KR20180069788A - Pi3k 저해제 및 hdac 저해제를 포함하는 조성물 - Google Patents

Pi3k 저해제 및 hdac 저해제를 포함하는 조성물 Download PDF

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KR20180069788A
KR20180069788A KR1020187007811A KR20187007811A KR20180069788A KR 20180069788 A KR20180069788 A KR 20180069788A KR 1020187007811 A KR1020187007811 A KR 1020187007811A KR 20187007811 A KR20187007811 A KR 20187007811A KR 20180069788 A KR20180069788 A KR 20180069788A
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formula
mmol
methyl
alkyl
composition
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스티븐 조셉 셔틀워스
앤드류 데이비드 웨일
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카루스 떼라퓨틱스 리미티드
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020187007811A 2015-08-19 2016-08-19 Pi3k 저해제 및 hdac 저해제를 포함하는 조성물 Withdrawn KR20180069788A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1514756.4 2015-08-19
GBGB1514756.4A GB201514756D0 (en) 2015-08-19 2015-08-19 Compound and method of use
PCT/GB2016/052571 WO2017029514A1 (en) 2015-08-19 2016-08-19 Compositions comprising a pi3k inhibitor and an hdac inhibitor

Publications (1)

Publication Number Publication Date
KR20180069788A true KR20180069788A (ko) 2018-06-25

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KR1020187007811A Withdrawn KR20180069788A (ko) 2015-08-19 2016-08-19 Pi3k 저해제 및 hdac 저해제를 포함하는 조성물

Country Status (14)

Country Link
US (1) US20180243317A1 (cg-RX-API-DMAC7.html)
EP (2) EP3456355A1 (cg-RX-API-DMAC7.html)
JP (1) JP2018528192A (cg-RX-API-DMAC7.html)
KR (1) KR20180069788A (cg-RX-API-DMAC7.html)
CN (1) CN108348523A (cg-RX-API-DMAC7.html)
AU (1) AU2016307882A1 (cg-RX-API-DMAC7.html)
BR (1) BR112018003026A2 (cg-RX-API-DMAC7.html)
CA (1) CA2995991A1 (cg-RX-API-DMAC7.html)
GB (1) GB201514756D0 (cg-RX-API-DMAC7.html)
HK (1) HK1251466A1 (cg-RX-API-DMAC7.html)
IL (1) IL257521A (cg-RX-API-DMAC7.html)
MX (1) MX2018001990A (cg-RX-API-DMAC7.html)
SG (1) SG10201913619XA (cg-RX-API-DMAC7.html)
WO (1) WO2017029514A1 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200032519A (ko) * 2018-09-18 2020-03-26 인제대학교 산학협력단 프라시노스타트를 포함하는 염증성 장질환 치료용 약학 조성물

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2467387B1 (en) 2009-08-20 2015-01-07 Karus Therapeutics Limited Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors.
GB201204125D0 (en) 2012-03-08 2012-04-25 Karus Therapeutics Ltd Compounds
PT2994465T (pt) 2013-05-10 2018-10-25 Karus Therapeutics Ltd Novos inibidores de histona desacetilase
GB201402431D0 (en) 2014-02-12 2014-03-26 Karus Therapeutics Ltd Compounds
GB201514760D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds and method of use
GB201514758D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Formulation
GB201514751D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds
GB201514754D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
WO2018165520A1 (en) 2017-03-10 2018-09-13 Vps-3, Inc. Metalloenzyme inhibitor compounds
CA3125731A1 (en) 2018-01-12 2019-07-18 KDAc Therapeutics, Inc. Combination of a selective histone deacetylase 3 (hdac3) inhibitor and an immunotherapy agent for the treatment of cancer
US11952362B2 (en) 2018-07-23 2024-04-09 The Regents Of The University Of California Compositions and methods for treating epigenetic disease
GB201909468D0 (en) * 2019-07-01 2019-08-14 Karus Therapeutics Ltd Compounds for treating cancer
GB201913121D0 (en) * 2019-09-11 2019-10-23 Seald As Compositions and methods for treatment of cholangiocarcinoma
WO2021113401A2 (en) * 2019-12-02 2021-06-10 The Regents Of The University Of Colorado, A Body Corporate Histone deacytlase 6 modulation of titin protein mediated cardiac tissue stiffness and method for same
US20230038929A1 (en) 2019-12-05 2023-02-09 Verge Analytics, Inc. Fused Tricyclic Heterocyclic Compounds and Uses Thereof
WO2021127643A1 (en) 2019-12-20 2021-06-24 Tenaya Therapeutics, Inc. Fluoroalkyl-oxadiazoles and uses thereof
CN111686097A (zh) * 2020-07-31 2020-09-22 上海交通大学医学院附属第九人民医院 Lmk235在抑制瘢痕形成的药物中的应用
WO2022169882A1 (en) 2021-02-03 2022-08-11 Verge Analytics, Inc. Methods and treatment of viral infection caused by sars-cov-2
KR20240016950A (ko) 2021-05-04 2024-02-06 테나야 테라퓨틱스, 인코포레이티드 대사 질환 및 hfpef의 치료에 사용하기 위한 2-플루오로알킬-1,3,4-옥사디아졸-5-일-티아졸, hdac6 억제제
CN114890989B (zh) * 2022-05-25 2024-03-22 广东晨康生物科技有限公司 一种含氮衍生物为Linker的HDAC8降解剂其制备方法和应用
AU2024231699A1 (en) * 2023-03-03 2025-09-11 Ionctura Sa Combination of roginolisib and hdac inhibitor in the treatment of haematological malignancy
CN116987073B (zh) * 2023-08-03 2025-12-30 嘉兴大学 一种PI3Kα/HDAC6亚型选择性双重抑制剂及其应用
CN118750492A (zh) * 2024-07-15 2024-10-11 中日友好医院(中日友好临床医学研究所) 一种hdac6高选择抑制剂cay10603的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6905669B2 (en) 2001-04-24 2005-06-14 Supergen, Inc. Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
AU2007334343A1 (en) * 2006-12-15 2008-06-26 Ordway Research Institute, Inc. Treatments of therapy-resistant diseases comprising drug combinations
EP2467387B1 (en) 2009-08-20 2015-01-07 Karus Therapeutics Limited Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors.
PT2994465T (pt) 2013-05-10 2018-10-25 Karus Therapeutics Ltd Novos inibidores de histona desacetilase
JP6626437B2 (ja) * 2013-10-08 2019-12-25 アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． ヒストンデアセチラーゼ阻害剤とＨｅｒ２阻害剤またはＰＩ３Ｋ阻害剤のいずれかの組み合わせ
JP6584391B2 (ja) 2013-10-10 2019-10-02 アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 非ホジキンリンパ腫を治療するための、ｈｄａｃ阻害剤単独またはｐｉ３ｋ阻害剤との組み合わせ
GB201402431D0 (en) * 2014-02-12 2014-03-26 Karus Therapeutics Ltd Compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200032519A (ko) * 2018-09-18 2020-03-26 인제대학교 산학협력단 프라시노스타트를 포함하는 염증성 장질환 치료용 약학 조성물

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