KR20180019637A - Composition for prevention or treatment of oral disease comprising Viola mandshurica extract - Google Patents

Abstract

The present invention relates to a composition for preventing, alleviating or treating oral disease comprising a Viola mandshurica extract and, more specifically, to a composition for preventing, alleviating or treating oral disease, which is safe to the human body and has excellent effects.

Description

TECHNICAL FIELD The present invention relates to a composition for prevention or treatment of oral diseases,

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition for oral care, and more particularly, to a composition which is safe for the human body and is excellent in preventing, improving or treating oral diseases such as acne.

This symptom is caused by exposure of many of the tubules existing in the dentin of the tooth to the outside as the dentin part of the exposed tooth is sensed when the dentin part of the exposed tooth comes into contact with cold air or irritating food or the like. Symptoms of toothache can range from mild symptoms to severe and persistent pain. In addition, since teeth are not regenerated by nature, the use of analgesics or anti-inflammatory agents is not a fundamental solution to the symptoms of achene, and various therapies have been developed to relieve symptoms of achene. Among them, toothpaste for preventing acne symptoms is being developed, and the treatment of dentinal tubules exposed by dentistry is completed with resin. However, a conventional toothpaste using a conventional ivory tubular sealing effect contains a fine powder of an effective ingredient to seal the ivory tubule. In general, the toothpaste is diluted in the process of brushing, and is washed away most of the time in the course of rinsing with water There is a problem in that the customs pipe is not sealed and exposed again.

Accordingly, the present inventors have conducted studies to derive a component which is harmless to the human body and has excellent silylation-reducing effect, without concern for side effects.

SUMMARY OF THE INVENTION Accordingly, the present invention has been made to solve the above problems and to provide a composition for alleviating or ameliorating sirens using a naturally occurring ingredient which is safe and safe for human use with few side effects.

The present invention provides a composition for oral cavity, which can relieve symptoms of acne by forming a coating film on the surface of a damaged tooth using a natural material.

In order to solve the above problems, the present invention provides an oral composition derived from a natural substance. Specifically, in one embodiment of the present invention, there is provided an oral composition comprising a magnetization designation ( Viola mandshurica ) as an active ingredient.

That is, the present invention provides a new application for oral compositions containing a magnetization designation, especially oral compositions for preventing, improving or treating various oral diseases.

The inventors of the present invention have conducted studies for development of an oral composition capable of exhibiting effects on the treatment, prevention and amelioration of diseases in the oral cavity by harmless to human body. In particular, Effect and a tooth surface coating effect, thereby completing the present invention. Through the continuous research process of the inventors of the present invention, it was possible to first identify the therapeutic or preventive effect of the Magnetized Design Extract of the present invention on oral diseases.

The method of using the magnetization designation is not particularly limited, and may be included in the composition for oral use as a powder after drying, preferably as an extract, and may be contained in the oral composition.

As used herein, the term "extract" means an extract obtained by extraction of magnetization designation, a diluted solution or concentrate of the extract, a dried product obtained by drying the extract, a controlled preparation or purified product of the extracted solution, , The extract itself and extracts of all the formulations that can be formed using the extract.

The magnetization designation extract of the present invention can be extracted from the natural, hybrid, or variegated plant of the magnetization designation.

In the magnetization designation extract of the present invention, the method of extracting the magnetization designation is not particularly limited, and may be extracted according to a method commonly used in the art. Examples of the extraction method include hydrothermal extraction method, ultrasonic extraction method, filtration method, and reflux extraction method. These methods may be carried out singly or in combination of two or more methods, preferably using a hot water extraction method .

The kind of the extraction solvent used for extracting the magnetization designation in the present invention is not particularly limited and any solvent known in the art can be used. Nonlimiting examples of the extraction solvent include water, distilled water, methanol, ethanol, propanol, isopropanol, butanol, acetone, ether, benzene, chloroform, ethyl acetate, methylene chloride, n-hexane, hydrochloric acid, And cyclohexane. When alcohol is used as a solvent, C ₁ to C ₄ alcohols (methanol, ethanol, propanol, butanol) can be preferably used. In the present invention, water, ethanol or a mixture thereof may be more preferably used as the extraction solvent for the magnetization designation.

In the present invention, the composition may be for preventing, improving or treating oral diseases.

In the present invention, the oral diseases include, for example, but not limited to, oral malodor, which may be caused by oral microorganisms, periodontal diseases including dental caries, gingivitis and periodontitis, and oral mucosal ulcers. Concept.

In addition, the oral disease may include various oral diseases which may be caused by external physical stimulation as well as by oral microorganisms. For example, dental caries may be exposed due to tooth surface wear, Syphilis can also include symptoms.

As used herein, the term " treatment " in the present invention refers to an approach to obtaining beneficial or desired clinical results, which may or may not be able to detect beneficial or desired clinical results for the purposes of the present invention, Including, but not limited to, relieving symptoms, decreasing the severity of the disease, stabilizing (i.e., not becoming worse) conditions of the disease, delaying or slowing the progression of the disease, improving or temporarily alleviating and alleviating the disease state, But is not limited thereto. Thus, treatment refers to both therapeutic treatment and prophylactic measures, and those that need treatment include conditions that already have the disease, as well as conditions in which the disease is to be prevented. It may also refer to any action that may improve or improve the symptoms of oral diseases by administering the pharmaceutical composition of the present invention to a subject.

"Prevention" may refer to any act that inhibits or delays disease using the oral composition. The oral composition may be used in the form of a pharmaceutical composition, a food composition, or an oral care composition, but is not necessarily limited thereto.

As used herein, the term "improvement" means that the above symptom is reduced or relieved, and can be understood as a broad concept including mitigation, prevention, and treatment.

According to an embodiment of the present invention, the magnetically-designated extract of the present invention may be included in a composition for preventing, ameliorating or treating symptom, and the magnetically designated extract may exhibit the symptom prevention, improvement, or therapeutic effect of symptom.

As used herein, the term "syringe" refers to all phenomena, including, but not limited to, tooth decay or other pathological causes, or, separately, sharp, transient or persistent pain to external stimuli do. The external stimulus usually refers to a temperature stimulus, which is often accompanied by a cold temperature stimulus, which may cause pain at a hot temperature. In addition to such temperature stimuli, pain may also be caused by irritation, such as drying of teeth, contact with foreign substances, or osmotic pressure through sweet or new foods. It may appear entirely on the entire tooth and may be confined to specific areas such as the maxilla or mandible, right or left, dentine hyperesthesia, caries, or dental inflammation.

The cause of this symptom is considered to be the exposure of the mouth of the ivory tubule.

When the enamel or cementum is destroyed and the entrance of the dentinal tubule is exposed to the outside, the stimulation is transmitted to the dimension by the cell protrusion, nerve and dentin liquid of the dentinal tubule, and the pain can be felt.

The inventors of the present invention have found that the above magnetization designation extract can react with calcium ions contained in the needle to form a coating film on the tooth surface, and the formed coating film prevents exposure of the ivory tubule to prevent, Respectively.

The composition for preventing or treating oral diseases of the present invention can be directly applied to animals including humans. The animal is a biological group corresponding to a plant. It mainly consumes organic matter as nutrients, and has digestion or excretion and differentiation of the respiratory organs. Preferably, it may be a vertebrate, more preferably a mammal. Specifically, the mammal may be a human, a pig, a cow, or a goat. The composition for preventing or treating oral diseases may contain the magnetically designated extract alone as an active ingredient and may further contain additional components such as a pharmaceutically acceptable or nutritionally acceptable carrier, An excipient, a diluent or a subcomponent.

More particularly, the composition for preventing or treating oral diseases may further comprise, in addition to the active ingredient, a nutritional agent, a vitamin, an electrolyte, a flavoring agent, a colorant, a thickening agent, a pectic acid and a salt thereof, an alginic acid and a salt thereof, , a pH adjusting agent, a stabilizer, a preservative, a glycerin, an alcohol, and a carbonating agent used in a carbonated drink. The carrier, excipient or diluent may be selected from lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acicia gum, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methylcellulose, In the group consisting of celluloses, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil, dextrin, calcium carbonate, propylene glycol, liquid paraffin, But the present invention is not limited thereto. Any conventional carrier, excipient or diluent may be used.

The composition for preventing or treating oral diseases may further comprise conventional fillers, extenders, binders, disintegrants, surfactants, anti-coagulants, lubricants, wetting agents, flavoring agents, emulsifiers or preservatives, Or parenteral administration can be used.

Particularly, solid preparations for oral administration include tablets, pills, powders, granules, capsules and the like. These solid preparations may contain at least one excipient such as starch, calcium carbonate, Sucrose, lactose, gelatin and the like. In addition to simple excipients, lubricants such as magnesium stearate and talc may also be used. Examples of liquid formulations for oral use include suspensions, solutions, emulsions, syrups and the like. In addition to water and liquid paraffin which are commonly used simple diluents, various excipients such as wetting agents, sweeteners, fragrances, preservatives and the like may be included .

Examples of the form for parenteral administration include toothpastes, mouthwashes, topical administration agents (creams, ointments, dressing solutions, sprays, and other coating agents). An example of the formulations of the topical administration agent may be a composition for preventing or treating oral diseases, which contains an extract of designated magnetism as an active ingredient, impregnated with a carrier such as gauze made of natural fibers or synthetic fibers.

In the case of the cream or ointment, it may be suitable for direct application to periodontal disease, gingival disease, or cavities or their surroundings. In the case of the above-mentioned spray agent, it can be manufactured by a conventional spray agent manufacturing method except that it contains a magnetically-designated extract as an active ingredient. It can be packed in a compression vessel or other spray vessel and sprayed on the oral disease site from time to time, Prevention or treatment. In the case of the dressing solution, the dressing solution can be manufactured by a usual dressing solution manufacturing method except that it contains the magnetizing designated extract as an active ingredient. The dressing solution can be used for dressing on the oral disease site or dressing of other bacterial infection site, Can be prevented or treated.

In addition, the formulation of the composition for preventing or treating oral diseases according to the present invention may be in a desired form depending on the method of use, and may be formulated so as to provide rapid, sustained or delayed release of the active ingredient, The method can be adopted. Exemplary formulations include, but are not limited to, excipients, granules, lotions, liniments, rimonadense, powders, syrups, solutions, aerosols, EXTRACTS, elixirs, ointments, Suspensions, tablets, capsules, creams, pills, soft or hard gelatine capsules, and the like.

Furthermore, the compositions for the prevention or treatment of oral diseases of the present invention can be prepared by any of the known methods known in the art or by a method disclosed in Remington's Pharmaceutical Science (recent edition), Mack Publishing Company, Easton PA And the like.

The dosage of the composition for preventing or treating oral diseases according to the present invention can be suitably selected by those skilled in the art in consideration of the administration method, the age, sex and weight of the recipient, severity of the disease, and the like. For example, the composition for preventing or treating oral diseases according to the present invention may be administered at a dose of 0.0001 mg / kg to 1000 mg / kg, and more preferably at a dose of 0.01 mg / kg to 100 mg / kg. The administration may be carried out once a day or divided into several times. The dose is not intended to limit the scope of the invention in any way.

In addition, the composition for preventing or treating oral diseases according to the present invention may further comprise a compound having a known oral disease inhibitory activity or a plant extract, in addition to the magnetically designated extract, and the content may be varied depending on the preparation method and purpose of use .

In one embodiment of the present invention, there is also provided a food composition for preventing or ameliorating an oral disease, which comprises a magnetically-designated extract as an active ingredient. Examples of the food composition of the present invention include foods, food additives, beverages or beverage additives.

The food composition containing the magnetization designated extract as an active ingredient may further comprise suitable carriers, excipients and diluents conventionally used in the production thereof.

As used herein, the term " food " means a natural product or a processed product containing one or more nutrients. Preferably, it means that the food can be directly eaten through a certain degree of processing. It is intended to include food, food additives, health functional foods and beverages.

Foods to which the magnetism-designated extract of the present invention can be added include, for example, various foods, beverages, gums, candies, tea, vitamin complexes, and functional foods. In addition, in the present invention, the food may contain special nutritional foods (eg, crude oil, infant formula, etc.), meat products, fish products, tofu, mackerel, noodles (eg, (Such as soy sauce, soybean paste, hot pepper paste, mixed sauce), sauces, confectionery (eg snacks), dairy products (eg fermented milk, cheese), other processed foods, kimchi, pickled foods But are not limited to, natural flavors (eg, ramen soup, etc.), vitamin complexes, alcoholic beverages, alcoholic beverages and other health supplement foods. The food, beverage or food additive may be prepared by a conventional production method.

In the present invention, the functional food refers to a food group which is imparted with added value to function and express the function of the food by using physical, biochemical, biotechnological techniques and the like, the regulation of the biological defense rhythm of the food composition, The functional food of the present invention is preferably a food which is processed so that the body control function for preventing or ameliorating the oral disease can be sufficiently expressed in the living body It means food. The functional food may include a food-acceptable food-aid additive, and may further comprise suitable carriers, excipients and diluents conventionally used in the production of functional foods.

In the present invention, beverage is a generic term for drinking or enjoying a taste, and is intended to include functional beverages. The beverage is not limited to any particular ingredient except that the beverage contains the magnetically designated extract as an active ingredient as an essential ingredient at the indicated ratio and may contain various flavors or natural carbohydrates as an additional ingredient such as ordinary beverages . Examples of such natural carbohydrates include monosaccharides such as disaccharides such as glucose and fructose such as maltose, sucrose and the like and polysaccharides such as dextrins, cyclodextrins and the like, and Xylitol, sorbitol, and erythritol. Natural flavors (tau martin, stevia extract (e.g., rebaudioside A, glycyrrhizin, etc.) and synthetic flavors (saccharin, aspartame, etc.) can be advantageously used as flavors other than those described above The ratio of the natural carbohydrate is generally about 1 to 20 g, preferably 5 to 12 g, per 100 ml of the composition of the present invention. In addition, the composition of the present invention can be applied to natural fruit juice, fruit juice drink, May be further contained.

In addition to the above-mentioned composition, the composition of the present invention can be used as a flavoring agent such as various nutrients, vitamins, minerals (electrolytes), synthetic flavors and natural flavors, coloring agents and intermediates (cheese, chocolate etc.), pectic acid and its salts, Salts, organic acids, protective colloid thickeners, pH adjusting agents, stabilizers, preservatives, glycerin, alcohols, carbonating agents used in carbonated beverages and the like. These components can be used independently or in combination.

The functional beverage according to the present invention can be used to control the bio-defense rhythm of the beverage group or beverage composition to which the added value is imparted so that the function of the beverage acts on the specific purpose by physical, biochemical or biotechnological techniques, Means a beverage which has been designed so that the body control function related to restoration and the like is sufficiently expressed in the living body.

The functional beverage is not particularly limited to the other ingredients except that it contains the magnetization designated extract of the present invention as an essential ingredient at the indicated ratio, and may contain various flavors or natural carbohydrates as an additional ingredient such as ordinary beverages . Examples of such natural carbohydrates include monosaccharides such as disaccharides such as glucose and fructose such as maltose, sucrose and the like and polysaccharides such as dextrins, cyclodextrins and the like, and xylitol , Sorbitol, and erythritol. Natural flavors (tau martin, stevia extract (e.g., rebaudioside A, glycyrrhizin, etc.) and synthetic flavors (saccharin, aspartame, etc.) can be advantageously used as flavors other than those described above .

The present invention provides an oral hygiene composition for preventing or ameliorating an oral disease comprising an extract of designated magnetism as an active ingredient. The oral care composition of the present invention includes all kinds and formulations that can be used for oral hygiene. Non-limiting examples of the oral hygiene composition include toothpaste, mouthwash, oral spray, oral ointment, gum, and the like.

When the oral care composition of the present invention is a dentifrice, it may further comprise an abrasive, a dipping agent, a moisturizing agent, a foaming agent, a sweetener, a whitening agent or a flavoring agent, Examples of the abrasive include aluminum hydroxide, silicic anhydride, aluminum silicate, calcium hydroxide dibasic hydroxide and anhydrous calcium carbonate, calcium carbonate, calcium pyrophosphate, insoluble sodium metaphosphate, magnesium phosphate, magnesium carbonate, calcium sulfate, Polymethyl methacrylate, and the like can be used alone or in combination. The content of the abrasive may be generally 20% by weight to 90% by weight based on the total composition, but is not limited by the content.

When the oral care composition is a paste-like composition, the viscous solution may contain at least one of polyvinyl alcohol, sodium polyacrylate, polyacrylic acid / polyacrylic acid, polyvinyl alcohol, polyacrylic acid / Maleic acid copolymer and synthetic polymer derivatives such as carboxyvinyl polymer, and inorganic-based binders such as silica and laponite may be used singly or in combination. The content of the viscous agent may be generally from 0.3% by weight to 5% by weight based on the total composition, but is not limited by the content.

In addition, the oral hygiene composition may further contain sorbitol, glycerin, ethylene glycol, propylene glycol, polyether glycol, polypropylene glycol or the like as a moisturizing agent in its preparation.

In addition, the oral hygiene composition may further include a fragrance or a sweetener. The sweetener may be sucrose, lactose, maltose, sorbitol, xylitol, sodium cyclamate, glycerin, sodium saccharin, stevioside, aspartame, and the flavoring may be peppermint, menthol, anethole, The sweetener or fragrance may be used alone or in combination of two or more thereof. The sweetener or flavoring agent may be selected from the group consisting of alginic acid, citric acid, citric acid, limonene, citronellol, alpha terpineol, salicylmethyl, cineol, linarol, ethyl linolol, vanillin, thymol, spearmint oil, Or may be used in combination.

In addition, the oral hygiene composition of the present invention may contain a surfactant or an additional effective ingredient, which is used as a foaming component, alone or in combination. The surfactant used as the foaming component may be any one selected from the group consisting of an anionic surfactant, a nonionic surfactant and a cationic surfactant.

In the case where the oral care composition of the present invention is a dentifrice, it can be manufactured by a conventional method for producing a dentifrice, except that it contains a magnetically designated extract as an active ingredient. When the oral care composition of the present invention is a mouthwash solution, The preparation can be prepared by mixing the magnetically-designed extract with a solution and formulating it into a saline solution. Oral diseases can be prevented or treated by washing the mouth 2 to 10 times a day.

Further, when the oral care composition of the present invention is a tooth paste cream, it may further include a liquid containing water and a moisturizing agent, a gelling agent or a water-insoluble polish agent, a sweetener, a fragrance and the like.

In addition, when the oral care composition of the present invention is a mouthwash (cleaning agent), it may further comprise a toothpaste carrier, more specifically, a non-toxic alcohol.

The method for preparing a composition for treating or preventing an oral disease of the present invention can be produced according to a method conventionally prepared in the art for manufacturing the same.

In the present invention, the magnetization designation extract may be 0.001 to 10% by weight, preferably 0.005 to 5% by weight based on the total weight of the composition, more preferably 0.008 to 1% % ≪ / RTI > If the magnetization designation extract is less than 0.001% by weight based on the total weight of the composition, the effect on oral diseases may be insufficient. If the magnetization design extract is more than 10% by weight, the sensation of taste and the like may be poor.

example  The oral composition of the present invention may further contain, as components, a wetting agent, an abrasive, a pharmacological agent, a sweetening agent, a pH adjusting agent, a preservative, a binder, a flavoring agent, a foaming agent and the like in addition to the above- .

The wetting agent may be used alone or in combination of one or more selected from the group consisting of concentrated glycerin, glycerin, sorbitol aqueous solution, amorphous sorbitol aqueous solution, polyethylene glycols and propylene glycol. The amount of the wetting agent is 1 to 70 wt% based on the total weight of the oral composition.

The abrasive may be one selected from the group consisting of precipitated silica, silica gel, zirconium silicate, calcium monohydrogenphosphate, anhydrous calcium hydrogenphosphate, hydrated alumina, hard calcium carbonate, heavy calcium carbonate, calcium pyrophosphate, insoluble metaphosphate and aluminum silicate Etc. may be used. The amount of the abrasive to be used is generally 1 to 60% by weight based on the total weight of the oral composition. As a small amount of additives to be used, commonly used ingredients include sweeteners, pH adjusters, preservatives, coloring agents, and binders.

The active agent may be selected from the group consisting of sodium fluoride, sodium fluorophosphate, sodium fluoride, tin fluoride, chlorohexidine, allantoin chlorohydroxy aluminate, aminocaproic acid, zinc chloride, pyridoxine hydrochloride, tocopheryl acetate, Or more.

As the sweetening agent, saccharin, xylitol, erythritol, aspartame and the like can be used. The amount of the sweetener to be used is generally 0.05 to 2% by weight based on the total weight of the oral composition.

As the pH adjusting agent, sodium phosphate, disodium phosphate, citric acid, triethanolamine and the like can be used.

As the preservative, benzoic acid, methylparaben, propylparaben, sodium benzoate and the like can be used. As the fragrance, peppermint oil, spearmint oil, menthol and the like may be mixed and used. Other additives such as dextrinase may be used.

Carrageenan, xanthan gum, carboxymethylcellulose sodium, carboxyvinyl polymer, sodium alginate, and laponite may be used alone or in admixture of two or more.

As foaming agent, a copolymer of sodium lauryl sulfate, an anionic surfactant, polyoxyethylene polyoxypropylene (non-ionic surfactant), polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester and the like can be used .

Others may include residual water.

According to another embodiment of the present invention, there is provided an oral hygiene product comprising the composition. The composition for oral hygiene according to the present invention containing the magnetically-designated extract as an active ingredient is generally a composition for oral hygiene that can be included in all products manufactured and marketed for oral health, and there is no limitation on the oral hygiene product to be applied . For example, the oral care products include, but are not limited to, toothpastes, oral sprays, oral ointments, mouth patches, and mouthwashes. The oral care product of the present invention may be in the form of a liquid, a solid, a suspension, a gel, and an aerosol, but is not limited thereto.

The composition containing the magnetically labeled extract of the present invention provides a preventive, ameliorative or curative effect of the syringe.

The present invention provides a composition for oral use derived from natural materials, which has few side effects, is safe to human body, forms a fine film on the surface of teeth, and can prevent exposure of iv iv tubule.

It is possible to provide a composition which is excellent in stability without showing toxicity while exhibiting prevention or improvement of excellent silane.

Hereinafter, the present invention will be described in more detail with reference to the following examples. However, the embodiments according to the present invention can be modified into various other forms, and the scope of the present invention should not be construed as being limited to the embodiments described below. The embodiments of the present invention are provided by way of example to facilitate a specific understanding of the present invention.

≪ Preparation of extract designated with magnetization >

The magnetization designation extract of the present invention was prepared by the following method.

The magnetization designation was cut off and immersed in a 95% ethanol solution, and extracted at room temperature for 48 hours to obtain a designated magnetized extract.

<Experiment 1> Comparing the degree of suppression of silent phenomenon>

In order to compare the degree of suppression of the syringes, there can be mentioned, first, carboxymethylcellulose sodium, sodium laurylsulfate, glycerin, colloidal silicon dioxide, silicas, sodium cocoyl sulfate, sodium cocoate, Control dentifrice was made using Dodicin, sweetener, aromatic, coloring agent and the like, and an experimental dentifrice containing 0.01 wt% of the designated extract of magnetization was prepared.

The degree of suppression of the syringes of the compositions prepared above was compared and measured. In other words, the study subjects were 40 volunteers who agreed to participate in this experiment. Among the applicants, 20 were male and 20 were female, and the ages ranged from 20 to 50 years. The study subjects were not informed about the contents of the toothpaste, and the total test period was 2 weeks.

After the temperature stimulus was applied, the test was performed by measuring the response of the patient. Prior to the test, the hypersensitive areas of the hypersensitive teeth of each volunteer were checked in advance, and cold water of about 5 ° C was dropped on the acupressure of the teeth and dropped on a syringe. After the evaluation, each composition was used three times a day for 2 weeks After 2 weeks, cold water of about 5 ° C was dropped into the eyedropper. After the stimulation, the patient's response rating criteria were set as follows (0 points: no discomfort, 1 point: slightly uncomfortable, 3 points: sick). Statistical analysis was done by paired student-t test before and 2 weeks after the experiment.

Table 2 shows the response scores to the temperature stimulation after 2 weeks.

Degree of inhibition

group
time Control group Experimental group 0 weeks 2.12 0.41 2.13 + - 0.14 2 weeks 2.13 + 0.02 1.58 ± 0.23 p > 0.05 * p < 0.05

As can be seen in Table 1 above, the response to temperature stimulation was much less in the experimental group administered the Magnetized Design Extract. This indicates that the inhibitory effect of acylation was excellent in the group administered with the designated extract of Magnetium. The components contained in the Magnetized Design Extract of the present invention meet the calcium component contained in the saliva and form a coating film on the teeth surface, It was able to alleviate the hypersensitivity symptoms.

[meaning]

It has been confirmed that the magnetized design extract improves the sensitivity to temperature stimulation. This resulted in the mitigation of the silence.

It is believed that the magnetically-designed extract of the present invention has a definite effect as a natural material which is contained in the oral composition and effectively maintains and improves the oral magnetization designation.

Claims (11)

An oral hygiene composition for preventing or ameliorating an oral disease comprising an extract designated as an effective ingredient. The method of claim 1, wherein the magnetization designation extract is selected from the group consisting of water, distilled water, methanol, ethanol, propanol, isopropanol, butanol, acetone, ether, benzene, chloroform, ethyl acetate, methylene chloride, n-hexane, Wherein the composition is extracted with at least one solvent selected from the group consisting of ethyl ether and cyclohexane. The oral care composition according to claim 1, wherein the magnetically-designated extract is extracted with water, ethanol, or a mixture thereof. The oral care composition according to claim 1, wherein the magnetically-designated extract is contained in an amount of 0.001 to 10% by weight based on the total weight of the oral care composition. The oral care composition according to claim 1, wherein the oral disease is psoriasis. [Claim 3] The oral care composition of claim 1, wherein the magnetically-designated extract forms a coating film on the surface of the teeth to relieve or ameliorate the symptoms. The oral care composition according to claim 1, wherein the oral care composition has one or more formulations selected from the group consisting of a toothpaste, a mouthwash, an oral spray, an oral ointment, a mouth patch, and a gum. A food composition for preventing or ameliorating an oral disease comprising an extract designated as an effective ingredient. The food composition according to claim 8, wherein the oral disease is psoriasis. A pharmaceutical composition for preventing, ameliorating, or treating an oral disease comprising an extract of designated magnetism as an active ingredient. [Claim 11] The pharmaceutical composition according to claim 10, wherein the oral disease is psoriasis.