KR20180044538A - Facial mask - Google Patents
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9722—Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
Description
본 발명은 피부 관리 분야 특히, 페이셜 마스크 분야에 관한 것이다.The present invention relates to the field of skin care, and more particularly to the field of facial masks.
얼굴은 다른 신체부위와 비교할 때 주위 환경에 노출되기 더 쉽고, 더 자주 바람, 일광 화상 (sunburn), 전자기 복사, 먼지 등에 의한 영향을 받는다. 사람들의 다양한 피부 특성 때문에, 얼굴의 몇몇 문제가 발생할 수 있고, 얼굴에 문제가 발생한 사람들은 아마 창피해 하거나, 불편함을 느낄 것이다. 더욱 심각하게는 이러한 문제들이 사람들의 직업과 결혼 등에 부정적인 영향을 끼칠 수 있다는 것이다.Faces are more susceptible to exposure to the environment when compared to other parts of the body, and are more often affected by wind, sunburn, electromagnetic radiation, dust, and the like. Due to the diverse skin characteristics of people, some problems of the face can occur, and people with facial problems may feel embarrassed or uncomfortable. More seriously, these problems can have a negative impact on people's jobs and marriage.
페이셜 마스크는 얼굴의 문제를 완화시키거나 제거하는데 매우 보편적으로 사용된다. 그러나, 대부분의 페이셜 마스크는 중금속 또는 인 (phosphor) 파우더 조성물을 포함하고 있으며, 이러한 페이셜 마스크를 오랜 기간 사용하면 사람 피부에 손상을 줄 수 있다.Facial masks are very commonly used to alleviate or eliminate facial problems. However, most facial masks contain heavy metal or phosphor powder compositions, and such facial masks can damage human skin for long periods of time.
그러므로, 피부의 손상을 줄이기 위해 오랜 기간 사용하는데 알맞은 자연적이고 안전한 구성을 포함하는 페이셜 마스크를 개발하는 것이 필요하다.Therefore, it is necessary to develop a facial mask that includes a natural and safe configuration suitable for long-term use to reduce skin damage.
본 발명의 목적은 안전하고 효과적인 페이셜 마스크를 제공하는 것이다.It is an object of the present invention to provide a safe and effective facial mask.
본 발명의 일 측면에 따르면, 본 발명에서 제공된 페이셜 마스크는 안젤리카 (angelica) 8 내지 13 중량부, 큰꽃삽주 (white atractylodes rhizome) 8 내지 16 중량부, 백급 파우더 (Bletilla hyacinthina Reichb powder) 8 내지 15 중량부, 몽고황기 (astragalus mongholicus) 9 내지 16 중량부, 천궁 (Ligusticum wallichii) 5 내지 15 중량부, 스피룰리나 (spirulina) 3 내지 7 중량부, 이인 (coix seed) 10 내지 20 중량부 및 청보리 (Barley Green) 5 내지 9 중량부를 포함한다.According to one aspect of the present invention, the facial mask provided in the present invention comprises 8 to 13 parts by weight of angelica, 8 to 16 parts by weight of white atractylodes rhizome, 8 to 15 parts by weight of Bletilla hyacinthina Reichb powder, 9 to 16 parts by weight of astragalus mongholicus, 5 to 15 parts by weight of Ligusticum wallichii, 3 to 7 parts by weight of spirulina, 10 to 20 parts by weight of coix seed, Green) of 5 to 9 parts by weight.
본 발명의 이로운 효과는 전통적인 한약 원재료가 서로 상호작용하여 상승 효과를 가져와 안면 혈액 순환을 촉진시킬 수 있고, 안면의 노폐물과 독소를 제거하는 것이다.The beneficial effect of the present invention is that the traditional herbal ingredients interact with each other to produce a synergistic effect that promotes facial blood circulation and eliminates waste products and toxins on the face.
전통 한약을 포함하는 페이셜 마스크는 영양성분과 유효성분들 (nutritional and effective substances)이 피부의 깊은 층으로 침투할 수 있게 하며, 더 나아가 보습 (moisture retention), 피부를 촉촉하게 하고 (moistening), 피부의 미백 (whitening), 주근깨 제거, 주름 방지 (resistance), 노화 방지 (anti-aging), 소염, 독소 제거 및 여드름 방지 (anti-acne)에 중요한 역할을 한다.Facial masks containing traditional herbal medicine are designed to allow nutrient and effective substances to penetrate into the deep layers of the skin and further promote moisture retention, moistening the skin, It plays an important role in whitening, freckle removal, resistance, anti-aging, anti-inflammation, toxin removal and anti-acne.
더 나아가, 본 발명에서 제공되는 페이셜 마스크에 있는 다양한 성분들은 서로 상호작용하여 장시간 품질이 유지 (guarantee)되는 결과를 가져올 것이다.Furthermore, the various components in the facial mask provided in the present invention will interact with each other, resulting in a long-term quality guarantee.
마지막으로, 본 발명에서 제공되는 페이셜 마스크는 오직 천연 식물 성분을 포함할 뿐 어떠한 화학성분도 포함하지 않는다. 그러므로, 본 발명은 사람들의 피부를 건강하게 하고 손상을 거의 주지 않는다.Finally, the facial mask provided in the present invention contains only natural plant components and does not contain any chemical components. Therefore, the present invention makes the skin of people healthier and gives little damage.
이하의 실시예들 (examples)은 본 발명의 범위 내에 있는 실시예를 더욱 자세하게 (further) 묘사하고 보여준다. 이하의 예들은 본 발명을 설명하기 위한 목적일 뿐이고 본 발명의 범위를 제한하지 않으며, 본 발명의 다양한 변형은 본 발명의 범위 (spirit and scope)로부터 벗어나지 않을 것이다.The following examples further illustrate and illustrate embodiments within the scope of the present invention. The following examples are intended to illustrate the present invention and do not limit the scope of the present invention, and various modifications of the present invention will not depart from the spirit and scope of the present invention.
본 발명의 일 측면에 따르면, 본 발명에서 제공된 페이셜 마스크는 안젤리카 (angelica) 8 내지 13 중량부, 큰꽃삽주 (white atractylodes rhizome) 8 내지 16 중량부, 백급 파우더 (Bletilla hyacinthina Reichb powder) 8 내지 15 중량부, 몽고황기 (astragalus mongholicus) 9 내지 16 중량부, 천궁 (Ligusticum wallichii) 5 내지 15 중량부, 스피룰리나 (spirulina) 3 내지 7 중량부, 이인 (coix seed) 10 내지 20 중량부 및 청보리 (Barley Green) 5 내지 9 중량부를 포함한다.According to one aspect of the present invention, the facial mask provided in the present invention comprises 8 to 13 parts by weight of angelica, 8 to 16 parts by weight of white atractylodes rhizome, 8 to 15 parts by weight of Bletilla hyacinthina Reichb powder, 9 to 16 parts by weight of astragalus mongholicus, 5 to 15 parts by weight of Ligusticum wallichii, 3 to 7 parts by weight of spirulina, 10 to 20 parts by weight of coix seed, Green) of 5 to 9 parts by weight.
본 발명의 첫 번재 실시예에 따르면, 페이셜 마스크 조성물은 안젤리카 (angelica) 8 중량부, 큰꽃삽주 (white atractylodes rhizome) 8 중량부, 백급 파우더 (Bletilla hyacinthina Reichb powder) 8 중량부, 몽고황기 (astragalus mongholicus) 9 중량부, 천궁 (Ligusticum wallichii) 5 중량부, 스피룰리나 (spirulina) 3 중량부, 이인 (coix seed) 10 중량부 및 청보리 (Barley Green) 5 중량부를 포함한다.According to a first embodiment of the present invention, the facial mask composition comprises 8 parts by weight of angelica, 8 parts by weight of white atractylodes rhizome, 8 parts by weight of Bletilla hyacinthina Reichb powder, 9 parts by weight of mongholicus, 5 parts by weight of Ligusticum wallichii, 3 parts by weight of spirulina, 10 parts by weight of coix seed and 5 parts by weight of Barley Green.
본 발명의 두 번째 실시예에 따르면, 페이셜 마스크 조성물은 안젤리카 (angelica) 13 중량부, 큰꽃삽주 (white atractylodes rhizome) 16 중량부, 백급 파우더 (Bletilla hyacinthina Reichb powder) 15 중량부, 몽고황기 (astragalus mongholicus) 16 중량부, 천궁 (Ligusticum wallichii) 15 중량부, 스피룰리나 (spirulina) 7 중량부, 이인 (coix seed) 20 중량부 및 청보리 (Barley Green) 9 중량부를 포함한다.According to a second embodiment of the present invention, the facial mask composition comprises 13 parts by weight of angelica, 16 parts by weight of white atractylodes rhizome, 15 parts by weight of Bletilla hyacinthina Reichb powder, 16 parts by weight of mongholicus, 15 parts by weight of Ligusticum wallichii, 7 parts by weight of spirulina, 20 parts by weight of coix seed and 9 parts by weight of Barley Green.
본 발명의 세 번째 실시예에 따르면, 페이셜 마스크 조성물은 안젤리카 (angelica) 8 중량부, 큰꽃삽주 (white atractylodes rhizome) 16 중량부, 백급 파우더 (Bletilla hyacinthina Reichb powder) 8 중량부, 몽고황기 (astragalus mongholicus) 16 중량부, 천궁 (Ligusticum wallichii) 5 중량부, 스피룰리나 (spirulina) 7 중량부, 이인 (coix seed) 10 중량부 및 청보리 (Barley Green) 9 중량부를 포함한다.According to a third embodiment of the present invention, the facial mask composition comprises 8 parts by weight of angelica, 16 parts by weight of white atractylodes rhizome, 8 parts by weight of Bletilla hyacinthina Reichb powder, 16 parts by weight of mongholicus, 5 parts by weight of Ligusticum wallichii, 7 parts by weight of spirulina, 10 parts by weight of coix seed and 9 parts by weight of Barley Green.
본 발명의 네 번째 실시예에 따르면, 페이셜 마스크 조성물은 안젤리카 (angelica) 13 중량부, 큰꽃삽주 (white atractylodes rhizome) 8 중량부, 백급 파우더 (Bletilla hyacinthina Reichb powder) 15 중량부, 몽고황기 (astragalus mongholicus) 9 중량부, 천궁 (Ligusticum wallichii) 15 중량부, 스피룰리나 (spirulina) 3 중량부, 이인 (coix seed) 20 중량부 및 청보리 (Barley Green) 5 중량부를 포함한다.According to a fourth embodiment of the present invention, the facial mask composition comprises 13 parts by weight of angelica, 8 parts by weight of white atractylodes rhizome, 15 parts by weight of Bletilla hyacinthina Reichb powder, 9 parts by weight of mongholicus, 15 parts by weight of Ligusticum wallichii, 3 parts by weight of spirulina, 20 parts by weight of coix seed and 5 parts by weight of Barley Green.
본 발명의 다섯 번째 실시예에 따르면, 페이셜 마스크 조성물은 안젤리카 (angelica) 10.5 중량부, 큰꽃삽주 (white atractylodes rhizome) 12 중량부, 백급 파우더 (Bletilla hyacinthina Reichb powder) 11.5 중량부, 몽고황기 (astragalus mongholicus) 12.5 중량부, 천궁 (Ligusticum wallichii) 10 중량부, 스피룰리나 (spirulina) 5 중량부, 이인 (coix seed) 15 중량부 및 청보리 (Barley Green) 7 중량부를 포함한다.According to a fifth embodiment of the present invention, the facial mask composition comprises 10.5 parts by weight of angelica, 12 parts by weight of white atractylodes rhizome, 11.5 parts by weight of Bletilla hyacinthina Reichb powder, 12.5 parts by weight of mongholicus, 10 parts by weight of Ligusticum wallichii, 5 parts by weight of spirulina, 15 parts by weight of coix seed and 7 parts by weight of Barley Green.
본 발명의 여섯 번째 실시예에 따르면, 페이셜 마스크 조성물은 안젤리카 (angelica) 8 중량부, 큰꽃삽주 (white atractylodes rhizome) 12 중량부, 백급 파우더 (Bletilla hyacinthina Reichb powder) 8 중량부, 몽고황기 (astragalus mongholicus) 12.5 중량부, 천궁 (Ligusticum wallichii) 5 중량부, 스피룰리나 (spirulina) 5 중량부, 이인 (coix seed) 10 중량부 및 청보리 (Barley Green) 7 중량부를 포함한다.According to a sixth embodiment of the present invention, the facial mask composition comprises 8 parts by weight of angelica, 12 parts by weight of white atractylodes rhizome, 8 parts by weight of Bletilla hyacinthina Reichb powder, 12.5 parts by weight of mongholicus, 5 parts by weight of Ligusticum wallichii, 5 parts by weight of spirulina, 10 parts by weight of coix seed and 7 parts by weight of Barley Green.
본 발명의 일곱 번째 실시예에 따르면, 페이셜 마스크 조성물은 안젤리카 (angelica) 13 중량부, 큰꽃삽주 (white atractylodes rhizome) 12 중량부, 백급 파우더 (Bletilla hyacinthina Reichb powder) 15 중량부, 몽고황기 (astragalus mongholicus) 12.5 중량부, 천궁 (Ligusticum wallichii) 15 중량부, 스피룰리나 (spirulina) 5 중량부, 이인 (coix seed) 20 중량부 및 청보리 (Barley Green) 7 중량부를 포함한다.According to a seventh embodiment of the present invention, the facial mask composition comprises 13 parts by weight of angelica, 12 parts by weight of white atractylodes rhizome, 15 parts by weight of Bletilla hyacinthina Reichb powder, 12.5 parts by weight of mongholicus, 15 parts by weight of Ligusticum wallichii, 5 parts by weight of spirulina, 20 parts by weight of coix seed and 7 parts by weight of Barley Green.
본 발명의 여덟 번째 실시예에 따르면, 페이셜 마스크 조성물은 안젤리카 (angelica) 11.5 중량부, 큰꽃삽주 (white atractylodes rhizome) 8 중량부, 백급 파우더 (Bletilla hyacinthina Reichb powder) 12 중량부, 몽고황기 (astragalus mongholicus) 9 중량부, 천궁 (Ligusticum wallichii) 10 중량부, 스피룰리나 (spirulina) 3 중량부, 이인 (coix seed) 15 중량부 및 청보리 (Barley Green) 5 중량부를 포함한다.According to an eighth embodiment of the present invention, the facial mask composition comprises 11.5 parts by weight of angelica, 8 parts by weight of white atractylodes rhizome, 12 parts by weight of Bletilla hyacinthina Reichb powder, 9 parts by weight of mongholicus, 10 parts by weight of Ligusticum wallichii, 3 parts by weight of spirulina, 15 parts by weight of coix seed and 5 parts by weight of Barley Green.
본 발명의 아홉 번째 실시예에 따르면, 페이셜 마스크 조성물은 안젤리카 (angelica) 11.5 중량부, 큰꽃삽주 (white atractylodes rhizome) 16 중량부, 백급 파우더 (Bletilla hyacinthina Reichb powder) 11.5 중량부, 몽고황기 (astragalus mongholicus) 16 중량부, 천궁 (Ligusticum wallichii) 10 중량부, 스피룰리나 (spirulina) 7 중량부, 이인 (coix seed) 15 중량부 및 청보리 (Barley Green) 9 중량부를 포함한다.According to a ninth embodiment of the present invention, the facial mask composition comprises 11.5 parts by weight of angelica, 16 parts by weight of white atractylodes rhizome, 11.5 parts by weight of Bletilla hyacinthina Reichb powder, 16 parts by weight of mongholicus, 10 parts by weight of Ligusticum wallichii, 7 parts by weight of spirulina, 15 parts by weight of coix seed and 9 parts by weight of Barley Green.
본 발명의 열 번째 실시예에 따르면, 페이셜 마스크 조성물은 안젤리카 (angelica) 10 중량부, 큰꽃삽주 (white atractylodes rhizome) 9 중량부, 백급 파우더 (Bletilla hyacinthina Reichb powder) 9 중량부, 몽고황기 (astragalus mongholicus) 10 중량부, 천궁 (Ligusticum wallichii) 6 중량부, 스피룰리나 (spirulina) 4 중량부, 이인 (coix seed) 12 중량부 및 청보리 (Barley Green) 6 중량부를 포함한다.According to a tenth embodiment of the present invention, the facial mask composition comprises 10 parts by weight of angelica, 9 parts by weight of white atractylodes rhizome, 9 parts by weight of Bletilla hyacinthina Reichb powder, 10 parts by weight of mongholicus, 6 parts by weight of Ligusticum wallichii, 4 parts by weight of spirulina, 12 parts by weight of coix seed and 6 parts by weight of Barley Green.
본 발명의 열한 번째 실시예에 따르면, 페이셜 마스크 조성물은 안젤리카 (angelica) 12 중량부, 큰꽃삽주 (white atractylodes rhizome) 14 중량부, 백급 파우더 (Bletilla hyacinthina Reichb powder) 13 중량부, 몽고황기 (astragalus mongholicus) 13 중량부, 천궁 (Ligusticum wallichii) 12 중량부, 스피룰리나 (spirulina) 3 내지 7 중량부, 이인 (coix seed) 16 중량부 및 청보리 (Barley Green) 8 중량부를 포함한다.According to the eleventh embodiment of the present invention, the facial mask composition comprises 12 parts by weight of angelica, 14 parts by weight of white atractylodes rhizome, 13 parts by weight of Bletilla hyacinthina Reichb powder, 13 parts by weight of mongholicus, 12 parts by weight of Ligusticum wallichii, 3 to 7 parts by weight of spirulina, 16 parts by weight of coix seed and 8 parts by weight of Barley Green.
본 발명의 열두 번째 실시예에 따르면, 페이셜 마스크 조성물은 안젤리카 (angelica) 10 중량부, 큰꽃삽주 (white atractylodes rhizome) 11 중량부, 백급 파우더 (Bletilla hyacinthina Reichb powder) 12 중량부, 몽고황기 (astragalus mongholicus) 13 중량부, 천궁 (Ligusticum wallichii) 14 중량부, 스피룰리나 (spirulina) 6 중량부, 이인 (coix seed) 19 중량부 및 청보리 (Barley Green) 8 중량부를 포함한다.According to a twelfth embodiment of the present invention, the facial mask composition comprises 10 parts by weight of angelica, 11 parts by weight of white atractylodes rhizome, 12 parts by weight of Bletilla hyacinthina Reichb powder, 13 parts by weight of mongholicus, 14 parts by weight of Ligusticum wallichii, 6 parts by weight of spirulina, 19 parts by weight of coix seed and 8 parts by weight of Barley Green.
본 발명의 열세 번째 실시예에 따르면, 페이셜 마스크 조성물은 안젤리카 (angelica) 9 중량부, 큰꽃삽주 (white atractylodes rhizome) 9 중량부, 백급 파우더 (Bletilla hyacinthina Reichb powder) 14 중량부, 몽고황기 (astragalus mongholicus) 15 중량부, 천궁 (Ligusticum wallichii) 12 중량부, 스피룰리나 (spirulina) 4 중량부, 이인 (coix seed) 11 중량부 및 청보리 (Barley Green) 6 중량부를 포함한다.According to a thirteenth embodiment of the present invention, the facial mask composition comprises 9 parts by weight of angelica, 9 parts by weight of white atractylodes rhizome, 14 parts by weight of Bletilla hyacinthina Reichb powder, 15 parts by weight of mongholicus, 12 parts by weight of Ligusticum wallichii, 4 parts by weight of spirulina, 11 parts by weight of coix seed and 6 parts by weight of Barley Green.
용어 "중량부"는 각각의 구성 또는 재료 사이의 비율을 의미 (worth mentioning)하는 것으로 전체 중량에 대한 퍼센트를 의미하는 것은 아니다.The term " part by weight " is used to indicate a ratio between each constituent or material and is not meant to be a percentage of the total weight.
제조 방법Manufacturing method
위에서 언급된 재료 또는 성분은 시장에서 상업적으로 사용 가능한 것이나 통상의 가공방법에 의해 수득될 수 있고, 예컨대, 이러한 재료들은 말리고 분쇄하여 20 내지 30 mesh의 평균 입자 크기 범위를 가지는 파우더로 얻어질 수 있다.The above-mentioned materials or components can be obtained commercially or commercially by the usual processing methods, for example, these materials can be obtained as a powder having an average particle size range of 20 to 30 mesh by drying and pulverizing .
전통 한약 추출물의 제조는 이하의 과정을 포함한다.The preparation of traditional Chinese medicinal extracts includes the following procedures.
각각의 성분들을 교반하고 갈아서 파우더로 만들고, 용매로 에탄올을 사용하여 60℃에서 30MPa으로 0.5시간 동안 상기 파우더를 초임계 (supercritical) 이산화 탄소로 추출하였다. 특히, 에탄올의 양은 상기 파우더 g 당 2 ml이고, 바람직한 (analytical) 압력은 10MPa이고 바람직한 (analytical) 온도는 20 ℃이다.Each of the ingredients was stirred and ground to powder, and the powder was extracted with supercritical carbon dioxide at 60 DEG C and 30 MPa for 0.5 hour using ethanol as a solvent. In particular, the amount of ethanol is 2 ml per g of the powder, the preferred analytical pressure is 10 MPa and the analytical temperature is 20 < 0 > C.
감압 농도 (pressure concentration) 및 에탄올의 복구 (recovery of the ethanol)를 수행하여 에탄올 추출물의 농축 용액 (ethanol extract concentrate)을 얻었다.The pressure concentration and recovery of the ethanol were performed to obtain the ethanol extract concentrate of the ethanol extract.
초임계 이산화탄소로 추출한 후 잔여물 (the redisual)에 대해 두 번의 끓임 (boiling)이 수행되며, 여기서 첫 번째 끓임은 30 내지 50분 동안 물의 8 내지 10배(8-10 times of water)의 잔여물을 끓이는 것이고; 두 번째 끓임은 80 내지 90분 동안 물의 9 내지 12배(9-12 times of water)의 잔여물을 끓이는 것이다.After extraction with supercritical carbon dioxide, two boiling operations are carried out on the redisual, wherein the first boiling takes place between 8 and 10 times (8-10 times of water) of water for 30 to 50 minutes Boiling; The second boil boils the residue 9 to 12 times (9-12 times of water) of water for 80 to 90 minutes.
끓인 액체를 필터링 (filtering)하고, 필터링된 (filtered) 액체를 혼합한 다음, 50 ℃에서 1.3 내지 1.5 사이의 밀도로 액체를 농축한다.Filter the boiled liquid, mix the filtered liquid, and concentrate the liquid at a density between 1.3 and 1.5 at 50 ° C.
1.3 내지 1.5 사이의 밀도를 가진 액체를 건조하여 추출물을 얻었다.A liquid having a density between 1.3 and 1.5 was dried to obtain an extract.
다공성 흡착 수지로 추출물을 농축할 때, 특히, 추출물은 특정 양의 물로 희석되고, D-101 다공성 흡착 수지의 부피와 같은 부피로 섞이고 D-101 또는 AB-8 타입과 다른 비극성, 약한 극성 또는 중간 극성의 다공성 흡착 수지로 로딩된다. 로딩된 부피는 산물의 부피와 수지 간에 1:3의 비가 되게끔 한다 (calculated). 15분의 정적 (static) 흡착 후, 용출 (elution)은 다른 밀도를 가진 에탄올 부피의 10배를 수행되고 60% 내지 70%의 에탄올 용출 용액은 갈색 분말을 얻기 위해 모아진다.When concentrating the extract with a porous adsorbent resin, in particular the extract is diluted with a certain amount of water, mixed with a volume equal to the volume of the D-101 porous adsorbent resin and mixed with a non-polar, weak polarity or medium Polarity porous adsorbent resin. The loaded volume causes a 1: 3 ratio between the volume of the product and the resin (calculated). After 15 minutes of static adsorption, elution is carried out 10 times the volume of ethanol with different densities and 60 to 70% of the ethanol elution solution is collected to obtain a brown powder.
또한, 분말에 초임계 이산화탄소 추출을 통해 얻어진 갈색 오일 같은 점액을 섞고, 이를 통해 전통 한약 추출물을 얻었다.In addition, the powder was mixed with mucilage such as brown oil obtained through supercritical carbon dioxide extraction, thereby obtaining a traditional Chinese medicine extract.
UVB에 의해 유도되는 (induced) 색소 (pigmentation) 모델을 사용하고 전통 한약은 아래와 같이 투여된다.Using UVB-induced pigmentation model, traditional herbal medicine is administered as follows.
각 기니 피그 등에 있는 세 개의 분리된 영역 (2cm x 2cm)을 선택하고 각 기니 피그 등의 긴 털은 가위로 자르고 짧은 털은 전기면도기로 밀었다 (cleared off). 그 다음, 위 영역을 310 내지 315 nm 사이의 스펙트럼 피크를 가지는 UVB 광원을 구비한 광 치료 장치인 SS-04B로 조사하였다 (irradiated). 위 영역은 매일 20분 동안 200 mJ/cm2 의 양으로 조사되었고, 2800 mJ/cm2의 축적된 조사량을 얻기 위해 조사는 2주 동안 지속되었다. 위 한약 (The medicine)은 조사를 끝낸 후 2시간 투여되었고 위 한약 (The medicine)은 조사가 끝난 후 2주 동안 지속적으로 투여되었다. 그 다음, 병리학 검사를 위해 표면 조직을 수득하였다.Three separate areas (2 cm x 2 cm) in each guinea pig were selected and the long hairs of each guinea pig were cut with scissors and the short hairs were cleared off. The upper region was then irradiated with SS-04B, a light therapy device with a UVB light source having a spectral peak between 310 and 315 nm. The upper area was irradiated with an amount of 200 mJ / cm 2 for 20 minutes daily and the irradiation lasted for 2 weeks to obtain an accumulated dose of 2800 mJ / cm 2 . The medicine was administered for 2 hours after the investigation and the medicine was continuously administered for 2 weeks after the investigation. The surface tissues were then obtained for pathological examination.
위 샘플은 (The sample) 멜라닌과 DOPA 양성 세포를 포함하는 세포의 수를 관찰하기 위해 3개의 그룹으로 나누어졌다.The sample was divided into three groups to observe the number of cells containing melanin and DOPA-positive cells.
그룹 1: UVB에 의해 조사되지 않은 보통의 기니 피그 등의 피부를 포함하는 비교그룹 (reference group);Group 1: a reference group containing skin such as normal guinea pigs not irradiated by UVB;
그룹 2: UVB로 조사되었지만 본 발명의 전통 한약을 바르지 않은 (coated) 기니 피그 등의 피부를 포함하는 그룹;Group 2: a group comprising skin such as guinea pigs coated with UVB but coated with traditional herbal medicine of the present invention;
그룹 3: UVB 조사 후 실시예 1 내지 13의 전통 한약으로 코팅된 기니 피그 등의 피부를 포함하는 그룹으로, 여기서 각각의 전통 한약의 농도는 0.5 및 1 mg/ml이다.Group 3: group containing skin such as guinea pigs coated with the traditional herbal medicine of Examples 1 to 13 after UVB irradiation, wherein the concentration of each traditional herbal medicine is 0.5 and 1 mg / ml.
염색 과정Dyeing Process
1) HE 염색: 기니 피그 등의 피부 샘플 (2cm x 2cm)은 종래의 파라핀 절편 (paraffin section)으로 HE 염색되었다.1) HE staining: Skin samples (2 cm x 2 cm) of guinea pigs and the like were HE stained with a conventional paraffin section.
2) Schmorl 염색:2) Schmorl staining:
a. 단면을 물로 세정한다;a. The cross section is rinsed with water;
b. 단면을 40 ml의 FeCl3 용액과 0.04 mol/L의 농도를 가진 6 ml의 페리시안화 칼륨 용액 (potassium ferricyanide)과 0.04 mol/L의 농도를 가진 6 ml의 증류수의 혼합물로 10분 동안 처리한다;b. The cross section is treated with a mixture of 40 ml of FeCl 3 solution and 6 ml of potassium ferricyanide with a concentration of 0.04 mol / L and 6 ml of distilled water with a concentration of 0.04 mol / L for 10 minutes;
c. 그 다음 단면을 흐르는 물로 세정한다.c. The section is then rinsed with running water.
결과: 멜라닌 세포는 갈색, 검은 색 입자로 염색되었다.Results: Melanocytes were stained with brown and black particles.
3) Imokawa 염색3) Imokawa dyeing
a. 피부 샘플 (2cm x 2cm)을 기니 피그의 등에서 얻고, 0.1 mol/L (PH 6.8)의 농도를 가진 PBS 용액으로 세정한 다음 1 mol/L의 농도를 가진 브롬화 나트륨으로 37 ℃에서 5 시간 동안 배양한다.a. Skin samples (2 cm x 2 cm) were obtained from guinea pigs and the like, washed with a PBS solution having a concentration of 0.1 mol / L (pH 6.8) and then incubated with sodium bromide at a concentration of 1 mol / L for 5 hours do.
b. 피부의 표피 (cuticle) 및 진피 (dermis)를 분리한다.b. Separate cuticle and dermis of skin.
c. 표피는 3.33 mol/L (10%)의 농도를 가진 냉각된 중성 포르말린 용액으로 30분 동안 조정된 후, 그 다음 0.1 mol/L (pH 6.8)의 농도를 가진 PBS 용액으로 두 번 세정한다.c. The epidermis is conditioned for 30 minutes with a cold neutral formalin solution with a concentration of 3.33 mol / L (10%), then rinsed twice with PBS solution with a concentration of 0.1 mol / L (pH 6.8).
d. 그 다음 표피를 0.1 mol/L의 농도를 가진 PBS 용액으로 5시간 동안 염색한다.d. The epidermis is then stained with PBS solution with a concentration of 0.1 mol / L for 5 hours.
결과: 멜라닌 세포는 검은 색과 갈색 입자로 염색되었다.Results: Melanocytes were stained with black and brown particles.
광학 현미경 관찰Optical microscope observation
1) 멜라닌 입자 셀의 계산: Schmorl 염색 과정에서, 각 샘플의 표피 기질 (substrate)의 mm2 당 멜라닌 세포의 수는 고배율 렌즈를 통해 순 (Net) 접안 마이크로미터 단일 블라인드 방법으로 계산된다;1) Calculation of Melanin Particle Cells: In the Schmorl staining procedure, the number of melanocytes per mm 2 of the epidermal substrate of each sample is calculated by a Net eyepiece micrometer single blind method through a high magnification lens;
2) DOPA 양성 세포의 계산: Imokawa 염색 과정에서, 각 샘플의 표피 기질 (substrate)의 mm2 당 DOPA 양성 멜라닌 세포의 수는 고배율 렌즈를 통해 순 접안 마이크로미터 단일 블라인드 방법으로 계산된다.2) Calculation of DOPA-positive cells: In the Imokawa staining procedure, the number of DOPA-positive melanocytes per mm 2 of the epidermal substrate of each sample is calculated by a forward eyepiece micrometer single blind method through a high magnification lens.
표 1은 조사되지 않은 그룹, 조사된 그룹 및 본 발명의 실시예 1 내지 13에 따른 페이셜 마스크를 처리한 그룹의 멜라닌 입자 세포와 DOPA 양성 멜라닌 세포의 평균 수를 나타낸 것이다.Table 1 shows the average number of melanin particle cells and DOPA positive melanocytes in the unirradiated group, the irradiated group, and the group treated with the facial mask according to Examples 1 to 13 of the present invention.
비교그룹과 비교할 때, UVB 조사에 노출된 두 번째 그룹은 더 높은 멜라닌 입자 세포 수와 DOPA 양성 멜라닌 세포를 가졌다.Compared with the comparative group, the second group exposed to UVB irradiation had higher melanin particle numbers and DOPA positive melanocytes.
본 발명의 실시예 1 내지 13으로 처리한 후에는, 표피의 멜라닌 입자 세포의 수 및 DOPA 양성 멜라닌 세포의 수는 비교그룹에 매우 근접한 수준으로 확연하게 감소하였다. 물론, 본 발명은 피부 미백 및 기미 (chloasma)를 제거하는데 우수한 효과를 나타냈다.After treatment with Examples 1 to 13 of the present invention, the number of melanin particles in the epidermis and the number of DOPA-positive melanocytes significantly decreased to a level very close to the comparative group. Of course, the present invention has shown an excellent effect in removing skin whitening and chloasma.
특히, 실시예 5는 멜라닌 세포 및 DOPA 양성 멜라닌 세포의 수 감소에 있어 실시예 1 내지 13 중 가장 좋은 효과를 보였고, 때때로 실시예 5는 비교그룹에 매우 가까운 수준에 도달하였다.In particular, Example 5 showed the best effect of Examples 1-13 in decreasing the number of melanocytes and DOPA-positive melanocytes, and occasionally Example 5 reached a level very close to the comparative group.
또한, 실시예 1, 11 및 12는 실시예 1을 제외한 다른 실시예들과 비교하였을 때 상대적으로 우수한 효과를 보였다.In addition, Examples 1, 11, and 12 showed relatively excellent effects when compared with the other Examples except for Example 1. [
본 발명의 페이셜 마스크는 인체의 피부, 특히 얼굴 피부에 국소 적용하기에 적합하다. 본 발명의 사용은 다양한 성분의 침착 및 침투 덕분에 피부에 매끄러움 (smoothness), 부드러움 (softness), 및 보습감 (moisturized feel)과 같은 피부 컨디셔닝 효과를 제공한다.The facial mask of the present invention is suitable for topical application to human skin, especially facial skin. The use of the present invention provides skin conditioning effects such as smoothness, softness, and moisturized feel to the skin due to the deposition and penetration of various ingredients.
본 발명의 이점은 만성 미백제와 같은 특정 효과제 (specific benefit agents)와 유화된 액체 조성을 포함하는 피부 효과제의 측면에서 (in view of) 본 발명의 마스크 조성물를 사용(application)함으로써 제공된다. 본 발명의 마스크 조성물은 영양성분 및 다른 효과제를 피부로 전달하는데 있어 특히 이롭다.The advantages of the present invention are provided by application of the mask composition of the present invention in view of a skin benefit agent comprising specific benefit agents such as a chronic whitening agent and an emulsified liquid composition. The mask composition of the present invention is particularly beneficial in delivering nutrients and other benefit agents to the skin.
물에 녹지 않는 기질 (substate)을 사용하지 않는 액체 조성물을 피부에 사용할 때와 비교하면, 장시간 이송 수단으로서 물에 녹지 않는 기질을 가진 본 발명의 마스크의 사용으로 특정 효과제, 피부 효과제와 같은 제제가 더 잘 분배 및 침전될 것이 기대되고, 피부를 통해 전달되는 이러한 제제들이 더 잘 투과될 것이 기대된다.Compared with the use of a liquid composition that does not use a water-insoluble substrate, the use of a mask of the present invention with a substrate that does not dissolve in water as a long-term delivery means, It is expected that the formulation will be better distributed and settled, and that these agents delivered through the skin will be better permeable.
또한, 낮은 공기 투과도를 가진 불용성 기질이 사용될 때, 피부 효과제의 피부로의 더 효과적인 침투가 기대된다. 본 발명의 마스크 조성물은 또한 이를 사용하는 사용자에게 청량감 (refreshing feel)과 안도감 (relaxation feel)과 같은 감정적인 효과를 제공할 것으로 기대된다.In addition, when an insoluble substrate with low air permeability is used, a more effective penetration of the skin benefit agent into the skin is expected. The mask composition of the present invention is also expected to provide emotional effects such as a refreshing feel and a relaxation feel to the user using it.
바람직한 일 실시예에 따르면, 마스크 조성물은 하기의 단계로 얼굴 피부를 치료하는데 사용될 수 있다: (a) 얼굴 피부 대부분의 영역에 마스크 조성물을 사용한다; (b) 마스크 조성물의 어느 한 부분이 마를 때까지보다 길지 않은 시간 동안 얼굴 피부 위에 놓는다; (c) 얼굴 피부에서 마스크 조성물을 제거한다; (d) 얼굴 피부에 남아있는 액체 조성물을 제거한다.According to one preferred embodiment, the mask composition can be used to treat facial skin by the following steps: (a) using a mask composition in most areas of the facial skin; (b) placing a portion of the mask composition on the facial skin for a time not longer than until dry; (c) removing the mask composition from the facial skin; (d) The liquid composition remaining on the facial skin is removed.
마스크 조성물은 수성 액체 조성물로 적셔지므로, 마스크가 피부에 부드럽게 배치되어 얼굴 피부에 알맞게 된다. 영양성분과 다른 피부효과제의 더욱 알맞고 동등한 분배를 위해, 마스크를 손끝을 사용해서 얼굴 피부와 밀착시킨다 (is pressed).Since the mask composition is soaked with an aqueous liquid composition, the mask is gently placed on the skin to make it suitable for facial skin. For a more even and even distribution of nutrients and other skin benefit agents, the mask is pressed against the face using the fingertips.
Claims (5)
8 to 13 parts by weight of angelica, 8 to 16 parts by weight of white atractylodes rhizome, 8 to 15 parts by weight of Bletilla hyacinthina Reichb powder, 9 to 16 parts by weight of astragalus mongholicus, 5 to 15 parts by weight of Ligusticum wallichii, 3 to 7 parts by weight of spirulina, 10 to 20 parts by weight of coix seed and 5 to 9 parts by weight of Barley Green.
8. The method according to claim 1, wherein 8 parts by weight of angelica, 8 parts by weight of white atractylodes rhizome, 8 parts by weight of Bletilla hyacinthina Reichb powder, 9 parts by weight of astragalus mongholicus, 5 parts by weight of Ligusticum wallichii, 3 parts by weight of spirulina, 10 parts by weight of coix seed and 5 parts by weight of Barley Green.
The method according to claim 1, wherein 10.5 parts by weight of angelica, 12 parts by weight of white atractylodes rhizome, 11.5 parts by weight of Bletilla hyacinthina Reichb powder, 12.5 parts by weight of astragalus mongholicus, 10 parts by weight of Ligusticum wallichii, 5 parts by weight of spirulina, 15 parts by weight of coix seed and 7 parts by weight of Barley Green.
The composition of claim 1, further comprising 12 parts by weight of angelica, 14 parts by weight of white atractylodes rhizome, 13 parts by weight of Bletilla hyacinthina Reichb powder, 13 parts by weight of astragalus mongholicus, 12 parts by weight of Ligusticum wallichii, 3 to 7 parts by weight of spirulina, 16 parts by weight of coix seed and 8 parts by weight of Barley Green.
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| KR1020160138156A KR20180044538A (en) | 2016-10-24 | 2016-10-24 | Facial mask |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102019104814A1 (en) | 2018-04-17 | 2019-10-17 | Doosan Heavy Industries & Construction Co., Ltd. | Turbine blade equipped with an insert carrier |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102019104814A1 (en) | 2018-04-17 | 2019-10-17 | Doosan Heavy Industries & Construction Co., Ltd. | Turbine blade equipped with an insert carrier |
| DE102019104814B4 (en) | 2018-04-17 | 2022-10-20 | Doosan Enerbility Co., Ltd. | Turbine blade equipped with an insert carrier |
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