KR20180087423A - 치료 세포 활성화 또는 제거를 위한 이중 제어 - Google Patents

치료 세포 활성화 또는 제거를 위한 이중 제어 Download PDF

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KR20180087423A
KR20180087423A KR1020187020145A KR20187020145A KR20180087423A KR 20180087423 A KR20180087423 A KR 20180087423A KR 1020187020145 A KR1020187020145 A KR 1020187020145A KR 20187020145 A KR20187020145 A KR 20187020145A KR 20180087423 A KR20180087423 A KR 20180087423A
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polypeptide
cell
ligand
chimeric
nucleic acid
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조셉 헨리 바일
마이린 타이 듀옹
매튜 로버트 콜린슨-폴츠
아아론 에드워드 포스터
데이빗 마이클 스펜서
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벨리쿰 파마슈티컬스, 인크.
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KR1020187020145A 2015-12-14 2016-12-13 치료 세포 활성화 또는 제거를 위한 이중 제어 Ceased KR20180087423A (ko)

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US201562267277P 2015-12-14 2015-12-14
US62/267,277 2015-12-14
PCT/US2016/066371 WO2017106185A2 (en) 2015-12-14 2016-12-13 Dual controls for therapeutic cell activation or elimination

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US (3) US20170166877A1 (enExample)
EP (1) EP3390434A2 (enExample)
JP (4) JP2019506143A (enExample)
KR (1) KR20180087423A (enExample)
CN (2) CN108779163A (enExample)
AU (1) AU2016370470B2 (enExample)
CA (1) CA3007473A1 (enExample)
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020022851A1 (ko) 2018-07-26 2020-01-30 주식회사 엘지화학 세퍼레이터 및 이를 포함하는 전기화학소자
WO2021231806A1 (en) * 2020-05-13 2021-11-18 Rapa Therapeutics, Llc Antigen presenting t cells, sensitized, manufactured t cells and methods of treatment using the same

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9950282B2 (en) 2012-03-15 2018-04-24 Flodesign Sonics, Inc. Electronic configuration and control for acoustic standing wave generation
US10322949B2 (en) 2012-03-15 2019-06-18 Flodesign Sonics, Inc. Transducer and reflector configurations for an acoustophoretic device
US9752113B2 (en) 2012-03-15 2017-09-05 Flodesign Sonics, Inc. Acoustic perfusion devices
US10967298B2 (en) 2012-03-15 2021-04-06 Flodesign Sonics, Inc. Driver and control for variable impedence load
US9745548B2 (en) 2012-03-15 2017-08-29 Flodesign Sonics, Inc. Acoustic perfusion devices
US9458450B2 (en) 2012-03-15 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
US10689609B2 (en) 2012-03-15 2020-06-23 Flodesign Sonics, Inc. Acoustic bioreactor processes
US10737953B2 (en) 2012-04-20 2020-08-11 Flodesign Sonics, Inc. Acoustophoretic method for use in bioreactors
US20150320799A1 (en) 2012-12-20 2015-11-12 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
US9745569B2 (en) 2013-09-13 2017-08-29 Flodesign Sonics, Inc. System for generating high concentration factors for low cell density suspensions
CA2935960C (en) 2014-01-08 2023-01-10 Bart Lipkens Acoustophoresis device with dual acoustophoretic chamber
US9744483B2 (en) 2014-07-02 2017-08-29 Flodesign Sonics, Inc. Large scale acoustic separation device
JP6868554B2 (ja) 2014-09-02 2021-05-12 ベリカム ファーマシューティカルズ, インコーポレイテッド MyD88およびCD40ポリペプチドによるキメラ抗原受容体の共刺激
CA2978171A1 (en) * 2015-03-10 2016-09-15 J.H. Frederik Falkenburg T-cell receptors directed against the preferentially expressed antigen of melanoma and uses thereof
US11021699B2 (en) 2015-04-29 2021-06-01 FioDesign Sonics, Inc. Separation using angled acoustic waves
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11459540B2 (en) 2015-07-28 2022-10-04 Flodesign Sonics, Inc. Expanded bed affinity selection
US11474085B2 (en) 2015-07-28 2022-10-18 Flodesign Sonics, Inc. Expanded bed affinity selection
CN108601731A (zh) 2015-12-16 2018-09-28 磨石肿瘤生物技术公司 新抗原的鉴别、制造及使用
US11325948B2 (en) 2016-03-19 2022-05-10 Exuma Biotech Corp. Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL
US11111505B2 (en) 2016-03-19 2021-09-07 Exuma Biotech, Corp. Methods and compositions for transducing lymphocytes and regulating the activity thereof
WO2019055946A1 (en) * 2017-09-18 2019-03-21 F1 Oncology, Inc. METHODS AND COMPOSITIONS FOR THE GENETIC MODIFICATION AND EXPANSION OF LYMPHOCYTES AND THE REGULATION OF THE ACTIVITY THEREOF
JP7282521B2 (ja) 2016-04-08 2023-05-29 パーデュー・リサーチ・ファウンデイション Car t細胞療法のための方法および組成物
US11085035B2 (en) 2016-05-03 2021-08-10 Flodesign Sonics, Inc. Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
CN110494543A (zh) 2016-10-19 2019-11-22 弗洛设计声能学公司 通过声学的亲和细胞提取
JP7206214B2 (ja) 2016-12-13 2023-01-17 シアトル チルドレンズ ホスピタル (ディービーエイ シアトル チルドレンズ リサーチ インスティテュート) インビトロ及びインビボで操作された細胞において発現された化学誘導シグナル伝達複合体の外因性薬物活性化の方法
EP3579870A4 (en) 2017-02-07 2020-12-30 Seattle Children's Hospital (DBA Seattle Children's Research Institute) PHOSPHOLIPID ETHER (PLE) T CAR-LYMPHOCYTE TUMOR (CTCT) TARGETING AGENTS
WO2018160622A1 (en) 2017-02-28 2018-09-07 Endocyte, Inc. Compositions and methods for car t cell therapy
US20210147507A1 (en) 2017-05-09 2021-05-20 Bellicum Pharmaceuticals, Inc. Methods to augment or alter signal transduction
JP2020530454A (ja) 2017-08-07 2020-10-22 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 安全な細胞治療薬を生成するためのプラットフォーム
EP4576103A3 (en) 2017-10-10 2025-08-27 Gritstone bio, Inc. Neoantigen identification using hotspots
EP3714275A4 (en) 2017-11-22 2021-10-27 Gritstone bio, Inc. REDUCTION OF JUNCTION EPITOPIC PRESENTATION FOR NEOANTIGENS
EP3720479A2 (en) 2017-12-08 2020-10-14 Bellicum Pharmaceuticals, Inc. Methods for enhancing and maintaining car-t cell efficacy
KR20220066413A (ko) 2017-12-14 2022-05-24 프로디자인 소닉스, 인크. 음향 트랜스듀서 구동기 및 제어기
EP3728189A1 (en) 2017-12-20 2020-10-28 Bellicum Pharmaceuticals, Inc. Multimeric piperidine derivatives
CA3083779A1 (en) 2017-12-22 2019-06-27 Fate Therapeutics, Inc. Enhanced immune effector cells and use thereof
AU2019209432A1 (en) 2018-01-22 2020-08-06 Seattle Children's Hospital (dba Seattle Children's Research Institute) Methods of use for CAR T cells
CN111936518A (zh) 2018-02-06 2020-11-13 西雅图儿童医院(Dba西雅图儿童研究所) 对fl-ple标记的肿瘤表现出最佳的t细胞功能的荧光素特异性car
WO2019165237A1 (en) 2018-02-23 2019-08-29 Endocyte, Inc. Sequencing method for car t cell therapy
JP7480064B2 (ja) 2018-02-27 2024-05-09 グリットストーン バイオ インコーポレイテッド パンアレルモデルによる新生抗原の特定方法
CN111954715A (zh) 2018-03-29 2020-11-17 菲特治疗公司 工程改造的免疫效应细胞和其用途
CA3091490A1 (en) * 2018-04-27 2019-10-31 Seattle Children's Hospital (dba Seattle Children's Research Institute) Rapamycin resistant cells
US12448426B2 (en) 2018-05-17 2025-10-21 St. Jude Children's Research Hospital, Inc. Chimeric antigen receptors with MYD88 and CD40 costimulatory domains
KR20210099601A (ko) 2018-12-02 2021-08-12 페이트 세러퓨틱스, 인코포레이티드 향상된 iPSC 유래 효과기 세포를 사용한 면역요법
CN113423822A (zh) * 2018-12-13 2021-09-21 贝里坤制药股份有限公司 Psca car-t细胞
EP3920888A4 (en) * 2019-02-04 2023-11-01 Oisin Biotechnologies, Inc. FUSOGENIC LIPID NANOPARTICLES FOR TARGET CELL-SPECIFIC PRODUCTION OF RAPAMYCIN-INDUCIBLE THERAPEUTIC PROTEINS
WO2020219504A1 (en) * 2019-04-23 2020-10-29 The Regents Of The University Of California Modulating survival of therapeutic cells and methods, cells and nucleic acids related thereto
CN110079504A (zh) * 2019-05-06 2019-08-02 山东大学第二医院 一种含有不稳定结构域的car-t细胞及其制备方法和调节car-t细胞功能方法
CN114423498A (zh) * 2019-08-12 2022-04-29 贝里坤制药股份有限公司 免疫细胞的改进制剂
CN110592014A (zh) * 2019-08-14 2019-12-20 广东美赛尔细胞生物科技有限公司 一种在nk细胞治疗中免辐照体外体内持续去除饲养细胞的方法
CN112430578A (zh) * 2019-08-26 2021-03-02 深圳宾德生物技术有限公司 携带安全开关并靶向Her2的嵌合抗原受体T细胞及其制备方法和应用
US20220306715A1 (en) * 2019-08-30 2022-09-29 Shattuck Labs, Inc. Chimeric proteins in autoimmunity
US20230104317A1 (en) * 2020-01-31 2023-04-06 The Board Of Trustees Of The Leland Stanford Junior University Systems and Methods to Identify Genetic Silencers and Applications Thereof
WO2021257574A1 (en) * 2020-06-15 2021-12-23 Kiromic Biopharma Inc. Tri-switch technology for multi-dimensional control of cell therapy
US12275955B2 (en) 2020-06-19 2025-04-15 Fate Therapeutics, Inc. Combining iPSC derived effector cell types for immunotherapy use
CN112575035B (zh) * 2020-12-09 2022-11-29 贵州医科大学 一种诱导细胞凋亡的载体系统
AU2023249802A1 (en) 2022-04-08 2024-10-24 Fate Therapeutics, Inc. Cells having solid tumor targeting backbone and use thereof
CN118871471A (zh) 2022-04-08 2024-10-29 菲特治疗公司 用于肿瘤靶向的嵌合抗原受体
CN119654336A (zh) * 2022-05-16 2025-03-18 儿童医疗中心有限公司 治疗心脏病的组合物和方法
EP4634216A1 (en) 2022-12-16 2025-10-22 Repertoire Immune Medicines, Inc. T cell receptors binding hpv-16 epitopes
WO2025054345A1 (en) * 2023-09-05 2025-03-13 Remedium Bio, Inc. Genetic elements for adjustment of expression

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6187757B1 (en) * 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
AU755784B2 (en) * 1998-01-15 2002-12-19 Ariad Pharmaceuticals, Inc. Regulation of biological events using multimeric chimeric proteins
KR20150131218A (ko) * 2013-03-14 2015-11-24 벨리쿰 파마슈티컬스, 인크. T 세포 증식의 제어 방법
CA2912172A1 (en) * 2013-06-05 2014-12-11 Bellicum Pharmaceuticals, Inc. Methods for inducing partial apoptosis using caspase polypeptides
EP3925618A1 (en) * 2013-07-29 2021-12-22 2seventy bio, Inc. Multipartite signaling proteins and uses thereof
CN106132423B (zh) * 2014-02-14 2020-07-31 贝里坤制药股份有限公司 用诱导型嵌合多肽活化t细胞的方法
GB201503133D0 (en) * 2015-02-24 2015-04-08 Ucl Business Plc And Syncona Partners Llp Chimeric protein

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020022851A1 (ko) 2018-07-26 2020-01-30 주식회사 엘지화학 세퍼레이터 및 이를 포함하는 전기화학소자
EP4601102A2 (en) 2018-07-26 2025-08-13 LG Energy Solution, Ltd. Separator and electrochemical device comprising same
WO2021231806A1 (en) * 2020-05-13 2021-11-18 Rapa Therapeutics, Llc Antigen presenting t cells, sensitized, manufactured t cells and methods of treatment using the same

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