KR20180095096A - 알츠하이머병, 헌팅톤병, 자폐증 또는 기타 장애의 치료 방법 - Google Patents

알츠하이머병, 헌팅톤병, 자폐증 또는 기타 장애의 치료 방법 Download PDF

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KR20180095096A
KR20180095096A KR1020187022910A KR20187022910A KR20180095096A KR 20180095096 A KR20180095096 A KR 20180095096A KR 1020187022910 A KR1020187022910 A KR 1020187022910A KR 20187022910 A KR20187022910 A KR 20187022910A KR 20180095096 A KR20180095096 A KR 20180095096A
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alkyl
phenyl
alkenyl
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요셉 모스칼
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노오쓰웨스턴 유니버시티
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07Tetrapeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/00Drugs for disorders of the nervous system
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    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
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    • A61P25/00Drugs for disorders of the nervous system
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • AHUMAN NECESSITIES
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
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    • AHUMAN NECESSITIES
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
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    • A61P27/02Ophthalmic agents
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    • A61P27/02Ophthalmic agents
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
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    • AHUMAN NECESSITIES
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  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020187022910A 2011-04-27 2012-04-27 알츠하이머병, 헌팅톤병, 자폐증 또는 기타 장애의 치료 방법 Ceased KR20180095096A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161479593P 2011-04-27 2011-04-27
US61/479,593 2011-04-27
US201161527744P 2011-08-26 2011-08-26
US61/527,744 2011-08-26
PCT/US2012/035547 WO2012149389A2 (en) 2011-04-27 2012-04-27 Methods of treating alzheimer's disease, huntington's disease, autism, or other disorders

Related Parent Applications (1)

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KR1020137031028A Division KR20140043078A (ko) 2011-04-27 2012-04-27 알츠하이머병, 헌팅톤병, 자폐증 또는 기타 장애의 치료 방법

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Publication Number Publication Date
KR20180095096A true KR20180095096A (ko) 2018-08-24

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KR1020187022910A Ceased KR20180095096A (ko) 2011-04-27 2012-04-27 알츠하이머병, 헌팅톤병, 자폐증 또는 기타 장애의 치료 방법
KR1020207011211A Ceased KR20200043534A (ko) 2011-04-27 2012-04-27 알츠하이머병, 헌팅톤병, 자폐증 또는 기타 장애의 치료 방법
KR1020217011613A Ceased KR20210046843A (ko) 2011-04-27 2012-04-27 알츠하이머병, 헌팅톤병, 자폐증 또는 기타 장애의 치료 방법
KR1020137031028A Ceased KR20140043078A (ko) 2011-04-27 2012-04-27 알츠하이머병, 헌팅톤병, 자폐증 또는 기타 장애의 치료 방법
KR1020197008907A Ceased KR20190037359A (ko) 2011-04-27 2012-04-27 알츠하이머병, 헌팅톤병, 자폐증 또는 기타 장애의 치료 방법

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KR1020207011211A Ceased KR20200043534A (ko) 2011-04-27 2012-04-27 알츠하이머병, 헌팅톤병, 자폐증 또는 기타 장애의 치료 방법
KR1020217011613A Ceased KR20210046843A (ko) 2011-04-27 2012-04-27 알츠하이머병, 헌팅톤병, 자폐증 또는 기타 장애의 치료 방법
KR1020137031028A Ceased KR20140043078A (ko) 2011-04-27 2012-04-27 알츠하이머병, 헌팅톤병, 자폐증 또는 기타 장애의 치료 방법
KR1020197008907A Ceased KR20190037359A (ko) 2011-04-27 2012-04-27 알츠하이머병, 헌팅톤병, 자폐증 또는 기타 장애의 치료 방법

Country Status (13)

Country Link
US (4) US20140107037A1 (OSRAM)
EP (2) EP2701721A4 (OSRAM)
JP (1) JP6035326B2 (OSRAM)
KR (5) KR20180095096A (OSRAM)
CN (2) CN103974712A (OSRAM)
AU (1) AU2012249397B2 (OSRAM)
BR (1) BR112013027554A2 (OSRAM)
CA (1) CA2834286A1 (OSRAM)
EA (2) EA201790653A1 (OSRAM)
HK (1) HK1258231A1 (OSRAM)
MX (1) MX357761B (OSRAM)
SG (2) SG10202010665YA (OSRAM)
WO (1) WO2012149389A2 (OSRAM)

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KR101769999B1 (ko) 2008-09-18 2017-08-21 노오쓰웨스턴 유니버시티 Nmda 수용체 조절제 및 그의 용도
CN102933226A (zh) 2010-02-11 2013-02-13 西北大学 二级结构稳定化的nmda受体调节剂及其用途
KR101692275B1 (ko) 2010-02-11 2017-01-04 노오쓰웨스턴 유니버시티 2차 구조 안정화된 nmda 수용체 조절제 및 그의 용도
SI2951183T1 (sl) 2013-01-29 2019-07-31 Aptinyx Inc. Spiro-laktam NMDA receptorski modulatorji in njihove uporabe
WO2014120784A1 (en) 2013-01-29 2014-08-07 Naurex, Inc. Spiro-lactam nmda receptor modulators and uses thereof
CN105308049A (zh) 2013-01-29 2016-02-03 阿普廷伊克斯股份有限公司 螺-内酰胺nmda受体调节剂及其用途
WO2014120786A1 (en) 2013-01-29 2014-08-07 Naurex, Inc. Spiro-lactam nmda receptor modulators and uses thereof
US9738650B2 (en) 2013-01-29 2017-08-22 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
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CN105327349A (zh) * 2014-06-18 2016-02-17 上海翰森生物医药科技有限公司 Nmda受体拮抗剂的医药用途及其药物组合物
EP3157943A4 (en) * 2014-06-23 2018-01-24 Northwestern University Methods of treating or ameliorating migraine
CA3002070A1 (en) * 2015-10-16 2017-04-20 Northwestern University Pharmaceutical combination of an atypical antipsychotic and an nmda modulator for the treatment of schizophrenia,bipolar disorder, cognitive impairment and major depressive disorder
WO2017201283A1 (en) 2016-05-19 2017-11-23 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
WO2017201285A1 (en) 2016-05-19 2017-11-23 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
AU2017306158B2 (en) 2016-08-01 2021-10-14 Aptinyx Inc. Spiro-lactam and bis-spiro-lactam NMDA receptor modulators and uses thereof
WO2018026763A1 (en) 2016-08-01 2018-02-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
SG11201900554YA (en) 2016-08-01 2019-02-27 Aptinyx Inc Spiro-lactam nmda modulators and methods of using same
MX383650B (es) 2016-08-01 2025-03-14 Aptinyx Inc Moduladores del receptor nmda espiro-lactam y uso de los mismos.
JP7032378B2 (ja) 2016-08-01 2022-03-08 アプティニックス インコーポレイテッド スピロ-ラクタムnmda受容体修飾因子及びその使用
CN112204031B (zh) 2018-01-31 2024-05-24 元羿生物科技(香港)有限公司 螺-内酰胺nmda受体调节剂及其用途
US12012413B2 (en) 2019-11-11 2024-06-18 Tenacia Biotechnology (Hong Kong) Co., Limited Methods of treating painful diabetic peripheral neuropathy
KR102415692B1 (ko) 2020-09-01 2022-07-05 건국대학교 글로컬산학협력단 시냅스 불균형 조절에 의한 발달장애 예방, 개선 또는 치료용 조성물

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CA2716375C (en) * 2008-02-20 2018-05-29 The Children's Hospital Of Philadelphia Genetic alterations associated with autism and the autistic phenotype and methods of use thereof for the diagnosis and treatmemt of autism
KR101769999B1 (ko) * 2008-09-18 2017-08-21 노오쓰웨스턴 유니버시티 Nmda 수용체 조절제 및 그의 용도
PL2985032T3 (pl) * 2009-10-05 2019-07-31 Northwestern University Glyx do stosowania do leczenia choroby alzheimera, choroby parkinsona lub choroby huntingtona

Also Published As

Publication number Publication date
US20140107037A1 (en) 2014-04-17
WO2012149389A2 (en) 2012-11-01
HK1258231A1 (zh) 2019-11-08
KR20190037359A (ko) 2019-04-05
US20190209642A1 (en) 2019-07-11
EA201391581A1 (ru) 2014-05-30
EA201790653A1 (ru) 2017-07-31
EP3679931A2 (en) 2020-07-15
KR20210046843A (ko) 2021-04-28
KR20140043078A (ko) 2014-04-08
AU2012249397B2 (en) 2017-03-30
WO2012149389A3 (en) 2014-05-08
MX357761B (es) 2018-07-23
SG10202010665YA (en) 2020-11-27
AU2012249397A1 (en) 2013-11-07
EA029999B1 (ru) 2018-06-29
MX2013012526A (es) 2014-04-16
EP3679931A3 (en) 2020-10-14
BR112013027554A2 (pt) 2016-09-06
CN108283712A (zh) 2018-07-17
CA2834286A1 (en) 2012-11-01
US20210169964A1 (en) 2021-06-10
US20170049845A1 (en) 2017-02-23
KR20200043534A (ko) 2020-04-27
SG194230A1 (en) 2013-12-30
JP6035326B2 (ja) 2016-11-30
CN103974712A (zh) 2014-08-06
JP2014520072A (ja) 2014-08-21
EP2701721A2 (en) 2014-03-05
EP2701721A4 (en) 2015-12-16

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