KR20180095070A - 오베티콜산의 다형성 결정질 형태들 - Google Patents
오베티콜산의 다형성 결정질 형태들 Download PDFInfo
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- KR20180095070A KR20180095070A KR1020187020850A KR20187020850A KR20180095070A KR 20180095070 A KR20180095070 A KR 20180095070A KR 1020187020850 A KR1020187020850 A KR 1020187020850A KR 20187020850 A KR20187020850 A KR 20187020850A KR 20180095070 A KR20180095070 A KR 20180095070A
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- acid
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- cholan
- hydroxy
- keto
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| US14/979,005 US9982008B2 (en) | 2012-06-19 | 2015-12-22 | Preparation and uses of obeticholic acid |
| US14/979,005 | 2015-12-22 | ||
| PCT/US2016/012651 WO2017111979A1 (en) | 2015-12-22 | 2016-01-08 | Polymorphic crystalline forms of obeticholic acid |
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| WO2018211413A1 (en) * | 2017-05-15 | 2018-11-22 | Dr. Reddy’S Laboratories Limited | Solid forms of obeticholic acid and process for preparation |
| CN109280071A (zh) * | 2017-07-19 | 2019-01-29 | 东莞东阳光药物研发有限公司 | 奥贝胆酸的晶型及其制备方法 |
| CN107383139A (zh) * | 2017-08-09 | 2017-11-24 | 杭州和泽医药科技有限公司 | 一种3α‑羟基‑7‑氧代‑5β‑胆烷酸新衍生物制备奥贝胆酸的方法 |
| CZ31099U1 (cs) * | 2017-09-05 | 2017-10-17 | Zentiva, K.S. | Krystalické formy (3a,5B,6a,7a)-6-ethyl-3,7- dihydroxycholan-24-ové kyseliny |
| CN109485687A (zh) * | 2017-09-12 | 2019-03-19 | 成都弘达药业有限公司 | 奥贝胆酸的晶型j及其制备方法 |
| WO2019106043A1 (en) | 2017-11-29 | 2019-06-06 | Hexal Ag | Pharmaceutical composition comprising obeticholic acid |
| GB201812382D0 (en) | 2018-07-30 | 2018-09-12 | Nzp Uk Ltd | Compounds |
| CN113264972B (zh) * | 2020-02-14 | 2024-07-12 | 四川科伦药物研究院有限公司 | 一种制备奥贝胆酸的方法 |
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| ES2822375T3 (es) * | 2012-06-19 | 2021-04-30 | Intercept Pharmaceuticals Inc | Preparación de la forma no cristalina del ácido obeticólico |
| CN106459136B (zh) * | 2014-09-28 | 2018-06-26 | 江苏盛迪医药有限公司 | 一种奥贝胆酸的制备方法 |
| TWI686400B (zh) * | 2014-11-19 | 2020-03-01 | 英商Ｎｚｐ英國有限公司 | 化合物（二） |
| MX375863B (es) * | 2014-11-19 | 2025-03-07 | Nzp Uk Ltd | Esteroides de 6-alquil-7-hidroxi-4-en-3-ona como intermedios para la produccion de moduladores esteroideos del receptor x farnesoide (fxr) |
| EA033603B1 (ru) * | 2014-11-19 | 2019-11-08 | Nzp Uk Ltd | 6-альфа-алкил-6,7-дионовые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr |
| CN107108688B (zh) * | 2014-11-19 | 2019-10-29 | Nzp英国有限公司 | 作为制备类固醇FXR调节剂的中间体的6α-烷基-3,7-二酮类固醇 |
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| EA201891491A1 (ru) | 2018-11-30 |
| BR112018012590A2 (pt) | 2018-12-04 |
| CN108495858A (zh) | 2018-09-04 |
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| AU2016375566A1 (en) | 2018-07-05 |
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| PH12018501318A1 (en) | 2019-02-18 |
| CO2018006701A2 (es) | 2018-07-10 |
| WO2017111979A1 (en) | 2017-06-29 |
| MX2018007776A (es) | 2018-08-09 |
| CA3009149A1 (en) | 2017-06-29 |
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| US20180305397A1 (en) | Preparation and Uses of Obeticholic Acid | |
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