctgaa 1500
tctcacttac tgcttccttg ataccagcaa tcagcatctt ctagcaggcc taccagttct 1560
ccggcatctc aacttaaaag ggaatcactt tcaagatggg actatcacga agaccaacct 1620
acttcagacc gtgggcagct tggaggttct gattttgtcc tcttgtggtc tcctctctat 1680
agaccagcaa gcattccaca gcttgggaaa aatgagccat gtagacttaa gccacaacag 1740
cctgacatgc gacagcattg attctcttag ccatcttaag ggaatctacc tcaatctggc 1800
tgccaacagc attaacatca tctcaccccg tctcctccct atcttgtccc agcagagcac 1860
cattaattta agtcataacc ccctggactg cacttgctcg aatattcatt tcttaacatg 1920
gtacaaagaa aacctgcaca aacttgaagg ctcggaggag accacgtgtg caaacccgcc 1980
atctctaagg ggagttaagc tatctgatgt caagctttcc tgtgggatta cagccatagg 2040
cattttcttt ctcatagtat ttctattatt gttggctatt ctgctatttt ttgcagttaa 2100
ataccttctc aggtggaaat accaacacat ttagtgctga aggtttccag agaaagcaaa 2160
taagtgtgct tagcaaaatt gctctaagtg aaagaactgt catctgctgg tgaccagacc 2220
agacttttca gattgcttcc tggaactggg cagggactca ctgtgctttt ctgagcttct 2280
tactcctgtg agtcccagag ctaaagaacc ttctaggcaa gtacaccgaa tgactcagtc 2340
cagagggtca gatgctgctg tgagaggcac agagcccttt ccgcatgtgg aagagtggga 2400
ggaagcagag ggagggactg ggcagggact gccggccccg gagtctccca cagggaggcc 2460
attccccttc tactcaccga catccctccc agcaccacac accccgcccc tgaaaggaga 2520
tcatcagccc ccacaatttg tcagagctga agccagccca ctacccaccc ccactacagc 2580
attgtgcttg ggtctgggtt ctcagtaatg tagccatttg agaaacttac ttggggacaa 2640
agtctcaatc cttattttaa atgaaaaaag aaaagaaaag cataataaat ttaaaagaaa 2700
aggctgagaa atgaaaaaaa aaaaa 2725
<210> 3
<211> 3056
<212> DNA
<213> Homo sapiens
<400> 3
gacacatgat gctgtgaacg tcagggtgct cgccagggaa gggccctacc cagagggaca 60
gaaagaaagc caggaggggt agagtttgaa gagaagatca tgttctccct gaagacgctt 120
ccatttctgc tcttactcca tgtgcagatt tccaaggcct ttcctgtatc ttctaaagag 180
aaaaatacaa aaactgttca ggactacctg gaaaagttct accaattacc aagcaaccag 240
tatcagtcta caaggaagaa tggcactaat gtgatcgttg aaaagcttaa agaaatgcag 300
cgattttttg ggttgaatgt gacggggaag ccaaatgagg aaactctgga catgatgaaa 360
aagcctcgct gtggagtgcc tgacagtggt ggttttatgt taaccccagg aaaccccaag 420
tgggaacgca ctaacttgac ctacaggatt cgaaactata ccccacagct gtcagaggct 480
gaggtagaaa gagctatcaa ggatgccttt gaactctgga gtgttgcatc acctctcatc 540
ttcaccagga tctcacaggg agaggcagat atcaacattg ctttttacca aagagatcac 600
ggtgacaatt ctccatttga tggacccaat ggaatccttg ctcatgcctt tcagccaggc 660
caaggtattg gaggagatgc tcattttgat gccgaagaaa catggaccaa cacctccgca 720
aattacaact tgtttcttgt tgctgctcat gaatttggcc attctttggg gctcgctcac 780
tcctctgacc ctggtgcctt gatgtatccc aactatgctt tcagggaaac cagcaactac 840
tcactccctc aagatgacat cgatggcatt caggccatct atggactttc aagcaaccct 900
atccaaccta ctggaccaag cacacccaaa ccctgtgacc ccagtttgac atttgatgct 960
atcaccacac tccgtggaga aatacttttc tttaaagaca ggtacttctg gagaaggcat 1020
cctcagctac aaagagtcga aatgaatttt atttctctat tctggccatc ccttccaact 1080
ggtatacagg ctgcttatga agattttgac agagacctca ttttcctatt taaaggcaac 1140
caatactggg ctctgagtgg ctatgatatt ctgcaaggtt atcccaagga tatatcaaac 1200
tatggcttcc ccagcagcgt ccaagcaatt gacgcagctg ttttctacag aagtaaaaca 1260
tacttctttg taaatgacca attctggaga tatgataacc aaagacaatt catggagcca 1320
ggttatccca aaagcatatc aggtgccttt ccaggaatag agagtaaagt tgatgcagtt 1380
ttccagcaag aacatttctt ccatgtcttc agtggaccaa gatattacgc atttgatctt 1440
attgctcaga gagttaccag agttgcaaga ggcaataaat ggcttaactg tagatatggc 1500
tgaagcaaaa tcaaatgtgg ctgtatccac tttcagaatg ttgaagggaa gttcagcaag 1560
cattttcgtt acattgtgtc ctgcttatac ttttctcaat attaagtcat tgtttcccat 1620
cactgtatcc attctacctg tcctccgtga aaatatgttt ggaatattcc actatttgca 1680
gaggcttatt cagttcttac acattccatc ttacattagt gattccatca aagagaagga 1740
aagtaagcct ttttgtcacc tcaatattta ctatttcaat acttacatat ctgacttcta 1800
ggatttattg ttatattact tgcctatctg acttcataca tccctcagtt tcttaaaatg 1860
tcctatgtat atcttctaca tgcaatttag aactagattt tggttagaag taaggattat 1920
aaacaaccta gacagtaccc ttggccttta cagaaaatat ggtgctgttt tctacccttg 1980
gaaagaaatg tagatgatat gtttcgtggg ttgaattgtg tcccccataa aagatatgtt 2040
gaagttctaa ccccaggtac ccatgaatgt gagcttacca gggtctttgc agatgtaatt 2100
agttaagtta aggtgagatc acactgaatt agggtgggct ctaaatccat tatgactgtt 2160
gttcttataa gaagaagaga ggcatagtca cctaggggag gaggccgtat gaagacagag 2220
gcagagattg gagtgacgca tctccaagcc aaggaattcc aaggactgta agccaccagt 2280
agaagctttg aagaggcaag gaaggattcc ctccaatagc cttcaagtgt gaccctgctg 2340
acacctgcag aattcggact tctatcctcc aaaaccgtga gggaataaat ttcctttgtt 2400
ttaagccacc aactttgcaa tactttgtta cagcaaccct agacatgagg tactagacac 2460
agtacatcta cacatatgaa aatgaatcaa cacagaatgc agaagtagaa cccttgctaa 2520
ggactactgg gcatcttccc aggacagcag ccaaaagaga accaccactt cctctcctgc 2580
ctcctccttg ctctctccta gagtccaaac ccaaatgggc cagttggatc tgatgttcgt 2640
cagttcttta cttctatttc ctggggtact caggagggca cacactatag ataacttggg 2700
ttagctgcat aaaattcaat gtctcattaa gttgcattaa actgagctta gatgtgtaag 2760
tttgctaacg gatgggtttt tttgttaaga actataggat ttatgggacc aagtctagcg 2820
agtccagata tcaaaatcat tataatgtta tatttgctgt tattagaata taatatagct 2880
tattatacaa taaatatgta gactgtaaaa tatatttctc actagtacct cctattttct 2940
ttctctgttg aagtttttaa atcccacaga taattaaatt ggcaccttta tgcttgttca 3000
aaaattaaaa taatctatta aataagttca aattaaagat ttttacttca aatgac 3056
<210> 4
<211> 8629
<212> DNA
<213> Homo sapiens
<400> 4
ttttgtcccg gaaccccgca gccctcccca cactctgggc gcggagcaca atgattggtc 60
actcctattt tcgctgagct tttcctctta tttcagtttt cttcgagatc aaatctggtt 120
tgtagatgtg cttggggaga atgggggcct cttctccaag aagcccggag cctgtcgggc 180
cgccggcgcc cggtctcccc ttctgctgcg gaggatccct gctggcggtt gtggtgctgc 240
ttgcgctgcc ggtggcctgg ggtcaatgca atgccccaga atggcttcca tttgccaggc 300
ctaccaacct aactgatgaa tttgagtttc ccattgggac atatctgaac tatgaatgcc 360
gccctggtta ttccggaaga ccgttttcta tcatctgcct aaaaaactca gtctggactg 420
gtgctaagga caggtgcaga cgtaaatcat gtcgtaatcc tccagatcct gtgaatggca 480
tggtgcatgt gatcaaaggc atccagttcg gatcccaaat taaatattct tgtactaaag 540
gataccgact cattggttcc tcgtctgcca catgcatcat ctcaggtgat actgtcattt 600
gggataatga aacacctatt tgtgacagaa ttccttgtgg gctacccccc accatcacca 660
atggagattt cattagcacc aacagagaga attttcacta tggatcagtg gtgacctacc 720
gctgcaatcc tggaagcgga gggagaaagg tgtttgagct tgtgggtgag ccctccatat 780
actgcaccag caatgacgat caagtgggca tctggagcgg ccccgcccct cagtgcatta 840
tacctaacaa atgcacgcct ccaaatgtgg aaaatggaat attggtatct gacaacagaa 900
gcttattttc cttaaatgaa gttgtggagt ttaggtgtca gcctggcttt gtcatgaaag 960
gaccccgccg tgtgaagtgc caggccctga acaaatggga gccggagcta ccaagctgct 1020
ccagggtatg tcagccacct ccagatgtcc tgcatgctga gcgtacccaa agggacaagg 1080
acaacttttc acctgggcag gaagtgttct acagctgtga gcccggctac gacctcagag 1140
gggctgcgtc tatgcgctgc acaccccagg gagactggag ccctgcagcc cccacatgtg 1200
aagtgaaatc ctgtgatgac ttcatgggcc aacttcttaa tggccgtgtg ctatttccag 1260
taaatctcca gcttggagca aaagtggatt ttgtttgtga tgaaggattt caattaaaag 1320
gcagctctgc tagttactgt gtcttggctg gaatggaaag cctttggaat agcagtgttc 1380
cagtgtgtga acaaatcttt tgtccaagtc ctccagttat tcctaatggg agacacacag 1440
gaaaacctct ggaagtcttt ccctttggga aaacagtaaa ttacacatgc gacccccacc 1500
cagacagagg gacgagcttc gacctcattg gagagagcac catccgctgc acaagtgacc 1560
ctcaagggaa tggggtttgg agcagccctg cccctcgctg tggaattctg ggtcactgtc 1620
aagccccaga tcattttctg tttgccaagt tgaaaaccca aaccaatgca tctgactttc 1680
ccattgggac atctttaaag tacgaatgcc gtcctgagta ctacgggagg ccattctcta 1740
tcacatgtct agataacctg gtctggtcaa gtcccaaaga tgtctgtaaa cgtaaatcat 1800
gtaaaactcc tccagatcca gtgaatggca tggtgcatgt gatcacagac atccaggttg 1860
gatccagaat caactattct tgtactacag ggcaccgact cattggtcac tcatctgctg 1920
aatgtatcct ctcgggcaat gctgcccatt ggagcacgaa gccgccaatt tgtcaacgaa 1980
ttccttgtgg gctacccccc accatcgcca atggagattt cattagcacc aacagagaga 2040
attttcacta tggatcagtg gtgacctacc gctgcaatcc tggaagcgga gggagaaagg 2100
tgtttgagct tgtgggtgag ccctccatat actgcaccag caatgacgat caagtgggca 2160
tctggagcgg cccggcccct cagtgcatta tacctaacaa atgcacgcct ccaaatgtgg 2220
aaaatggaat attggtatct gacaacagaa gcttattttc cttaaatgaa gttgtggagt 2280
ttaggtgtca gcctggcttt gtcatgaaag gaccccgccg tgtgaagtgc caggccctga 2340
acaaatggga gccggagcta ccaagctgct ccagggtatg tcagccacct ccagatgtcc 2400
tgcatgctga gcgtacccaa agggacaagg acaacttttc acccgggcag gaagtgttct 2460
acagctgtga gcccggctat gacctcagag gggctgcgtc tatgcgctgc acaccccagg 2520
gagactggag ccctgcagcc cccacatgtg aagtgaaatc ctgtgatgac ttcatgggcc 2580
aacttcttaa tggccgtgtg ctatttccag taaatctcca gcttggagca aaagtggatt 2640
ttgtttgtga tgaaggattt caattaaaag gcagctctgc tagttattgt gtcttggctg 2700
gaatggaaag cctttggaat agcagtgttc cagtgtgtga acaaatcttt tgtccaagtc 2760
ctccagttat tcctaatggg agacacacag gaaaacctct ggaagtcttt ccctttggaa 2820
aagcagtaaa ttacacatgc gacccccacc cagacagagg gacgagcttc gacctcattg 2880
gagagagcac catccgctgc acaagtgacc ctcaagggaa tggggtttgg agcagccctg 2940
cccctcgctg tggaattctg ggtcactgtc aagccccaga tcattttctg tttgccaagt 3000
tgaaaaccca aaccaatgca tctgactttc ccattgggac atctttaaag tacgaatgcc 3060
gtcctgagta ctacgggagg ccattctcta tcacatgtct agataacctg gtctggtcaa 3120
gtcccaaaga tgtctgtaaa cgtaaatcat gtaaaactcc tccagatcca gtgaatggca 3180
tggtgcatgt gatcacagac atccaggttg gatccagaat caactattct tgtactacag 3240
ggcaccgact cattggtcac tcatctgctg aatgtatcct ctcaggcaat actgcccatt 3300
ggagcacgaa gccgccaatt tgtcaacgaa ttccttgtgg gctaccccca accatcgcca 3360
atggagattt cattagcacc aacagagaga attttcacta tggatcagtg gtgacctacc 3420
gctgcaatct tggaagcaga gggagaaagg tgtttgagct tgtgggtgag ccctccatat 3480
actgcaccag caatgacgat caagtgggca tctggagcgg ccccgcccct cagtgcatta 3540
tacctaacaa atgcacgcct ccaaatgtgg aaaatggaat attggtatct gacaacagaa 3600
gcttattttc cttaaatgaa gttgtggagt ttaggtgtca gcctggcttt gtcatgaaag 3660
gaccccgccg tgtgaagtgc caggccctga acaaatggga gccagagtta ccaagctgct 3720
ccagggtgtg tcagccgcct ccagaaatcc tgcatggtga gcatacccca agccatcagg 3780
acaacttttc acctgggcag gaagtgttct acagctgtga gcctggctat gacctcagag 3840
gggctgcgtc tctgcactgc acaccccagg gagactggag ccctgaagcc ccgagatgtg 3900
cagtgaaatc ctgtgatgac ttcttgggtc aactccctca tggccgtgtg ctatttccac 3960
ttaatctcca gcttggggca aaggtgtcct ttgtctgtga tgaagggttt cgcttaaagg 4020
gcagttccgt tagtcattgt gtcttggttg gaatgagaag cctttggaat aacagtgttc 4080
ctgtgtgtga acatatcttt tgtccaaatc ctccagctat ccttaatggg agacacacag 4140
gaactccctc tggagatatt ccctatggaa aagaaatatc ttacacatgt gacccccacc 4200
cagacagagg gatgaccttc aacctcattg gggagagcac catccgctgc acaagtgacc 4260
ctcatgggaa tggggtttgg agcagccctg cccctcgctg tgaactttct gttcgtgctg 4320
gtcactgtaa aaccccagag cagtttccat ttgccagtcc tacgatccca attaatgact 4380
ttgagtttcc agtcgggaca tctttgaatt atgaatgccg tcctgggtat tttgggaaaa 4440
tgttctctat ctcctgccta gaaaacttgg tctggtcaag tgttgaagac aactgtagac 4500
gaaaatcatg tggacctcca ccagaaccct tcaatggaat ggtgcatata aacacagata 4560
cacagtttgg atcaacagtt aattattctt gtaatgaagg gtttcgactc attggttccc 4620
catctactac ttgtctcgtc tcaggcaata atgtcacatg ggataagaag gcacctattt 4680
gtgagatcat atcttgtgag ccacctccaa ccatatccaa tggagacttc tacagcaaca 4740
atagaacatc ttttcacaat ggaacggtgg taacttacca gtgccacact ggaccagatg 4800
gagaacagct gtttgagctt gtgggagaac ggtcaatata ttgcaccagc aaagatgatc 4860
aagttggtgt ttggagcagc cctccccctc ggtgtatttc tactaataaa tgcacagctc 4920
cagaagttga aaatgcaatt agagtaccag gaaacaggag tttctttacc ctcactgaga 4980
tcatcagatt tagatgtcag cccgggtttg tcatggtagg gtcccacact gtgcagtgcc 5040
agaccaatgg cagatggggg cccaagctgc cacactgctc cagggtgtgt cagccgcctc 5100
cagaaatcct gcatggtgag cataccctaa gccatcagga caacttttca cctgggcagg 5160
aagtgttcta cagctgtgag cccagctatg acctcagagg ggctgcgtct ctgcactgca 5220
cgccccaggg agactggagc cctgaagccc ctagatgtac agtgaaatcc tgtgatgact 5280
tcctgggcca actccctcat ggccgtgtgc tacttccact taatctccag cttggggcaa 5340
aggtgtcctt tgtttgcgat gaagggttcc gattaaaagg caggtctgct agtcattgtg 5400
tcttggctgg aatgaaagcc ctttggaata gcagtgttcc agtgtgtgaa caaatctttt 5460
gtccaaatcc tccagctatc cttaatggga gacacacagg aactcccttt ggagatattc 5520
cctatggaaa agaaatatct tacgcatgcg acacccaccc agacagaggg atgaccttca 5580
acctcattgg ggagagctcc atccgctgca caagtgaccc tcaagggaat ggggtttgga 5640
gcagccctgc ccctcgctgt gaactttctg ttcctgctgc ctgcccacat ccacccaaga 5700
tccaaaacgg gcattacatt ggaggacacg tatctctata tcttcctggg atgacaatca 5760
gctacatttg tgaccccggc tacctgttag tgggaaaggg cttcattttc tgtacagacc 5820
agggaatctg gagccaattg gatcattatt gcaaagaagt aaattgtagc ttcccactgt 5880
ttatgaatgg aatctcgaag gagttagaaa tgaaaaaagt atatcactat ggagattatg 5940
tgactttgaa gtgtgaagat gggtatactc tggaaggcag tccctggagc cagtgccagg 6000
cggatgacag atgggaccct cctctggcca aatgtacctc tcgtacacat gatgctctca 6060
tagttggcac tttatctggt acgatcttct ttattttact catcattttc ctctcttgga 6120
taattctaaa gcacagaaaa ggcaataatg cacatgaaaa ccctaaagaa gtggctatcc 6180
atttacattc tcaaggaggc agcagcgttc atccccgaac tctgcaaaca aatgaagaaa 6240
atagcagggt ccttccttga caaagtacta tacagctgaa gaacatctcg aatacaattt 6300
tggtgggaaa ggagccaatt gatttcaaca gaatcagatc tgagcttcat aaagtctttg 6360
aagtgacttc acagagacgc agacatgtgc acttgaagat gctgcccctt ccctggtacc 6420
tagcaaagct cctgcctctt tgtgtgcgtc actgtgaaac ccccaccctt ctgcctcgtg 6480
ctaaacgcac acagtatcta gtcaggggaa aagactgcat ttaggagata gaaaatagtt 6540
tggattactt aaaggaataa ggtgttgcct ggaatttctg gtttgtaagg tggtcactgt 6600
tcttttttaa aatatttgta atatggaatg ggctcagtaa gaagagcttg gaaaatgcag 6660
aaagttatga aaaataagtc acttataatt atgctaccta ctgataacca ctcctaatat 6720
tttgattcat tttctgccta tcttctttca catatgtgtt tttttacata cgtacttttc 6780
ccccttagtt tgtttccttt tattttatag agcagaaccc tagtctttta aacagtttag 6840
agtgaaatat atgctatatc agtttttact ttctctaggg agaaaaatta atttactaga 6900
aaggcatgaa atgatcatgg gaagagtggt taagactact gaagagaaat atttggaaaa 6960
taagatttcg atatcttctt tttttttgag atggagtctg gctctgtctc ccaggctgga 7020
gtgcagtggc gtaatctcgg ctcactgcaa gctccgcctc ccgggttgac accattttcc 7080
tgcctcagcc tcctgagtag ttgggattac cagtagatgg gactacaggc acctgccaac 7140
acgcccggct aatttttttg tatttttagt agagacgggg tttcaccatg ttagccagga 7200
tggtctggat ctcctgacct cgtgatccac ctgcctcggc ctcccaaagt gctgcgatta 7260
caggcatgag ccaccgcgcc tggccgcttt cgatattttc taaactttaa ttcaaaagca 7320
ctttgtgctg tgttctatat aaaaaacata ataaaaattg aaatgaaaga ataattgtta 7380
ttataaaagt actagcttac ttttgtatgg attcagaata tactaaatta actttttaaa 7440
acacaacttt taaaaaatgt atcaaaataa taaacgtgtt ctgatatttt taaaataagt 7500
gaccttgtgt tctttaacca gtccacatct ttagagaaca aaaatgtgtt atgatattat 7560
gggccatgct aatgacctct agaaaacatc agaatatttc tggatattta ataatagctt 7620
tatatatgac taatgctcat ttctatgtaa ttctgtttaa tagttgcttt aaaggtgaat 7680
tttgccacat ttactttgac agcagtataa ggagtgagat agacatgaac ctgaatttca 7740
atttaaaatc atggaagaga gggaaaaaaa accagcttaa gaaaaatcaa ctgataaact 7800
gcaagaaaaa aatgcaactt acatcacaaa agctaattgc tttattattt agagagtact 7860
taaaaattaa agaccaaact tctctccacc caacaaaaat gggcaaagga catacagcta 7920
ggtcaccaag aaagaagggc aaataggtgg tgagtatatg taaagatact tgataggact 7980
tttgcttagt tgaatcttta gcaaatctct tttatttctt gggattttga agaagtaatt 8040
tttaaaggag gactagaaac taagtgattg ggaattggcc tttttagaat taaaatttcc 8100
cattacaaga aaaaaaaatc ctgtgttctt ttttttttcc agaatggagt aggtcagtga 8160
gcaatgtgat taataaatat ttcaatgtct gtgacttttg atttattttg gagacagggt 8220
cttgctctgt tacccaggct ggagtgcagt ggtgctatct aggcttactg caacctcacc 8280
tgtcactttt taattgcaag aaagctgaaa ggtttttttc tattatatca gttataatga 8340
taaatactgt atatactaac tatgagtaaa atactatatt gcctaacttg tattattaag 8400
caattctgct aacctgtgac cttacatttt catctgaaaa gcaggggctg gacaccaatt 8460
gccctatgaa gctattgcta gtcctaacat tctttgtttt gtttgctttt ttggcacact 8520
taagtgtgta ctatgaagtt tatgatgctt taatgaaatt ttctgtctct accattgtaa 8580
tgagaaagga ataaaatact ttattttgca aatctaaaaa aaaaaaaaa 8629
<210> 5
<211> 1676
<212> DNA
<213> Homo sapiens
<400> 5
aagtcataag gtgaaaaagc ctatttcaga gagcacttcc tgaaagagac aaagcagcaa 60
ttaaagtcag cccagcacca actccgacgc caagcgttac actggaaact actttttaaa 120
gcaacaaaag agtctaaaac aaaatacaac atttcttaaa tacactgttt ccagaaagag 180
ctattttaac agaagcaact caaagatatc ccttcgacag aagtggaagt gctgaaaaat 240
gctcatctct cacacagact tttgatggac aggaggtgct gctttctgtg aaccactgaa 300
gtagagcagc tgaaatcaca aaacctggaa gacttggctt tacgtactcc caattgtgca 360
ctagaaaaca gctcatctat tgctctaaca gtctagttct tgatctgctg accatgacac 420
aaaacattgc tgtttctcaa cctatgataa tttaaagaga acataagttt ctaagtatca 480
tgcctaccaa caagctgtaa aatgatcacc ctgaacaatc aagatcaacc tgtccctttt 540
aacagctcac atccagatga atacaaaatt gcagcccttg tcttctatag ctgtatcttc 600
ataattggat tatttgttaa catcactgca ttatgggttt tcagttgtac caccaagaag 660
agaaccacgg taaccatcta tatgatgaat gtggcattag tggacttgat atttataatg 720
actttaccct ttcgaatgtt ttattatgca aaagatgaat ggccatttgg agagtacttc 780
tgccagattc ttggagctct cacagtgttt tacccaagca ttgctttatg gcttcttgcc 840
tttattagtg ctgacagata catggccatt gtacagccga agtacgccaa agaacttaaa 900
aacacgtgca aagccgtgct ggcgtgtgtg ggagtctgga taatgaccct gaccacgacc 960
acccctctgc tactgctcta taaagaccca gataaagact ccactcccgc cacctgcctc 1020
aagatttctg acatcatcta tctaaaagct gtgaacgtgc tgaacctcac tcgactgaca 1080
ttttttttct tgattccttt gttcatcatg attgggtgct acttggtcat tattcataat 1140
ctccttcacg gcaggacgtc taagctgaaa cccaaagtca aggagaagtc cataaggatc 1200
atcatcacgc tgctggtgca ggtgctcgtc tgctttatgc ccttccacat ctgtttcgct 1260
ttcctgatgc tgggaacggg ggagaacagt tacaatccct ggggagcctt taccaccttc 1320
ctcatgaacc tcagcacgtg tctggatgtg attctctact acatcgtttc aaaacaattt 1380
caggctcgag tcattagtgt catgctatac cgtaattacc ttcgaagcat gcgcagaaaa 1440
agtttccgat ctggtagtct acggtcacta agcaatataa acagtgaaat gttatgaata 1500
ataaggttct ttcatttcaa tcccatcaaa attcacttca ctaactactc tggcgtcaat 1560
ggatattctg tataatacta tcaagtccct tttctcttga aaaaataaat tcattatctt 1620
cattttaaaa acttatataa aacatttttg tgaattattc aaaaaaaaaa aaaaaa 1676
<210> 6
<211> 1688
<212> DNA
<213> Homo sapiens
<400> 6
gcagttcttt gaatttctca ccctaagatc tggcctgtac attttcaagg aattcttgag 60
aggttcttgg agagattctg ggagccaaac actccattgg gatcctagct gttttagaga 120
acaacttgta atggagcctt catctcttga gctgccggct gacacagtgc agcgcattgc 180
ggctgaactc aaatgccacc caacggatga gagggtggct ctccacctag atgaggaaga 240
taagctgagg cacttcaggg agtgctttta tattcccaaa atacaggatc tgcctccagt 300
tgatttatca ttagtgaata aagatgaaaa tgccatctat ttcttgggaa attctcttgg 360
ccttcaacca aaaatggtta aaacatatct tgaagaagaa ctagataagt gggccaaaat 420
agcagcctat ggtcatgaag tggggaagcg tccttggatt acaggagatg agagtattgt 480
aggccttatg aaggacattg taggagccaa tgagaaagaa atagccctaa tgaatgcttt 540
gactgtaaat ttacatcttc taatgttatc attttttaag cctacgccaa aacgatataa 600
aattcttcta gaagccaaag ccttcccttc tgatcattat gctattgagt cacaactaca 660
acttcacgga cttaacattg aagaaagtat gcggatgata aagccaagag agggggaaga 720
aaccttaaga atagaggata tccttgaagt aattgagaag gaaggagact caattgcagt 780
gatcctgttc agtggggtgc atttttacac tggacagcac tttaatattc ctgccatcac 840
aaaagctgga caagcgaagg gttgttatgt tggctttgat ctagcacatg cagttggaaa 900
tgttgaactc tacttacatg actggggagt tgattttgcc tgctggtgtt cctacaagta 960
tttaaatgca ggagcaggag gaattgctgg tgccttcatt catgaaaagc atgcccatac 1020
gattaaacct gcattagtgg gatggtttgg ccatgaactc agcaccagat ttaagatgga 1080
taacaaactg cagttaatcc ctggggtctg tggattccga atttcaaatc ctcccatttt 1140
gttggtctgt tccttgcatg ctagtttaga gatctttaag caagcgacaa tgaaggcatt 1200
gcggaaaaaa tctgttttgc taactggcta tctggaatac ctgatcaagc ataactatgg 1260
caaagataaa gcagcaacca agaaaccagt tgtgaacata attactccgt ctcatgtaga 1320
ggagcggggg tgccagctaa caataacatt ttctgttcca aacaaagatg ttttccaaga 1380
actagaaaaa agaggagtgg tttgtgacaa gcggaatcca aatggcattc gagtggctcc 1440
agttcctctc tataattctt tccatgatgt ttataaattt accaatctgc tcacttctat 1500
acttgactct gcagaaacaa aaaattagca gtgttttcta gaacaactta agcaaattat 1560
actgaaagct gctgtggtta tttcagtatt attcgatttt taattattga aagtatgtca 1620
ccattgacca catgtaacta acaataaata atatacctta cagaaaatct gaaaaaaaaa 1680
aaaaaaaa 1688
<210> 7
<211> 1818
<212> DNA
<213> Homo sapiens
<400> 7
ggcgcccgcg cccgcccccg cgccgggccc ggctcggccc gacccggctc cgccgcgggc 60
aggcggggcc cagcgcactc ggagcccgag cccgagccgc agccgccgcc tggggcgctt 120
gggtcggcct cgaggacacc ggagaggggc gccacgccgc cgtggccgca gaaatgacca 180
tggttgacac agagatgcca ttctggccca ccaactttgg gatcagctcc gtggatctct 240
ccgtaatgga agaccactcc cactcctttg atatcaagcc cttcactact gttgacttct 300
ccagcatttc tactccacat tacgaagaca ttccattcac aagaacagat ccagtggttg 360
cagattacaa gtatgacctg aaacttcaag agtaccaaag tgcaatcaaa gtggagcctg 420
catctccacc ttattattct gagaagactc agctctacaa taagcctcat gaagagcctt 480
ccaactccct catggcaatt gaatgtcgtg tctgtggaga taaagcttct ggatttcact 540
atggagttca tgcttgtgaa ggatgcaagg gtttcttccg gagaacaatc agattgaagc 600
ttatctatga cagatgtgat cttaactgtc ggatccacaa aaaaagtaga aataaatgtc 660
agtactgtcg gtttcagaaa tgccttgcag tggggatgtc tcataatgcc atcaggtttg 720
ggcggatgcc acaggccgag aaggagaagc tgttggcgga gatctccagt gatatcgacc 780
agctgaatcc agagtccgct gacctccggg ccctggcaaa acatttgtat gactcataca 840
taaagtcctt cccgctgacc aaagcaaagg cgagggcgat cttgacagga aagacaacag 900
acaaatcacc attcgttatc tatgacatga attccttaat gatgggagaa gataaaatca 960
agttcaaaca catcaccccc ctgcaggagc agagcaaaga ggtggccatc cgcatctttc 1020
agggctgcca gtttcgctcc gtggaggctg tgcaggagat cacagagtat gccaaaagca 1080
ttcctggttt tgtaaatctt gacttgaacg accaagtaac tctcctcaaa tatggagtcc 1140
acgagatcat ttacacaatg ctggcctcct tgatgaataa agatggggtt ctcatatccg 1200
agggccaagg cttcatgaca agggagtttc taaagagcct gcgaaagcct tttggtgact 1260
ttatggagcc caagtttgag tttgctgtga agttcaatgc actggaatta gatgacagcg 1320
acttggcaat atttattgct gtcattattc tcagtggaga ccgcccaggt ttgctgaatg 1380
tgaagcccat tgaagacatt caagacaacc tgctacaagc cctggagctc cagctgaagc 1440
tgaaccaccc tgagtcctca cagctgtttg ccaagctgct ccagaaaatg acagacctca 1500
gacagattgt cacggaacac gtgcagctac tgcaggtgat caagaagacg gagacagaca 1560
tgagtcttca cccgctcctg caggagatct acaaggactt gtactagcag agagtcctga 1620
gccactgcca acatttccct tcttccagtt gcactattct gagggaaaat ctgacaccta 1680
agaaatttac tgtgaaaaag cattttaaaa agaaaaggtt ttagaatatg atctatttta 1740
tgcatattgt ttataaagac acatttacaa tttactttta atattaaaaa ttaccatatt 1800
atgaaattgc tgatagta 1818
<210> 8
<211> 532
<212> DNA
<213> Homo sapiens
<400> 8
gagaaaccag agactgtagc aactctggca gggagaagct gtctctgatg gcctgaagct 60
gtgggcagct ggccaagcct aaccgctata aaaaggagct gcctctcagc cctgcatgtc 120
tcttgtcagc tgtctttcag aagacctggt ggggcaagtc cgtgggcatc atgttgaccg 180
agctggagaa agccttgaac tctatcatcg acgtctacca caagtactcc ctgataaagg 240
ggaatttcca tgccgtctac agggatgacc tgaagaaatt gctagagacc gagtgtcctc 300
agtatatcag gaaaaagggt gcagacgtct ggttcaaaga gttggatatc aacactgatg 360
gtgcagttaa cttccaggag ttcctcattc tggtgataaa gatgggcgtg gcagcccaca 420
aaaaaagcca tgaagaaagc cacaaagagt agctgagtta ctgggcccag aggctgggcc 480
cctggacatg tacctgcaga ataataaagt catcaatacc tcaaaaaaaa aa 532
<210> 9
<211> 2643
<212> DNA
<213> Homo sapiens
<400> 9
gctctaacta tcaaaacact cattttgttt tatagcatga caggctgtct gattccatct 60
ttataaccaa agccaattaa gatcttaaaa ccaaacatat aacttcatct ttttacaagt 120
acttagagcc tgagttgctc cacaggaatc caggaactgg gcacaggaaa aggatctaag 180
ctggtggtgt gggaagatgg aaaccaactt ctccattcct ctgaatgaaa ctgaggaggt 240
gctccctgag cctgctggcc acaccgttct gtggatcttc tcattgctag tccacggagt 300
cacctttgtc ttcggggtcc tgggcaatgg gcttgtgatc tgggtggctg gattccggat 360
gacacgcaca gtcaacacca tctgttacct gaacctggcc ctagctgact tctctttcag 420
tgccatccta ccattccgaa tggtctcagt cgccatgaga gaaaaatggc cttttggctc 480
attcctatgt aagttagttc atgttatgat agacatcaac ctgtttgtca gtgtctacct 540
gatcaccatc attgctctgg accgctgtat ttgtgtcctg catccagcct gggcccagaa 600
ccatcgcacc atgagtctgg ccaagagggt gatgacggga ctctggattt tcaccatagt 660
ccttacctta ccaaatttca tcttctggac tacaataagt actacgaatg gggacacata 720
ctgtattttc aactttgcat tctggggtga cactgctgta gagaggttga acgtgttcat 780
taccatggcc aaggtctttc tgatcctcca cttcattatt ggcttcagcg tgcctatgtc 840
catcatcaca gtctgctatg ggatcatcgc tgccaaaatt cacagaaacc acatgattaa 900
atccagccgt cccttacgtg tcttcgctgc tgtggtggct tctttcttca tctgttggtt 960
cccttatgaa ctaattggca ttctaatggc agtctggctc aaagagatgt tgttaaatgg 1020
caaatacaaa atcattcttg tcctgattaa cccaacaagc tccttggcct tttttaacag 1080
ctgcctcaac ccaattctct acgtctttat gggtcgtaac ttccaagaaa gactgattcg 1140
ctctttgccc actagtttgg agagggccct gactgaggtc cctgactcag cccagaccag 1200
caacacagac accacttctg cttcacctcc tgaggagacg gagttacaag caatgtgagg 1260
tcggggatat ttttgggctc tgtctctttc taccctgcgt taagcggaaa aaaaaaattc 1320
tgacagtgtt tttcttcctc tttcatacca ccaccaccac aatcatcaac ataaaggaag 1380
tctgtaccaa atctgtaggg ggtttttccc acaaccaagc aatagacacc agctgggtgt 1440
cctacaatta aattccaaca ctatctacct ggagctactg tcagatccca caggtttaag 1500
ggctcattcc ccaagtctgc tcctccagtt gagacacaag tcacaaatcc aggcttctga 1560
aacttcggac caaccagctt caatcagggt tcccactacc ccctctttgg gggtagagtg 1620
gctcatggaa ctcagagaaa catttatttc ggcttgctgg tttattataa aagcaaggtt 1680
tattataaaa gatactacaa aggatacaga tgaagaggca catagggcaa ggtacggggt 1740
tccacgccct ccctgagtgc atcaccctct gggaacctcc gtgtgttcac gtctcatgaa 1800
gctctccaaa tccagtcctc ttgggttttt atggaagctt catgatgtca gcattctttc 1860
ctccagtgta taggatggga tcctctctgg ggagggtctt aagacccaca attagaaagg 1920
caagggaaga ttagagtcct gctttggggt agatgaaagg aaaggagaga gattctgttt 1980
cctgaggctt aatacaccca acattataac aaaggactgt agcaagggct atgggagttc 2040
tgaagcagaa accatgggct aaaaccaaca tacatcttaa taccagatac cctaatccca 2100
gtcctaactt catttaacct tggtcacatt gagtcattcc aggatgagtg gctcaagtat 2160
ttcctcaggg aaaatacttc tgtgccccct gatttgaggg taagaagtag ataatgaggc 2220
cactgtgggt gttatttttt catgtctgga cctcagccta tatcctgaga ctaagtggaa 2280
gtgggaaaag agtacaagag aagagacaaa gtggggatat ttgtaaggct tagatgagat 2340
agtgtttttt tagaaaaaaa ctttatctta ccattaagta aaatgtttgc cataggcttt 2400
ctggggcttt ctctttttaa agtcagactg ttgaaggttt cttctattct tatttgttaa 2460
gagttttctt ttattgttta aatcatgaat gaatgttgaa ttttattaaa tgcagtttct 2520
gtaaatatta acgtgatcat attattttta ttctttcatt tacataatta taaattagat 2580
taagttttca atgttaagct acccttgcat ttatgaaata aaccacgctt gctcatgaaa 2640
aaa 2643
<210> 10
<211> 2840
<212> DNA
<213> Homo sapiens
<400> 10
atgacaagaa ggacccagcc tccgagcggc cacaccctgt gtgtctctct gtcctgccag 60
cactgagggc tcatccctct gcagagcgcg gggtcaccgg gaggagacgc catgacgccc 120
gccctcacag ccctgctctg ccttgggctg agtctgggcc ccaggacccg catgcaggca 180
gggcccttcc ccaaacccac cctctgggct gagccaggct ctgtgatcag ctgggggagc 240
cccgtgacca tctggtgtca ggggagcctg gaggcccagg agtaccaact ggataaagag 300
ggaagcccag agccctggga cagaaataac ccactggaac ccaagaacaa ggccagattc 360
tccatcccat ccatgacaca gcaccatgca gggagatacc gctgccacta ttacagctct 420
gcaggctggt cagagcccag cgaccccctg gagctggtga tgacaggatt ctacaacaaa 480
cccaccctct cagccctgcc cagccctgtg gtggcctcag gggggaatat gaccctccga 540
tgtggctcac agaagggata tcaccatttt gttctgatga aggaaggaga acaccagctc 600
ccccggaccc tggactcaca gcagctccac agtggggggt tccaggccct gttccctgtg 660
ggccccgtga cccccagcca caggtggagg ttcacatgct attactatta tacaaacacc 720
ccctgggtgt ggtcccaccc cagtgacccc ctggagattc tgccctcagg cgtgtctagg 780
aagccctccc tcctgaccct gcagggccct gtcctggccc ctgggcagag cctgaccctc 840
cagtgtggct ctgatgtcgg ctacgacaga tttgttctgt ataaggaggg ggaacgtgac 900
ttcctccagc gccctggcca gcagccccag gctgggctct cccaggccaa cttcaccctg 960
ggccctgtga gccgctccta cgggggccag tacaggtgct atggtgcaca caacctctcc 1020
tccgagtggt cggcccccag tgaccccctg gacatcctga tcacaggaca gatctatgac 1080
accgtctccc tgtcagcaca gccgggcccc acagtggcct caggagagaa catgaccctg 1140
ctgtgtcagt cacgggggta ttttgacact ttccttctga ccaaagaagg ggcagcccat 1200
cccccactgc gtctgagatc aatgtacgga gctcataagt accaggctga attccccatg 1260
agtcctgtga cctcagccca cgcggggacc tacaggtgct acggctcacg cagctccaac 1320
ccccacctgc tgtctttccc cagtgagccc ctggaactca tggtctcagg acactctgga 1380
ggctccagcc tcccacccac agggccgccc tccacacctg gtctgggaag atacctggag 1440
gttttgattg gggtctcggt ggccttcgtc ctgctgctct tcctcctcct cttcctcctc 1500
ctcctccgtc agcgtcacag caaacacagg acatctgacc agagaaagac tgatttccag 1560
cgtcctgcag gggctgcgga gacagagccc aaggacaggg gcctgctgag gaggtccagc 1620
ccagctgctg acgtccagga agaaaacctc tatgctgctg tgaaggacac acagtctgag 1680
gacagggtgg agctggacag tcagagccca cacgatgaag acccccaggc agtgacgtat 1740
gccccggtga aacactccag tcctaggaga gaaatggcct ctcctccctc ctcactgtct 1800
ggggaattcc tggacacaaa ggacagacag gtggaagagg acaggcagat ggacactgag 1860
gctgctgcat ctgaagcctc ccaggatgtg acctacgccc agctgcacag cttgaccctt 1920
agacggaagg caactgagcc tcctccatcc caggaagggg aacctccagc tgagcccagc 1980
atctacgcca ctctggccat ccactagccc ggggggtacg cagaccccac actcagcaga 2040
aggagactca ggactgctga aggcacggga gctgccccca gtggacacca gtgaacccca 2100
gtcagcctgg acccctaaca cagaccatga ggagacgctg ggaacttgtg ggactcacct 2160
gactcaaaga tgactaatat cgtcccattt tggaaataaa gcaacagact tctcaacaat 2220
caatgagtta ataacaaaaa aacaaaaaac aaaaacagac gtaaaggccg ggtgtggtac 2280
tcaggaggct gagtggggag gattccttga acacaagaag ttaaggctgc tgaggctgca 2340
gtgagctatg actgtgccac tgcactccag cctgtgtgac agagcgagac cttgtctcta 2400
aaaaaaaaaa cagtgaatgt tttaaactga atgataatgt aaatattata catcgaactt 2460
atgacatggg aaaattaaga agcataaata ggccgggcgc ggtggctcac gcctataatc 2520
tcagcacttt gggaggctga tgcgggcgga tcatgaggtc aggagatcga gaccatcctg 2580
gctaacacgg tgaaaccccg tctctactaa aaatacaaaa aaattagccg ggcgtggtgg 2640
cgagtgccta tagtcccagc tactcaggag gctgaggcag gagaatggca tgagcccggg 2700
aggcagagct tgcagtgagc tgagatcgca ccactgcact ccagcctggg cgacagagtg 2760
agattccgtc tcgaaaaaaa aaaaaaaaga aagaaaaaaa ataaaaaaga agcataacca 2820
ggaaaaaaaa aaaaaaaaaa 2840
<210> 11
<211> 1013
<212> DNA
<213> Homo sapiens
<400> 11
cttttgccaa tggcaaccag cagagcttcc cctgaagatt ggaggggatg agtcaggggc 60
aaggaaggat taacagattc tgcctcaagt cctggtgaac caactcctct ccccaagaca 120
gacacatact agtgaaataa attggattta aatcatcacc tgaggcaatc ctgaaagaga 180
aaagcagtcc tagaaaagag tggaggaaaa gaggacagcc ccattctctt tgtgaccacg 240
aagactgccg ccatgtggtt gggagccacg taacttcttt tagtgccagc tgagattctt 300
ctgccctgga actagttcct ccgagttatt gccaggcctg gagattgaat tcctgcagct 360
ggaaggtggg gaaagcaaaa tgttgtgagc acctaccata tgccaggcac tgttcagtga 420
actggttgta caggagtgaa tgagatcatc ttgattttga gaagtttata atctactcaa 480
gggaaacacg tgtaatcaac tatgtttcag acataacccc tcaaaaccaa agcagaacct 540
cttcaaggag ctgagagatg caagcctgga ggagaaaagc ggggcagcat caaacccctc 600
ccactggggc aacctgctga gcatctccct ggccttggcc cctggccata ccacacaagt 660
gtccaatgag tcactgatcc tgaagaacaa gagaagactg accacagacc ccaaaaggaa 720
gcaggagtac aaccttcgaa gttggtgggc aacaagaggt cagaggttga caagcatcca 780
cacagctcta agactagcat catgtggcta cccaggacct gggagagtgc tgcagagcag 840
gagcaggaaa gggaccggct gttcccatag aacttcatgt cacaggtctg ggagccaggg 900
ggccttggtt ctagtcccaa ctctccctct aagttgtctt atggccacag gtgagtgaaa 960
tagcttctct ggcctcagct tcctcacgat taaaatgaca cagttgtgca aaa 1013
<210> 12
<211> 9540
<212> DNA
<213> Homo sapiens
<400> 12
agtgcatgaa gtatgctcag tgtgccagca agggctgata atcagcagaa ggacagggtg 60
cttcgttagt cagaagagcc agggcttccc ggctgccagg ctacagaact cgcctcgcca 120
ctcctgagac atggacaacg ccgttgacgg actggacaaa gcttctatag caaactcaga 180
tggccccaca gcaggttccc aaacacctcc cttcaaaaga aaggggaaac tatccaccat 240
tggtaaaatc tttaagcctt ggaaatggag gaaaaagaag accagcgaca aatttagaga 300
aacctcggca gtattagaaa ggaagatatc cacacgacaa agtagagagg agctgataag 360
aaggggagtg cttaaggaat tgcctgatca agatggagat gtaacagtta actttgaaaa 420
ttcaaacggg cacatgatac ccatcggaga ggaatctacc cgagaggaaa atgtagtaaa 480
gtctgaagaa ggtaatggct ctgtatctga aaaaacacca cctctggagg aacaggcaga 540
agataagaaa gagaacactg aaaaccactc tgaaacaccg gcagctcctg ctctacctcc 600
ttctgctcct cctaagccta gacccaaacc taaacccaaa aaatcacctg tgcctccgaa 660
aggggccact gctggggcca gccacaaagg tgatgaagtg cctcccatta aaaaaaatac 720
caaggctcct ggtaagcagg cccccgtccc tccacccaag ccagcaagcc gaaacacgac 780
ccgagaggct gctggctcct ctcattcaaa aaaaacaact ggctctaaag catcagcttc 840
gccatccact tcatccacct catctcgtcc caaagcttca aaggagacag tttctagcaa 900
agcagggaca gtggggacca ccaagggcaa gagaaaaact gacaagcagc caataacttc 960
tcacctgtcc tcagacacaa caacttctgg cacatccgac ctgaaaggag agcctgcaga 1020
gaccagagtg gagagtttca aactcgaaca gactgtccct ggagctgagg agcagaacac 1080
aggcaaattc aagtccatgg tccctccacc ccctgtggct ccagcacctt ctcctctggc 1140
cccccctctc cctcttgagg atcagtgcat tactgcctca gacactccag ttgtcctcgt 1200
cagcgttgga gctgacctgc ccgtctctgc cttagaccca agtcagcttc tttgggctga 1260
agagccgacg aacagaacca ctctctactc aggcactggc ttaagtgtta acagagaaaa 1320
tgcaaaatgt ttcacaacca aagaggagct ggggaagaca gtgcctcagc tactgactcc 1380
tgggctgatg ggcgaatctt cagaatcctt tagtgcctca gaagatgaag gccacaggga 1440
ataccaagcc aatgactctg actcggacgg gcctatcttg tacaccgatg atgaggacga 1500
agacgaagat gaggatggca gtggagaaag tgctttggca agtaaaatac gccggaggga 1560
tactcttgct atcaaacttg gcaacagacc atctaagaaa gaactagagg acaaaaacat 1620
cttgcagcgt acatctgaag aagagaggca ggaaatccga caacaaattg gaaccaagtt 1680
agtcaggagg ctgagccaga ggcccacaac tgaagaatta gagcaaagaa acatcctaaa 1740
acaaaagaat gaagaagagg aacaagaagc aaaaatggaa cttaaacgca gactcagcag 1800
aaagctcagc ctgagaccca cagtggcaga gctacaagct cgaaggatcc tgcgatttaa 1860
cgagtatgta gaagtcacgg attctcctga ctatgaccgc cgagcagaca agccctgggc 1920
caggttaaca cctgcagaca aggcagcaat aaggaaagaa ctaaatgaat ttaaaagcac 1980
agaaatggaa gttcatgaag agagtcgaca gtttacaagg tttcatcgtc cataacgaag 2040
agtgagacta tttggaaaca gagactgatc atctttgggg gaagccctgc ttcctgaaaa 2100
cctgatattg cactgggatt tgaatgtgtg tgtttccgtt taacttgtgg tgaaggaagt 2160
gtgtgactca gcttggctgg gaagtgctcc tcacctgtgt ggcccagatg gctccaacaa 2220
gcaaaaggaa ggatgcagtg actcttgctg cccagaatgc acagcgatgg taagagacac 2280
cgtggatatt cttcatcaga agctttaatc aaagaagatg agcagaagac aatcactggc 2340
tccctgttac cagaaagcca aattttataa tgcgggtgaa agaaaaatat agattaaaat 2400
tgctgggcac tgaaaagggg tgggagttgg aaatcagaaa gaaagagaaa tatttcatta 2460
tgttaatgaa gaaaagagaa aattgaagca taaatgtatt tttgaagtag ttattcggta 2520
gctgagaact tattaaggga tttaggaatt taacctcctg atgtggattc ctcaaagact 2580
tgatcggaga atactcttgt ttcaccatta tgttggtaca gtatagtacc attattttat 2640
gttgtgccag tgaatccagt tgccagaaat aagtctgaat gttttcatgc atctttttct 2700
taaatgcaag agcttctact gactcttaac aagcatgctt acccaaattt tgttgcatgc 2760
ttttaagtag cattagctat gcacacttga catttttaaa tatccctttc ctagtgtacc 2820
agccttcaca ggataagagg actgggaata aagtcagatg taatgtgacc ctagaaaact 2880
gtagcaagct tcagaaataa atcttttgat ctttccctat cttgattaga tccaaagtca 2940
aagcaaccat acttcaccta gagaagacag tattggcaat catgacacct gtaataaaaa 3000
cttgaatcca aagtcaaaac ttaagcaaga tacaaatgtg ctgcctgcag ttagtcctgc 3060
atgggaataa ggactagtta tttttttagt gctgcatttt tttaaagttg gattgctgct 3120
atttaaaaaa aaaaaaagga cacagatcaa aaaaacaccc aaaggcttaa cagaacatgg 3180
aaagttccca ctaagttgtg tgtgaggaaa tcctcatctt gtattttaag aatctgcaga 3240
tggcatccat agatacagta cagtatttac tgtcaatgca aaagaatcag tgaggttaaa 3300
gtagtggaag ttttccctat gagcctacag tctgtattgt ttacattaag aaactctcta 3360
ttattgtgtt gctattttcc atggagtcac aggcacacta tgacttctgc tcccaaatac 3420
atatgaccat atgtaaatac caccttgcat ttcattgttc ttcacaagtg ctttgtgccc 3480
ctttaattaa aaacacatga aatgaataac aaaacaagac ccaaatagag tttattttat 3540
tctcagagtt tggactacaa ttttctaaga tgtttctggt tcaagactgt cattttctat 3600
ttcaaccgaa aagtaagcat ttaacccggt gaataaatgt agatcctgcc attcattggt 3660
attttaaaga accacttgaa atcggatcat tttatttaaa aataaaaaat gttaatgcca 3720
gttggcctac tataaaaagc caggaccatg ttagaattag gaaaagtaac cagcattact 3780
gcacctcttg ttagactctg tgcattaata aaacacacct agagtctgtt gtcatttcac 3840
taataggata agacaaattt tttgctttga aaaaattttt ctgcatgccc aggtgtctgt 3900
ctctggctga ggttttgtct attttacagt gtttcaatcc agccataaaa attaacttgt 3960
gatttttttt ttcccaaagt catgcttttc cttaattata tttttatttt attattttag 4020
tgtcttgaga aaaataccaa gagatataat gtttctttta attgtctatg cttaatcatc 4080
tttaaacact ttttaaattt ctaaccacaa gacctctcta taatggtaaa tgtaagacat 4140
caccatttta tcactcaaag tatgttattg aaagtttcta tttggttgat aaaaggaaca 4200
attttttccc acttttgatg cctgtgatgc aattttttat tgcctacaat gagatacact 4260
tagtacaaaa aatgaaaatc tggtatttca aaattgcatt tcttgtataa taggtcagat 4320
ttattaacta ctcatacttt ttctttacac taatcgatac atttagaaaa aattttctaa 4380
gttagagaca agtttaaaag taaaaaaaaa aaaaaattag ccactgctag tctactgttt 4440
aggtaatcgg aatcaccaat tattttatta gaatgatggc ttgagtaaaa agctgtggaa 4500
agaattaaag gattatgagc taagctgtat tttgcagaat atggttctat tttagtagag 4560
cagagatgag acatatcccc accggccacc cagccagagg tctcctacct gggggcccta 4620
aagggatgca gaggtctggc ccaccctccg tgcataggca cctctgtcca ccaccagcgt 4680
ttcagcaatc caaccagtaa gcatatgctg tataggaaaa ataaaagtgt gtgggaattg 4740
gatttctttt gttgtaacac aattccaggt ttttggctat ttaaagtttg acattaggct 4800
gacatcgagg aagtaagtgg gttttcctga gttcccaaga tatgattaag gaagaaaaca 4860
aacccatctc caggaagatc ccaggcagga aagaactaga cagatgtaga aaccaaagtg 4920
accattttag tttttttatt ggagaataaa acattaatat tagggtatta agaagatgct 4980
cagcaagctt gatcagaatc ttcatggtca ttaccaatca gtctgacaaa atagttctct 5040
ggtagtcagc attcatttaa ggcagcttgc ctgataattt cctgtgttat gtgaagtgtc 5100
ttgcactttc acatgttagc tataattcct taaattactt aactgaaatc tgtaatagag 5160
aaccattttg gcatttgaac agctatttta catggagaaa aagcaaacac atctgtttgc 5220
tttacccaga aaaactgact ttctggtttc atcttcatat tgtttagtag cataatgaga 5280
gtagtccttt atctttctct aatgttagta aatatattct gttagtagga agttctgaaa 5340
ttgaagggaa aatatattta aggaaataaa ggaattcaat acacccttca aaagtcacca 5400
aatactgaaa ataagagatg agtccttaaa acctgagtca aaaaaggtcc agttttacag 5460
cctgcaatta attcagggct gcgttggcat taaaaaagaa aatatatata tatatatata 5520
tatatatata tatatatata tatatgtata ttatatatac agtagcttac acttaaaaga 5580
ggaaaaattt gcattaacat tgcatattct gatatgtacc atattaacac ataacaggca 5640
ttttatttat gcttcataga atcagacaga cacaactttc aaaaatctta ctgtattcac 5700
aatagaaaag ggtagtcttg tctaccacag aggagtatgt ccacacttaa taatgaaaac 5760
tttcttcctt tcctgcccaa aaatttcttc agtctgttat tatttttaag tgccccttgc 5820
tgcaaatttc aaacagagca agaaatcttc ctcagagtag gtggtatgaa attaaactag 5880
tacaatatat atgaattcat gtcatttacc cctgagtatg gtagaattgt taaagcattc 5940
ttaaattcca attatatgaa gcctatcatt actaggaaaa gtatattctt tgggataaga 6000
attaatttct tcacactatt agagcatgtt gtgagtagta aggaactact tagatgcaat 6060
ttatttacag aattgtccct tgacctcttg aaatggctag atctttcact actgtgtagg 6120
tagtctctac ttactggtag gatagattac attgctttac tggacaaagc agaatgaact 6180
tatataacta aaatatgtcc tatattggct gggtgcggtg gcttacacct gtaataccag 6240
cactttggga ggccaaggtg ggtggatcag ttgaggtcag gagttcgaga ccagcctggc 6300
caacatggtg aaaccctgtc tctactgaaa atacaaaaaa aaaaaagtat ctgggcatgg 6360
tggcttgtgc ctgtaatccc agctacttgg gaggctgagg cagggaaatc gcttaaaccc 6420
gggaggtgga ggttgcagtg ggcccagatc gtgccactcc actccagcct gggagacaga 6480
gcaagactcc atctcaaaat aataataata gtaataatga ataaaataaa ataaaatatg 6540
tcctccaggg aaaagcaatg acagagtaat caccaaatta ataggaacat ctttctagag 6600
aaagtacatg cccagttagt tcaaacccag gtttcaaaga agtagcactg ggctctactg 6660
taaaggcagg cagtgaccaa gaggtggtgg ggagagaggt agagtaccct caaatcattc 6720
ccattttcac ttccaatttc ccttttgtaa tcattaagct taagctatgt atggaaatgc 6780
aaagcaccat tagcatttct agaaagcagc tggaacctta cccaccaatg cttttttgaa 6840
gacagtatca tcccaaattt aaaaatccta ttgtatatgt tgtaaaattt ctggcaaaga 6900
aatggaggat cctgtggcag ctattcccac ctaaagccaa ccctataagg atgggtcatt 6960
ttttagccat gctaggattt actgcacaca caaaaaatgt catttagctt gtcacattgc 7020
tagcacagct gcacatatga gcaaagcact gttggtctgt gtttctcagt gggggtactc 7080
ttggcatttg gagctggata ggtctttgct gtacagaatc atcccatgca ttgccagatg 7140
tttaatatcc caggcccctg ctgactaaat gtcagtagca ttctcagtca ttgtaaacac 7200
caagaataaa aagcattccc ccaggttcaa atgccctccc tgggaggttg gtatcacctc 7260
ccctgaatgc cactgtctac tgcattttga ggacacaggg agaaaaagtg cctatcctca 7320
aacattgtct ctgctgcctt gcatttcttt gggccctgaa tggtttttct cccttcattt 7380
ttcgagcctt tctctcagtg cagctgttct tcagggagga ggttactggg cagccttggc 7440
cattcagtgg gcatggggac ttggcctagt ccctatatat atatacttaa agtccctata 7500
tatacttaaa ggagagatca tacatgaaga aagctttttt tttttttttt ttttttgcct 7560
tacaactttt ctttagaacc acattattgg tcataatcct tgttactgtc atgaggattg 7620
ttgcatgggt taaacacaaa cacagactag caatgcactt gaacaaacct ggtggtcttt 7680
ggaaataaat caccattaga tttcacctgg ttatgctgca tcccataagt tccaaatgaa 7740
tcacctgctt atcctattaa cgaagcattt aattcacaca caaatgcttg aatttcccct 7800
gtataaatgt agtcatgcga ttcaactttt ctaataagat ttgtgaatgc tgcatcatga 7860
tgaaaatgtg gattaactgt gggttgcatg cctgttgttc atacttcagt gatggtcaca 7920
cacaaaacaa gatgagtttt acttaggtga aacattatta aactgtacta acaatacaga 7980
aacatattct ctttgtcgct ttttatcacc aaaactgaat ggcaaatatg tcttgacatt 8040
acttggatga actgtggcta gcaaaatgga attaacttag ccactataat tttttaaaac 8100
attaaagttt ctaaattgtt tttggggccg agtaacgcag agtcaataaa ggtggttata 8160
ttgtaagctt ttagatggtg cttaagaatt cttatctttt taaatagcag tatttttttt 8220
ttaagaataa attgtaagga gcaaataagg cagaatgcca ctctaccctc aggtcaattt 8280
tatggtatat gaaaatgcca gtaatatttg tgccacttgc caactcgggg gaggaggggc 8340
ttttccctta ctggatactt ttgttatagt ttgactatgt cattatgttg tttagagagc 8400
ctccacaatg agaagttgcc actgcagggc taactcgcct tcagaaataa tcagaatgat 8460
tcaagggtca aaccactttc atcccttaaa atatagggac taatatttct ttttcttttt 8520
tttaaaaaaa acatttcttc tgtggcttag aaatgtgcca gtgtgttcaa aacatttaca 8580
ccaatttcac cagatttagg acctattaaa aattcaaaca agtttctttt tttttttttt 8640
ttttctgtgt aacagggatt tttaaataac ggactatatg cattcttttg ttatttcaca 8700
cttcagttaa agtgataaca atggtaaact gtgatcatta tcagactgac tgaatgcttt 8760
ctgatttcca gtgagtgatc tagttctacg tattacacag gtgtaatatc tgtgagtgta 8820
aataactgga actgtacact gattaacatg acagtttctc ttttgttgtt cttatctgta 8880
ctgtattata gtatgtgggt ataaatatct acaagtatac acacatatgt acttgtattc 8940
cactattgta acctgaaaga aagactatgt attccctttt ttaattccgt actggtattt 9000
gtgttattta aaaagcaaaa ttctgctcta tttagttgta taatattaga ggatactttg 9060
ctgtgcacaa ttccaagtgc cttagaacat tgtttagctt tcctaagtat atataaatgc 9120
atatatgtat aaaattggga aaagttacct caataaaatc attgggaaat ccccagtttt 9180
agtttgttcc agtttctctt atatttggat agtgctcagc ctttttaaat gaaaaaagaa 9240
aaaagagtaa gacaacttcc ctaattgcct gttatttcag cttcacctaa gtttttaaca 9300
cctctttgta tgtaaggtct tgagacatgt aaggcctggt actttttatt taaaatgtct 9360
gtctaaagaa ttactgctct taaaagaaac ttccagtatt ttttttaact tgctatcttt 9420
ttatgtctga ggtatttgat attgatgttt ttattgccat tattatatgt aaacataaaa 9480
gatagtccat ttagagttta taatatagaa aataaacaga cttcctcatt aaaaaaaaaa 9540
9540
<210> 13
<211> 1290
<212> DNA
<213> Homo sapiens
<400> 13
ggctgagcct ataaagcggc aggtgcgcgc cgccctacag acgttcgcac acctgggtgc 60
cagcgcccca gaggtcccgg gacagcccga ggcgccgcgc ccgccgcccc gagctcccca 120
agccttcgag agcggcgcac actcccggtc tccactcgct cttccaacac ccgctcgttt 180
tggcggcagc tcgtgtccca gagaccgagt tgccccagag accgagacgc cgccgctgcg 240
aaggaccaat gagagccccg ctgctaccgc cggcgccggt ggtgctgtcg ctcttgatac 300
tcggctcagg ccattatgct gctggattgg acctcaatga cacctactct gggaagcgtg 360
aaccattttc tggggaccac agtgctgatg gatttgaggt tacctcaaga agtgagatgt 420
cttcagggag tgagatttcc cctgtgagtg aaatgccttc tagtagtgaa ccgtcctcgg 480
gagccgacta tgactactca gaagagtatg ataacgaacc acaaatacct ggctatattg 540
tcgatgattc agtcagagtt gaacaggtag ttaagccccc ccaaaacaag acggaaagtg 600
aaaatacttc agataaaccc aaaagaaaga aaaagggagg caaaaatgga aaaaatagaa 660
gaaacagaaa gaagaaaaat ccatgtaatg cagaatttca aaatttctgc attcacggag 720
aatgcaaata tatagagcac ctggaagcag taacatgcaa atgtcagcaa gaatatttcg 780
gtgaacggtg tggggaaaag tccatgaaaa ctcacagcat gattgacagt agtttatcaa 840
aaattgcatt agcagccata gctgccttta tgtctgctgt gatcctcaca gctgttgctg 900
ttattacagt ccagcttaga agacaatacg tcaggaaata tgaaggagaa gctgaggaac 960
gaaagaaact tcgacaagag aatggaaatg tacatgctat agcataactg aagataaaat 1020
tacaggatat cacattggag tcactgccaa gtcatagcca taaatgatga gtcggtcctc 1080
tttccagtgg atcataagac aatggaccct ttttgttatg atggttttaa actttcaatt 1140
gtcacttttt atgctatttc tgtatataaa ggtgcacgaa ggtaaaaagt attttttcaa 1200
gttgtaaata atttatttaa tatttaatgg aagtgtattt attttacagc tcattaaact 1260
tttttaacca aacagaaaaa aaaaaaaaaa 1290
<210> 14
<211> 815
<212> DNA
<213> Homo sapiens
<400> 14
agaggagcag aggggctgag accaaaccag aaacctccaa ttctcatgtg gaagcccatg 60
ccctcaccct ccaacatgaa agcctctgca gcacttctgt gtctgctgct cacagcagct 120
gctttcagcc cccaggggct tgctcagcca gttgggatta atacttcaac tacctgctgc 180
tacagattta tcaataagaa aatccctaag cagaggctgg agagctacag aaggaccacc 240
agtagccact gtccccggga agctgtaatc ttcaagacca aactggacaa ggagatctgt 300
gctgacccca cacagaagtg ggtccaggac tttatgaagc acctggacaa gaaaacccaa 360
actccaaagc tttgaacatt catgactgaa ctgaaaacaa gccatgactt gagaaacaaa 420
taatttgtat accctgtcct ttctcagagt ggttctgaga ttattttaat ctaattctaa 480
ggaatatgag ctttatgtaa taatgtgaat catggttttt cttagtagat tttaaaagtt 540
attaatattt taatttaatc ttccatggat tttggtgggt tttgaacata aagccttgga 600
tgtatatgtc atctcagtgc tgtaaaaact gtgggatgct cctcccttct ctacctcatg 660
ggggtattgt ataagtcctt gcaagaatca gtgcaaagat ttgctttaat tgttaagata 720
tgatgtccct atggaagcat attgttatta tataattaca tatttgcata tgtatgactc 780
ccaaattttc acataaaata gatttttgta taaca 815
<210> 15
<211> 1921
<212> DNA
<213> Homo sapiens
<400> 15
gaagcacaca ggaaaaggag cttagctgct ggtgctgctg gcaagatgga aaccaacttc 60
tccactcctc tgaatgaata tgaagaagtg tcctatgagt ctgctggcta cactgttctg 120
cggatcctcc cattggtggt gcttggggtc acctttgtcc tcggggtcct gggcaatggg 180
cttgtgatct gggtggctgg attccggatg acacgcacag tcaccaccat ctgttacctg 240
aacctggccc tggctgactt ttctttcacg gccacattac cattcctcat tgtctccatg 300
gccatgggag aaaaatggcc ttttggctgg ttcctgtgta agttaattca catcgtggtg 360
gacatcaacc tctttggaag tgtcttcttg attggtttca ttgcactgga ccgctgcatt 420
tgtgtcctgc atccagtctg ggcccagaac caccgcactg tgagtctggc catgaaggtg 480
atcgtcggac cttggattct tgctctagtc cttaccttgc cagttttcct ctttttgact 540
acagtaacta ttccaaatgg ggacacatac tgtactttca actttgcatc ctggggtggc 600
acccctgagg agaggctgaa ggtggccatt accatgctga cagccagagg gattatccgg 660
tttgtcattg gctttagctt gccgatgtcc attgttgcca tctgctatgg gctcattgca 720
gccaagatcc acaaaaaggg catgattaaa tccagccgtc ccttacgggt cctcactgct 780
gtggtggctt ctttcttcat ctgttggttt ccctttcaac tggttgccct tctgggcacc 840
gtctggctca aagagatgtt gttctatggc aagtacaaaa tcattgacat cctggttaac 900
ccaacgagct ccctggcctt cttcaacagc tgcctcaacc ccatgcttta cgtctttgtg 960
ggccaagact tccgagagag actgatccac tccctgccca ccagtctgga gagggccctg 1020
tctgaggact cagccccaac taatgacacg gctgccaatt ctgcttcacc tcctgcagag 1080
actgagttac aggcaatgtg aggatggggt cagggatatt ttgagttctg ttcatcctac 1140
cctaatgcca gttccagctt catctaccct tgagtcatat tgaggcattc aaggatgcac 1200
agctcaagta tttattcagg aaaaatgctt ttgtgtccct gatttggggc taagaaatag 1260
acagtcaggc tactaaaata ttagtgttat tttttgtttt ttgacttctg cctataccct 1320
ggggtaagtg gagttgggaa atacaagaag agaaagacca gtggggattt gtaagactta 1380
gatgagatag cgcataataa ggggaagact ttaaagtata aagtaaaatg tttgctgtag 1440
gttttttata gctattaaaa aaaatcagat tatggaagtt ttcttctatt tttagtttgc 1500
taagagtttt ctgtttcttt ttcttacatc atgagtggac tttgcatttt atcaaatgca 1560
ttttctacat gtattaagat ggtcatatta ttcttcttct tttatgtaaa tcattataaa 1620
taatgttcat taagttctga atgttaaact actcttgaat tcctggaata aaccacactt 1680
agtcctgatg tactttaaat atttatatct cacaggagtt ggttagaatt tctgtgttta 1740
tgtttatata ctgttatttc actttttcta ctatccttgc taagttttca tagaaaataa 1800
ggaacaaaga gaaacttgta atggtctctg aaaaggaatt gagaagtaat tcctctgatt 1860
ctgttttctg gtgttatatc tttattaaat attcagaaaa attcaccagt gaaaaaaaaa 1920
a 1921
<210> 16
<211> 2152
<212> DNA
<213> Homo sapiens
<400> 16
ttcgtagttt cctgataacc attcagtcat ctatttcaac accctgacat gacataaagg 60
caggcacgga accacacgtt caccatacag acacacgcca ctttgctgga gcattcacta 120
ggcgaggcgc tccatcggac tcactagctg cactcatgaa tcggcaccat ctgcaggatc 180
actttctgga aatagacaag aagaactgct gtgtgttccg agatgacttc attgccaagg 240
tgttgccgcc ggtgttgggg ctggagttta tctttgggct tctgggcaat ggccttgccc 300
tgtggatttt ctgtttccac ctcaagtcct ggaaatccag ccggattttc ctgttcaacc 360
tggcagtagc tgactttcta ctgatcatct gcctgccgtt cgtgatggac tactatgtgc 420
ggcgttcaga ctggaagttt ggggacatcc cttgccggct ggtgctcttc atgtttgcca 480
tgaaccgcca gggcagcatc atattcctca cggtggtggc ggtagacagg tatttccggg 540
tggtccatcc ccaccacgcc ctgaacaaga tctccaattg gacagcagcc atcatctctt 600
gccttctgtg gggcatcact gttggcctaa cagtccacct cctgaagaag aagttgctga 660
tccagaatgg cactgcaaat gtgtgcatca gcttcagcat ctgccatacc ttccggtggc 720
acgaagctat gttcctcctg gagttcttcc tgcccctggg catcatcctg ttctgctcag 780
ccagaattat ctggagcctg cggcagagac aaatggaccg gcatgccaag atcaagagag 840
ccatcacctt catcatggtg gtggccatcg tctttgtcat ctgcttcctt cccagcgtgg 900
ttgtgcggat ccacatcttc tggctcctgc acacttcggg cacgcagaat tgtgaagtgt 960
accgctcggt ggacctggcg ttctttatca ctctcagctt cacctacatg aacagcatgc 1020
tggaccccgt ggtgtactac ttctccagcc catcctttcc caacttcttc tccactttga 1080
tcaaccgctg cctccagagg aagataacag gtgagccaga taataaccgc agcacgagcg 1140
tcgagctcac aggggacccc aacaaaacca gaggcgctcc agaggcgtta atcgccaact 1200
ccggtgagcc atggagcccc tcttatctgg gcccaacctc aaataaccat tccaagaagg 1260
gacattgtca ccaagaacca gcatctctgg agaaacagtt gggctgttgc atcgagtaat 1320
gtcactggac tcggcctaag atttcctgga acttccagat tcagagaatc tgatttaggg 1380
aaactgtggc agatgagtgg gagactggtt gcaaggtgtg accgcaggaa tcctggagga 1440
acagagagta aagcttctag gcatctgaaa cttgcttcat ctctgacgct cgcaggactg 1500
aagatgggca aattgtaggc gtttctgctg agcagagttg gagccagaga tctacttgtg 1560
acttgttggc cttcttccca catctgcctc agactggagg gggctcagct cctggggtga 1620
tatctagcct gcttgtgagc tctagcaggg ataaggagag ctgagattgg agggaattgt 1680
gttgttcctg gaggaagccc aggcatcatt aaacaagcca gtaggtcacc tggcttccgt 1740
ggaccaattc atctttcaga caatctttag cagaaatgga ctcagggaag agactcacat 1800
gctttggtta gtatctgtgt ttccggtggg tgtaataggg gattagcccc agaagggact 1860
gagctaaaca gtgttattat gggaaaggaa atggcattgc tgctttcaac cagcgactaa 1920
tgcaatccat tcctctcttg tttatagtaa tctaagggtt gaacagttaa aacggcttca 1980
ggatagaaag ctgtttccca cctgtttgct tttaccatta aaagggaaac gtgcctctgc 2040
cccacgggta gaggggtgca cgttcctcct ggttccttcg cttgtgtttc tgtacttacc 2100
aaaaatctac catttcaata aattttgata ggagacaaaa aaaaaaaaaa aa 2152
<210> 17
<211> 2130
<212> DNA
<213> Homo sapiens
<400> 17
aaagtttggg ggccggcgga ggcggcgccg tggccgggag aaagtgtctc tcatttagga 60
gggtttgcag gtccagagta aagtcactga agagtggaag cgaggaagga acaggatgat 120
tagacctcag ctgcggaccg cggggctggg acgatgcctc ctgccggggc tgctgctgct 180
cctggtgccc gtcctctggg ccggggctga aaagctacat acccagccct cctgccccgc 240
ggtctgccag cccacgcgct gccccgcgct gcccacctgc gcgctgggga ccacgccggt 300
gttcgacctg tgccgctgtt gccgcgtctg ccccgcggcc gagcgtgaag tctgcggcgg 360
ggcgcagggc caaccgtgcg ccccggggct gcagtgcctc cagccgctgc gccccgggtt 420
ccccagcacc tgcggttgcc cgacgctggg aggggccgtg tgcggcagcg acaggcgcac 480
ctaccccagc atgtgcgcgc tccgggccga aaaccgcgcc gcgcgccgcc tgggcaaggt 540
cccggccgtg cctgtgcagt gggggaactg cggggataca gggaccagaa gcgcaggccc 600
gctcaggagg aattacaact tcatcgccgc ggtggtggag aaggtggcgc catcggtggt 660
tcacgtgcag ctgtggggca ggttacttca cggcagcagg cttgttcctg tgtacagtgg 720
ctctgggttc atagtgtctg aggacgggct cattattacc aatgcccatg ttgtcaggaa 780
ccagcagtgg attgaggtgg tgctccagaa tggggcccgt tatgaagctg ttgtcaagga 840
tattgacctt aaattggatc ttgcggtgat taagattgaa tcaaatgctg aacttcctgt 900
actgatgctg ggaagatcat ctgaccttcg ggctggagag tttgtggtgg ctttgggcag 960
cccattttct ctgcagaaca cagctactgc aggaattgtc agcaccaaac agcgaggggg 1020
caaagaactg gggatgaagg attcagatat ggactacgtc cagattgatg ccacaattaa 1080
ttatgggaat tctggtggtc ctctggtgaa cttggatggt gatgtgattg gcgtcaattc 1140
attgagggtg actgatggaa tctcctttgc aattccttca gatcgagtta ggcagttctt 1200
ggcagaatac catgagcacc agatgaaagg aaaggcgttt tcaaataaga aatatctggg 1260
tctgcaaatg ctgtccctca ctgtgcccct tagtgaagaa ttgaaaatgc attatccaga 1320
tttccctgat gtgagttctg gggtttatgt atgtaaagtg gttgaaggaa cagctgctca 1380
aagctctgga ttgagagatc acgatgtaat tgtcaacata aatgggaaac ctattactac 1440
tacaactgat gttgttaaag ctcttgacag tgattccctt tccatggctg ttcttcgggg 1500
aaaagataat ttgctcctga cagtcatacc tgaaacaatc aattaaatat cttgttttaa 1560
agtgggatta tctaaaaaaa aaaaaaccag ttatatcacg tggtttgtat tggagatgtg 1620
ccaaacatgg caagaagttt ttggatcttt ttcttacaaa gaaaaatgga tggttatcaa 1680
cccaaatgcc catcaatgac agactggata aagcaaatgt ggtacatata caccatggaa 1740
tactatgcag ccataaaaag caacagtcct ctgcagggac atggatggag ctggaaacca 1800
ttatcctcag caaactaacg caggaacaga aaaccaaata ctgcatgttc tcacttataa 1860
gtgggagctg aacaatgaga acacatgaac atagggaggg gaacaacaca cactggggcc 1920
tggcagtggg tagggtagag ggagggagag cattagcaaa aatagctaat gcatgctggg 1980
cttaacaccc aggtgatggg ttgattgata ggtgcagcaa accatcatgg cacacattta 2040
cctatgaaac aaacctgcac atcctgcata tgtacctcag aacttaaaaa taaaaataaa 2100
aagaaaaatg aaaaaaaaaa aaaaaaaaaa 2130
<210> 18
<211> 1363
<212> DNA
<213> Homo sapiens
<400> 18
atgcagctca gcctgggcta cacagccagg tgtcagatgt gtctctgctg atctgagtct 60
gcctgtggca tggacctgca tcttccctga agcatctcca gggctgaaaa atcactgacc 120
atggcaccat ggtctcatcc atctgcacag ctgcagccag tgggaggaga cgccgtgagc 180
cctgccctca tggttctgct ctgcctcggg ctgagtctgg gccccaggac ccacgtgcag 240
gcagggaacc tctccaaagc caccctctgg gctgagccag gctctgtgat cagccggggg 300
aactctgtga ccatccggtg tcaggggacc ctggaggccc aggaataccg tctggttaaa 360
gagggaagcc cagaaccctg ggacacacag aacccactgg agcccaagaa caaggccaga 420
ttctccatcc catccatgac agagcaccat gcagggagat accgctgtta ctactacagc 480
cctgcaggct ggtcagagcc cagcgacccc ctggagctgg tggtgacagg attctacaac 540
aaacccaccc tctcagccct gcccagtcct gtggtgacct caggagagaa cgtgaccctc 600
cagtgtggct cacggctgag attcgacagg ttcattctga ctgaggaagg agaccacaag 660
ctctcctgga ccttggactc acagctgacc cccagtgggc agttccaggc cctgttccct 720
gtgggccctg tgacccccag ccacaggtgg atgctcagat gctatggctc tcgcaggcat 780
atcctgcagg tatggtcaga acccagtgac ctcctggaga ttccggtctc aggagcagct 840
gataacctca gtccgtcaca aaacaagtct gactctggga ctgcctcaca ccttcaggat 900
tacgcagtag agaatctcat ccgcatgggc atggccggct tgatcctggt ggtccttggg 960
attctgatat ttcaggattg gcacagccag agaagccccc aagctgcagc tggaaggtga 1020
acagaagaga gaacaatgca ccattgaatg ctggagcctt ggaagcgaat ctgatggtcc 1080
taggaggttc gggaagacca tctgaggcct atgccatctg gactgtctgc tggcaatttc 1140
tttttttctt tcttttcttt tctttctttt tttttttttt tttttttttt gagatggagt 1200
cttgctctgt caccaggctg gaatgcagtg gcgcaatctg ggctcactgc aacctccgcc 1260
tctcgggttc aagtgattct cctgcctcag cctctggcaa tttctagagg gaggaatggg 1320
tgtttgagtg cagagacact ggtctggggt gatccatgga gga 1363
<210> 19
<211> 6348
<212> DNA
<213> Homo sapiens
<400> 19
ggcggcgcgg ggcgggcgca gcgggggtcg gggcgctggg agcccgttgg gccgcgaacg 60
cagccgccac gctggggccg ccgagatcgg gtgcccggga tgagcctcat ccggaaaaag 120
ggcttctaca agcaggacgt caacaagaca gcctgggagc tgcccaagac ctacgtgtcc 180
ccgacgcacg tcggcagcgg ggcctatggc tccgtgtgct cggccatcga caagcggtca 240
ggggagaagg tggccatcaa gaagctgagc cgaccctttc agtccgagat cttcgccaag 300
cgcgcctacc gggagctgct gctgctgaag cacatgcagc atgagaacgt cattgggctc 360
ctggatgtct tcaccccagc ctcctccctg cgcaacttct atgacttcta cctggtgatg 420
cccttcatgc agacggatct gcagaagatc atggggatgg agttcagtga ggagaagatc 480
cagtacctgg tgtatcagat gctcaaaggc cttaagtaca tccactctgc tggggtcgtg 540
cacagggacc tgaagccagg caacctggct gtgaatgagg actgtgaact gaagattctg 600
gattttgggc tggcgcgaca tgcagacgcc gagatgactg gctacgtggt gacccgctgg 660
taccgagccc ccgaggtgat cctcagctgg atgcactaca accagacagt ggacatctgg 720
tctgtgggct gtatcatggc agagatgctg acagggaaaa ctctgttcaa ggggaaagat 780
tacctggacc agctgaccca gatcctgaaa gtgaccgggg tgcctggcac ggagtttgtg 840
cagaagctga acgacaaagc ggccaaatcc tacatccagt ccctgccaca gacccccagg 900
aaggatttca ctcagctgtt cccacgggcc agcccccagg ctgcggacct gctggagaag 960
atgctggagc tagacgtgga caagcgcctg acggccgcgc aggccctcac ccatcccttc 1020
tttgaaccct tccgggaccc tgaggaagag acggaggccc agcagccgtt tgatgattcc 1080
ttagaacacg agaaactcac agtggatgaa tggaagcagc acatctacaa ggagattgtg 1140
aacttcagcc ccattgcccg gaaggactca cggcgccgga gtggcatgaa gctgtaggga 1200
ctcatcttgc atggcaccgc cggccagaca ctgcccaagg accagtattt gtcactacca 1260
aactcagccc ttcttggaat acagcctttc aagcagagga cagaagggtc cttctcctta 1320
tgtgggaaat gggcctagta gatgcagaat tcaaagatgt cggttgggag aaactagctc 1380
tgatcctaac aggccacgtt aaactgccca tctggagaat cgcctgcagg tggggccctt 1440
tccttcccgc cagagtgggg ctgagtgggc gctgagccag gccgggggcc tatggcagtg 1500
atgctgtgtt ggtttcctag ggatgctcta acgaattacc acaaacctgg tggattgaaa 1560
cagcagaact tgattccctt acagttctgg aggctggaaa tctgggatgg aggtgttggc 1620
agggctgtgg tccctttgaa ggctctgggg aagaatcctt ccttggctct ttttagcttg 1680
tggcggcagt gggcagtccg tggcattccc cagcttattg ctgcatcact ccagtctctg 1740
tctcttctgt tctctcctct tttaacaaca gtcattggat ttagggccca ccctaatcct 1800
gtgtgatctt atcttgatcc ttattaatta aacctgcaaa tactctagtt ccaaataaag 1860
tcacattctc aggttccagg tggacatgaa ttccaggggg aaatgattca actcactaca 1920
gacagctggg agggaggggc cccttcctgg gccccgtgct gaggccttgt gctctgtgaa 1980
ggaacccaat gtgtttggct gctaaattaa gggagttgca gagagagctg cagctggtgc 2040
gattgcattc aggttatttt gggtgagtga taagcaatca agatatgaaa caacagcagg 2100
ctcggagact gcgagctgca caggcagaaa tgggctcttg cctggcttga tggcaaaccg 2160
ttctgctccc tttgggagat ggcacagctc tccagagctt tgacctgaca gtggctagaa 2220
cctctctgtt tttatctgag aaactttggc agaacaaatt tccatgtgca caagctgtcg 2280
ggcacagtgg gtctcaaatt tccttgtgca ccaggggact tgttaaaatg cagattcctg 2340
ggccccaccc cagggcttgt gactcagcag gtctgcagtt gagaccttag aatgtgcatt 2400
tgaatgagga cctctcgccc tgacccaagc ctagtgattc tgatggatat cagaccatag 2460
ttcgagacat ttagtggatt tcagtcatac ttgatttgtt gggaggccta aatcaaaaac 2520
ctataggagg agactggggg gcttcagatg gagtttcaca ctcatcttac aggtgttaaa 2580
actgaggctc agaaagcttt tttttgtttg tttgtttgag acagggtctg gctctgtcac 2640
ccgggctgga gttcagtggc acaattacat cttactgcaa cctcagcctc ctgggctcaa 2700
gccatcctcc cacctcagcc tcctaagtag ctgggactac aggtctgtgc cacccaggtg 2760
caccaggact gcaggtggct aattaaaaca ttttttttct tttttgtata ggcggggttt 2820
ctctatgttg cccaggctga tcttgaactt ctggactcaa gtgatcctcc cactttggcc 2880
tcccaaagtg ctgggattat aggcatgagc caccctgcag gcccagacag catttttaag 2940
gccttgaaac tcttctgtat aatactgtaa tggtggatac ctattgtgca tttgttacca 3000
tctgtaggac tggataacac agagtgaacc ctcaagtaaa ctatggactt cagttaataa 3060
taatgtatca gtattggttc ataaattgta acaattgtgc cacactaatg caagatgtta 3120
ctcatcaaga aaactgagga gagagaaggg gaggaagtag gtgggaacct ctatactttc 3180
taccaaccta aaactgctct aaaaaataaa ccacaggccg gtcgcagtag ctcacgcctg 3240
taatcccagc accttgggag gctgaggtgg gcggatcact tgaggtcagg agttcaagac 3300
cagcctggcc aacatggtga aaccccatct ctaccaaaaa tacaaaaatt agctgggctt 3360
ggtggtgcat gcctgtaatc ccaaactact cgggaggctg aggcagaatt gcttgaacct 3420
gggaggtgga ggttgcagtg agctgagatc acaccactgc actccagcct gggtgacaga 3480
gtgagactcc atctcaaaaa aacaaaaaaa acaaataccc tgaggacaca gagacattgg 3540
gtcagacacc cacagctagg aagtggtgga gtcagattgg aacccaagta ggcttgagca 3600
ctgtacccag cttggattca agggttgccc agccttccct cttcacgcca gtctgagacc 3660
cttactgctg actgtgtcca tggtctctgt tttctctccc acagaatggc cctgctgtca 3720
aggagctggg gagtccttga ctgggactgg ctagtcttgc cacagccctg gcctcgctgg 3780
ttactaaaac tgccccaggt tccctgagtc tacatccctc taagcctcct gagaattctc 3840
actgccccaa ggaaaaagtc tagccttcct tcttggcctg gcattcaaaa ccccttgtgt 3900
tctctctaat ctcatcagct cccactgcct cccctagcta gtccttatgt cagtgtggga 3960
caccagtcct gggatccacc gtaaggttca ttctgcattc acaggttaaa ggtcttgaca 4020
agtcctgcag taaagagatc cgttcctcat ttaatccaga acttcccaga tgtacttaac 4080
cgcaggaccc attttctccc aacagcatga cacacatagc cttttttgcc cagtgcagcc 4140
cagtgcacag gtcccgatat tgcctctccc caagtaggct tggccttctt ttagtgcccg 4200
tgcgtggaag gccctccatt ctcctctcca ttctccttgg ccttcaaggc tctaccttag 4260
gcctccctcc aggcagctgt tctccatcat cccccctggg ctgcaggccc tctgtgggca 4320
gcatttagtg tgtggtttgg cctccccttc ccattgccca ctgtgagcaa atacctgtgc 4380
gtgaatgaat aatgagtgaa agatgtccca ggggcctgtc ggtcacttct ttgccccgac 4440
caggccaatg tcatatggaa ggtggcagag agcccagcag gaagcagaag tgggcggccc 4500
tgggctgtac ctttgagctg ctctcctgaa aatctctatt atttcagact cccagacccc 4560
accccccgct tcatcctctg gtgtcctcct aggccatccc cactccggaa ttaaacctca 4620
gcccctccca cagagttttc tcaaatctgt gaagtttctt caaaaggcgg tggaggtgct 4680
cagcagtgca aggtgggggg tggagggggt ggggagtaga gggagtgggg gttccacggg 4740
tttgggtctt gcccagtggg cacatggcct gtgtaatagg aaacaagtcc attctcctgc 4800
tgtggggggc agaggagctg gcggggcgag ggagggggag atgtgggctc aggtattctt 4860
ggtggatgcg cttcgttctg tggctgatgg ggtggcttaa aagatcttaa cagagagaga 4920
tcaggaagcc agactgcaag gtgggggaca tttcctaaga gcaagtgtac cctccattcc 4980
ctcttttgag gaacaaagag tatctttgct ggggcctgag tcatccatga aaacagacag 5040
cagcggtgtc ccagggcagg gcttgcctgg cgtggattgg ggtggtgctg cccccagtga 5100
ggggcagcac aaggggagac agaaatggag gaatagcccc cgtaagggca agcccagtgt 5160
gcaccagtgc ccagagctgc ctgatggagg aacagctccg taagggtgaa cccagtgtgc 5220
acgggtgccc ggagctgcct gcgtgaggct gggggctagt ttggatgagg gcatggctca 5280
actttcactt ggcacattga aatagctttt gctgtctgct agggtgtgga aaactgtttt 5340
tccatggccc caagcaatgc tatagctaca gctgaggagg gaggaatctc tccctgcctc 5400
tcctcccaac tcttggcttt tgcttcctta aatttgaaca attccctaag atctaatgct 5460
gggaggctcc ccttccttca ttacacagtg aactcatgtg ctctatctgc attcccccta 5520
aatcctcctg agcttttagg taagaggccg atgatttcac aatcggcagc agaggcctaa 5580
ggccattcca tcaaactgaa gatggcagca agttgtcctc acttcttcat tgagcaccca 5640
tgggtgtgta ctggagcaag ggtggtgcca gggattctcc tgctctggtt cctcctgcgg 5700
ggtccctgct cagctgggca gctgccctca ctctgggcgg gtggcatgtg agtgtcaaca 5760
gggcccctct cagtcagggg ctcttggcca ttttttgtgc catggatcgc ttctcaaaat 5820
catattttct tttcttttct tttgagatgg ggtctcactc cattacccag gctggagtgc 5880
agtggtgcaa tcacagctca ctgtagcctc gacctccctg ggttcaggtg atcctcccac 5940
ctcagcctcc caagtagctg ggactatagg catgcaccac catgcctggc taatttcaga 6000
ataatatttt catacacata aaatatgtag gattacaaag taagctagtt atatttatat 6060
acagttgtca aaatattttt aaaatgtata acgtgatact atgtgtatag gtttctttat 6120
taacatattg aataaaaaga tcgagggtag gcctattaaa caatggtaaa ctgaagagag 6180
atgagtgtaa acaatatttt aagatagata cctgtggcaa actgtaaagg gatatgaaaa 6240
actctgtaat ttctattggc actgctgata caactgcact ttgctacctt tgttcataac 6300
caaggaaata gaaatgactg aaaataaagt tgtattctat tccaatcc 6348
<210> 20
<211> 3760
<212> DNA
<213> Homo sapiens
<400> 20
cacccaagtc tgagttgcta aaaaatggag ctgtcactgg gccttgctct gccaggacct 60
gcagagccgg ggacctctct gtggcaagcc cagcaagatg actgctctga ggcgccctag 120
ggctgaggga ggggccgtga caccagcccc gccccccagc cacctgggaa aaggaagcac 180
aaaaaggaga agcagcaacg gctgctctgc ttccttccca tctcgctctt gggtcatgcc 240
tggccagcag aaagcagctc cataggggag gagagccacg caggatctca cagctgcagt 300
ctaatagtaa cacagaggat tcagcagtgg ccaccatggg ttctgtgaat tccagaggtc 360
acaaggcgga agcccaggtg gtgatgatgg gcctggactc ggcgggcaag accacgctcc 420
tttacaagct gaagggccac cagctggtgg agaccctgcc cactgttggt ttcaacgtgg 480
agcctctgaa agctcctggg cacgtgtcac tgactctctg ggacgttggg gggcaggccc 540
cgctcagagc cagctggaag gactatctgg aaggcacaga tatcctcgtg tacgtgctgg 600
acagcacaga tgaagcccgc ttacccgagt cggcggctga gctcacagaa gtcctgaacg 660
accccaacat ggctggcgtc cccttcttgg tgctggccaa caagcaggag gcacctgatg 720
cacttccgct gcttaagatc agaaacaggc tgagtctaga gagattccag gaccactgct 780
gggagctccg gggctgcagt gccctcactg gggaggggct gcccgaggcc ctgcagagcc 840
tgtggagcct cctgaaatct cgcagctgca tgtgtctgca ggcgagagcc catggggctg 900
agcgcggaga cagcaagaga tcttgatcca gacagagcag catatctttg ctcatacaaa 960
ctagaagaac cagctgatcc ttgagaaatt tacgcttagt ctatcaaaca agaaatgctg 1020
gcttggcccg gtggctcatg cctgtaatcc cagcactgtg ggagaccacg gtgggggaat 1080
cccttgagcc caggagttgg agagcaacat cacaacaccc catttctact aataatcaaa 1140
aaattggccg ggcatggtgg catgtgcctg tagtcccagc tacttgggag gctgaggcag 1200
gagaatcgct tgagcccaag aggtagaggt tgcagtgagc caagatcgcg ccactgcact 1260
ccagtctggg caacagagtg agaccctgtc tcaataataa taataataat aatgatgata 1320
ctctaagaaa aaaatctcaa catacttcat ttaatagctc gttaccaagt gtgaatgaag 1380
caatatgtca taatagagta gccactggtt gcataataat agagacctaa attctcaaat 1440
agggaaagag gttttaaaat caaatttgag gccaggtgca gtggctcatg ggcggaggag 1500
ggcagattac ttgaggctag gagttcaaga ccagcctggc caacatggtg aaaccccatc 1560
tctactgaaa atacaaaaat taggcatagt ggtgcacgcc tgcagtccca gctactcagg 1620
aggttgaggc agaagaatcg cttgaaccca ggaagtggag gttgcagtga gccgagattg 1680
tgctgctgca ctccagcctg ggtgaaaaag acaggctgtg tctccaaaaa gaaaaaaaaa 1740
agtcaaattc aaatatcatc tggacatgtc acaatggatc gcggatcctt atgagtgatt 1800
ttccccagtg gcccctgggg atgtgccact gtcactcaga agggcaagct aggcagggcc 1860
catacaacag caggggtctg caggttagac gttccctgcc ctgggacgct cacccctggg 1920
caagaggctg gaagttcaca ccatccaaaa tttatccttg ttttttttct gatgctaatt 1980
agcctctccc gattttatga catcttgtgt tgatcttttt caaaaactca ttttcttttt 2040
tttccttctc ttttctcctt cttgtagcac atatctttcg ttaaagatca gatcaataaa 2100
atattttatt tattcattaa tttaacaaaa aaaacagagc atttagtttg tggcaaaaac 2160
actgagcttt cgaatatgaa tcatgtgctt taggtgggaa ttgtgaattc tgaagataca 2220
gatgacagtg acgaatgcct tctgtctcat gattgacagg gaaaaggaag gttgaccata 2280
gcatcctaga aggctcatca ggtgatcatt acctagcatc catgaagcac ctgaaattat 2340
ttgcaaaatg ttacgctttg gaccattttt ccggggaagg agatccagaa ctttttacca 2400
gattttcaaa gacatctgtg actcccaaaa gttaacaatc actgatgtgg ttgttgtatc 2460
cctcatccaa ccccagaaca ctttctgtaa tctgagtttt ttaatggcaa gtggcctata 2520
tttagcacct gttctcatgt taaacagctc tgaatgttag atattctttc ttatcctgga 2580
ctggttctct ctatctctgg agtaatgcag tataaattgg ccatcagtac cctcctaaaa 2640
tctgagatct gccaggcccc tcttctaaca ccaggttagg catgcttggt tatttccagt 2700
acttgtcagt caacatgttt caagacgctg tgttagacac tagggatgca aagatgaatg 2760
agataaggcc tcaggcctca tggaaggtga gacagtaaag acattactcc cataaaaatg 2820
tgaggagaga gactcagttc agcaactgtt tattctgttt attgagcact tacttggacc 2880
aagcactgtg gtcttggtgt tttacataga ctgtctctaa ttctcacaac tctgcaaaat 2940
atatatattc ccattttata aaactacaaa ctgaggctca gagaaggtgt gacctcttgt 3000
tgcttgaggc acagagttat aaagtaacat atctggaatt tgaaatcaga tctgtttagg 3060
gctaatgctg catttttcta caacatcatg cctctagaag gtttaagcta ggtaggcttt 3120
cagccagcag acatgatggg gagagccttc taataagagg gaagagactg cttggaagca 3180
tgaagggagg tgtaagaaag ataagtaagt cagtgtactt gcaacagagg cttgggatga 3240
agggtgggtg aagttgacat cacgatagaa aacaaaactg gaatgggagt ttaggtccaa 3300
tttgggcaag gttgtttgaa tttcaataat caggggtttg ggtcaaggaa gaaaaatcat 3360
gggacttgcc atttaggagg ataattttgt ggtagtgtgg aggtgaaata aagagaaaag 3420
ggaaccttgg agctgggaag gcaggaaacc ggctagatga ccatcacaca gcaaaggagg 3480
gagtggaaga gagatgagaa aattgagagc tattattaag aaaaacagtt gagagaggaa 3540
gaatttgaag agggctcaag attttgagtc cacatgacag aaggactgga atgccatgaa 3600
ctggagaagg tgagcgctga agaaccagga tgggacgggg ctggaacagc tgggttcagc 3660
ttttgcaggg tgggtacgtg tttggttata gctgctttca gattgttcca ttatctgtac 3720
tcccaacaac cctgccggat atatttgttg gctttcactc 3760
<210> 21
<211> 2634
<212> DNA
<213> Homo sapiens
<400> 21
acgagaatag tcaggccttt ctggaagccc agtgccacag tctgcattga gcttggctca 60
ggaaagaagg gaaatccagg cggggcctgt tgggcccagg tcttgagctc ttttggctcc 120
agagttccca gcacagtcat ggatcaaaac tcagtgcctg aaaaggctca gaatgaggca 180
gacaccaata acgcagatag gttctttcgc tctcactcat cacccccaca ccacaggcca 240
ggccacagca gagctctcca ccattacgag ttgcaccatc acggcgtgcc ccaccaacgt 300
ggtgaatctc accaccctcc ggagttccaa gacttccacg accaagcctt gtcctcccat 360
gtccaccaat ctcaccacca cagcgaggca cggaatcacg gcagagccca tggccccaca 420
ggctttggtc tggctccctc tcaaggcgcc gtcccctccc accgttccta cggtgaggac 480
taccatgatg agctccaacg tgatggcagg aggcatcatg atgggtccca atacggtggg 540
ttccatcagc agagtgactc ccattaccat agggggtctc accatggcag accccaatat 600
ctcggtgaga atttatccca ctattcctct ggcgtgcccc accacggtga ggcttcccac 660
catggtgggt cctacctccc ccatggaccc aatccctaca gtgagtcctt ccaccacagc 720
gaggcttccc accttagcgg gctccaacac gatgagtccc agcatcacca agtcccccac 780
cgtggctggc cccaccatca ccaagtccac caccatggca ggtcccgtca tcatgaagcc 840
caccagcatg gaaagtctcc tcatcacgga gagaccattt cccctcattc ctctgtgggg 900
tcctaccagc gtgggatatc tgactatcac agcgagtacc accaaggtga tcaccacccc 960
agtgagtacc accatggcga ccatccccac cacacacagc accactacca ccagacccac 1020
cggcaccgag actaccatca gcaccaagac caccacggcg cgtatcattc cagttacctc 1080
catggcgact acgtccagag cacttcccaa ctctctatcc cacacacatc ccggagcctg 1140
attcacgatg cccccggccc tgctgcttct cgtacaggag tcttccccta tcacgtagca 1200
cacccacggg gctcggctca cagcatgact cggtcctcca gcacaatccg ctcacgtgtc 1260
acccagatgt ccaaaaaagt ccatacccag gatatctcca ccaaacattc agaagactgg 1320
ggcaaagaag aagggcaatt tcagaaacgc aaaaccggcc ggctccagcg gacccgcaag 1380
aagggacact ctaccaatct cttccagtgg ctgtgggaaa agctaacctt cctcattcag 1440
ggcttccggg aaatgatccg gaacctgacc caatccttgg cctttgaaac tttcatcttc 1500
ttcgttgtct gcctcaacac cgtcatgctg gtggcccaga ccttcgctga agtcgagatc 1560
cggggcgagt ggtacttcat ggccttggac tccatattct tctgcatcta cgtggtggaa 1620
gccctgctca agatcatcgc cctgggcctc tcgtacttct ttgacttctg gaacaatttg 1680
gacttcttca ttatggccat ggccgtgctg gacttcttgc tgatgcagac ccactccttc 1740
gccatctacc accaaagcct cttccggatc ctcaaggtct tcaagagcct gcgggccctg 1800
agggcaatcc gggtcctgcg gaggctcagc ttcctgacca gcgtccagga agtgacaggg 1860
accctgggcc agtccttgcc gtccatcgca gccatcctca tcctcatgtt tacctgcctc 1920
ttcctcttct ccgcggtcct ccgggcactg ttccgcaaat ctgaccccaa gcgcttccag 1980
aacatcttca ccaccatctt caccctcttc accttgctca cgctggatga ctggtccctc 2040
atctacatgg acagccgtgc ccagggcgcc tggtacatca ttcccatcct cgtaatttac 2100
atcatcatcc agtacttcat cttcctcaac ctggtgatta ctgtcctggt ggatagcttc 2160
cagacggcgc tgttcaaagg ccttgagaaa gcgaagcagg agagggccgc ccggatccaa 2220
gagaagctgc tggaagactc actgacggag ctcagagctg cagagcccaa agaggtggcg 2280
agtgaaggca ccatgctgaa gcggctcatc gagaaaaagt ttgggaccat gactgagaag 2340
cagcaggagc tcctgttcca ttacctgcag ctggtggcaa gcgtggagca ggagcagcag 2400
aagttccgct cccaggcagc cgtcatcgat gagattgtgg acaccacatt tgaggctgga 2460
gaagaggact tcaggaattg accccaggag gacaccagat acagacttca gcccctggca 2520
gtctgcccac ctgggtgcac tgggacgggt ccccagatct gctggaatga ttgtccgggc 2580
cctgcagagc aggggcccca acagagtttt taaaccccaa aaaaaaaaaa aaaa 2634
<210> 22
<211> 1548
<212> DNA
<213> Homo sapiens
<400> 22
aattgctaag ccgtgcagtc acagagggaa cacagagcct agttgtaaac ggacagagac 60
gagaggggca agggaggaca gtggatgaca gggaagacga gtgggggcag agctgctcag 120
gaccatggct gaggccatca cctatgcaga tctgaggttt gtgaaggctc ccctgaagaa 180
gagcatctcc agccggttag gacaggaccc aggggctgat gatgatgggg aaatcaccta 240
cgagaatgtt caagtgcccg cagtcctagg ggtgccctca agcttggctt cttctgtact 300
aggggacaaa gcagcggtca agtcggagca gccaactgcg tcctggagag ccgtgacgtc 360
accagctgtc gggcggattc tcccctgccg cacaacctgc ctgcgatacc tcctgctcgg 420
cctgctcctc acctgcctgc tgttaggagt gaccgccatc tgcctgggag tgcgctatct 480
gcaggtgtct cagcagctcc agcagacgaa cagggttctg gaagtcacta acagcagcct 540
gaggcagcag ctccgcctca agataacgca gctgggacag agtgcagagg atctgcaggg 600
gtccaggaga gagctggcgc agagtcagga agcactacag gtggaacaga gggctcatca 660
ggcggccgaa gggcagctac aggcctgcca ggcagacaga cagaagacga aggagacctt 720
gcaaagtgag gagcaacaga ggagggcctt ggagcagaag ctgagcaaca tggagaacag 780
actgaagccc ttcttcacat gcggctcagc agacacctgc tgtccgtcgg gatggataat 840
gcatcagaaa agctgctttt acatctcact tacttcaaaa aattggcagg agagccaaaa 900
acaatgtgaa actctgtctt ccaagctggc cacattcagt gaaatttatc cacaatcaca 960
ctcttactac ttcttaaatt cactgttgcc aaatggtggt tcagggaatt catattggac 1020
tggcctcagc tctaacaagg attggaagtt gactgatgat acacaacgca ctaggactta 1080
tgctcaaagc tcaaaatgta acaaggtaca taaaacttgg tcatggtgga cactggagtc 1140
agagtcatgt agaagttctc ttccctacat ctgtgagatg acagctttca ggtttccaga 1200
ttaggacagt cctttgcact gagttgacac tcatgccaac aagaacctgt gcccctcctt 1260
cctaacctga ggcctggggt tcctcagacc atctccttca ttctgggcag tgcccagcca 1320
ccggctgacc cacacctgac acttccagcc agtctgctgc ctgctccctc ttcctgaaac 1380
tggactgttc ctgggaaaag ggtgaagcca cctctagaag ggactttggc ctccccccaa 1440
gaacttccca tggtagaatg gggtggggga ggagggcgca cgggctgagc ggataggggc 1500
ggcccggagc cagccaggca gttttattga aatcttttta aataattg 1548
<210> 23
<211> 6705
<212> DNA
<213> Homo sapiens
<400> 23
ggaaaaggga aggaggagac tgagtgatta agtcacccac tgtgagagct ggtcttctat 60
ttaatggggg ctctctctgc ccaggagtca gaggtgcctc caggagcagc aggagcatgg 120
ccgaggatct gggactgagc tttggggaaa cagccagtgt ggaaatgctg ccagagcacg 180
gcagctgcag gcccaaggcc aggagcagca gcgcacgctg ggctctcacc tgctgcctgg 240
tgttgctccc cttccttgca ggactcacca catacctgct tgtcagccag ctccgggccc 300
agggagaggc ctgtgtgcag ttccaggctc taaaaggaca ggagtttgca ccttcacatc 360
agcaagttta tgcacctctt agagcagacg gagataagcc aagggcacac ctgacagttg 420
tgagacaaac tcccacacag cactttaaaa atcagttccc agctctgcac tgggaacatg 480
aactaggcct ggccttcacc aagaaccgaa tgaactatac caacaaattc ctgctgatcc 540
cagagtcggg agactacttc atttactccc aggtcacatt ccgtgggatg acctctgagt 600
gcagtgaaat cagacaagca ggccgaccaa acaagccaga ctccatcact gtggtcatca 660
ccaaggtaac agacagctac cctgagccaa cccagctcct catggggacc aagtctgtat 720
gcgaagtagg tagcaactgg ttccagccca tctacctcgg agccatgttc tccttgcaag 780
aaggggacaa gctaatggtg aacgtcagtg acatctcttt ggtggattac acaaaagaag 840
ataaaacctt ctttggagcc ttcttactat aggaggagag caaatatcat tatatgaaag 900
tcctctgcca ccgagttcct aattttcttt gttcaaatgt aattataacc aggggttttc 960
ttggggccgg gagtaggggg cattccacag ggacaacggt ttagctatga aatttggggc 1020
ccaaaatttc acacttcatg tgccttactg atgagagtac taactggaaa aaggctgaag 1080
agagcaaata tattattaag atgggttgga ggattggcga gtttctaaat attaagacac 1140
tgatcactaa atgaatggat gatctactcg ggtcaggatt gaaagagaaa tatttcaaca 1200
ccttcctgct atacaatggt caccagtggt ccagttattg ttcaatttga tcataaattt 1260
gcttcaattc aggagctttg aaggaagtcc aaggaaagct ctagaaaaca gtataaactt 1320
tcagaggcaa aatccttcac caatttttcc acatactttc atgccttgcc taaaaaaaat 1380
gaaaagagag ttggtatgtc tcatgaatgt tcacacagaa ggagttggtt ttcatgtcat 1440
ctacagcata tgagaaaagc tacctttctt ttgattatgt acacagatat ctaaataagg 1500
aagtatgagt ttcacatgta tatcaaaaat acaacagttg cttgtattca gtagagtttt 1560
cttgcccacc tattttgtgc tgggttctac cttaacccag aagacactat gaaaaacaag 1620
acagactcca ctcaaaattt atatgaacac cactagatac ttcctgatca aacatcagtc 1680
aacatactct aaagaataac tccaagtctt ggccaggcgc agtggctcac acctgtaatc 1740
ccaacacttt gggaggccaa ggtgggtgga tcatctaagg ccgggagttc aagaccagcc 1800
tgaccaacgt ggagaaaccc catctctact aaaaatacaa aattagccgg gcgtggtagc 1860
gcatggctgt aatcctggct actcaggagg ccgaggcaga agaattgctt gaactgggga 1920
ggcagaggtt gcggtgagcc cagatcgcgc cattgcactc cagcctgggt aacaagagca 1980
aaactctgtc caaaaaaaaa aaaataaaat aataactcca agcctttaaa aaatatcatc 2040
tgaaactgtt acatcagatt tctggcactc tactgactgt ggaagatagc cagctgactg 2100
gaagatagcc agctgattag ttccctgaag aaacctgaag acagatacct ggttaactag 2160
atcaactaca ctgccaactt gtttgatgct gagagacaat ggacttattc catgggggaa 2220
gggaaaaaag aagtcaatca ccaaatctga agaagttaac ctagatcttt gaggtttgat 2280
ttgcaacttt atatgcagag tattatgtgg gtattttccc ttaaaatatt caaagggatt 2340
tacatatggg attagctaat gagcctagcc aagaccttcc ctggaggaca ggctggtcat 2400
tgcggaggtc ccttctgtgc ttcagtgggt tcatatcctc tagtccgtat gattttccta 2460
cgctaatatg tcaagggcag gagaggcagc tctgttctcc tagcctttgt tgacttgtct 2520
gcaaagcagg aatctgccca tttgtttcca aggagcaaat gagctcatga gaatgaaaga 2580
tgttaacttc atgcattctg tgccatctga gcatttcggt attatatgac tggtgaccct 2640
tggcccgtat tataaatgct tcctatcctg ggagacctca tggatgagtc tgagaggaaa 2700
tttggcacca aaatcactct cactctggtt tccagtagac tatagaggca gagaggcatt 2760
tgagaggctc ctgagcaaag tgtccagtgt agcaggagca cttcattaat atttattgag 2820
ttataattaa ataaaaatta atttctgatt tctcagtttg gaggttaagg ctctaaatat 2880
attttctaac ctctgctagg ctaacttaag ccaggccttt ttcttgcctt ccctttctca 2940
aaacagtcag cacagactca gtgggagcac agaggagtgt ggtcacctcc acctggctca 3000
ccagagtctt catagaggaa gtgaagcctg gaagaaactg ggcgggcccc agatgaccac 3060
agggaaaggg catctcagat ggaggaatta cccttgactt aaagcagaaa agaaagattt 3120
ctcagtaact ccaaaacttg cttgatagga gaatattccc tcaaccaatt cctaggacaa 3180
tatttattgg tagatcaaga atgtttcctc aataactcta gtctagctcc atgatcagaa 3240
ctaacaccca ttaaaaacat aaaatgttct ttctgaaccg gtcttcatgg tgcgtgagag 3300
caccaagcag ctttggtatg caggaggagt tttgcacaga agagtggcct gctcaaacct 3360
gcccactgtt ctgtaggtga tctggtggat ctggaaattt atcccaagac aggaatttcc 3420
taatattcga agacatttga ggctttggga aattctctgc tgtgcattta tttggctcct 3480
gtcataagct tgttttttaa agaatgtatc atagctcaag tttttactgc tgattttgtt 3540
aaattctgta tagtatattt tttacggaaa ggcacagtca gacattccta atagggctca 3600
tgtcagaact tctgttccca aggcattatc tccatagcaa aaattagtgc actgttttca 3660
aaagtgaggt gggaaaatgc ttttaagatc atgtgatgtt cccctaaaag gggttaatgg 3720
ggtgtattca gggtttggga gggaggaaga agcatgcttt agaaaacagt aaatttaggg 3780
agaaaatgct ttgttggtta aatgtcactc aaaaggctga attcaaatca attccacaaa 3840
catttactga gtacctactg cccctgggga cacagagata aattatttag tctcagacac 3900
actcattcta acttcccagc acctctactg tctgcagatt ctttaattta ttttggttgt 3960
attagctaat taattcgtaa actttaggca catggatcta ttctcattat gaaaatggat 4020
gccatttgat taaggctgat gactaacaaa atgatttgtg tttactcgaa gtgttttttt 4080
aaaaatagct actcaaggat agttttccat aaatcaagaa ggtaaaaaag ttcccatttt 4140
ttattgtaga atccattatt taaactacat gtagagacag gttattattt gctatattca 4200
agtttggtca tcaataccct taaaaatatt agaattttat ggatgaccca gaaatgcttt 4260
gaaaatctgt gttcctcagc aaatacagag accatgatca aaatgcacag aatcactaac 4320
attttgatgc tagcatggtt tcagtctatt tggcagaaca gaattgatta tgctactaaa 4380
atttcttttt cttttttttt tttttttttt ttgagacaga gtcttgcttt gtcacccagg 4440
ctgaagtgca gtggcaggat ctcagttcac tgcaacctct gcctcccagg ttcacgccat 4500
tctcctgctt cagcctcccg agtagctggg actacaggct cccaccacca tgcccggcta 4560
attttttgca tttttagtag agacggggtt tcaccgtgtt agccaggatg gtctcgatct 4620
cctgacctcg tgatccgccc gcctcagcct tccaaagtgc tgggattaca ggcgtgagcc 4680
actgtgcccg gactctgatt ttttttttac taaggtacag taagaaaagg gaaaagtgta 4740
cgttttcact tcctgaaata tgtcaggttg aatcaataat agagcacacc agaactcttg 4800
gctccatttc aacctaaact attcagttct catcacccca gaggaaattc cgcctctgtg 4860
ctggtcagta atccccctgg attataaaag tttaactaac tcactgtgca caaggcacgg 4920
ccattgccaa cattctcttg caaggtattt tcccaagccc ttacccaatt ctgtttccat 4980
gattgtgaca ttggggatta attctgcaag acagaactgt ttatattctg taccttaaaa 5040
acacatgcaa acatctcttg ccttaagatt tctggctttc ctatggccca gagtcctaga 5100
agtgttttga tatttgtagc agaattttca agtgtacatc cttatcctgg atattaacat 5160
ttttgcatca tattggcagc tggacctaca gagaatttag tagactgtta acctaataag 5220
ccttgaatcc ttttgcacca gtggtgagag aatgtggatc agagccatca cctccatgcc 5280
ccgtcaccct ctaacaacca catttacaac ttccccagct ctgagacaca cttgcctcca 5340
ccccttccat caccccattt taagatgaaa ataccacacc agcctggaag gaagaagtta 5400
cttgcccagg gccacatagt gagttaaggg ctgatctaga gctaggaagc tgtcttcctg 5460
aaccataatc ctggactctt ctaacctctc tactcatcgc aaatagagtt cattttagtg 5520
atttgaagga agatgggaca agtattttca aacacctgta ggacaacatg gaagtgggag 5580
gagacttcta ctgtagctcc ccagagaaga gagctagggc tacagagttg cagttacaag 5640
gttgccctct ctggcttgat ccccaaagga attttctact ccaaaataga atttttctag 5700
gatgctattt ctcagtccct ggagatactc aaacaaaggg cttgtcacaa gggtttttgt 5760
agaagctatt cttcacagag gttgggggag agattaagcc aaaggatctc tgaggtcttt 5820
ttcaaatcta taattatgtg gccttttgtt cattgacttc catgtgttct agttgatcat 5880
tacaaacctg gcaggccttc tcaagggttc agtaattagc tgtcatttcc catttgtcca 5940
gagagtgtcc aacacaaaat acccctaaga tcttggccaa tagagaaatg tcatggaatt 6000
ttagaaatga cagtatctgc ggagtttatt ccaagttata tcatttcaaa gatgaagaaa 6060
cccaggctca gagggagcca tcacatccac accctgtcac ccttcgtggc cagtgccaga 6120
cagtagctag ttggatgcta aaagtagaat ttagatatct taacaataag cccagcagtc 6180
tttcaacttc attcgtaaat catttttgtt ttgagcatct gtcacgtggc agcacttgcc 6240
tggatactgg agagctgaga aggaatgcga caggcaagtc ctactctcac agtgtataca 6300
ttcaggagga acaagacaca cagtgccaag taaataaagt agctgaactt catcaaatga 6360
ttttattctt aaagtcatta aagcatgtaa tgttcccctt tttttgtttc aggggtgtac 6420
agattgaaga agtgtaggtg tttatgtggt tttagtgaca aaccccatgt gctttcattg 6480
attttatgtt ttatgttaaa acatcaaccg caaggtaaaa tgcatattgt atgttgttgg 6540
atacgtactt aactggtatg catcccatgt ctttgggtac tagtgtatga attctaatct 6600
ctgtaaatga aatgttgtat gtgttaatat atttaataga tgtaacttaa taaactggca 6660
ttgaagactg aagaattttc acactgtcaa aaaaaaaaaa aaaaa 6705
<210> 24
<211> 3740
<212> DNA
<213> Homo sapiens
<400> 24
gggacggcgg cggcgcagct cggaacccgc cagggtccag ggtccaggtt ccagcgcccg 60
gcggcccagg caccccccga gcccagctcc acacaccgtt cctggatctc ctctccccag 120
gcggagcgtg cccctgccca gtccagtgac cttcgcctgt tggagccctg gttaattttt 180
gcccagtctg cctgttgtgg ggctcctccc ctttggggat ataagcccgg cctggggctg 240
ctccgttctc tgcctggcct gaggctccct gagccgcctc cccaccatca ccatggccaa 300
gggcttctat atttccaagt ccctgggcat cctggggatc ctcctgggcg tggcagccgt 360
gtgcacaatc atcgcactgt cagtggtgta ctcccaggag aagaacaaga acgccaacag 420
ctcccccgtg gcctccacca ccccgtccgc ctcagccacc accaaccccg cctcggccac 480
caccttggac caaagtaaag cgtggaatcg ttaccgcctc cccaacacgc tgaaacccga 540
ttcctaccgg gtgacgctga gaccgtacct cacccccaat gacaggggcc tgtacgtttt 600
taagggctcc agcaccgtcc gtttcacctg caaggaggcc actgacgtca tcatcatcca 660
cagcaagaag ctcaactaca ccctcagcca ggggcacagg gtggtcctgc gtggtgtggg 720
aggctcccag ccccccgaca ttgacaagac tgagctggtg gagcccaccg agtacctggt 780
ggtgcacctc aagggctccc tggtgaagga cagccagtat gagatggaca gcgagttcga 840
gggggagttg gcagatgacc tggcgggctt ctaccgcagc gagtacatgg agggcaatgt 900
cagaaaggtg gtggccacta cacagatgca ggctgcagat gcccggaagt ccttcccatg 960
cttcgatgag ccggccatga aggccgagtt caacatcacg cttatccacc ccaaggacct 1020
gacagccctg tccaacatgc ttcccaaagg tcccagcacc ccacttccag aagaccccaa 1080
ctggaatgtc actgagttcc acaccacgcc caagatgtcc acgtacttgc tggccttcat 1140
tgtcagtgag ttcgactacg tggagaagca ggcatccaat ggtgtcttga tccggatctg 1200
ggcccggccc agtgccattg cggcgggcca cggcgattat gccctgaacg tgacgggccc 1260
catccttaac ttctttgctg gtcattatga cacaccctac ccactcccaa aatcagacca 1320
gattggcctg ccagacttca acgccggcgc catggagaac tggggactgg tgacctaccg 1380
ggagaactcc ctgctgttcg accccctgtc ctcctccagc agcaacaagg agcgggtggt 1440
cactgtgatt gctcatgagc tggcccacca gtggttcggg aacctggtga ccatagagtg 1500
gtggaatgac ctgtggctga acgagggctt cgcctcctac gtggagtacc tgggtgctga 1560
ctatgcggag cccacctgga acttgaaaga cctcatggtg ctgaatgatg tgtaccgcgt 1620
gatggcagtg gatgcactgg cctcctccca cccgctgtcc acacccgcct cggagatcaa 1680
cacgccggcc cagatcagtg agctgtttga cgccatctcc tacagcaagg gcgcctcagt 1740
cctcaggatg ctctccagct tcctgtccga ggacgtattc aagcagggcc tggcgtccta 1800
cctccacacc tttgcctacc agaacaccat ctacctgaac ctgtgggacc acctgcagga 1860
ggctgtgaac aaccggtcca tccaactccc caccaccgtg cgggacatca tgaaccgctg 1920
gaccctgcag atgggcttcc cggtcatcac ggtggatacc agcacgggga ccctttccca 1980
ggagcacttc ctccttgacc ccgattccaa tgttacccgc ccctcagaat tcaactacgt 2040
gtggattgtg cccatcacat ccatcagaga tggcagacag cagcaggact actggctgat 2100
agatgtaaga gcccagaacg atctcttcag cacatcaggc aatgagtggg tcctgctgaa 2160
cctcaatgtg acgggctatt accgggtgaa ctacgacgaa gagaactgga ggaagattca 2220
gactcagctg cagagagacc actcggccat ccctgtcatc aatcgggcac agatcattaa 2280
tgacgccttc aacctggcca gtgcccataa ggtccctgtc actctggcgc tgaacaacac 2340
cctcttcctg attgaagaga gacagtacat gccctgggag gccgccctga gcagcctgag 2400
ctacttcaag ctcatgtttg accgctccga ggtctatggc cccatgaaga actacctgaa 2460
gaagcaggtc acacccctct tcattcactt cagaaataat accaacaact ggagggagat 2520
cccagaaaac ctgatggacc agtacagcga ggttaatgcc atcagcaccg cctgctccaa 2580
cggagttcca gagtgtgagg agatggtctc tggccttttc aagcagtgga tggagaaccc 2640
caataataac ccgatccacc ccaacctgcg gtccaccgtc tactgcaacg ctatcgccca 2700
gggcggggag gaggagtggg acttcgcctg ggagcagttc cgaaatgcca cactggtcaa 2760
tgaggctgac aagctccggg cagccctggc ctgcagcaaa gagttgtgga tcctgaacag 2820
gtacctgagc tacaccctga acccggactt aatccggaag caggacgcca cctctaccat 2880
catcagcatt accaacaacg tcattgggca aggtctggtc tgggactttg tccagagcaa 2940
ctggaagaag ctttttaacg attatggtgg tggctcgttc tccttctcca acctcatcca 3000
ggcagtgaca cgacgattct ccaccgagta tgagctgcag cagctggagc agttcaagaa 3060
ggacaacgag gaaacaggct tcggctcagg cacccgggcc ctggagcaag ccctggagaa 3120
gacgaaagcc aacatcaagt gggtgaagga gaacaaggag gtggtgctcc agtggttcac 3180
agaaaacagc aaatagtccc cagcccttga agtcacccgg cccccatgca aggtgcccac 3240
atgtgtccat cccagcggct ggtgcagggc ctccattcct ggagcccgag gcaccagtgt 3300
cctcccctca aggacaaagt ctccagccca cgttctctct gcctgtgagc cagtctagtt 3360
cctgatgacc caggctgcct gagcacctcc cagcccctgc ccctcatgcc aaccccgccc 3420
taggcctggc atggcacctg tcgcccagtg ccctggggct gatctcaggg aagcccagct 3480
ccagggccag atgagcagaa gctctcgatg gacaatgaac ggccttgctg ggggccgccc 3540
tgtaccctct ttcacctttc cctaaagacc ctaaatctga ggaatcaaca gggcagcaga 3600
tctgtatatt tttttctaag agaaaatgta aataaaggat ttctagatga aaaaaaaaaa 3660
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 3720
aaaaaaaaaa aaaaaaaaaa 3740
<210> 25
<211> 1326
<212> DNA
<213> Homo sapiens
<400> 25
tggacaaatt tgcgggctgg ggaccatgga agtggaggaa atctacaagc accaggaagt 60
caagatgcaa gcaccagcct tcagggacaa gaaacagggg gtctcagcca agaatcaagg 120
tgcccatgac ccagactatg agaatatcac cttggccttc aaaaatcagg accatgcaaa 180
gggtggtcat tcacgaccca cgagccaagt cccagcccag tgcaggccgc cctcagactc 240
cacccaggtc ccctgctggt tgtacagagc catcctgagc ctgtacatcc tcctggccct 300
ggcctttgtc ctctgcatca tcctgtcagc cttcatcatg gtgaagaatg ctgagatgtc 360
caaggagctg ctgggcttta aaagggagct ttggaatgtc tcaaactccg tacaagcatg 420
cgaagagaga cagaagagag gctgggattc cgttcagcag agcatcacca tggtcaggag 480
caagattgat agattagaga cgacattagc aggcataaaa aacattgaca caaaggtaca 540
gaaaatcttg gaggtgctgc agaaaatgcc acagtcctca cctcaataaa tgagaggaca 600
ttgtggcagc caaagccaca acttggaaga tggggctgca cctgccaacg aagacgggaa 660
atgacccccc ccccccagcc tagtgtgaac ctgcccctcg tcccacgtat agaaaaacct 720
cgagtcatgg tgaatgagtg tctcggagtt gctcgtgtgt gtgtacacct gcgtgcgtgt 780
gtgtgcgtgt gtgcgcgtgt gttcgtgtat gtgcgtgtgt gcgtgcgcgt gtgtgtgcat 840
tttgcaaagg gtggacattt cagtgtatct cccagaaagg tgatgaatga ataggactga 900
gagtcacagt gaatgtggca tgcatgcctg tgtcatgtga catatgtgag tctcggcatg 960
tcacggtggg tggctgtgtc tgagcacctc cagcagatgt cactctgagt gtgggtgttg 1020
gtgacatgca ttgcacgggc ctgtctccct gtttgtgtaa acatactaga gtatactgcg 1080
gcgtgttttc tgtctaccca tgtcatggtg ggggagattt atctccgtac atgtgggtgt 1140
cgccatgtgt gccctgtcac tatctgtggc tgggtgaacg gctgtgtcat tatgagtgtg 1200
ccgagttatg ccaccctgtg tgctcagggc acatgcacac agacatttat ctctgcactc 1260
acattttgtg acttatgaag ataaataaag tcaagggaaa acagcgtcaa aaaaaaaaaa 1320
aaaaaa 1326
<210> 26
<211> 1205
<212> DNA
<213> Homo sapiens
<400> 26
acagaaggag gaaggtcagc agccccgaca gccgacagtc acagcagctc tgacaagagc 60
gttcctggag cccagctcct ctccacagag gacaagcagg cagcagagac catgggcccc 120
ccctcagccg ctccccgtgg agggcacagg ccctggcagg ggctcctgat cacagcctca 180
cttttaacct tctggcaccc gcccaccact gtccagttca ctattgaagc cctgccgtcc 240
agtgctgcag agggaaagga tgttcttcta ctggcctgca atatttcaga aactattcaa 300
gcctattatt ggcacaaggg gaaaacggca gaagggagcc ctctcattgc tggttatata 360
acagacattc aagcaaatat cccaggggcc gcatacagtg gtcgagagac agtatacccc 420
aatggatccc tgctgttcca aaacatcacc ctggaggacg caggatccta caccctacga 480
accataaatg ccagttacga ctctgaccaa gcaactggcc agctccacgt acaccaaaac 540
aacgtcccag gccttcctgt gggggccgtc gctggcatcg tgactggggt cctggttggg 600
gtggctctgg tggccgccct ggtgtgtttt ctgcttctct ccaggactgg aagggccagc 660
atccagcgtg acctcaggga gcagccgccc ccagcctcca cccctggcca tggtccctct 720
cacagatcca ccttctcggc ccctctaccc agccccagaa cagccactcc catctatgag 780
gaattgctat actctgatgc aaacatttac tgccagatcg accacaaagc agatgtggtc 840
tcttaggttc ctctgggagc tgctcttgtg ggttgatgga gcgtccccga agctcccagc 900
cctggggacg gggaaggaca tggagcctga gccagagaac cagctctgag tcctgaggag 960
acacaggcct ggggacaggg agggatggga gtccctgctg aatatctgga gaccctgaca 1020
ggttgccctg ggctctgggt gggccgggac aaaggcctct catcaccaca ggaagcgggg 1080
gcttgcaagg aaagtgaatg ggcctgtggc ccacccgggg tcaccaggaa aggatctgaa 1140
taaagaggac ccttcctctc attggctctt tttctgctca cgggaactta gcagaaactc 1200
acctg 1205
<210> 27
<211> 1781
<212> DNA
<213> Homo sapiens
<400> 27
atctctgtgc cctccccctt gcaggggaaa cagcacacac tagtgaaatc ttgtcttagt 60
gtgtccggaa ttggtgggtt cttggtctca ctgagttcta gaatgaagct gcagaccctc 120
gcagtgagtg ttacagctct taaggctctc tgactgccac ccctgcctgc ctgcccggcc 180
ctgcacaaca tgcagccctc cggcctcgag ggtcccggca cgtttggtcg gtggcctctg 240
ctgagtctgc tgctcctgct gctgctgctc cagcctgtaa cctgtgccta caccacgcca 300
ggccccccca gagccctcac cacgctgggc gcccccagag cccacaccat gccgggcacc 360
tacgctccct cgaccacact cagtagtccc agcacccagg gcctgcaaga gcaggcacgg 420
gccctgatgc gggacttccc gctcgtggac ggccacaacg acctgcccct ggtcctaagg 480
caggtttacc agaaagggct acaggatgtt aacctgcgca atttcagcta cggccagacc 540
agcctggaca ggcttagaga tggcctcgtg ggcgcccagt tctggtcagc ctatgtgcca 600
tgccagaccc aggaccggga tgccctgcgc ctcaccctgg agcagattga cctcatacgc 660
cgcatgtgtg cctcctattc tgagctggag cttgtgacct cggctaaagc tctgaacgac 720
actcagaaat tggcctgcct catcggtgta gagggtggcc actcgctgga caatagcctc 780
tccatcttac gtaccttcta catgctggga gtgcgctacc tgacgctcac ccacacctgc 840
aacacaccct gggcagagag ctccgctaag ggcgtccact ccttctacaa caacatcagc 900
gggctgactg actttggtga gaaggtggtg gcagaaatga accgcctggg catgatggta 960
gacttatccc atgtctcaga tgctgtggca cggcgggccc tggaagtgtc acaggcacct 1020
gtgatcttct cccactcggc tgcccggggt gtgtgcaaca gtgctcggaa tgttcctgat 1080
gacatcctgc agcttctgaa gaagaacggt ggcgtcgtga tggtgtcttt gtccatggga 1140
gtaatacagt gcaacccatc agccaatgtg tccactgtgg cagatcactt cgaccacatc 1200
aaggctgtca ttggatccaa gttcatcggg attggtggag attatgatgg ggccggcaaa 1260
ttccctcagg ggctggaaga cgtgtccaca tacccggtcc tgatagagga gttgctgagt 1320
cgtggctgga gtgaggaaga gcttcagggt gtccttcgtg gaaacctgct gcgggtcttc 1380
agacaagtgg aaaaggtaca ggaagaaaac aaatggcaaa gccccttgga ggacaagttc 1440
ccggatgagc agctgagcag ttcctgccac tccgacctct cacgtctgcg tcagagacag 1500
agtctgactt caggccagga actcactgag attcccatac actggacagc caagttacca 1560
gccaagtggt cagtctcaga gtcctccccc cacatggccc cagtccttgc agttgtggcc 1620
accttcccag tccttattct gtggctctga tgacccagtt agtcctgcca gatgtcactg 1680
tagcaagcca cagacacccc acaaagttcc cctgttgtgc aggcacaaat atttcctgaa 1740
ataaatgttt tggacataga aacagaaaaa aaaaaaaaaa a 1781
<210> 28
<211> 1629
<212> DNA
<213> Homo sapiens
<400> 28
acacatcagg ggcttgctct tgcaaaacca aaccacaaga cagacttgca aaagaaggca 60
tgcacagctc agcactgctc tgttgcctgg tcctcctgac tggggtgagg gccagcccag 120
gccagggcac ccagtctgag aacagctgca cccacttccc aggcaacctg cctaacatgc 180
ttcgagatct ccgagatgcc ttcagcagag tgaagacttt ctttcaaatg aaggatcagc 240
tggacaactt gttgttaaag gagtccttgc tggaggactt taagggttac ctgggttgcc 300
aagccttgtc tgagatgatc cagttttacc tggaggaggt gatgccccaa gctgagaacc 360
aagacccaga catcaaggcg catgtgaact ccctggggga gaacctgaag accctcaggc 420
tgaggctacg gcgctgtcat cgatttcttc cctgtgaaaa caagagcaag gccgtggagc 480
aggtgaagaa tgcctttaat aagctccaag agaaaggcat ctacaaagcc atgagtgagt 540
ttgacatctt catcaactac atagaagcct acatgacaat gaagatacga aactgagaca 600
tcagggtggc gactctatag actctaggac ataaattaga ggtctccaaa atcggatctg 660
gggctctggg atagctgacc cagccccttg agaaacctta ttgtacctct cttatagaat 720
atttattacc tctgatacct caacccccat ttctatttat ttactgagct tctctgtgaa 780
cgatttagaa agaagcccaa tattataatt tttttcaata tttattattt tcacctgttt 840
ttaagctgtt tccatagggt gacacactat ggtatttgag tgttttaaga taaattataa 900
gttacataag ggaggaaaaa aaatgttctt tggggagcca acagaagctt ccattccaag 960
cctgaccacg ctttctagct gttgagctgt tttccctgac ctccctctaa tttatcttgt 1020
ctctgggctt ggggcttcct aactgctaca aatactctta ggaagagaaa ccagggagcc 1080
cctttgatga ttaattcacc ttccagtgtc tcggagggat tcccctaacc tcattcccca 1140
accacttcat tcttgaaagc tgtggccagc ttgttattta taacaaccta aatttggttc 1200
taggccgggc gcggtggctc acgcctgtaa tcccagcact ttgggaggct gaggcgggtg 1260
gatcacttga ggtcaggagt tcctaaccag cctggtcaac atggtgaaac cccgtctcta 1320
ctaaaaatac aaaaattagc cgggcatggt ggcgcgcacc tgtaatccca gctacttggg 1380
aggctgaggc aagagaattg cttgaaccca ggagatggaa gttgcagtga gctgatatca 1440
tgcccctgta ctccagcctg ggtgacagag caagactctg tctcaaaaaa taaaaataaa 1500
aataaatttg gttctaatag aactcagttt taactagaat ttattcaatt cctctgggaa 1560
tgttacattg tttgtctgtc ttcatagcag attttaattt tgaataaata aatgtatctt 1620
attcacatc 1629
<210> 29
<211> 941
<212> DNA
<213> Homo sapiens
<400> 29
cgcctccctc gctccacgcg cgcccggact cggcggccag gcttgcgcgc ggttcccctc 60
ccggtgggcg gattcctggg caagatgaag tgggtgtggg cgctcttgct gttggcggcg 120
ctgggcagcg gccgcgcgga gcgcgactgc cgagtgagca gcttccgagt caaggagaac 180
ttcgacaagg ctcgcttctc tgggacctgg tacgccatgg ccaagaagga ccccgagggc 240
ctctttctgc aggacaacat cgtcgcggag ttctccgtgg acgagaccgg ccagatgagc 300
gccacagcca agggccgagt ccgtcttttg aataactggg acgtgtgcgc agacatggtg 360
ggcaccttca cagacaccga ggaccctgcc aagttcaaga tgaagtactg gggcgtagcc 420
tcctttctcc agaaaggaaa tgatgaccac tggatcgtcg acacagacta cgacacgtat 480
gccgtgcagt actcctgccg cctcctgaac ctcgatggca cctgtgctga cagctactcc 540
ttcgtgtttt cccgggaccc caacggcctg cccccagaag cgcagaagat tgtaaggcag 600
cggcaggagg agctgtgcct ggccaggcag tacaggctga tcgtccacaa cggttactgc 660
gatggcagat cagaaagaaa ccttttgtag caatatcaag aatctagttt catctgagaa 720
cttctgatta gctctcagtc ttcagctcta tttatcttag gagtttaatt tgcccttctc 780
tccccatctt ccctcagttc ccataaaacc ttcattacac ataaagatac acgtgggggt 840
cagtgaatct gcttgccttt cctgaaagtt tctggggctt aagattccag actctgattc 900
attaaactat agtcacccgt gtcctgtgaa aaaaaaaaaa a 941
<210> 30
<211> 4196
<212> DNA
<213> Homo sapiens
<400> 30
agtggcgggg aagcaaagca caggagcgct gtggtgccag cggccgggct agggacgact 60
ggcgggtttg cgctggaccc gaccccgagg gcgggcgcaa gggggcgggc gctgccgtac 120
tcaggccgcg gggccagggc gggccggccg gcggggcatt taaaccccgc tgacagccag 180
tccagcccgg gacacgcgcc cagctctgta gcctcctccg tcgactcagc cttaggtacc 240
ggtcaggcaa aatgcggtcc tccctggctc cgggagtctg gttcttccgg gccttctcca 300
gggacagctg gttccgaggc ctcatcctgc tgctgacctt cctaatttac gcctgctatc 360
acatgtccag gaagcctatc agtatcgtca agagccgtct gcaccagaac tgctcggagc 420
agatcaaacc catcaatgat actcacagtc tcaatgacac catgtggtgc agctgggccc 480
catttgacaa ggacaactat aaggagttac tagggggcgt ggacaacgcc ttcctcatcg 540
cctatgccat cggcatgttc atcagtgggg tttttgggga gcggcttccg ctccgttact 600
acctctcagc tggaatgctg ctcagtggcc ttttcacctc gctctttggc ctgggatatt 660
tctggaacat ccacgagctc tggtactttg tggtcatcca ggtctgtaat ggactcgtcc 720
agaccacagg ctggccctct gtggtgacct gtgttggcaa ctggttcggg aaggggaagc 780
gggggttcat catgggcatc tggaattccc acacatctgt gggcaacatc ctgggctccc 840
tgatcgccgg catctgggtg aacgggcagt ggggcctgtc gttcatcgtg cctggcatca 900
ttactgccgt catgggcgtc atcaccttcc tcttcctcat cgaacaccca gaagatgtgg 960
actgcgcccc tcctcagcac cacggtgagc cagctgagaa ccaggacaac cctgaggacc 1020
ctgggaacag tccctgctct atcagggaga gcggccttga gactgtggcc aaatgctcca 1080
aggggccatg cgaagagcct gctgccatca gcttctttgg ggcgctccgg atcccaggcg 1140
tggtcgagtt ctctctgtgt ctgctgtttg ccaagctggt cagttacacc ttcctctact 1200
ggctgcccct ctacatcgcc aatgtggctc actttagtgc caaggaggct ggggacctgt 1260
ctacactctt cgatgttggt ggcatcatag gcggcatcgt ggcagggctc gtctctgact 1320
acaccaatgg cagggccacc acttgctgtg tcatgctcat cttggctgcc cccatgatgt 1380
tcctgtacaa ctacattggc caggacggga ttgccagctc catagtgatg ctgatcatct 1440
gtgggggcct ggtcaatggc ccatacgcgc tcatcaccac tgctgtctct gctgatctgg 1500
ggactcacaa gagcctgaag ggcaacgcca aagccctgtc cacggtcacg gccatcattg 1560
acggcaccgg ctccataggt gcggctctgg ggcctctgct ggctgggctc atctccccca 1620
cgggctggaa caatgtcttc tacatgctca tctctgccga cgtcctagcc tgcttgctcc 1680
tttgccggtt agtatacaaa gagatcttgg cctggaaggt gtccctgagc agaggcagcg 1740
gctctagtat ggtcctaacc caccagtgat agtattttcc tcaagtccca tgacttttgt 1800
ataaagaaat atgaggcccc aattggaaca gcagcatgga gggtcccagt tgggtcccca 1860
acgtgctccc catgggcaag acaatggaaa cttccacaag cagggaaggc aaaccctctt 1920
tattgaacat tagccagccc agcccagacc ccagggctgc ctaaggacac agagattctc 1980
catgggaagg ggactgccaa gcatgaggaa atagaagatt caggggcctg agctctggaa 2040
gctgcaagca aaagggatgg gactagggct gagttgtgtc tccattttga taaggaaagg 2100
atatgctcag actcttgctt gttcagattc caagacagaa ggcttcacaa ggccaacgcc 2160
tggaaaatgg gcatctctcc ttcccatgtt aagctttaac ctctgtaatc tgcctgtatc 2220
tataggtggg catctcactc caccaaagga gcccagcctc tctttgtccc tctatccatg 2280
caacagtctt ctctgtgcat ttccccaagc tgggccctct tctactctcc atttaggcct 2340
gttgataact ccattacccg cccatcactg ctgttcctcc agggccagca ctcgggcgag 2400
gcaggggagc tgccttcggt acataatttg aaggggcact ccctcttggg cacatgccgg 2460
ccctgagtgc ctcccttgcc tcactctgat cctggcccca taatgtcctc agtggaaggt 2520
gatgggggcc ggtgctgtgg ggagagtaga aagaggggtt ggcatgacta aaaataccag 2580
tatgtgtatt aagtattttg agaatgaaat gccaaggagt gcctactata tgccagctct 2640
aggaatggag tagacagtgg acacaagaag gacttacgcc ctgagcacag gtgccaatgg 2700
tgacaagact ggcaagacgt gagggcatga atggttcatt caggcagctg ctgcagatgt 2760
ggtcacctgg tgccatctgc tgctcccttt tccacttttc tatgtcctcc ttccacccca 2820
agtcccggat cactcgctgt tttctggcta gctcttggca tctccatctg agcctaaagt 2880
tgcccactgg caccaataga ttctgtttga cctgctgtgc ccatgctcat ctttgtcggg 2940
gcttggcttg gcagcgagcg aggctggcat ggggtgctga agtggggtct cagtgagggg 3000
tgacagcgtg ctggcagtcc tcacagccct cgctcgctct cggcgcctcc tctgcctggg 3060
ctcccacttt ggcggcactt gaggagccct tcagcccacc gctgcactgt ggggagcccc 3120
tttctgggct ggccaaggcc agagcaggct ccctcagctt gcagggaggt gtggagcgag 3180
aggcgcgagc gggaaccggg gctgcatgca gcgcttgcgg gccagctgga gttccgggtg 3240
ggcatgggct tggcgggcct gcactcggag cagccggccg gcccttccgg ccccgggcag 3300
tgagggactt ggcacccggg ccagcggctg cagagggtgt actgggtccc ccagcagtgc 3360
cggcccacct gcgctgtgct tgatttctcg ctgggcctta gctgccttcc cgcggggcag 3420
ggctcgggac ctgcagcccg cggtgcctga gcctcccacc cgctccatgg gctcctgtgg 3480
ggcccgagcc tccccgacga gtaccacccc ctgctccagg gcgcccagtc ccatcgacca 3540
cccaagggct gaggagtgcg agcgcacggc gcgggactgg caggcagctc cacctgcagc 3600
cccggtgcgg gatccactag gtgaagccag ctgggctcct gagtctgatg gggacgtgga 3660
gagtccttat gtcctgctca gggattgtaa acacaccaat cagcaccctg tgtttagctc 3720
aaggtttgtg agtgcaccag tcgacactct gtatctagct gctctggtgg ggcctcggag 3780
aacctttata tctagctcag ggattgtaaa tacacccatc ggcactgtgt atctagctca 3840
aggtttataa acacaccaat caacaccctg tgtctagctc agggtttgtg agtgcaccaa 3900
tcaacactct gtatctagct gctctggtgg ggccttggag aacctgtgtg tcgaaactct 3960
gtatctaact aatctgatgg ggacgtggag aacctttgta tctagctcag ggattgtaaa 4020
cgcaccaatc aacgacctgt caaaacaggc cactcggctc taccaataag caggatgtgg 4080
gtggggccag ataagagaat aaaagcaggc tgcccgagcc agcattggca actcgctcgg 4140
gtccccttcc acgctgtggg agctttgttc tttgcaataa atcttgctac tgctca 4196
<210> 31
<211> 2518
<212> DNA
<213> Homo sapiens
<400> 31
ctcgggaggt cactcggctg ctgggcgggc tgctgtcaca ggcgctgcgt gccctggctc 60
tgctcgccac tggccggcgc gctcccggcg cacggagcac actcgcgctc ccggcgcacg 120
gagcacactc gcgctccggg actgaaacct gagcagccgt agcagccgaa tttgggagca 180
tatccttgtc actgcagcca gaaagccctt cgatccccat cagagaggtc acatgagccc 240
cgaggtcacc tgcccgcgga ggggccacct gcctcgcttc cacccgagga cctgggttga 300
gcccgtggtg gcctcgtccc aggtggctgc ctccctctac gatgcggggc tactcctcgt 360
ggtgaaggcg tcctacggaa ccggaggctc ctccaaccac agtgccagcc catcgccccg 420
gggggctcta gaggaccaac agcagagagc catctccaat ttctacatta tctacaacct 480
tgtggtgggc ctgtcccccc tgctgtccgc ctacgggctg ggatggctca gcgaccgcta 540
ccaccgaaag atctccatct gcatgtcgct gctgggcttc ctgctctccc gcctcgggct 600
gctgctcaag gtgctgctgg actggccagt ggaggtgctg tacggggcgg cggcgctgaa 660
cgggctattc ggcggcttct ccgccttctg gtccggggtc atggcgctgg gatcgctggg 720
ctcctccgag ggccgccgct ctgtgcgcct catcctcatt gacctgatgc tgggcttggc 780
ggggttctgc gggagcatgg cttccgggca tctcttcaag cagatggctg ggcactctgg 840
gcagggcctg atactgacgg cctgcagcgt gagctgtgcc tcgtttgccc tgctctacag 900
ccttttggtg ctaaaggtcc ctgagtcggt ggccaaaccc agccaggagc tccccgccgt 960
ggataccgtg tctggcacgg ttggcacata ccgcactctg gatcctgatc agttggacca 1020
acagtatgca gtggggcacc ctccatctcc tggaaaagca aaaccccata aaaccaccat 1080
tgccttgctc tttgtgggtg ctatcatata tgacctggcg gtggtgggca cagtggacgt 1140
gatccctctt tttgtgctga gggagcctct cggttggaac caagtgcagg tgggctatgg 1200
tatggctgca gggtacacca tcttcatcac cagcttcctg ggtgtcctgg tcttctcccg 1260
ctgctttcgg gacaccacca tgatcatgat tgggatggtc tcctttgggt caggagccct 1320
cctcttggct tttgtgaaag agacatacat gttctatatt gctcgagccg tcatgctgtt 1380
tgctctcatc cccgtcacaa ccatccgatc agctatgtcc aaactcataa agggctcctc 1440
ttatggaaag gtgttcgtca tactgcagct gtccttggct ctgaccggcg tggtgacatc 1500
caccttgtac aacaagatct accagctcac catggacatg tttgtgggct cctgctttgc 1560
tctctcctcc tttctctcct tcctggccat cattccaatt agcatcgtgg cctataaaca 1620
agtcccattg tcaccatatg gagacatcat agagaaatga agatgcttac ctgcaggaac 1680
tgaaaacatc agccatggcc aggcccccag aagacaaaag aagggaccag ggaactggtg 1740
acctaagcaa cccactgctt aagaaacctg cgttccagcc agagttggcc tcagaatgac 1800
ctgctctggc tcagggatcc ctggtggatg gggaaaagca ctttcctggt gatggaaaaa 1860
cgttctcagc tttaagacac ccccattagg cagacactgg gttctgtgac agcagagcat 1920
gaccttaagg gttacaggca ggctgcacac agcagtccca ggccctgtga ggggcttcag 1980
actccagcta cagcgagcct gccccttttc ttcaagggac tgtcttgagg gctccaaagt 2040
atagctaact agtcacctgg gtgctgtgct gaaagtccca tgggagaact caaagcgtgc 2100
attatcacag cctgagggga atgtggaagg gatgttttgt aagaactacc aacagttttg 2160
cacgaacaat gtcttttaaa ttaaaataaa accttgaaaa aagtcagctt tctttcctga 2220
gtcttcctta cctacaaaca ctcaggaggg ggatggagct caggcccttg tcttctgggt 2280
agttttgtta ctactgttgc ttttaagaag caaatgtcac aaggctttct tcaatgggat 2340
gttcaattga gtacttccag tcaacagtgc ttcccaaagt gggtggtgtg aaggaagagg 2400
aggtacatta agagctattt tatttgaggt agtcattttt ataaccttgt ttacttggat 2460
ttataaaagc agactcacct aataaaatca acattcattg taaaaaaaaa aaaaaaaa 2518
<210> 32
<211> 4791
<212> DNA
<213> Homo sapiens
<400> 32
ctgcttgtca aaaggcggca gcggagccgt gtgcgccggg agcgcggaac agcttgtcca 60
cccgccggcc ggaccagggc tcctgaacct agcccagctg gacggagaaa tggactctag 120
cctcctctga tagcctcatg ccaggccccg tgcacattgc tttgcttgcc tccctcaatc 180
ctcatagctt ctctttggga agcctttggg tctgaagtgt ctgtgagacc tcacagaaga 240
gcacccctgg gctccactta cctgccccct gctccttcag ggatggaggc aatggcggcc 300
agcacttccc tgcctgaccc tggagacttt gaccggaacg tgccccggat ctgtggggtg 360
tgtggagacc gagccactgg ctttcacttc aatgctatga cctgtgaagg ctgcaaaggc 420
ttcttcaggc gaagcatgaa gcggaaggca ctattcacct gccccttcaa cggggactgc 480
cgcatcacca aggacaaccg acgccactgc caggcctgcc ggctcaaacg ctgtgtggac 540
atcggcatga tgaaggagtt cattctgaca gatgaggaag tgcagaggaa gcgggagatg 600
atcctgaagc ggaaggagga ggaggccttg aaggacagtc tgcggcccaa gctgtctgag 660
gagcagcagc gcatcattgc catactgctg gacgcccacc ataagaccta cgaccccacc 720
tactccgact tctgccagtt ccggcctcca gttcgtgtga atgatggtgg agggagccat 780
ccttccaggc ccaactccag acacactccc agcttctctg gggactcctc ctcctcctgc 840
tcagatcact gtatcacctc ttcagacatg atggactcgt ccagcttctc caatctggat 900
ctgagtgaag aagattcaga tgacccttct gtgaccctag agctgtccca gctctccatg 960
ctgccccacc tggctgacct ggtcagttac agcatccaaa aggtcattgg ctttgctaag 1020
atgataccag gattcagaga cctcacctct gaggaccaga tcgtactgct gaagtcaagt 1080
gccattgagg tcatcatgtt gcgctccaat gagtccttca ccatggacga catgtcctgg 1140
acctgtggca accaagacta caagtaccgc gtcagtgacg tgaccaaagc cggacacagc 1200
ctggagctga ttgagcccct catcaagttc caggtgggac tgaagaagct gaacttgcat 1260
gaggaggagc atgtcctgct catggccatc tgcatcgtct ccccagatcg tcctggggtg 1320
caggacgccg cgctgattga ggccatccag gaccgcctgt ccaacacact gcagacgtac 1380
atccgctgcc gccacccgcc cccgggcagc cacctgctct atgccaagat gatccagaag 1440
ctagccgacc tgcgcagcct caatgaggag cactccaagc agtaccgctg cctctccttc 1500
cagcctgagt gcagcatgaa gctaacgccc cttgtgctcg aagtgtttgg caatgagatc 1560
tcctgactag gacagcctgt ggcggtgcct gggtggggct gctcctccag ggccacgtgc 1620
caggcccggg gctggcggct actcagcagc cctcctcacc ccgtctgggg ttcagcccct 1680
cctctgccac ctcccctatc cacccagccc attctctctc ctgtccaacc taaccccttt 1740
cctgcgggct tttccccggt cccttgagac ctcagccatg aggagttgct gtttgtttga 1800
caaagaaacc caagtggggg cagagggcag aggctggagg cagggccttg cccagagatg 1860
cctccaccgc tgcctaagtg gctgctgact gatgttgagg gaacagacag gagaaatgca 1920
tccattcctc agggacagag acacctgcac ctccccccac tgcaggcccc gcttgtccag 1980
cgcctagtgg ggtctccctc tcctgcctac tcacgataaa taatcggccc acagctccca 2040
ccccaccccc ttcagtgccc accaacatcc cattgccctg gttatattct cacgggcagt 2100
agctgtggtg aggtgggttt tcttcccatc actggagcac caggcacgaa cccacctgct 2160
gagagaccca aggaggaaaa acagacaaaa acagcctcac agaagaatat gacagctgtc 2220
cctgtcacca agctcacagt tcctcgccct gggtctaagg ggttggttga ggtggaagcc 2280
ctccttccac ggatccatgt agcaggactg aattgtcccc agtttgcaga aaagcacctg 2340
ccgacctcgt cctccccctg ccagtgcctt acctcctgcc caggagagcc agccctccct 2400
gtcctcctcg gatcaccgag agtagccgag agcctgctcc cccaccccct ccccagggga 2460
gagggtctgg agaagcagtg agccgcatct tctccatctg gcagggtggg atggaggaga 2520
agaattttca gaccccagcg gctgagtcat gatctccctg ccgcctcaat gtggttgcaa 2580
ggccgctgtt cacccacagg gctaagagct agcgctgccg caccccagag tgtgggaagg 2640
gagagcgggg cagtctcggg tggctagtca gagagagtgt ttgggggttc cgtgatgtag 2700
ggtaaggtgc cttcttattc tcactccacc acccaaaagt caaaaggtgc ctgtgaggca 2760
ggggcggagt gatacaactt caagtgcatg ctctctgcag ccagcccagc ccagctggtg 2820
ggaagcgtct gtccgtttac tccaaggtgg ggtctttgtg agagtgagct gtaggtgtgc 2880
gggaccggta cagaaaggcg ttcttcgagg tggatcacag aggcttcttc agatcagtgc 2940
ttgagtttgg ggaatgcggc cgcattccct gagtcaccag gaatgttaaa gtcagtggga 3000
acgtgactgc cccaactcct ggaagctgtg tccttgcacc tgcatccgta gttccctgaa 3060
aacccagaga ggaatcagac ttcacactgc aagagccttg gtgtccacct ggccccatgt 3120
ctctcagaat tcttcaggtg gaaaaacatc tgaaagccac gttccttact gcagaatagc 3180
atatatatcg cttaatctta aatttattag atatgagttg ttttcagact cagactccat 3240
ttgtattata gtctaatata cagggtagca ggtaccactg atttggagat atttatgggg 3300
ggagaactta cattgtgaaa cttctgtaca ttaattatta ttgctgttgt tattttacaa 3360
gggtctaggg agagaccctt gtttgatttt agctgcagaa cgtattggtc cagcttgctc 3420
ttcagtggga gaaaacactt gtaagttgct aaacgagtca atcccctcat tcaggaaaac 3480
tgacagagga gggcgtgact cacccaagca tatataacta gctagaagtg ggccaggaca 3540
ggcccggcgc ggtggctcac gcctgtaatc ccagcagttt gggaggtcga ggtaggtgga 3600
tcacctgagg tcgggagttc gagaccaacc tgaccaacat ggagaaaccc tgtctctatt 3660
aaaaatacaa aaaaaaaaaa aaaaaaaata gccgggcatg gtggcgcaag cctgtaatcc 3720
cagctactca ggaggctgag gcagaagaat tgaacccagg aggtggaggt tgcagtgagc 3780
tgagatcgtg ccgttactct ccaacctgga caacaagagc gaaactccgt cttagaagtg 3840
gaccaggaca ggaccagatt ttggagtcat ggtccggtgt ccttttcact acaccatgtt 3900
tgagctcaga cccccactct cattccccag gtggctgacc cagtccctgg gggaagccct 3960
ggatttcaga aagagcaagt ctggatctgg gaccctttcc ttccttccct ggcttgtaac 4020
tccaccaacc catcagaagg agaaggaagg agactcacct ctgcctcaat gtgaatcaga 4080
ccctacccca ccacgatgtg gccctggcct gctgggctct ccacctcagc cttggataat 4140
gctgttgcct catctataac atgcatttgt ctttgtaatg tcaccacctt cccagctctc 4200
cctctggccc tgccttcttc ggggaactcc tggaaatatc agttactcag ccctgggccc 4260
caccacctag gccactcctc caaaggaagt ctaggagctg ggaggaaaag aaaagagggg 4320
aaaatgagtt tttatggggc tgaacgggga gaaaaggtca tcatcgattc tactttagaa 4380
tgagagtgtg aaatagacat ttgtaaatgt aaaactttta aggtatatca ttataactga 4440
aggagaaggt gccccaaaat gcaagatttt ccacaagatt cccagagaca ggaaaatcct 4500
ctggctggct aactggaagc atgtaggaga atccaagcga ggtcaacaga gaaggcagga 4560
atgtgtggca gatttagtga aagctagaga tatggcagcg aaaggatgta aacagtgcct 4620
gctgaatgat ttccaaagag aaaaaaagtt tgccagaagt ttgtcaagtc aaccaatgta 4680
gaaagctttg cttatggtaa taaaaatggc tcatacttat atagcactta ctttgttgca 4740
agtactgctg taaataaatg ctttatgcaa accaaaaaaa aaaaaaaaaa a 4791
<210> 33
<211> 1869
<212> DNA
<213> Homo sapiens
<400> 33
ggagtttgag tgagagatat agggaaggaa gggaagtaag cagtcacaga cgctggcggc 60
caccagaagt ttgagcctct ttggtagcag gaggctggaa gaaaggacag aagtagctct 120
ggctgtgatg gggatcttac tgggcctgct actcctgggg cacctaacag tggacactta 180
tggccgtccc atcctggaag tgccagagag tgtaacagga ccttggaaag gggatgtgaa 240
tcttccctgc acctatgacc ccctgcaagg ctacacccaa gtcttggtga agtggctggt 300
acaacgtggc tcagaccctg tcaccatctt tctacgtgac tcttctggag accatatcca 360
gcaggcaaag taccagggcc gcctgcatgt gagccacaag gttccaggag atgtatccct 420
ccaattgagc accctggaga tggatgaccg gagccactac acgtgtgaag tcacctggca 480
gactcctgat ggcaaccaag tcgtgagaga taagattact gagctccgtg tccagaaact 540
ctctgtctcc aagcccacag tgacaactgg cagcggttat ggcttcacgg tgccccaggg 600
aatgaggatt agccttcaat gccaggctcg gggttctcct cccatcagtt atatttggta 660
taagcaacag actaataacc aggaacccat caaagtagca accctaagta ccttactctt 720
caagcctgcg gtgatagccg actcaggctc ctatttctgc actgccaagg gccaggttgg 780
ctctgagcag cacagcgaca ttgtgaagtt tgtggtcaaa gactcctcaa agctactcaa 840
gaccaagact gaggcaccta caaccatgac ataccccttg aaagcaacat ctacagtgaa 900
gcagtcctgg gactggacca ctgacatgga tggctacctt ggagagacca gtgctgggcc 960
aggaaagagc ctgcctgtct ttgccatcat cctcatcatc tccttgtgct gtatggtggt 1020
ttttaccatg gcctatatca tgctctgtcg gaagacatcc caacaagagc atgtctacga 1080
agcagccagg gcacatgcca gagaggccaa cgactctgga gaaaccatga gggtggccat 1140
cttcgcaagt ggctgctcca gtgatgagcc aacttcccag aatctgggca acaactactc 1200
tgatgagccc tgcataggac aggagtacca gatcatcgcc cagatcaatg gcaactacgc 1260
ccgcctgctg gacacagttc ctctggatta tgagtttctg gccactgagg gcaaaagtgt 1320
ctgttaaaaa tgccccatta ggccaggatc tgctgacata attgcctagt cagtccttgc 1380
cttctgcatg gccttcttcc ctgctacctc tcttcctgga tagcccaaag tgtccgccta 1440
ccaacactgg agccgctggg agtcactggc tttgccctgg aatttgccag atgcatctca 1500
agtaagccag ctgctggatt tggctctggg cccttctagt atctctgccg ggggcttctg 1560
gtactcctct ctaaatacca gagggaagat gcccatagca ctaggacttg gtcatcatgc 1620
ctacagacac tattcaactt tggcatcttg ccaccagaag acccgaggga ggctcagctc 1680
tgccagctca gaggaccagc tatatccagg atcatttctc tttcttcagg gccagacagc 1740
ttttaattga aattgttatt tcacaggcca gggttcagtt ctgctcctcc actataagtc 1800
taatgttctg actctctcct ggtgctcaat aaatatctaa tcataacagc aaaaaaaaaa 1860
aaaaaaaaa 1869
<210> 34
<211> 4190
<212> DNA
<213> Homo sapiens
<400> 34
atatgtagcc ttttcatttt catgaaagtg aagtgatttt tagaattctt agttgttttc 60
tttagaagaa catttctagg gaataataca agaagattta ggaatcattg aagttataaa 120
tctttggaat gagcaaactc agaatggtgc tacttgaaga ctctggatct gctgacttca 180
gaagacattt tgtcaacttg agtcccttca ccattactgt ggtcttactt ctcagtgcct 240
gttttgtcac cagttctctt ggaggaacag acaaggagct gaggctagtg gatggtgaaa 300
acaagtgtag cgggagagtg gaagtgaaag tccaggagga gtggggaacg gtgtgtaata 360
atggctggag catggaagcg gtctctgtga tttgtaacca gctgggatgt ccaactgcta 420
tcaaagcccc tggatgggct aattccagtg caggttctgg acgcatttgg atggatcatg 480
tttcttgtcg tgggaatgag tcagctcttt gggattgcaa acatgatgga tggggaaagc 540
atagtaactg tactcaccaa caagatgctg gagtgacctg ctcagatgga tccaatttgg 600
aaatgaggct gacgcgtgga gggaatatgt gttctggaag aatagagatc aaattccaag 660
gacggtgggg aacagtgtgt gatgataact tcaacataga tcatgcatct gtcatttgta 720
gacaacttga atgtggaagt gctgtcagtt tctctggttc atctaatttt ggagaaggct 780
ctggaccaat ctggtttgat gatcttatat gcaacggaaa tgagtcagct ctctggaact 840
gcaaacatca aggatgggga aagcataact gtgatcatgc tgaggatgct ggagtgattt 900
gctcaaaggg agcagatctg agcctgagac tggtagatgg agtcactgaa tgttcaggaa 960
gattagaagt gagattccaa ggagaatggg ggacaatatg tgatgacggc tgggacagtt 1020
acgatgctgc tgtggcatgc aagcaactgg gatgtccaac tgccgtcaca gccattggtc 1080
gagttaacgc cagtaaggga tttggacaca tctggcttga cagcgtttct tgccagggac 1140
atgaacctgc tatctggcaa tgtaaacacc atgaatgggg aaagcattat tgcaatcaca 1200
atgaagatgc tggcgtgaca tgttctgatg gatcagatct ggagctaaga cttagaggtg 1260
gaggcagccg ctgtgctggg acagttgagg tggagattca gagactgtta gggaaggtgt 1320
gtgacagagg ctggggactg aaagaagctg atgtggtttg caggcagctg ggatgtggat 1380
ctgcactcaa aacatcttat caagtgtact ccaaaatcca ggcaacaaac acatggctgt 1440
ttctaagtag ctgtaacgga aatgaaactt ctctttggga ctgcaagaac tggcaatggg 1500
gtggacttac ctgtgatcac tatgaagaag ccaaaattac ctgctcagcc cacagggaac 1560
ccagactggt tggaggggac attccctgtt ctggacgtgt tgaagtgaag catggtgaca 1620
cgtggggctc catctgtgat tcggacttct ctctggaagc tgccagcgtt ctatgcaggg 1680
aattacagtg tggcacagtt gtctctatcc tggggggagc tcactttgga gagggaaatg 1740
gacagatctg ggctgaagaa ttccagtgtg agggacatga gtcccatctt tcactctgcc 1800
cagtagcacc ccgcccagaa ggaacttgta gccacagcag ggatgttgga gtagtctgct 1860
caagatacac agaaattcgc ttggtgaatg gcaagacccc gtgtgagggc agagtggagc 1920
tcaaaacgct tggtgcctgg ggatccctct gtaactctca ctgggacata gaagatgccc 1980
atgttctttg ccagcagctt aaatgtggag ttgccctttc taccccagga ggagcacgtt 2040
ttggaaaagg aaatggtcag atctggaggc atatgtttca ctgcactggg actgagcagc 2100
acatgggaga ttgtcctgta actgctctag gtgcttcatt atgtccttca gagcaagtgg 2160
cctctgtaat ctgctcagga aaccagtccc aaacactgtc ctcgtgcaat tcatcgtctt 2220
tgggcccaac aaggcctacc attccagaag aaagtgctgt ggcctgcata gagagtggtc 2280
aacttcgcct ggtaaatgga ggaggtcgct gtgctgggag agtagagatc tatcatgagg 2340
gctcctgggg caccatctgt gatgacagct gggacctgag tgatgcccac gtggtttgca 2400
gacagctggg ctgtggagag gccattaatg ccactggttc tgctcatttt ggggaaggaa 2460
cagggcccat ctggctggat gagatgaaat gcaatggaaa agaatcccgc atttggcagt 2520
gccattcaca cggctggggg cagcaaaatt gcaggcacaa ggaggatgcg ggagttatct 2580
gctcagaatt catgtctctg agactgacca gtgaagccag cagagaggcc tgtgcagggc 2640
gtctggaagt tttttacaat ggagcttggg gcactgttgg caagagtagc atgtctgaaa 2700
ccactgtggg tgtggtgtgc aggcagctgg gctgtgcaga caaagggaaa atcaaccctg 2760
catctttaga caaggccatg tccattccca tgtgggtgga caatgttcag tgtccaaaag 2820
gacctgacac gctgtggcag tgcccatcat ctccatggga gaagagactg gccagcccct 2880
cggaggagac ctggatcaca tgtgacaaca agataagact tcaggaagga cccacttcct 2940
gttctggacg tgtggagatc tggcatggag gttcctgggg gacagtgtgt gatgactctt 3000
gggacttgga cgatgctcag gtggtgtgtc aacaacttgg ctgtggtcca gctttgaaag 3060
cattcaaaga agcagagttt ggtcagggga ctggaccgat atggctcaat gaagtgaagt 3120
gcaaagggaa tgagtcttcc ttgtgggatt gtcctgccag acgctggggc catagtgagt 3180
gtgggcacaa ggaagacgct gcagtgaatt gcacagatat ttcagtgcag aaaaccccac 3240
aaaaagccac aacaggtcgc tcatcccgtc agtcatcctt tattgcagtc gggatccttg 3300
gggttgttct gttggccatt ttcgtcgcat tattcttctt gactaaaaag cgaagacaga 3360
gacagcggct tgcagtttcc tcaagaggag agaacttagt ccaccaaatt caataccggg 3420
agatgaattc ttgcctgaat gcagatgatc tggacctaat gaattcctca gaaaattccc 3480
atgagtcagc tgatttcagt gctgctgaac taatttctgt gtctaaattt cttcctattt 3540
ctggaatgga aaaggaggcc attctgagcc acactgaaaa ggaaaatggg aatttataac 3600
ccagtgagtt cagcctttaa gataccttga tgaagacctg gactattgaa tggagcagaa 3660
attcacctct ctcactgact attacagttg catttttatg gagttcttct tctcctagga 3720
ttcctaagac tgctgctgaa tttataaaaa ttaagtttgt gaatgtgact acttagtggt 3780
gtatatgaga ctttcaaggg aattaaataa ataaataaga atgttattga tttgagtttg 3840
ctttaattac ttgtccttaa ttctattaat ttctaaatgg gcttcctaat tttttgtaga 3900
gtttcctaga tgtattataa tgtgttttat ttgacagtgt ttcaatttgc atatacagta 3960
ctgtatattt tttcttattt ggtttgaata attttcctat taccaaataa aaataaattt 4020
atttttactt tagtttttct aagacaggaa aagttaatga tattgaaggg tctgtaaata 4080
atatatggct aactttataa ggcatgactc acaacgattc tttaactgct ttttgttact 4140
gtaattctgt tcactagaat aaaatgcaga gccacacctg gtgagggcac 4190
<210> 35
<211> 985
<212> DNA
<213> Homo sapiens
<400> 35
caaaccatgg gaggctcctc tcctagaccc tgcatcctga aagctgcgta cctgagagcc 60
tgcggtctgg ctgcagggac acacccaagg ggaggagctg caatcgtgtc tggggcccca 120
gcccaggctg gccggagctc ctgtttcccg ctgctctgct gcctgcccgg ggtaccaaca 180
tggcccagaa gcgtcctgcc tgcaccctga agcctgagtg tgtccagcag ctgctggttt 240
gctcccagga ggccaagaag tcagcctact gcccctacag tcactttcct gtgggggctg 300
ccctgctcac ccaggagggg agaatcttca aagggtgcaa catagaaaat gcctgctacc 360
cgctgggcat ctgtgctgaa cggaccgcta tccagaaggc cgtctcagaa gggtacaagg 420
atttcagggc aattgctatc gccagtgaca tgcaagatga ttttatctct ccatgtgggg 480
cctgcaggca agtcatgaga gagtttggca ccaactggcc cgtgtacatg accaagccgg 540
atggtacgta tattgtcatg acggtccagg agctgctgcc ctcctccttt gggcctgagg 600
acctgcagaa gacccagtga cagccagaga atgcccactg cctgtaacag ccacctggag 660
aacttcataa agatgtctca cagccctggg gacacctgcc cagtgggccc cagccctaca 720
gggactgggc aaagatgatg tttccagatt acactccagc ctgagtcagc acccctccta 780
gcaacctgcc ttgggactta gaacaccgcc gccccctgcc ccacctttcc tttccttcct 840
gtgggccctc tttcaaagtc cagcctagtc tggactgctt ccccatcagc cttcccaagg 900
ttctatcctg ttccgagcaa cttttctaat tataaacatc acagaacatc ctggatcaaa 960
aaaaaaaaaa aaaaaaaaaa aaaaa 985
<210> 36
<211> 1184
<212> DNA
<213> Homo sapiens
<400> 36
cacagagccc gggccgcagg cacctcctcg ccagctcttc cgctcctctc acagccgcca 60
gacccgcctg ctgagcccca tggcccgcgc tgctctctcc gccgccccca gcaatccccg 120
gctcctgcga gtggcactgc tgctcctgct cctggtagcc gctggccggc gcgcagcagg 180
agcgtccgtg gccactgaac tgcgctgcca gtgcttgcag accctgcagg gaattcaccc 240
caagaacatc caaagtgtga acgtgaagtc ccccggaccc cactgcgccc aaaccgaagt 300
catagccaca ctcaagaatg ggcggaaagc ttgcctcaat cctgcatccc ccatagttaa 360
gaaaatcatc gaaaagatgc tgaacagtga caaatccaac tgaccagaag ggaggaggaa 420
gctcactggt ggctgttcct gaaggaggcc ctgcccttat aggaacagaa gaggaaagag 480
agacacagct gcagaggcca cctggattgt gcctaatgtg tttgagcatc gcttaggaga 540
agtcttctat ttatttattt attcattagt tttgaagatt ctatgttaat attttaggtg 600
taaaataatt aagggtatga ttaactctac ctgcacactg tcctattata ttcattcttt 660
ttgaaatgtc aaccccaagt tagttcaatc tggattcata tttaatttga aggtagaatg 720
ttttcaaatg ttctccagtc attatgttaa tatttctgag gagcctgcaa catgccagcc 780
actgtgatag aggctggcgg atccaagcaa atggccaatg agatcattgt gaaggcaggg 840
gaatgtatgt gcacatctgt tttgtaactg tttagatgaa tgtcagttgt tatttattga 900
aatgatttca cagtgtgtgg tcaacatttc tcatgttgaa actttaagaa ctaaaatgtt 960
ctaaatatcc cttggacatt ttatgtcttt cttgtaaggc atactgcctt gtttaatggt 1020
agttttacag tgtttctggc ttagaacaaa ggggcttaat tattgatgtt ttcatagaga 1080
atataaaaat aaagcactta tagaaaaaac tcgtttgatt tttgggggga aacaagggct 1140
acctttactg gaaaatctgg tgatttataa aaaaaaaaaa aaaa 1184
<210> 37
<211> 1647
<212> DNA
<213> Homo sapiens
<400> 37
gaagatccaa gcaggcggag ccgcggtctg gtccgcgggg taggcggggc gcaagagtgt 60
tcccgggggc ggggggccga cccgcgtcta aaggtttccg cgattcaccc gccggcgcct 120
ggcctggccc agttgcacca cgagcgctgc ggacactcgg ggcggcagtc ggtctgtcag 180
tcctcccgcc aggtcccgcg gcccgcacct gccgcccgca cctgcagctc cgcacctgcg 240
gccagtgcct actgccctct cttgccgccc gcacctgcag ccccgcacct gccgcttgca 300
cctgcagccc cgcgctctac ccggttcaag catggctgac caggcgccct tcgacacgga 360
cgtcaacacc ctgacccgct tcgtcatgga ggagggcagg aaggcccgcg gcacgggcga 420
gttgacccag ctgctcaact cgctctgcac agcagtcaaa gccatctctt cggcggtgcg 480
caaggcgggc atcgcgcacc tctatggcat tgctggttct accaacgtga caggtgatca 540
agttaagaag ctggacgtcc tctccaacga cctggttatg aacatgttaa agtcatcctt 600
tgccacgtgt gttctcgtgt cagaagaaga taaacacgcc atcatagtgg aaccggagaa 660
aaggggtaaa tatgtggtct gttttgatcc ccttgatgga tcttccaaca tcgattgcct 720
tgtgtccgtt ggaaccattt ttggcatcta tagaaagaaa tcaactgatg agccttctga 780
gaaggatgct ctgcaaccag gccggaacct ggtggcagcc ggctacgcac tgtatggcag 840
tgccaccatg ctggtccttg ccatggactg tggggtcaac tgcttcatgc tggacccggc 900
catcggggag ttcattttgg tggacaagga tgtgaagata aaaaagaaag gtaaaatcta 960
cagccttaac gagggctacg ccagggactt tgaccctgcc gtcactgagt acatccagag 1020
gaagaagttc cccccagata attcagctcc ttatggggcc cggtatgtgg gctccatggt 1080
ggctgatgtt catcgcactc tggtctacgg agggatattt ctgtaccccg ctaacaagaa 1140
gagccccaat ggaaagctga gactgctgta cgaatgcaac cccatggcct acgtcatgga 1200
gaaggctggg ggaatggcca ccactgggaa ggaggccgtg ttagacgtca ttcccacaga 1260
cattcaccag agggcgccgg tgatcttggg atcccccgac gacgtgctcg agttcctgaa 1320
ggtgtatgag aagcactctg cccagtgagc acctgccctg cctgcatccg gagaattgcc 1380
tctacctgga ccttttgtct cacacagcag taccctgacc tgctgtgcac cttacattcc 1440
tagagagcag aaataaaaag catgactatt tccaccatca aatgctgtag aatgcttggc 1500
actccctaac caaatgctgt ctccataatg ccactggtgt taagatatat tttgagtgga 1560
tggaggagaa ataaacttat tcctccttaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1620
aaaaaaaaaa aaaaaaaaaa aaaaaaa 1647
<210> 38
<211> 1814
<212> DNA
<213> Homo sapiens
<400> 38
attctcagca cagcctttaa ggttccaaac atctgctaga agaggaatgc agatttaaac 60
tgagtgaggt gtggagtggg ggaagttgat tgggtctaga ccaaagaact ttgaggaact 120
tgcccagagc cctgcatgca tcagacctac agcagacatt gcaggcctga agaaaggtgg 180
tcacaagagg ggtggaacat tcctgcaaat ggtttcaata tatgcagatg tctcaatata 240
ggaatgaaat tacgtctttg gaacaactta aataagtcaa atatacttgg agctttaaaa 300
attaaaagga gagagattcg agcacctttt ctgctgccat gacaaccatg caaggaatgg 360
aacaggccat gccaggggct ggccctggtg tgccccagct gggaaacatg gctgtcatac 420
attcacatct gtggaaagga ttgcaagaga agttcttgaa gggagaaccc aaagtccttg 480
gggttgtgca gattctgact gccctgatga gccttagcat gggaataaca atgatgtgta 540
tggcatctaa tacttatgga agtaacccta tttccgtgta tatcgggtac acaatttggg 600
ggtcagtaat gtttattatt tcaggatcct tgtcaattgc agcaggaatt agaactacaa 660
aaggcctggt ccgaggtagt ctaggaatga atatcaccag ctctgtactg gctgcatcag 720
ggatcttaat caacacattt agcttggcgt tttattcatt ccatcaccct tactgtaact 780
actatggcaa ctcaaataat tgtcatggga ctatgtccat cttaatgggt ctggatggca 840
tggtgctcct cttaagtgtg ctggaattct gcattgctgt gtccctctct gcctttggat 900
gtaaagtgct ctgttgtacc cctggtgggg ttgtgttaat tctgccatca cattctcaca 960
tggcagaaac agcatctccc acaccactta atgaggtttg aggccaccaa aagatcaaca 1020
gacaaatgct ccagaaatct atgctgactg tgacacaaga gcctcacatg agaaattacc 1080
agtatccaac ttcgatactg atagacttgt tgatattatt attatatgta atccaattat 1140
gaactgtgtg tgtatagaga gataataaat tcaaaattat gttctcattt ttttccctgg 1200
aactcaataa ctcatttcac tggctcttta tcgagagtac tagaagttaa attaataaat 1260
aatgcattta atgaggcaac agcacttgaa agtttttcat tcatcataag aactttatat 1320
aaaggcatta cattggcaaa taaggtttgg aagcagaaga gcaaaaaaaa gatattgtta 1380
aaatgaggcc tccatgcaaa acacatactt ccctcccatt tatttaactt tttttttctc 1440
ctacctatgg ggaccaaagt gctttttcct tcaggaagtg gagatgcatg gccatctccc 1500
cctccctttt tccttctcct gcttttcttt ccccatagaa agtaccttga agtagcacag 1560
tccgtccttg catgtgcacg agctatcatt tgagtaaaag tatacatgga gtaaaaatca 1620
tattaagcat cagattcaac ttatattttc tatttcatct tcttcctttc ccttctccca 1680
ccttctactg ggcataatta tatcttaatc atatatggaa atgtgcaaca tatggtattt 1740
gttaaatacg tttgttttta ttgcagagca aaaataaatc aaattagaag caataaaaaa 1800
aaaaaaaaaa aaaa 1814
<210> 39
<211> 3316
<212> DNA
<213> Homo sapiens
<400> 39
atctgctcct gtaagcccag agaggcccag ggacaacttc cactttattc tggatgtttt 60
cacttttggg acatcctgtt ctgagtcaag attcctcctt ctgaacatgg gactttccag 120
aaggaccaca gctcctcccg tgcatccact cggcctggga ggttctggat tttggctgtc 180
gagggagttt gcctgcctct ccagagaaag atggtcatga ggcccctgtg gagtctgctt 240
ctctgggaag ccctacttcc cattacagtt actggtgccc aagtgctgag caaagtcggg 300
ggctcggtgc tgctggtggc agcgcgtccc cctggcttcc aagtccgtga ggctatctgg 360
cgatctctct ggccttcaga agagctcctg gccacgtttt tccgaggctc cctggagact 420
ctgtaccatt cccgcttcct gggccgagcc cagctacaca gcaacctcag cctggagctc 480
gggccgctgg agtctggaga cagcggcaac ttctccgtgt tgatggtgga cacaaggggc 540
cagccctgga cccagaccct ccagctcaag gtgtacgatg cagtgcccag gcccgtggta 600
caagtgttca ttgctgtaga aagggatgct cagccctcca agacctgcca ggttttcttg 660
tcctgttggg cccccaacat cagcgaaata acctatagct ggcgacggga gacaaccatg 720
gactttggta tggaaccaca cagcctcttc acagacggac aggtgctgag catttccctg 780
ggaccaggag acagagatgt ggcctattcc tgcattgtct ccaaccctgt cagctgggac 840
ttggccacag tcacgccctg ggatagctgt catcatgagg cagcaccagg gaaggcctcc 900
tacaaagatg tgctgctggt ggtggtgcct gtctcgctgc tcctgatgct ggttactctc 960
ttctctgcct ggcactggtg cccctgctca gggaaaaaga aaaaggatgt ccatgctgac 1020
agagtgggtc cagagacaga gaaccccctt gtgcaggatc tgccataaag gacaatatga 1080
actgatgcct ggactatcag taaccccact gcacaggcac acgatgctct gggacataac 1140
tggtgcctgg aaatcaccat ggtcctcata tctcccatgg gaatcctgtc ctgcctcgaa 1200
ggagcagcct gggcagccat cacaccacga ggacaggaag caccagcacg tttcacacct 1260
cccccttccc tctcccatct tctcatatcc tggctcttct ctgggcaaga tgagccaagc 1320
agaacattcc atccaggaca ctggaagttc tccaggatcc agatccatgg ggacattaat 1380
agtccaaggc attccctccc ccaccactat tcataaagta ttaaccaact ggcaccaagg 1440
aattgcctcc agcctgagtc ctaggctcta aaagatatta catatttgaa ctaatagagg 1500
aactctgagt cacccatgcc agcatcagct tcagccccag accctgcagt ttgagatctg 1560
atgcttcctg agggccaagg cattgctgta agaaaaggtc tagaaatagg tgaaagtgag 1620
aggtggggga caggggtttc tctttctggc ctaaggactt tcaggtaatc agagttcatg 1680
ggccctcaaa ggtaaattgc agttgtagac accgaggatg gttgacaacc catggttgag 1740
atgggcaccg ttttgcagga aacaccatat taatagacat cctcaccatc tccatccgct 1800
ctcacgcctc ctgcaggatc tgggagtgag ggtggagagt ctttcctcac gctccagcac 1860
agtggccagg aaaagaaata ctgaatttgc cccagccaac aggacgttct tgcacaactt 1920
caagaaaagc agctcagctc aggatgagtc ttcctgcctg aaactgagag agtgaagaac 1980
cataaaacgc tatgcagaag gaacattatg gagagaaagg gtactgaggc actctagaat 2040
ctgccacatt cattttcaaa tgcaaatgca gaagacttac cttagttcaa ggggagggga 2100
caaagacccc acagcccaac agcaggactg tagaggtcac tctgactcca tcaaactttt 2160
tattgtggcc atcttaggaa aatacattct gcccctgaat gattctgtct agaaaagctc 2220
tggagtattg atcactactg gaaaaacact taaggagcta aacttacctt cggggattat 2280
tagctgataa ggttcacagt ttctctcacc caggtgtaac tggatttttt ctggggcctc 2340
aatccagtct tgataacagc gaggaaagag gtattgaaga aacaggggtg ggtttgaagt 2400
actattttcc cagggtggct tcaatctccc cacctaggat gtcagccctg tccaaggacc 2460
ttccctcttc tccccagttc ctgggcaatc acttcacctt ggacaaagga tcagcacagc 2520
tggcctccag atccacatca ccactcttcc actcgattgt tcccagatcc tccctgcctg 2580
gcctgctcag aggttccctg ttggtaacct ggctttatca aattctcatc cctttcccac 2640
acccacttct ctcctatcac cttcccccaa gattacctga acagggtcca tggccactca 2700
acctgtcagc ttgcaccatc cccacctgcc acctacagtc aggccacatg cctggtcact 2760
gaatcatgca aaactggcct cagtccctaa aaatgatgtg gaaaggaaag cccaggatct 2820
gacaatgagc cctggtggat ttgtggggaa aaaatacaca gcactcccca cctttctttc 2880
gttcatctcc agggccccac ctcagatcaa agcagctctg gatgagatgg gacctgcagc 2940
tctccctcca caaggtgact cttagcaacc tcatttcgac agtggtttgt agcgtggtgc 3000
accagggcct tgttgaacag atccacactg ctctaataaa gttcccatcc ttaatgactc 3060
acttgtcaac tagtggacta attaaccctc caccaaaaaa acacaaagtg cttctgtgag 3120
accaattttg tgctaatgag cattgagact gatgctttgt aagtcacacc acaacaaata 3180
ttgattgagg gcgctgcatg tgctgggtac atttcttggc acttgggaat cagtagtcaa 3240
gcgaaaccct tgcctttgag agtttatggt ctggataata taaataaaca agtaagcata 3300
aaaaaaaaaa aaaaaa 3316
<210> 40
<211> 1886
<212> DNA
<213> Homo sapiens
<400> 40
gttagaggcg gcttgtgtcc acgggacgcg ggcggatctt ctccggccat gaggaagcca 60
gccgctggct tccttccctc actcctgaag gtgctgctcc tgcctctggc acctgccgca 120
gcccaggatt cgactcaggc ctccactcca ggcagccctc tctctcctac cgaatacgaa 180
cgcttcttcg cactgctgac tccaacctgg aaggcagaga ctacctgccg tctccgtgca 240
acccacggct gccggaatcc cacactcgtc cagctggacc aatatgaaaa ccacggctta 300
gtgcccgatg gtgctgtctg ctccaacctc ccttatgcct cctggtttga gtctttctgc 360
cagttcactc actaccgttg ctccaaccac gtctactatg ccaagagagt cctgtgttcc 420
cagccagtct ctattctctc acctaacact ctcaaggaga tagaagcttc agctgaagtc 480
tcacccacca cgatgacctc ccccatctca ccccacttca cagtgacaga acgccagacc 540
ttccagccct ggcctgagag gctcagcaac aacgtggaag agctcctaca atcctccttg 600
tccctgggag gccaggagca agcgccagag cacaagcagg agcaaggagt ggagcacagg 660
caggagccga cacaagaaca caagcaggaa gaggggcaga aacaggaaga gcaagaagag 720
gaacaggaag aggagggaaa gcaggaagaa ggacagggga ctaaggaggg acgggaggct 780
gtgtctcagc tgcagacaga ctcagagccc aagtttcact ctgaatctct atcttctaac 840
ccttcctctt ttgctccccg ggtacgagaa gtagagtcta ctcctatgat aatggagaac 900
atccaggagc tcattcgatc agcccaggaa atagatgaaa tgaatgaaat atatgatgag 960
aactcctact ggagaaacca aaaccctggc agcctcctgc agctgcccca cacagaggcc 1020
ttgctggtgc tgtgctattc gatcgtggag aatacctgca tcataacccc cacagccaag 1080
gcctggaagt acatggagga ggagatcctt ggtttcggga agtcggtctg tgacagcctt 1140
gggcggcgac acatgtctac ctgtgccctc tgtgacttct gctccttgaa gctggagcag 1200
tgccactcag aggccagcct gcagcggcaa caatgcgaca cctcccacaa gactcccttt 1260
gtcagcccct tgcttgcctc ccagagcctg tccatcggca accaggtagg gtccccagaa 1320
tcaggccgct tttacgggct ggatttgtac ggtgggctcc acatggactt ctggtgtgcc 1380
cggcttgcca cgaaaggctg tgaagatgtc cgagtctctg ggtggctcca gactgagttc 1440
cttagcttcc aggatgggga tttccctacc aagatttgtg acacagacta tatccagtac 1500
ccaaactact gttccttcaa aagccagcag tgtctgatga gaaaccgcaa tcggaaggtg 1560
tcccgcatga gatgtctgca gaatgagact tacagtgcgc tgagccctgg caaaagtgag 1620
gacgttgtgc ttcgatggag ccaggagttc agcaccttga ctctaggcca gttcggatga 1680
gctggcgtct attctgccca caccccagcc caacctgccc acgttctcta ttgttttgag 1740
accccattgc tttcaggctg ccccttctgg gtctgttact cggcccctac tcacatttcc 1800
ttgggttgga gcaacagtcc cagagagggc cacggtggga gctgcgccct ccttaaaaga 1860
tgactttaca taaaatgttg atcttc 1886
<210> 41
<211> 2781
<212> DNA
<213> Homo sapiens
<400> 41
gcagtcagag actttccctg cccctcgctg ggaaagaaca ttaggaatgc cttttagtgc 60
cttgcttcct gaactagctc acagtagccc ggcggcccag ggcaatccga ccacatttca 120
ctctcaccgc tgtaggaatc cagatgcagg ccaagtacag cagcacgagg gacatgctgg 180
atgatgatgg ggacaccacc atgagcctgc attctcaagg ctctgccaca actcggcatc 240
cagagccccg gcgcacagag cacagggctc cctcttcaac gtggcgacca gtggccctga 300
ccctgctgac tttgtgcttg gtgctgctga tagggctggc agccctgggg cttttgtttt 360
ttcagtacta ccagctctcc aatactggtc aagacaccat ttctcaaatg gaagaaagat 420
taggaaatac gtcccaagag ttgcaatctc ttcaagtcca gaatataaag cttgcaggaa 480
gtctgcagca tgtggctgaa aaactctgtc gtgagctgta taacaaagct ggagcacaca 540
ggtgcagccc ttgtacagaa caatggaaat ggcatggaga caattgctac cagttctata 600
aagacagcaa aagttgggag gactgtaaat atttctgcct tagtgaaaac tctaccatgc 660
tgaagataaa caaacaagaa gacctggaat ttgccgcgtc tcagagctac tctgagtttt 720
tctactctta ttggacaggg cttttgcgcc ctgacagtgg caaggcctgg ctgtggatgg 780
atggaacccc tttcacttct gaactgttcc atattataat agatgtcacc agcccaagaa 840
gcagagactg tgtggccatc cttaatggga tgatcttctc aaaggactgc aaagaattga 900
agcgttgtgt ctgtgagaga agggcaggaa tggtgaagcc agagagcctc catgtccccc 960
ctgaaacatt aggcgaaggt gactgattcg ccctctgcaa ctacaaatag cagagtgagc 1020
caggcggtgc caaagcaagg gctagttgag acattgggaa atggaacata atcaggaaag 1080
actatctctc tgactagtac aaaatgggtt ctcgtgtttc ctgttcagga tcaccagcat 1140
ttctgagctt gggtttatgc acgtatttaa cagtcacaag aagtcttatt tacatgccac 1200
caaccaacct cagaaaccca taatgtcatc tgccttcttg gcttagagat aacttttagc 1260
tctctttctt ctcaatgtct aatatcacct ccctgttttc atgtcttcct tacacttggt 1320
ggaataagaa actttttgaa gtagaggaaa tacattgagg taacatcctt ttctctgaca 1380
gtcaagtagt ccatcagaaa ttggcagtca cttcccagat tgtaccagca aatacacaag 1440
gaattctttt tgtttgtttc agttcatact agtcccttcc caatccatca gtaaagaccc 1500
catctgcctt gtccatgccg tttcccaaca gggatgtcac ttgatatgag aatctcaaat 1560
ctcaatgcct tataagcatt ccttcctgtg tccattaaga ctctgataat tgtctcccct 1620
ccataggaat ttctcccagg aaagaaatat atccccatct ccgtttcata tcagaactac 1680
cgtccccgat attcccttca gagagattaa agaccagaaa aaagtgagcc tcttcatctg 1740
cacctgtaat agtttcagtt cctattttct tccattgacc catatttata cctttcaggt 1800
actgaagatt taataataat aaatgtaaat actgtgaagt gtgtgtgatt ttacaatgga 1860
cttatggttg gtgggaaaat tcagcatgga aatgcttttc aaaatatgat agcggtcatt 1920
attttgattg tgccttactg aaagtttttg gggaatttac aagagtactg attacatgat 1980
tatctggaga aaataagatg tctttgaaat acgtgttggc ttcaagaaaa cagttttaac 2040
gttttcctaa aatgaaatct tttgaggtga gcttatggca tcaacacatg gttgatgagg 2100
aagctgagtt gcattagtgc acatgatttc cagtcaggtc atgggaaatg aacagagaca 2160
gtgacatctt tgtagctgct cctttgtgag gcacttcttt cttgagacga ctccatgcac 2220
aaatataaca gggatcattg ggaatgacac catcacagcc accaagttta ttggtttact 2280
gataaatcaa ttttgagggt tttatgctag aaaagataac attataaatc tttgtttttc 2340
aacagtggaa actgaggtgc ttcagttttg tttttcataa acatctatct catggtaaaa 2400
tgacgtatag tagcaatcat atgatagaaa gaacacattg gtgctcattt tcataaactt 2460
cattttgtta gattgtcact tagcaaagac tattgcggat tcttccttga gaactttcct 2520
ttcaattttc tgttgatttc cttaaaattt tcttcagggt cgagcaagtt ctgttgatat 2580
attgtgtcat gcaaagaaaa ctgtatttgt ggttagaaaa tgaagatttt agacctctta 2640
ttctgattta cttattaggc aagtcacttt acttcatgaa acctatttca ctgcatatga 2700
agtagaaata attataattt cctcataatg ttactgttag ctgaaataaa gtaaatgtga 2760
aatcaaaaaa aaaaaaaaaa a 2781
<210> 42
<211> 3863
<212> DNA
<213> Homo sapiens
<400> 42
atttaagagc caactgtctt gtctttcccg agtccgtttg aggaagtccc cgaggcgcac 60
agagcaagcc cacgcgaggg cacctctgga ggggagcgcc tgcaggacct tgtaaagtca 120
aaaatgtcag aaacttccag gaccgccttt ggaggcagaa gagcagttcc acccaataac 180
tctaatgcag cggaagatga cctgcccaca gtggagcttc agggcgtggt gccccggggc 240
gtcaacctgc aagagtttct taatgtcacg agcgttcacc tgttcaagga gagatgggac 300
actaacaagg tggaccacca cactgacaag tatgaaaaca acaagctgat tgtccgcaga 360
gggcagtctt tctatgtgca gattgacttc agtcgtccat atgaccccag aagggatctc 420
ttcagggtgg aatacgtcat tggtcgctac ccacaggaga acaagggaac ctacatccca 480
gtgcctatag tctcagagtt acaaagtgga aagtgggggg ccaagattgt catgagagag 540
gacaggtctg tgcggctgtc catccagtct tcccccaaat gtattgtggg gaaattccgc 600
atgtatgttg ctgtctggac tccctatggc gtacttcgaa ccagtcgaaa cccagaaaca 660
gacacgtaca ttctcttcaa tccttggtgt gaagatgatg ctgtgtatct ggacaatgag 720
aaagaaagag aagagtatgt cctgaatgac atcggggtaa ttttttatgg agaggtcaat 780
gacatcaaga ccagaagctg gagctatggt cagtttgaag atggcatcct ggacacttgc 840
ctgtatgtga tggacagagc acaaatggac ctctctggaa gagggaatcc catcaaagtc 900
agccgtgtgg ggtctgcaat ggtgaatgcc aaagatgacg aaggtgtcct cgttggatcc 960
tgggacaata tctatgccta tggcgtcccc ccatcggcct ggactggaag cgttgacatt 1020
ctattggaat accggagctc tgagaatcca gtccggtatg gccaatgctg ggtttttgct 1080
ggtgtcttta acacattttt acgatgcctt ggaataccag caagaattgt taccaattat 1140
ttctctgccc atgataatga tgccaatttg caaatggaca tcttcctgga agaagatggg 1200
aacgtgaatt ccaaactcac caaggattca gtgtggaact accactgctg gaatgaagca 1260
tggatgacaa ggcctgacct tcctgttgga tttggaggct ggcaagctgt ggacagcacc 1320
ccccaggaaa atagcgatgg catgtatcgg tgtggccccg cctcggttca agccatcaag 1380
cacggccatg tctgcttcca atttgatgca ccttttgttt ttgcagaggt caacagcgac 1440
ctcatttaca ttacagctaa gaaagatggc actcatgtgg tggaaaatgt ggatgccacc 1500
cacattggga aattaattgt gaccaaacaa attggaggag atggcatgat ggatattact 1560
gatacttaca aattccaaga aggtcaagaa gaagagagat tggccctaga aactgccctg 1620
atgtacggag ctaaaaagcc cctcaacaca gaaggtgtca tgaaatcaag gtccaacgtt 1680
gacatggact ttgaagtgga aaatgctgtg ctgggaaaag acttcaagct ctccatcacc 1740
ttccggaaca acagccacaa ccgttacacc atcacagctt atctctcagc caacatcacc 1800
ttctacaccg gggtcccgaa ggcagaattc aagaaggaga cgttcgacgt gacgctggag 1860
cccttgtcct tcaagaaaga ggcggtgctg atccaagccg gcgagtacat gggtcagctg 1920
ctggaacaag cgtccctgca cttctttgtc acagctcgca tcaatgagac cagggatgtt 1980
ctggccaagc aaaagtccac cgtgctaacc atccctgaga tcatcatcaa ggtccgtggc 2040
actcaggtag ttggttctga catgactgtg acagttgagt ttaccaatcc tttaaaagaa 2100
accctgcgaa atgtctgggt acacctggat ggtcctggag taacaagacc aatgaagaag 2160
atgttccgtg aaatccggcc caactccacc gtgcagtggg aagaagtgtg ccggccctgg 2220
gtctctgggc atcggaagct gatagccagc atgagcagtg actccctgag acatgtgtat 2280
ggcgagctgg acgtgcagat tcaaagacga ccttccatgt gaatgcacag gaagctgaga 2340
tgaaccctgg catttggcct cttgtagtct tggctaagga aattctaacg caaaaatagc 2400
tcttgctttg acttaggtgt gaagacccag acaggactgc agagggctcc agagtggaga 2460
tcccacatat ttcaaaaaca tgcttttcca aacccaggct attcggcaag gaagttagtt 2520
tttaatctct ccaccttcca aagagtgcta agcattagct ttaattaagc tctcatagct 2580
cataagagta acagtcatca tttatcatca caaatggcta catctccaaa tatcagtggg 2640
ctctcttacc agggagattt gctcaatacc tggcctcatt taaaacaaga cttcagattc 2700
cccactcagc cttttgggaa taatagcaca tgatttgggc tctagaattc cagtcccctt 2760
tctcggggtc aggttctacc ctccatgtga gaatattttt cccaggacta gagcacaaca 2820
taatttttat ttttggcaaa gccagaaaaa gatctttcat tttgcacctg cagccaagca 2880
aatgcctgcc aaattttaga tttaccttgt tagaagaggt ggccccatat taacaaattg 2940
catttgtggg aaacttaacc acctacaagg agataagaaa gcaggtgcaa cactcaagtc 3000
tattgaataa tgtagttttg tgatgcattt tatagaatgt gtcacactgt ggcctgatca 3060
gcaggagcca atatccctta ctttaaccct ttctgggatg caatactagg aagtaaagtg 3120
aagaatttat ctctttagtt agtgattata tttcacccat ctctcaggaa tcatctcctt 3180
tgcagaatga tgcaggttca ggtccccttt cagagatata ataagcccaa caagttgaag 3240
aagctggcgg atctagtgac cagatatata gaaggactgc agccactgat tctctcttgt 3300
ccttcacatc acccatgttg agacctcagc ttggcactca ggtgctgaag ggtaatatgg 3360
actcagcctt gcaaatagcc agtgctagtt ctgacccaac cacagaggat gctgacatca 3420
tttgtattat gttccaaggc tactacagag aaggctgcct gctatgtatt tgcaaggctg 3480
atttatggtc agaatttccc tctgatatgt ctagggtgtg atttaggtca gtagactgtg 3540
attcttagca aaaaatgaac agtgataagt atactggggg caaaatcaga atggaatgct 3600
ctggtctata taaccacatt tctaagcctt tgagactgtt cctgagcctt cagcactaac 3660
ctatgagggt gagctggtcc cctctatata tacatcatac ttaactttac taagtaatct 3720
cacagcattt gccaagtctc ccaatatcca attttaaaat gaaatgcatt ttgctagaca 3780
gttaaactgg cttaacttag tatattatta ttaattacaa tgtaatagaa gcttaaaata 3840
aagttaaact gattatattt gca 3863
<210> 43
<211> 2835
<212> DNA
<213> Homo sapiens
<400> 43
ctttcacttc cggcctggac ctgaggctcc tgctacgtgc agcggattgt gccgggcgtc 60
ggcaactgct cggctcgcca gactgttcac gggcccagta gagcagtaaa taaccggcca 120
cccctgcggc cgtgccggcc gtgatggaac tagacagctc acccgactcg agaagaacgg 180
ggtggggagg cgaggacgca gggcgacctg gagaagaaag tttcccagat ggctctaggg 240
tgaatcttga atgttgtgat gcagctcgcc aggcctacgg ggaggtaaag gacttgccag 300
gctgaagtaa cttcagaagc agaaaaacgg aggattaaaa ccacaagtcg ttgtgatgtg 360
aaatttcgtg gggcaagaaa gggccggaag taggtagtct gcacggctct gctagagaga 420
ggatcacaag atcacacaaa tgtgatctac ttatgactgg aaaaaatgtg tactttcaga 480
gccagcttga ggcattccat tgcctccaat atgagctctt cccttcaaga ttgactataa 540
atctcttagt tacaactcac atcccctttc cccagacaaa accccacata gcccggtgtg 600
tatttactga aagcagtaag atattgctgg ggctttgggt gcaagatgga gagtgctcag 660
agataatgac aggggcctgg tcctgcaggg ccttacgtag aaagtcaagg aatttattct 720
ctgagcaatt gaaaatcatc ccgaaagatc tgcattttag aaataccatg ttgagtagtt 780
gcataagaaa ccagttagga ggcccctttt tattggaggt agagaataat gagagactga 840
actacagaag tggggaagga agacagctgt agatccaaga aatagtatcc ggaagagagg 900
cttgagaagt gatcaaggag aattccacag ttatcagaga ccctgtcttc cttgttcacc 960
actatattac cagaacataa tacaaataat gctattgtta ttgggtggca ttatttggtt 1020
agtaggtact ttttaaaatt tttaaattta attttagtat taaaatacat gtaaagatca 1080
ggaaaatgaa cttttaaaaa taaagggctt tcactgggca tgataacaca tccctgtagt 1140
cccagctact cccagctatt caggaggctg aggcggcagg atcacttgaa ccaaggagtt 1200
caagtttagc ctgggcagta tagtgaaacc ctttctcaaa aacaaataaa gggctactga 1260
aataatgata atttatattc aggtcgtagg tacctaatta ctagttacac atacatggct 1320
ttgatgggaa atcaaagaaa cattctgaca atacagagat tcatcaagca atttgtcttt 1380
gaaagttgat tattcaaaaa cagagcttgt agcaaaagaa gcagaaatta gatcccacag 1440
tcatcaagtt tcagatccta aggcttgcat tcttacacca atttcttctt tgcttaaatc 1500
ttaattttca tcagcattaa ttaagtgtct gggtactctg ccagtcagga gagatgttac 1560
caaaggtaca ggatttgaga agtattgtca gaagagccaa gttcataatc aggcccacag 1620
gatcaataat ttgggggagt gtttagagca gtttcaaaga tgagagcagt agatcaaagt 1680
agaatttcag gactgagcac atgccaaggc acccttttat ggatattcaa cctgtaccag 1740
aagggaggag tcatttactt aaaagagtta cacaagatga aagagctaga tccaaataaa 1800
gacgctataa aaattactaa tggggctgag catggtggat tacagggatt cagttattta 1860
attattactg aaagagctct tttagactta accagatttt taaaccaaat attcttatgc 1920
atacataaaa gtaagttaca caagataaat ttgttgatct tccaaaatat ccccccttac 1980
tatacactag agtggggttt tggcataatg gcagacaaat agatggaacg gaatagaggg 2040
tccaggaaaa gagccatttg attattactc catttcaatg aagacaccaa tttaatttag 2100
tggggaaggc aagttatttt caataaaagg tgatgaagaa aatagatatc cctatgtggg 2160
aaaaatgaac tatgatcccc tacctcacag catacacaaa cttaattaaa aatggatcac 2220
aggctgggga tggtggctca cacctgcaat tccagcactg tggaaggcca agatgggagg 2280
atcacttgag cccaggagtt caagatcagc atgggtaata cgaggaaatc ccatctctct 2340
ttattttttt cttttttgag atgggggtgg ttaatgggta caaaaaaagt agcctgaata 2400
agacatacta ttcgagagca caatagggtg actatagtca ataataattg tatattttaa 2460
aagagtgtaa ctggattgtt tataactcaa aggataaatg attgagggta tggataaccc 2520
cattctccat gatgtgctta tttcacattg gatgcctata tcaaaacatc tcaggtaccc 2580
cataaatata tacacctact atataccaaa aaaacttaaa attaaaatta gactgggtat 2640
ggtagctcat gccttaatcc cagcactttg ggaggcaaaa aaaaaaaaaa aaaaaaaaaa 2700
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2760
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2820
aaaaaaaaaa aaaaa 2835
<210> 44
<211> 1529
<212> DNA
<213> Homo sapiens
<400> 44
agtgagcaat gcaattctgg gaatgttcag gctctctctg ttctttcctc tcttgcaaac 60
catgggcacc cttgggtccc ttggggtcac tatgttacac ctgcttttta tctgtctggg 120
caagagctgc tcaagccaca ccttgtgaca ctgagatcag ctatgaaaat acccagccgg 180
cctgcagccc tcccggcaga tgctgaaaag gaaacccgac tgggagatgc cgcccaccct 240
tatccccaga gagctgcgtt gtttcctctt gccttggcct ttggatccgg ccatagcaag 300
catccctggg cacctggctg aagctggaaa ctcgggataa gaatggaagc cctggaaggg 360
aagaagaacc gaggagtgag cttgccctga ggacagcaca ttgcactctc acctcctttg 420
cagttaagtg tgaaatagtg ccaatagagt gtaaaagaaa agaaagaaga tgattcacct 480
cccaaagatt ccccactgct gtgtcccttc tatcaacttg atacaaaaaa acacaatggc 540
cccgggaacc acgtgttgaa gatgagagag ctaaaagatg gaaagagact ggagccctga 600
gtcaccacct ggaggaaaac tacccaccca tcaggaattt ctactacaca tttgggagtt 660
tttggggtta cagcagctaa tttaacgaaa acacccagag acaagagcta ttactgcaca 720
aattggttaa gttacctttt tgtatgtttg ggtcctctct attcgatgag actgcgcgtt 780
cctttgaagc aaatctgttt aaaattctta tatccccaga gggcctagca gagagtatgc 840
acagagtgag ccttcagtaa atgctgagta aataagctcc taatggatga aactgtgtct 900
tcgaagtttg ttctgaccag tacttagtat aggattttgt gctgttggtc acttttcata 960
aaggttcttg ctattaagga acttgacatc caatgtactc atagaaagta gaaattcagg 1020
ggaaacaaat agaagagata tgtccaaaaa tccatttaaa atttcattga cagatattta 1080
tctctttaat cctggaagtt gtttcatgta agggaaggtt cagtagaatg aaaacaggac 1140
tgtaagctgg gaggagattt ggggtctctt ggccaactct gccacaaatt gtgttacctt 1200
caacttccct gcctgtaaaa tgaagtcagt ggtccctaaa atgaaattgg actaatggca 1260
aattagctag catttgatta tacatcgata gtttccccat gtgattttaa cgcacaaatc 1320
agattttgga accattaggt aggtgatctt atcttatgag tttatctttt tcaacatgga 1380
aaaataaatt tgttttgctg accgaaggct gtgtaactta gaactggaaa gagacatgta 1440
attgaataac ccatctctat ggggcaaaaa aatgaaacac ctttagtttg ttcaaagatg 1500
aaatggaaaa ataaacatgt tttaagatg 1529
<210> 45
<211> 1590
<212> DNA
<213> Homo sapiens
<400> 45
attagaaaac tgaagcttca agaacagact tgcctaacaa caggaaactt gtatgtctcg 60
aagtggcaat tcacacataa ggctccatga ctcctgaact ctcacaaata ttagttggct 120
cttttcatgg ttttactgaa gttgctagaa gtttacagaa aaggaagtgc aggaacattt 180
cacaaatcta caatctgtga gtatcacatc ctgtatagct gtaaacactg gaataaggaa 240
gggctgatga ctttcagaag atgaaggtaa gtagaaaccg ttgatgggac tgagaaacca 300
gagttaaaac ctctttggag cttctgagga ctcagctgga accaacgggc acagttggca 360
acaccatcat gacatcacaa cctgttccca atgagaccat catagtgctc ccatcaaatg 420
tcatcaactt ctcccaagca gagaaacccg aacccaccaa ccaggggcag gatagcctga 480
agaaacatct acacgcagaa atcaaagtta ttgggactat ccagatcttg tgtggcatga 540
tggtattgag cttggggatc attttggcat ctgcttcctt ctctccaaat tttacccaag 600
tgacttctac actgttgaac tctgcttacc cattcatagg accctttttt tttatcatct 660
ctggctctct atcaatcgcc acagagaaaa ggttaaccaa gcttttggtg catagcagcc 720
tggttggaag cattctgagt gctctgtctg ccctggtggg tttcattatc ctgtctgtca 780
aacaggccac cttaaatcct gcctcactgc agtggaactc tctctctgat gctgatttgc 840
actctgctgg aattctgcct agctgtgctc actgctgtgc tgcggtggaa acaggcttac 900
tctgacttcc ctgggagtgt acttttcctg cctcacagtt acattggtaa ttctggcatg 960
tcctcaaaaa tgactcatga ctgtggatat gaagaactat tgacttctta agaaaaaagg 1020
gagaaatatt aatcagaaag ttgattctta tgataatatg gaaaagttaa ccattataga 1080
aaagcaaagc ttgagtttcc taaatgtaag cttttaaagt aatgaacatt aaaaaaaacc 1140
attatttcac tgtcatttaa gatatgtgtt cattggggat ctcttgattt gcctgacatt 1200
gacttcagca aaagcacggg gctgtaaatt accatttact agattagcca aatagtctga 1260
atttccagaa aacaaggcag aatgatcatt cccagaaaca tttcccagaa aatgtttccc 1320
agaaaactag acagaatgat cattcaatgg atcacagtga agcaaaggac acaacttttt 1380
attgtacccc ttaattgtca acaggagtta actgatttgt tgtggtgctc agactttttt 1440
atacaggtgc tagtgtttta tcctatgtat tttaactcat tagtgcataa aggcaagccc 1500
catataatga agtctcaggg tatatgaaag tagctggctt caaaataaaa tttttgagtg 1560
caaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1590
<210> 46
<211> 2555
<212> DNA
<213> Homo sapiens
<400> 46
tgtttgcaaa taaaccattc tgataaatta tttttgttgc ttaaaataag aggaggaacc 60
gctgtgtgtt agcaagaatg tccatacctg atatgaaaga gtcatgttgg cttcagttcc 120
tactgccctg tggacttccc attccctcct tacttgagtc aaccatccac tcagtacttt 180
ccacaaatct aataatgagg tgctctctgt aggtaaatcc tttcactatg gcttgtcctc 240
aaacctccca agaaaaggtt caactgctca atctcttaac ctttttaatt ccattccctt 300
gcaggtatcc cggccctgca taacaagatg atcccaactc aaggaaaggg gtttagcagt 360
gttggatctt ggcgtatgtg ggatttaacc aggcagaaag gcagacaaga gtaagattct 420
aggcagagag agcaaatgcg tcgagcatgg gtatgaacat gtgagggata gagaataatt 480
ctgcaggaag tttgctggat ggaagggcct tatagggtta gaaaagctgg tgtcagattg 540
tcaaggactt tgaatgtcat ggggcttctc ttccaggaac acatgggatc aggcttagat 600
taacccaaat gtaattgtca gagcccagag atatttcatg gtccagtcct agcactgtgc 660
agctgccaaa agtcaaagcc attcaaatct gtactgaaaa ctgtggaaaa gcaaaggagc 720
acttaagtct ctttccccat gtcttgcatt ctcactctct tttgcttcaa agatctgtct 780
ttacctgccc ctgtccccag tcctaacaaa aagcactccc ctaaatcaac tcttaagttc 840
ctctcccttc tcactccttt cttagtctcc tctttctgta agaagttctt gctcctgttg 900
ttaatggaag ttaattaaag tagtatttca ccttgtaagg ctgtaattct tggcacttgt 960
tatcctcatt ttctacatcc aaagaccatg gaccagaata tctcttagga ggtaagggag 1020
agtgaggcta tcagccaaag aaaaagtctc cagggggaag gggagaatca cttataattt 1080
aatactttgt ggaaaaaaca tctctgccac ctatggccct ccaataacaa tggaagacag 1140
aatcaacagg tgagaacctt gggacaaaaa taagttacaa agctgttgta atccaggtaa 1200
gagctattaa gtttccaaac gaaggctgac tgtgaggata agtgatactg atttcagaaa 1260
tctttaaaaa gtagaaccaa caagccttga ggtctaactc tgttcaacat taaagggaag 1320
agtgagtcta agaagacttc aggtttctag cttggccaaa ccaattgagc tttaagtgaa 1380
atgtgcgata tggtaacaga gaaggaaaaa gacataacga tagatttgag ctgctggtgg 1440
gaaattctgg tttagtgccc agctggctgt acaggctggt tggactttag gagggaggtt 1500
tgagctggaa aataaagatg gagagttgtc tttcagtttt agatcatcag tgaggtcata 1560
agggtagatg gagtttacct gggaaaatta agtagctatt cgatttggct tattattatg 1620
ttaaaataat acttctctag tgaagtactt aatatgccag atactgtgcc aagcatttta 1680
tatacatcct ctcttttact aagccctcat agggcaggta ttttgattcc aatcatactg 1740
attggaactc ctaagaaggt atcttgctta aggtcccaca acgaataggt ggcagatcca 1800
gggtaattca ggtctgtcag aacagtgatt cttaattttt tccctcctca gactccagga 1860
gtcacatgaa gttatgcatc ctgtctgacc gaggcacagg cacaccacat ttttatattc 1920
cgcttccagg atatcacaaa cctgaagccc atcctccatg gcccagagag aaaacccagg 1980
acaaaacctt ggagaagact attttcatga agacaaatgg agaaggagca gtagagtaaa 2040
aagagagcaa atccagctgc ctgtacaatc catgccaccg aatgccgtaa gtgagacgta 2100
aaagttacga tactgaagag acgtaacctg accaaggcca cagagctgga aaaagaagca 2160
aagccaagcc gtttttctca tgcactgctc acaacaagcc cctccttcca ctgactcatg 2220
aaaaacacac tcataatgcc cagcccgcac cctaatgaac agccctctta agagtggtca 2280
tcagacttca atttcacaga ctagaattga gaaatggaac aaaaccttgg gataccagcc 2340
ttccattttg gtagggatca tttaaaaaat ggtagggatc atttaaaaaa tgtgttggtg 2400
tctgaaactt actttgaagt ggttaaaaaa cataaaatgt atagattgta acaagcaaat 2460
atgttaaaat gtactgtaca attctttctt tacaatttta tggatgttcg aaatttaaaa 2520
aatactagaa agagaatggt cttatttaaa aaaaa 2555
<210> 47
<211> 579
<212> DNA
<213> Homo sapiens
<400> 47
aggctcagta taaatagcag ccaccgctcc ctggcaggca gggacccgca gctcagctac 60
agcacagatc agcaccatga agcttctcac gggcctggtt ttctgctcct tggtcctggg 120
tgtcagcagc cgaagcttct tttcgttcct tggcgaggct tttgatgggg ctcgggacat 180
gtggagagcc tactctgaca tgagagaagc caattacatc ggctcagaca aatacttcca 240
tgctcggggg aactatgatg ctgccaaaag gggacctggg ggtgcctggg ctgcagaagt 300
gatcagcgat gccagagaga atatccagag attctttggc catggtgcgg aggactcgct 360
ggctgatcag gctgccaatg aatggggcag gagtggcaaa gaccccaatc acttccgacc 420
tgctggcctg cctgagaaat actgagcttc ctcttcactc tgctctcagg agatctggct 480
gtgaggccct cagggcaggg atacaaagcg gggagagggt acacaatggg tatctaataa 540
atacttaaga ggtggaattt gtggaaaaaa aaaaaaaaa 579
<210> 48
<211> 1307
<212> DNA
<213> Homo sapiens
<400> 48
acttatctgc agacttgtag gcagcaactc accctcactc agaggtcttc tggttctgga 60
aacaactcta gctcagcctt ctccaccatg agcctcagac ttgataccac cccttcctgt 120
aacagtgcga gaccacttca tgccttgcag gtgctgctgc ttctgtcatt gctgctgact 180
gctctggctt cctccaccaa aggacaaact aagagaaact tggcgaaagg caaagaggaa 240
agtctagaca gtgacttgta tgctgaactc cgctgcatgt gtataaagac aacctctgga 300
attcatccca aaaacatcca aagtttggaa gtgatcggga aaggaaccca ttgcaaccaa 360
gtcgaagtga tagccacact gaaggatggg aggaaaatct gcctggaccc agatgctccc 420
agaatcaaga aaattgtaca gaaaaaattg gcaggtgatg aatctgctga ttaatttgtt 480
ctgtttctgc caaacttctt taactcccag gaagggtaga attttgaaac cttgattttc 540
tagagttctc atttattcag gatacctatt cttactgtat taaaatttgg atatgtgttt 600
cattctgtct caaaaatcac attttattct gagaaggttg gttaaaagat ggcagaaaga 660
agatgaaaat aaataagcct ggtttcaacc ctctaattct tgcctaaaca ttggactgta 720
ctttgcattt ttttctttaa aaatttctat tctaacacaa cttggttgat ttttcctggt 780
ctactttatg gttattagac atactcatgg gtattattag atttcataat ggtcaatgat 840
aataggaatt acatggagcc caacagagaa tatttgctca atacattttt gttaatatat 900
ttaggaactt aatggagtct ctcagtgtct tagtcctagg atgtcttatt taaaatactc 960
cctgaaagtt tattctgatg tttattttag ccatcaaaca ctaaaataat aaattggtga 1020
atatgaatct tataaactgt ggttagctgg tttaaagtga atatatttgc cactagtaga 1080
acaaaaatag atgatgaaaa tgaattaaca tatctacata gttataattc tatcattaga 1140
atgagcctta taaataagta caatatagga cttcaacctt actagactcc taattctaaa 1200
ttctactttt ttcatcaaca gaactttcat tcatttttta aaccctaaaa cttataccca 1260
cactattctt acaaaaatat tcacatgaaa taaaaatttg ctattga 1307
<210> 49
<211> 3648
<212> DNA
<213> Homo sapiens
<400> 49
cccacgccta aggtccaggt cccagggctt tcccttgcac cttcatccct ggccctgcag 60
aggcctgctt ctcgcttccg gggtcgccag agcgcccctc ccgccacccc gccatctctt 120
ggccggatcg tgcgagagaa ggggaggagg tctggggttt ccagagtccg cggttttgct 180
aagaagccgc agtgatgttg acgcggctgg tcctcagtgc acacctgagt agcacgacct 240
ctccgccctg gacgcacgct gccatcagct gggagctgga caacgtgctg atgcctagtc 300
ccagaatctg gccccaggtg actccaacag gcaggtctgc ctctgtcagg agtgagggta 360
acacctcctc actctggaat ttctcagctg ggcaggatgt gcatgccata gtaaccagaa 420
cctgtgagtc tgtgctgagc tctgccgtct acacccacgg ctgtggctgt gtgaggtctg 480
ccacaaacat tacctgtcag tcctcaggac aacaaaggca ggcggcccgg caggaagagg 540
agaactcaat ctgcaaggcc catgatagta gagagggccg cctgggctac cccctcagtg 600
cccatcagcc tggttccggt ggtcctaact agccctgtct ccttgccaat agccctgtgc 660
tccccagccc cctcccccat gcagacggct gctatgacat ccctgttcct taaagtgcgg 720
ggttcctcgc tgccttctcc tccctaactg gcaccctgtg caaacctgct gcagagaaca 780
gtgtcttggg cagtgcgata gtcctccagt tcaccaacag taaaaatggt ctcaatgggg 840
agagatgtct gactgcaagc gctgagtcct tccagaggag ggctggaggg acaggagggc 900
ggatcaggtg gcctcctgag ctggttcctg gcgccgatgt aatggatgct gattaccagc 960
ggtgagggca tcgtggaagg gactgcagag gtgtgcgaga tgagtggaat gaggccccag 1020
gtgctgattt ttatgcccag gatgctcctg gctgtcatgg gctcccaggg gctccaggca 1080
tgcacagctc ttccgcctct tctcgaagca gaatgcccca gaaagggcac ctttactatc 1140
cagggtggct agagtcgccg gtggctgtgc gtgggggctg agggctagaa tcagggcaag 1200
gggctttcag tgaaacgcag agccaggcag ggacagcgcg gatctcagaa cagtctttgt 1260
cagatgggac acttcatccc cgcggagctg tccgtgcaca cagcgttctc tgattgccaa 1320
gctgttaagc actctgcgga agggagctgc tgggaaggcg gacgaggcat ctcaggtggg 1380
tgaggggctc cgctgcatca gcgttgctca gacccaccat ccctggggag ctgtcactga 1440
cgcccaggtt tccccttctc agtacatcct gtgcctcctt tctgggctgc ctcagtccct 1500
caaaggggag ctccccacat gggtgggatt attgttgaga acagtcaggg tgttgacgag 1560
gatgcaggac tgaggttgct cccagagtca ctcagtgtcc ctcgttttgc tcggagacat 1620
cctgacctgg gcaagctctt tagggagcat ctttcctgtc tgtgccgcat tctccatggc 1680
ctttgcactc tttttgcttt tgttttaaac acgtcatcaa ttcattgcct gcagcagctt 1740
gtactgcctt ttggtttttc tttgcagaac agctctggaa gtgaagtgtg tgtgtgtgtg 1800
tttgcgtgca ctactctgga ctgggtgcct tacacgtgtt aacacacttg atcagctcag 1860
caacactgtg gaataagtgt aatgtgtcca ttattcagat caggagactg agattcagag 1920
cagggaggga acttgccaga gaccacatgg cttgcaagca gcagaacctg ggtttgaact 1980
gacagcggcc tgacttcaga acccacgctt tcccaccctc ctacttcaca cccatttgag 2040
tccagccatc ttggttctga atcataaccc tgactctcct ggccacatcc tatgctccac 2100
attacatgtt actctacagg ttaccaccct gggtctcttt cctatataag aaatagaaat 2160
atttgtggaa atcctaatgt tcatgacatc tctgccattt tatcaggaaa aattctatcc 2220
taccaaatac tggtataatg tacttggccc ccctggattg gattggtata ggttaagagc 2280
agatataagg tctgaaataa tcccggtatt cctagtatgt ggaattatta tcatggaatc 2340
ataatggcag tttgcacctc tgttgggctc tttcaactcc tgtgttggct caggagaatc 2400
ctatcacatt agtccccttt tgtagttgga tagttgggct tgccagaagg cacacaaatt 2460
tgggttaact catttccagg attctggcat tgtagacaca gaaacaccga ctgtgaagtt 2520
ttatgtaata caaacactgg gagatttagc aataggcctg ccaggcggcc ctggcttctg 2580
gctgcacaac aaaggggggt ggctggtgct gaatggggca acagaaggtg agtttggggc 2640
ctgcagagcc tcgggtagcc cagaggagcg agagagtatt ggctgttcat tttaactcca 2700
tccttggagg attccccacc acaagcctaa ggaagtaata aaacctcatg cattattttt 2760
tgatatctgg agagaaacac gtaccctaga aatgctgtgg actaattcca tggttacttt 2820
gtcattaaag aaaccaaaat actgagaggt caccataaac acaaaaaggc agagagagaa 2880
ggattaaatg gtgtttcatg taaggatctt taaagggaga cagaattcta gtctgaaagg 2940
agcgcaggca gatctggcat tttgcttggg gagttcaatt ctttggagaa aatacagaga 3000
caaaaagacc attttgatgg tatttaaaat atccctctgc ccagtgtatc taagtgagtc 3060
taaatatatt cagcaatttt ttaaagggca gatattaggc ccgattcaag gtatggaata 3120
tagattcgaa agggttagtg ataggtgagt gcctttcagg tagctttgca tcacagacca 3180
agcccattat tgaggactgt acgtatggag caggcccgtg agcttgtgac tgagtttccc 3240
aacctgccag gctcccattt gcttaggatg aatatttttc tgccctccct ggtgagccac 3300
tgtgggccac tcgccactcc ttacacccct tccctttaat acctcgcttg gcttacttgc 3360
aaaatccaca tgcatcctcc tggatctcac agaagatgta tgaaaagtca tggccatgaa 3420
aagggcacgg aaatcaaatt aattaatttt gctttttccc cacgtttgtt tctgtctgtc 3480
tggtactttt cctttttaag cctgccatct ctttgaaagt gagccgcaca gtgataatcc 3540
attttcttca ttgtaacccc acagtgtatg tattccacat taaataataa aagggattaa 3600
taattaaatc aaaatgaaaa accaaaaaaa aaaaaaaaaa aaaaaaaa 3648
<210> 50
<211> 2232
<212> DNA
<213> Homo sapiens
<400> 50
agaaaggtcc aacagaccct ggaactgcag tctaaggtga tgaatgggtt tgtgggggga 60
agatgatagt cacagggagc tatgaaggag tctcacgtga gccaacagta tagattctga 120
aggcgtttat ggcaggagaa acaaaatacg cagggaaaga taatctcagt gttaaagaca 180
gatgtatgcc tggaggccaa gacagaaaat gagctgcaga gagaacgcag tagcctgcta 240
gccagccagt aaagaagtga ggctagttca gcggactcgc gcggcctcgc tctttggact 300
cgtcaccctc ccctccccct cccgccgccg tcacccagga aaccggccgc aaacgcgggc 360
ggacctgaag ctggtttcat ggcagcctca aagaaggcag ttttggggcc attggtgggg 420
gcagtggacc aaggcaccag ttccacgcgc tttttggttt tcaattcaag aacagctgaa 480
ctacttagtc atcatcaagt ggaaataaaa caagagttcc caagagaagg atgggtggaa 540
caggacccta aggaaattct acattctgtc tatgagtgta tagagaaaac atgtgagaaa 600
cttggacagc tcaatattgg tatttccaac ataaaagcta ttggtgtcag caaccagagg 660
gaaaccaccg tagtctggga caagataact ggagagcctc tctacaatgc tgtggtgtgg 720
cttgatctaa gaacacagtc taccgttgag agtcttagta aaagaattcc aggaaataat 780
aactttgtca agtccaagac aggccttcca cttagcactt acttcagtgc agtgaaactt 840
cgctggctcc tcgacaatgt gagaaaagtt caaaaggccg ttgaagaaaa acgagctctt 900
tttgggacta ttgattcatg gcttatttgg agtttgacag gaggcgtcaa tggaggtgtc 960
cactgtacag atgtaacaaa tgcaagtagg actatgcttt tcaacattca ttctttggaa 1020
tgggataaac aactctgtga attttttgga attccaatgg aaattcttcc acatgttcgg 1080
agttcttctg agatctatgg cctaatgaaa gcgggggcct tggaaggtgt gccaatatct 1140
gggtgtttag gggaccagtc tgctgcactg gtgggacaaa tgtgcttcca gattggacaa 1200
gccaaaaata cgtatggaac aggatgtttc ttactatgta atacaggcca taagtgtgta 1260
ttttctgatc atggccttct caccacagtg gcttacaaac ttggcagaga caaaccggta 1320
tattacgctt tggaaggttc tgtagctata gctggtgctg ttattcgctg gctaagagac 1380
aatcttggaa ttataaagac ctcagaagaa attgaaaaac ttgctaaaga agtaggtact 1440
tcttatggct gctacttcgt cccagcattt tcggggttat atgcacctta ttgggagccc 1500
agcgcaagag ggataatctg tggactcact caattcacga ataaatgcca tattgctttt 1560
gctgcattag aagctgtttg tttccaaact cgagagattt tggatgccat gaatcgagac 1620
tgtggaattc cactcagtca tttgcaggtt gatggaggaa tgaccagcaa caaaattctt 1680
atgcagctac aagcagacat tctgtatatt ccagtagtga agcccttgat gcccgaaacc 1740
actgcactgg gtgctgccat ggcggcaggg gctgcagaag gagtcgacgt atggagtctt 1800
gaacctgagg atttgtccgc cgtcacgatg gagcggtttg aacctcagat taatgctgag 1860
gaaagtgaaa ttcgttattc tacatggaag aaagctgtga tgaagtcaat gggttgggtt 1920
acaactcaat ctccagaagg tggtgaccct agtgtcttct gtagtctgcc cttgggcttt 1980
tttatagtga gtagcatggc aatgttaatc ggagcaaggt acatctcagg tattccataa 2040
aacctaccaa ctcatggatt cccaagatgc gagcttttta cataatgaaa gaacaaccca 2100
gcaattgtct cttaatgcga tgacactatt catagacttt gattttattt ataagccact 2160
tgctgcgtga ccctccaagt agacctgtgg cttaaaataa agaaaatgca gcaaaaagaa 2220
tgctatagaa at 2232
<210> 51
<211> 805
<212> DNA
<213> Homo sapiens
<400> 51
atgatgatcc tgcaggtttc agggggcccc tggacagtgg ctctgacagc attactgatg 60
gtgctgctca tatctgtggt ccagagcagg gccactccag agaattccgt ctaccaggaa 120
cggcaggaat gctatgcgtt caatgggact cagcgcgttg tggacgggct catctacaac 180
cgggaggaat acgtgcattt tgacagcgca gtgggggagt tcctagcagt gatggagctg 240
gggcggccca taggcgagta cttcaatagc cagaaggact ttatggaacg gaagcgagcc 300
gaggtggaca aggtgtgcag acacaagtac gagctgatgg agccactcat ccggcagcgc 360
cgagtccagc ctagggtgaa catctcccct ccaagaagga gccccagcag caccacgacc 420
tgcttgtcta ccacgtgaca gatttctacc cagacagcat tcaagtccga tgcttcctga 480
atggacagga ggaaacagct ggggtcgtgt ccaccaacct gatccgtaat ggagactgga 540
ccttccagat cctggagatg ctggaaatga ccccccagca gggaaacatc tacacctgcc 600
aagtggagca ccccagcctg gacagtcctg tcaccgtgga gtggaaggca cagtctgatt 660
ctgtgcagag caagatgctg acaggagcca ggggcttcat gctggggctc atcatctgtg 720
gagtggacat cttcacgcac agaaggagga agaaagttca acaaggatct gcataaacag 780
gcaatattcc tgctttgatt tcctt 805
<210> 52
<211> 2111
<212> DNA
<213> Homo sapiens
<400> 52
atgatgctca agtctatcac agaaagcttt gccacagcaa tccatggctt gaaagtggga 60
cacctgacag atcgtgttat tcagaggagc aagaggatga ttctagacac tctgggtgct 120
gggttcctgg gaaccactac ggaagtgttt cacatagcca gccaatatag caagatctac 180
agttccaaca tatccagcac tgtttggggt cagccagaca tcaggctccc gcccacatat 240
gctgcttttg tgaacggtgt ggctattcac tccatggatt ttgatgacac gtggcaccct 300
gccacccacc cttctggggc tgtccttcct gtcctcacag ctttagcaga agccctgcca 360
aggagtccaa agttttctgg ccttgacctg ctgctggctt tcaatgttgg tattgaagtg 420
caaggccgat tactgcattt cgccaaggag gccaatgaca tgccaaagag attccatccc 480
ccttccgtgg taggaacgtt gggtagtgct gctgctgcat ccaagttttt aggacttagc 540
tcgacaaagt gccgagaagc tctggccatt gctgtttccc atgctggggc acccatggcc 600
aatgctgcca cccagaccaa gcccctccac attggcaatg ctgccaagca tgggatagaa 660
gctgcatttt tggcaatgtt gggtctccaa ggaaacaagc aggtcttgga cttggaggca 720
ggatttgggg ccttttatgc caactattcc ccaaaagtcc ttccaagcat agcttcctac 780
agttggctgc tggaccagca ggacgtggcc tttaagcgtt ttcctgcaca tttatctacc 840
cactgggtgg cagacgcagc tgcatctgtg agaaagcacc ttgtagcaga gagagccctg 900
cttccaactg actacattaa gagaattgtg ctcaggatac caaatgtcca gtatgtaaac 960
aggccctttc cagtttcgga gcatgaagcc cgtcattcat tccagtatgt ggcctgtgcc 1020
atgctgcttg atggtggcat cactgtcccc tcattccatg aatgccagat caacaggcca 1080
caggtgagag agctgctcag taaggtggag ctggagtacc ctccggacaa cttgccaagc 1140
ttcaacatac tgtactgtga aataagtgtc accctcaagg atggagccac cttcacagat 1200
cgctctgata ccttctatgg gcactggaga aaaccactga gccaggagga cctagaggaa 1260
aagttcagag ccaatgcctc caagatgctg tcctgggaca cagtggaaag ccttataaag 1320
atagtcaaaa atctagaaga cctagaagac tgttctgtgt taactacact tctcaaagga 1380
ccctctccac cagaggtagc ttcaaactct ccagcatgta ataattctat cacaaatctc 1440
tcctgaggct taccaacatc taaatgactt tgcatttggg gagattcaat gatttggttt 1500
gtaaagcaag ggtctgctgc ttggttttcc caggaaaaat gaacaaagat ggagagagtc 1560
cagaaacaga actacatata tctggaagga gccttctcct gaaaattttg caggacagtt 1620
ccacttacct aaatcaagat gaaacacaca cacaaaaatg agtttgtaag cattcacaag 1680
ggtgaaattc aactcacctg tgatttactt ataaaattaa tctcttcata ggaattatgt 1740
gtggacttca tgagcctcaa ggttttagag ggatgtgaac ctgcatgtat attttctgac 1800
agtggagagg gctctggtgc attgtgtcac caacagatct cctagaccat ggcttattac 1860
caagccctcc acagtgcaag gggtgctact ggggaatggg tgggtttaaa tcctgcctct 1920
gccattcact agatgtagcc ttgagcatgt taccattagc cctctgcctc agtttcccta 1980
tttgtcaagc cgaagtaaaa agcagtctgg aaaaatcgca ttttggctct agaacccatg 2040
gtcttaagca ctgcaatata tcacctttca gtataaaaat atttgaatca gagttgcaat 2100
aaaaaaaaaa a 2111
<210> 53
<211> 5266
<212> DNA
<213> Homo sapiens
<400> 53
gcttaaaaat ttctgtgtct tacacagaag atagaaaaaa tagagtgtct ccaattggat 60
ggatttttta aaaaatttgg ttattgtaat ggatttattt tttcttagag ctgagctgat 120
tgtactttgg ccaactaatg ggttaatact gtcaagggaa attagccctg actaaacatt 180
gccgctggct catgaatgca ctaggcttgg ggcagtataa aaactcagag aaatcagtgt 240
gtaggagaca cagaaatcag tgtcactcag tgacagaagc aacaataatt gtgaaaaata 300
cttcagcagt tatggactca tctgtcattc aaaggaaaaa agtagctgtc attggtggtg 360
gcttggttgg ctcattacaa gcatgctttc ttgcaaagag gaatttccag attgatgtat 420
atgaagctag ggaagatact cgagtggcta ccttcacacg tggaagaagc attaacttag 480
ccctttctca tagaggacga caagccttga aagctgttgg cctggaagat cagattgtat 540
cccaaggtat tcccatgaga gcaagaatga tccactctct ttcaggaaaa aagtctgcaa 600
ttccctatgg gacaaagtct cagtatattc tttctgtaag cagagaaaat ctaaacaagg 660
atctattgac tgctgctgag aaatacccca atgtgaaaat gcactttaac cacaggctgt 720
tgaaatgtaa tccagaggaa ggaatgatca cagtgcttgg atctgacaaa gttcccaaag 780
atgtcacttg tgacctcatt gtaggatgtg atggagccta ttcaactgtc agatctcacc 840
tgatgaagaa acctcgcttt gattacagtc agcagtacat tcctcatggg tacatggagt 900
tgactattcc acctaagaac ggagattatg ccatggaacc taattatctg catatttggc 960
ctagaaatac ctttatgatg attgcacttc ctaacatgaa caaatcattc acatgtactt 1020
tgttcatgcc ctttgaagag tttgaaaaac ttctaaccag taatgatgtg gtagatttct 1080
tccagaaata ctttccggat gccatccctc taattggaga gaaactccta gtgcaagatt 1140
tcttcctgtt gcctgcccag cccatgatat ctgtaaagtg ctcttcattt cactttaaat 1200
ctcactgtgt actgctggga gatgcagctc atgctatagt gccgtttttt gggcaaggaa 1260
tgaatgcggg ctttgaagac tgcttggtat ttgatgagtt aatggataaa ttcagtaacg 1320
accttagttt gtgtcttcct gtgttctcaa gattgagaat cccagatgat cacgcgattt 1380
cagacctatc catgtacaat tacatagaga tgcgagcaca tgtcaactca agctggttca 1440
tttttcagaa gaacatggag agatttcttc atgcgattat gccatcgacc tttatccctc 1500
tctatacaat ggtcactttt tccagaataa gataccatga ggctgtgcag cgttggcatt 1560
ggcaaaaaaa ggtgataaac aaaggactct ttttcttggg atcactgata gccatcagca 1620
gtacctacct acttatacac tacatgtcac cacgatcttt cctccgcttg agaagaccat 1680
ggaactggat agctcacttc cggaatacaa catgtttccc cgcaaaggcc gtggactccc 1740
tagaacaaat ttccaatctc attagcaggt gatagaaagg ttttgtggta gcaaatgcat 1800
gatttctctg tgaccaaaat taagcatgaa aaaaatgttt ccattgccat atttgattca 1860
ctagtggaag atagtgttct gcttataatt aaactgaatg tagagtatct ctgtatgtta 1920
attgcaatta ctggttgggg ggtgcatttt aaaagatgaa acatgcagct tccctacatt 1980
acacacactc aggttgagtc attctaacta taaaagtgca atgactaaga tccttcactt 2040
ctctgaaagt aaggccctag atgcctcagg gaagacagta atcatgcctt ttctttaaaa 2100
gacacaatag gactcgcaac agcattgact caacacctag gactaaaaat cacaacttaa 2160
ctagcatgtt aactgcactt ttcattacgt gaatggaact tacctaacca cagggctcag 2220
acttactaga taaaaccaga aatggaaata aggaattcag gggagttcca gagacttaca 2280
aaatgaactc attttatttt cccaccttca aatataagta ttatcatcta tctgtttatc 2340
gtctatctat ctatcatcta tctatctatc tatcatctat ctatctatct atctatctat 2400
ctatctatct atctatctct atttatttat gtatttagag atcaggtctc actctgttga 2460
ccaggctgga gtgcagtggt gagatctggg ttcactgcaa cctctgcctc ctgggctcaa 2520
gcaatcctcc cacttcagcc tcccaaatag ctggggctac catggtattt ttcagtagag 2580
accgggtctt gccatgctgc ccaggccagt ctcaaactcc tggcctcatg tgatctgccc 2640
acctcagcct cccaaagtac agggattaga gttgtgagcc accgctgcca gcccagagtt 2700
accctctaaa gataagaaaa aggctattaa tatcatacta agtgaaggac aggaaagggt 2760
tttattcata aattaaatgt ctacatgtgc cagaatggaa aggaaacaag gggagacaac 2820
ttttatagaa atacaaagcc attactttat tcaatttcag accctcagaa gcaatttact 2880
aatttattct tcgactacat actgcagcag aaccagcaat acacttgatt tttaaaagca 2940
catttagtga aatgttttct ttggttcatc cttctttaac aggctgctga gtcactcaga 3000
aatccttcaa acatgattaa ttatgaagat gaaacactag agtcatataa gaaataaaaa 3060
ttgggcaata aaataaaatg attcagtgtt tcttttctat attgtcaatg aaaaccttga 3120
gttctaataa tccatgttca gtttgtaggg aaagaaaaaa taatttttcc ttctacccac 3180
tttaggttcc ttggctgggg cccctataac aaaagacaga ttgacaagag aaaaacaaac 3240
ataaatttat tagcgggtat atgtaatata tatgtgggaa atacagggga atgagcaaat 3300
ctcaaagagc tggcgtctta gaactccctg gcttatatag catcgacaaa gaacagtaaa 3360
tttttagaga aacaacaaaa caaagaaaaa gagctttgag tctgtagggg cagcaatttg 3420
ggggaagcaa atatatggga gtttgccttg tagattcctc tggtgctggt ctccaggctg 3480
acaaggattc aaagttgtct ctgaaactcc tctttgtcat actgcacata taaaacgtct 3540
tttgtttcca acaagaggat tttctttttc attctagaat tatctccttg ataacttgat 3600
cagatatagg acatgacact gaatagagtc caacagtaca aaaaaaattc agtatgttct 3660
agctacttca cacatgtgta cgcgacagtt atttttacag taaggtattt tcgagaaaaa 3720
tgcattacgt gttttggaaa atagagtaat ttaaaaaata tatttgaaat gaaaatctcc 3780
aacacattag aagatgatga tgttagatgc ccatcgtgtg ccacaagtgg ttttttcatt 3840
atgtaaagca cccgttgaat taaaagaatt tgtttttgtt caacctcttc ctgaggccca 3900
agagcatatg ggcaattcgg atttcctgct ggaccacaag gttctgttga tattacatag 3960
aacgggtatt ccagacactt cttatgatga aagtccaaaa gtggcatcca atttaaggcc 4020
ccatctttcg ttgccattct tcattcctac aaaggacgaa cttggattac atcaactttg 4080
gacccattgg ttttgtcgct gtcgtcaact gacagtgatt catcactggt gatgataaaa 4140
atgatggaag aagagttgaa agtcactttt ttctttggcc tgtccccatc tttctgtgac 4200
atcacaatgg gtctgatctg catttcactt ccagctgctg gtaggtcttt agcaggcctc 4260
tggcacctca gcagtcggag gcacagaagc tgcaaaaggg atcttcgaaa ctgggcagag 4320
aaaaaataaa gtggaatatt aagtaaaagt tgggcactaa tctggattaa cattcgagga 4380
aatcagttga gctgaattta agttgttttt tgtttgttag caggtgtgga tgtggggtta 4440
tgtggtcatg ctcagatcta cctaaatcac cccagagctt tatgtctttt attcattcta 4500
attcttatta accggaatat gtaggaccat ttcaatacct tgtaatcctc caagcttcaa 4560
tctgcacaca ctttctatga gggcaggtac aactattaag agattttgaa cattaagtta 4620
gtccacaaat attcagtggg catctactag gtgacagcca ctgtgctata attagagact 4680
ttttactata agcatcaaaa acagataagg ctcttcctgg cagagtttac agcctggtgt 4740
acttgctaat gtctctttaa ttaggtgaag aatttttttt ttctatcgaa attactaatc 4800
agttggggaa aaaaatacta tagcagacag cactaatgtc atcaacaaac attgttcttc 4860
tccgtgtcct gggtacaaca tcgaataata tttcttggcc tcctttccgc ttctcctctc 4920
tgctgttcct ctctacaaga acctgggagg ccaacgccta aagatcataa tatcacacaa 4980
tggaaggaac ctagattcct aaatgactgc ataggacaga tcccatctcc tccacccaat 5040
acattattag actgaactgt gacctgaaat gagcaataaa ctctgtatta attcactgaa 5100
atgttggggt tgcttgttat agtagtcggt ccatcatgac cagtaaaaca taaatcaaaa 5160
gttaatgtaa ttgttatccc attatttaga gcgaaataaa tgttgaatat atggactttc 5220
tcagattagg aaataccaat taaaaatata ataaatagct acattg 5266
<210> 54
<211> 2818
<212> DNA
<213> Homo sapiens
<400> 54
attctgcctt gtcccataga tttagaaaga ggctgacaca tctggtaact agtttacggt 60
catctgcctc taagcgacat ttagggtaag cgacattttt cagaaaccaa ggccctccct 120
ctcgtctcac tagtgggaag ggtggaaaga acaggacaga aagctcttcc tcttgtgtga 180
ggcagttgct gtggaagccc cataggcagg aggcccccgg gcagcacatc ctgtctgctt 240
gtgtctgctg cagagttctg tccttgcatt ggtgcgcctc aggccaggct gcactgctgg 300
gacctgggcc atgtctcccc accccaccgc cctcctgggc ctagtgctct gcctggccca 360
gaccatccac acgcaggagg aagatctgcc cagaccctcc atctcggctg agccaggcac 420
cgtgatcccc ctggggagcc atgtgacttt cgtgtgccgg ggcccggttg gggttcaaac 480
attccgcctg gagagggaca gtagatccac atacaatgat actgaagatg tgtctcaagc 540
tagtccatct gagtcagagg ccagattccg cattgactca gtaagagaag gaaatgccgg 600
gctttatcgc tgcatctatt ataagccccc taaatggtct gagcagagtg actacctgga 660
gctgctggtg aaagaaagct ctggaggccc ggactccccg gacacagagc ccggctcctc 720
agctggaccc acgcagaggc cgtcggacaa cagtcacaat gagcatgcac ctgcttccca 780
aggcctgaaa gctgagcatc tgtatattct catcggggtc tcagtggtct tcctcttctg 840
tctcctcctc ctggtcctct tctgcctcca tcgccagaat cagataaagc aggggccccc 900
cagaagcaag gacgaggagc agaagccaca gcagaggcct gacctggctg ttgatgttct 960
agagaggaca gcagacaagg ccacagtcaa tggacttcct gagaaggaca gagagacgga 1020
cacctcggcc ctggctgcag ggagttccca ggaggtgacg tatgctcagc tggaccactg 1080
ggccctcaca cagaggacag cccgggctgt gtccccacag tccacaaagc ccatggccga 1140
gtccatcacg tatgcagccg ttgccagaca ctgaccccat acccacctgg cctctgcacc 1200
tgagggtaga aagtcactct aggaaaagcc tgaagcagcc atttggaagg cttcctgttg 1260
gattcctctt catctagaaa gccagccagg cagctgtcct ggagacaaga gctggagact 1320
ggaggtttct aaccagcatc cagaaggttc gttagccagg tggtcccttc tacaatcgag 1380
cagctccttg gacagactgt ttctcagtta tttccagaga cccagctaca gttccctggc 1440
tgtttctaga gacccagctt tattcacctg actgtttcca gagacccagc taaagtcacc 1500
tgcctgttct aaaggcccag ctacagccaa tcagccgatt tcctgagcag tgatgccacc 1560
tccaagcttg tcctaggtgt ctgctgtgaa cctccagtga ccccagagac tttgctgtaa 1620
ttatctgccc tgctgaccct aaagaccttc ctagaagtca agagctagcc ttgagactgt 1680
gctatacaca cacagctgag agccaagccc agttctctgg gttgtgcttt actccacgca 1740
tcaataaata attttgaagg cctcacatct ggcagcccca ggcctggtcc tgggtgcata 1800
ggtctctcgg acccactctc tgccttcaca gttgttcaaa gctgagtgag ggaaacagga 1860
cttacgaaaa cgtgtcagcg ttttcttttt aaaatttaat tgatcaggat tgtacgtatt 1920
caaggtgtaa aatgtgataa tttgtcgtac acgtacattg tgcaatgaca gtcacaatca 1980
attcctcagc gcacccatcg ccacagatac gatacattag atattctgaa cttgctcatc 2040
ttaggacttc acattggtgt cagtgttttc tgacaaatca cgtgtatcag gaatgaatga 2100
gggaggtgtg gctgggtgaa ggcagagagc cgaccctaca ggtccacatc tgcacataca 2160
tgcacaggaa tgcatgctct cacacacatg catacacaca cgcacacaca cagacatgca 2220
catacactca cacgccccag gaaatccaag gaatcactga gcctgctgtt ggttgaggca 2280
tttctgagta tccaccctac ctgtagggtc agatgtactg attgacacag aaaattaccc 2340
tatgtaccac taggaggcgg cagaatctca tttgggttaa tctgtgtttg tctttaaaaa 2400
acaaaaacag gccgggcatg gaggctcacg cctgtaatcc cagcactttg ggaggctgag 2460
gtgggcggat cacgaggtca ggagatcgag accatcctgg ctaacacggt gaaaccccat 2520
ctctactaaa aatacaaaaa aattagccgg gtgtggtggt gggtgcctgt agtcccagct 2580
actcgggagg ctgagggagg agaatggcgt gaacccggga ggcggagttt gcagtgagcc 2640
gaggtggtgc cactgcactc cagcctgggc gacagagcga gactccgtca aaaaagaaaa 2700
gaaaagaaaa gaaagatttt taagaattca gcaaaaactc agccagctct ttctatgggg 2760
cagttgctaa tttagttcta ggcaaacgtg gacacattaa attctcctac aaaccctc 2818
<210> 55
<211> 3624
<212> DNA
<213> Homo sapiens
<400> 55
aatgtctcag gaacctacga catactccct tttcctattc ctttttctga gccatggagt 60
gtcgagttat acagtgccaa attccaggca ggatttgcat ccattgttgc aaaacatggc 120
ggaagaaata atagatggaa gctatctgaa tgcactgctg gatctcatac agtttcaaag 180
ctcccacgtg tggacggatg acctgtccca cagagtcctg gcctatctga attcccggaa 240
tgttgccttc accatcccca gcctgcaggc agccgtggaa aaccacctgg agcagcgtct 300
gcaccagccc cagaagctgc tggaggacct gaggaagaca gacgcccagc agttccgcac 360
tgccatgaaa tgcctcttag aagacaagaa ggacggcttg gacctgaaag acatcatcat 420
cgacttagga gagattcgag aacgagcctt gcagagccct ggcgtgaacc gcagcctgtt 480
tctcatcaca ctggagaggt gtttccagat gctgaactcc ctggagtgtg tggagatcct 540
gggcaaggtg ctgagggggt cctcagggag ctttctccag ccagacatca cagagcggct 600
ccctcgggac ctgcgcgagg atgcctttaa gaacctatct gcagtgttca aagatctcta 660
cgacaaaacc tcggctcatt cccagagagc tctctattcc tggatgactg gaatactgca 720
gacatcctcc aatgccactg atgactctgc ttcatgggtc agtgcggaac acttatgggt 780
tttgggcaga tacatggttc acctatcgtt tgaagaaatt acgaaaatta gtcctataga 840
aattgggctg tttatcagct atgacaacgc caccaagcag ctggacatgg tctatgacat 900
cacacctgag ctggcccagg cgtttctgga gaggatcagc tcctccaact ttaacatgag 960
gaatacctcc accatccaca ggctggggct gctggtttgt ttctacaatg acctggaatt 1020
gctggatgcc actgtggctc aagtcctgct ttaccagatg atcaagtgca gccacctgag 1080
gggcttccag gctggcgtcc agaagctcaa agcagaactc ctggacattg ccatggagaa 1140
ccagaccctc aatgagaccc tgggttcttt gtcggatgca gttgtaggtt tgacctacag 1200
ccaactggaa tccctctccc ccgaggctgt gcacggagcc atctccaccc tcaaccaggt 1260
ctcaggttgg gccaagagcc aggtcatcat cttgtctgcc aaatacttgg cccatgagaa 1320
ggtgctgtct ttctacaatg tcagccagat gggcgcactg ctggctgggg tcagcaccca 1380
ggccttctgc agcatgaaac gcaaggacat ctcgcaggtc ctgagaagtg ccgtctccca 1440
gtatgtatcc gacttgtcac ctgcccagca gcaaggtatc ctcagcaaga tggtccaagc 1500
ggaagacact gccccaggca tcgtggagat acaaggggct ttctttaagg aagtgtctct 1560
ctttgattta aggaggcaac ctggattcaa ctctacagtc ctgaaggata aggaacttgg 1620
aaggagccag gctctgttcc tgtatgagct tctgttaaag accaccagaa ggcctgagga 1680
gcttttgagt gctgggcagc tggtcaaagg cgtgacctgc tcacacattg atgccatgag 1740
cactgacttc tttctggccc atttccagga ttttcagaac aacttcgccc tgctttcacc 1800
ctatcaggtt aattgtttgg cgtggaaata ctgggaagtt tccagattgt ctatgccacc 1860
tttcctcttg gctgcactcc cggcccgcta cctggcttct gtcccagcct cccagtgtgt 1920
gccctttctg atcagcctgg ggaagagctg gttggactcc ttggttttag attcccacaa 1980
aaagacttca gtcctcagga aagtgcagca gtgcctggac gactccattg ctgatgagta 2040
cactgtggac atcatgggga acctgctgtg tcacttgccg gcagccatca tcgacagggg 2100
gatctccccc agggcttggg cgactgctct acacggcctc agagactgcc cagacctcaa 2160
ccctgagcaa aaggctgcag tgaggctcaa gctcctggga cagtatggac tccctcagca 2220
ctggacagcc gagaccacga aggacttggg accctttcta gtacttttct caggagatga 2280
attaagctct atagccacaa agtttcctga gatccttctg caagcagctt ccaagatggc 2340
caggaccctg cccactaaag aattcctctg ggctgtcttt cagtctgttc ggaacagcag 2400
tgataagatc cccagctatg accctatgcc tggttgccat ggagtcgtgg ccccctcttc 2460
tgatgacatc ttcaagttgg ccgaagccaa cgcctgctgg gccctggagg acctgcggtg 2520
catggaggaa gacacattca tcaggaccgt ggaactgctg ggagctgtcc agggtttcag 2580
ccggcctcag ctgatgaccc tgaaggagaa agcaatacag gtttgggaca tgccatctta 2640
ctggagagaa caccatatcg tctccctggg gcgcattgct ctggctctta atgagagtga 2700
gctggagcag ctggacctca gctccataga cactgtggct tccctaagct ggcaaacaga 2760
atggaccccg ggacaggctg aatccatttt gcaagggtac ctggatgatt caggatacag 2820
tatccaggac ctgaagagct ttcatttggt aggacttggt gcaaccctgt gtgctataaa 2880
catcactgaa atcccactta taaagatctc agaattcagg gtggtagtgg ccagaattgg 2940
gaccctgctc tgcagcacac atgtcttagc cgagtttaag aggaaggctg aagttgtgtt 3000
tggggatccc actgagtgga ccagttctgt cttgcaggag cttgggacca ttgcagctgg 3060
attaactaag gcagagctcc ggatgcttga caaggatttg atgccatatt tccagccatc 3120
agcaataaaa tgccttcctg atgagatatt caaagagctg tccgcggagc agatcgcctc 3180
cctgggtccg gagaacgccg cggcggtgac ccacgcccag cgccggcggc tcagtccact 3240
gcagctgcag agcctccagc aggcgctaga tggcgccaag actcactcct ggcaggacgc 3300
gcccgctagc gccggtccca ctagaacctc atcctcgcgt tctcccgcag gagctctcca 3360
gtcgtggggt ctttggcttg gttgtcccct gctggttcta atggccaagc tcctgtggtg 3420
agtggcctga gcgcatcgtc ctgtgttgcc ccaagcagct ggccaacatg tgtagagaca 3480
ggatgctcca gatggtggga cacccttccc tggatccaga ccctcatcta gggcagggaa 3540
accctggggc cttgatggtg aaaatgcacc ccaaatgaaa aataattatt aaaaatgatc 3600
ttgcaaatta aaaaaaaaaa aaaa 3624
<210> 56
<211> 6831
<212> DNA
<213> Homo sapiens
<400> 56
ccaggcccca ttgttcccgg tttccagcca tggctgccat tacctgacca gcgccacagc 60
cggtctctct gcaggcgccg ggagaagtga ccagagcaat ttctgctttt cacagggcgg 120
gtttctcaac ggtgacttgt gggcagtgcc ttctgctgag cgagtcatgg cccgaaggca 180
gaactaactg tgcctgcagt cttcactctc aggatgcagc cgaggtgggc ccaaggggcc 240
acgatgtggc ttggagtcct gctgaccctt ctgctctgtt caagccttga gggtcaagaa 300
aactctttca caatcaacag tgttgacatg aagagcctgc cggactggac ggtgcaaaat 360
gggaagaacc tgaccctgca gtgcttcgcg gatgtcagca ccacctctca cgtcaagcct 420
cagcaccaga tgctgttcta taaggatgac gtgctgtttt acaacatctc ctccatgaag 480
agcacagaga gttattttat tcctgaagtc cggatctatg actcagggac atataaatgt 540
actgtgattg tgaacaacaa agagaaaacc actgcagagt accaggtgtt ggtggaagga 600
gtgcccagtc ccagggtgac actggacaag aaagaggcca tccaaggtgg gatcgtgagg 660
gtcaactgtt ctgtcccaga ggaaaaggcc ccaatacact tcacaattga aaaacttgaa 720
ctaaatgaaa aaatggtcaa gctgaaaaga gagaagaatt ctcgagacca gaattttgtg 780
atactggaat tccccgttga ggaacaggac cgcgttttat ccttccgatg tcaagctagg 840
atcatttctg ggatccatat gcagacctca gaatctacca agagtgaact ggtcaccgtg 900
acggaatcct tctctacacc caagttccac atcagcccca ccggaatgat catggaagga 960
gctcagctcc acattaagtg caccattcaa gtgactcacc tggcccagga gtttccagaa 1020
atcataattc agaaggacaa ggcgattgtg gcccacaaca gacatggcaa caaggctgtg 1080
tactcagtca tggccatggt ggagcacagt ggcaactaca cgtgcaaagt ggagtccagc 1140
cgcatatcca aggtcagcag catcgtggtc aacataacag aactattttc caagcccgaa 1200
ctggaatctt ccttcacaca tctggaccaa ggtgaaagac tgaacctgtc ctgctccatc 1260
ccaggagcac ctccagccaa cttcaccatc cagaaggaag atacgattgt gtcacagact 1320
caagatttca ccaagatagc ctcaaagtcg gacagtggga cgtatatctg cactgcaggt 1380
attgacaaag tggtcaagaa aagcaacaca gtccagatag tcgtatgtga aatgctctcc 1440
cagcccagga tttcttatga tgcccagttt gaggtcataa aaggacagac catcgaagtc 1500
cgttgcgaat cgatcagtgg aactttgcct atttcttacc aacttttaaa aacaagtaaa 1560
gttttggaga atagtaccaa gaactcaaat gatcctgcgg tattcaaaga caaccccact 1620
gaagacgtcg aataccagtg tgttgcagat aattgccatt cccatgccaa aatgttaagt 1680
gaggttctga gggtgaaggt gatagccccg gtggatgagg tccagatttc tatcctgtca 1740
agtaaggtgg tggagtctgg agaggacatt gtgctgcaat gtgctgtgaa tgaaggatct 1800
ggtcccatca cctataagtt ttacagagaa aaagagggca aacccttcta tcaaatgacc 1860
tcaaatgcca cccaggcatt ttggaccaag cagaaggcta gcaaggaaca ggagggagag 1920
tattactgca cagccttcaa cagagccaac cacgcctcca gtgtccccag aagcaaaata 1980
ctgacagtca gagtcattct tgccccatgg aagaaaggac ttattgcagt ggttatcatc 2040
ggagtgatca ttgctctctt gatcattgcg gccaaatgtt attttctgag gaaagccaag 2100
gccaagcaga tgccagtgga aatgtccagg ccagcagtac cacttctgaa ctccaacaac 2160
gagaaaatgt cagatcccaa tatggaagct aacagtcatt acggtcacaa tgacgatgtc 2220
agaaaccatg caatgaaacc aataaatgat aataaagagc ctctgaactc agacgtgcag 2280
tacacggaag ttcaagtgtc ctcagctgag tctcacaaag atctaggaaa gaaggacaca 2340
gagacagtgt acagtgaagt ccggaaagct gtccctgatg ccgtggaaag cagatactct 2400
agaacggaag gctcccttga tggaacttag acagcaaggc cagatgcaca tccctggaag 2460
gacatccatg ttccgagaag aacagataat ccctgtattt caagacctct gtgcacttat 2520
ttatgaacct gccctgctcc cacagaacac agcaattcct caggctaagc tgccggttct 2580
taaatccatc ctgctaagtt aatgttgggt agaaagagat acagaggggc tgttgaattt 2640
cccacatacc ctccttccac caagttggaa catccttgga aattggaaga gcacaagagg 2700
agatccaggg caaggccatt gggatattct gaaacttgaa tattttgttt tgtgcagaga 2760
taaagacctt ttccatgcac cctcatacac agaaaccaat tttctttttt atactcaatc 2820
atttctagcg catggcctgg ttagaggctg gttttttctc ttttcctttg gtccttcaaa 2880
ggcttgtagt tttggctagt ccttgttctt tggaaataca cagtgctgac cagacagcct 2940
ccccctgtcc cctctatgac ctcgccctcc acaaatggga aaaccagact acttgggagc 3000
accgcctgtg aaataccaac ctgaagacac cgttcattca ggcaacgcac aaaacagaaa 3060
atgaaggtgg aacaagcaca gatgttcttc aactgttttt gtctacactc tttctctttt 3120
cctctaccat gctgaaggct gaaagacagg aagatggtgc catcagcaaa tattattctt 3180
aattgaaaac ttgaaatgtg tatgtttctt actaattttt aaaaatgtat tccttgccag 3240
ggcaggcaag gtggctcacg cctgtaatcc cagcacttca ggaggctgag gtgggcggat 3300
cacctgaggt caggagtttg agaccagcct gatgaaaccc tgtctctact aaaaatacaa 3360
gaattagccg ggcgtggtgg cgcatgcctg tagtatcagc tactcaagag gctgaggtga 3420
gattatcgct tgaacccagg aaacggaggt tgtagtgagc ggagatcgcg ccactgcact 3480
ccagcctgag tgacagagtg agaatccatc tcaaaaaaaa caaaaaacaa aattgcttgc 3540
taaagaagtg gtctcctgag gtcttaagac attcctgaca gtgtcttgag tgggtgggag 3600
agaggctgct gtcattgcgc tgtggaattt cacagatgag aaccacgcct agccaaaatc 3660
acttttcctg tttgcctcag tgacacagct gcagggaccc tcgtggatgt tgtattaaat 3720
aaatttgacc tttgctcttt gcagatctgt gaaatgttgt cttctgaggg gccacatgca 3780
tctatagtgc tgaggactcc ttgggcctct gaagtcacag agagaaccga gcaggtctat 3840
gtttttgttt tgttgttttg agacggagat tcgctcttgt tgcccgggct ggactgcagc 3900
ggcgcaacct ctgctcactg caacctccgc ctcctgggtt caagcagttc tcctgtctca 3960
gcctcccgag tagctgggat tacaggcaca tgtcaccacg cctggctaat ttttgtattt 4020
ttagtagaga tggggtttca ccacgttggc caggctgatc tcgaatgcct gacctttggt 4080
gatctgcccg ccttgtcctc atgtgtgctc cacaggcctt tgggttggga ttgcaggcgt 4140
gagccaccat gcccagccta gactcttttg acaatatgat gaaagctgtt ggttcctttc 4200
cccaacacac acacaccgag ttgtatcacg aaaatgtcat acaatttcca ggttttctga 4260
gtggtgggct cagattgagg tcaaaggatc agacgacctc taacgacctt catgtctctg 4320
ttgatgatct ggggacagcc agatcccctg tgtccaggga gttccttagt cccttgccac 4380
caccagagaa gggcaattgc cacgggagct gcaaagaccc tattcctact cctggtgcct 4440
tacttatgca gcacgactga attttttgtt ttgttttgtt ttgttgagac aggggcttgc 4500
tctgttgccc aggctggagt gcagtggcac aacaatggct caccgcagcc tcgaacccct 4560
gggctcaagc gatcctccca tctcagcttc ctgggtagct gggaccagag gcgtgagccg 4620
ccatagctgg ctaattttta attttttttt tgcagagatg aggtttcacc atggtgccca 4680
ggctggtctc gaacttctgg gctcaagtga tcctccctcc ttggcctcgc aaagtgctgg 4740
gattgcaggc atgagccacc gcccccggcc tgtggagcac acatgagttt aaaattactt 4800
tcccttctgc ctatatttcc gaggaggaaa cttcatgcgc agggatcttt cttagtggat 4860
ttaatggcta aaaggtctgt ctgaatccag gacgctggct ttagccttcc tcggcagctg 4920
ccgtaacccc ggtgtctaaa cctgaagcat cccaggagca cccactccag gagttttctc 4980
ggccgcggaa ctcattagtt agagcgccct cttgtgttct catgtggtaa tcggtcactg 5040
aaggacttaa aatggtcctt agccaacaca cagtaaaact tttccctctt ctgaccccaa 5100
gaggtcagcc acccatttca tgagcatata ctggtcgccc catcagcgtt ctctgattgg 5160
ctaactgaac ccactccccg acctagactc aagacaggcg aagtgacgct taggtcaaca 5220
ttcactcact aaagcaacga ctgtcgggcg attttgtctc ccgctggttt tggaatggtg 5280
tctggagaca tttttggttg tcacagctgg gtgggtgtgc tcccggcatc tggtgggtag 5340
aaaccaagca tgctcctaaa catcctacag gcacagaacc gtctcccacg accaagcatg 5400
atcaagtccc aaatgccaat aatggccagg ttgagaaact ctgcacagaa gcatccagtt 5460
atttgtctgt ttgctcaaca agcttgtgct catcatgctc tgtgttcctg acgctgtgct 5520
gggtgttggc ggtgggaaga ttacaagagt cacatggcag ctgtcctcct ggaaggtaca 5580
acccagtaga gatgcagact aacagagagc caattacaaa gcagtgtgac aagcgtcatg 5640
gtggaaaatt aaaagctcaa acaagggcac atgggagggg cttccaacac agactttggg 5700
ggatccagga aggtctaaga ggaaagtggg tctcaccaaa gccttgacca taggcagagg 5760
gtaccagtgg aaaaggtggg gtgaagaaca ttgaggacaa aaggaagaag tgcaggaagg 5820
ccctgaggca agggagtggg gggtgccctg gagggatggc agcagggcag tctgtcagac 5880
ccaagtggcc tccagcccta gaagccaatt agtcctcctc aaaaagctgt cactgtcccc 5940
taagaattgc tgccaggctc ccactggcct gactcagtct ttgagagtct taaggaggag 6000
gtctctgaaa ggtacacacc aagaactctc cccagcacag ctgtttttaa gactctccac 6060
cagcgtcatt ggcgtgttgg gaagaaaccc tctgccacag aggccagctt cagcctttgc 6120
ctaacaccgc aagggcaaat ggaaaggtaa acgggaagga gatgtctccc cagcaggcta 6180
tttgaggaca gtcttccctg cagaagatct caacctgggg tccacagagt ggaaatgtta 6240
gagtagggag ctaggcaaac atgagcagga caggtgaggg cccccacagg aatgtcaggc 6300
taccatcagg tgatggtcag gtggttgtta aactgtctct gtaaaataat aattggttgc 6360
agccagctcc aagcaaggac agtctctcaa tagatacaaa acaccctgat ctggtgatca 6420
gccgcttccc gataagatct caggagctgg gcaagcagcc tggagcatgc gcaccaagag 6480
gcaaaatggc ggaatttaac cagtatatga cctaccttcc tctgggaacg cacgactggt 6540
aaggggaaaa atgcctcaag tgagcatgcg cgcaacttca gtaatcacac tgtgcatgcg 6600
accccttcca agtgctggca ggtcaccaca tacgcggaca gcctgctgca agggaagaat 6660
caggggagat gagacgtaaa tcccagaact atgccaaata cataaaaccc caagttaagg 6720
gtcaggcagg gcacttagat ctctcaagtt gcctgcctga cccaagtgta gtgtacttcc 6780
ttttgttcct gctctaaaac tttttaataa actctcactc ctgctctaaa a 6831
<210> 57
<211> 3620
<212> DNA
<213> Homo sapiens
<400> 57
acctcgcagt ctccccaggt ccgcccagca gccgcgcttc agccagaata ctgggatctt 60
cagtggcagg aggagtaatc agaagacgga gatgaatttt aacactattt tggaggagat 120
tcttattaaa aggtcacagc agaaaaagaa gacatcgccc ttaaactaca aagagagact 180
ttttgtactt acaaagtcca tgctaaccta ctatgagggt cgagcagaga agaaatacag 240
aaaggggttt attgatgttt caaaaatcaa gtgtgtggaa atagtgaaga atgatgatgg 300
tgtcattccc tgtcaaaata agtatccatt tcaggttgtt catgatgcta acacacttta 360
catttttgca cctagtccac aaagcaggga cctgtgggtg aagaagttaa aagaagaaat 420
aaagaacaac aataatatta tgattaaata tcatcctaaa ttctggacag atggaagtta 480
tcagtgttgt agacaaactg aaaaattagc acccggatgt gaaaaataca atctttttga 540
gagcagtata agaaaagcac tacctccagc accagaaaca aagaagcgaa ggcctccccc 600
accaattcca ctagaagaag aagataatag tgaagaaatc gttgtagcca tgtatgattt 660
ccaagcagca gaaggacatg atctcagatt agagagaggc caagagtatc tcattttaga 720
aaagaatgat gttcattggt ggagagcaag agataaatat gggaatgaag gatatatccc 780
aagtaattac gtaacgggaa agaaatcaaa caacttagat caatatgaat ggtattgcag 840
aaatatgaat agaagcaagg cagagcaact cctccgcagt gaagataaag aaggtggttt 900
tatggtaagg gattccagtc aaccaggctt gtacacagtc tccctttata ccaagtttgg 960
aggagaaggt tcatcgggtt ttaggcatta tcatataaag gaaacaacaa catctccaaa 1020
gaagtattac ctagctgaaa aacatgcttt tggctccatt cctgagatta ttgaatatca 1080
taagcacaat gcagcaggac ttgtcaccag gcttcggtac ccagttagtg tgaaagggaa 1140
gaatgcaccc accactgcag gattcagcta tgagaaatgg gagattaacc cttcagaact 1200
gacctttatg agggaattgg gaagtggact gtttggagtg gtgaggcttg gcaaatggcg 1260
agcccagtac aaagtcgcaa tcaaagctat tcgggaaggt gcaatgtgcg aggaggactt 1320
tatagaagaa gctaaagtga tgatgaaact gacacacccg aagttagtgc agctttatgg 1380
tgtgtgcacc cagcagaaac caatatacat tgttactgag ttcatggaaa ggggctgcct 1440
tctgaatttc ctccgacaga gacaaggtca tttcagtaga gacgtactgc tgagcatgtg 1500
tcaggatgtg tgtgaaggga tggagtatct ggagagaaac agcttcatcc acagagatct 1560
ggctgccaga aattgtctag taagtgaggc gggagttgta aaagtatctg attttggaat 1620
ggccaggtat gttctggatg atcagtacac aagttcttct ggtgctaagt ttcctgtgaa 1680
gtggtgtcca cctgaagtgt ttaattacag ccgcttcagc agcaaatcag atgtctggtc 1740
atttggtgtt ttaatgtggg aagtattcac ggaaggcaga atgccttttg aaaaatacac 1800
caattatgaa gtggtaacca tggttactcg aggccaccga ctctaccagc cgaagttggc 1860
gtccaactat gtgtatgagg tgatgctgag atgttggcag gagaaaccag agggaaggcc 1920
ttctttcgaa gatctgctgc gcacaataga tgaactagtt gaatgtgaag aaacttttgg 1980
aagataagtg atgtgtgacc agtggctccc agattcccaa gcacaaggaa ggatgggcat 2040
tttgtggctt ttaatttatt gagcacttgg acatgtagat cattttactt atacagtgga 2100
aacacataaa taatttgctt ctagaccagc ctctgtctag acttgcttct agacagaatc 2160
tcccagagtg tggaaatgtt gccttagaaa tggtgattaa aatcactcat ttctattcat 2220
tcctcaggca cttgagtgac agttgtttac caggcactgt gtgtagcccc agggtttggc 2280
cattcagggg tgcacacatg ggaccatgtt agctgatgcc agttgaaggc cagggtattt 2340
gggaagggga agggtattag agtcatgacc aagcaaccct tctttttccc tttgacttct 2400
acagaaatct gggcctgaga cattgtctac aattgggttc tagatacatc aggaacccat 2460
cttggataaa taaataccta tcttttgttt tgaaaacatc tcagttttca agactgctct 2520
tagtattaca tgaacaatat ttgtatgctg tatatattgt aaatatatat aatatataaa 2580
gttatatatt tatgagaaac acgaattgtc ttttaattga aacttttaat cctgtagtat 2640
aggagttcac cttcttagga ctagagactg tgccttatag ctgttaattc atttccccct 2700
gaacatcaaa tatgcctgaa gagaagaaag tctagattct tctatgagta acgccccctc 2760
ctcactcagg taaatgtgtc tggggatgcc tgtccagctt aaccacgtgc atttggccta 2820
tgtaatcctg cccatggtgg ccgcagctaa tcagaatcag atggaaaatt aaaccgggta 2880
atctacttct aagccttaag aatattccct gggacacaga cactataatt ggaagtgctg 2940
agctctgggg cagaaggatc aggtgacctt cgcaacaaag tttgccccca cctcacatag 3000
gacccggaag cagcctgagc tgtggcggag gatccaggaa gctacggaga gaagcagcca 3060
gcatggtgtt ccgtgcctcc cggacgtttt tcaggaggcc tggttggact tgggttcctg 3120
gatggtggga ttgttgtaca gcctctcagg agaccctgct gtcaagactg tgtgtgtgga 3180
tttctcaccc ttagaagctc tactaagaca tcaacggaat tagggccttc ctttttgcct 3240
tgtgagcgcc aaggaaaaga aactatctcg gtcacgtgag cgccagcgaa aagaaactgt 3300
atcagtcatc cagagaccgt ttattgccca acacgttatt cttgctgttg gtggggtaac 3360
tagccgagga agacacagcg ccttcccttc aggagttgcg tctcctctgc aggccacgat 3420
ggtctgctct ggagcattgg gtgaacacac aggctggctg ctctgggcag cgccttcact 3480
ctgaccctgg agaaccattt catttcatcc tggtcagtct agagtctgtg caccaggcag 3540
tccatccact gaaggctgtg tttattcttt tcctgtgccc ctcataatgg aagaaagtaa 3600
actgcttatc ccgagcctta 3620
<210> 58
<211> 4216
<212> DNA
<213> Homo sapiens
<400> 58
agtttctctt ctcggccacc tcctgcatag agggtaccat tctgcgctgc tgcaagttac 60
ggaatgaaaa attagaacaa cagaaacatg gaaaacatgt tccttcagtc gtcaatgctg 120
acctgcattt tcctgctaat atctggttcc tgtgagttat gcgccgaaga aaatttttct 180
agaagctatc cttgtgatga gaaaaagcaa aatgactcag ttattgcaga gtgcagcaat 240
cgtcgactac aggaagttcc ccaaacggtg ggcaaatatg tgacagaact agacctgtct 300
gataatttca tcacacacat aacgaatgaa tcatttcaag ggctgcaaaa tctcactaaa 360
ataaatctaa accacaaccc caatgtacag caccagaacg gaaatcccgg tatacaatca 420
aatggcttga atatcacaga cggggcattc ctcaacctaa aaaacctaag ggagttactg 480
cttgaagaca accagttacc ccaaataccc tctggtttgc cagagtcttt gacagaactt 540
agtctaattc aaaacaatat atacaacata actaaagagg gcatttcaag acttataaac 600
ttgaaaaatc tctatttggc ctggaactgc tattttaaca aagtttgcga gaaaactaac 660
atagaagatg gagtatttga aacgctgaca aatttggagt tgctatcact atctttcaat 720
tctctttcac acgtgccacc caaactgcca agctccctac gcaaactttt tctgagcaac 780
acccagatca aatacattag tgaagaagat ttcaagggat tgataaattt aacattacta 840
gatttaagcg ggaactgtcc gaggtgcttc aatgccccat ttccatgcgt gccttgtgat 900
ggtggtgctt caattaatat agatcgtttt gcttttcaaa acttgaccca acttcgatac 960
ctaaacctct ctagcacttc cctcaggaag attaatgctg cctggtttaa aaatatgcct 1020
catctgaagg tgctggatct tgaattcaac tatttagtgg gagaaatagc ctctggggca 1080
tttttaacga tgctgccccg cttagaaata cttgacttgt cttttaacta tataaagggg 1140
agttatccac agcatattaa tatttccaga aacttctcta aacttttgtc tctacgggca 1200
ttgcatttaa gaggttatgt gttccaggaa ctcagagaag atgatttcca gcccctgatg 1260
cagcttccaa acttatcgac tatcaacttg ggtattaatt ttattaagca aatcgatttc 1320
aaacttttcc aaaatttctc caatctggaa attatttact tgtcagaaaa cagaatatca 1380
ccgttggtaa aagatacccg gcagagttat gcaaatagtt cctcttttca acgtcatatc 1440
cggaaacgac gctcaacaga ttttgagttt gacccacatt cgaactttta tcatttcacc 1500
cgtcctttaa taaagccaca atgtgctgct tatggaaaag ccttagattt aagcctcaac 1560
agtattttct tcattgggcc aaaccaattt gaaaatcttc ctgacattgc ctgtttaaat 1620
ctgtctgcaa atagcaatgc tcaagtgtta agtggaactg aattttcagc cattcctcat 1680
gtcaaatatt tggatttgac aaacaataga ctagactttg ataatgctag tgctcttact 1740
gaattgtccg acttggaagt tctagatctc agctataatt cacactattt cagaatagca 1800
ggcgtaacac atcatctaga atttattcaa aatttcacaa atctaaaagt tttaaacttg 1860
agccacaaca acatttatac tttaacagat aagtataacc tggaaagcaa gtccctggta 1920
gaattagttt tcagtggcaa tcgccttgac attttgtgga atgatgatga caacaggtat 1980
atctccattt tcaaaggtct caagaatctg acacgtctgg atttatccct taataggctg 2040
aagcacatcc caaatgaagc attccttaat ttgccagcga gtctcactga actacatata 2100
aatgataata tgttaaagtt ttttaactgg acattactcc agcagtttcc tcgtctcgag 2160
ttgcttgact tacgtggaaa caaactactc tttttaactg atagcctatc tgactttaca 2220
tcttcccttc ggacactgct gctgagtcat aacaggattt cccacctacc ctctggcttt 2280
ctttctgaag tcagtagtct gaagcacctc gatttaagtt ccaatctgct aaaaacaatc 2340
aacaaatccg cacttgaaac taagaccacc accaaattat ctatgttgga actacacgga 2400
aacccctttg aatgcacctg tgacattgga gatttccgaa gatggatgga tgaacatctg 2460
aatgtcaaaa ttcccagact ggtagatgtc atttgtgcca gtcctgggga tcaaagaggg 2520
aagagtattg tgagtctgga gctaacaact tgtgtttcag atgtcactgc agtgatatta 2580
tttttcttca cgttctttat caccaccatg gttatgttgg ctgccctggc tcaccatttg 2640
ttttactggg atgtttggtt tatatataat gtgtgtttag ctaaggtaaa aggctacagg 2700
tctctttcca catcccaaac tttctatgat gcttacattt cttatgacac caaagatgcc 2760
tctgttactg actgggtgat aaatgagctg cgctaccacc ttgaagagag ccgagacaaa 2820
aacgttctcc tttgtctaga ggagagggat tgggacccgg gattggccat catcgacaac 2880
ctcatgcaga gcatcaacca aagcaagaaa acagtatttg ttttaaccaa aaaatatgca 2940
aaaagctgga actttaaaac agctttttac ttggctttgc agaggctaat ggatgagaac 3000
atggatgtga ttatatttat cctgctggag ccagtgttac agcattctca gtatttgagg 3060
ctacggcagc ggatctgtaa gagctccatc ctccagtggc ctgacaaccc gaaggcagaa 3120
ggcttgtttt ggcaaactct gagaaatgtg gtcttgactg aaaatgattc acggtataac 3180
aatatgtatg tcgattccat taagcaatac taactgacgt taagtcatga tttcgcgcca 3240
taataaagat gcaaaggaat gacatttctg tattagttat ctattgctat gtaacaaatt 3300
atcccaaaac ttagtggttt aaaacaacac atttgctggc ccacagtttt tgagggtcag 3360
gagtccaggc ccagcataac tgggtcctct gctcagggtg tctcagaggc tgcaatgtag 3420
gtgttcacca gagacatagg catcactggg gtcacactca tgtggttgtt ttctggattc 3480
aattcctcct gggctattgg ccaaaggcta tactcatgta agccatgcga gcctctccca 3540
caaggcagct tgcttcatca gagctagcaa aaaagagagg ttgctagcaa gatgaagtca 3600
caatcttttg taatcgaatc aaaaaagtga tatctcatca ctttggccat attctatttg 3660
ttagaagtaa accacaggtc ccaccagctc catgggagtg accacctcag tccagggaaa 3720
acagctgaag accaagatgg tgagctctga ttgcttcagt tggtcatcaa ctattttccc 3780
ttgactgctg tcctgggatg gcctgctatc ttgatgatag attgtgaata tcaggaggca 3840
gggatcactg tggaccatct tagcagttga cctaacacat cttcttttca atatctaaga 3900
acttttgcca ctgtgactaa tggtcctaat attaagctgt tgtttatatt tatcatatat 3960
ctatggctac atggttatat tatgctgtgg ttgcgttcgg ttttatttac agttgctttt 4020
acaaatattt gctgtaacat ttgacttcta aggtttagat gccatttaag aactgagatg 4080
gatagctttt aaagcatctt ttacttctta ccatttttta aaagtatgca gctaaattcg 4140
aagcttttgg tctatattgt taattgccat tgctgtaaat cttaaaatga atgaataaaa 4200
atgtttcatt ttacaa 4216
<210> 59
<211> 2444
<212> DNA
<213> Homo sapiens
<400> 59
attactgaca caaacgctcc ctcagggcgt ccccgtctgg actacaggag aaagtttggg 60
aggcaggttc aacttttcaa cttggcgggg aattcctctc cctcttacac agtttgcagc 120
gcgggggcgg cggggtgaca gtccccgtgc atgaatcagc cacccctcag gctccgcccc 180
ggcgggggtc ggccggacgc tcgccccgca taaagcgggc acccgggccg cctggagcag 240
aaagccgcgc acctcctccc gccaggcgct ttctcggacg ccttgcccag cgggccgccc 300
gaccccctgc accatggacc ccgctcgccc cctggggctg tcgattctgc tgcttttcct 360
gacggaggct gcactgggcg atgctgctca ggagccaaca ggaaataacg cggagatctg 420
tctcctgccc ctagactacg gaccctgccg ggccctactt ctccgttact actacgacag 480
gtacacgcag agctgccgcc agttcctgta cgggggctgc gagggcaacg ccaacaattt 540
ctacacctgg gaggcttgcg acgatgcttg ctggaggata gaaaaagttc ccaaagtttg 600
ccggctgcaa gtgagtgtgg acgaccagtg tgaggggtcc acagaaaagt atttctttaa 660
tctaagttcc atgacatgtg aaaaattctt ttccggtggg tgtcaccgga accggattga 720
gaacaggttt ccagatgaag ctacttgtat gggcttctgc gcaccaaaga aaattccatc 780
attttgctac agtccaaaag atgagggact gtgctctgcc aatgtgactc gctattattt 840
taatccaaga tacagaacct gtgatgcttt cacctatact ggctgtggag ggaatgacaa 900
taactttgtt agcagggagg attgcaaacg tgcatgtgca aaagctttga aaaagaaaaa 960
gaagatgcca aagcttcgct ttgccagtag aatccggaaa attcggaaga agcaatttta 1020
aacattctta atatgtcatc ttgtttgtct ttatggctta tttgccttta tggttgtatc 1080
tgaagaataa tatgacagca tgaggaaaca aatcattggt gatttattca ccagttttta 1140
ttaatacaag tcacttttta aaaaatttgg atttttttat atataactag ctgctattca 1200
aatgtgagtc taccattttt aatttatggt tcaactgttt gtgagactga attcttgcaa 1260
tgcataagat ataaaagcaa atatgactca ctcatttctt ggggtcgtat tcctgatttc 1320
agaagaggat cataactgaa acaacataag acaatataat catgtgcttt taacatattt 1380
gagaataaaa aggactagca aataaaactc attttgcatt taaaagttgg attatatttt 1440
agtcccaaga agacaaagtc gcagattaac aacactttaa aaatattact cccattttat 1500
tgtgttagat tgcagtacaa tgaatgaata aggggattta tttaaaagat cttaactttc 1560
ttgactgatt taaaaagcta atcaatttat taaagccaga aatgttctcc tctgggaaag 1620
caatttctat ctatttatct accaatcccc actcacatgt atatgtttgt gtttacatag 1680
agatagatgg ttttaagggt tttcctattg ttaaattatt tcctaagaca ttgtgggttg 1740
gagaccacta aacttataaa aaaccaagga aagtaaagtt tttcaaatgt ttatactgtt 1800
taaggtgttt atttatataa accatgcatg agaaaccatg cataaattta ataatttaaa 1860
tttcaccagt aaattatcat tgattaaata tggtcatacc aatgaaatag gttttttctt 1920
tctctgtaat aaaacaattt ttctaaattc ttatgttttc atagcaagat taacatattt 1980
aattacaaat taaatatgca aaatgacaaa tgcgtttacc ttttgcttga acaatctttc 2040
atttaaaaat ttatcccagt tattttgaca aataggtata tgcctgagaa ctttgaatga 2100
tgctgaaagc tagaagcaaa ccaggtactc ttcagtcagg gactggttga agattttatg 2160
gatgaggagt tagcaaaata tctatatatg catatcttct gactcccagg atacataaga 2220
aacacagggc ctagaacagt atgaataaac acacatatac acaaacatca cagaagatac 2280
taaagatatt aaaaatgttt acctatagag gtttggagag aacagagggg tggacagttg 2340
tggagataat atttgtgtaa atataactgt gatatagttt ttatcttgga ccatgtaaat 2400
atttgacata attaataatc aaaattaaat aaaaaagaaa aagc 2444
<210> 60
<211> 1634
<212> DNA
<213> Homo sapiens
<400> 60
gggtggggaa gcttagagac cggtgaggga gcagagctgg ggcgcctgtg tacagggata 60
gagcccggcg gcagcagggc gcggcttccc tttcccgggg cctggggccg caatcaggtg 120
gagtcgagag gccggaggag gggcaggagg aaggggtgcg gtcgcgatcc ggacccggag 180
ccagcgcgga gcacctgcgc ccgcggctga caccttcgct cgcagtttgt tcgcagttta 240
ctcgcacacc agtttccccc accgcgcttt ggattagtgt gatctcagct caaggcaaag 300
gtgggatatc atggcatcta tctgggttgg acaccgagga acagtaagag attatccaga 360
ctttagccca tcagtggatg ctgaagctat tcagaaagca atcagaggaa ttggaactga 420
tgagaaaatg ctcatcagca ttctgactga gaggtcaaat gcacagcggc agctgattgt 480
taaggaatat caagcagcat atggaaagga gctgaaagat gacttgaagg gtgatctctc 540
tggccacttt gagcatctca tggtggccct agtgactcca ccagcagtct ttgatgcaaa 600
gcagctaaag aaatccatga agggcgcggg aacaaacgaa gatgccttga ttgaaatctt 660
aactaccagg acaagcaggc aaatgaagga tatctctcaa gcctattata cagtatacaa 720
gaagagtctt ggagatgaca ttagttccga aacatctggt gacttccgga aagctctgtt 780
gactttggca gatggcagaa gagatgaaag tctgaaagtg gatgagcatc tggccaaaca 840
agatgcccag attctctata aagctggtga gaacagatgg ggcacggatg aagacaaatt 900
cactgagatc ctgtgtttaa ggagctttcc tcaattaaaa ctaacatttg atgaatacag 960
aaatatcagc caaaaggaca ttgtggacag cataaaagga gaattatctg ggcattttga 1020
agacttactg ttggccatag ttaattgtgt gaggaacacg ccggcctttt tagccgaaag 1080
actgcatcga gccttgaagg gtattggaac tgatgagttt actctgaacc gaataatggt 1140
gtccagatca gaaattgacc ttttggacat tcgaacagag ttcaagaagc attatggcta 1200
ttccctatat tcagcaatta aatcggatac ttctggagac tatgaaatca cactcttaaa 1260
aatctgtggt ggagatgact gaaccaagaa gataatctcc aaaggtccac gatgggcttt 1320
cccaacagct ccaccttact tcttctcata ctatttaaga gaacaagcaa atataaacag 1380
caacttgtgt tcctaacagg aattttcatt gttctataac aacaacaaca aaagcgatta 1440
ttattttaga gcatctcatt tataatgtag cagctcataa atgaaattga aaatggtatt 1500
aaagatctgc aactactatc caacttatat ttctgctttc aaagttaaga atctttatag 1560
ttctactcca ttaaatataa agcaagataa taaaaattgt tgcttttgtt aaaagtaaaa 1620
aaaaaaaaaa aaaa 1634
<210> 61
<211> 8245
<212> DNA
<213> Homo sapiens
<400> 61
ggaggaagaa aactcaagtg aaactgactc tgctagaaca gtgccgtgct tttccacaga 60
aggttagacc ctgaaagaga tggctcagca ccacctatgg atcttgctcc tttgcctgca 120
aacctggccg gaagcagctg gaaaagactc agaaatcttc acagtgaatg ggattctggg 180
agagtcagtc actttccctg taaatatcca agaaccacgg caagttaaaa tcattgcttg 240
gacttctaaa acatctgttg cttatgtaac accaggagac tcagaaacag cacccgtagt 300
tactgtgacc cacagaaatt attatgaacg gatacatgcc ttaggtccga actacaatct 360
ggtcattagc gatctgagga tggaagacgc aggagactac aaagcagaca taaatacaca 420
ggctgatccc tacaccacca ccaagcgcta caacctgcaa atctatcgtc ggcttgggaa 480
accaaaaatt acacagagtt taatggcatc tgtgaacagc acctgtaatg tcacactgac 540
atgctctgta gagaaagaag aaaagaatgt gacatacaat tggagtcccc tgggagaaga 600
gggtaatgtc cttcaaatct tccagactcc tgaggaccaa gagctgactt acacgtgtac 660
agcccagaac cctgtcagca acaattctga ctccatctct gcccggcagc tctgtgcaga 720
catcgcaatg ggcttccgta ctcaccacac cgggttgctg agcgtgctgg ctatgttctt 780
tctgcttgtt ctcattctgt cttcagtgtt tttgttccgt ttgttcaaga gaagacaaga 840
tgctgcctca aagaaaacca tatacacata tatcatggct tcaaggaaca cccagccagc 900
agagtccaga atctatgatg aaatcctgca gtccaaggtg cttccctcca aggaagagcc 960
agtgaacaca gtttattccg aagtgcagtt tgctgataag atggggaaag ccagcacaca 1020
ggacagtaaa cctcctggga cttcaagcta tgaaattgtg atctaggctg ctgggctgaa 1080
ttctccctct ggaaactgag ttacaaccac caatactggc aggttccctg gatccagatc 1140
ttctctgccc aactcttact gggagattgc aaactgccac atctcagcct gtaagcaaag 1200
caggaaacct tctgctgggc atagcttgtg cctaaatgga caaatggatg catacccttc 1260
ctgaaatgac tcccttctga atgaatgaca aagcaggtta cctagtatag ttttcccaaa 1320
cttcttccca tcatagcaca tgtagaaaat aatattttta tggcacactg ggataaacaa 1380
gcaagattgc tcacttctgg aagctgcata tgactagagg cctcttgtga ctggaggtaa 1440
caaccctgcc cagtaactgt gggagaaggg gatcaatatt ttgcacacct gtaataggcc 1500
atggcacacc agccaagatg ctctgctcac agtcagtatg tgtgaagatc cctggtgcgt 1560
ggccttcacc acgcatcttg agcaaattag gaaaatgtac ccttcgcttg aggcagatgc 1620
agcccttccc ccgagtgcat ggcttggaga gcagaatgtg ggctgcatat aagcacactc 1680
atccctttgt ctgggaatct ttgtgcaggg cataacaggc ttagtaagtc caaacacaga 1740
tgacagtgct gtgtgggtct ctgtcagagt tgtggctctc agccatgtag acacactctc 1800
caaatggagt gttggaaaat gttctttctg cagggtctag agactgctgg gacacttttc 1860
ttggagtgct acttcagaag ccttatagga ttttctttct ggccaagatt tccttctgta 1920
tcactccaag cagcctcagc agaagaagca gccatgccca gtattcccac tctccaaaag 1980
gaactgacca gcttatattt ctcacacttc tggggaactg ggtataatcc aaccatcaaa 2040
atagaagacc ttgcaagaag cagagtcatt ctccagaagg aacttgggag atgatggtgc 2100
agatgatgaa actgggttca tcccagttcc aaagactcag agaactagag tttaagctga 2160
ggcagagtgc cgccaccctg gcatgcccca caaacagatc accagccagc ttacacaggc 2220
attaactctc ctcaatgagg aagaatcatt cacaactgag caagacattc atatgatcat 2280
ttaaggaagt gtttccctta tgtgttagca agtataatcg gctaactcct aaatcccaat 2340
gaatagtcct aggctggaca gcaatgggct gcaattaggc agataaagac atcagtccca 2400
gtaaatgaat ccatagactc atctagcacc aactaccatt agcactatgt taggagctgc 2460
aaggccccaa agtagaagat gtgcataatg tctgctcttg tgtagctcag gagacaattc 2520
cagcacagac actacagtta acgctgaact gcagctgcaa gtaatagcat gaacagtcag 2580
aaaaatacct tatgaggggg cagggctgaa gctgggcctt gaaggatgga tgaaatttgg 2640
atagagaatg aggaagacag agggcctcca agtgagagaa gcatgaaaaa tgagcagggg 2700
cctggatcag tggggtgtat tcagagcacc tctccagatg caccatgcat gctcacagtc 2760
ccttgcctat gtgtggcaga gtgtcccagc cagatgtgtg ccctcacccc atgtccattt 2820
acatgtcctt caatgcccac ctcaaaaggt acctcttctg taaagctttc cctggtatca 2880
ggaatcaaaa ttaatcaggg atcttttcac actgctgttt tttcctcttt ggtccttcta 2940
tcactaaaac tcatctcatt cagccttaca gcataactaa ttatttgttt tcctcactac 3000
attgtacatg tgggaattac agataaacgg aagccggctg gggtggtggc tcacgcctgt 3060
aatcccaaca ctttgggagg ccaaggcagg cggatcacct gaggtcagga gttcgagatt 3120
agtctggcca acatggtgaa accccatctc tactaaaaat acgaaattag ccaggtgtgg 3180
tggcacacat ctgtagtccc agctactctg gaggctgaga caggagaatc gcttgaaccc 3240
aggaagtgga ggttgcagtg agctgagatc acaccactgc actccagcct gggagagaca 3300
gagtgagact ccatctcgaa aaaaaaaaaa agatagaagc caataagcat ggtgcaatca 3360
aattctggca agcattaaat atcaggatgc agctgggcac ggtggctcac gcctgtaatc 3420
ccagcacttt gggaggccaa ggtgggcgga tcacttgagg tcaggaattt gagaggatcc 3480
tggccagcat ggcaaaaccc catctgtact taaaatacaa aaaaattagc tgggcgtggt 3540
ggtgcacacc tgtaatccca gctacttggg aggctgaggt gggagaattg cttgaacctg 3600
ggaggtggag gttgcagtga gctgagatcc tgccactgca ctccaggctg ggcaacagag 3660
tgagaccatg tctcaaaaaa taaaaataaa ataaaataat atcaggatgc atacatcaga 3720
ggctgttcct agtgtaaagg cactttggag ggagaagact ttcagagtta ggcagaccaa 3780
ctaagaggtc agctgaagca cctaaccagt tgtaaggagg tgaaagacag caccccaaga 3840
agagacgtgc aggaaggagg aaagaggctt ggtcataaag gatggaggaa ttccaaagtg 3900
acactgaaca ggctgcgttt atcctaaaat aaaaccactc ctcactctgt ggatgcgttg 3960
aagactcatt cccaaacatc tttattctct aacttgccct cttcctcttc ctaatatgct 4020
cactcaagta aaattactag tgtcctaatg cccctatgca tattgtcaaa aataaaaatc 4080
agaagcaggt tagatctgtt aggtcttcca gaagagcaaa cctgggatga agccagagcc 4140
caggaattct gaaggtagcc tttggactca ggacacccta ctcttgtctc tcctctcagt 4200
ttctctgcta tgaatctcct gattcatgaa cacgttatct gttcaccctt ctctctaggt 4260
cttagttctt agattttcct tctgtaaaat gcatgtgatc ttattttccc ctccacaact 4320
ttccagatga actagactgt gaccaagagg tctataaaat caaagcatca tggaacagga 4380
tcttgtatca gaccaaagtg tgccagtttt taaaaatgtg catcaaaatg gaagtctcag 4440
agacagagcc ctctggtgga aagttctagt aggttaggac agtcctgcct gcagacacct 4500
tgggctttac tgagggactc aactgagaaa atgaggaatg ttgcagctca tgattcttag 4560
aagaagaaag tgaagcttgt ttaaaatatg atttaaaaaa tctgtagaac actgtaaact 4620
acacaggcta tgagggaata gcctggttgg gccagcttgg aaatcgggca caggcaggaa 4680
ggggcctgtc tggtttgggc cgtgtccaca gagagcactt cttaggtcct gcctggagag 4740
aaggaatggc tgggctatat tttcttccag actcattatt tttcttctgt ttgacttttc 4800
tctgaatttc ccttgatttg tataaatttt ctcaataatt agtgacagtg tctactgatt 4860
gtaaaatgaa gcttgaaggc caggcgcagt ggctcatgcc tgtaatccta gaattttggg 4920
aggccaaggt gggtggatca caaggagttc gagaccagcc tggccaaggt tgtgaaaccg 4980
cgtctctact aaaaatacaa aaaaattagc cgggcatggt ggcacgtgcc tgtagtccca 5040
gctactcagg aagctgaggc aacagaatca cttgaacctg ggaggtggag gttgcagtga 5100
gccgagatca cgccactgca ctccagcctg ggcgagagag tgagactccg tctcaaaaaa 5160
aaaaaaaaaa aaaaaagttt gaagaacaaa gacaataaga ggaaatataa tgagtggtca 5220
taaatgtggg ctctgacagt agagtgcctg ggtctgcatc ctggtttctt agtcatgtga 5280
ccttaggcaa gttactttaa cctcgctgta cctcaggttg tccatctgta aaatggggat 5340
aataatagtg cctacctttt aaggttgatg tggggattaa atgaggtgtt gctcatacag 5400
gaatgtgcct gtgcatggca aagttcggga aattttttat aagctgttct aggcctgaaa 5460
tcttcagaag atgctaatct aaattcatga aataagcttc ttacaacaga aatgctgcta 5520
gtattatgca aaattaatgt tgtatatcaa acttttaact ctcatccctc cttattcaga 5580
tatattttgt tataagcaat gtttgttccc ctcgttatta taccacagtc tacttacctg 5640
atgctatatc tgcctcccca gttagactga gagaacaggg gatataccta aataataata 5700
ataataataa taataataaa taataatgga gagctccttg aagataggga gcctgtaaga 5760
atcattgagg gcttattttg tataccaact gctaaactag atgcttcata cattgttgtc 5820
aatactcatg acagccttgt aaagtagaaa ttaattcttc cagttaacac taaggctgac 5880
atatgaatac cttggcaaat ctggaaagct gggaagacag tatttgaatt caagacttct 5940
tgtcaccaag ggccatgcac ttgtactctg ccatgtggcc cttttttacc tcctgtggat 6000
tctccctacc tggtacttgg ccttaggtgt acacacacct ggcactttgc ttgacacata 6060
ataggtggac cacaaatatc tactaaatga atatttgcat atagtaatat tttaaggtac 6120
taaaagcagc tcaaagtaaa tatattaata tattaattcc attgctatct ggataaccac 6180
tcaactttcc tgctgaaaat gcccatttaa ttaaagaagg ttggatagag ctctctatat 6240
gcattttgga caggcagggg tttcaggtca taaacattct gatgagttaa tataaaataa 6300
gagaaactgt aaatttccac tactaaaaat cacaaaaata acagaaacaa aagaagagat 6360
aagaatttgg ggaattgtgc tgaacaattt agtggttaaa aaaaacaact gtgcatgttt 6420
agacttaaat aagcccccat ccaagtgtga ggggtccagt aatttttcaa aacatatgaa 6480
agtgttaata catttcgaca aaggaccatt aaaaaagtcc tgaattctga cttgagggag 6540
gaaagtaatg actaatacat tctctagaga cttgcagact ttgggaattc ataaaggaat 6600
ggatgataat tattaactgt tgctggctga ttgcccagac agttctcaac agccctgtac 6660
aagtctctgg gtttgggatg gatcaattct gagactggaa aatggccaaa tctttgcaaa 6720
tgagaaatat ttttcttata agttcttatt gtaggcaaat aattacatag attattcatc 6780
agagaatttt taaatgctca taatctcaac tctttcattt acaacttgta tttccaatag 6840
tttatgggtc atctctgcat agatgtcaga agtcacctca agtttagcgt gtccaaaatc 6900
taactcacag gtctgtttct gacctcccaa cttgctttcc ttgtgttttt cctatgctaa 6960
tgatccacca taatcaaaat aattaacatt tatccagtgc ctactatgta ctattccctg 7020
tcctgtttta catttactca tttaaagtcc ataagaaaca ttaaatctca tctgccttct 7080
gaagaagata caaccatgct ctcttttaca aagtaggaaa ctgggtcaca gaaaggtgaa 7140
gtctttaagg ctgaatcaca gtagctcatc ctagtaaata gaaaagccag gattcaactc 7200
caggggctgg gtgcagaact gctattcttc actgcttcac caatcagcag ctacccaagg 7260
cagaaaactt tttcatcctt ggctccttca ttctccctgt caccccagat cccctctaca 7320
tctagtcaga gaataggtcc tgtcaattcc aacttctcta tatggctcct ctcaggcatg 7380
tgcccttaat tggcctaatt ctctaataca ccttccctct acatgctcac tccctcagat 7440
cattgcttta tcacgtgtta cctgggttgc tattacataa agagcaatct ttctaaaatg 7500
aggatcttat cacttcactt ccacactaaa atgtttttcc tggggaacca cactccttag 7560
caatctgacc catcagacct tccaggctgt ctcctgcctg ctccctaagg ctccagccac 7620
acagaattat catgggccca cacacccacc aaatcctccc atgcctttgc ccatgttgtc 7680
tgggatgccc ttctctccct tctgtctaca tcaagcatca gactgaatat ccctcttgtg 7740
cggccttcta aaacctcccg tccaaagcga aatatattgc cctctattta tacttttaca 7800
gcatttggca cacaagtaca gagtagtagc tttttatcac attctctgat aattatatag 7860
atatggtatt tcttagctct ctctccaact ggctaataag ttgctttttg tctgagtgcc 7920
taattttgtg ttttgtgtct gagtgcctca gttcctcaaa aaaaggtttt ttgattagtt 7980
cattattcat ttgaacatgg aaattatgct cactagtggc aaatgccact aaccgtattc 8040
cagaagctag gtgtcatgtt tgcaataaga tatattatcc cttctacaag tcacctttta 8100
tttcaggcat ttgtaaatgc ccattaataa agtatggttc ataaatttta ccttgtaagt 8160
gcctaagaaa tgagactaca agctccattt cagcaggaca caataaatat tattttataa 8220
tgcatctaaa aaaaaaaaaa aaaaa 8245
<210> 62
<211> 940
<212> DNA
<213> Homo sapiens
<400> 62
cttggttccg cccgcgcgtc acgtgacccc agcgcctact tgggctgagg agccgccgcg 60
tcccctcgcc gagtcccctc gccagattcc ctccgtcgcc gccaagatga tgtgcggggc 120
gccctccgcc acgcagccgg ccaccgccga gacccagcac atcgccgacc aggtgaggtc 180
ccagcttgaa gagaaagaaa acaagaagtt ccctgtgttt aaggccgtgt cattcaagag 240
ccaggtggtc gcggggacaa actacttcat caaggtgcac gtcggcgacg aggacttcgt 300
acacctgcga gtgttccaat ctctccctca tgaaaacaag cccttgacct tatctaacta 360
ccagaccaac aaagccaagc atgatgagct gacctatttc tgatcctgac tttggacaag 420
gcccttcagc cagaagactg acaaagtcat cctccgtcta ccagagcgtg cacttgtgat 480
cctaaaataa gcttcatctc cgggctgtgc cccttggggt ggaaggggca ggattctgca 540
gctgcttttg catttctctt cctaaatttc attgtgttga tttctttcct tcccaatagg 600
tgatcttaat tactttcaga atattttcaa aatagatata tttttaaaat ccttacagat 660
tgcctccttt gttttagact tttttcttcg tctgaaccac cccgggcagg tccttcccct 720
cgggggcatg gagggcggag agactgcctg gctcacacag caagcaggtg gtggacccag 780
gattcacacc tgcccactcc ggcccgcgtt cctaaccacc actctttaca tgttggtgct 840
ttgactctta ggtcctggcc ccaagcttca gtttctccca taaaataaaa gagtgtgagt 900
aaatccaatt ccagagcata actggctcca gatctcagat 940
<210> 63
<211> 1398
<212> DNA
<213> Homo sapiens
<400> 63
aggcgcagtt actgatatag ccaaggtggg acactactgg agggagctag aagggatcag 60
ccagccatgc ctccagttca ggtacttggc attgctaagc tcagaacagg acttgccagt 120
gtctagatga aaaagaggag agatctcaag agggataacc aattggctgg caaagtaaca 180
aatgaaaagt aacctgactc tattgacctg cttaaccctg catggggggg aaggatggaa 240
aggagcagct gtttgctttg aaacggtgga acagttttgc agccttagaa aatggcatgt 300
aacataccta accaaagaca gcggactctg tcaacaacag gagaagctct atacgaaatt 360
cttggtctgc ataagggagc atcaaatgaa gaaattaaga aaacctacag aaaattggcc 420
ctgaaacacc atccagacaa gaatccagat gatccagctg ctactgagaa gtttaaagaa 480
atcaacaacg cccacgcaat acttaccgac atttcaaaga gaagcatata cgacaagtac 540
ggatcgctgg gactctacgt ggccgagcag tttggagacg aaaacgttaa cacctacttc 600
atgctgtcga gctggtgggc aaaggccctg tttgtcatcg ttggcctctt gacgggctgc 660
tacttttgct gctgcctgtg ctgctgctgc aactgctgct gtggacactg ccggcccgag 720
tcatcagtgc cagaagagga cttctatgtg tccccagagg atctggagga gcagatcaag 780
tctgacatgg aaaaagatgt ggactttcca gtttttctcc agcctacaaa tgcaaatgag 840
aaaacacagc taatcaaaga aggatctcga agttattgca cagactcttg atattgagcc 900
ctcagagagt ccacagtccc tcctctcagt tcagtcttgt ctccagatgg tcgtagggga 960
gcgtgtgggg cataaagtgc tgtgaacttt tccatcttgt tgttttattt ttgggttagg 1020
aaaacatgat tgctatataa ttttctcagt atgcagactt tctctctgag tagaatttct 1080
tatgaaacac attcaatttg ggtgaataaa ggcctgaaga gttattttac cctccttgcc 1140
tgatgtagga cagtggaatt gtacagcctt tatgaacctg ccctttatgt gtggcagatc 1200
tgattcctaa ctgaccaaag taatattcca gaacaaaagc cacttttctt acatttaaca 1260
caatattcat atctaccacg aacatgatca tcaaaatata tgagaactta taaagagttt 1320
ttgtgtgtgg agcctcttcc gtgtcaatat tcaataaagt tatagaaatg tttcaagagc 1380
aaaaaaaaaa aaaaaaaa 1398
<210> 64
<211> 4617
<212> DNA
<213> Homo sapiens
<400> 64
atctaagctt ctctgtcttc ctccctccct cccttcctct tactctcatt catttcatac 60
acactggctc acacatctac tctctctctc tatctctctc agaatgacaa ttctaggtac 120
aacttttggc atggtttttt ctttacttca agtcgtttct ggagaaagtg gctatgctca 180
aaatggagac ttggaagatg cagaactgga tgactactca ttctcatgct atagccagtt 240
ggaagtgaat ggatcgcagc actcactgac ctgtgctttt gaggacccag atgtcaacat 300
caccaatctg gaatttgaaa tatgtggggc cctcgtggag gtaaagtgcc tgaatttcag 360
gaaactacaa gagatatatt tcatcgagac aaagaaattc ttactgattg gaaagagcaa 420
tatatgtgtg aaggttggag aaaagagtct aacctgcaaa aaaatagacc taaccactat 480
agttaaacct gaggctcctt ttgacctgag tgtcgtctat cgggaaggag ccaatgactt 540
tgtggtgaca tttaatacat cacacttgca aaagaagtat gtaaaagttt taatgcacga 600
tgtagcttac cgccaggaaa aggatgaaaa caaatggacg catgtgaatt tatccagcac 660
aaagctgaca ctcctgcaga gaaagctcca accggcagca atgtatgaga ttaaagttcg 720
atccatccct gatcactatt ttaaaggctt ctggagtgaa tggagtccaa gttattactt 780
cagaactcca gagatcaata atagctcagg ggagatggat cctatcttac taaccatcag 840
cattttgagt tttttctctg tcgctctgtt ggtcatcttg gcctgtgtgt tatggaaaaa 900
aaggattaag cctatcgtat ggcccagtct ccccgatcat aagaagactc tggaacatct 960
ttgtaagaaa ccaagaaaaa atttaaatgt gagtttcaat cctgaaagtt tcctggactg 1020
ccagattcat agggtggatg acattcaagc tagagatgaa gtggaaggtt ttctgcaaga 1080
tacgtttcct cagcaactag aagaatctga gaagcagagg cttggagggg atgtgcagag 1140
ccccaactgc ccatctgagg atgtagtcat cactccagaa agctttggaa gagattcatc 1200
cctcacatgc ctggctggga atgtcagtgc atgtgacgcc cctattctct cctcttccag 1260
gtccctagac tgcagggaga gtggcaagaa tgggcctcat gtgtaccagg acctcctgct 1320
tagccttggg actacaaaca gcacgctgcc ccctccattt tctctccaat ctggaatcct 1380
gacattgaac ccagttgctc agggtcagcc cattcttact tccctgggat caaatcaaga 1440
agaagcatat gtcaccatgt ccagcttcta ccaaaaccag tgaagtgtaa gaaacccaga 1500
ctgaacttac cgtgagcgac aaagatgatt taaaagggaa gtctagagtt cctagtctcc 1560
ctcacagcac agagaagaca aaattagcaa aaccccacta cacagtctgc aagattctga 1620
aacattgctt tgaccactct tcctgagttc agtggcactc aacatgagtc aagagcatcc 1680
tgcttctacc atgtggattt ggtcacaagg tttaaggtga cccaatgatt cagctattta 1740
aaaaaaaaag aggaaagaat gaaagagtaa aggaaatgat tgaggagtga ggaaggcagg 1800
aagagagcat gagaggaaag aaagaaagga aaataaaaaa tgatagttgc cattattagg 1860
atttaatata tatccagtgc tttgcaagtg ctctgcgcac cttgtctcac tccatcctga 1920
caataatcct gggaggtgtg tgcaattact acgactactc tcttttttat agatcattaa 1980
attcagaact aaggagttaa gtaacttgtc caagttgttc acacagtgaa gggaggggcc 2040
aagatatgat ggctgggagt ctaattgcag ttccctgagc catgtgcctt tctcttcact 2100
gaggactgcc ccattcttga gtgccaaacg tcactagtaa cagggtgtgc ctagataatt 2160
tatgatccaa actgagtcag tttggaaagt gaaagggaaa cttacatata atccctccgg 2220
gacaatgagc aaaaactagg actgtcccca gacaaatgtg aacatacata tcatcactta 2280
aattaaaatg gctatgagaa agaaagaggg ggagaaacag tcttgcgggt gtgaagtccc 2340
atgaccagcc atgtcaaaag aaggtaaaga agtcaagaaa aagccatgaa gcccatttgg 2400
tttcattttt ctgaaaatag gctcaagagg gaataaatta gaaactcaca atttctcttg 2460
tttgttacca agacagtgat tctcttgctg ctaccaccca actgcatccg tccatgatct 2520
cagaggaaac tgtcgctgac cctggacatg ggtacgtttg acgagtgaga ggaggcatga 2580
cccctcccat gtgtatagac actaccccaa cctaaattca tccctaaatt gtcccaagtt 2640
ctccagcaat agaggctgcc acaaacttca gggagaaaga gttacaagta catgcaatga 2700
gtgaactgac tgtggctaca atcttgaaga tatacggaag agacgtatta ttaatgcttg 2760
acatatatca tcttgccttt cttggtctag actgacttct aatgactaac tcaaagtcaa 2820
ggcaactgag taatgtcagc tcagcaaagt gcagcaaacc catctcccac aggcctccaa 2880
accctggctg ttcacagaac cacaaagggc agatgctgca cagaaaacta gagaaggggt 2940
cataggttca tggttttgtt tgagatttgt tgctactgtt tttctgtttt gaattttctt 3000
ctttgttctg tttttacttt atttaggggg actaggtgtt tctgatattt tagttttctt 3060
gtttgttttg ttttgtgttg tctgtgaatg gggttttaac tgtggatgaa tggaccttat 3120
ctgttggctt aaaggactgg taagatcaga ccatcttatt cttcaggtga atgttttact 3180
ttccaaagtg ctctcctctg caccagcagt aataaataca atgccataat cccttaggtt 3240
tgcctagtgc ttttgcaatt ttcaaagcac ttccataagc attccttcca cctccttgat 3300
aggcatttat ggaaagcctg ctacatgtca atcatactgt taggcacagg ggacctaaag 3360
acacataaaa ggatggcatt ctgcctcata aattgcaaaa cctaatgaaa gtgactgctt 3420
ggtaaacaaa ttattattat attataaaat gctataaaag agccatattg aaagtgccct 3480
gttggagaca gggcaaatgc cacaaaaatg atgtaaattt acatggagga aaagtagaat 3540
ctgcctggtt tgtaggcagc agaagacatt tttcatcagt gggcaggtgt tctttacctt 3600
ttgtagaaat gggagtcaag tctcaaatag gaggctccac aaaatctcat gccaggtctc 3660
tgatacctta ttcacagaag ttctttgaag tatttattgt tattttcttt gacttatggg 3720
aaaactggga cacaggaaga caggtaaatt acccaacctc acacgttaag tcagaactgg 3780
gagccataat tttgtatccc tggtataaat agacaatctc ttgaagaaat gaagagatga 3840
ccatagaaaa acatcgagat atctccagct ctaaaatcct ttgtttcaat gttgtttggc 3900
atatgttatc tttggaattt agtgtctgag cctctgtctg ttactgtagt atttaaaatg 3960
catgtattat aatcatataa tcataactgc tgttaattct tgattatata cctagggaca 4020
atgtgtaatg taagattact aattggttct gcccaatctc ctttcagatt ttattaggaa 4080
aaaaaaataa acctcctgat cggagacaat gtattaatca gaagtgtaaa ctgccagttc 4140
tatatagcat gaaatgaaaa gacagctaat ttggtccaac aaacatgact gggtctaggg 4200
cacccaggct gattcagctg atttcctacc agcctttgcc tcttccttca atgtggtttc 4260
catgggaatt tgcttcagaa aagccaagta tgggctgttc agaggtgcac acctgcattt 4320
tcttagctct tctagagggg ctaagagact tggtacgggc caggaagaat atgtggcaga 4380
gctcctggaa atgatgcaga ttaggtggca tttttgtcag ctctgtggtt tattgttggg 4440
actattcttt aaaatatcca ttgttcacta cagtgaagat ctctgattta accgtgtact 4500
atccacatgc attacaaaca tttcgcagag ctgcttagta tataagcgta caatgtatgt 4560
aataaccatc tcatatttaa ttaaatggta tagaagaaca aaaaaaaaaa aaaaaaa 4617
<210> 65
<211> 1737
<212> DNA
<213> Homo sapiens
<400> 65
tagggcctcc tctaagtctt gagcccgcag ttcctgagag aagaaccctg aggaacagac 60
gttccctcgc ggccctggca cctctaaccc cagacatgct gctgctgctg ctgcccctgc 120
tctgggggag ggagagggcg gaaggacaga caagtaaact gctgacgatg cagagttccg 180
tgacggtgca ggaaggcctg tgtgtccatg tgccctgctc cttctcctac ccctcgcatg 240
gctggattta ccctggccca gtagttcatg gctactggtt ccgggaaggg gccaatacag 300
accaggatgc tccagtggcc acaaacaacc cagctcgggc agtgtgggag gagactcggg 360
accgattcca cctccttggg gacccacata ccaagaattg caccctgagc atcagagatg 420
ccagaagaag tgatgcgggg agatacttct ttcgtatgga gaaaggaagt ataaaatgga 480
attataaaca tcaccggctc tctgtgaatg tgacagcctt gacccacagg cccaacatcc 540
tcatcccagg caccctggag tccggctgcc cccagaatct gacctgctct gtgccctggg 600
cctgtgagca ggggacaccc cctatgatct cctggatagg gacctccgtg tcccccctgg 660
acccctccac cacccgctcc tcggtgctca ccctcatccc acagccccag gaccatggca 720
ccagcctcac ctgtcaggtg accttccctg gggccagcgt gaccacgaac aagaccgtcc 780
atctcaacgt gtcctacccg cctcagaact tgaccatgac tgtcttccaa ggagacggca 840
cagtatccac agtcttggga aatggctcat ctctgtcact cccagagggc cagtctctgc 900
gcctggtctg tgcagttgat gcagttgaca gcaatccccc tgccaggctg agcctgagct 960
ggagaggcct gaccctgtgc ccctcacagc cctcaaaccc gggggtgctg gagctgcctt 1020
gggtgcacct gagggatgca gctgaattca cctgcagagc tcagaaccct ctcggctctc 1080
agcaggtcta cctgaacgtc tccctgcaga gcaaagccac atcaggagtg actcaggggg 1140
tggtcggggg agctggagcc acagccctgg tcttcctgtc cttctgcgtc atcttcgttg 1200
tagtgaggtc ctgcaggaag aaatcggcaa ggccagcagc gggcgtggga gatacgggca 1260
tagaggatgc aaacgctgtc aggggttcag cctctcaggg gcccctgact gaaccttggg 1320
cagaagacag tcccccagac cagcctcccc cagcttctgc ccgctcctca gtgggggaag 1380
gagagctcca gtatgcatcc ctcagcttcc agatggtgaa gccttgggac tcgcggggac 1440
aggaggccac tgacaccgag tactcggaga tcaagatcca cagatgagaa actgcagaga 1500
ctcaccctga ttgagggatc acagcccctc caggcaaggg agaagtcaga ggctgattct 1560
tgtagaatta acagccctca acgtgatgag ctatgataac actatgaatt atgtgcagag 1620
tgaaaagcac acaggcttta gagtcaaagt atctcaaacc tgaatccaca ctgtgccctc 1680
ccttttattt ttttaactaa aagacagaca aattcctaaa aaaaaaaaaa aaaaaaa 1737
<210> 66
<211> 4186
<212> DNA
<213> Homo sapiens
<400> 66
gtcagaagct atatccagct gctggcagag ttcctgtcaa gggatcaagt cttccaacag 60
aatggttatg gtttaactca gcagaatttg ttgaacaact acgacatgct ggggatcatg 120
gcatggaatg caacttgcaa aaactggctg gcagcagagg ctgccctgga aaagtactac 180
ctttccattt tttatgggat tgagttcgtt gtgggagtcc ttggaaatac cattgttgtt 240
tacggctaca tcttctctct gaagaactgg aacagcagta atatttatct ctttaacctc 300
tctgtctctg acttagcttt tctgtgcacc ctccccatgc tgataaggag ttatgccaat 360
ggaaactgga tatatggaga cgtgctctgc ataagcaacc gatatgtgct tcatgccaac 420
ctctatacca gcattctctt tctcactttt atcagcatag atcgatactt gataattaag 480
tatcctttcc gagaacacct tctgcaaaag aaagagtttg ctattttaat ctccttggcc 540
atttgggttt tagtaacctt agagttacta cccatacttc cccttataaa tcctgttata 600
actgacaatg gcaccacctg taatgatttt gcaagttctg gagaccccaa ctacaacctc 660
atttacagca tgtgtctaac actgttgggg ttccttattc ctctttttgt gatgtgtttc 720
ttttattaca agattgctct cttcctaaag cagaggaata ggcaggttgc tactgctctg 780
ccccttgaaa agcctctcaa cttggtcatc atggcagtgg taatcttctc tgtgcttttt 840
acaccctatc acgtcatgcg gaatgtgagg atcgcttcac gcctggggag ttggaagcag 900
tatcagtgca ctcaggtcgt catcaactcc ttttacattg tgacacggcc tttggccttt 960
ctgaacagtg tcatcaaccc tgtcttctat tttcttttgg gagatcactt cagggacatg 1020
ctgatgaatc aactgagaca caacttcaaa tcccttacat cctttagcag atgggctcat 1080
gaactcctac tttcattcag agaaaagtga ggggcttgtg aaacagattg ttctacagat 1140
gaatctgtaa gccagttaca gtttgcctta actcatagac atcaatcaga gagtgtcaca 1200
gatttaacct tgatctaaag acaagttgta cccagagtat gtgaaaagaa tgggacgaca 1260
agaatgtact ggtttcttcc tctaagaatt gaaaggagtt gaactgcctt atgtttgggc 1320
atgtaactcc aaaatactag gtagtataag gctttctcaa tcagtgcaaa aatggaagat 1380
atataaagca acaagttgtc tgcatttgat cactggtcag attgtaaaaa aaaaaaaaat 1440
tgttttggca acattctcta tgttattctt attcacatga tcctagaact ttatgtgaga 1500
actgaatagc agaagatata ttattaaata gtttttggaa gttgtgctgt taagcaaatg 1560
taaagtcaac agtaacaatg attaagaaag gaatataatg agttcaaaga tatctatctg 1620
atatattttt tatattcatc atgaatcggg gtagtcttgt aatttatcta acctttttgt 1680
tgtatgggtt tatagtggaa agaatcttaa tttaaataaa aagaacctga agagataatt 1740
caacaaaagt agagaatatg tttgagcttg tcagagaatt taagtatcaa aatactagag 1800
agatacacca aggatatttg aataaaaaaa aaatttgtag aacacaaaat gcctatcagg 1860
aaacccaaag caaaacagaa caaaaagtga atacatcgtt ttaaatgatg attttgccat 1920
ctggtatttt attatcataa tttgaccacc agtgcatgaa aatatattaa agttcattag 1980
ccttctgctc ttgatttaat agtgaacttt aaaatatatt aatatcataa accagcaaat 2040
aaggagaaat aaactgataa tactagattc attgggatag ttttcccttt tggagggaaa 2100
gtcacaattt ttctccatga tcccccattt tttgtaaaca ctggaataat ttacaaggat 2160
aactttattg tagcgagagc aaatcacatc tggagtgagc cttgttttca tgcaacatta 2220
ccataagacc attggagtaa atgtttcaaa caaaatgtac ttcatgaaat tatagaacat 2280
aaaaatattt atgtgcatat taacctgtat tatcccagga gggttaatga ggccccattt 2340
cctgcacaaa acaaatgtag gggaaaaaat gggtgctgca ttagcttttt aaagtcaaac 2400
aactatcaca taataattcc ttgatatgca acataaagta cctatggcca catatctaag 2460
ttcctttcct tgatgtcatt agctataagg agtgagtaat gtgaaggaca aaataagcat 2520
tatgaataca gagacataaa attccactgt cccttccttt tctgaaatac tctgggaggt 2580
attctgatat ttttaaatcc cccaattttc ccagttgata tctctagact tcaagcaact 2640
gaaatattat aaaaatgcat tagtcacaaa agatttattt tcttacatca caccaggctt 2700
taagatattt tctgccatgc cttgccttta gtatcaatat tttaaaaatt tcactgtaat 2760
tttataactg cctaataaca aactgaaaac agaacttctg agtttcctta tcagaaaggg 2820
ccacagaaaa ggccttaaga aagaaagatt cacttacttc tgcaaacttg gcaatccgta 2880
atttaacttt aatttgtatt ttatgcatga attttacttg taaagacaaa attaaatttg 2940
cttcccctac atcccaactc caagaagtca caggaataga ctctttctaa tagtgcagtg 3000
aaatattttt tcaaaccata aactcacata tatatatata tatatatata tatatatata 3060
tatatatgta ccttgtaaac aagaggttaa gaaattttat agcacatttt aaaattattt 3120
tcttcctcaa atctatcatg tggtaactta atctttaaca gactttaggg ccctaaacta 3180
aaattataag agctatttca tttgcttgtt gtactgggta attgtaagaa tcacaaacaa 3240
taaatcatga aaatcctttc tgggtttgtg gtttctaaag gaaataatat tgagcttttg 3300
tattttgtct tttaattggc tccctggtat cttcagaatg atgtctagat tcttcagtct 3360
ggacccacct actcttctca cattatctcc catcactgtt gtcacaaacc ataccctata 3420
gctaaagatt gctactttag tttattacat tcagaacttt cttcactttg ttcacctgtt 3480
gcccatcttt gttctatcat acctgaatgg tataataatt ctaaacaact ttcaaggttc 3540
atctcatctg tcattctttg ttgaagcttg cccttatatc ctctcttccc caaacctaaa 3600
agtaaaactt tctaccactg gggcttcaga tacttttaat actacttatt tgaatttcat 3660
tatttttatt atagtttatt attgtcttca tagctgagta ctcttaaaat tactgtttat 3720
tataagtgaa tgtcttacag aacaaactca aagtcaatgc ttcttttgca tgtgaataat 3780
caagctattt ttttgtcatc attactttag taagtaacat tattttatat gaagaataga 3840
gtgtatatac ataaacccat gtgccagctg ccattgcact gcctcacatt ttcctttaga 3900
tgtttgagca tagttttaat gactgtttga aatctctgtc tcctagttcc aaatatgggt 3960
catcttggag ttggtcttca ttggtgcctt ttctcttcag tatgagtcat aattttcctg 4020
tttctctata tgcctagtaa attagaattt tattctagat gatgaataat gtgtggcaga 4080
gattctggat tctgttacat tccatcaaag agtattgata ttttgtatat acatttacaa 4140
atgtacatgt acacaataat aaaaataatt tttttctcag aaaaaa 4186
<210> 67
<211> 3333
<212> DNA
<213> Homo sapiens
<400> 67
gtgcaacttt ccgaagcctc taggtcattg tggtgccttg tagctgtccc gggagccctc 60
agcagcagtt ggagctggtg cacaggaagg atgaggaaga ccaggctctg ggggctgctg 120
tggatgctct ttgtctcaga actccgagct gcaactaaat taactgagga aaagtatgaa 180
ctgaaagagg ggcagaccct ggatgtgaaa tgtgactaca cgctagagaa gtttgccagc 240
agccagaaag cttggcagat aataagggac ggagagatgc ccaagaccct ggcatgcaca 300
gagaggcctt caaagaattc ccatccagtc caagtgggga ggatcatact agaagactac 360
catgatcatg gtttactgcg cgtccgaatg gtcaaccttc aagtggaaga ttctggactg 420
tatcagtgtg tgatctacca gcctcccaag gagcctcaca tgctgttcga tcgcatccgc 480
ttggtggtga ccaagggttt ttcagggacc cctggctcca atgagaattc tacccagaat 540
gtgtataaga ttcctcctac caccactaag gccttgtgcc cactctatac cagccccaga 600
actgtgaccc aagctccacc caagtcaact gccgatgtct ccactcctga ctctgaaatc 660
aaccttacaa atgtgacaga tatcatcagg gttccggtgt tcaacattgt cattctcctg 720
gctggtggat tcctgagtaa gagcctggtc ttctctgtcc tgtttgctgt cacgctgagg 780
tcatttgtac cctaggccca cgaacccacg agaatgtcct ctgacttcca gccacatcca 840
tctggcagtt gtgccaaggg aggagggagg aggtaaaagg cagggagtta ataacatgaa 900
ttaaatctgt aatcaccggc tatttctaaa gtcagcgtct caccttcctg cccactgccc 960
tcgttcctct aataatcttg ggtgggcatt tgtgcctcag aaaagaagtt acagccccaa 1020
acatgcttgg tccttcattc caccagccac ttggggttgg catgaaatac agacagctca 1080
atgcttttca ccgtaattct cttgtggggg ctgtgacatg cagaaggcac acctgatact 1140
tctcctgctc agttttgccc tggaccatac aattttggcc tgacctggac agagctccca 1200
ctacagaagc atcctgctcg ccccatgctg ggacttcctc tttctagcat cagacacttg 1260
ggtttcatgc ttatgtgtgg ttctttccaa cactcccaga aaagggtgtt gaagattgtg 1320
gaacctggag aaataagaca tcgtggtgag aaagtgcatc cttctcagag aaaagagtta 1380
aactgagtat cttcttctgg ggaaatactg gcaggccgag atgggatcca taggagagca 1440
acaacagacc atgtcagaca tcctgtgtgc atttatcgct ggatcctgaa aatagccccg 1500
tgaaggcaga aatgtatgtg actagaacga ggccacatga ataagccact gcccactggc 1560
aggagtgaaa actgaagcgc tccttacctg aaggacccca aaaccatata gaatagaata 1620
accaggagtt ccgcctgtgt ctaaatgcct cttttcctgt atcacacaag ggtcagggat 1680
ggtggagtaa aagctctccc cctgggaggc ttctggaggc tgtccccatg tgcttgccta 1740
gttccccact ctgccctcct cctcttctct cagtctgctc ctggaacacc tgcctcagtt 1800
tccatgctct ctccagtgcc ctccccggtg aagcaggtag gtgttcaggc caccacagag 1860
acaatctctg tgggagattg tcttgcaatc tcccacagat ttcaatcagg attttgttat 1920
ttcctacttt gagctttaaa gggaaatggg cctcatgggt ggggaaagga tggtgggtcc 1980
ttccagccca atttagtgat gcccagggca gatattatcc tcagttccca agagcaatca 2040
tacttttcca cacataccgt gtgtctcatg ttaggtaaat gtatttttac aatgagcacc 2100
acttctgtgg aaaaagttcc ctgcacgggg aggtccagct tccagactgc tccatcgcat 2160
aaggacttcc ccattcccct aaatgctgct ctgtcagaac ctgcccaggt aatggtaatg 2220
accctagaga gatgatttct gaaccgcaat tttgagccca ttagaaggtg tgtggtgggc 2280
atttatttca tcctgatgct ctggtgagaa tctttgcaga cgcactagat ccagaagctg 2340
ttaatcttgg tgcatttatt ttcctaccta aaagaaccaa gcagctcaga ggcagtgact 2400
gtacaggatg cagtgtttat aataatgctg agcttgctgg tctggaaccc cacactttag 2460
caatcccagc attgttcctg tttatgaagt tgacaaagtg accagggcaa gggggtatta 2520
tcattaaata cactctagga gaggcagaac acatgagggc aatgtttttc agaggtcttt 2580
aggccaccgc atcagattct cctggagcat aaagcaaatg ctttatgagt ccagggcccc 2640
tgcagaccta ctgtatacta gtatacagct ccctcttagt ggatctcaag cttgtttcca 2700
aaaagtcatt acactcctta ccaaagccca tgacacattc atacagattc atccagacat 2760
aacccactgc atggtccagt gcatgcttgt gtgcttaact tattatagat caagtgttat 2820
ttaagtccaa catattaaac gtgactgaaa tattatatgc actaaatcgg aagacaaatg 2880
gccgtgctgg atactctccc atttgcactt acaggccacg ccatgctcca tcctccccat 2940
cctgcctggg aacctgacca atgtggctaa accagcaggc tccctggctg ccagcttctg 3000
gctggttgag ccaatgggaa gcatgagagg agagccgagg gtggggagac agtcagatca 3060
gggtttctgt cctcagggct ccctccctgg caggtggtgg caggagtggc tgcattcccc 3120
tctgaaggct ccttcaagcc tctcagcaaa cagctcccat ctccaagtcc agccacctgt 3180
tccatcctct cctctgtagg cccagcagtg ggaatgaccc accactattg ccagcctcag 3240
catactgaag caccccttac tggattccct aaattctatg cacatgttta ttaaatgctc 3300
ctcaattacc cagttaaaaa aaaaaaaaaa aaa 3333
<210> 68
<211> 1602
<212> DNA
<213> Homo sapiens
<400> 68
acagagggtg gagcagccca tgtggtagga aatggcccag cttggctctg ccttctgcag 60
tgtgagtaac acactgaagc cagaagctgt gggctgtggg gaagtggctg catcgccacc 120
caagggaccc tggactttgc cagacgtcag ggttgagagg agccactagc accatcccag 180
agctgtcagc accggcctca gcccaggcgg ctctctccct gagcttcctg taccctgacc 240
ctctccagcc tcagacctga gacagggctg gacaaggaag cagagagcag aagaaaagca 300
gaagcgaagc tcagatctgc tgggaggaga ttacattttg tcccctcctg gggtcttgca 360
cagtggcagg tgacattcgt gttacaggaa tgactgccag ggcctgggcc tcgtggcggt 420
cttcagctct gctcctcctg cttgtcccag gctattttcc tctgagccac cccatgaccg 480
tggcgggccc cgtgggggga tccctgagtg tgcagtgtcg ctatgagaag gaacacagga 540
ccctcaacaa attctggtgc agaccaccac agattctccg atgtgacaag attgtggaga 600
ccaaagggtc agcagggaaa aggaatggcc gagtgtccat cagggacagt cctgcaaacc 660
tcagcttcac agtgaccctg gagaatctca cagaggagga cgcaggcacc tactggtgtg 720
gggtggatac accgtggctc cgagactttc atgatcccat tgtcgaggtt gaggtgtccg 780
tgttcccggc cgggacgacc acagcctcca gcccccagag ctccatgggc acctcaggtc 840
ctcccacgaa gctgcccgtg cacacctggc ccagcgtgac cagaaaggac agccccgaac 900
ccagcccaca ccctggctcc ctgttcagca atgtccgctt cctgctcctg gtcctcttgg 960
agctgcccct gctcctgagc atgctgggtg ccgtcctctg ggtgaacaga cctcagagaa 1020
gctctagaag caggcagaat tggcccaagg gtgagaacca gtagcatctg ctgtccatca 1080
aggccctgtg ctgcaacaga gcccctctgg gggactggaa tgacctcctg accactccct 1140
cccgggctgc tctctccaca tctcctggaa tcctttgtga gcctccttca gccttttccc 1200
tgtgcccgat cctcatgtgt cacatgtgaa cctgacggac atggacgccc tgagctgtga 1260
gtccacgtct catgtgcacg ccccggccag ctaagcctcg ggccgtcagc aatacctctg 1320
agtgcccgga tgccctccct gcacccttcc atttctccag gagcctggca ctgcttcctc 1380
caccgttttc acagggagaa gcaggtctag gactcccctg cacctttgcc accataatgg 1440
cccacactcc ctgggtccag gagtgtagaa tatgcggctg cttccatttg ctgagtgtgt 1500
cgattcaatg atgctttcaa actttaataa atgacaatgt gtaggtttgg gatgtatcag 1560
gcccactcag tcagacctga gtgagaaaaa aaaaaaaaaa aa 1602
<210> 69
<211> 1619
<212> DNA
<213> Homo sapiens
<400> 69
ggctcatttg cagacatatg ggtgattggt acagtaggtt tataaacaga agtttaaact 60
tgtaagctta agcttccgtt tataaacaga agtttaaaat tataggtcct gtttaacatt 120
cagctctgtt aactcactca tctttttgtg tttttacact ttgtcaagat ttctttacat 180
attcatcaat gtctgaagaa gttacttatg cagatcttca attccagaac tccagtgaga 240
tggaaaaaat cccagaaatt ggcaaatttg gggaaaaagc acctccagct ccctctcatg 300
tatggcgtcc agcagccttg tttctgactc ttctgtgcct tctgttgctc attggattgg 360
gagtcttggc aagcatgttt cacgtaactt tgaagataga aatgaaaaaa atgaacaaac 420
tacaaaacat cagtgaagag ctccagagaa atatttctct acaactgatg agtaacatga 480
atatctccaa caagatcagg aacctctcca ccacactgca aacaatagcc accaaattat 540
gtcgtgagct atatagcaaa gaacaagagc acaaatgtaa gccttgtcca aggagatgga 600
tttggcataa ggacagctgt tatttcctaa gtgatgatgt ccaaacatgg caggagagta 660
aaatggcctg tgctgctcag aatgccagcc tgttgaagat aaacaacaaa aatgcattgg 720
aatttataaa atcccagagt agatcatatg actattggct gggattatct cctgaagaag 780
attccactcg tggtatgaga gtggataata taatcaactc ctctgcctgg gttataagaa 840
acgcacctga cttaaataac atgtattgtg gatatataaa tagactatat gttcaatatt 900
atcactgcac ttataaaaaa agaatgatat gtgagaagat ggccaatcca gtgcagcttg 960
gttctacata ttttagggag gcatgaggca tcaatcaaat acatttaagg agtgtagggg 1020
gtgggggttc taggctatag gtaaatttaa atattttctg gttgacaatt agttgagttt 1080
gtctgaagac ctgggatttt atcatgcaga tgaaacatcc aggtagcaag cttcagagag 1140
aatagactgt gaatgttaat gccagagagg tataatgaag catgtcccac ctcccacttt 1200
ccatcatggc ctgaaccctg gaggaagagg aagtccattc agatagttgt ggggggcctt 1260
cgaattttca ttttcattta cgttcttccc cttctggcca agatttgcca gaggcaacat 1320
caaaaaccag caaattttaa ttttgtccca cagcgttgct agggtggcat ggctccccat 1380
ctcgggtcca tcctatactt ccatgggact ccctatggct gaaggcctta tgagtcaaag 1440
gacttatagc caattgattg ttctaggcca ggtaagaatg gatatggaca tgcatttatt 1500
acctcttaaa attattattt taagtaaaag ccaataaaca aaaacgaaaa ggcaaaaaaa 1560
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa 1619
<210> 70
<211> 1458
<212> DNA
<213> Homo sapiens
<400> 70
ggaggagacg ccatgacccc caccctcgca gccctgctct gcctagggct gagtctgggc 60
cccaggaccc acgtgcaggc agggcccttc cccaaaccca ccctctgggc tgagccaggc 120
tctgtgatca gctgggggag ccccgtgacc atctggtgtc aggggagcct ggaggcccag 180
gagtaccgac tggataaaga gggaagccca gagccctggg acagaaataa cccactggaa 240
cccaagaaca aggccagatt ctccatccca tccataacag agcaccatgc ggggagatac 300
cgctgccact attacagctc tgcaggctgg tcagagccca gcgaccccct ggagctggtg 360
atgacaggag cctatagcaa acccaccctc tcagccctgc ccagccctgt ggtggcctca 420
ggggggaata tgaccctcca atgtggctca cagaagggat atcaccattt tgttctgatg 480
aaggaaggag aacaccagct cccccggacc ctggactcac agcagctcca cagtgggggg 540
ttccaggccc tgttccctgt gggccccgtg aaccccagcc acaggtggag gttcacatgc 600
tattactatt atatgaacac cccccgggtg tggtcccacc ccagtgaccc cctggagatt 660
ctgccctcag gcgtgtctag gaagccctcc ctcctgaccc tgcagggccc tgtcctggcc 720
cctgggcaga gcctgaccct ccagtgtggc tctgatgtcg gctacgacag atttgttctg 780
tataaggagg gggaacgtga cttcctccag cgccctggcc agcagcccca ggctgggctc 840
tcccaggcca acttcaccct gggccctgtg agcccctccc acgggggcca gtacaggtgc 900
tatggtgcac acaacctctc ctccgagtgg tcggccccca gcgaccccct gaacatcctg 960
atggcaggac agatctatga caccgtctcc ctgtcagcac agccgggccc cacagtggcc 1020
tcaggagaga acgtgaccct gctgtgtcag tcatggtggc agtttgacac tttccttctg 1080
accaaagaag gggcagccca tcccccactg cgtctgagat caatgtacgg agctcataag 1140
taccaggctg aattccccat gagtcctgtg acctcagccc acgcggggac ctacaggtgc 1200
tacggctcat acagctccaa cccccacctg ctgtctttcc ccagtgagcc cctggaactc 1260
atggtctcag gacactctgg aggctccagc ctcccaccca cagggccgcc ctccacacct 1320
gcctcacacg ccaaggatta cacagtggag aatctcatcc gcatgggcat ggcaggcttg 1380
gtcctggtgt tcctcgggat tctgttattt gaggctcagc acagccagag aaacccccaa 1440
gatgcagccg ggaggtga 1458
<210> 71
<211> 2518
<212> DNA
<213> Homo sapiens
<400> 71
ctcatttgtg tgttttctga gtcagcatta gctaaatttt ccagaaggcc atccacaaag 60
tacagcctgg gcgttcaagg gacgtcattc atttccccca gtgaccttga caagtcagaa 120
gcttgaaagc agggaaatcc ggatgtctcg gttatgaagt ggagcagtga gtgtgagcct 180
caacatagtt ccagaactct ccatccggac tagttattga gcatctgcct ctcatatcac 240
cagtggccat ctgaggtgtt tccctggctc tgaaggggta ggcacgatgg ccaggtgctt 300
cagcctggtg ttgcttctca cttccatctg gaccacgagg ctcctggtcc aaggctcttt 360
gcgtgcagaa gagctttcca tccaggtgtc atgcagaatt atggggatca cccttgtgag 420
caaaaaggcg aaccagcagc tgaatttcac agaagctaag gaggcctgta ggctgctggg 480
actaagtttg gccggcaagg accaagttga aacagccttg aaagctagct ttgaaacttg 540
cagctatggc tgggttggag atggattcgt ggtcatctct aggattagcc caaaccccaa 600
gtgtgggaaa aatggggtgg gtgtcctgat ttggaaggtt ccagtgagcc gacagtttgc 660
agcctattgt tacaactcat ctgatacttg gactaactcg tgcattccag aaattatcac 720
caccaaagat cccatattca acactcaaac tgcaacacaa acaacagaat ttattgtcag 780
tgacagtacc tactcggtgg catcccctta ctctacaata cctgccccta ctactactcc 840
tcctgctcca gcttccactt ctattccacg gagaaaaaaa ttgatttgtg tcacagaagt 900
ttttatggaa actagcacca tgtctacaga aactgaacca tttgttgaaa ataaagcagc 960
attcaagaat gaagctgctg ggtttggagg tgtccccacg gctctgctag tgcttgctct 1020
cctcttcttt ggtgctgcag ctggtcttgg attttgctat gtcaaaaggt atgtgaaggc 1080
cttccctttt acaaacaaga atcagcagaa ggaaatgatc gaaaccaaag tagtaaagga 1140
ggagaaggcc aatgatagca accctaatga ggaatcaaag aaaactgata aaaacccaga 1200
agagtccaag agtccaagca aaactaccgt gcgatgcctg gaagctgaag tttagatgag 1260
acagaaatga ggagacacac ctgaggctgg tttctttcat gctccttacc ctgccccagc 1320
tggggaaatc aaaagggcca aagaaccaaa gaagaaagtc cacccttggt tcctaactgg 1380
aatcagctca ggactgccat tggactatgg agtgcaccaa agagaatgcc cttctcctta 1440
ttgtaaccct gtctggatcc tatcctccta cctccaaagc ttcccacggc ctttctagcc 1500
tggctatgtc ctaataatat cccactggga gaaaggagtt ttgcaaagtg caaggaccta 1560
aaacatctca tcagtatcca gtggtaaaaa ggcctcctgg ctgtctgagg ctaggtgggt 1620
tgaaagccaa ggagtcactg agaccaaggc tttctctact gattccgcag ctcagaccct 1680
ttcttcagct ctgaaagaga aacacgtatc ccacctgaca tgtccttctg agcccggtaa 1740
gagcaaaaga atggcagaaa agtttagccc ctgaaagcca tggagattct cataacttga 1800
gacctaatct ctgtaaagct aaaataaaga aatagaacaa ggctgaggat acgacagtac 1860
actgtcagca gggactgtaa acacagacag ggtcaaagtg ttttctctga acacattgag 1920
ttggaatcac tgtttagaac acacacactt actttttctg gtctctacca ctgctgatat 1980
tttctctagg aaatatactt ttacaagtaa caaaaataaa aactcttata aatttctatt 2040
tttatctgag ttacagaaat gattactaag gaagattact cagtaatttg tttaaaaagt 2100
aataaaattc aacaaacatt tgctgaatag ctactatatg tcaagtgctg tgcaaggtat 2160
tacactctgt aattgaatat tattcctcaa aaaattgcac atagtagaac gctatctggg 2220
aagctatttt tttcagtttt gatatttcta gcttatctac ttccaaacta atttttattt 2280
ttgctgagac taatcttatt cattttctct aatatggcaa ccattataac cttaatttat 2340
tattaacata cctaagaagt acattgttac ctctatatac caaagcacat tttaaaagtg 2400
ccattaacaa atgtatcact agccctcctt tttccaacaa gaagggactg agagatgcag 2460
aaatatttgt gacaaaaaat taaagcattt agaaaacttc aaaaaaaaaa aaaaaaaa 2518
<210> 72
<211> 1568
<212> DNA
<213> Homo sapiens
<400> 72
gcgccaggga ggcgtcgccc tgccgcgtcg gagctgcttc ctgggcgccg tgggcgcgga 60
ctgcgcgggc tgcgcgggtg ccgaggagcg cgaggcgcgg ggaaggcgca cctggggtgg 120
ccctggcgtg cgggcggcga catggaggac ggcgtgctca aggagggctt cctggtcaag 180
aggggccaca ttgtccacaa ctggaaggcg cgatggttca tccttcggca gaacacgctg 240
gtgtactaca agcttgaggg gggtcggaga gtgacccctc ccaagggccg gatcctcctg 300
gatggctgca ccatcacctg cccctgcctg gagtatgaaa accgaccgct cctcattaag 360
ctgaagactc aaacatccac ggagtacttc ctggaggcct gttctcgaga ggagcgggat 420
gcctgggcct ttgagatcac cggggctatt catgcagggc agccggggaa ggtccagcag 480
ctgcacagcc tgagaaactc cttcaagctg cccccgcaca tcagcctgca tcgcattgtg 540
gacaagatgc acgatagcaa caccggaatc cgttcaagcc ccaacatgga gcagggaagc 600
acctataaaa agaccttcct cggctcctcc ctggtggact ggctcatctc caacagcttc 660
acggccagcc gtctggaggc ggtgaccctg gcctccatgc tcatggagga gaacttcctc 720
aggcctgtgg gtgtccgaag catgggagcc attcgctctg gggatctggc cgagcagttc 780
ctggatgact ccacagccct gtacactttt gctgagagct acaaaaagaa gataagcccc 840
aaggaagaaa ttagcctgag cactgtggag ttaagtggca cggtggtgaa acaaggctac 900
ctggccaagc agggacacaa gaggaaaaac tggaaggtgc gtcgctttgt tctaaggaag 960
gatccagctt tcctgcatta ctatgaccct tccaaagaag agaacaggcc agtgggtggg 1020
ttttctcttc gtggttcact cgtgtctgct ctggaagata atggcgttcc cactggggtt 1080
aaagggaatg tccagggaaa cctcttcaaa gtgattacta aggatgacac acactattac 1140
attcaggcca gcagcaaggc tgagcgagcc gagtggattg aagctatcaa aaagctaaca 1200
tgacaaggac ctgagggaac caggattcct ccctcctacc agatgacaca gacaagagtt 1260
cctggagaat gggagtgtta agacttttga cttctttgta agttttgtac tgctttggag 1320
agtgaatgct gccaagagtt cctcagatta caaacagcag tggtgccatt tccttcccca 1380
tcttcatgtt acaaacctgg aaaggctaga acagccatta ggcgtcagca tcttgacttt 1440
tccccagcat cacaaacagc catttcctcg ggcaccaaag taggttccct ttgttggaac 1500
aattacactg gccatgccat aatgttgaat aaaactctct tcttatgagg ttcaaaaaaa 1560
aaaaaaaa 1568
<210> 73
<211> 3797
<212> DNA
<213> Homo sapiens
<400> 73
aaccgtcatt ttcctacgcg ccctctgaca tcagccacct tctctgtagc tagtttctct 60
gcacacaact taatccctgg caatgaaaaa tgaacctctc ccccaccctt gctgccgcct 120
ctcgcctcac gcccccagag aagagtttct ccaccaggca gcaggtgaag gtttttttcc 180
aagtcacatg attcaggatt cagggggaga atccttcttg gaacagagat gggcccagaa 240
ctgaatcaga tgaagagaga taaggtgtga tgtggggaag actatataaa gaatggaccc 300
agggctgcag caagcactca acggaatggc ccctcctgga gacacagcca tgcatgtgcc 360
ggcgggctcc gtggccagcc acctggggac cacgagccgc agctatttct atttgaccac 420
agccactctg gctctgtgcc ttgtcttcac ggtggccact attatggtgt tggtcgttca 480
gaggacggac tccattccca actcacctga caacgtcccc ctcaaaggag gaaattgctc 540
agaagacctc ttatgtatcc tgaaaagggc tccattcaag aagtcatggg cctacctcca 600
agtggcaaag catctaaaca aaaccaagtt gtcttggaac aaagatggca ttctccatgg 660
agtcagatat caggatggga atctggtgat ccaattccct ggtttgtact tcatcatttg 720
ccaactgcag tttcttgtac aatgcccaaa taattctgtc gatctgaagt tggagcttct 780
catcaacaag catatcaaaa aacaggccct ggtgacagtg tgtgagtctg gaatgcaaac 840
gaaacacgta taccagaatc tctctcaatt cttgctggat tacctgcagg tcaacaccac 900
catatcagtc aatgtggata cattccagta catagataca agcacctttc ctcttgagaa 960
tgtgttgtcc atcttcttat acagtaattc agactgaaca gtttctcttg gccttcagga 1020
agaaagcgcc tctctaccat acagtatttc atccctccaa acacttgggc aaaaagaaaa 1080
ctttagacca agacaaacta cacagggtat taaatagtat acttctcctt ctgtctcttg 1140
gaaagataca gctccagggt taaaaagaga gtttttagtg aagtatcttt cagatagcag 1200
gcagggaagc aatgtagtgt ggtgggcaga gccccacaca gaatcagaag ggatgaatgg 1260
atgtcccagc ccaacctcta attcactgta tggtcttgat ctatttcttc tgttttgaga 1320
gcctccagtt aaaatggggc tccagtacca gagcagctag caactctgcc ctaatgggaa 1380
atgaagggga gctgggtgtg agtgtttaca ctgtgccctt cacgggatac ttcttttatc 1440
tgcagatggc ctaatactta gttgtccaag tcgcgatcaa ggactctctc acacaggaaa 1500
cttccctata ctggcagata cacttgtgac tgaaccatgc ccagtttatg cctgtctgac 1560
tgtcactctg gcactaggag gctgatcttg tactccatat gaccccaccc ctaggaaccc 1620
ccagggaaaa ccaggctggg acagccccct gttcctgaga tggaaagcac aaatttaata 1680
caccaccaca atggaaaaca agttcaaaga cttttactta cagatcctgg acagaaaggg 1740
cataatgagt ctgaagggca gtcctccttc tctaggttac atgaggcagg aataagaagt 1800
cagacagaga cagcaagaca gttaacaatg taggtaaaga aatagggtgt ggtcactctc 1860
aattcactgg caaatgcctg aatggtctgt ctgaaggaag caacagagaa gtggggaatc 1920
cagtctgcta ggcaggaaag atgcctctaa gttcttgtct ctggccagag gtgtggtata 1980
gaaccagaaa cccatatcaa gggtgactaa gcccggcttc tggtatgaga aattaaactt 2040
gtatacaaaa tggttgccaa ggcaacataa aattataaga attcactata ccttcccctc 2100
cctggaactc aggatccaag tctagaaaat gaaaggactg ggtttgaatt gcttcaaaac 2160
ctcttccatc tcagaagacc agaccctggg aactgagatt ccagacacaa ttttggaagc 2220
tctccaacca aaataaggcc cccctacccc agtatataat tgaagacact agtaacacct 2280
gactgcatct catctcagca gagccagaat atggggacaa ggttcagggt gccctgctga 2340
atggtgtgaa cagcaggatc tcaaggatgt aatggaaaga actaccacac tgaccatcca 2400
gaatctaaga gaccatctgg gtgtttggga aaccatctga cgaggcctga ctctattcca 2460
gttagattga caataattga gcagcaggca tttttcattt ctggtcagga aagcattgtg 2520
cctttagcaa acaatcagtg tgcaacagtg atgtggtcat ctagccaggg aatggctgct 2580
ccatcccctg cataatatat tcctgcttca aacacctctc agaaaaccag ttccgcgagg 2640
gtttttatat ccccacaaag ttgttgagag acaatgatga ccctggaagt ggggaggagg 2700
acttctgaga aacagcaacc tctctcctga ttggggtagc catgagattt ctctagctat 2760
atccaacttg gcatctgtac atcatctttg gaggaacatc ttatttgtgg aaggaccttg 2820
acaagccgtt tgagatggaa tgtaggccct gatgttatgc ttcagtaaaa aaagatggaa 2880
gcttccctgc tataccaaaa catggagcaa aatttgcatt tttctcaaga aggagagaaa 2940
aggagtagga ctccagcaaa gtttgtcaga aggaaagcta gaaaagattt aaaagaaaaa 3000
aagaaagaac aaatcagcag tggtggtatg gatgaaaggg acttgagaga acaaaaatgg 3060
ctaagggaaa attttaagtc atctgctgag cagtgtgctg tgtcaacctc ctcctaggtc 3120
tcctctatga aatatttagt aaagtctaca tttctcttta actctttctg tgagtagatt 3180
ctttgggaga agcaggcatt ggaagaggtg ttgaattcag caagccaaat ggtctgtggt 3240
aaaaaacaaa acagactttg agactcaagg ctaaaaaaac agggaaatgg ctggcatttg 3300
agtcacacac taactgcata ggacaaatga atcttgctta aaccaactca tgcattcttg 3360
aaaaggtata tgcaacccaa ctgtgtgtta actaagcaat ttttttgcca tctcacattc 3420
taactcgaga aagattccat tttcattttt caccaactgt tctctgagca gaggtacctg 3480
acttttgcac tgtgagtggt ttctaatctc agtctctgtc aagcaatgct aagaaagcca 3540
acacctaaag acacaagggg tacatcattt aaatgaataa tgtaaccaaa caaacaaaaa 3600
aagagaataa tcattaataa ctcaactgat agatatgtag ggagtaggca acccaggaag 3660
tttaaaacta aattctgtta ctcttgaggg ttaaccagcc cctgggaatg ttatgagcaa 3720
atgatactcc atgagtaaaa tgatatctat gcaagtaaaa taaataattt atctaactgg 3780
gaaaaaaaaa aaaaaaa 3797
<210> 74
<211> 3952
<212> DNA
<213> Homo sapiens
<400> 74
tgctggcccc cctgggtcca gaggagcctt gccgccctca cctgcgcaga gcctggagcc 60
gacgcgtcac ccccagcgga agcgcctcgc tgcccgggcg tctggcgagg tgtgcgctcc 120
gggtcccagc tccagcgctt cgcggcagtc gcccgcctct ttccgcaagc agggcgggga 180
ctgggcggca tctaccgaga tctgcgattc gaggcgccga ggagccgaag accacagctc 240
agctcagacg gcgccctagg gccgcacaga gggtcgggca gtgccggaga gaggtttgaa 300
agcgccgccg ccaactcgac agcgcgtccc agcgccttga gctcgcttcc tcctgctctc 360
aggaaaaact gaggaaacgc gcctggttcc aggggtcggc ggggaccgtg gagacgctgc 420
cagcatcctc aacagcttgg aaatcccatc accttggttc cctgagactt ggaggactag 480
taggaactga cagctggctg acagaaaact tatccaggga gagaagagac aaaagtgaag 540
tgtgaaattt tgaataatgt tttcagatgc tttgcattca gaatagacct ctgagttggg 600
acccaagctg tcaactgatc ccaaattcct aagttcctga cttgcaggta ttgagttcta 660
acctccgaag atggatgaag gtatggaaat ttcaagtgaa ggaaattcct tgatcaaagc 720
agtccatcag agccggcttc gcctcacaag acttttgcta gaaggcggtg cctacattaa 780
tgagagcaac gaccgtgggg aaaccccttt aatgatcgct tgtaagacca aacatgtcga 840
tcaccagagt gtcagtaaag ccaaaatggt gaaatacctg ttagagaaca atgccgatcc 900
caacatacag gacaaatctg ggaaaacggc tctgatgcat gcttgcttag aaaaagctgg 960
ccctgaagtt gtttccttgc tcctcaagag tggggctgac ctcagcttgc aagaccattc 1020
tagttactca gctcttgttt atgctataaa ttcagaagat acagagaccc tgaaagttct 1080
tcttagtgct tgcaaggcaa aagggaaaga ggtcatcatc atcacaacag caaagttgcc 1140
ctgtgggaag catactacta aacaatactt aaatatgcct cctgtggata tagatgggtg 1200
tcattcccca gctacctgca ccactccttc agaaatagac atcaaaactg cctcatcgcc 1260
actttcacat tcttctgaaa cggaactgac gctttttggc tttaaagatc ttgagcttgc 1320
tggaagcaat gatgatacct gggacccagg ttcccctgtg aggaaacctg cattggcccc 1380
taaggggccc aagctccccc acgctccacc ctgggtcaag agtcccccat tattaatgca 1440
ccagaacaga gtggcttcat tgcaagagga gctccaggat attacaccag aggaagaact 1500
atcctataaa accaatgggc tggcactttc caagcggttc atcactaggc accaaagcat 1560
tgatgtaaaa gacactgcac atttgctaag agcctttgat caggccagct caaggaagat 1620
gtcatatgat gaaataaatt gtcaatctta tctttcagaa ggaaatcagc aatgcattga 1680
agtccctgtt gaccaggacc cagattctaa ccagacaata tttgcttcca ccttaagaag 1740
tatagttcaa aaaagaaact tgggggcaaa tcactacagc tctgattccc agctctcagc 1800
tggccttacc cctccaactt cagaagacgg caaagcactt ataggaaaga aaaagatcct 1860
ctcaccatct ccttcccaat tgtcagagtc caaagaattg ttggagaata tccccccagg 1920
tcccctgagc aggagaaatc atgcagtttt agaaaggcga ggttcaggag ctttcccttt 1980
agatcacagt gttacccaaa ccagacaagg gtttctccca cccttaaatg taaattctca 2040
ccctcccatc tcagatatca atgtcaacaa caagatttgc agccttcttt cttgtggtca 2100
aaaagtgctt atgccaacag ttccgatttt ccctaaagaa ttcaaaagta agaaaatgtt 2160
gttaaggaga caatcattgc aaactgaaca aattaagcaa ttagtaaact tctaggagat 2220
gggtataaaa cacatcttct tcaaatgttt atatcagaga aacaaagaac tagagaagaa 2280
atcttaaatg ttcattcttt taaatctcgt gattggttag tccataatgg ctagatggat 2340
taaaatgtaa tgtgatttgt actaggcgtc atgagcataa aaaataatac atagtttctg 2400
ttaagggaat tctctcaaac aaaaggaaag cgatttttct caatgcttct aatatttaac 2460
aatctccatg tagtccaaat ttgtcattaa aaaaaaatca aagaaagaag gccacgtatg 2520
ttggggtaat ttttaaaaat tttcagattg gctaaatatt ttattaggaa acagttttca 2580
agtcaataat ttttttaaca tttcatgtta ataaatgaga ttgaaatttt ttatgatctc 2640
taaaccataa aagaaaacac cgacagctgt aaaatgttct aagataaaaa aactcgagct 2700
acaaagaaag aatgaactaa ttctttacaa atgttgactg aagatagata aaactctaat 2760
taaaaattta aaaggttaaa cactgtatta gaatgggcaa ctaaaatatt cgtggtgtca 2820
gtttaattag tgtcaaactg gcaagtcaga gttttacaac ctactagtaa tctatgccgg 2880
gtcttgttgt ttgtgcactg tgttttgctt tgctttgttt tggtttttaa acagacttac 2940
ctgtaaagtt atcttacgga attattcttt ctccatatct tttaaggaat tattctttct 3000
ccatatcatc ttttaattcc tgttattagt tttggaagct tatccataag tttccaaaga 3060
caagatgata taaaagttaa aaagcattcc tctttactta tatcaaatta ttcttgtctt 3120
tcaaaaagaa ccaaaaaaaa aaaattcatc atggataaaa actaagcgct tgccttcttt 3180
taaaaagaaa aactgatgat tagattaggt tagctaaaat taatagaggc agtagaaact 3240
taatcacaaa atgtactaaa tatttggcaa tattaaacaa tgccttttta tttctgatat 3300
gtagttatta gacatttata tattaaggat aacttcctta gtgtgacatt ccaatcattt 3360
agtattttag gacctgtgaa taacttccaa caaaattaat gaataccata ttagtattat 3420
aaaatattat aaagtaataa ttatatcatc tatataactt caaagtatga tgtttataca 3480
aagaatcctt atttcagtct agcagcttaa caacaaagga taaatcagac tatacaaaac 3540
ctaagtgtat taatttgatg attgtcacgt acaactttct ttgccttcca agtagaggtg 3600
atcctaacaa ttggcatgat gcttttcttg gtaatttgat ataagcaagt tgtaatgtac 3660
atagtaatta tttaattact gtggctttta ttttaaaaag taattagagg tttttccatt 3720
tcatgtcttg aacaacatta atattaatta cactagaaat attttttgat tcagaactta 3780
gaattgtacc tgatatttat aggtatttaa atgctttctg caagttaaat atcgagaaaa 3840
gtacttgact tcaagttgta aggatacaat ttggaagggt atgtaaatag attagttcat 3900
aaacaaaatg gtatcaataa agattttaaa tatcaaaaaa aaaaaaaaaa aa 3952
<210> 75
<211> 2471
<212> DNA
<213> Homo sapiens
<400> 75
tcagaatcta gaggaagttg acaaaggtgc cacagcagca cagcacagta tgtggtggag 60
agttctcagc ttgctggcat ggttcccctt gcaagaggcc tctctgacta accacacaga 120
aaccatcacc gtggaggaag gccagacgct cactctaaag tgtgtcactt ctctgaggaa 180
gaactcctcc ctccagtggc tgaccccctc agggttcacc atttttttaa atgagtatcc 240
tgctttaaaa aattccaaat accagcttct tcatcactcg gccaatcagc tctccatcac 300
tgtgcctaac gtaaccctgc aagatgaagg cgtgtacaag tgcttacatt acagcgactc 360
tgtaagcaca aaggaagtga aagtgattgt gctggcaact cctttcaagc caatcctgga 420
agcttcagtt atcagaaagc aaaatggaga agaacatgtt gtactcatgt gctccaccat 480
gagaagcaag ccccctccgc agataacctg gctacttggg aatagcatgg aagtgtccgg 540
tggaacgctc catgaatttg aaactgatgg gaagaaatgt aatactacca gcactctcat 600
aatccacact tatggcaaaa attcaacggt ggactgcatt atccgacaca gaggcctgca 660
agggagaaaa ctagtagcac ccttccggtt tgaagatttg gttactgatg aagagacagc 720
ttcagatgct ctggagagaa actctctatc ctctcaagac ccacagcagc ccaccagtac 780
tgtctcagta acggaagatt ctagtacatc ggagattgac aaggaagaga aagaacaaac 840
cactcaagat cctgacttga ccaccgaagc aaatcctcag tatttaggac tggcaagaaa 900
gaaaagtggc atcctgctgc tcacgctggt gtccttcctc attttcatac tcttcatcat 960
agtccagctc ttcatcatga agctgaggaa agcacatgtg atatggaaga aagaaaacga 1020
agtttcagaa cacacactag aaagttacag atcaaggtca aataatgaag aaacatcatc 1080
tgaagagaaa aatggccaat cttcccaccc tatgcgttgc atgaactaca tcacaaagtt 1140
gtactcagaa gcaaaaacaa agaggaagga aaatgtacaa cattcaaaat tagaagaaaa 1200
gcacatccaa gtaccagaga gtattgtgta gtgctctctg caatggaaca tgtgatttca 1260
gggttgccgc agtgtcacct cagtggacca gcctggggga aggagcttaa ttgctgagac 1320
attaataatg acctcttagt gcaatgcaag atggtgtcct cggataatga tctgccccgg 1380
agctagggca gcaacatgag gaccaaacca tgcacataaa gcttgtagtt taaaaaagaa 1440
aagcaaaaaa ataattatgc ctgacactac ttcagagcag gaggattcta cgaagccttg 1500
gggatcaggg tcagtgtgag cagctaacat cctacctcaa atggaacagg attttttgat 1560
gctttgctct aatggaactg tttaaaaaat ttttttttct ttttaatatt ttcttctggt 1620
cacaaaataa agaaatttgg gatgcaaagt acctaaagat ctctgatcct aagaagttac 1680
ttctggccag gcgcggtggc tcatgcctgt aatcctagca ctttgggagg ctgaggtagg 1740
cagatcactt gaggtcagga gttggagacc agcctggcca acatagtgaa accccgtctc 1800
tactaaaaat gcaaaaatta gccaggcgta gtggtgcgca cctgtagtct cagatacttg 1860
ggaggctgag ggtggagaat cgcttgaacc tgggaggtgg agattgcagt gagtcaagat 1920
ctcaccactg cactccagcc tgggcaacag agggagactc tgtctcaaaa aaaaagaagt 1980
tacttccaag acagactttt aagatgtaac cagcacaaag caatgtcagg gaggagtgat 2040
acatgacaat aaatgagtca gatgagcaag aaggccccag aacccatgcc ccaaggcaca 2100
aagaggagct cagggtaggc ccaaagattc gaattcctta gattactaaa tcacatgagc 2160
ggaccttgtc tgtcagataa gatttttacc tggaaattcc atgaccaata catgtgcaaa 2220
agaaaatgat gggttgaatt tactgattat tgacctaatg gatggctttt taaaatgttt 2280
taataaaaag cagaatagat gtttgttttt ctagtggtta taccaagtta tacttcctgt 2340
tttcacgtgt gaaagtaaca tgggacatgc ctttcttttc cgatcagttt atttaagcta 2400
tacagcaaac tttggcattt atgtggagca tttctcattg ttggaatctg aataaaccaa 2460
ttacaaaata a 2471
<210> 76
<211> 1595
<212> DNA
<213> Homo sapiens
<400> 76
gagtgagtga gagggcagag gaaatactca atctgtgcca ctcactgcct tgagcctgct 60
tcctcactcc aggactgcca gaggaagcaa tcaccaaaat gaagactgct ttaattttgc 120
tcagcatttt gggaatggcc tgtgctttct caatgaaaaa tttgcatcga agagtcaaaa 180
tagaggattc tgaagaaaat ggggtcttta agtacaggcc acgatattat ctttacaagc 240
atgcctactt ttatcctcat ttaaaacgat ttccagttca gggcagtagt gactcatccg 300
aagaaaatgg agatgacagt tcagaagagg aggaggaaga agaggagact tcaaatgaag 360
gagaaaacaa tgaagaatcg aatgaagatg aagactctga ggctgagaat accacacttt 420
ctgctacaac actgggctat ggagaggacg ccacgcctgg cacagggtat acagggttag 480
ctgcaatcca gcttcccaag aaggctgggg atataacaaa taaagctaca aaagagaagg 540
aaagtgatga agaagaagag gaggaagagg aaggaaatga aaacgaagaa agcgaagcag 600
aagtggatga aaacgaacaa ggcataaacg gcaccagtac caacagcaca gaggcagaaa 660
acggcaacgg cagcagcgga ggagacaatg gagaagaagg ggaagaagaa agtgtcactg 720
gagccaatgc agaagacacc acagagaccg gaaggcaggg caagggcacc tcgaagacaa 780
caacctctcc aaatggtggg tttgaaccta caaccccacc acaagtctat agaaccactt 840
ccccaccttt tgggaaaacc accaccgttg aatacgaggg ggagtacgaa tacacgggcg 900
ccaatgaata cgacaatgga tatgaaatct atgaaagtga gaacggggaa cctcgtgggg 960
acaattaccg agcctatgaa gatgagtaca gctactttaa aggacaaggc tacgatggct 1020
atgatggtca gaattactac caccaccagt gaagctccag cctgggatga attcatccat 1080
tctggctttg catccggcta ccattttcga agttcaactc aggaaggtgc aatataacaa 1140
atgtgcatat tataatgagg aatggtacta ccgttccaga ttttctgtaa ttgcttctgc 1200
aaagtaatag gcttcttgtc cctttttttt ctggcatgtt atggaatgat cattgtaaat 1260
caggaccatt tatcaagcag tacaccaact cataagatca aatttcattg aatggtttga 1320
ggttgtagct ctataaatag tagtttttaa catgcctgta gtattgctaa ctgcaaaaac 1380
atactctttg tacaagaagt gcttctaaga atttcattga cattaatgac actgtataca 1440
ataaatgtgt agtttcttaa tcgcactacc tatgcaacac tgtgtattag gtttatcatc 1500
ctcatgtatt tttatgtgac ctgtatgtat attctaatct acgagtttta tcacaaataa 1560
aaatgcaatc cttcaaatgt gttataatta aaaaa 1595
<210> 77
<211> 3060
<212> DNA
<213> Homo sapiens
<400> 77
cagcatcgcc ttttcctccc gtttctcctt ccactcccag ctccacatcc tcctcctatt 60
ctcccctctc ccctcttcaa acccccacct tccagttccc tcacctcccc tttcggctgg 120
tcccctgggg cttgcagcaa gagggagaga gagctcctga caggattgat ggtccttccc 180
caccctgtcc tctcatccgc tccctcccca gcaggcacag acatccccct acaaaaggca 240
ggagcccagg ctgtgtggaa acagctgctc tcagacgcct ttccatttgc tctctgctgg 300
ctaggctggg ctgtgcctct gctccctctt cctctagctg agagtgggca cctggggtac 360
cgggcccccc cacctcattc cccatgaatg ctgtgggaag tcctgagggg caggagctgc 420
aaaagctggg gagtggagcc tgggacaacc ccgcctacag tggtccccct tccccacacg 480
ggacgctgag agtctgcacc atctccagca cggggcctct ccagccccaa cccaagaagc 540
ctgaagatga accccaggag acggcataca ggacccaggt gtccagctgc tgcctccata 600
tctgtcaagg catcagagga ctttggggaa caaccctgac tgagaacaca gctgagaacc 660
gggaacttta tatcaagacc accctgaggg agctgttggt atatattgtg ttcctggtgg 720
acatctgtct actgacctat ggaatgacaa gctccagtgc ttattactac accaaagtga 780
tgtctgagct cttcttacat actccatcag acactggagt ctcctttcag gccatcagca 840
gcatggcgga cttctgggat tttgcccagg gcccactact ggacagtttg tattggacca 900
aatggtacaa caaccagagc ctgggccatg gctcccactc cttcatctac tatgagaaca 960
tgctgctggg ggttccgagg ctgcggcagc taaaggtccg caatgactcc tgtgtggtgc 1020
atgaagactt ccgggaggac attctgagct gctatgatgt ctactctcca gacaaagaag 1080
aacaactccc ctttgggccc ttcaatggca cagcgtggac ataccactcg caggatgagt 1140
tggggggctt ctcccactgg ggcaggctca caagctacag cggaggtggc tactacctgg 1200
accttccagg atcccgacag ggtagtgcag aggctctccg ggcccttcag gaggggctgt 1260
ggctggacag gggcactcga gtggtgttca tcgacttctc agtctacaat gccaatatca 1320
atcttttctg tgtcctgagg ctggtggtgg agtttccagc tacaggaggt gccatcccat 1380
cctggcaaat ccgcacagtc aagctgatcc gctatgtcag caactgggac ttctttatcg 1440
ttggctgtga ggtcatcttc tgcgtcttca tcttctacta tgtggtggaa gagatcctgg 1500
agctccacat tcaccggctt cgctacctca gcagcatctg gaacatactg gacctggtgg 1560
tcatcttgct ctccattgtg gctgtgggct tccacatatt ccgaaccctc gaggtgaatc 1620
ggctcatggg gaagctcctg cagcagccaa acacgtatgc agactttgag ttcctcgcct 1680
tctggcagac acagtacaac aacatgaatg ctgtcaacct cttcttcgcc tggatcaaga 1740
tattcaagta catcagcttc aacaaaacca tgacccagct ctcctccacg ctggcccgct 1800
gtgccaagga catcctgggc ttcgccgtca tgttcttcat tgttttcttc gcctatgccc 1860
aactcggcta cctgcttttc gggacccaag tggaaaactt tagcactttc atcaagtgca 1920
ttttcactca gttccggata atcctcgggg actttgacta caatgctatc gacaatgcca 1980
accgcatcct gggccctgcc tactttgtca cctatgtctt cttcgtcttc ttcgtgctcc 2040
tgaacatgtt cctggccatc atcaatgaca catattcaga ggtcaaggag gagctggctg 2100
gacagaagga tgagctgcaa ctttctgacc tcctgaaaca gggctacaac aagaccctac 2160
taagactgcg tctgaggaag gagagggttt cggatgtgca gaaggtcctg cagggtgggg 2220
agcaggagat ccagtttgag gatttcacca acaccttaag ggaactggga cacgcagagc 2280
atgaaatcac tgagctcacg gccaccttca ccaagtttga cagagatggg aatcgtattc 2340
tggatgagaa ggaacaggaa aaaatgcgac aggacctgga ggaagagagg gtggccctca 2400
acactgagat tgagaaacta ggccgatcta ttgtgagcag cccacaaggc aaatcgggtc 2460
cagaggctgc cagagcagga ggctgggttt caggagaaga attctacatg ctcacaagga 2520
gagttctgca gctggagact gtcctggaag gagtagtgtc ccagattgat gctgtaggct 2580
caaagctgaa aatgctggag aggaaggggt ggctggctcc ctccccaggc gtgaaggaac 2640
aagctatttg gaagcacccg cagccagccc cagctgtgac cccagacccc tggggagtcc 2700
agggtgggca ggagagtgag gttccctata aaagagaaga ggaagcctta gaggagagga 2760
gactctcccg tggtgagatt ccaacgttgc agaggagtta agtgtgaggc actcccggag 2820
caaagtctat gaaggatctt ctgcaagagg ctgcctcctg gtccactgaa cctggaaact 2880
gagtgggctt taaccaggag ataaaaatgg agcctgaagg gaatcaggca aggaaatgaa 2940
ctcaggattc agagatcttt gaattaatat gtggtgggtt ctgacattat tcttccataa 3000
gaccatgtgg gtttccatgg tggctatcaa taaaactcct taggaaaact taaaaaaaaa 3060
3060
<210> 78
<211> 3250
<212> DNA
<213> Homo sapiens
<400> 78
ccggccggga ttcaggaagc gcggatctcc cggccgccgg cgcccagccg tcccggaggc 60
tgagcagtgc agacgggcct ggggcaggca tggcggattc cagcgaaggc ccccgcgcgg 120
ggcccgggga ggtggctgag ctccccgggg atgagagtgg caccccaggt ggggaggctt 180
ttcctctctc ctccctggcc aatctgtttg agggggagga tggctccctt tcgccctcac 240
cggctgatgc cagtcgccct gctggcccag gcgatgggcg accaaatctg cgcatgaagt 300
tccagggcgc cttccgcaag ggggtgccca accccatcga tctgctggag tccaccctat 360
atgagtcctc ggtggtgcct gggcccaaga aagcacccat ggactcactg tttgactacg 420
gcacctatcg tcaccactcc agtgacaaca agaggtggag gaagaagatc atagagaagc 480
agccgcagag ccccaaagcc cctgcccctc agccgccccc catcctcaaa gtcttcaacc 540
ggcctatcct ctttgacatc gtgtcccggg gctccactgc tgacctggac gggctgctcc 600
cattcttgct gacccacaag aaacgcctaa ctgatgagga gtttcgagag ccatctacgg 660
ggaagacctg cctgcccaag gccttgctga acctgagcaa tggccgcaac gacaccatcc 720
ctgtgctgct ggacatcgcg gagcgcaccg gcaacatgag ggagttcatt aactcgccct 780
tccgtgacat ctactatcga ggtcagacag ccctgcacat cgccattgag cgtcgctgca 840
aacactacgt ggaacttctc gtggcccagg gagctgatgt ccacgcccag gcccgtgggc 900
gcttcttcca gcccaaggat gaggggggct acttctactt tggggagctg cccctgtcgc 960
tggctgcctg caccaaccag ccccacattg tcaactacct gacggagaac ccccacaaga 1020
aggcggacat gcggcgccag gactcgcgag gcaacacagt gctgcatgcg ctggtggcca 1080
ttgctgacaa cacccgtgag aacaccaagt ttgttaccaa gatgtacgac ctgctgctgc 1140
tcaagtgtgc ccgcctcttc cccgacagca acctggaggc cgtgctcaac aacgacggcc 1200
tctcgcccct catgatggct gccaagacgg gcaagattgg gatctttcag cacatcatcc 1260
ggcgggaggt gacggatgag gacacacggc acctgtcccg caagttcaag gactgggcct 1320
atgggccagt gtattcctcg ctttatgacc tctcctccct ggacacgtgt ggggaagagg 1380
cctccgtgct ggagatcctg gtgtacaaca gcaagattga gaaccgccac gagatgctgg 1440
ctgtggagcc catcaatgaa ctgctgcggg acaagtggcg caagttcggg gccgtctcct 1500
tctacatcaa cgtggtctcc tacctgtgtg ccatggtcat cttcactctc accgcctact 1560
accagccgct ggagggcaca ccgccgtacc cttaccgcac cacggtggac tacctgcggc 1620
tggctggcga ggtcattacg ctcttcactg gggtcctgtt cttcttcacc aacatcaaag 1680
acttgttcat gaagaaatgc cctggagtga attctctctt cattgatggc tccttccagc 1740
tgctctactt catctactct gtcctggtga tcgtctcagc agccctctac ctggcaggga 1800
tcgaggccta cctggccgtg atggtctttg ccctggtcct gggctggatg aatgcccttt 1860
acttcacccg tgggctgaag ctgacgggga cctatagcat catgatccag aagattctct 1920
tcaaggacct tttccgattc ctgctcgtct acttgctctt catgatcggc tacgcttcag 1980
ccctggtctc cctcctgaac ccgtgtgcca acatgaaggt gtgcaatgag gaccagacca 2040
actgcacagt gcccacttac ccctcgtgcc gtgacagcga gaccttcagc accttcctcc 2100
tggacctgtt taagctgacc atcggcatgg gcgacctgga gatgctgagc agcaccaagt 2160
accccgtggt cttcatcatc ctgctggtga cctacatcat cctcaccttt gtgctgctcc 2220
tcaacatgct cattgccctc atgggcgaga cagtgggcca ggtctccaag gagagcaagc 2280
acatctggaa gctgcagtgg gccaccacca tcctggacat tgagcgctcc ttccccgtat 2340
tcctgaggaa ggccttccgc tctggggaga tggtcaccgt gggcaagagc tcggacggca 2400
ctcctgaccg caggtggtgc ttcagggtgg atgaggtgaa ctggtctcac tggaaccaga 2460
acttgggcat catcaacgag gacccgggca agaatgagac ctaccagtat tatggcttct 2520
cgcataccgt gggccgcctc cgcagggatc gctggtcctc ggtggtaccc cgcgtggtgg 2580
aactgaacaa gaactcgaac ccggacgagg tggtggtgcc tctggacagc atggggaacc 2640
cccgctgcga tggccaccag cagggttacc cccgcaagtg gaggactgat gacgccccgc 2700
tctagggact gcagcccagc cccagcttct ctgcccactc atttctagtc cagccgcatt 2760
tcagcagtgc cttctggggt gtccccccac accctgcttt ggccccagag gcgagggacc 2820
agtggaggtg ccagggaggc cccaggaccc tgtggtcccc tggctctgcc tccccaccct 2880
ggggtggggg ctcccggcca cctgtcttgc tcctatggag tcacataagc caacgccaga 2940
gcccctccac ctcaggcccc agcccctgcc tctccattat ttatttgctc tgctctcagg 3000
aagcgacgtg acccctgccc cagctggaac ctggcagagg ccttaggacc ccgttccaag 3060
tgcactgccc ggccaagccc cagcctcagc ctgcgcctga gctgcatgcg ccaccatttt 3120
tggcagcgtg gcagctttgc aaggggctgg ggccctcggc gtggggccat gccttctgtg 3180
tgttctgtag tgtctgggat ttgccggtgc tcaataaatg tttattcatt gacggtggaa 3240
aaaaaaaaaa 3250
<210> 79
<211> 2730
<212> DNA
<213> Homo sapiens
<400> 79
gtccactggg cttggagtca gtggcaataa ccaggggcaa taaccaggcg tgtcccaggg 60
gggagccccg ctctgcagcc ctgtgcgccg tagagagctg gacttaggct ggcagcatgg 120
ccgagttcag ggtcagggtg tccaccggag aagccttcgg ggctggcaca tgggacaaag 180
tgtctgtcag catcgtgggg acccggggag agagcccccc actgcccctg gacaatctcg 240
gcaaggagtt cactgcgggc gctgaggagg acttccaggt gacgctcccg gaggacgtag 300
gccgagtgct gctgctgcgc gtgcacaagg cgcccccagt gctgcccctg ctggggcccc 360
tggccccgga tgcctggttc tgccgctggt tccagctgac accgccgcgg ggcggccacc 420
tcctcttccc ctgctaccag tggctggagg gggcggggac cctggtgctg caggagggta 480
cagccaaggt gtcctgggca gaccaccacc ctgtgctcca gcaacagcgc caggaggagc 540
ttcaggcccg gcaggagatg taccagtgga aggcttacaa cccaggttgg cctcactgcc 600
tggatgaaaa gacagtggaa gacttggagc tcaatatcaa atactccaca gccaagaatg 660
ccaactttta tctacaggct ggctctgctt ttgcagagat gaaaatcaag gggttgctgg 720
accgcaaggg gctctggagg agtctgaatg agatgaaaag gatcttcaac ttccggagga 780
ccccagcagc tgagcacgca tttgagcact ggcaggagga cgccttcttc gcctcccagt 840
tcctgaatgg tctcaaccct gtcctgatcc gccgctgtca ctacctccca aagaacttcc 900
ccgtcactga tgccatggtg gcctcagtgt tgggtcctgg gaccagcttg caggctgagc 960
tagagaaggg ctccctgttc ttggtggatc acggcatcct ctctggcatc cagaccaatg 1020
tcattaatgg gaagcctcag ttctctgcgg ccccaatgac cctgctatac cagagcccag 1080
gctgcgggcc gctgctgcct ctcgccatcc agctcagcca gacccccggc ccaaacagcc 1140
ccatcttcct gcccactgat gacaagtggg actggttgct ggccaagacc tgggtgcgca 1200
atgccgagtt ctccttccat gaggccctca cgcacctgct gcactcacat ctgctgcctg 1260
aggtcttcac cctggctacc ctgcgtcagc tgccccactg ccaccctctc ttcaagctgc 1320
tgatcccgca cacccgatac accctgcaca tcaacacact cgcccgggag ctgcttatcg 1380
tgccagggca ggtggtggac aggtccacag gcatcggcat tgaaggcttc tctgagttga 1440
tacagaggaa catgaagcag ctgaactatt ctctcctgtg tctgcctgag gatatccgga 1500
cccgaggagt tgaagacatc ccaggctact actaccgtga tgatgggatg cagatctggg 1560
gtgcagtgga acgctttgtc tctgaaatca tcggtatcta ctacccaagt gatgagtctg 1620
tccaagatga cagagagctc caggcctggg tcagagagat cttctccaag ggcttcctaa 1680
accaggagag ctcaggtata ccctcctcac tggagacccg ggaagccctg gtgcagtatg 1740
tcaccatggt gatattcacc tgctccgcca agcatgcggc tgtcagtgca gggcagtttg 1800
actcctgtgc ttggatgccc aacctgccac ccagcatgca gctgccacca cccacctcca 1860
aaggcctggc aacatgcgag ggcttcatag ccaccctccc acctgtcaat gccacatgtg 1920
atgtcatcct tgctctctgg ttgctgagca aggagcctgg agaccaaagg cccctgggca 1980
cctatccgga tgagcacttc acagaggagg cccctcggcg gagcatcgcc accttccaga 2040
gccgcctggc ccagatctcg aggggcatcc aggagcggaa ccagggcctg gtgctgccct 2100
acacctacct agaccctccc ctcatcgaga acagcgtctc catctaaatc ccaggggaac 2160
acaggcccag atgacatccc tttgaccaca tcgctctagg ataactggca cccagagaaa 2220
aggactcctc agaaaaaaca ggcccccatg tgcctctcct gggacaacca gactctgtaa 2280
ctcaccccca ccaccataca cacacacaaa aacagaaaca aaatcaaaac agagaaagca 2340
gaaaatctac caagaacaga gtctcaggac agaaccactg agtcttttgg aggctccaag 2400
cctcaaagtg cccgcagagc ccaccttgag ggttttgcta gttggttttg ttttgcgttt 2460
tacagccgtg gggggaagca cataatcccg ccccagggcc cactagcatc cactgattgg 2520
accttatggt cacccaactc aaggacagcc accaagaagt ggctgccaaa gagactgggc 2580
gcagtggctc atgcccataa tcccagcact ttgggagatg gaggcgggaa aatcatttga 2640
ggtcagaagt tcaaggccag cctggacgac atagcgagac tccacctcta ccaaaaaata 2700
aaaattaaaa aacaaaaaaa aaaaaaaaaa 2730
<210> 80
<211> 1351
<212> DNA
<213> Homo sapiens
<400> 80
gtgatggaga gcaccagcaa agccttaggg cccatccctg gcctcctgtt acccacagag 60
gggtaggccc ttggctctct tccactatga cgtcagcttc cattcttcct ttcttataga 120
caattttcca tttcaaggaa atcagagccc ttaatagttc agtgaggtca ctttgctgag 180
cacaatccca tacccttcag cctctgctcc acagagccta agcaaaagat agaaactcac 240
aacttccttg ttttgttatc tggaaattat cccaggatct ggtgcttact cagcatattc 300
aaggaaggtc ttacttcatt cttccttgat tgtgaccatg cccaggctct ctgctcccta 360
taaaaggcag gcagagccac cgaggagcag agaggttgag aacaacccag aaaccttcac 420
ctctcatgct gaagctcaca cccttgccct ccaagatgaa ggtttctgca gcgcttctgt 480
gcctgctgct catggcagcc actttcagcc ctcagggact tgctcagcca gattcagttt 540
ccattccaat cacctgctgc tttaacgtga tcaataggaa aattcctatc cagaggctgg 600
agagctacac aagaatcacc aacatccaat gtcccaagga agctgtgatc ttcaagacca 660
aacggggcaa ggaggtctgt gctgacccca aggagagatg ggtcagggat tccatgaagc 720
atctggacca aatatttcaa aatctgaagc catgagcctt catacatgga ctgagagtca 780
gagcttgaag aaaagcttat ttattttccc caacctcccc caggtgcagt gtgacattat 840
tttattataa catccacaaa gagattattt ttaaataatt taaagcataa tatttcttaa 900
aaagtattta attatattta agttgttgat gttttaactc tatctgtcat acatcctagt 960
gaatgtaaaa tgcaaaatcc tggtgatgtg ttttttgttt ttgttttcct gtgagctcaa 1020
ctaagttcac ggcaaaatgt cattgttctc cctcctacct gtctgtagtg ttgtggggtc 1080
ctcccatgga tcatcaaggt gaaacacttt ggtattcttt ggcaatcagt gctcctgtaa 1140
gtcaaatgtg tgctttgtac tgctgttgtt gaaattgatg ttactgtata taactatgga 1200
attttgaaaa aaaatttcaa aaagaaaaaa atatatataa tttaaaacta aaaaaaaaaa 1260
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1320
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a 1351
<210> 81
<211> 1780
<212> DNA
<213> Homo sapiens
<400> 81
gcagagctac catgtcctct tggagcagac agcgaccaaa aagcccaggg ggcattcaac 60
cccatgtttc tagaactctg ttcctgctgc tgctgttggc agcctcagcc tggggggtca 120
ccctgagccc caaagactgc caggtgttcc gctcagacca tggcagctcc atctcctgtc 180
aaccacctgc cgaaatcccc ggctacctgc cagccgacac cgtgcacctg gccgtggaat 240
tcttcaacct gacccacctg ccagccaacc tcctccaggg cgcctctaag ctccaagaat 300
tgcacctctc cagcaatggg ctggaaagcc tctcgcccga attcctgcgg ccagtgccgc 360
agctgagggt gctggatcta acccgaaacg ccctgaccgg gctgcccccg ggcctcttcc 420
aggcctcagc caccctggac accctggtat tgaaagaaaa ccagctggag gtcctggagg 480
tctcgtggct acacggcctg aaagctctgg ggcatctgga cctgtctggg aaccgcctcc 540
ggaaactgcc ccccgggctg ctggccaact tcaccctcct gcgcaccctt gaccttgggg 600
agaaccagtt ggagaccttg ccacctgacc tcctgagggg tccgctgcaa ttagaacggc 660
tacatctaga aggcaacaaa ttgcaagtac tgggaaaaga tctcctcttg ccgcagccgg 720
acctgcgcta cctcttcctg aacggcaaca agctggccag ggtggcagcc ggtgccttcc 780
agggcctgcg gcagctggac atgctggacc tctccaataa ctcactggcc agcgtgcccg 840
aggggctctg ggcatcccta gggcagccaa actgggacat gcgggatggc ttcgacatct 900
ccggcaaccc ctggatctgt gaccagaacc tgagcgacct ctatcgttgg cttcaggccc 960
aaaaagacaa gatgttttcc cagaatgaca cgcgctgtgc tgggcctgaa gccgtgaagg 1020
gccagacgct cctggcagtg gccaagtccc agtgagacca ggggcttggg ttgagggtgg 1080
ggggtctggt agaacactgc aacccgctta acaaataatc ctgcctttgg ccgggtgcgg 1140
gggctcacgc ctgtaatccc agcactttgg gaggcccagg tgggcggatc acgaggtcag 1200
gagatcgaga ccatcttggc taacatggtg aaaccctgtc tctactaaaa atataaaaaa 1260
ttagccaggc gtggtggtgg gcacctgtag tcccagcaac tcgggaggct gaggcaggag 1320
aatggcgtga acttgggagg cggagcttgc ggtgagccaa gatcgtgcca ctgcactcta 1380
gcctgggcga cagagcaaga ctgtctcaaa aaaattaaaa ttaaaattaa aaacaaataa 1440
tcctgccttt tacaggtgaa actcggggct gtccatagcg gctgggaccc cgtttcatcc 1500
atccatgctt cctagaacac acgatgggct ttccttaccc atgcccaagg tgtgccctcc 1560
gtctggaatg ccgttccctg tttcccagat ctcttgaact ctgggttctc ccagcccctt 1620
gtccttcctt ccagctgagc cctggccaca ctggggctgc ctttctctga ctctgtcttc 1680
cccaagtcag ggggctctct gagtgcaggg tctgatgctg agtcccactt agcttggggt 1740
cagaaccaag gggtttaata aataaccctt gaaaactgga 1780
<210> 82
<211> 3294
<212> DNA
<213> Homo sapiens
<400> 82
aattcccctc agctgttata aagaggacta gaggctggag agtaaaaaga actgggggta 60
agagcccctc tgcctagcac tgctccccca aggctcccag aaatctcagg tcagaggcac 120
ggacagcctc tggagctctc gtctggtggg accatgaact gccagcagct gtggctgggc 180
ttcctactcc ccatgacagt ctcaggccgg gtcctggggc ttgcagaggt ggcgcccgtg 240
gactacctgt cacaatatgg gtacctacag aagcctctag aaggatctaa taacttcaag 300
ccagaagata tcaccgaggc tctgagagct tttcaggaag catctgaact tccagtctca 360
ggtcagctgg atgatgccac aagggcccgc atgaggcagc ctcgttgtgg cctagaggat 420
cccttcaacc agaagaccct taaatacctg ttgctgggcc gctggagaaa gaagcacctg 480
actttccgca tcttgaacct gccctccacc cttccacccc acacagcccg ggcagccctg 540
cgtcaagcct tccaggactg gagcaatgtg gctcccttga ccttccaaga ggtgcaggct 600
ggtgcggctg acatccgcct ctccttccat ggccgccaaa gctcgtactg ttccaatact 660
tttgatgggc ctgggagagt cctggcccat gccgacatcc cagagctggg cagtgtgcac 720
ttcgacgaag acgagttctg gactgagggg acctaccgtg gggtgaacct gcgcatcatt 780
gcagcccatg aagtgggcca tgctctgggg cttgggcact cccgatattc ccaggccctc 840
atggccccag tctacgaggg ctaccggccc cactttaagc tgcacccaga tgatgtggca 900
gggatccagg ctctctatgg caagaagagt ccagtgataa gggatgagga agaagaagag 960
acagagctgc ccactgtgcc cccagtgccc acagaaccca gtcccatgcc agacccttgc 1020
agtagtgaac tggatgccat gatgctgggg ccccgtggga agacctatgc tttcaagggg 1080
gactatgtgt ggactgtatc agattcagga ccgggcccct tgttccgagt gtctgccctt 1140
tgggaggggc tccccggaaa cctggatgct gctgtctact cgcctcgaac acaatggatt 1200
cacttcttta agggagacaa ggtgtggcgc tacattaatt tcaagatgtc tcctggcttc 1260
cccaagaagc tgaatagggt agaacctaac ctggatgcag ctctctattg gcctctcaac 1320
caaaaggtgt tcctctttaa gggctccggg tactggcagt gggacgagct agcccgaact 1380
gacttcagca gctaccccaa accaatcaag ggtttgttta cgggagtgcc aaaccagccc 1440
tcggctgcta tgagttggca agatggccga gtctacttct tcaagggcaa agtctactgg 1500
cgcctcaacc agcagcttcg agtagagaaa ggctatccca gaaatatttc ccacaactgg 1560
atgcactgtc gtccccggac tatagacact accccatcag gtgggaatac cactccctca 1620
ggtacgggca taaccttgga taccactctc tcagccacag aaaccacgtt tgaatactga 1680
ctgctcaccc acagacacaa tcttggacat taacccctga ggctccacca cccacccttt 1740
catttccccc ccagaagcct aaggcctaat agctgaatga aatacctgtc tgctcagtag 1800
aaccttgcag gtgctgtagc aggcgcaaga ccgtagatct caggcctcta acacttccaa 1860
ctccagccac cactttcctg tgcattttca ctcctgagaa gtgctcccct aactcagatc 1920
ccctaactta gatttggccc ccaactccat ttcctgtctg tcttagacag cccttccaac 1980
tgtgtcatct cttctctgga ggtcaatggt ggagggagat gcctgggtcc tgttcttcct 2040
acataaaatg caagaaaaca gcatggccag taaactgagc aagggccttg gaatccttga 2100
gaatcacatt tatgtgctta tgattacggg caagctaatt aaccttgttg aatctcagat 2160
tccccatttg caacattagg ttaagaccag tactgcagga ttgttgcact aaatgaaata 2220
ctgtatgtga agtgcctggc acagtgtctg gtacatttgt gtttaataaa agctaactcc 2280
atgttcataa gagaggactg aacagctctt cctctagctg tctggctgta taactcttac 2340
agtagtctgt ataataaggg catctctatt agatctttag gggacagagg atttgtcaag 2400
atggttagct ctttgttttg gggtgcagag aaagaaaaga gcagcaacag cagaggctgg 2460
actccctggt tcagtattta atgccatttt attcacatgc tcccatgttc tccctccctc 2520
ccattgtagc cttgctgccc aggggaggga tatgtcttcc tttatgcatc tgggaaacca 2580
ggaacagacc ctgcgcagga gagtcagagg gggaagagtt agaatgggtc agtggctgga 2640
acaaagttct ggttaaggag gaaattagtg ccacccacgg tgagaagcag agaaggcact 2700
tgcatcctat gcagccctga agaccaggct cctttgggca aaaggcaaga ctctggcagg 2760
tgggtcaatg ctctctcctt ggagcaagaa gccagctttt ggggaaggca ggtcctgagg 2820
caggcactgc cctgtggtct tccccaggtt gaggagagaa gtggaagccc catggaagac 2880
agtgctccca gctgaggtag gaggcggagg tgggggtggg ggtagtttaa gcctatgggg 2940
cccaggggga aaggccaaac agaaacccaa ctacccccta atgaagggcc tggaggttgg 3000
ggtatcttgg agctcctcag agcccttctt cccatcaaaa aggtatcaaa tgccttggaa 3060
gctccctgat cctacaaaac aaaaaaatgc ttatttttac cactgtgagg caagctgagg 3120
tgaacattta aaaggctatt tcaagacgag gtgcggtggc tataatccta gcactttggg 3180
aggctgaagc aggaggatca cttgagccca ggagttcaag accagcttgg gcaacatagg 3240
gagaccctgt ctctgcaaaa aaataaaaac gaatacataa aaattaaaaa aaaa 3294
<210> 83
<211> 79
<212> DNA
<213> Homo sapiens
<400> 83
tgtaaatgat gacttcactt ttttccccat cagatcgaca atgctgacgt cttatatttt 60
gccagttagt tctgataca 79
<210> 84
<211> 98
<212> DNA
<213> Homo sapiens
<400> 84
gatgttgatg cacgtgacgg ggagggcata ggagagggtt gatataaaat gcaattacag 60
cctcttatgc tttccaaagt gggggatgat tcaatgat 98
<210> 85
<211> 1812
<212> DNA
<213> Homo sapiens
<400> 85
gcattgctac ctgcccttct caaagcccac atgttgtatt ttatgcaaat ctacagatta 60
tctatcatta tctaaatgca ggcatctgaa aaccagcagt aatcctgcct ctgaagttta 120
tcaggaaagg agcttaaaag agaaccaaat tcagcctgtg ttggaactct cagtcccaga 180
ggggtgtggt ttgtagctct ccggcctgct gttggactta ggctgtgacc cacagaagga 240
cgccagaaag tactcaagac attcacggtg ccccggtcag cactcgccat gacgaagact 300
tctacatgca tataccactt ccttgttctg agctggtata ctttcctcaa ttattacatc 360
tcacaggaag gaaaagacga ggtgaaaccc aaaatcttgg caaatggtgc aaggtggaaa 420
tatatgacgc tgcttaatct gctcttgcag accattttct acggggtcac ctgcctggat 480
gatgtgctga aaagaaccaa agggggaaaa gacattaagt tcctaactgc cttcagagac 540
ctgcttttca ccactctggc ttttcctgta tccacgtttg tatttttggc attctggatc 600
ctctttctct acaatcgaga tctcatttac cccaaggtcc tagatactgt catccccgtg 660
tggctgaatc atgcaatgca cactttcata ttccccatca cattggctga agtcgtcctc 720
aggcctcact cctatccatc aaagaagaca ggactcacct tgctggctgc tgccagcatt 780
gcttacatca gccgcatcct atggctctac tttgagacgg gtacctgggt gtatcctgtg 840
tttgccaaac tcagcctctt gggtctagca gctttcttct ctctcagcta cgtcttcatc 900
gccagcatct acctacttgg agagaagctc aaccactgga aatggggtga catgaggcag 960
ccacggaaga agaggaagta attgcacacc attttccaag aaccaagaaa gaagaaaaca 1020
caagagattt ttctcatctt tttttttttt ttctggtgga gggaggtggt ggaggaacat 1080
agcaaagtag gagggacaga gagtgatact taaatttaat aagaggttcg tgaaggtagc 1140
ttaacttgag aactcttggt tttttgaaag gttgactgca catgccaaaa acaactcctg 1200
ctatctcaga attaattatc tttgaccttc gtggaggatg gtctctggtt aaaatctggc 1260
caaagaaact cacataaact tggtgttaga gaacatctag agagagagag aggaacttag 1320
agtcatttaa actcttcagt ttacagagaa ggatgctgag gacctagatg agaagttacc 1380
tgcaaaaggc aaaagggtta cttagtgtca gaaccaaggc aatgacttct ctctcccaga 1440
tctcctagct actggtcctg ggccattttt ttttttttaa ataatcccaa ctttctttaa 1500
aagacaagca tttcagtaag ctagttattt tcatgggttg ctcatccatt tttttcagtg 1560
atctaaaaat gtagggagat ggctactact gaagttgtct gtctacttgg gataatagca 1620
aattaattga agacaatggg aaagtaagtt ataaaaaata ctgggaaatc tgtttctctt 1680
ctgagcaagc attcagggca ggtataaaca tcaaacatag tgacattgtc aaaacctctt 1740
ccatttgaac attgattaat tcatcaaata aatggtatag taataaattt tgcttgcaga 1800
agaaaaaaaa aa 1812
<210> 86
<211> 655
<212> DNA
<213> Homo sapiens
<400> 86
ctggcatccc gagaagccag gaagcagtga gcccaggagt cctcggccag ccctgcctgc 60
ccaccaggag gatgaaggtc tccgtggctg ccctctcctg cctcatgctt gttactgccc 120
ttggatccca ggcccgggtc acaaaagatg cagagacaga gttcatgatg tcaaagcttc 180
cattggaaaa tccagtactt ctggacatgc tctggaggag aaagattggt cctcagatga 240
ccctttctca tgctgcagga ttccatgcta ctagtgctga ctgctgcatc tcctacaccc 300
cacgaagcat cccgtgttca ctcctggaga gttactttga aacgaacagc gagtgctcca 360
agccgggtgt catcttcctc accaagaagg ggcgacgttt ctgtgccaac cccagtgata 420
agcaagttca ggtttgcatg agaatgctga agctggacac acggatcaag accaggaaga 480
attgaacttg tcaaggtgaa gggacacaag ttgccagcca ccaactttct tgcctcaact 540
accttcctga attatttttt taagaagcat ttattcttgt gttctggatt tagagcaatt 600
catctaataa acagtttctc acttttaaaa aaaaaaaaaa aaaaaaaaaa aaaaa 655
<210> 87
<211> 2282
<212> DNA
<213> Homo sapiens
<400> 87
gttgtacttt tagcttcccc catcctgcaa ggccactcaa ccatgtgcta gctggagtga 60
tctttattca caatgtcttt acaaaggctc ctgcaacaca gcagcaatgg caatttggcg 120
gacttctgcg ctgggccagc gtatagctct tactccacac tcaccggcag ccttacgatg 180
gacgataata gaaggattca aatgctagca gacacggtgg ctactctgcc tcggggacga 240
aagcagcttg ctttgaccag atcaagttct ttaagtgact tttcctggtc tcaaagaaag 300
cttgttactg tggagaagca ggataatgaa acatttggat ttgaaattca gtcttacagg 360
ccccagaatc agaatgcctg ctcctcggaa atgttcactt tgatatgcaa aatacaggag 420
gacagcccag ctcactgtgc tggcctgcaa gctggtgatg tccttgcaaa tatcaatggt 480
gtgagcacag aaggttttac ctacaaacaa gtcgttgacc tgatcagatc gtccggaaac 540
ctgctaacga tagagactct taatggaaca atgattctga aaagaacgga gcttgaagca 600
aagctgcagg ttttaaagca aactttgaaa caaaaatggg tggagtacag atctctgcag 660
ttacaggaac atcgtctgct tcatggtgat gcagctaatt gccccagttt ggaaaacatg 720
gacttggatg aattgtcttt gtttggaccc ctgcctgggc caggcccagc ccttgtggac 780
cggaatcgat tatccagtga gagcagctgt aagagctggc tgagctccat gacgatggac 840
agtgaagatg gctaccagac gtgtgtgtct gaggactcca gcaggggtgc cttcagtcgg 900
cagacgagta cagatgatga gtgctttatc cccaaggagg gggatgattt tctgaggagg 960
tcatcttcaa ggaggaaccg gagcatcagt aacaccagca gcggatccat gtctcccttg 1020
tgggagggca acttatcaag catgtttggg accctgcccc ggaagagcag aaagggaagt 1080
gtccgaaagc aactcttgaa atttatccct ggccttcatc gtgctgtgga agaggaagaa 1140
agtcgctttt gacggattgt ggtgtccttt caaattagct tatttcacaa atatctctag 1200
actcacccag atcccagctt ggtgggaaag tgcagaagaa ttgcaaaact gacatcccat 1260
ttcacagcaa tagtgacctt tatttaaatt gttgtgttat agtttatgct tcttaaatca 1320
tttttcaacc taaacagcca atttctaagc agacaggaaa actaaataat aagttaatta 1380
atataacaaa gatgcaggtt cctgctcatt ccagtaatgt ctttgaaagc aaaactaata 1440
tttattttct agattatccc tgtgaataat tgagaacttt ttggagtcaa gtatgaataa 1500
aggtgtggca gaatataata atctggacta ttttctatag gataattgct gggttataaa 1560
atcttaggtt tgcttatgcc cagtagctcc tgcggaggct taataatagg caattttgaa 1620
tttgttcaaa cctgtaatgg cttgtaaaca aagatgacca tcagctgttt ctcacatcta 1680
tagtgacaat aaagcgggaa gtataagatt taataggagg ggttaaggtt catgagaacc 1740
atggaaagat gtggtctgag atgggtgctg caaagatcat aataaagtca tttttataga 1800
cagtctaaac aaaatgggtg gggatgtcgt gttttttgcc caattcagct tttgttctgc 1860
ctgaacatta atggcaagtc tagaactctc cgaatcctac agctttgtaa ttttttttct 1920
acaaatgtct aacatccaaa actgagggtt gggaaaagga cttccctcct gtagtttttt 1980
tcatattact tctcacttta tatcttatat tctaaatagc tatcacctca gcagtctttt 2040
gcctattggt tatgttagta tcacattact tctagccttt caattactcc atgttttatt 2100
taatatccat tgaagtctat gaattctctg ttctggtggc acagctattc ataacctata 2160
ttctagagta gacaatctgg actatgtaat aaatagtctg ctgattttaa aaaaaaaaaa 2220
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2280
aa 2282
<210> 88
<211> 668
<212> DNA
<213> Homo sapiens
<400> 88
gttggatgaa accttcctcc tactgcacag cccgcccccc tacagccccg gtccccacgc 60
ctagaagaca gcggaactaa gaaaagaaga ggcctgtgga cagaacaatc atgtctgact 120
ccctggtggt gtgcgaggta gacccagagc taacagaaaa gctgaggaaa ttccgcttcc 180
gaaaagagac agacaatgca gccatcataa tgaaggtgga caaagaccgg cagatggtgg 240
tgctggagga agaatttcag aacatttccc cagaggagct caaaatggag ttgccggaga 300
gacagcccag gttcgtggtt tacagctaca agtacgtgca tgacgatggc cgagtgtcct 360
accctttgtg tttcatcttc tccagccctg tgggctgcaa gccggaacaa cagatgatgt 420
atgcagggag taaaaacagg ctggtgcaga cagcagagct cacaaaggtg ttcgaaatcc 480
gcaccactga tgacctcact gaggcctggc tccaagaaaa gttgtctttc tttcgttgat 540
ctctgggctg gggactgaat tcctgatgtc tgagtcctca aggtgactgg ggacttggaa 600
cccctaggac ctgaacaacc aagactttaa ataaatttta aaatgcaaaa actcggagaa 660
aaaaaaaa 668
<210> 89
<211> 14460
<212> DNA
<213> Homo sapiens
<400> 89
gcggggcggc gggcgtgtcc gaagtcgcgc gcggctggcg cgcggtcccg agtgaaagga 60
gaaggagggg cgctgggggt gacggtgcgg agccgctgcc agcgctgggc gagagtcggc 120
ggccggatcc gaggagcagg cgggcctgag gccgagtcag ctgcgcgggc ccccggatcc 180
cccgacagag cggcggcggt gtctggccag gcggtaggcg ctgcctggcc gcggcgggga 240
agatgttcag cgtagagtcg ctggagcggg cggagctgtg cgagagcctc ctcacttgga 300
tccagacatt taatgtggat gcaccatgcc agaccgtgga agatttaacg aatggggttg 360
tgatggccca ggttcttcaa aagatagatc ctgcatattt tgatgaaaat tggctaaaca 420
gaatcaaaac tgaagtagga gataattgga ggctaaagat aagcaattta aagaaaattt 480
taaaaggaat cttggattat aatcatgaga ttttaggaca gcaaattaat gactttaccc 540
ttcctgatgt gaaccttatt ggggagcatt ctgatgcagc agagcttgga aggatgcttc 600
agctcatctt aggctgtgct gtgaactgtg aacagaagca agagtacatc caagccatta 660
tgatgatgga ggaatctgtt caacatgttg tcatgacagc cattcaagag ctgatgagta 720
aagaatctcc tgtctctgct ggaaatgatg cctatgttga ccttgatcgt cagctgaaga 780
aaactacaga ggaactaaat gaagctttgt cagcaaagga agaaattgct caaagatgcc 840
atgaactgga tatgcaggtt gcagcattgc aggaagagaa aagtagtttg ttggcagaga 900
atcaggtatt aatggaaaga ctcaatcaat ctgattctat agaagaccct aacagtccag 960
caggaagaag gcatttgcag ctccagactc aattagaaca gctccaagaa gaaacattca 1020
gactagaagc agccaaagat gattatcgaa tacgttgtga agagttagaa aaggagatct 1080
ctgaacttcg gcaacagaat gatgaactga ccactttggc agatgaagct cagtctctga 1140
aagatgagat cgacgtgctg agacattctt ctgataaagt atctaaacta gaaggtcaag 1200
tagaatctta taaaaagaag ctagaagacc ttggtgattt aaggcggcag gttaaactct 1260
tagaagagaa gaataccatg tatatgcaga atactgtcag tctagaggaa gagttaagaa 1320
aggccaacgc agcgcgaagt caacttgaaa cctacaagag acaggtagta gaactacaaa 1380
acagattatc cgaagaatca aagaaagcag ataaactaga ttttgaatat aagcggctaa 1440
aagaaaaagt tgacagtctt caaaaagaaa aggacaggct gagaacagaa agggattctc 1500
tgaaggaaac cattgaagag cttcgttgtg tacaagctca agaagggcag ctcacaacac 1560
aagggttaat gcctcttgga agtcaggagt cttcagacag tctagctgca gagattgtta 1620
cacctgaaat cagggagaaa cttattcgtc ttcagcatga gaataagatg ttaaagctta 1680
accaagaagg ttcggacaat gaaaaaatag ccttattgca gagccttcta gatgatgcaa 1740
atctacgcaa gaatgaactg gagacagaga ataggctggt gaatcaaaga cttctggaag 1800
tacagtcaca agttgaagaa ttacaaaaat ctttacagga tcaaggctca aaagcagaag 1860
attcagtcct tctaaaaaag aagcttgaag aacatctaga gaagctgcat gaggccaata 1920
atgaactaca gaagaagaga gccattattg aagatctcga gccaagattt aacaacagct 1980
ccttaaaaat tgaagaatta caagaagctt tacgaaagaa agaggaagaa atgaagcaaa 2040
tggaagaacg atacaaaaaa tacttagaga aagccaaaag tgtcatccgt actttagatc 2100
ctaaacagaa tcaaggagca gcaccagaaa tacaagctct taaaaatcag ctccaggaac 2160
gagaccgact gttccactca ttagagaaag aatatgagaa aacaaagagt cagagagaga 2220
tggaagagaa atatattgtt agtgcctggt acaatatggg aatgaccctg cataaaaagg 2280
cagctgaaga tagactggca agcacaggct cagggcagtc atttctggcg aggcagaggc 2340
aagcgaccag cagcagaaga tcatacccag gccacgtgca gccggccaca gcaaggtaga 2400
gaagttgtgc cgctcaatca cagacacctg cacccacaac atacttctgt tacacacaag 2460
aacatttcag gaaactcagc cagcttattt tttgtttctc ttctatgtca atacttagtg 2520
tttctcattt tgaggacttt ttctctctcc tgtatctttg ttttagtttc tttggttttt 2580
attttgtagt cctttcagtt atttttaatg tgccaaaaat ttgtacatgt tcaattaaaa 2640
atgttgtata atagtgtaat acttttcttt gtatgaaaat gtcctcttct tcaaaggtat 2700
aggctttgta atgaattaga ttttctgcca ataattgata tacaatttat attctttatt 2760
gtgcctgtgt gttaccatgc taagaatgtc tttgtttaaa gggaattaat ctttttatga 2820
tgtattaatc tgtgttttca attgttttcc aagtacagtt caaataactt gcatatttac 2880
tatacaaaat ggttgacaag tgttcttttt gcaaagactt gaatacattg gcagaggtgc 2940
taatcacatc ttccctaagg cacctggaag aattatttga ggaaaaaatg agttttcaca 3000
ttgttttata ggaaattaaa tttgtccaaa gatttggaga ctatttttaa aacataaata 3060
cataaaattt cattatttcc tgctatcttg tttgctggca gaagtgaatg tttggtgagg 3120
ttattttggg ataaattaca aaagaaaaaa aattagacac tgcattaatt tcttgttctt 3180
ttggaatatc ttagtaactg aggatcattt tctaacaatg tggttgacat accttcagtt 3240
gctttccaca tctaaaagag ttatctttca tatatgtaca agttattggt agtcttattt 3300
ttgggctgtt tgttgactta tgccccattt gttttacttg ttctttaata taaacccttc 3360
cattttttaa caattcctaa cacttgatat cttaatatca gtcactaaca ttagtaactt 3420
cttgtatgtt atattatggc agatctcttt acgttttttc tcacatctat ctgctagtcc 3480
aggaatttgt tactaaatag attttcttgg atatttggtt gcctcaaagt gcttacattt 3540
gttaacagat tgtaaaccac atttatttac attgatgaat gggctgttga ataatcattg 3600
taaagcactt tgtatatata aggtgctata taagtgtgaa atatcattca tttataaatg 3660
aaatgccttc taactttcca tattgactta tgtatttggt cccaaattat atttaagtct 3720
tttttcttgc aacgtagccc attttttgaa agcaaaacat ttctgaaatt aggtcatggt 3780
ttttttgttt atttttaggt taggtcactt aatataggag gatgttttct catgtacttg 3840
ctatttgcaa gttcaggttt catttggttc tttatgttaa atacgaataa gtaacctcaa 3900
atcaagctaa atgtaattaa gaattttcag caactatatt caagtgtttg atttttaaat 3960
tctttctttc tttttaataa gaaagatgac ctaaaaatca gtggtatttg tttgtcctca 4020
gaagccgtag ttgaagaaag atattagagt atacacagaa ctggagccat acattgtgct 4080
aattttttac attaagtaca gaagtctgag cacagcatga atgcttctgc ctgacaggac 4140
cacaaagcag cagaagttag ggataaatgg agatagccat gagtagaact gctgtagggc 4200
ttcaggaggc tacgcagacc tgatcaactg caaagtttcc aaagtaaaag attaaaaact 4260
ttcagacggt tcttacctct acccgtgttt cacaaatagc ctgaggatcc aactattttt 4320
aaagcaaatt ggggccagac gtggtgcctc acgcctgcaa tctcaccatt tgggagacct 4380
aggtgggggt ggatcacttg aggtcaggag tttgagacca gcctggccaa catggtgaaa 4440
ccccatctct actaaattac aaaaattagc tgggcatggt ggcatgtggc tgtaatccca 4500
gctacttggg aggctgaggc aggagagtca cttgaactca ggagccagag actgcagtga 4560
gctgagatcg caccactgca ttccagcctg ggcgacagag tgagactctg tctcaatcag 4620
tcaatcaatc aatcaatcaa attggaatat gagcactaac cttggtaagt taaaattttg 4680
ggaaaattgt acctgcagaa tatgatggat gaaaacaaca gccaggtgca gtggctcacg 4740
cgtataatcc cagcactttg ggaggccgag acaggcacat catctgaggt caggacttcc 4800
agaccagcct gtccaacatg gtgaaactcc gtctctacta aaaatacaaa caattagcca 4860
ggcatggtgg tgtgtgcctg tagtcccagc tacttgggag ggtgaggcag gagaattgct 4920
tgaacctggg agacagagat tgcagtgagc cgagatggcg ccattgcacc ccagcctggc 4980
gacaagagcg aaactctgtc gcaagaaaaa aaaaaaaaaa aaaaaaaaaa aaaacagtct 5040
gtgaactact cactgaatga attttgttct gtgagatgag aggttttcat tttcattttc 5100
tatttacagc cccagtccta atctcctacc catccaccta cccagatatt ttttctctat 5160
ctgggttgga aaggccccag gcttttagag gggagtttta cttctgactt ttttttcccc 5220
ccgagacgga gcctcgttcc gtcacccagg ctgtagtgcc gtggcatgat ctcggctcac 5280
tgcagcctct gcctcccggg ttcaagcaat tctcctgcct cagcctccag agtagctggg 5340
attacaggtg cccaccacca tggctggcta atttttgtaa tttagtagag atggtgtttc 5400
accatgttgg ccaggctggt ctcaaactcc tgacctcgtg atctacccac ctcggcctcc 5460
caaagtgctg agattacagg cacgagccac cgcgcccagt cgtacttctg acttttcttc 5520
agcatctgtt gtatgctatt attttgatgt ttacatttat aattttcttt cttttttttt 5580
tttttgtgag atgatgtctc gctctgtcac ccaggctgga gtgcagtggc gcgatctcgg 5640
ctcactgcaa gctccgcctc ccgggttcac gccattctcc tgcctcagcc tcctgagtag 5700
cggggactac aggcgcccgc cactacgccc gactaatttt ttgtattttt tagtagagac 5760
ggggtttcac catgttagcc aggatggtct cgatctcctg acctcgtgat ccacccgcct 5820
cagcctccca gagtgctggg attacaggcg tgagccaccg cgcccagcct acatttataa 5880
ttttcattct cttttaccta taaaattcag tgtattagtt tcattacata ggagaaatta 5940
tatttctaaa cattttatga tgtttaaaaa caaaacaggc tgttgtaaaa aaaaaaaaaa 6000
aaaaaacttc tgaatatact ttaggtatca gaaagccaag aataaaattt agctctaacg 6060
gtggcaactc catgtccggt gtccagcttt ggacagggtt tatgacgttt ctgtttctct 6120
agtaatgatt aatgattcct caggagattc gtgatgttgt ctggtctatc tggaaattta 6180
aagtcactag gagctttgcc tcatcgtgag tgatgctgtg ctgtattttt acaaactctc 6240
gcatacagca ccttcctggg gccacgttgg cttgtgcagt ggagcttgtc caggcaccag 6300
catggagcaa gtacagggtt gctgtgttgg gttggagcac actgtcacca cagtgtctga 6360
agtcttataa acaggaagat cattttctgt tttccttcta accagggtga gaaaatacaa 6420
agtaaagaac taaagaatat taaaacctag catttatgtt ccacagtgtg tatttcagaa 6480
gtttgtaatc cagaaaatat agtagtgtat aatatctgaa aagagaatca agtatacaat 6540
tgtacatatt tttaaagaac tttgaaaaac tccgtcatat cttttaccat ttgtctattt 6600
gatagtaatg cagaaaaaag tccctaaaga ccctgtgttc caaaatttac caagattgac 6660
atttctatta gacatcctta acctaagtgt tttaattaga ttattagact ataataagga 6720
tgaaattgct gtctgtaatt ttgttgaggt tttattgtta atataataaa agctcaactg 6780
tacaaaatta agctaaatgt tatccagtca gaaacatcag cctgtggcca ggtgcggtgg 6840
ctcacgcctg taatcccagc actttgggag gccaaggcag gcggatcacc tgaggtcagg 6900
agttcaagac cagcctggct aatatggtga aaccccatct ctactaaaaa tacagtatta 6960
gccaggcatg gtggcaggcg cctgtgatcc cagctacttg ggaggctgag gcaggagaat 7020
catgtgaacc caggaggtgg aggttgcagt aagccgagat tgtgccactg cactccagcc 7080
tgggccacag agtgagactc catctcaaaa aaaaaaaaaa aaaaaaaaag aaacatcagc 7140
ctgtatattc cagtagttct cacagaagaa tgaaaatccg tgctgtgcaa atagatcagt 7200
agtgagtgag tgttaagtga aagatgagct aggttgaaga aaatatacat tttattgatg 7260
agccactttg ctatctctcc ttccttcctc cttccttcct tccttccttc cttccttcct 7320
tcccttcttt tcttttttct tttcttttct tttctccctc ctttcttcct tcccttccct 7380
tcccctcccc tcccccaggc tggagtgcag aggcacgatc ctggctgact gcaaactctg 7440
cctaccaggt tcaagcgatt ctcctgcctc atcctcccta gtagctagga ttacaggcat 7500
ctgccaccac gcccagctaa tttttgtatt tttacaaaat acaaagagac ggggtttcac 7560
catgttggcc aggctggtct ctaactcctg acctcaggtg atccgtccac cttggcctcc 7620
caaagtgctg ggattacagg cgtgtgttac tgccccagcc tcctatttcc ttttcgaaag 7680
tagcagtttg gtttattctc gtttgctaag taattgtttg aaatattttt cagcctctcc 7740
tgctccctca caaaaattca cctgtcattt taatgataac agcatgttaa aaacttggaa 7800
gtctttatcc caatataaga attatcttga aacaaaaatc taaattactt ttaaaaattc 7860
tcttaactct gcatttagtc tcctattatc tagatctctg agtccaggat aactccagtt 7920
atccccagtt ggatcatgtg tgatttatct gagaaagcat ccacaaccca cagctagtgg 7980
aaaccgagct agtttacagc cacgtggata agaacatctt tgtttctaaa gtgagaggaa 8040
agtgcttggt atcttgcttt ttgctgaggg caaaataaca acatgaagac aaagtgcttt 8100
ttgttgtcta ttcatgaaac tgtagaagaa tattttgagt ttttattctt atattatgaa 8160
gggattcttt gcctagcagt ggccgtcaaa ctgatgtagc attgtacttc tcaacagtga 8220
agcctgtgta ataccataca gtaggatgaa agactattct gagcaaaatc aaatgggatg 8280
tcagaatctt tgaaaattat tttatcattt tttctatttt ttcattttta taaattagaa 8340
ggattttcca ttcaataagg ataatctctc ttcctatcat tctgtcaaaa tggcagtttc 8400
ttttggtaat tatccaacct agtttcatta catttagaag gaggtttcag agcttattct 8460
tgataactat aataatgatt tgaatgtttt atatcatgaa gttttttcta tgaggaaggc 8520
tattctcaat gtatctgtcg tctaattttt tattttctat ctataaagaa tatttaaata 8580
ataattggtg tatgttcctt ttgttgaaaa tgttttattg tccagtttta acacagaagt 8640
ggtctaaagt tttgcagcaa atgctgttca gttcccagaa gcctaaaaaa cataacataa 8700
tatgctaaca gagctaattt ccacccaatc cctcaaatta ccgaagtatt aatatttagc 8760
ttcctttcta gaaaacaagg ggcagcacaa atggggtggc atccatctct tttaaatcac 8820
tgatgatttt ctggggaagt atatatagat gattttattt tttaaatagc cttttatcaa 8880
accatttcac atgtattatc tatatgacta tagaaactta taaaacattt aattcatgtt 8940
gacttaaaac atgggcatcc ttggattctc cacattgact gaaatgatag agaaagggac 9000
atttgtttga gaaacaagag acctgtacct aattatggca agtatatgag ttttggtgat 9060
tgtggggggt tataaatgtt ttcctatgat agataaatat atagatatag atcaggaatt 9120
acttgatgtc tcttcagaag ttttctgttt tcttataatt tccagtaata ctctgtaaga 9180
ctcggtttgc atgctgtgtg tgtttgcatg agtatagaaa cctaagaaca taatggaagg 9240
ctattaaggc aaattcattc ctagaaagtg gagtggatca ttgggataag aaatagccta 9300
attataaaca aatatgcagg cagagggaag tcctaataca atgaaaactt gcattatcta 9360
aacagatgtt cccaaagcaa tagtttgcct aaaatcctct gtattacatg attattcagt 9420
aaaagagtaa acaaatatct aatttatttt ctaattgtcc ttcccttcat tgagtattaa 9480
ctaggtgcat aatgtagttg tatatgttta ctagtaaagg gaaaaacact tattttcatt 9540
ttgagactgt ttggctatta ctaaagctga gaaagtgatt ttaggtcgcc aaggatacta 9600
tgatttgatg agatgagaag aaatctgcgg tggctgaaaa tcgtgaccaa cttggtgtta 9660
tctagatctg ctttatctag tttgcaagcc ataggctcaa ttttatgtcc ttcttactta 9720
cacacagtag ccccacacag ttttgtttta aatgaaggca aaagtagaca tttttaaagt 9780
atattcaaca ttgtgccatt atttacctga taaaggtgaa atcagaggtg tccacggcct 9840
caaagtttgg gcccatggga ctatcaaatc cgaattatat ctacttagag cttagaggaa 9900
gaattaggta tcatgagaaa agcaactcct acttgagaga aagaagacta ccaaagcatg 9960
ttgaggcttt aacatgggag acttccaggt aggcgttaac acttgagtgg taactagctt 10020
gatgaaggaa aataattact ttagcagtta tgttgtaaaa ttaataaaaa ggactcatgt 10080
ttattctggt gtatttgtca acccatgggt agtgattact ccgtgtacat tctatagtgt 10140
gtgtatttta tttagtgtct taatatatag tctttatata gtatcttaat attatttact 10200
gttacttcta gtcatttatg tagtatattt tactgcaaaa tttgtagcac tttactaata 10260
ttagatcatt attttccctc ttcccctcta cctttctggc attttctgtt atcttagagt 10320
caggaatcta aaggtctaag tctagaaatc tgttggaagc tgggttggag ctactggata 10380
tgagttactt tttacatgtc tccttaagaa gactctttta taatgtaata cttagaagcc 10440
aaatcctttc aaacgcaaac acccttgaaa cttgatgctt tctgaagttg tattcataaa 10500
aattatccca tcttacagtt aatcagaaga tgttcttacc tttggtttgc ctgcctcctg 10560
aaacacaaac ctgcagattg cccctaactt cagcagtgcc tccgtcactg catgtaccta 10620
aaagacagga aagccaagtt ctgggagctg tcaagtcgga ggatcaggaa aatggtgggg 10680
aagaggtgac tggaaaggca ggcactaaag atggcaggct gcaaaagcat tctgagttcc 10740
cctgtaacag ataggtttta tgaactcagc tgttttcttt tttctttttt tttcttttga 10800
gatggagtct cactctgagt ctcactctgt tgcccaggct ggagtgcagt ggcacaatct 10860
cagctcactg cagcctccac ctcccggttt caagtgattc tcccacctca gcctcccgag 10920
tagttaggat tacaggtgcc caccaccacg cccaactaat ttttgtattt ttagtaaaga 10980
cagggtgtcg ccatattggc taggctggtt ttgaactcct gacctcaggt aatccacccg 11040
cctcagcctc ccaaagtgct gggattatta taggcgtgag ccaccatgcc cagtgaactt 11100
ggccattttc ttacattcat atatagcaaa gttttcaact tgtctaccga gagactttct 11160
ttaggagcca ggacttctac atttgtaact tgagtatatt aatattcaaa tcatagttca 11220
aaaatactga aatacttgtt tattatgtta cataaatatg gacacaatta ctgccaaaga 11280
atagagagat ttgcttatga gaacattctg tcatttgttc tgtttgtaga tgagagacat 11340
gcttttaaag tacaaaacgt ttctcttcta ccttaccccc tgttctactg acgtgctttg 11400
catgagaagc tcatctagaa gagagcaacg ctggaataga gaagtctaga ccctggcctt 11460
tgagggaaag gactgctttt tttctctccc aaattagaaa attaaaagtg aaacataaca 11520
cataaggacg aaatacaatg ttctgaatat cttccactaa ttaattgttg aatgattaag 11580
tctctaagta tcttaacttc cattgtcttc ttgttaacct agacaagagt agattattca 11640
gtagccacat gtgacagtta aaattaagta aaattaaaac tatagtttct cagtggccta 11700
gccacatttc aagtgttcca cagtcacatg tggatagtag ttacctatca gacagtacag 11760
gtatagaaca tttccagtat tgccaaaaat gctattcaac agcactttta ttgcccagag 11820
agaaaataag gacaaaataa aggcagtgaa gtaacttaag acaactctga gattttacca 11880
ccatacttag agaaagtttt tctgttataa aaattaatac taatcctttt taaagacctt 11940
ggaaaaaatc aaaaccccat tcctttaagc tagtcttcag tatatatttt tctaagaaca 12000
gattctcaat actttatttt tcaagtgata aaatcatttt ataaatcatt tcttaatatc 12060
ttcagtgttt tttccctttt tatgtaaact cttttaaaat tgatattagc tgggcatggt 12120
agctcatgcc tgtagtccca gctactccag aggtcgaggc aggagcatcg cttaagccca 12180
ggaggttcag gctgcagtaa ggtctgatca cacctgactg cactccagcc tgggtggcaa 12240
agcaagaccc ctgtctctaa aaaaaaataa tataaattga tgttatatag ttaacattta 12300
tcaggcaaat tcatatgaat gcttatttca aataaagatt gatagattta atgatatcct 12360
tccttttaaa tttatataga tctaatgaac attgccaaca gttttttttg tttctgtccc 12420
ttaaacattt cccctgaaag tccacctcaa aggtacatca agatgcaaac aattttttta 12480
tcttcataac ttcctgctct tattaacttg tattatgaat caaattaagt tttatgtata 12540
aggcatttac tattccagtg acttagctaa tgaaaacatt taaaaatatg tattaattta 12600
cttggcctgc tactaaagtg cttaacataa ctaaatggat ctatagtaac atgtctaaat 12660
tttttaatgg aaataaggga ctaaccataa tccttttgag tcagcttggt gcttacaatt 12720
attttgttag gaaatcttga tgctttcttc tttctcttta aatttttgta atcaagcaac 12780
agacttgatc cagcagtgtc gaattccaag caagttatga tgattcttat tgtagttcaa 12840
gtacagatga gtaagtggtg tgacttcagt ttattatctt cttggtgacc tactttagta 12900
tgtgttctgt agcgattcat attagttaag ggacgttttc aatatgcttg aaataagaaa 12960
tagcatttta ctctaaatac aagaaatgac tgtacacaaa tgctaatcag tgatttgggg 13020
ccttttaatg tctttaacag caatctttta tttatttatt tatttatttt tgagacggag 13080
tcttgctgtg tcaccaggct ggagcagtgg cacgatctcg cctcactgca acctccgcct 13140
cccaggttca agctattctc ctgcctcagc ctcccaagta actgggactg caggcacatg 13200
ccaccacatc cagctaattt ttgtattttt agtagagacg gggtttcacc ttgttggcca 13260
ggatgatctc gatctcttga tctcgtgatc tgcccgcatt ggcctcctga agtgctggga 13320
ttacaggcat gagccactgc gcccggccca aatcttttat tttttaacag ccttagttat 13380
ttataattca aatgcactaa aatatcatcg ctgtcatgaa ctttgctgtt tacaggttct 13440
gtgtaattca gaatgctttg tacttagaaa ataatttcta ggcttatctt gttttgcagt 13500
tttcatgttt tgacaattgc ccaccattta caatactcaa tttttgatta tgaaatgaat 13560
agtaaaattc aaacatatct aataataatt tgccttagtt tgattaataa attatatcaa 13620
aaaacttggg gatagaaaga ggcttttttt tccccctgta gtatttttaa aactttttag 13680
atgagctgga tgaaacctta gtacattgga gctggagttg tattgagtac agccccaact 13740
ctgaagcctt atattcatgt cttaagtacc attgattgtt ctgtgaattg ttgttagttt 13800
catatttgac attgtagtaa tccaccttgc attttagtct ttgcaaaaag gatattgcta 13860
ggtatattct tatttctgat tgagtattga atttacattt ttcagaattt cattctttgt 13920
cattataatc caaaaacaat gtccacatca gacttggaac ttctcacttc aaaaatgaaa 13980
tacagattta gcagtgttgt acataatgat gtccaagcat ttttccacct gtttactgag 14040
ttttccaacc atttactatg tgttgagatt ggtgggtttt ctggctgttt ttctgaggtg 14100
aatgacttgt tacagagcct cagtaagaaa tttcaactaa aatcacaaaa acataaagtc 14160
caggaaacca ccagaagatg gatttttagt gtttttgaaa tcttgtattt ccttttgata 14220
tcatttactc attttaattt tacgactgcc aacttgttac ggtattaatt atatgtatgt 14280
gtttatatgt atgcatataa tatatgtata tgtatatgaa gaataaagtt aagatttggt 14340
caaactatat tttcccattc aagtacaaaa atgttttcaa ggctgcaaaa agtgtacagt 14400
tgttaaacaa gttgtaaata aagacttgta taaaaattca aaaaaaaaaa aaaaaaaaaa 14460
14460
<210> 90
<211> 2942
<212> DNA
<213> Homo sapiens
<400> 90
attaactggc attctttaaa aaggcatcag ttttcttttg cacaggtgtt tggagagccc 60
ggactggatg cccactagaa tcctgtgctg tgaacagtga gagagttttc ttcattttga 120
ggaaccctaa acacctatct ttcccaaggc aacctgtctg gactgagcat ttctctgact 180
tgacataact tcccatccag ccaggagtct gcactcttca gtctttgcag gcagtagcag 240
aatcccatgg tagccaggtg ggtgaagggg agcgaggacg ttctacctgc cttgaagaag 300
acacctgacc tgcggagtga gtgaccagtg tttccagagc ctggcaatgg atgccattca 360
catcggcatg tccagcaccc ccctggtgaa gcacactgct ggggctgggc tcaaggccaa 420
cagaccccgc gtcatgtcca agagtgggca cagcaacgtg agaattgaca aagtggatgg 480
catataccta ctctacctgc aagacctgtg gaccacagtt atcgacatga agtggagata 540
caaactcacc ctgttcgctg ccacttttgt gatgacctgg ttcctttttg gagtcatcta 600
ctatgccatc gcgtttattc atggggactt agaacccggt gagcccattt caaatcatac 660
cccctgcatc atgaaagtgg actctctcac tggggcgttt ctcttttccc tggaatccca 720
gacaaccatt ggctatggag tccgttccat cacagaggaa tgtcctcatg ccatcttcct 780
gttggttgct cagttggtca tcacgacctt gattgagatc ttcatcaccg gaaccttcct 840
ggccaaaatc gccagaccca aaaagcgggc tgagaccatc aagttcagcc actgtgcagt 900
catcaccaag cagaatggga agctgtgctt ggtgattcag gtagccaata tgaggaagag 960
cctcttgatt cagtgccagc tctctggcaa gctcctgcag acccacgtca ccaaggaggg 1020
ggagcggatt ctcctcaacc aagccactgt caaattccac gtggactcct cctctgagag 1080
ccccttcctc attctgccca tgacattcta ccatgtgctg gatgagacga gccccctgag 1140
agacctcaca ccccaaaacc taaaggagaa ggagtttgag cttgtggtcc tcctcaatgc 1200
cactgtggaa tccaccagcg ctgtctgcca gagccgaaca tcttatatcc cagaggaaat 1260
ctactggggt tttgagtttg tgcctgtggt atctctctcc aaaaatggaa aatatgtggc 1320
tgatttcagt cagtttgaac agattcggaa aagcccagat tgcacatttt actgtgcaga 1380
ttctgagaaa cagcaactcg aggagaagta caggcaggag gatcagaggg aaagagaact 1440
gaggacactt ttattacaac agagcaatgt ctgatcacag gggcgccatc caggtttaac 1500
cctgcaagct gtttccacat cagaactccc ttcaaacaca aagattgctg tgaaaacgaa 1560
aatgtgtaga cgcactctca aaaactgcac ggacatacaa aatcaatctt ttcctttgat 1620
cttgtggcta aaccagcatt tctgtgtttg agagatttcc tgttaggtgc ttcgtctgaa 1680
agtgaactct cataattcaa attgtataaa ataaagctac atttctaaga gcttggtgta 1740
gggcaattgg aataatgtcc tgttagataa acagacattt agcaatcctg acattaaaag 1800
gaaatgtatt tctatacaag attattagct gtaatacaag atatttattt aaccaatgac 1860
cttatggctg agagttgaat tgtggttcag tattcattga tctcactgct ttaaaacatg 1920
ctctttttgt tcaagcagga aaaatattat atctaattat gtctatgtgg taatacctaa 1980
aaagaggtag agagactcta tgttcacaaa atatagtaat ttcattttta cctttcttca 2040
gtggactgaa ttgtatggaa ggaaattgat cagatctgta attcacaact gtggaaacct 2100
acacaaatgg ggctgatgcc attgtttcct ctattttatt ttatttattt ttgaatccac 2160
tatctctttc cattcaaaat atttccattc aaaatgtggt tcacagaccc gccacatcag 2220
caccatccga gagcttatta gtaatgtgta gattctcatg tcccagccag acttacagaa 2280
ttggggtctg tatcttaaca agaaccccag atgatttgtg tacaaatgaa agttcgaaag 2340
ctgtgctctg gacagtgttc tcaaagcaac tttctgaagc cgtgtggaaa actgactctg 2400
tgtgggtccc gtatccctgt ggcatccaga cctggcctct cttcatttca ttattattgg 2460
ccaatatttc tttcagccat ttcatttctt atctattaaa atggcttgcc cataaaggaa 2520
ctgcatagga ttatcccctg acattccaag agcaaaataa agctcttgag agtaattgtt 2580
gtctcagtca tgcttgctga ttacagttag cacaaaagaa aaattcagct gcctgacaat 2640
acaggaaatg ttctcagatg ctgatgtttg taaggtccgg tggggccatg aggaagaaga 2700
ggagctgaag gtaagaaact cataaacaag atgactcttt gatgcatgaa caagatttga 2760
aaatctcaag cctgtaaaga atacccctgc tatttaaata aagctcatac caagaggtaa 2820
cattttgccc cgggccaaat tcaggggtct agtgccctgc attcctttga ggcaaaaaat 2880
aaatgggcta tgactggtta aatgtccaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2940
aa 2942
<210> 91
<211> 4319
<212> DNA
<213> Homo sapiens
<400> 91
gaggccagga ccacgcctga ctcaggcgat cggacgggca gggaggctgc aaggcatggc 60
atgagcaggt ggagctgtca ggactgcccc agcccctggc tcaaagatgc ccgaccccag 120
gaccctgcct cgctggatgg tgaaggccaa cttcccctct gttggagctg gcctgggcgt 180
tgtgggaagg gctgggagga ggcccaggac aatgcagaac agacaggacg tttcacagag 240
caggctgcca tgtccctcgg ggccttgggg gctgctgagg ccctgagaaa ggtcactgga 300
ggcctggccg gaagtgcagg gttatctcag tacttgattt aaggctcctg cagctgaaaa 360
gctgccccac acggcggacc gggtggagga agtcagctgt gctgcttaac cgtggagtct 420
ccgtcccggt cctgctcacc agctctgcaa aggccttgtc ctccctgcct gattctcggc 480
accattttta acacgcctat ggagaggcca cgttgagtcc agaggtccgt gcgcctcatg 540
gccacatcac ggcacccgtt cacccacaca agggccagga gcatccccta gggaggagga 600
gatggcagat ctgcacaggc tctgcgctcc tctctctccg gagcgtcctc tcctctgtgt 660
ggcaggctcg gcgcgtgatg gaggagcccc ttctgcaggg ctctgtttag agggtgcccg 720
ccccacagcc tgtggctgct cctactcatg ccagaacaga aatgggtgcc cagctggtca 780
acatacattt gttaccttgc tttaaaatgc cttgagagtg gaaccaccgg tgcaggcttg 840
gctggtcaag aatcatgttc tagaaattat ttccagtgct gagcacagtc cctgagattt 900
aaaaacgctt atgggatgaa tggaaaatag cagggcctct taccggcctg caacgccttt 960
agaggcacgg atgccacgtg cacagaccca gctccgggaa gcacaagcct ggtggtgtgc 1020
gggaagcggc gaggtgcgcg ggaagcggcg aggtgtgcgg gaagcggcga ggaccggctt 1080
taaagtcaca gcagtttcct gaaagatgag ggggaggagg acagtgacgc tcacagcaca 1140
gccacttgtc aacttggaca tgacacacac aaagcccaga gctcggacgg caccgcgagg 1200
aggctgggat tcacgtcagg cggcacttgg tgggcagtta caagaaagga cggcagccaa 1260
gccagtgcct cctgtgctcc ggctctgggg ccctggacac acctggggat tcagttttgc 1320
atggaccagc attctccaag cgctctgatc agtcttacag gagaagtagg ctgtgtggtc 1380
tgggagcctt gagaaggttc cgctgtaatc tgtcagactt ttggacagga tttttctgcc 1440
ttacgtggct gatgtacgtc tgcaggaggg tagcacacgg caccctctcg gcctgctgtg 1500
ccacaaaacc tttgctttta caggtctcac ggagccagtg ggctgcccaa tgccccagtg 1560
cagagtggag acgaggtctt cccctccttc ccagcttgcc tgggcggcga cgcgtctcag 1620
agacctctgc cagggtcaat cctggcccat gctactagct cggggtgtga agtcacagtt 1680
gatgctgaac acctggctgg gccagacttg tgcccaagaa accttatacc accaactggt 1740
tttcaaaaga aaaaaattaa aagtaattca aaactttgag atataaatat aattctttaa 1800
aaactgcagc gtggttcact ggccctgtga tgggctgaat gcgcccccaa gttcatgtgg 1860
cagccttgac ccccaggacc tcagcgtgtg gcgtcttgga gacaggggct ttacagaggc 1920
gatgaaggta aaacaagctc ttatggcgac cctgacccag caggaccggt atccttatca 1980
gaaagggata tctggacaca gagacagacg tgcacgtgtg gagacacctg aagatgaaga 2040
tggcatctac caggcggggg agtggcctca ggagaaacgg gctctgccca cgcctcgacc 2100
tcggacttcc agcctccaga gccgtgtgaa aagaaacttc catcatttaa gctgccctgt 2160
ctgtgggact ttgcctcggc agcctgagca gacagtacag gctccaaaaa cgctctctgc 2220
atgtgtgatt ctggccagga ccaccctgcc cgaagccacg gctatgtcga agctaattgt 2280
gcgatttctg ccggccacgt ggttttgatc caaaagcatt tgaaagctgc tctgaagatg 2340
cagaaaagct gagtcccggc atcgctgctc cttccaagcg actgttcaca cacagggtgt 2400
gagtgcgtcc ccccatccag ggtccagcct ggcctaaggc tcactgggca ccatccagat 2460
ctgtgactgg gtccccccat ccagggtcca gcccacccga ggttcactgg gcaccatcca 2520
gaggccccag atgccgacac ctggggacgg gctgtatcag gcagatgttt cctcccgggc 2580
tccacctggg gacgggcccc ggatgctgac acctggggat gggctgtatt aggcagatgt 2640
tcctcccggg ctctagtttt ccaggccgac aggaggaagt cctgttgggg ccaggggagg 2700
cattggggat gagattgaga ggatggtggg gtcgcaaagg tttacattgc ctgtgccact 2760
ttctccaagg tctggggccg ccaccctgtg gtgcctctgg aagctgccat gtggggctgg 2820
cccacggtga ctggccacgg cggggctgtg tgtggtatgc acctgtgagc tgctgaaacg 2880
cagcctggcg gccaggaacc agctgcccca tcctctctgc aggaggtcag gtttgagcac 2940
gtattccctc aaacgctcat agacgtcagt atctcaggac aaagtgcttg tctgagaccc 3000
aggtttgggc cccaaggtgg taccatcgag ggaggcatgt tctggcaggt gacagcccct 3060
cctctgtgcc tgaacctgca gtttctgccc ccgcataaaa tgccgccatc tcaggccctc 3120
cctgaccccc aacctgcaca agggctcaca gctggcaggc acctgtgtgg ggtcgtggta 3180
ggacctgtgt ctctgaggtc cagcccaagg ctgtgccaca taggcccaaa tccaagcact 3240
cccctcctgg gcacgtggct gtgtgtgcat gtgtggctgg gtgggcaggg gggttgactc 3300
tggccaccga aatggagagg agcggtgcac tccctgggtc tggcccacgc aggctccttc 3360
ccaagtgctg ctgccgggaa atggaggtcc ctaggtgaga cgggagccgg gcactgtggg 3420
ggtggcccct gaggggctgc aggttggcac tgcccagctg acgcattccg cagtcctgca 3480
ccaggggatg aacgaggaat cggcttctgc tctgctgaac atcccactgg ttcatgtcca 3540
cttgtttggg tgatcctaac tgatctgcta cctgagtttg aatctcagcg ctattattag 3600
tcaggggtcc tggaggtggg tgaccccacc tcacctaaac cacagagatg ctcatcctca 3660
tgcatgcaca cgtccatctc agcttcagct cgcaagcagg accctcaccg tggggccacg 3720
acggaccctg caaagctggt ctgactgtgc cgagcctgtc gggggttggg ggaaggaagg 3780
cgggagctcg gcatctggag ggcagtggag accctcagcg agtgccagga ggatctgctg 3840
tcttcccagt gttgtcttca cagtggagag atgagttcac acagccttat ctgtgtttcc 3900
agtggcctct gtgtgcaaga cgggccacgg gttttgtgcg gtatttgcct gtgggtcaca 3960
gccaggtgaa tgggccctcc tggggctgca gccccaggtc ctgatgttac ttgtgccagc 4020
ctggccacag tgcccggcct ccagaagctg ctgtcagagg agcagacggg agggcagggt 4080
ggacggttaa cagggtcaag gccccagagc cccacaccct ccccagcagc cagcacaccc 4140
tctgttctgt gacctcgccc ctgcattgcg gcaactgaca gatgctcccc ggcctccttc 4200
cccgctgccg cgcaacctct gacagccacg tgtactctcc tgctttagaa caaggacctt 4260
tcccttttgt gcatgaatac gctctcagca gatgcgagaa aaaaaaaaaa aaaaaaaaa 4319
<210> 92
<211> 5205
<212> DNA
<213> Homo sapiens
<400> 92
cttttcagct gggcagctct gggaacttgg attaggtgga gaggcagttg gggggcctcg 60
ttgttttgcg tcttagttcc gccctcctgt ccatcaggag aaggaaagga taaaccctgg 120
gccatgaggc tacccctgct cctggttttt gcctctgtca ttccgggtgc tgttctccta 180
ctggacacca ggcaattttt aatctataat gaagatcaca agcgctgcgt ggatgcagtg 240
agtcccagtg ccgtccaaac cgcagcttgc aaccaggatg ccgaatcaca gaaattccga 300
tgggtgtccg aatctcagat tatgagtgtt gcatttaaat tatgcctggg agtgccatca 360
aaaacggact gggttgctat cactctctat gcctgtgact caaaaagtga atttcagaaa 420
tgggagtgca aaaatgacac acttttgggg atcaaaggag aagatttatt ttttaactac 480
ggcaacagac aagaaaagaa tattatgctc tacaagggat cgggtttatg gagcaggtgg 540
aagatctatg gaaccacaga caatctgtgc tccagaggtt atgaagccat gtatacgcta 600
ctaggcaatg ccaatggagc aacctgtgca ttcccgttca agtttgaaaa caagtggtac 660
gcagattgca cgagtgctgg gcggtcggat ggatggctct ggtgcggaac cactactgac 720
tatgacacag acaagctatt tggatattgt ccattgaaat ttgagggcag tgaaagctta 780
tggaataaag acccgctgac cagcgtttcc taccagataa actccaaatc cgctttaacg 840
tggcaccagg cgaggaaaag ctgccaacaa cagaacgctg agctcctgag catcacagag 900
attcatgagc aaacatacct gacaggatta accagttcct tgacctcagg actctggatt 960
ggacttaaca gtctgagctt caacagcggt tggcagtgga gtgaccgcag tcctttccga 1020
tatttgaact ggttaccagg aagtccatca gctgaacctg gaaaaagctg tgtgtcacta 1080
aatcctggaa aaaatgctaa atgggaaaat ctggaatgtg ttcagaaact gggctatatt 1140
tgcaaaaagg gcaacaccac tttaaattct tttgttattc cctcagaaag tgatgtgcct 1200
actcactgtc ctagtcagtg gtggccgtat gccggtcact gttacaagat tcacagagat 1260
gagaaaaaaa tccagaggga tgctctgacc acctgcagga aggaaggcgg tgacctcaca 1320
agtatccaca ccatcgagga attggacttt attatctccc agctaggata tgagccaaat 1380
gacgaattgt ggatcggctt aaatgacatt aagattcaaa tgtactttga gtggagtgat 1440
gggacccctg taacgtttac caaatggctt cgtggagaac caagccatga aaacaacaga 1500
caggaggatt gtgtggtgat gaaaggcaag gatgggtact gggcagatcg gggctgtgag 1560
tggcctcttg gctacatctg caagatgaaa tcacgaagcc aaggtccaga aatagtggaa 1620
gtcgaaaaag gctgcaggaa aggctggaaa aaacatcact tttactgcta tatgattgga 1680
catacgcttt caacatttgc agaagcaaac caaacctgta ataatgagaa tgcttattta 1740
acaactattg aagacagata tgaacaagcc ttcctgacta gtttcgttgg cttaaggcct 1800
gaaaaatatt tctggacagg actttcagat atacaaacca aagggacttt tcagtggacc 1860
atcgaggaag aggttcggtt cacccactgg aattcagata tgccagggcg aaagccaggg 1920
tgtgttgcca tgagaaccgg gattgcaggg ggcttatggg atgttttgaa atgtgatgaa 1980
aaggcaaaat ttgtgtgcaa gcactgggca gaaggagtaa cccacccacc gaagcccacg 2040
acgactcccg aacccaaatg tccggaggat tggggcgcca gcagtagaac aagcttgtgt 2100
ttcaagctgt atgcaaaagg aaaacatgag aagaaaacgt ggtttgaatc tcgagatttt 2160
tgtcgagctc tgggtggaga cttagctagc atcaataaca aagaggaaca gcaaacaata 2220
tggcgattaa taacagctag tggaagctac cacaaactgt tttggttggg attgacatat 2280
ggaagccctt cagaaggttt tacttggagt gatggttctc ctgtttcata tgaaaactgg 2340
gcttatggag aacctaataa ttatcaaaat gttgaatact gtggtgagct gaaaggtgac 2400
cctactatgt cttggaatga tattaattgt gaacacctta acaactggat ttgccagata 2460
caaaaaggac aaacaccaaa acctgagcca acaccagctc ctcaagacaa tccaccagtt 2520
actgaagatg ggtgggttat ttacaaagac taccagtatt atttcagcaa agagaaggaa 2580
accatggaca atgcgcgagc gttttgcaag aggaattttg gtgatcttgt ttctattcaa 2640
agtgaaagtg aaaagaagtt tctatggaaa tatgtaaaca gaaatgatgc acagtctgca 2700
tattttattg gtttattgat cagcttggat aaaaagtttg cttggatgga tggaagcaaa 2760
gtggattacg tgtcttgggc cacaggtgaa cccaattttg caaatgaaga tgaaaactgt 2820
gtgaccatgt attcaaattc agggttttgg aatgacatta actgtggcta tccaaacgcc 2880
ttcatttgcc agcgacataa cagtagtatc aatgctacca cagttatgcc taccatgccc 2940
tcggtcccat cagggtgcaa ggaaggttgg aatttctaca gcaacaagtg tttcaaaatc 3000
tttggattta tggaagaaga aagaaaaaat tggcaagagg cacgaaaagc ttgtataggc 3060
tttggaggga atctggtctc catacaaaat gaaaaagagc aagcatttct tacctatcac 3120
atgaaggact ccactttcag tgcctggact gggctgaatg atgtcaattc agaacacacg 3180
ttcctttgga cggatggacg aggagtccat tacacaaact gggggaaagg ttaccctggt 3240
ggaagaagaa gcagtctttc ttatgaagat gctgactgtg ttgttattat tggaggtgca 3300
tcaaatgaag caggaaaatg gatggatgat acctgcgaca gtaaacgagg ctacatatgc 3360
cagacacgat ccgacccttc cttgactaat cctccagcaa cgattcaaac agatggcttt 3420
gttaaatatg gcaaaagcag ctattcactc atgagacaaa aatttcaatg gcatgaagcg 3480
gagacatact gcaagcttca caattccctt atagccagca ttctggatcc ctacagtaat 3540
gcatttgcgt ggctgcagat ggaaacatct aatgaacgtg tgtggatcgc cctgaacagt 3600
aacttgactg ataatcaata cacttggact gataagtgga gggtgaggta cactaactgg 3660
gctgctgatg agcccaaatt gaaatcagca tgtgtttatc tggatcttga tggctactgg 3720
aagacagcac attgcaatga aagtttttac tttctctgta aaagatcaga tgaaatccct 3780
gctactgaac ccccacaact gcctggcaga tgcccggagt cagatcacac agcatggatt 3840
cctttccatg gtcactgtta ctatattgag tcctcatata caagaaactg gggccaagct 3900
tctctggaat gtcttcgaat gggttcctct ctggtttcca ttgaaagtgc tgcagaatcc 3960
agttttctgt catatcgggt tgagccactt aaaagtaaaa ccaatttttg gataggattg 4020
ttcagaaatg ttgaagggac gtggctgtgg ataaataaca gtccggtctc ctttgtcaac 4080
tggaacacag gagatccctc tggtgaacgg aatgattgtg tagctttaca tgcgtcttct 4140
gggttttgga gtaatattca ctgttcatcc tacaaaggat atatttgtaa aagaccaaaa 4200
attattgatg ctaaacctac tcatgaatta cttacaacaa aagctgacac aaggaagatg 4260
gacccttcta aaccgtcttc caacgtggcc ggagtagtca tcattgtgat cctcctgatt 4320
ttaacgggtg ctggccttgc cgcctatttc ttttataaga aaagacgtgt gcacctacct 4380
caagagggcg cctttgaaaa cactctgtat tttaacagtc agtcaagccc aggaactagt 4440
gatatgaaag atctcgtggg caatattgaa cagaatgaac actcggtcat ctagtacctc 4500
aatgcgattc tgagatattt gaatttcata aaattgtaac tgaaatttaa aatttttagt 4560
tcaatgtgat tgttttcttt aaaatgagta ctgaattgta ctggtctgtc cttttttcct 4620
ttgcctaatt gaagaaataa ttgcttgttt tctagcctgg caagatattt tcataaaaga 4680
gggataacaa tgctgattac taccttttaa aatattttag ataaatgcac agcaccacag 4740
caccacatct aagcattagt gatgggtagc tgatgtcagc ttcatgtgga ttttaagcac 4800
tctagaaaca atgaagcttc ttggcatatt ttaaggagct cccaaaatgt gttacctatt 4860
aaattgtaac tcagcaagta gaagaccatt tgaaaagtca ggtacaaatt tcctcaagtg 4920
gcataaaaat gtagtcagtt ttctctttta ccagttttta tttccactcc aattatttag 4980
aactttattt gtacatgtgc agaagaataa ggcagctgag aatcttgttt cccccaagag 5040
agttttacag gctgagtgtt gcaaatgtgt tctttgtcct gttatatgta tatcaggaat 5100
acaaggatgt gaaataaaac tgtaaatttg cataactgga tgtacttaga taatgtgaaa 5160
taaacattaa agacaaggtc tatttttaat aaaaaaaaaa aaaaa 5205
<210> 93
<211> 6736
<212> DNA
<213> Homo sapiens
<400> 93
atgggcttct tgcccaagct tctcctcctg gcctcattct tcccagcagg ccaggcctca 60
tggggcgtct ccagtcccca ggacgtgcag ggtgtgaagg ggtcttgcct gcttatcccc 120
tgcatcttca gcttccctgc cgacgtggag gtgcccgacg gcatcacggc catctggtac 180
tacgactact cgggccagcg gcaggtggtg agccactcgg cggaccccaa gctggtggag 240
gcccgcttcc gcggccgcac cgagttcatg gggaaccccg agcacagggt gtgcaacctg 300
ctgctgaagg acctgcagcc cgaggactct ggttcctaca acttccgctt cgagatcagt 360
gaggtcaacc gctggtcaga tgtgaaaggc accttggtca cagtaacaga ggagcccagg 420
gtgcccacca ttgcctcccc ggtggagctt ctcgagggca cagaggtgga cttcaactgc 480
tccactccct acgtatgcct gcaggagcag gtcagactgc agtggcaagg ccaggaccct 540
gctcgctctg tcaccttcaa cagccagaag tttgagccca ccggcgtcgg ccacctggag 600
accctccaca tggccatgtc ctggcaggac cacggccgga tcctgcgctg ccagctctcc 660
gtggccaatc acagggctca gagcgagatt cacctccaag tgaagtatgc ccccaagggt 720
gtgaagatcc tcctcagccc ctcggggagg aacatccttc caggtgagct ggtcacactc 780
acctgccagg tgaacagcag ctaccctgca gtcagttcca ttaagtggct caaggatggg 840
gtacgcctcc aaaccaagac tggtgtgctg cacctgcccc aggcagcctg gagcgatgct 900
ggcgtctaca cctgccaagc tgagaacggc gtgggctctt tggtctcacc ccccatcagc 960
ctccacatct tcatggctga ggtccaggtg agcccagcag gtcccatcct ggagaaccag 1020
acagtgacac tagtctgcaa cacacccaat gaggcaccca gtgatctccg ctacagctgg 1080
tacaagaacc atgtcctgct ggaggatgcc cactcccata ccctccggct gcacttggcc 1140
actagggctg atactggctt ctacttctgt gaggtgcaga acgtccatgg cagcgagcgc 1200
tcgggccctg tcagcgtggt agtcaaccac ccgcctctca ctccagtcct gacagccttc 1260
ctggagaccc aggcgggact tgtgggcatc cttcactgct ctgtggtcag tgagcccctg 1320
gccacactgg tgctgtcaca tgggggtcat atcctggcct ccacctccgg ggacagtgat 1380
cacagcccac gcttcagtgg tacctctggt cccaactccc tgcgcctgga gatccgagac 1440
ctggaggaaa ctgacagtgg ggagtacaag tgctcagcca ccaactccct tggaaatgca 1500
acctccaccc tggacttcca tgccaatgcc gcccgtctcc tcatcagccc ggcagccgag 1560
gtggtggaag gacaggcagt gacactgagc tgcagaagcg gcctaagccc cacacctgat 1620
gcccgcttct cctggtacct gaatggagcc ctgcttcacg agggtcccgg cagcagcctc 1680
ctgctccccg cggcctccag cactgacgcc ggctcatacc actgccgggc ccgggacggc 1740
cacagtgcca gtggcccctc ttcgccagct gttctcactg tgctctaccc ccctcgacaa 1800
ccaacattca ccaccaggct ggaccttgat gccgctgggg ccggggctgg acggcgaggc 1860
ctccttttgt gccgtgtgga cagcgacccc cccgccaggc tgcagctgct ccacaaggac 1920
cgtgttgtgg ccacttccct gccatcaggg ggtggctgca gcacctgtgg gggctgttcc 1980
ccacgcatga aggtcaccaa agcccccaac ttgctgcgtg tggagattca caaccctttg 2040
ctggaagagg agggcttgta cctctgtgag gccagcaatg ccctgggcaa cgcctccacc 2100
tcagccacct tcaatggcca ggccactgtc ctggccattg caccatcaca cacacttcag 2160
gagggcacag aagccaactt gacttgcaac gtgagccggg aagctgctgg cagccctgct 2220
aacttctcct ggttccgaaa tggggtgctg tgggcccagg gtcccctgga gaccgtgaca 2280
ctgctgcccg tggccagaac tgatgctgcc ctttacgcct gccgcatcct gactgaggct 2340
ggtgcccagc tctccactcc cgtgctcctg agtgtactct atcccccgga ccgtccaaag 2400
ctgtcagccc tcctagacat gggccagggc cacatggctc tgttcatctg cactgtggac 2460
agccgccccc tggccttgct ggccttgttc catggggagc acctcctggc caccagcctg 2520
ggtccccagg tcccatccca tggtcggttc caggctaaag ctgaggccaa ctccctgaag 2580
ttagaggtcc gagaactggg ccttggggac tctggcagct accgctgtga ggccacaaat 2640
gttcttggat catccaacac ctcactcttc ttccaggtcc gaggagcctg ggtccaggtg 2700
tcaccatcac ctgagctcca agagggccag gctgtggtcc tgagctgcca ggtacacaca 2760
ggagtcccag aggggacctc atatcgttgg tatcgggatg gccagcccct ccaggagtcg 2820
acctcggcca cgctccgctt tgcagccata actttgacac aagctggggc ctatcattgc 2880
caagcccagg ccccaggctc agccaccacg agcctagctg cacccatcag cctccacgtg 2940
tcctatgccc cacgccacgt cacactcact accctgatgg acacaggccc tggacgactg 3000
ggcctcctcc tgtgccgtgt ggacagtgac cctccggccc agctgcggct gctccacggg 3060
gatcgccttg tggcctccac cctacaaggt gtggggggac ccgaaggcag ctctcccagg 3120
ctgcatgtgg ctgtggcccc caacacactg cgtctggaga tccacggggc tatgctggag 3180
gatgagggtg tctatatctg tgaggcctcc aacaccctgg gccaggcctc ggcctcagct 3240
gacttcgacg ctcaagctgt gaatgtgcag gtgtggcccg gggctaccgt gcgggagggg 3300
cagctggtga acctgacctg ccttgtgtgg accactcacc cggcccagct cacctacaca 3360
tggtaccagg atgggcagca gcgcctggat gcccactcca tccccctgcc caacgtcaca 3420
gtcagggatg ccacctccta ccgctgcggt gtgggccccc ctggtcgggc accccgcctc 3480
tccagaccta tcaccttgga cgtcctctac gcgccccgca acctgcgcct gacctacctc 3540
ctggagagcc atggcgggca gctggccctg gtactgtgca ctgtggacag ccgcccgccc 3600
gcccagctgg ccctcagcca cgccggtcgc ctcttggcct cctcgacagc agcctctgtc 3660
cccaacaccc tgcgcctgga gctgcgaggg ccacagccca gggatgaggg tttctacagc 3720
tgctctgccc gcagccctct gggccaggcc aacacgtccc tggagctgcg gctggagggt 3780
gtgcgggtga tcctggctcc ggaggctgcc gtgcctgaag gtgcccccat cacagtgacc 3840
tgtgcggacc ctgctgccca cgcacccaca ctctatactt ggtaccacaa cggtcgttgg 3900
ctgcaggagg gtccagctgc ctcactctca ttcctggtgg ccacgcgggc tcatgcaggc 3960
gcctactctt gccaggccca ggatgcccag ggcacccgca gctcccgtcc tgctgccctg 4020
caagtcctct atgcccctca ggacgctgtc ctgtcctcct tccgggactc cagggccaga 4080
tccatggctg tgatacagtg cactgtggac agtgagccac ctgctgagct ggccctatct 4140
catgatggca aggtgctggc cacgagcagc ggggtccaca gcttggcatc agggacaggc 4200
catgtccagg tggcccgaaa cgccctacgg ctgcaggtgc aagatgtgcc tgcaggtgat 4260
gacacctatg tttgcacagc ccaaaacttg ctgggctcaa tcagcaccat cgggcggttg 4320
caggtagaag gtgcacgcgt ggtggcagag cctggcctgg acgtgcctga gggcgctgcc 4380
ctgaacctca gctgccgcct cctgggtggc cctgggcctg tgggcaactc cacctttgca 4440
tggttctgga atgaccggcg gctgcacgcg gagcctgtgc ccactctcgc cttcacccac 4500
gtggctcgtg ctcaagctgg gatgtaccac tgcctggctg agctccccac tggggctgct 4560
gcctctgctc cagtcatgct ccgtgtgctc taccctccca agacgcccac catgatggtc 4620
ttcgtggagc ctgagggtgg cctccggggc atcctggatt gccgagtgga cagcgagccg 4680
ctcgccagcc tgactctcca ccttggcagt cgactggtgg cctccagtca gccccagggt 4740
gctcctgcag agccacacat ccatgtcctg gcttccccca atgccctgag ggtggacatc 4800
gaggcgctga ggcccagcga ccaaggggaa tacatctgtt ctgcctcaaa tgtcctgggc 4860
tctgcctcta cctccaccta ctttggggtc agagccctgc accgcctgca tcagttccag 4920
cagctgctct gggtcctggg actgctggtg ggcctcctgc tcctgctgtt gggcctgggg 4980
gcctgctaca cctggagaag gaggcgtgtt tgtaagcaga gcatgggcga gaattcggtg 5040
gagatggctt ttcagaaaga gaccacgcag ctcattgatc ctgatgcagc cacatgtgag 5100
acctcaacct gtgccccacc cctgggctga ccagtggtgt tgcctgccct ccggaggaga 5160
aagtggccag aatctgtgat gactccagcc tatgaatgtg aatgaggcag tgttgagtcc 5220
tgcccgcctc tacgaaaaca gctctgtgac atctgacttt ttatgacctg gccccaagcc 5280
tcttgccccc ccaaaaatgg gtggtgagag gtctgcccag gagggtgttg accctggagg 5340
acactgaaga gcactgagct gatctcgctc tctcttctct ggatctcctc ccttctctcc 5400
atttctccct caaaggaagc cctgcccttt cacatccttc tcctcgaaag tcaccctgga 5460
ctttggttgg attgcagcat cctgcatcct cagaggctca ccaaggcatt ctgtattcaa 5520
cagagtatca gtcagcctgc tctaacaaga gaccaaatac agtgacttca acatgataga 5580
attttatttt tctctcccac gctagtctgg ctgttacgat ggtttatgat gttggggctc 5640
aggatccttc tatcttcctt ttctctatcc ctaaaatgat gcctttgatt gtgaggctca 5700
ccatggcccc gctttgtcca catgccctcc agccagaaga aggaagagtg gaggtagaag 5760
cacacccatg cccatggtgg acgcaactca gaagctgcac aggacttttc cactcacttc 5820
ccattggctg gagtattgtc acatggctac tgcaagctac aagggagact gggaaatgta 5880
gtttttattt tgagtccaga ggacatttgg aattggactt ccaaaggact cccaactgtg 5940
agctcatccc tgagactttt gacattgttg ggaatgccac cagcaggcca tgttttgtct 6000
cagtgcccat ctactgaggg ccagggtgtg cccctggcca ttctggttgt gggcttcctg 6060
gaagaggtga tcactctcac actaagactg aggaaataaa aaaggtttgg tgttttccta 6120
gggagagagc atgccaggca gtggagttgc ctaagcagac atccttgtgc cagatttggc 6180
ccctgaaaga agagatgccc tcattcccac caccaccccc cctaccccca gggactgggt 6240
actaccttac tggcccttac aagagtggag ggcagacaca gatgttgtca gcatccttat 6300
tcctgctcca gatgcatctc tgttcatgac tgtgtgagct cctgtccttt tcctggagac 6360
cctgtgtcgg gctgttaaag agaatgagtt accaagaagg aatgacgtgc ccctgcgaat 6420
cagggaccaa caggagagag ctcttgagtg ggctagtgac tccccctgca gcctggtgga 6480
gatggtgtga ggagcgaaga gccctctgct ctaggatttg ggttgaaaaa cagagagaga 6540
agtggggagt tgccacagga gctaacacgc tgggaggcag ttgggggcgg gtgaactttg 6600
tgtagccgag gccgcaccct ccctcattcc aggctcattc attttcatgc tccattgcca 6660
gactcttgct gggagcccgt ccagaatgtc ctcccaataa aactccatcc tatgacgcaa 6720
aaaaaaaaaa aaaaaa 6736
<210> 94
<211> 1490
<212> DNA
<213> Homo sapiens
<400> 94
gcagttcctg agagaagaac cctgaggaac agacgttccc tcgcggccct ggcacctcca 60
accccagata tgctgctgct gctgctgctg cccctgctct gggggaggga gagggtggaa 120
ggacagaaga gtaaccggaa ggattactcg ctgacgatgc agagttccgt gaccgtgcaa 180
gagggcatgt gtgtccatgt gcgctgctcc ttctcctacc cagtggacag ccagactgac 240
tctgacccag ttcatggcta ctggttccgg gcagggaatg atataagctg gaaggctcca 300
gtggccacaa acaacccagc ttgggcagtg caggaggaaa ctcgggaccg attccacctc 360
cttggggacc cacagaccaa aaattgcacc ctgagcatca gagatgccag aatgagtgat 420
gcggggagat acttctttcg tatggagaaa ggaaatataa aatggaatta taaatatgac 480
cagctctctg tgaacgtgac agaccctcct cagaacttga ctgtgactgt cttccaagga 540
gaaggcacag catccacagc tctggggaac agctcatctc tttcagtcct agagggccag 600
tctctgcgct tggtctgtgc tgttgacagc aatccccctg ccaggctgag ctggacctgg 660
aggagtctga ccctgtaccc ctcacagccc tcaaaccctc tggtactgga gctgcaagtg 720
cacctggggg atgaagggga attcacctgt cgagctcaga actctctggg ttcccagcac 780
gtttccctga acctctccct gcaacaggag tacacaggca aaatgaggcc tgtatcagga 840
gtgttgctgg gggcggtcgg gggagctgga gccacagccc tggtcttcct ctccttctgt 900
gtcatcttca ttgtagtgag gtcctgcagg aagaaatcgg caaggccagc agcggacgtg 960
ggagacatag gcatgaagga tgcaaacacc atcaggggct cagcctctca gggtaacctg 1020
actgagtcct gggcagatga taacccccga caccatggcc tggctgccca ctcctcaggg 1080
gaggaaagag agatccagta tgcacccctc agctttcata agggggagcc tcaggaccta 1140
tcaggacaag aagccaccaa caatgagtac tcagagatca agatccccaa gtaagaaaat 1200
gcagaggctc gggcttgttt gagggttcac gacccctcca gcaaaggagt ctgaggctga 1260
ttccagtaga attagcagcc ctcaatgctg tgcaacaaga catcagaact tattcctctt 1320
gtctaactga aaatgcatgc ctgatgacca aactctccct ttccccatcc aatcggtcca 1380
cactccccgc cctggcctct ggtacccacc attctcctct gtacttctct aaggatgact 1440
actttagatt ccgaatatag tgagattgta acgtgaaaaa aaaaaaaaaa 1490
<210> 95
<211> 935
<212> DNA
<213> Homo sapiens
<400> 95
acttcctgca gaaatcctcc agccctgtta gaaatgcctc agccaggggg actcatctcc 60
tcaaacctgg gggaccgaga cctatgagag gtcacagcat gagccaggac atcggaggta 120
cccagacatt gttatgaaac tccgcatgtg cccctggtgg acgctgctgg acccagcatg 180
cacacttctc ggctaagagt caccctggat gaaccaccat tgccagcggg gagcatgttg 240
cagctttccc acgcagtgga tgagaacgaa ggttacgacc attgtgtggg aggcgtctgt 300
gtagcaattg ctggaatcac ttgtggcatt gtagaaagac tgagcgtggg aaagaagacg 360
cattctgaag tcaccccgat ttatgttaaa ttatcacctt gactactgct atagaacgaa 420
tgtttatgtc ccccacccaa attcgtatgc taagacctaa tagccaataa gatagtatta 480
atagatgggg cctttgggag gtgagtggct catgagggca gagtcctcaa aaccagataa 540
gtgcccgaat aaaaggggcc ccagagagat cccttgcacc gtctaccatg tgaagtgtag 600
aacacagcga gaaggccacc tatgagccag aacgtgggcc ctcaccagaa cccagttgtg 660
ctggcaccct gatcctggac ttccagcctc caaaatgacg acaaagaagt ttgtttttcc 720
tgagccatcc acttcaaagt attctgtcat agctccccaa atagactaag acatctactt 780
aaccttggtc aaacgtttaa ccttggagtc cacgcctctg aaatggtgac aataacactg 840
tgtatttcct actttatgat caggattaat aaatgtaatt tattaatcag aaattagtaa 900
tttctgatta ttaaaaaaaa aaaaaaaaaa aaaaa 935
<210> 96
<211> 1375
<212> DNA
<213> Homo sapiens
<400> 96
ggacagcaga gacaacagtc acagtaaccc tgtctagagc gttcctggag cccaagctcc 60
tctccacaga ggaggacaga gcaggcagca gagaccatgg ggcccccctc agcttgtccc 120
cacagagaat gcatcccctg gcaggggctc ttgctcacag cctcactttt aactttctgg 180
aacgcaccca ccactgcctg gctctttatt gcatcagcgc cctttgaagt tgctgaaggg 240
gagaatgttc atctctctgt ggtttatctg cccgagaatc tttacagcta tggctggtac 300
aaagggaaaa cggtggagcc caaccagcta atcgcagcat atgtaataga cactcacgtt 360
aggactccag ggcctgcata cagcggtcga gagacaatat cacccagtgg agatctgcat 420
ttccagaacg tcaccctaga ggacacggga tactacaacc tacaagtcac atacagaaat 480
tctcagattg aacaggcatc tcaccatctc cgtgtatacg agtcagtggc tcagccctcc 540
atccaagcca gcagcaccac agtcacagag aagggctccg tggtcctgac ctgccacaca 600
aataacactg gaacctcttt ccagtggatt ttcaacaacc agcgtctgca ggtcacgaag 660
aggatgaagc tgtcctggtt taaccatgtg ctcaccatag accccatcag gcaggaggac 720
gctggggagt atcagtgtga ggtctccaac ccagtcagct ccaacaggag cgaccccctc 780
aagctgactg taaaatatga caacactcta ggcatcctga tcggggtcct ggttgggagt 840
cttctggtgg ctgcacttgt gtgtttcctg ctcctccgaa aaactggcag ggccagcgat 900
cagagtgact tcagggagca gcagccccca gcctccaccc ccggccatgg accctctgac 960
agctccatct cctaggaatt gctacactct gacacaaaca tttactgctg gatcgaccac 1020
aaagcagatg tggcttctta ggttcctctg ggagctgctc ctgtgggttg atggagcgtc 1080
cctgaagccc ccagccctgg ggatggggaa ggacatggag cctgagccag agaaccagct 1140
ctgagtcctg aggagacaca ggcctgggga caggaaggga tgggggtccc tgctgaatat 1200
atagagacct caacagactg ccccgggctc tgggtgggcc aaggcgaagg cttcccatca 1260
ccacaggaag tgggggcttg cagggaaagt gaatgggcct atggcccacc cggggtcacc 1320
tggaaaggat ctgaataaag gggaaacttc ctctcaaaaa aaaaaaaaaa aaaaa 1375
<210> 97
<211> 2082
<212> DNA
<213> Homo sapiens
<400> 97
accacacaga cacacacctc cttgctggag cattcactag gcgaggcgct ccatcggact 60
cactagccgc actcatgaat cggcaccatc tgcaggatca ctttctggaa atagacaaga 120
agaactgctg tgtgttccga gatgacttca ttgtcaaggt gttgccgccg gtgttggggc 180
tggagtttat cttcgggctt ctgggcaatg gccttgccct gtggattttc tgtttccacc 240
tcaagtcctg gaaatccagc cggattttcc tgttcaacct ggcagtggct gactttctac 300
tgatcatctg cctgcccttc ctgatggaca actatgtgag gcgttgggac tggaagtttg 360
gggacatccc ttgccggctg atgctcttca tgttggctat gaaccgccag ggcagcatca 420
tcttcctcac ggtggtggcg gtagacaggt atttccgggt ggtccatccc caccacgccc 480
tgaacaagat ctccaatcgg acagcagcca tcatctcttg ccttctgtgg ggcatcacta 540
ttggcctgac agtccacctc ctgaagaaga agatgccgat ccagaatggc ggtgcaaatt 600
tgtgcagcag cttcagcatc tgccatacct tccagtggca cgaagccatg ttcctcctgg 660
agttcttcct gcccctgggc atcatcctgt tctgctcagc cagaattatc tggagcctgc 720
ggcagagaca aatggaccgg catgccaaga tcaagagagc catcaccttc atcatggtgg 780
tggccatcgt ctttgtcatc tgcttccttc ccagcgtggt tgtgcggatc cgcatcttct 840
ggctcctgca cacttcgggc acgcagaatt gtgaagtgta ccgctcggtg gacctggcgt 900
tctttatcac tctcagcttc acctacatga acagcatgct ggaccccgtg gtgtactact 960
tctccagccc atcctttccc aacttcttct ccactttgat caaccgctgc ctccagagga 1020
agatgacagg tgagccagat aataaccgca gcacgagcgt cgagctcaca ggggacccca 1080
acaaaaccag aggcgctcca gaggcgttaa tggccaactc cggtgagcca tggagcccct 1140
cttatctggg cccaacctct ccttaaataa ccatgccaag aagggacatt gtcaccaaga 1200
accaggatct ctggagaaac agttgggctg ttgcatcgag taatgtcact ggactcggcc 1260
taaggtttcc tggaacttcc agattcagag aatgcgattt agggaaacgg tggcagatga 1320
gtgggagact ggttgcaagg tgtgaccgca ggaatcctgg aggaatagag agtaaagctt 1380
ctaggcatct gaaacttttg cttcatctct gacgctcgca ggactgaaga tgggcaaatt 1440
gtaggcattt ctgctgagca gagttggagc cagagatcta cttgtgactt gttggccttc 1500
ttcccacatc tgcctcagac tggagggggc tcagctcctg gggtgatatc tagcctgctt 1560
gtgagctcta gcagggataa ggagagctga gattggaggg aattgtgttg ctcctggagg 1620
gagcccaggc atcattaaac aagccagtag gtcacctggc ttccgtggac caattcatct 1680
ttcagacaag ctttagcaga aatggactca gggaagagac tcacacgctt tggttaatat 1740
ctgtgtttcc ggtgggtgta ataggggatt agccccagaa gggactgagc taaacagtgt 1800
tattatggga aaggaaatgg cattgctgct ttcaaccagc gactaatgca atccattcct 1860
ctcttgttta tagtaatcta agggttgggc agttaaaacg gcttcaggat agaaagctgt 1920
ttcccacctc tgtttgcttt taacattaaa agggaaatgt gcctctgccc cacagttaga 1980
ggggtgcacg ttcctcctgg ttccttcgct tgtgtttctg tacttaccaa aaatctacca 2040
tttcaataaa ttttgatagg agacaaaaaa aaaaaaaaaa aa 2082
<210> 98
<211> 3019
<212> DNA
<213> Homo sapiens
<400> 98
cccagccctc gtcgccgccg ccattttagc tgttggttcc ggccgcaccg tgtgggctgt 60
agtagcggga ggggtggggg tcctccagag ttaagtggct gtcctcgact gtgcccatac 120
agcagccagc tttcttcctt aataactgcc cgttcgaaga gtgcgaggat gtccaagcgg 180
caccggttgg acctagggga ggattacccc tctggcaaga agcgtgcggg gaccgatggg 240
aaggatcgag atcgagaccg ggatcgtgaa gatcggtcta aagatcgaga ccgagaacgt 300
gatagaggag atagagagcg agagagggag aaagaaaagg agaaggagtt gcgagcttca 360
acaaatgcta tgcttatcag tgctggatta ccacctttga aagcttccca ttcagctcac 420
tcaacccact cagcacattc aacgcattca acacattctg ctcattcaac gcatgccgga 480
catgcaggtc acacgtcact tccacagtgc attaatccgt tcaccaactt accccatact 540
cctcgatact atgatattct aaagaaacgt cttcagctcc ctgtttggga atacaaggat 600
aggtttacag atattctggt tagacatcag tcctttgtac tggttggtga gactgggtct 660
ggtaaaacaa cacagattcc acagtggtgt gtggagtaca tgcgatcatt accaggaccc 720
aagagaggag ttgcctgtac ccaacccagg agagtggctg caatgagtgt ggctcagaga 780
gttgctgatg agatggatgt gatgttgggc caggaagttg gttactccat tcgatttgaa 840
gactgcagta gtgcaaaaac cattcttaag tatatgactg atgggatgtt acttcgtgaa 900
gctatgaatg atcccctcct ggagcgttat ggtgtaataa ttcttgatga ggctcatgag 960
aggacactgg ctacagatat tctaatgggt gttctgaagg aagttgtaag acagagatca 1020
gatttaaagg ttatagttat gagcgctact ctagatgcag gaaaattcca gatttacttt 1080
gataactgtc ctctcctaac tattcctggg cgtacacatc ctgttgagat cttctatact 1140
ccagaaccag agagagatta tcttgaagca gcaattcgaa cagttatcca gattcatatg 1200
tgtgaagagg aagagggaga tcttcttctt ttcttaactg gtcaagagga aattgatgaa 1260
gcctgtaaga gaataaagcg tgaagttgat gatttgggcc ctgaagttgg tgacattaaa 1320
atcattccat tgtattctac acttccacct cagcagcagc aacgcatttt tgagcctcca 1380
cctcccaaaa aacagaatgg agcaattgga agaaaggtag ttgtgtcaac taacatagca 1440
gagacgtctt tgacaataga tggtgtggtg tttgtgattg atcctggatt tgcgaaacag 1500
aaggtctaca atcctcgaat cagagttgag tcccttttgg tgacagctat tagtaaagct 1560
tcagctcagc aaagggctgg tcgagctgga cgtaccagac ctggaaaatg cttcagactt 1620
tacacagaga aagcttataa aacagaaatg caggataaca cctatcctga gattttgcgt 1680
tctaatttag gatcagttgt gttacaattg aagaaacttg gtattgatga cttggtacat 1740
tttgatttta tggatccacc agctcctgaa actctgatga gagccctgga acttttgaat 1800
tacctggctg ctttaaatga tgatggagat ctgactgaat tgggatccat gatggcagag 1860
tttcctctag atccacagct cgcaaaaatg gttattgcaa gttgtgacta caactgttct 1920
aatgaggtcc tatctattac tgctatgttg tcagtcccac agtgttttgt tcgccccacg 1980
gaggccaaga aagccgcaga tgaggccaag atgagatttg cccacataga tggagatcat 2040
ctgacactgc tgaacgtcta ccatgctttt aaacaaaatc atgaatcggt tcagtggtgt 2100
tatgacaact tcattaacta caggtccctg atgtccgcag acaatgtacg ccagcagcta 2160
tctcgaatta tggacagatt taatttgcct cgtcgaagta ctgactttac aagcagggac 2220
tattatatta atataagaaa agctttggtt actgggtatt ttatgcaggt ggcacattta 2280
gaacgaacag ggcattactt aactgtgaaa gataaccagg tggttcagtt gcatccctct 2340
actgttcttg accacaaacc tgaatgggtg ctttataatg agtttgttct aacaacaaag 2400
aattacatcc ggacatgtac agatatcaag ccagaatggt tggtgaaaat tgcccctcaa 2460
tattatgaca tgagcaattt cccacagtgt gaagcaaaga gacagttgga ccgcatcatt 2520
gccaaacttc aatccaagga atattcacag tactgaattc agtgcttaga actgaagtta 2580
ttgagaggac agctttaaaa gatgaatgaa ctcaaaagtt cgagttgtgc tcttcacgtt 2640
ggttcgataa tggcctttat ttgaaagctt tttaattttt ctttacagta aatattccat 2700
tctgatttca taaattaaac atttatgcct cccttttgtg ttgacactgt agctcatact 2760
ggaaaagtcg atcaatgttt tgcagtttat tgaaagtagt tctatatata acaatgttat 2820
aagcatttct ttagaaatgg ttgaaaatgc ttctaaaatg tgattatcga ccatggtatg 2880
catgatcgtt gtaattgttg acattccttt tagaagttgt gaaatgttac aacttgtgct 2940
tatgtagaca caatcttctg tctcagtaca gaggcactga cttcaataaa gtctatttat 3000
actaattttg gccaaaaaa 3019
<210> 99
<211> 1865
<212> DNA
<213> Homo sapiens
<400> 99
gggcagctcc accctgggag ggactgtggc ccaggtactg cccgggtgct actttatggg 60
cagcagctca gttgagttag agtctggaag acctcagaag acctcctgtc ctatgaggcc 120
ctccccatgg ctttagctga cttgtatgaa gaaggaggtg gaggaggagg agaaggtgaa 180
gacaatgctg actcaaagga gacgatctgc cgaccctctg ggagaaaatc cagcaagatg 240
caagccttca gaatctggga tgttaaccag aagaccttct atctgaggaa caaccaacta 300
gttgctggat acttgcaagg accaaatgtc aatttagaag aaaagataga tgtggtaccc 360
attgagcctc atgctctgtt cttgggaatc catggaggga agatgtgcct gtcctgtgtc 420
aagtctggtg atgagaccag actccagctg gaggcagtta acatcactga cctgagcgag 480
aacagaaagc aggacaagcg cttcgccttc atccgctcag acagtggccc caccaccagt 540
tttgagtctg ccgcctgccc cggttggttc ctctgcacag cgatggaagc tgaccagccc 600
gtcagcctca ccaatatgcc tgacgaaggc gtcatggtca ccaaattcta cttccaggag 660
gacgagtagt actgcccagg cctgcctgtt cccattcttg catggcaagg actgcaggga 720
ctgccagtcc ccctgcccca gggctcccgg ctatgggggc actgaggacc agccattgag 780
gggtggaccc tcagaaggcg tcacaacaac ctggtcacag gactctgcct cctcttcaac 840
tgaccagcct ccatgctgcc tccagaatgg tctttctaat gtgtgaatca gagcacagca 900
gcccctgcac aaagcccttc catgtcgcct ctgcattcag gatcaaaccc cgaccacctg 960
cccaacctgc tctcctcttg ccactgcctc ttcctccctc attccacctt cccatgccct 1020
ggatccatca ggccacttga tgacccccaa ccaagtggct cccacaccct gttttacaaa 1080
aaagaaaaga ccagtccatg agggaggttt ttaagggttt gtggaaaatg aaaattagga 1140
tttcatgatt tttttttttc agtccccgtg aaggagagcc cttcatttgg agattatgtt 1200
ctttcgggga gaggctgagg acttaaaata ttcctgcatt tgtgaaatga tggtgaaagt 1260
aagtggtagc ttttcccttc tttttcttct ttttttgtga tgtcccaact tgtaaaaatt 1320
aaaagttatg gtactatgtt agccccataa tttttttttt ccttttaaaa cacttccata 1380
atctggactc ctctgtccag gcactgctgc ccagcctcca agctccatct ccactccaga 1440
ttttttacag ctgcctgcag tactttacct cctatcagaa gtttctcagc tcccaaggct 1500
ctgagcaaat gtggctcctg ggggttcttt cttcctctgc tgaaggaata aattgctcct 1560
tgacattgta gagcttctgg cacttggaga cttgtatgaa agatggctgt gcctctgcct 1620
gtctccccca ccgggctggg agctctgcag agcaggaaac atgactcgta tatgtctcag 1680
gtccctgcag ggccaagcac ctagcctcgc tcttggcagg tactcagcga atgaatgctg 1740
tatatgttgg gtgcaaagtt ccctacttcc tgtgacttca gctctgtttt acaataaaat 1800
cttgaaaatg cctaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1860
aaaaa 1865
<210> 100
<211> 1132
<212> DNA
<213> Homo sapiens
<400> 100
agaagcagtc agcccagggc tctcggatgc agggagcctg ggcccaaaca gcagcttccg 60
gagtcggaag gagctgagga agaagactga ctgaaggagc ttgcgacttt tccgcctcgg 120
caaccggacc cagcagcaag caggacgggc ggcgctctgc tactggtccc gttaagccag 180
agtagcccaa gccctgaagt cactgctcat ccggaatgga aatcccgccg accaactacc 240
cagcctccag ggcggccttg gtggcacaga actacatcaa ctaccagcag gggaccccgc 300
acagggtgtt tgaggtgcag aaggtcaaac aagccagcat ggaggatatt ccaggaagag 360
gacataagta tcaccttaaa tttgctgttg aagaaattat acaaaaacaa gttaaggtga 420
actgcacagc tgaagtactt tacccttcaa cgggacaaga aactgcacca gaagtcaact 480
tcacatttga aggagaaact ggaaagaatc cagatgaaga agacaacaca ttttatcaaa 540
gacttaagtc catgaaggaa ccgctagaag cacaaaatat tccagacaat tttggaaatg 600
tatctccaga aatgacgctc gttctacatt tagcctgggt tgcctgtggt tatataatat 660
ggcaaaattc tactgaagac acatggtata aaatggtaaa aattcaaact gtcaagcaag 720
tgcaaagaaa tgatgacttt attgaattag actacaccat tctacttcat aatatagcat 780
ctcaggagat tattccctgg caaatgcaag ttctctggca tccacaatac ggcactaaag 840
taaaacataa tagccgtctg ccaaaggaag tacaactgga ataaacaaaa accctaacac 900
tggaagtgta aacatgtcta ttgatgtgta tgccaatttc actggcatct agcttatgag 960
gccaaataat cccaaagtgt cactttatat aaatgtcttg attacagtat agaactttat 1020
agagtccata atacaaagta tcactacata aaaatgtctt taaaacagta atagtggtat 1080
gtatatccaa aataaaaagc ttcaatttca gcctcaaaaa aaaaaaaaaa aa 1132
<210> 101
<211> 466
<212> DNA
<213> Homo sapiens
<400> 101
accactgctg gctttttgct gtagctccac attcctgtgc attgaggggt taacattagg 60
ctgggaagat gacaaaactt gaagagcatc tggagggaat tgtcaatatc ttccaccaat 120
actcagttcg gaaggggcat tttgacaccc tctctaaggg tgagctgaag cagctgctta 180
caaaggagct tgcaaacacc atcaagaata tcaaagataa agctgtcatt gatgaaatat 240
tccaaggcct ggatgctaat caagatgaac aggtcgactt tcaagaattc atatccctgg 300
tagccattgc gctgaaggct gcccattacc acacccacaa agagtaggta gctctctgaa 360
ggctttttac ccagcaatgt cctcaatgag ggtcttttct ttccctcacc aaaacccagc 420
cttgcccgtg gggagtaaga gttaataaac acactcacga aaagtt 466
<210> 102
<211> 1170
<212> DNA
<213> Homo sapiens
<400> 102
cttttctcag gaccatcagt caggctcttt gtgtctagga gcctcctaat gcagtcttct 60
gcacagtcct ggggactgac tgactgaatc acacctctgg ggctgggggc tgctgacatg 120
tgtgcctttc cttggctgct tcttctcctg ctgctccagg agggcagcca aaggagactc 180
tggagatggt gtggatccga ggaagtggtt gcggtccttc aggagtccat cagcctcccc 240
ctggaaatac caccagatga agaggttgag aacatcatct ggtcctctca caaaagtctt 300
gccactgtgg tgccagggaa agagggacat ccagctacca tcatggtgac caatccacac 360
taccagggcc aagtgagctt cctggacccc agctattccc tgcatatcag caatctgagc 420
tgggaggatt cagggcttta ccaagctcaa gtcaacctga gaacatccca gatctctacc 480
atgcagcagt acaatatatg tgtctaccga tggctgtcag agccccagat cactgtgaac 540
tttgagagtt ctggggaagg tgcctgcagt atgtccctgg tgtgctctgt ggagaaggca 600
ggcatggata tgacctacag ctggctctcc cggggggata gcacttatac attccatgaa 660
ggccctgtcc tcagcacatc ctggaggccg ggggacagtg ccctctccta cacctgcaga 720
gccaacaacc ccatcagcaa cgtcagttct tgccccatcc ctgatgggcc cttctatgca 780
gatcctaact atgcttctga gaagccttca acagccttct gcctcctggc caagggattg 840
ctcatcttct tgctcttggt aattctggcc atgggactct gggtcatccg agtccagaaa 900
agacacaaaa tgccaaggat gaagaaactc atgagaaaca gaatgaaatt gaggaaggag 960
gcaaagcctg gctccagccc tgcctgactg ctccttggga accccagtcc tgagcttggt 1020
ttcttcccag cacccagaga atccttcctc agctctcttc tttccagggg aaggaggtgc 1080
tcaggggtgg gtatccagag agccatactt ctgagggaag actggctggc aataaagtca 1140
aattaagtga ccacaaaaaa aaaaaaaaaa 1170
<210> 103
<211> 2113
<212> DNA
<213> Homo sapiens
<400> 103
actcaccctc cggcttcctg tcggggcttt ctcagcccca ccccacgttt ggacatttgg 60
agcatttcct tccctgacag ccggacctgg gactgggctg gggccctggc ggatggagac 120
atgctgcccc tgctgctgct gcccctgctg tggggggggt ccctgcagga gaagccagtg 180
tacgagctgc aagtgcagaa gtcggtgacg gtgcaggagg gcctgtgcgt ccttgtgccc 240
tgctccttct cttacccctg gagatcctgg tattcctctc ccccactcta cgtctactgg 300
ttccgggacg gggagatccc atactacgct gaggttgtgg ccacaaacaa cccagacaga 360
agagtgaagc cagagaccca gggccgattc cgcctccttg gggatgtcca gaagaagaac 420
tgctccctga gcatcggaga tgccagaatg gaggacacgg gaagctattt cttccgcgtg 480
gagagaggaa gggatgtaaa atatagctac caacagaata agctgaactt ggaggtgaca 540
gccctgatag agaaacccga catccacttt ctggagcctc tggagtccgg ccgccccaca 600
aggctgagct gcagccttcc aggatcctgt gaagcgggac cacctctcac attctcctgg 660
acggggaatg ccctcagccc cctggacccc gagaccaccc gctcctcgga gctcaccctc 720
acccccaggc ccgaggacca tggcaccaac ctcacctgtc aggtgaaacg ccaaggagct 780
caggtgacca cggagagaac tgtccagctc aatgtctcct atgctccaca gaacctcgcc 840
atcagcatct tcttcagaaa tggcacaggc acagccctgc ggatcctgag caatggcatg 900
tcggtgccca tccaggaggg ccagtccctg ttcctcgcct gcacagttga cagcaacccc 960
cctgcctcac tgagctggtt ccgggaggga aaagccctca atccttccca gacctcaatg 1020
tctgggaccc tggagctgcc taacatagga gctagagagg gaggggaatt cacctgccgg 1080
gttcagcatc cgctgggctc ccagcacctg tccttcatcc tttctgtgca gagaagctcc 1140
tcttcctgca tatgtgtaac tgagaaacag cagggctcct ggcccctcgt cctcaccctg 1200
atcagggggg ctctcatggg ggctggcttc ctcctcacct atggcctcac ctggatctac 1260
tataccaggt gtggaggccc ccagcagagc agggctgaga ggcctggctg agcccctccc 1320
gctcaagaca gaactgaggt gtggacactt agccctgtgg gacacatgca ggacatcact 1380
gtcagcttct ttctggaagc tcacatccca ctgactaccc ctcttttcct tcctgcccca 1440
taccccttct acttattccc ctctgcttgt gagtcttgcc ccaccacacc tgcatcccca 1500
tctgcacccc atcccctctc cacctgccct tctcttccct ctccatccac catctccagc 1560
cctgtgaagg gaatgtactt tcggtcttat acccccatta cccattaccc aaaagttacc 1620
tttttttttt tttttttttt ttgagacaga gtctcactct gttgcacagg ctggagttca 1680
gtggcacaat ctccgttcac tgcaacctcc acctctgggg ttcaagcaat tctcctgcct 1740
cagcctccct agtagctggg attacaggtg cctgccacca catccagtta attttttttt 1800
tttgtatgtt agtagagatg gggttttacc atgttggcca ggtctcgaac tcctgacctc 1860
aagcaatcca ctgcattggc ctcccaaagt gctggcatta caggtatgag ccaccgtgcc 1920
tggctgccaa aagttacctt cttaacactt gaatttctgg tctcctcagc ttccctatcc 1980
atataggcac agagaggcag catttgtttt ccagttaaaa ctctacctca ttgtgattat 2040
tatccaatac aattgttaca aaataagtaa aacttttatg aaacaataca acataactga 2100
ttttactctt taa 2113
<210> 104
<211> 660
<212> DNA
<213> Homo sapiens
<400> 104
ttggcaacac cattatgaca tcacaaccta tttccaatga gaccatcata atgctcccat 60
caaatgtcat caacttctcc caagcagaga aacccgaacc caccaaccag gggcaggata 120
gcctgaagaa acgtctacag gcaaaagtca aagttattgg ggtgcatagc agcctggctg 180
gaagcattct gagtgctctg tctgccctgg tgggtttcat tctcctgtct gtcaacccgg 240
ctgcattaaa tcctgcctca ttgcagtgta agttggacga aaaggatata ccaaccagac 300
ttcttctttc ttatgattat cattcacctt acaccatgga ctgccataga gccaaagcca 360
gtctggctgg aactctgtct ctgatgctgg tttctactgt gttggagttc tgcctagctg 420
tgctcactgc tgtgctgcag tggaaacaga ctgtctgact tccctggtta ctcatgtcct 480
caaagacgac tcatgatgct ggatatgaag aactattgac ttcttgggaa aaaacggaga 540
aatattaatt ggaaagttga tttttatgat aatatggaaa acctaaccat tataaaaaag 600
caaacttgag tttcctaaat gtaagcattt aaagtaatgc atatttgttt taaaaaatta 660
660
<210> 105
<211> 537
<212> DNA
<213> Homo sapiens
<400> 105
tggtgagcca gccaggagtg aagacgacag gtttgctgtc tcctttgcct gtgggtctgg 60
ggccccagcc tgggggagac ccgtgactcc aggcatgcta tcaggacaac ttcaacccga 120
ggggagatca gctctcccgc aacctggtgc cgctctctga cagcacaaca gaacctaagg 180
ggctacagga tgattcaagg aacagtgtgc tacaggacct cgcaagaaga ccctcaccag 240
atgcagcccc tctatgttgg acttcccagc ctccggaagt tagaaatgtg ctacaaccac 300
tcaaggtctg caaacagatt cctatttaga tgttgttgag agctgaattt ctggaacaag 360
agatatagat taagactgtt gttacatgtt gcctacatga ctttcaaaag cttgattccc 420
agtggcgctc tcaacagcag tcataaacaa tggtaattca atgtatattt atattcaact 480
gatatattaa ttggaatata ttaaaaatac gtatatttat attcagaata aaaaaaa 537
Claims (13)
- 서열번호 1 내지 105로 구성된 군에서 선택되는 어느 하나 이상의 염기서열로 표시되는 유전자의 mRNA 또는 상기 유전자가 코딩하는 단백질 발현 수준을 측정할 수 있는 제제를 포함하는 교모세포종의 진단 또는 예후 예측용 조성물.
- 제1항에 있어서, 상기 유전자 mRNA의 발현 수준을 측정하는 제제는 서열번호 1 내지 105로 구성된 군에서 선택되는 어느 하나 이상의 염기서열로 표시되는 유전자를 증폭할 수 있는 프라이머인 것을 특징으로 하는 교모세포종의 진단 또는 예후 예측용 조성물.
- 제1항에 있어서, 상기 유전자 mRNA의 발현 수준을 측정하는 제제는 서열번호 1 내지 105로 구성된 군에서 선택되는 어느 하나 이상의 염기서열로 표시되는 유전자에 특이적으로 결합하는 프로브인 것을 특징으로 하는 교모세포종의 진단 또는 예후 예측용 조성물.
- 제1항에 있어서, 상기 단백질의 발현 수준을 측정하는 제제는 서열번호 1 내지 105로 구성된 군에서 선택되는 어느 하나 이상의 염기서열로 표시되는 유전자가 코딩하는 단백질에 특이적인 항체 또는 압타머인 것을 특징으로 하는 교모세포종의 진단 또는 예후 예측용 조성물.
- 제1항에 있어서, 상기 유전자는 MARCO, CD180, MMP8, CR1 또는 GPR18인 것을 특징으로 하는 교모세포종의 진단 또는 예후 예측용 조성물.
- 제1항에 있어서, 상기 교모세포종은 중간엽 서브타입인 것을 특징으로 하는 교모세포종의 진단 또는 예후 예측용 조성물.
- 제1항 내지 제6항 중 어느 한 항의 조성물을 포함하는 교모세포종의 진단 또는 예후 예측용 키트.
- 제7항에 있어서, 상기 키트는 RT-PCR 키트, DNA 칩 키트 또는 단백질 칩 키트인 것을 특징으로 하는 교모세포종의 진단 또는 예후 예측용 키트.
- 다음 단계를 포함하는 교모세포종의 진단 또는 예후의 예측을 위한 정보제공 방법:
(a) 환자의 시료로부터 서열번호 1 내지 105로 구성된 군에서 선택되는 어느 하나 이상의 염기서열로 표시되는 유전자의 발현 수준 또는 상기 유전자가 코딩하는 단백질 발현 수준을 측정하는 단계; 및
(b) 상기 측정된 유전자의 발현 수준 또는 상기 유전자가 코딩하는 단백질의 발현 수준을 대조군 시료와 비교하는 단계.
- 제9항에 있어서, 상기 (b) 단계는 대조군에 비해 서열번호 1 내지 105로 구성된 군에서 선택되는 어느 하나 이상의 염기서열로 표시되는 유전자의 발현 수준 또는 상기 유전자가 코딩하는 단백질의 발현 수준이 증가하는 경우, 교모세포종으로 확인 또는 재발로 확인하는 것을 특징으로 하는 교모세포종의 진단 또는 예후의 예측을 위한 정보제공 방법.
- 제9항에 있어서, 상기 유전자는 MARCO, CD180, MMP8, CR1 또는 GPR18인 것을 특징으로 하는 교모세포종의 진단 또는 예후의 예측을 위한 정보제공 방법.
- 제9항에 있어서, 상기 시료는 조직 또는 세포로부터 분리된 종양 관련 대식세포인 것을 특징으로 하는 교모세포종의 진단 또는 예후의 예측을 위한 정보제공 방법.
- 제9항에 있어서, 상기 교모세포종은 중간엽 서브타입인 것을 특징으로 하는 교모세포종의 진단 또는 예후의 예측을 위한 정보제공 방법.
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KR20210090863A (ko) * | 2020-01-13 | 2021-07-21 | 주식회사 메타큐라 | 교모종줄기세포 엑소좀 유래 펩타이드를 포함하는 교모세포종의 진단용 바이오마커 조성물 |
CN113481298A (zh) * | 2021-06-18 | 2021-10-08 | 广东中科清紫医疗科技有限公司 | 免疫相关基因在预测弥漫性胶质瘤预后的试剂盒和系统中的应用 |
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CN114703283A (zh) * | 2022-04-07 | 2022-07-05 | 海南源轩生物科技有限公司 | Mns16a基因型作为生物标志在预测癌症化疗敏感性中的应用 |
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KR20210090863A (ko) * | 2020-01-13 | 2021-07-21 | 주식회사 메타큐라 | 교모종줄기세포 엑소좀 유래 펩타이드를 포함하는 교모세포종의 진단용 바이오마커 조성물 |
KR20210146495A (ko) * | 2020-05-26 | 2021-12-06 | 가톨릭대학교 산학협력단 | Lsp1 결핍 t 세포 |
CN113481298A (zh) * | 2021-06-18 | 2021-10-08 | 广东中科清紫医疗科技有限公司 | 免疫相关基因在预测弥漫性胶质瘤预后的试剂盒和系统中的应用 |
CN114703283A (zh) * | 2022-04-07 | 2022-07-05 | 海南源轩生物科技有限公司 | Mns16a基因型作为生物标志在预测癌症化疗敏感性中的应用 |
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