KR20180031180A - A composition of plants extract for relief of symptoms of gastroesophageal reflux disease and manufacturing method for the same - Google Patents

A composition of plants extract for relief of symptoms of gastroesophageal reflux disease and manufacturing method for the same Download PDF

Info

Publication number
KR20180031180A
KR20180031180A KR1020160119207A KR20160119207A KR20180031180A KR 20180031180 A KR20180031180 A KR 20180031180A KR 1020160119207 A KR1020160119207 A KR 1020160119207A KR 20160119207 A KR20160119207 A KR 20160119207A KR 20180031180 A KR20180031180 A KR 20180031180A
Authority
KR
South Korea
Prior art keywords
weight
mixture
dandelion
symptoms
mixed extract
Prior art date
Application number
KR1020160119207A
Other languages
Korean (ko)
Inventor
이범상
신병익
Original Assignee
이범상
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 이범상 filed Critical 이범상
Priority to KR1020160119207A priority Critical patent/KR20180031180A/en
Publication of KR20180031180A publication Critical patent/KR20180031180A/en

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288Taraxacum (dandelion)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/78Saururaceae (Lizard's-tail family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/894Dioscoreaceae (Yam family)
    • A61K36/8945Dioscorea, e.g. yam, Chinese yam or water yam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to a composition of a plant mixed extract for relieving symptoms of gastroesophageal reflux disease and to a manufacturing method thereof, wherein the composition of the plant mixed extract for relieving the symptoms of the gastroesophageal reflux disease according to the present invention comprises: 5 to 10 wt% of a mixture obtained by mixing 30 to 40 wt% of Rhynchosia volubilis, 30 to 40 wt% of Oryza sativa and 30 to 40 wt% of Avena nuda; 5 to 35 wt% of Taraxacum platycarpum; 5 to 35 wt% of Saururus chinensis; 5 to 25 wt% of the bark of Ulmus macrocarpa; 5 to 25 wt% of Dioscorea batatas; 5 to 25 wt% of Crataegus pinnatifida; 5 to 10 wt% of Angelica gigas; 5 to 10 wt% of Citrus unshiu Markovich; 5 to 10 wt% of Lithospermum purpureo caeruleum; 5 to 10 wt% of Pueraria montana; 1 to 10 wt% of Syzygium aromaticum; and 1 to 10 wt% of dried Zingiber officinale.

Description

역류성 식도염의 증상완화를 위한 식물혼합추출 조성물 및 이의 제조방법{A composition of plants extract for relief of symptoms of gastroesophageal reflux disease and manufacturing method for the same}[0001] The present invention relates to a plant extract composition for relieving symptoms of reflux esophagitis and a method for producing the same,

본 발명은 역류성 식도염의 증상완화를 위한 식물혼합추출 조성물 및 이의 제조방법에 관한 것으로, 보다 구체적으로는 식도와 위를 편하게 하고 항염증의 효과가 있어 식도염 또는 위염의 증상을 완화시킬 수 있는 역류성 식도염의 증상완화를 위한 식물혼합추출 조성물 및 이의 제조방법에 관한 것이다.The present invention relates to a plant mixed extract composition for symptomatic relief of reflux esophagitis and more particularly to a method for producing a reflux esophagus which can alleviate symptoms of esophagitis or gastritis by relaxing the esophagus and stomach, And to a process for producing the same.

역류성 식도염(GRD : gastroesophageal reflux disease)은 유럽이나 미국과 같은 서구에서는 오래 전부터 흔한 질환이었는데 최근 식생활이나 생활습관의 서구화에 따라 우리나라에서도 점차 증가하고 있다.Gastroesophageal reflux disease (GRD) has been a long-standing disease in western countries such as Europe and the United States and has recently been increasing in Korea due to Westernization of diet and lifestyle.

가슴앓이가 가장 흔한 역류성 식도염의 증상이다. 이는 대개 명치 끝에서 목구멍 쪽으로 치밀어 오르는 듯한 타는 통증, 화끈거림, 쓰라린 느낌 또는 불쾌감을 말합니다. 이 증상은 등이나 목 쪽으로 뻗칠 수 있으며 음식을 삼키기 어렵다고 느끼는 연하곤란과 함께 나타날 수 있다.Heartburn is the most common symptom of reflux esophagitis. This usually refers to burning pain, burning, bitterness, or discomfort that seem to climb from the end of the stomach to the throat. This symptom can be spread to the back or neck and can be accompanied by dysphagia, which feels difficult to swallow.

산 역류도 중요한 증상인데 이는 신물이나 쓴물 혹은 소화된 음식물이 다시 입으로 넘어 오는 것을 말합니다. 때로는 가슴이 아프거나 음식이 걸리는 느낌이 발생되기도 하고 음식을 먹지 않을 때에도 목에 덩어리가 있다고 느끼기도 한다. 상복부(오목가슴)의 반복적인 통증이나 불편감 혹은 만성적인 기침도 역류성 식도염의 증상일 수 있다.Acid reflux is also an important symptom, which means that sickness, bitterness, or digestive food come back into your mouth. Sometimes the chest feels sick or hungry, and even when you do not eat, you may feel lumps in your neck. Repetitive pain or discomfort in the upper abdomen (concave chest) or chronic cough may also be a symptom of reflux esophagitis.

역류성 식도염의 가슴앓이는 하루 중 언제나 생길 수 있지만 주로 식사 후 혹은 누운 자세에서 심해지는 것이 중요한 특징이다. 흔히 속쓰림과 혼동되기도 하는데 이는 기능성 소화불량이나 위궤양 혹은 십이지장 궤양에서보다 자주 나타나는 증상으로 식사 전 즉 속이 비었을때 상복부(오목가슴)의 증상이 심해지는 경향이 있다. 따라서 역류성 식도염의 증상과 속쓰림은 매우 비슷하지만 그 위치와 발생하는 시간에 다소 차이가 있다.Heartburn in reflux esophagitis can occur any time of the day, but it is important to get worse after eating or lying down. It is often confused with heartburn, which is a more common symptom of functional dyspepsia or gastric ulcer or duodenal ulcer, which tends to increase the symptoms of the upper abdomen (the concave chest) before the meal is empty. Symptoms of reflux esophagitis and heartburn are very similar, but there is a slight difference in their location and time.

이 질환의 가장 큰 문제는 증상이 한번 생기면 대개 만성적으로 발전해 삶의 질을 떨어뜨릴 수 있다는 것. 목 이물감이 지속되면 만성 기침은 물론 이를 분해하기 위해 세균이 작용하며 구취가 발생해 단체생활에 지장을 받기도 하고, 누워있을 때 주로 증상이 생기기 때문에 가슴이 답답해 숙면을 취하기 어렵다. 또한 역류성식도염의 경우, 방치하면 드물지만 식도협착이나 식도암 등으로 발전할 수도 있다. 따라서 증상이 느껴지면 병원을 찾아 정확한 진단을 받고 치료를 하는 것이 무엇보다 중요하다. 특히, 단순히 위산을 억제하는 약물치료는 약을 중단하거나 용량을 줄이면 증상이 재발하는 경우가 많아 근본적인 치료와 식이조절이 필요하다.The biggest problem with this disease is that once it is symptomatic, it usually develops chronically and can reduce the quality of life. If the foreign body of the neck persists, the chronic cough, as well as the germs acting to break it off, cause bad breath and bad breath, and it is difficult to get a good night's sleep because of the symptoms. In the case of reflux esophagitis, it is rare to leave, but it may develop into esophageal stricture or esophageal cancer. Therefore, if you feel any symptoms, it is important to find a hospital and get the correct diagnosis and treatment. In particular, drug therapy that simply suppresses gastric acid requires frequent treatment and dietary control because of the frequent recurrence of symptoms when the drug is discontinued or the dose is reduced.

역류성 식도염의 치료에는 위산의 분비를 억제하는 여러 가지 약제가 사용이 되며, 가장 흔히 처방되는 약제는 오메프라졸이나 라베프라졸과 같은 수소펌프 억제제이다 이는 위산의 분비를 90% 이상 줄임으로써 비록 역류가 계속 일어나더라도 증상이 발생하지 않고 식도의 병변이 진행하는 것을 막아준다. 식도와 하부식도 괄약근의 운동성을 조절하는 약들도 사용되고 있으며, 위의 약제를 함께 사용하는 경우도 있다. 잔탁(Zantac), 마일란타(Mylanta)같은 약물을 사용하여 위산의 분비를 억제하거나 위산 위에 막을 씌워 위산이 올라오더라도 그 막이 식도를 미리 감싸 염증을 가라앉힌다. 염증 질환이라고 비스테로이드성 항염제 (Non-steroidal Antiinflammatory Drugs)를 사용하면 해당 항염제에 있는 위산분비 효과로 인해 속쓰림 등의 생길 수 있다. 아스피린, 부루펜(ibuprofen) 등의 약이 이에 속한다.In the treatment of reflux esophagitis, various drugs that inhibit the secretion of gastric acid are used. The most commonly prescribed drugs are hydrogen pump inhibitors such as omeprazole or rabeprazole. This reduces gastric secretion by more than 90% It does not cause symptoms even if you wake up, and prevents esophageal lesions from progressing. Drugs that control the motility of the esophagus and lower esophageal sphincter are also used, and some of the above medications may be used together. Zantac and Mylanta are used to inhibit the secretion of gastric acid or put a film on the stomach acid, even if the stomach acid up the membrane of the esophagus is wrapped around the inflammation. The use of non-steroidal antiinflammatory drugs (NSAIDs), which are inflammatory diseases, can cause heartburn due to gastric acid secretion in the corresponding anti-inflammatory drugs. Aspirin, and ibuprofen.

위의 여러 방법으로도 증상의 호전이 없는 경우에는 수술을 권유 받게 된다. 몇 가지 합병증이 생겨서 수술을 받는 경우도 있지만 이런 경우는 매우 드문 편이다. 최근에는 배나 가슴을 열지 않고 복강경을 이용한 수술법이 개발되어 있다.If the symptoms are not improved by any of the above methods, surgery is recommended. Some complications have occurred and some have undergone surgery, but this is rare. Recently, laparoscopic surgery has been developed without opening the abdomen or the chest.

이상에서 보는 바와 같이 화학합성 약물치료와 수술요법과 외에 역류성 식도염 환자에게 부작용이 덜하고 영양까지 공급해주는 것이 매우 중요함으로 환자의 건강과 치료까지 함께 실현할 수 있으면서도 부작용이 없는 식물 추출 혼합조성물의 개발이 필요한 실정이다.As shown above, it is very important to provide chemotherapeutic drug treatment and surgical treatment as well as less side effects and reflux to patients with reflux esophagitis. Therefore, development of a plant extract mixture composition which can realize both patient's health and treatment, It is necessary.

대한민국 등록특허공보 제10-1521125호(2015.05.12.)Korean Registered Patent No. 10-1521125 (May 5, 2015)

따라서, 본 발명의 목적은 상기한 종래의 문제점을 극복할 수 있는 역류성 식도염의 증상완화를 위한 식물혼합추출 조성물 및 이의 제조방법을 제공하는 데 있다.Accordingly, it is an object of the present invention to provide a plant mixed extract composition for relieving symptoms of reflux esophagitis, which can overcome the above-described conventional problems, and a method for producing the same.

본 발명의 다른 목적은 항염증 효능이 있어 식도염 및 위염 증상을 완화시킬 수 있는 역류성 식도염의 증상완화를 위한 식물혼합추출 조성물 및 이의 제조방법을 제공하는 데 있다.Another object of the present invention is to provide a plant mixed extract composition for alleviating symptoms of reflux esophagitis which has anti-inflammatory effect and can alleviate esophagitis and gastritis symptoms, and a method for producing the same.

상기한 기술적 과제들의 일부를 달성하기 위한 본 발명의 구체화에 따라, 본 발명에 따른 역류성 식도염의 증상완화를 위한 식물혼합추출 조성물은, 서목태 30~40 중량%, 현미 30~40 중량%, 및 큰쌀귀리 30~40 중량%를 혼합하여 제조한 혼합물 5~10 중량%와; 민들레 5~35 중량%와; 삼백초 5~35 중량%와; 왕느릅나무 껍질 5~25 중량%와; 산약 5~25 중량%와; 산사 5~25 중량%와; 당귀 5~10 중량%와; 진피(陳皮) 5~10 중량%와; 지치 5~10 중량%와; 칡 5~10 중량%와; 정향 1~10 중량%와; 건생강 1~10 중량%를 포함한다.According to the embodiment of the present invention, the plant mixed extract composition for symptom relief of reflux esophagitis according to the present invention comprises 30 to 40% by weight of Seomyeongtae, 30 to 40% by weight of brown rice, 5 to 10% by weight of a mixture prepared by mixing 30 to 40% by weight of oats; 5 to 35% by weight of dandelion; 5 to 35% by weight of Saururus chinensis; 5 to 25% by weight of the elm bark; 5 to 25% by weight of an acid; 5 to 25% by weight of persimmon; 5 to 10% by weight of Angelica gigas; 5 to 10% by weight of dyes; 5 to 10% by weight of a feces; 5 to 10% by weight; 1 to 10% by weight of clove; And 1 to 10% by weight of dry ginger.

상기한 기술적 과제들의 일부를 달성하기 위한 본 발명의 다른 구체화에 따라, 본 발명에 따른 역류성 식도염의 증상완화를 위한 식물혼합추출 조성물의 제조방법은, 서목태 30~40 중량%, 현미 30~40 중량%, 및 큰쌀귀리 30~40 중량%를 혼합하여 제조한 제1혼합물을 제조하는 제1단계와; 상기 제1혼합물 5~10 중량%와, 민들레 5~35 중량%와, 삼백초 5~35 중량%와, 왕느릅나무 껍질 5~25 중량%와, 산약 5~25 중량%와, 산사 5~25 중량%와, 당귀 5~10 중량%와, 진피(陳皮) 5~10 중량%와, 지치 5~10 중량%와, 칡 5~10 중량%와, 정향 1~10 중량%와, 건생강 1~10 중량%를 혼합하여 분말화하여 제2혼합물을 제조하는 제2단계와; 상기 제2혼합물에 올리고당을 상기 제2혼합물 대비 10~30 중량% 만큼 넣어 혼합하여 제3혼합물을 제조하는 제3단계와; 상기 제3혼합물을 숙성고에서 20~30℃의 온도 하에서 12~24시간 동안 숙성 및 발효시켜 제4혼합물을 제조하는 제4단계와; 숙성 및 발효된 상기 제4혼합물을 반죽하고 성형틀에 넣어 성형한 후 건조시키는 제5단계를 구비한다.According to another embodiment of the present invention, there is provided a method for preparing a plant mixed extract composition for relieving symptom of reflux esophagitis, which comprises 30 to 40% by weight of Seomyeongtae, 30 to 40% by weight of brown rice %, And 30 to 40% by weight of oat flour; 5 to 35 weight% of dandelion, 5 to 35 weight% of dandelion, 5 to 25 weight% of royal elm shell, 5 to 25 weight% of dandelion, 5 to 25 weight% of dandelion, 5 to 25 weight% , 5 to 10 wt% of dicalcium phosphate, 5 to 10 wt% of dicalcium phosphate, 5 to 10 wt% of dandelion, 5 to 10 wt% of drench, 5 to 10 wt% of drench, 1 to 10 wt% To 10% by weight of the first mixture and pulverizing the mixture to prepare a second mixture; Mixing the oligosaccharide with the second mixture in an amount of 10 to 30% by weight to prepare a third mixture; A fourth step of aging and fermenting the third mixture under aged conditions at a temperature of 20 to 30 ° C for 12 to 24 hours to prepare a fourth mixture; And a fifth step of kneading the fermented and fermented fourth mixture, molding the mixture into a molding mold, and drying the resultant.

상기 제1단계의 상기 제1혼합물은, 서목태 30~40 중량%, 현미 30~40 중량%, 및 큰쌀귀리 30~40 중량%를 혼합하여 혼합물을 제조하는 단계와; 상기 혼합물의 2~4배의 중량에 해당되는 현미식초를 상기 혼합물에 넣어 혼합한 후 밀폐용기에 넣어 10~30일 동안 그늘에서 숙성 및 발효시키는 단계와; 숙성 및 발효된 혼합물을 자연건조 또는 열풍건조 방식으로 건조시키는 단계를 통해 제조될 수 있다.Wherein the first mixture of the first step comprises 30 to 40 wt% of Pseudomonas species, 30 to 40 wt% of brown rice, and 30 to 40 wt% of Pseudomonas species; Adding the brown rice vinegar corresponding to 2 to 4 times the weight of the mixture to the mixture, aging the mixture in a shade for 10 to 30 days in an airtight container, and fermenting the mixture; Aging and fermenting the mixture by natural drying or hot-air drying method.

상기 제5단계에서, 상기 제4혼합물의 반죽시에, 찹쌀풀, 올리고당, 및 꿀이 부용제로 첨가될 수 있다. In the fifth step, at the time of kneading the fourth mixture, glutinous rice flour, oligosaccharides, and honey may be added as a diluent.

본 발명에 따른 역류성 식도염의 증상완화를 위한 식물혼합추출 조성물은 항염증 효능으로 역류성 식도염 및 위염 증상을 완화시키는 효능이 있으며, 체내노페물이나 중금속등을 배출 및 해독시키고, 혈액정화, 항암효과. 항바이러스효과, 항산화효과, 식욕증진, 권태감회복, 심장기능강화 등을 효능을 가진다. 또한, 대장의 노폐물인 숙변이 제거되면서, 소장과 위장에 머물러 있는 음식물과 노폐물이 배변으로 자연스럽게 나오게 하는 쾌변효능, 즉각적인 위장의 부담을 줄여 역류성 식도염 과 위하수에 좋은 효과를 주며, 혈액 및 기타 체내에 있는 독소들이 배출되는 효능을 가진다. The plant mixed extract composition for relieving the symptom of reflux esophagitis according to the present invention is effective for alleviating the symptoms of reflux esophagitis and gastritis by the anti-inflammatory effect, and discharges and detoxifies the body's nopheles and heavy metals. Anti-viral effect, antioxidant effect, appetite enhancement, restoration of bodily sensation, and strengthening of heart function. In addition, as the waste of the colon is removed, the food and waste residing in the small intestine and the stomach are naturally released into the bowel, thereby reducing the burden of the immediate gastrointestinal tract and thus providing a good effect on the reflux esophagitis and gastric ulcer. The toxins have the potential to be released.

도 1은 본 발명의 실시예에 따른 역류성 식도염의 증상완화를 위한 식물혼합추출 조성물의 제조방법을 나타낸 순서도이다.FIG. 1 is a flowchart illustrating a method for producing a plant mixed extract composition for symptom relief of reflux esophagitis according to an embodiment of the present invention.

이하에서는 본 발명의 바람직한 실시예가, 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자에게 본 발명의 철저한 이해를 제공할 의도 외에는 다른 의도 없이, 첨부한 도면들을 참조로 하여 상세히 설명될 것이다.DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings without intending to intend to provide a thorough understanding of the present invention to a person having ordinary skill in the art to which the present invention belongs.

도 1은 본 발명의 실시예에 따른 역류성 식도염의 증상완화를 위한 식물혼합추출 조성물의 제조방법을 나타낸 순서도이다.FIG. 1 is a flowchart illustrating a method for producing a plant mixed extract composition for symptom relief of reflux esophagitis according to an embodiment of the present invention.

도 1에 도시된 바와 같이, 본 발명의 실시예에 따른 역류성 식도염의 증상완화를 위한 식물혼합추출 조성물은 다음과 같은 공정에 의해 제조된다.As shown in FIG. 1, a plant mixed extract composition for symptom relief of reflux esophagitis according to an embodiment of the present invention is prepared by the following process.

우선 제1혼합물을 제조한다(S110). 상기 제1혼합물은 서목태(또는 약콩) 30~40 중량%, 현미(또는 발아현미) 30~40 중량%, 및 큰쌀귀리 30~40 중량%를 혼합하여 제조한다.First, a first mixture is prepared (S110). The first mixture is prepared by mixing 30 to 40% by weight of pomegranate (or soybean paste), 30 to 40% by weight of brown rice (or germinated brown rice), and 30 to 40% by weight of oatmeal.

구체적으로 상기 제1혼합물은, 서목태(또는 약콩) 30~40 중량%, 현미(또는 발아현미) 30~40 중량%, 및 큰쌀귀리 30~40 중량%를 혼합하여 혼합물을 제조하고, 이 혼합물의 2~4배의 중량에 해당되는 현미식초 또는 식초를 상기 혼합물에 넣어 혼합한 후 숙성 및 발효시키게 된다. 여기서 숙성 및 발효는 상기 현미식초 또는 식초를 넣은 혼합물을 밀폐용기에 넣어 10~30일 동안 그늘에 보관하는 방법으로 수행되게 된다. 이후 숙성 및 발효된 혼합물을 자연건조 또는 열풍건조 방식으로 건조시켜 상기 제1혼합물을 완성하게 된다.Specifically, the first mixture is prepared by mixing 30 to 40% by weight of the pomegranate (or soybean paste), 30 to 40% by weight of brown rice (or germinated brown rice), and 30 to 40% The brown rice vinegar or vinegar corresponding to 2 to 4 times the weight is added to the mixture, and the mixture is aged and fermented. Here, the fermentation and fermentation are carried out by placing the mixture containing the brown rice vinegar or vinegar in a sealed container and storing the mixture in the shade for 10 to 30 days. Thereafter, the aged and fermented mixture is dried by natural drying or hot air drying to complete the first mixture.

이후 제2혼합물을 제조한다(S120).Thereafter, a second mixture is prepared (S120).

상기 제2혼합물은 상기 제1혼합물 5~10 중량%와, 민들레 5~35 중량%와, 삼백초 5~35 중량%와, 왕느릅나무 껍질 5~25 중량%와, 산약 5~25 중량%와, 산사 5~25 중량%와, 당귀 5~10 중량%와, 진피(陳皮) 5~10 중량%와, 지치 5~10 중량%와, 칡 5~10 중량%와, 정향 1~10 중량%와, 건생강 1~10 중량%를 혼합하고 분말화하여 제조하게 된다.Wherein the second mixture comprises 5 to 10% by weight of the first mixture, 5 to 35% by weight of dandelion, 5 to 35% by weight of 3 to 500 milliwatts, 5 to 25% 5 to 10% by weight of dicalcium phosphate, 5 to 10% by weight of dicalcium phosphate, 5 to 10% by weight of cinnabarin, 5 to 10% And 1 to 10% by weight of dried ginger are mixed and powdered.

여기서 민들레는 포공영이라고도 불리며 국화과의 민들레(Taraxacum platycarpum H. Dahlstedt) 또는 동속 식물의 전초를 말린 약재를 말하고, 삼백초는 뿌리, 잎, 꽃이 흰색이기 때문에 삼백초라고 불리며, 해독제나 이뇨제의 효능이 있는 것으로 알려져 있다. 왕느릅나무 껍질은 유백피라고도 불리며, 항염효과가 있는 것으로 알려져 있다. 산약은 마과 식물인 마 또는 참마의 덩이뿌리를 말린 것으로, 원기와 비위(脾胃)를 북돋우고 설사를 멎게 하며 진액을 생기게 하는 효능이 있는 것으로 알려져 있다.Here, dandelion is also referred to as Pongolian, and refers to a dandelion (Taraxacum platycarpum H. Dahlstedt) or a herb that has dried outposts of the same plants. Saururus is called Saururus chinensis because its roots, leaves and flowers are white and has an antidote or diuretic effect It is known. The elm bark is also called milky white, and is known to have anti-inflammatory properties. It is said to be effective in revitalizing the stomach and stomach, stopping the diarrhea and causing the juice.

그리고, 산사나무 열매는 열매가 사과맛이 나고 색이 붉어 작은 사과와 같아서 붙여진 이름으로 비위를 따뜻하게 하여 소화를 촉진하며 고기를 먹고 체했을때 효과가 있고 복통, 구토, 설사, 위산과다, 만성장염등에 효능이 있는 것으로 알려져 있다.And the fruit of the horsetail is fruit when it is apple and it is red and it is like a little apple and it is warmed by the name which is attached and promotes the digestion and it is effective when it eats and slaughtered meat, and it is effective when it is abdominal pain, vomiting, diarrhea, And is known to have efficacy.

당귀는 피가 부족할 때 피를 생성해 주는 보혈 작용(補血作用)이 있는 것으로 알려져 있으며, 진피는 귤껍질로 한방에서 속이 더부룩하거나 답답할 때 소화가 잘 되게 도와준다고 알려져 있다. 또한, 지치는 자초 또는 지초라고도 불리며 열을 내리고 혈액순환을 돕고 항염효과가 있는 약재로 알려져 있다.It is known that Angelica gigas have a blood-producing (blood-clotting) effect when blood is scarce, and the dermis is known to help digestion when it is tangled or tangled in a herb with a tangerine peel. It is also known as a tired seed or worm, and it is known as a medicinal product that helps to lower the fever and help circulation and has anti-inflammatory effect.

칡은 갈근이라고도 불리며 칡뿌리를 말하는 것으로, 발열, 구토, 설사 등에 효능이 있는 것으로 알려져 있으며, 항염증 작용이 알려져 있다.칡 is also called Puerariae, and refers to 칡 root, which is known to be effective for fever, vomiting, diarrhea, and has anti-inflammatory action.

정향은 정향나무과의 정향(Syzygium aromaticum Merrill et Perry:丁香)의 꽃봉오리를 말하는 것으로, 위액분비촉진, 진통, 항경련, 항염, 항산화, 항혈전, 항균, 구충, 혈압강하의 효능이 있는 것으로 알려져 있다. It is said that the clove has the effect of promoting gastric secretion, analgesic, anticonvulsant, anti-inflammation, antioxidant, anti-thrombotic, antibacterial, antiparasitic and hypotensive effects, which refers to the bud of Syzygium aromaticum Merrill et Perry have.

건생강은 말린 생강을 의미하는 것으로, 소화가 안되며 구토, 설사를 하는 증상에 효과가 있는 것을 알려져 있다.Ginger refers to dried ginger, which is not digestible and is known to be effective in vomiting and diarrhea.

이때 각 재료별로 법제가 필요하면 법제를 한다. 여기서 법제란 자연 상태의 식물이나 동물, 광물 등을 약으로 사용하기 위해 처리하는 과정을 말한다. 부피가 큰 것은 나누고 단단한 것은 무르게 하며 독성이 있으면 제거하는 등 다양한 방법이 동원된다. 치료효과를 높이거나 새로운 효능을 내기 위해서도 필요하다.At this time, if each material requires a legal system, the legal system is applied. The term "legal system" refers to the process of treating plants, animals, and minerals in nature to use them as drugs. Bulky items can be divided and hardened, and toxic substances can be removed. It is also necessary to increase the therapeutic effect or to obtain new efficacy.

이후 분말 상태의 상기 제2혼합물에, 올리고당을 넣어 골고루 혼합하여 제3혼합물을 제조한다(S130).Thereafter, the oligosaccharide is added to the second mixture in a powdery state to prepare a third mixture (S130).

상기 올리고당은 상기 제2혼합물 대비 10~30 중량% 에 해당하는 만큼 넣게 된다. The oligosaccharide is added in an amount corresponding to 10 to 30% by weight of the second mixture.

이후 상기 제3혼합물을 숙성고에서 20~30℃의 온도 하에서 12~24시간 동안 숙성 및 발효시켜 제4혼합물을 제조하게 된다(S140).Thereafter, the third mixture is aged and fermented at a temperature of 20 to 30 ° C for 12 to 24 hours in an aged hull to produce a fourth mixture (S140).

이후 숙성 및 발효된 제4혼합물을 반죽기에 넣어 반죽하고, 성형틀에 넣어 녹두대로 성형하고 이를 건조하여 완성한다(S150). 여기서 녹두대(綠豆大) 란 녹두의 낟알만 한 환약(丸藥)의 크기를 말한다.Thereafter, the aged and fermented fourth mixture is put into a kneader, kneaded, molded into a mold, molded into a mung bean, and dried (S150). Here, the mung bean (綠豆 大) refers to the size of the pung (丸 薬) only the grain of the mung bean.

여기서, 상기 제4혼합물의 반죽시에, 찹쌀풀, 올리고당, 및 꿀이 부용제로 첨가될 수 있다.Here, at the time of kneading the fourth mixture, glutinous rice paste, oligosaccharide, and honey may be added as an additive.

상술한 바와 같이, 환약형태로 건조되어 완성된 본 발명에 따른 역류성 식도염의 증상완화를 위한 식물혼합추출 조성물은 항염증 효능으로 역류성 식도염 및 위염 증상을 완화시키는 효능이 있으며, 체내노페물이나 중금속등을 배출 및 해독시키고, 혈액정화, 항암효과. 항바이러스효과, 항산화효과, 식욕증진, 권태감회복, 심장기능강화 등을 효능을 가진다. As described above, the plant mixed extract composition for relieving symptoms of reflux esophagitis according to the present invention, dried and completed in the form of pills, has an anti-inflammatory effect and is effective for alleviating the symptoms of reflux esophagitis and gastritis. Discharge and detoxify, blood purification, anti-cancer effect. Anti-viral effect, antioxidant effect, appetite enhancement, restoration of bodily sensation, and strengthening of heart function.

또한, 대장의 노폐물인 숙변이 제거되면서, 소장과 위장에 머물러 있는 음식물과 노폐물이 배변으로 자연스럽게 나오게 하는 쾌변효능, 즉각적인 위장의 부담을 줄여 역류성 식도염 과 위하수에 좋은 효과를 주며, 혈액 및 기타 체내에 있는 독소들이 배출되는 효능을 가진다. In addition, as the waste of the colon is removed, the food and waste residing in the small intestine and the stomach are naturally released into the bowel, thereby reducing the burden of the immediate gastrointestinal tract and thus providing a good effect on the reflux esophagitis and gastric ulcer. The toxins have the potential to be released.

상기한 실시예의 설명은 본 발명의 더욱 철저한 이해를 위하여 도면을 참조로 예를 든 것에 불과하므로, 본 발명을 한정하는 의미로 해석되어서는 안될 것이다. 또한, 본 발명이 속하는 기술 분야에서 통상의 지식을 가진 자에게 있어 본 발명의 기본적 원리를 벗어나지 않는 범위 내에서 다양한 변화와 변경이 가능함은 명백하다 할 것이다. The foregoing description of the embodiments is merely illustrative of the present invention with reference to the drawings for a more thorough understanding of the present invention, and thus should not be construed as limiting the present invention. It will be apparent to those skilled in the art that various changes and modifications may be made without departing from the basic principles of the present invention.

Claims (4)

서목태 30~40 중량%, 현미 30~40 중량%, 및 큰쌀귀리 30~40 중량%를 혼합하여 제조한 혼합물 5~10 중량%와; 민들레 5~35 중량%와; 삼백초 5~35 중량%와; 왕느릅나무껍질 5~25 중량%와; 산약 5~25 중량%와; 산사나무 열매 5~25 중량%와; 당귀 5~10 중량%와; 진피(陳皮) 5~10 중량%와; 지치 5~10 중량%와; 칡 5~10 중량%와; 정향 1~10 중량%와; 건생강 1~10 중량%를 포함하는 것을 특징으로 하는 역류성 식도염의 증상완화를 위한 식물혼합추출 조성물.5 to 10% by weight of a mixture prepared by mixing 30 to 40% by weight of Seomotai, 30 to 40% by weight of brown rice, and 30 to 40% by weight of Oat rice; 5 to 35% by weight of dandelion; 5 to 35% by weight of Saururus chinensis; 5 to 25% by weight of the elm bark; 5 to 25% by weight of an acid; From 5 to 25% by weight of horseradish; 5 to 10% by weight of Angelica gigas; 5 to 10% by weight of dyes; 5 to 10% by weight of a feces; 5 to 10% by weight; 1 to 10% by weight of clove; And 1 to 10% by weight of dry ginger. The present invention relates to a plant mixed extract composition for symptom relief of reflux esophagitis. 서목태 30~40 중량%, 현미 30~40 중량%, 및 큰쌀귀리 30~40 중량%를 혼합하여 제조한 제1혼합물을 제조하는 제1단계와;
상기 제1혼합물 5~10 중량%와, 민들레 5~35 중량%와, 삼백초 5~35 중량%와, 왕느릅나무 껍질 5~25 중량%와, 산약 5~25 중량%와, 산사 5~25 중량%와, 당귀 5~10 중량%와, 진피(陳皮) 5~10 중량%와, 지치 5~10 중량%와, 칡 5~10 중량%와, 정향 1~10 중량%와, 건생강 1~10 중량%를 혼합하여 분말화하여 제2혼합물을 제조하는 제2단계와;
상기 제2혼합물에 올리고당을 상기 제2혼합물 대비 10~30 중량% 만큼 넣어 혼합하여 제3혼합물을 제조하는 제3단계와;
상기 제3혼합물을 숙성고에서 20~30℃의 온도 하에서 12~24시간 동안 숙성 및 발효시켜 제4혼합물을 제조하는 제4단계와;
숙성 및 발효된 상기 제4혼합물을 반죽하고 성형틀에 넣어 성형한 후 건조시키는 제5단계를 구비함을 특징으로 하는 역류성 식도염의 증상완화를 위한 식물혼합추출 조성물의 제조방법.
A first step of preparing a first mixture prepared by mixing 30 to 40% by weight of Seomotai, 30 to 40% by weight of brown rice, and 30 to 40% by weight of Oat rice;
5 to 35 weight% of dandelion, 5 to 35 weight% of dandelion, 5 to 25 weight% of royal elm shell, 5 to 25 weight% of dandelion, 5 to 25 weight% of dandelion, 5 to 25 weight% , 5 to 10 wt% of dicalcium phosphate, 5 to 10 wt% of dicalcium phosphate, 5 to 10 wt% of dandelion, 5 to 10 wt% of drench, 5 to 10 wt% of drench, 1 to 10 wt% To 10% by weight of the first mixture and pulverizing the mixture to prepare a second mixture;
Mixing the oligosaccharide with the second mixture by 10 to 30% by weight to prepare a third mixture;
A fourth step of aging and fermenting the third mixture under aged conditions at a temperature of 20 to 30 ° C for 12 to 24 hours to prepare a fourth mixture;
And a fifth step of kneading the fermented and fermented fourth mixture, molding the mixture into a molding mold, and then drying the resultant. The method of manufacturing a plant mixed extract composition for relieving symptoms of reflux esophagitis.
청구항 2에 있어서, 상기 제1단계의 상기 제1혼합물은,
서목태 30~40 중량%, 현미 30~40 중량%, 및 큰쌀귀리 30~40 중량%를 혼합하여 혼합물을 제조하는 단계와;
상기 혼합물의 2~4배의 중량에 해당되는 현미식초를 상기 혼합물에 넣어 혼합한 후 밀폐용기에 넣어 10~30일 동안 그늘에서 숙성 및 발효시키는 단계와;
숙성 및 발효된 혼합물을 자연건조 또는 열풍건조 방식으로 건조시키는 단계를 통해 제조됨을 특징으로 하는 역류성 식도염의 증상완화를 위한 식물혼합추출 조성물의 제조방법.
3. The method of claim 2, wherein the first mixture in the first step comprises:
30 to 40% by weight of Seomotai, 30 to 40% by weight of brown rice, and 30 to 40% by weight of Oat rice;
Adding the brown rice vinegar corresponding to 2 to 4 times the weight of the mixture to the mixture, aging the mixture in a shade for 10 to 30 days in an airtight container, and fermenting the mixture;
Wherein the mixture is aged and the fermented mixture is dried naturally or by a hot air drying method. The method for producing a plant mixed extract composition for symptom relief of reflux esophagitis.
청구항 2에 있어서,
상기 제5단계에서, 상기 제4혼합물의 반죽시에, 찹쌀풀, 올리고당, 및 꿀이 부용제로 첨가됨을 특징으로 하는 역류성 식도염의 증상완화를 위한 식물혼합추출 조성물의 제조방법.
The method of claim 2,
Wherein the glutinous rice paste, the oligosaccharide, and the honey are added as an additive agent when the fourth mixture is kneaded in the fifth step.
KR1020160119207A 2016-09-19 2016-09-19 A composition of plants extract for relief of symptoms of gastroesophageal reflux disease and manufacturing method for the same KR20180031180A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020160119207A KR20180031180A (en) 2016-09-19 2016-09-19 A composition of plants extract for relief of symptoms of gastroesophageal reflux disease and manufacturing method for the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020160119207A KR20180031180A (en) 2016-09-19 2016-09-19 A composition of plants extract for relief of symptoms of gastroesophageal reflux disease and manufacturing method for the same

Publications (1)

Publication Number Publication Date
KR20180031180A true KR20180031180A (en) 2018-03-28

Family

ID=61901486

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020160119207A KR20180031180A (en) 2016-09-19 2016-09-19 A composition of plants extract for relief of symptoms of gastroesophageal reflux disease and manufacturing method for the same

Country Status (1)

Country Link
KR (1) KR20180031180A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210002168A (en) * 2019-06-26 2021-01-07 재단법인 강릉과학산업진흥원 Functional beverage composition for gastro-health comprising sodium alginate as an active ingredient and the method for preparing the same
KR20220001553A (en) * 2020-06-29 2022-01-06 강기원 Composition for prevention and improvment of reflux esophagitis

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210002168A (en) * 2019-06-26 2021-01-07 재단법인 강릉과학산업진흥원 Functional beverage composition for gastro-health comprising sodium alginate as an active ingredient and the method for preparing the same
KR20220001553A (en) * 2020-06-29 2022-01-06 강기원 Composition for prevention and improvment of reflux esophagitis

Similar Documents

Publication Publication Date Title
KR20180031180A (en) A composition of plants extract for relief of symptoms of gastroesophageal reflux disease and manufacturing method for the same
WO2005007179A1 (en) Composition containing ground lotus and/or lotus extract and lactic acid bacterium
CN103431260B (en) Mixed-grain full-nutrition formulation food for patients with gastrointestinal tract malabsorption and pancreatitis
KR101808328B1 (en) Composition for improvement and prevention of gastroesophageal reflux disease and method for preparing the same
KR20140093461A (en) Mint liquid for improving digestive functions and manufacturing method thereof
CN101569655B (en) Radix astragali gastric floating tablet suitable for treating chronic superficial gastritis
KR20020089081A (en) Composition for helicobacter pylori-extermination and producing method thereof
CN101612218B (en) Medicated wine for treating gastropathy and piles
CN101347463A (en) Medicament composition for preventing relapse and for treating gastric ulcer
CN102698144B (en) Traditional Chinese medicine composition for treating gasteremphraxis
CN103861007A (en) Chinese herbal medicine compound preparation for treating diarrhea of chicken
CN107496532A (en) A kind of Chinese medicine composition for treating chicken dysentery and preparation method thereof
CN109833305A (en) Perfume connects the preparation process of antidiarrheal enteric-coated micro-pill
CN106421745A (en) Combined reagent for treating constipation and removing toxins in intestinal tracts
CN109700995B (en) A pharmaceutical composition for treating peptic ulcer, and its preparation method
CN107510771B (en) Traditional Chinese medicine composition for treating duck aeromonas hydrophila disease
CN105944089A (en) Capsule for treating atrophic gastritis and preparation method thereof
CN114652768A (en) Pharmaceutical composition and preparation method and application thereof
CN108379471A (en) A kind of drug for treating gaseous distention
CN104138587A (en) Sea cucumber composite powder used for preventing and treating stomach illness
CN104491338A (en) Edible and medicinal dual-purpose composition for relaxing bowels and preparation method thereof
CN101647977A (en) Medicine for treating gastrointestinal diseases
CN104147528B (en) A kind of preparation method for the medicine for treating gastric ulcer
CN108653599A (en) A kind of drug and preparation method thereof for treating enteritis, diarrhea
CN111012828A (en) Traditional Chinese medicine composition for invigorating spleen to promote digestion and application thereof in preparation of spleen-invigorating and digestion-promoting medicine

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E601 Decision to refuse application