KR20180014355A - Anti-dust Cosmetic composition with Temperature-sensitive polymer - Google Patents

Abstract

The present invention relates to a cosmetic composition for preventing fine dust adsorption. More specifically, the present invention relates to a cosmetic composition which forms a coating film on a skin surface by containing a temperature-sensitive polymer as an active ingredient, and prevents skin contact or infiltration of fine dust, containing contaminants such as exhaust gas from vehicles and exhaust from plants, into skin. In addition, the cosmetic composition can be easily washed off with tepid water, and the coating film easily removes fine dust remaining on the skin while washed off.

Description

[0001] The present invention relates to a cosmetic composition for preventing fine dust adsorption by a thermosensitive polymer,

The present invention relates to a cosmetic composition for preventing fine dust adsorption, and more particularly, to a cosmetic composition for preventing fine dust adsorption, which comprises a temperature sensitive polymer as an active ingredient to form a film on the skin surface, The present invention relates to a cosmetic composition which can prevent contact or penetration into the skin, easily wash with lukewarm water, and can easily remove fine dust remaining on the skin during the wash-off process.

Dust floating in the air is classified into total dust, fine dust with a diameter of 10 μm or less (PM ₁₀ ), and ultrafine dust with a diameter of 2.5 μm or less (PM _2.5 ), depending on the particle size. Fine dust is mainly emitted from automobile exhaust gas and factory chimneys, and it is blown in the case of China's yellow dust or severe smog, and it becomes an issue every spring. Fine dust is nitrate (NO ^3-), ammonium (NH ^4+), sulfate (SO ₄ ^2-) and consists of an ion component and a carbon compound, a metal compound such as, immune system is dramatically reduced when exposed to long-term particulate matter It can be exposed to various diseases such as cardiovascular diseases, skin diseases, eye diseases as well as respiratory diseases such as cold, asthma and bronchitis. Particularly, the ultrafine dust generated in the combustion of cigarette smoke or fuel causes a variety of diseases because it is easy to infiltrate into the bronchus and the deep lung of the human body because the particle size is small.

It causes various diseases composed of nitrate, sulphate and organic carbon which are secondary pollutants produced through various reactions in the atmosphere. During acute exposure, airway stimulation causes coughing and dyspnea, and asthma worsens and arrhythmia occurs. Chronic exposure can reduce pulmonary function, increase chronic bronchitis and increase mortality. In particular, patients with heart or lung disease, children, the elderly, and pregnant women are more likely to be affected by exposure to fine dust, and even adults may have these symptoms temporarily when exposed to high concentrations. In addition, fine dust can cause various diseases by touching the body itself. Since the size of fine dust is as small as about one-twentieth of the skin pore, it can not be blocked from the skin and it is easy to penetrate into the pores and it is difficult to remove it, causing chemical stimulation to the skin, adversely affecting keratinocyte and lipid membrane, It causes acne, atopic and other dermatitis.

In order to prevent skin troubles caused by such fine dust, there is a method of washing the fine dust by cleansing or applying a skin protecting cosmetic to prevent fine dust from touching the skin. Conventionally, most of the fine dust-related cosmetics are cleansing products that use minute bubbles to clean fine dust and various contaminants including make-up residue. Fine dust that has penetrated into the skin can be partially removed by cleansing, but it is impossible to remove it completely. Therefore, it is necessary to protect the skin in such a way as to prevent the fine dust from coming into contact with or adsorbing on the skin to reduce the penetration of fine dust.

As a prior art, Korean Patent Laid-Open Publication No. 10-2010-0056239 (published on May 28, 2010, entitled "Cosmetic Composition for Heavy Metals and Fine Dust Adsorbing Containing Polysaccharides") was disclosed, But rather promotes the adsorption of fine dust. Therefore, there is a fear of causing skin trouble when it is included in cosmetics.

The inventors of the present invention have conducted intensive researches to overcome the problems of the prior art. As a result, the inventors of the present invention have found that the thermosensitive polymer maintains a sol state in a liquid state at room temperature or below, The inventors of the present invention have found that it is possible to easily remove fine dust as well as skin adsorption when a cosmetic composition capable of easily washing with lukewarm water is formed while forming a film in a gel state on the surface of the skin.

KR 10-2010-0056239 A

Accordingly, a main object of the present invention is to provide a cosmetic composition containing a thermosensitive polymer component capable of forming a thin film on the skin and easily removable with lukewarm water when the cosmetic is applied to prevent skin penetration and adsorption of fine dust I have to.

In addition, the cosmetic composition for preventing the fine dust adsorption prevents the skin irritation caused by external contaminants and facilitates skin cleansing, thereby reducing skin inflammation and troubles caused by fine dust, thereby preventing skin damage.

According to one aspect of the present invention, there is provided a cosmetic composition for preventing fine particle adsorption, which comprises a thermosensitive polymer as an active ingredient in a cosmetic composition. The cosmetic composition of the present invention is characterized by including a thermosensitive polymer as an active ingredient for blocking fine dust adsorption in addition to general cosmetic compositions such as water, oil and surfactant.

In the present invention, the fine dust refers to very small particles having a diameter of several tens of micrometers or less which float in the air and can affect the skin. For example, dust having a diameter of 10 μm or less is used for dust, automobile, exhaust gas, Ambient air pollutants such as combustion gases and heavy metals.

In the present invention, the temperature responsive polymer is maintained in a sol state at about room temperature (20 to 25 ° C), but has a property of changing to a gel state at a skin surface temperature (30 to 40 ° C) By weight based on the total weight of the cosmetic composition. The cosmetic composition prepared using the thermosensitive polymer forms a thin gelatinous film when applied to the surface of the skin to prevent the fine dust from being absorbed or penetrated into the skin, The fine dust remaining on the skin can be easily detached.

In the present invention, representative polymers having such temperature sensitivity characteristics include Pluronic (P. Holmqvist et al . , Int . J. Pharm . , 194, 103, 2000), PNIPAAm (M. Harmon ..., etc., Macromolecules, 36, 1, 2003 ), hyaluronic acid (HA) (such as M. Ogiso, J. Biomed Mater Res, 39, 3, 1998), a linear polyethylene glycol (PEG) - polylactic acid / glycolic acid copolymer (PEG) -Polylacetic acid (PLA) -Polyethylene glycol (PEG) -Polyethylene glycol (PEG) (B. Jeong et al . , J. Biomed . Mater. Res. , 50, , Star polyol (PLA) -polyethylene glycol (PEG), star poly-epsilon -caprolactone (PCL) -polyethylene glycol (PEG) (S. Zhao et al . , J. Func . Polym . , 15, 1, 2002) . Of these, F-127 and F-68 among hyaluronic acid and pluronic were approved as possible substances by the US Food and Drug Administration (FDA).

In the present invention, the thermosensible polymer used is Pluronic F-127 represented by the following structural formula (1). Pluronic F-127 is a copolymer (molecular weight: 12,600) consisting of polyethylene oxide (PEO) -polypropylene oxide (PPO) -polyethylene oxide (PEO), a composition ratio of PEO: PPO: PEO of 98:68:98, It is non-toxic and transitions occur between a gel state with no fluidity and a sol state with fluidity in the temperature range close to body temperature (33-37 ° C). Therefore, it is possible to increase the effect of preventing the skin contact and adsorption and penetration of fine dust in the composition of the present invention.

[Structural formula 1]

In the present invention, since a gel made of a pluronic polymer is a physical gel, its mechanical properties are so weak that its shape may be collapsed due to external temperature and force. Therefore, it is preferable to form a double bond at both ends of the pluronic polymer Acrylate is added thereto to synthesize diacrylated pluronic and then chemically cross-linked hydrogel is formed by using ultraviolet rays (UV) to be used in cosmetics (Korean Patent Laid-Open No. 10-2014-0006172 ).

In the present invention, the thermosensible polymer preferably comprises 0.1 to 30% by weight, more preferably 1 to 20% by weight, of the total amount of the cosmetic composition. If the content is less than the above range, the effect of blocking fine dust adsorption may be deteriorated, and if it exceeds the content range, it may affect the properties of the formulation and feeling of use.

In the present invention, the cosmetic composition of the present invention has a formulation of O / W (water to oil) to W / O (oil-in-water) emulsion. The O / W (water-in-oil) to W / O (oil-in-water) emulsion formulations can be prepared according to methods known in the art by mixing water and oily components used in the emulsion preparation of common cosmetics. The cosmetic composition of the present invention may have a general formulation of a cosmetic such as a lotion, a skin lotion, or an essence.

In the example of the present invention, an emulsified formulation was prepared so that the aqueous base (A) and the aqueous phase (B) were divided into a cosmetic base so that the top of the water contained Pluronic F-127 serving as a thermosensitive polymer.

According to one aspect of the present invention, the present invention provides a process for preparing a composition for preventing fine dust adsorption comprising the steps of:

a) mixing the oily phase (A) and dissolving at a temperature of 70 to 80 DEG C by heating;

b) dispersing and dissolving the polyol and the thermosensitive polymer component in water to prepare an aqueous phase (B);

c) adding the oily phase (A) to the aqueous phase (B) at a temperature of 70 to 80 占 폚 and stirring with a homomixer;

d) mixing the thickening agent (C) with the mixed solution of c), then adding the preservative (D) and stirring with a homomixer; And

e) cooling the reaction product to 30 캜 after the stirring, and then removing bubbles.

The cosmetic composition of the present invention may contain, in addition to the skin friction reducing substance for preventing fine dust adsorption, the ingredients to be incorporated in ordinary cosmetics such as oils, hydrocarbons, lead, fatty acids, synthetic esters, alcohols, powders, surfactants, A thickener, a polymer compound, a gelling agent, an ultraviolet absorber, an ultraviolet scattering agent, an antioxidant, a coloring matter, a pigment, a preservative, a fragrance, a medicament or water may be appropriately selected and used within the range not impairing the effect of the present invention.

Examples of the oils and fats include jojoba oil, castor oil, olive oil, soybean oil, palm oil, palm oil, cacao oil, mink oil and turtle oil.

Examples of hydrocarbons include liquid paraffin, petrolatum, microcrystalline wax, and squalane.

As the lead, wax, lanolin, carnauba wax, candelilla wax and the like can be mentioned.

Examples of the fatty acid include myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid and lauric acid.

Examples of synthetic esters include myristic acid esters such as isopropyl myristate, isopropyl palmitate, butyl oleate, myristyl myristate, octyldodecyl myristate, propylene glycol monostearate, myristyl lactate, isostearyl malate, glyceryl monostearate, Dimethyldimethylammonium, and the like.

The oils, hydrocarbons, lead, fatty acids, and synthetic esters can be blended in a ratio of 0 to 30 w / w% per skin cosmetic composition.

Examples of the alcohols include ethanol, 1,3-butylene glycol, propylene glycol, lauryl alcohol, cetanol, stearyl alcohol, and oleyl alcohol. Alcohols can usually be formulated at a ratio of 0 to 25 w / w% per skin cosmetic composition.

Examples of the surfactant include polyglycerin fatty acid esters, sorbitan fatty acid esters, polyoxyethylene fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene alkyl ethers, coconut fatty acid monoethanolamide, polyoxyethylene hydrogenated castor oil N-octadecyltrimethylammonium chloride, monoalkyl (meth) acrylate, sodium laurylsulfate, polyoxyethylene glyceryl isostearate pyroglutamate, sodium alkylbenzenesulfonate, polyoxyethylene stearyl ether, dialkylsulfosuccinic acid, cetylpyridinium bromide, N-acyl glutamine, sucrose fatty acid ester, polyoxyethylene sorbitan monostearate, polyoxyethylene lauryl ether sodium sulfate, polyoxyethylene reduced lanolin, sugar ester, and the like can be given. Surfactants may be formulated at a ratio of 0 to 10 w / w% per skin cosmetic composition.

Examples of the thickening agent include carboxyvinyl polymer, methylpolysiloxane, dextran, carboxymethylcellulose, carrageenan, and hydroxypropylmethylcellulose. The thickening agent may be formulated usually at a ratio of 0 to 5 w / w% per skin cosmetic composition.

Examples of the moisturizing agent include glycerin, propylene glycol, 1,3-butylene glycol, pyroglutamic acid, acetylglutamic acid, and procyanidins. The moisturizing agent can usually be formulated at a ratio of 0 to 25% per skin cosmetic composition.

Examples of the preservative include benzoic acid, salicylic acid, dihydroacetic acid or salts thereof, phenols of paraoxybenzoic acid esters, and triclosan halocarbons. The preservative may be formulated at a ratio of 0 to 0.3 w / w% per skin cosmetic composition.

Any fragrance may be used as long as it is usually used in cosmetics.

Examples of pigments include iron oxide, titanium dioxide, zinc oxide, kaolin, and talc. The pigments may be formulated at a ratio of 0 to 5 w / w% per skin cosmetic composition.

Examples of the drug include wheat germ oil, vitamin A, vitamin B2, vitamin E, magnesium ascorbate-2-phosphate or sodium salt, D-pantothenyl alcohol, glycyrrhizinate dipotassium, glutathione, , Chelating agents, food extracts, microbial metabolites / extracts, and the like. Agents can usually be formulated at a rate of 0 to 5 w / w% per skin cosmetic ingredient.

Examples of the water include tap water, mineral water, salt water, seawater, deep sea water, ultrapure water, polar ice water, mineral-containing water and purified water. Water is blended at an arbitrary ratio.

According to the present invention, it is possible to prevent skin contact of fine dust containing contaminants such as soot and automobile exhaust gas from a factory by providing a cosmetic composition for preventing fine dust adsorption which contains a thermosensitive polymer as an active ingredient. In addition, the cosmetic composition according to the present invention prevents the occurrence of skin irritation caused by skin adsorption of fine dusts, thereby preventing the occurrence of skin troubles and thus protecting the skin.

FIG. 1 is a graph showing the experimental results of the fine dust desorption effect of Examples and Comparative Examples of the present invention. FIG.

Hereinafter, the present invention will be described in more detail with reference to Examples. These embodiments are only for illustrating the present invention, and the scope of the present invention is not construed as being limited by these embodiments.

Example 1: Preparation of Comparative Examples and Examples

The cosmetic compositions of Comparative Example 1 and Examples 1 to 3 having the composition (unit: wt%) as shown in Table 1 below were prepared. The comparative example is a cosmetic composition of a formulation not containing a temperature sensitive polymer component, and the embodiment is a cosmetic composition according to the content of a temperature sensitive polymer component. Concretely, the A phase (oily phase) is dissolved by heating at 70 to 80 ° C, and then slowly added to the B phase (aqueous phase) at room temperature. At this time, the mixture of A phase and B phase is constantly stirred, and then C part (thickener) is added and stirred. Thereafter, the mixture was cooled to 40 캜, and D part (preservative) was added thereto, followed by cooling to prepare respective formulations. In Table 1, PEG-100 (PEG-100 stearate, PEG-100 stearate) is a nonionic surfactant, DPG (dipropylenglycol, dipropylene glycol) is a polyol used as a solvent to dissolve intercellular components, and 1.3 -BG (1.3-Butylene Glycol, 1.3-butylene glycol) is a polyol for achieving a moisturizing effect, and Plunonic F-127 is a temperature-sensitive polymer.

Comparative Example  One Example  One Example  2 Example  3 A Cetearyl alcohol 2 2 2 2 PEG-100 0.5 0.5 0.5 0.5 DPG 10 10 10 10 B Purified water Suitable amount Suitable amount Suitable amount Suitable amount Pluronic F-127 - One 3 5 1.3-BG 5 5 5 5 C Incrementer Suitable amount Suitable amount Suitable amount Suitable amount D antiseptic Suitable amount Suitable amount Suitable amount Suitable amount

Experimental Example  1: Fine dust removal effect

The microdirt desorption effect for the formulations containing the thermosensitive polymer, Pluronic F-127, and the comparative example was performed. Carbon black (average particle size: 8.31 mu m) having a size similar to fine dust was used as a fine dust substitute material. The fine dust detachment effect was evaluated by visual inspection by a panel of 10 experts after thoroughly spraying the fine dust on the skin evenly applied in the comparative examples and the examples and then washing with lukewarm water (about 25 ° C). The evaluation method means that the higher the degree of desorption of the carbon black sprayed on the basis of the scale of 10 points, the higher the score and the more effectively the fine dust is desorbed to prevent the adsorption of the fine dust on the skin.

Experiment Item Comparative Example  One Example  One Example  2 Example  3 Panel Evaluation
Mean (n = 10) 3.6 4.5 6.7 9.1

As can be seen from the above Table 2, it can be seen that the higher the content of the thermotropic polymer, Pluronic F-127, is, the greater the degree of fine dust desorption. It was concluded that the higher the content of the thermosensitive polymer, the better the film formation on the surface of the skin and the greater the effect of preventing the adsorption of fine dust on the skin by washing well in water in response to the lukewarm water.

Experimental Example  2: skin safety test

20 adult subjects without skin disease were evaluated for the degree of stimulation of each formulation prepared in Comparative Example 1 and Example 3 in which the fine dust desorption effect was the highest, as follows. After 20 μL of the sample was applied to all of the arms of the testees, the test site was closed, and the information was spiked for 24 hours. After 30 minutes and 24 hours after the spy was removed, the skin reaction was checked according to the terminology shown in the CTFA guidelines do. The criteria are as follows. The average score of the test takers obtained by the criterion was less than 1, low stimulus. If less than 3, it is judged as a light stimulus. If it is less than 5, it is a medium stimulus. If it is 5 or more, it is regarded as a strong stimulus.

Experiment Item Comparative Example  One Example  3 Skin irritation index (PII) 0.31 0.33

As described above, in each of Comparative Example 1 and Example 3, skin irritation was less than 1, and it was confirmed that the irritation level was low enough to be used in the product.

The cosmetic composition containing the thermosensitive polymeric pluronic F-127 of the present invention forms a film on the surface of the skin to prevent direct contact of the fine dust with the skin and is a water-soluble substance which reacts with temperature. Therefore, Thereby reducing skin adsorption of fine dust.

Claims (6)

A cosmetic composition for preventing fine dust adsorption, which comprises a thermosensitive polymer as an active ingredient in a cosmetic composition.
The cosmetic composition for preventing fine dust adsorption according to claim 1, wherein the temperature responsive polymer is maintained in a sol state at a room temperature but changes in a gel state at a skin surface temperature.
The method of claim 1, wherein the thermosensitive polymer is selected from the group consisting of Pluronic, PNIPAAm, HA, linear polyethylene glycol (PEG) -Polyactic acid / glycolic acid copolymer (PLGA) -polyethylene glycol PEG), linear polyethylene glycols (PEG) -poly lactic acid (PLA) -polyethylene glycol (PEG), star polylactic acid (PLA) -polyethylene glycol (PEG), and star poly-epsilon -caprolactone (PCL) -polyethylene glycol PEG). ≪ / RTI >
The thermosensible polymer according to claim 1, wherein the thermosensitive polymer has a coating on the surface of the skin to prevent fine dust from being absorbed or penetrated into the skin, and is capable of cleansing with lukewarm water to easily detach residual fine dust A cosmetic composition for preventing fine dust adsorption.
The cosmetic composition for preventing fine dust adsorption according to claim 1, wherein the thermosensitive polymer is contained in an amount of 1 to 20% by weight.
The cosmetic composition for preventing fine dust adsorption according to claim 1, wherein the cosmetic composition has an O / W (water content) to W / O (oil-in-water) emulsion formulation.

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