KR20180043835A - 펩티도미메틱 매크로사이클 및 이의 용도 - Google Patents

펩티도미메틱 매크로사이클 및 이의 용도 Download PDF

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KR20180043835A
KR20180043835A KR1020187009277A KR20187009277A KR20180043835A KR 20180043835 A KR20180043835 A KR 20180043835A KR 1020187009277 A KR1020187009277 A KR 1020187009277A KR 20187009277 A KR20187009277 A KR 20187009277A KR 20180043835 A KR20180043835 A KR 20180043835A
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independently
active agent
pharmacologically active
cancer
peptidomimetic macrocycle
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Korean (ko)
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마누엘 아이바도
빈센트 게르라바이스
카렌 올슨
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에일러론 테라퓨틱스 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
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    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • C12Y—ENZYMES
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KR1020187009277A 2015-09-03 2016-09-02 펩티도미메틱 매크로사이클 및 이의 용도 Ceased KR20180043835A (ko)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201562214142P 2015-09-03 2015-09-03
US62/214,142 2015-09-03
US201662310254P 2016-03-18 2016-03-18
US62/310,254 2016-03-18
US201662344651P 2016-06-02 2016-06-02
US201662344791P 2016-06-02 2016-06-02
US62/344,651 2016-06-02
US62/344,791 2016-06-02
PCT/US2016/050194 WO2017040990A1 (en) 2015-09-03 2016-09-02 Peptidomimetic macrocycles and uses thereof

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KR20180043835A true KR20180043835A (ko) 2018-04-30

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US (2) US20170114098A1 (enExample)
EP (1) EP3344275B8 (enExample)
JP (1) JP6971970B2 (enExample)
KR (1) KR20180043835A (enExample)
CN (1) CN108348571B (enExample)
AU (1) AU2016315878A1 (enExample)
BR (1) BR112018003985A2 (enExample)
CA (1) CA2996685A1 (enExample)
IL (1) IL257706A (enExample)
MX (1) MX2018002723A (enExample)
WO (1) WO2017040990A1 (enExample)

Cited By (1)

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US12398176B2 (en) 2018-08-27 2025-08-26 Regeneron Pharmaceuticals, Inc. Use of Raman spectroscopy in downstream purification

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US7960506B2 (en) 2006-12-14 2011-06-14 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
CA2939778C (en) 2007-01-31 2019-01-29 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
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