KR20180011058A - A saliva secretion promoting agent, an oral dry inhibitor and an oral water-giving agent, and a composition - Google Patents

Abstract

A saliva secretion promoter comprising polyglutamic acid and / or a salt thereof and Aspalathus linearis extract as an active ingredient.

Description

A saliva secretion promoting agent, an oral dry inhibitor and an oral water-giving agent, and a composition

The present invention relates to a saliva secretion promoting agent, an oral dry inhibitor and an oral cavity water-giving agent, and a composition.

In dry mice, the amount of saliva secretion is lowered, causing abnormalities in the quality of saliva, resulting in dry throat, dry mouth, pain and discomfort. And it is accompanied by sticky discomfort, difficulty of conversation, and occurrence of bad breath. In addition, when pathological, the oral cavity functions, as well as the dysfunction of the whole body health, are caused from changes of oral microflora (dental flora), caries, periodontal diseases and various infectious diseases.

As the symptom therapy, moisturizing in the oral cavity with artificial saliva, oral moisturizer and wetting agent can be mentioned, but it is not a fundamental solution. Therefore, accelerating saliva secretion and shrinking the oral cavity is important in keeping the oral cavity fresh and preventing oral diseases and systemic diseases. As the saliva secretion promoting agent, there may be mentioned polyglutamic acid and salts thereof, but a technique having a more excellent saliva secretion promoting effect is desired.

Patent Document 1: Japanese Patent Application No. 2010-520913 Patent Document 2: Japanese Patent Application Laid-Open No. 2008-24620 Patent Document 3: Japanese Patent Application Laid-Open No. 2006-117563 Patent Document 4: Japanese Patent Application Laid-Open No. 2000-239136 Patent Document 5: International Publication No. 2005/049050

SUMMARY OF THE INVENTION The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a saliva secretion promoting agent, an oral dry inhibitor, an oral water-holding agent, and an oral and an eveningwear composition which are effective for improving dry mice.

DISCLOSURE OF THE INVENTION As a result of intensive studies to achieve the above object, the present inventors have found that by using polyglutamic acid and / or its salt and Aspalathus linearis extract together, saliva secretion is promoted, It has been found that the sticky discomfort is eliminated, thereby leading to the invention.

Accordingly, the present invention provides the following agents and compositions.

[One].

A saliva secretion promoter comprising (A) a polyglutamic acid and / or a salt thereof, and (B) an extract of Aspalathus linearis as an active ingredient.

[2].

An oral dry inhibitor comprising (A) polyglutamic acid and / or its salt and (B) Aspalathus linearis extract as an active ingredient.

[3].

Orally active ingredient, (A) a polyglutamic acid and / or a salt thereof, and (B) an extract of Aspalathus linearis as an active ingredient.

[4].

(A) polyglutamic acid and / or salt thereof, and (B) Aspalathus linearis extract.

[5].

A composition for promoting saliva secretion promotion or an oral composition for promoting saliva secretion comprising (A) polyglutamic acid and / or salt thereof and (B) Aspalathus linearis extract as an active ingredient.

[6].

The composition for oral dry inhibition or the composition for oral dry inhibition, which contains (A) polyglutamic acid and / or salt thereof and (B) Aspalathus linearis extract as an active ingredient.

[7].

An oral composition for imparting an intraoral oral water or an undergarment composition for imparting an intraoral oral water containing (A) a polyglutamic acid and / or a salt thereof and (B) an extract of Aspalathus linearis as an active ingredient.

[8].

(4) to (7), wherein the content of (A) polyglutamic acid and / or its salt is 0.001 to 50 mass% and (B) the content of Aspalathus linearis extract is 0.0001 to 80 mass% Or a salt thereof.

Fig. 1 is a graph showing the saliva secretion promoting action of polyglutamic acid and / or salt thereof and Aspalathus linearis extract. Fig.
Fig. 2 is a graph showing the effect of inhibiting oral dryness of the polyglutamic acid and / or salt thereof and the extract of Aspalathus linearis and the water-holding effect in the oral cavity.

Hereinafter, the present invention will be described in detail.

The present invention relates to a composition for oral administration comprising (A) a polyglutamic acid and / or a salt thereof, (B) an extract of Aspalathus linearis as an active ingredient, a saliva secretion promoter, an oral dry inhibitor, to provide.

[(A) polyglutamic acid and / or its salt]

As polyglutamic acid, α or γ-polyglutamic acid which is chemically synthesized, or natural α or γ-polyglutamic acid obtained as a fermentation product from various strains, and salts thereof can be used. In this case, natural polyglutamic acid is preferred because it is incorporated into oral compositions and foods, and γ-polyglutamic acid which can be mass-produced industrially is most suitable. Polyglutamic acid may be D-type or L-type. Polyglutamic acid is insoluble in water, but it becomes water-soluble when it is a salt. Examples of the salt include sodium salt, potassium salt, magnesium salt, calcium salt, ammonium salt, ethanolamine salt, basic amino acid salt and the like, but sodium or potassium salt is preferable. The degree of neutralization of the salt used in the present invention can be arbitrarily selected in accordance with the purpose in the range of pH 1 to pH 14 in the aqueous solution having the concentration of 1% by mass.

The viscosity of the polyglutamic acid or its salt is not particularly limited and various viscosity may be used depending on the kind of the product. The viscosity of the 4 mass% aqueous solution measured by a method described later is preferably 10 to 200 mPa · s, And more preferably in the range of 30 to 120 mPa · s.

<Viscosity Measurement Method>

96 g of water is taken in a 200 ml beaker, and 4.0 g of polyglutamic acid or its salt is added thereto while stirring with a steerer. Next, after standing for 1 hour in a constant-temperature water bath at 25 ° C, the viscosity is measured accurately after one minute using the following BL-type viscometer.

BL type viscometer: Tokyo meter: B type viscometer, type: BL, rotor: No. 2, revolution speed: 60 rpm, measurement temperature: 25 DEG C

As the polyglutamic acid or a salt thereof, a commercially available product can be used, and for example, Meiji-polyglutamic acid and the like made by Meiji-hodemateri Co., Ltd. can be used as sodium γ-polyglutamate.

[(B) Aspalathus linearis extract]

Aspalathus linearis is also referred to as rooibos (hereinafter abbreviated as "rooibos") and belongs to the genus Aspalathus (Fabaceae). The rooibos extract can be easily obtained by a method generally used for extracting plants, and the extraction method is not particularly limited as long as the effect of the present invention can be obtained. In addition, commercially available rooibos tea extract powder can be used.

The extraction site of rooibos is not particularly limited and can be selected appropriately. For example, there are leaf parts, young leaf parts, branch parts, stem part, bark part, flower part, fruit part, root parts, . Of these, new-leaf portions and branch portions are preferable.

The rooibos used for the extraction may be fermented or non-fermented. Fermentation means production through an oxidation (oxidation) process, and non-fermentation refers to the oxidation process, that is, not through fermentation. The oxidation process of the fermentation is not particularly limited, and a commonly used method can be used. For example, it refers to an oxidizing process in which a function (water content) is made and incubated at 20 to 40 ° C, or an oxidizing process under daylight (sunlight).

The rooibos extract may be obtained by a pulverization treatment using a pulverizing machine (roughening machine), or a drying treatment, or a combination thereof, followed by solvent extraction as described below. The drying treatment is not particularly limited, and a commonly used method can be used. For example, it is preferably carried out at 60 DEG C or lower.

The extraction method is not particularly limited and can be appropriately selected. For example, an extract can be obtained by introducing an extraction site of roubus as an extraction raw material into a treatment tank filled with an extraction solvent, eluting a soluble component while appropriately stirring according to necessity, and then removing the extraction residue by filtration.

The extraction solvent is not particularly limited and can be appropriately selected. For example, water (water), a hydrophilic solvent, a hydrophobic solvent, or a mixed solvent thereof. Examples of the water include pure water, tap water, well water, mineral water, mineral water, hot spring water, spring water, fresh water, purified water, hot water, ion exchange water, physiological saline, Buffered physiological saline, and the like. Examples of the hydrophilic solvent include lower alcohols having 1 to 6 carbon atoms such as methanol, ethanol, propyl alcohol and isopropyl alcohol; Lower aliphatic ketones such as acetone and methyl ethyl ketone; And polyhydric alcohols having 2 to 6 carbon atoms such as 1,3-butylene glycol, propylene glycol and glycerin. Examples of the hydrophobic solvent include aromatic carbon such as benzene and toluene; Organic solvents such as ethyl acetate, acetonitrile and ether; And halogenated carbons such as dichloromethane and chloroform. The mixed solvent is not particularly limited, and the water, the hydrophilic solvent and the like may be appropriately mixed and used. The ratio of the mixed solvent is preferably 1 to 90 parts by mass, respectively, of a lower alcohol, a lower aliphatic ketone, a polyhydric alcohol, etc. with respect to 10 parts by mass of water. The extraction solvent is preferably water, ethanol, or a mixture of water and ethanol, more preferably 0 to 20 mass% ethanol aqueous solution, and more preferably water.

The amount of the extraction solvent to be used is not particularly limited and can be appropriately selected depending on the extraction solvent, extraction method and the like. For example, 1 to 1,000 parts by mass of the extraction solvent may be used for 1 part by mass of the extraction site.

The extraction conditions (extraction time and extraction temperature) are not particularly limited and can be appropriately selected in accordance with an extraction method such as an extraction solvent. When the solvent is water, the extraction temperature is preferably room temperature to hot water, and more preferably hot water.

The rooibos extract may be purified and used according to need, and the purification method is not particularly limited and may be appropriately selected. For example, purification methods such as liquid-liquid partitioning extraction, various chromatography, membrane separation, supercritical fluid extraction and the like can be mentioned.

Specific examples of the rooibos extract include, but are not limited to, the extract itself, a dried product of the extract, a diluted solution of the extract, a dried product of the diluted solution of the extract, a concentrate (concentrated extract) of the extract, , A powder of a dried material, or the like can be used. As the extract, a water (water) extract is preferable, and a hot water extract is particularly preferable.

As the rooibos extract, for example, a commercially available rooibos tea extract may be used. Examples of commercially available rooibos tea extract include powders obtained by filtering a hot-water extract of fermented young leaves of rooibos and concentrating and drying the filtrate.

[Saliva secretion promoter]

By the combination of the polyglutamic acid and / or its salt and the (B) roubus extract, the remarkable saliva secretion promoting effect which can not be obtained alone can be obtained. The present invention provides a saliva secretion promoting agent containing this as an effective ingredient.

[Oral dry inhibitor]

By the combination of the polyglutamic acid and / or its salt and the (B) roubus extract, the remarkable saliva secretion promoting effect which can not be obtained alone can be obtained and the effect of suppressing drying in the mouth is obtained . The present invention provides an oral dry inhibitor containing this as an active ingredient.

[Oral Dampening Agent]

By the combination of (A) polyglutamic acid and / or its salt and (B) rooibos extract, remarkable saliva secretion promoting effect which can not be obtained alone can be obtained, and a water-holding effect in the oral cavity can be obtained. The present invention provides an intraoral oral moisturizing agent containing this as an active ingredient.

The amount of the polyglutamic acid and / or its salt and the amount of the (B) rooibos extract to be added to each agent is appropriately selected according to the form of the composition, the mode of administration (administration), and the subject of administration (administration). The effective amount for achieving the desired effect of each agent such as saliva secretion promotion is as follows, and is appropriately selected from the state and age of the subject to be administered (administered).

The effective amount of (A) polyglutamic acid and / or its salt is preferably 0.01 to 5,000 mg / day, more preferably 0.05 to 1,000 mg / day, per day for an adult, more preferably 0.1 to 500 mg / day is more preferable. In addition, the number of times of administration (administration) is not limited, and it can be taken 1 to 20 times per day (administration).

The effective amount of (B) rooibos extract is preferably 1 to 10,000 mg / day, more preferably 10 to 1,000 mg / day, more preferably 20 to 500 mg / day, in the case of a dried product of rooibos extract Do. Such an amount may be ingested once a day (administration) or divided into a plurality of times (1 to 20 times) per day. When ingested (administered) in multiple divided doses, the amount is preferably 5 to 50,000 mg / s, more preferably 50 to 10,000 mg / s, more preferably 100 to 5,000 mg / s, in terms of dry rooibos before extraction .

The method of administration of the agent of the present invention is not particularly limited and may be oral or parenteral. The formulations are not particularly limited, and solid, liquid, gel, cream, paste and the like can be appropriately selected. Among them, oral form is preferable, and known formulations such as powders, tablets, disintegrating tablets in the mouth, chewable tablets, capsules, films, sprays, liquid preparations and the like can be selected. The solid may be dissolved in a liquid such as water, or the liquid may be diluted with water to be ingested (administered). Among them, intraoral disintegrating tablets, chewing tablets and sprayers are preferable.

[Oral Oral Composition]

The present invention provides oral or anti-wrinkle compositions containing (A) poly glutamic acid and / or salt thereof and (B) Aspalathus linearis extract. As described above, since the above-mentioned effects can be obtained by a combination of these, it is possible to provide a composition containing the extract of Aspalathus linearis as an active ingredient, a composition for promoting saliva secretion, , Oral cavity or oral care composition for imparting water in the oral cavity.

The content of (A) polyglutamic acid and / or its salt in the composition is preferably 0.001 to 50 mass%, more preferably 0.01 to 10 mass%. (Dry matter equivalent) of the extract (B) of Aspalathus linearis is preferably from 0.0001 to 80 mass%, more preferably from 0.001 to 70 mass%, and even more preferably from 0.01 to 60 mass% .

(A) component represented by (A): polyglutamic acid and / or salt thereof / (B): Aspalathus linearis extract (dry matter equivalent) in the agent and composition of the present invention And the component (B) is preferably 0.001 to 1,000 / 1, more preferably 0.01 to 100/1. If this ratio is less than 0.001 / 1, there is a possibility that the effect of inhibiting oral dryness may be deteriorated. On the other hand, if it is larger than 1,000 / 1, there is a possibility that the effect of imparting water in the mouth may be deteriorated. The dosage form is preferably 0.001 to 1,000 / 1, more preferably 0.002 to 100/1, and even more preferably 0.005 to 10/1 in the case of a solid agent such as tablets or the like such as disintegrating tablets in the oral cavity or chewable tablets. In the case of a liquid agent such as a spray agent, the amount is preferably 0.001 to 1,000 / 1, more preferably 1 to 100/1, still more preferably 50 to 100/1.

The oral composition is intended to be used mainly in the oral cavity, and includes (i) ingestible and (ii) post-use. Concretely, (i) Trochia, a composition for a mouthful cooling agent, etc., which can be ingested, may, for example, be mentioned. (Ii) a dental composition such as a lotion dentifrice, a liquid dentifrice, a liquid dentifrice, a powder dentifrice, a cortex composition, a rinse composition, an oral application composition, Oral pasta, denture stabilizer composition, and the like. However, the oral coating composition, oral pasta, and the like may contain ingestible ingredients.

The underwear composition is not particularly limited as "intended for oral ingestion", and includes pharmaceuticals, foods for specific health use, foods, and the like. Examples of the food or food for a specific health include foods such as soft drinks, soft drinks, nutritional drinks, powder drinks, fruit drinks, milk beverages, jellies, etc. in addition to staying long in the oral cavity such as candy, chewing gum, lemonade, Beverages, foods, processed foods such as stocks (cereals such as rice and barley, cotton, bread, cereal), confectionery, dairy products, meat, fish, fruits and vegetables, and seasonings , And is not particularly limited.

The composition for oral use and the composition for oral cavity are not particularly limited and may be appropriately selected from solid, liquid, gel, cream, paste and the like as powder, tablet, Capsules, films, spray agents and the like may also be appropriately selected.

Among them, it is preferable to stay long in the oral cavity, and candy, chewing gum, lemonade, and gummy are preferable, and the oral cavity disintegrating tablet, chewing tablet, spray agent and the like are preferable.

The agent or composition of the present invention may contain a conventional amount in addition to the rooibos extract as long as the effect of the present invention is not impaired by any ingredient used in each preparation or composition. Examples of optional components include additives such as excipients, diluents, buffers, perfumes, colorants, defoaming agents, coating agents, mating agents, binders, surfactants, moisturizers, thickeners, lubricants, suspending agents, preservatives, chelating agents, antioxidants, , A thickener, a binder, a pH adjuster, a polishing agent, a medicament, and a solvent. These may be used alone or in combination of two or more.

In particular, in the case of compositions for liquid oral cavity such as fresh liquid and pasty oral cavity compositions, a viscoating agent, a binder, a surfactant and the like may be added. In the case of a dentifrice composition, an abrasive may be blended. In the case of a liquid oral composition such as a spray, a surfactant, a solvent and the like may be added.

The method of ingesting the agent and the composition of the present invention is not particularly limited and may be appropriately selected and may be set at the time when the oral cavity is dried or may be set at one day. The number of times of recovery is not particularly limited, and is appropriately selected within the range of, for example, 1 to 20 times.

The present invention can also provide the following invention. The optimum components, amounts, and the like are as described above. (1) Use of polyglutamic acid and / or salt thereof and Aspalathus linearis extract for producing the saliva secretion promoter, oral dry inhibitor or oral water-dispersing agent, (2) Use of polyglutamic acid and / or a salt thereof and Aspalathus linearis extract for the preparation of a composition or an underwear composition, wherein said composition comprises said saliva secretion enhancer, oral dry inhibitor or oral buccal agent (3) the oral composition or the oral care composition is compounded with the saliva secretagogue, the oral dry inhibitor or the oral water-holding agent, and the saliva secretion effect, A method for imparting an effect of inhibiting oral dryness or imparting a water-borne effect to the mouth.

Example

EXAMPLES Hereinafter, the present invention will be described in detail by way of examples and comparative examples, but the present invention is not limited to the following examples. In the following examples, unless otherwise specified, "%" of the composition represents mass%, and the ratio represents the mass ratio.

[Test Example 1] Saliva secretion promoting action

20 ml of an aqueous solution (composition% (g / 100 ml)) of the composition shown in the following Table 1 was put into the mouth for 30 seconds and spit out. Then, saliva secretion amount was measured by nasal sputum method (measurement of saliva mass at rest for 30 minutes) (n = 5). The results (average value) are shown in Table 1 and Fig. Results are shown as 100% water (control). Sodium polyglutamate was prepared by using sodium? -Polyglutamate (4% aqueous solution viscosity: 35.5 mPa.s (25 占 폚)) manufactured by Meiji Food Matters Co., Ltd., and roubobse extract Powder MF (powder obtained by filtering the hot-water extract of young leaves fermented by rooibos and filtering and concentrating the filtrate, containing 10% of rooibos extract and 90% of dextrin) was used. The amount of rooibos extract in Table 1 is a net conversion (equivalent to dry weight).

[Test Example 2] Effect of inhibiting oral dryness · Effect of imparting water in mouth

Sensory evaluation of oral dry inhibitory action was carried out using an aqueous solution having the above composition. Specifically, evaluation was made 30 minutes after the spit was released. The feeling of inhibiting the drying of the mouth &quot; was evaluated by the following evaluation criteria. The results of the average values are shown in Table 1 and FIG.

<Evaluation Criteria>

7 points; I felt very much · I felt very bitter

6 points; I felt · I felt the bite

5 points; I felt a bit · I felt some biting

4 points; We can not say either · We can not say either

3 points; I do not feel much · I do not feel much water

2 points; Do not feel · Do not feel the bite

1 point; I do not feel at all · I do not feel any bite

[Table 1]

As is clear from the above results, remarkable saliva secretion promoting effect, oral dry inhibitory effect, and oral water-holding effect can be obtained by combining polyglutamic acid and / or salt thereof and rooibos extract.

[Examples 1 to 13, Comparative Examples 1 to 3]

Tablets of the compositions shown in the following Tables 2 to 4 were tableted by the direct method using a rotary tablet machine (LIBURA2 manufactured by Kikusui Seisaku-sho, Ltd.). The sodium polyglutamate serving as the component (A) was prepared by using Meiji polyglutamic acid (sodium? -Polyglutamate, 4% aqueous solution viscosity: 35.5 mPa s (25 占 폚) As the fermented rooibos tea extract, which is a component (B), there is used a dried extract of rouvus tea, Maruizen Pharmaceutical Co., Ltd. (a hot-water extract of fermented young leaves of rooibos is filtered and the filtrate is concentrated and dried) As the non-fermented rooibos tea extract, green rooibos extract of Tama Biochemical Co., Ltd. (which is a powder obtained by filtering the hot-water extract of unfermented young leaves of rooibos and concentrating and drying the filtrate, containing 70% of rooibos extract and 30% of dextrin) was used . In addition, the amount of rooibos extract in the table is a net conversion amount (equivalent to dry mass). The tablets thus obtained were evaluated in the following manner.

[Test Example 3] Saliva secretion promoting action

Sensory evaluation of saliva secretion promoting action (5 persons) was performed using a tablet. Specifically, one tablet of tablets was chewed and evaluated 60 minutes after swallowing. &Quot; feeling that saliva secretion was promoted &quot; was evaluated by the following evaluation criteria.

<Evaluation Criteria>

◎: Five out of five responded that saliva secretion was promoted.

○: 3 to 4 out of 5 responded that the secretion of saliva was promoted.

△: 1 or 2 out of 5 responded that the saliva secretion was promoted.

X: 0 out of 5 responded that the saliva secretion was promoted.

[Test Example 4] Oral dry inhibitory effect

Sensory evaluation of oral dry inhibitory effect (5 persons) was performed by using a tablet. Specifically, one tablet of tablets was chewed and evaluated 60 minutes after swallowing. &Quot; feeling of inhibition of drying in the oral cavity &quot; was evaluated by the following evaluation criteria.

<Evaluation Criteria>

◎: Five out of five answer that we felt that drying in mouth was suppressed.

○: Three to four out of five responded that drying in mouth was suppressed.

△: One or two out of five responded that drying in mouth was suppressed.

×: 0 out of 5 answered that drying in mouth was suppressed.

[Test Example 5] Water-borne effect in oral cavity

Tablets were used to evaluate sensory evaluation of mouth watering effect (5 persons). Specifically, one tablet of tablets was chewed and evaluated 60 minutes after swallowing. &Quot; feeling that water was given in the oral cavity &quot; was evaluated by the following evaluation criteria.

<Evaluation Criteria>

◎: Five out of five answer that we felt that moisture was given in mouth.

○: Three to four out of five responded that they felt moisture was given to the mouth.

△: One or two out of five responded that they felt that water was given to the mouth.

×: 0 out of 5 responds that you feel that moisture is given in the mouth.

[Table 2]

[Table 3]

[Table 4]

[Examples 14 to 25 and Comparative Examples 4 to 5]

Spray agents having the compositions shown in Tables 5 to 7 were prepared by mixing each component and mixing with a stirrer. 30 g of the thus prepared liquid was charged into a spray container (Y-70 dispenser manufactured by Yoshino Kogyo Co., Ltd., nozzle hole 0.55 mm, spray amount of 1 push about 0.07 ml, volume 30 ml polyethylene terephthalate bottle). The obtained spray agent was evaluated in the following manner.

[Test Example 6] Saliva secretion promoting action

Sensory evaluation of saliva secretion promoting action (5 persons) was carried out using a spraying agent. Specifically, the test formulation was sprayed into the mouth of 5 push (about 0.35 ml), and evaluation was carried out after 30 minutes. &Quot; feeling that saliva secretion was promoted &quot; was evaluated by the following evaluation criteria.

<Evaluation Criteria>

◎: Five out of five responded that saliva secretion was promoted.

○: 3 to 4 out of 5 responded that the secretion of saliva was promoted.

△: 1 or 2 out of 5 responded that the saliva secretion was promoted.

X: 0 out of 5 responded that the saliva secretion was promoted.

[Test Example 7] Oral dry inhibitory effect

Sensory evaluation (5 persons) of oral dry inhibitory effect was carried out using a spraying agent. Specifically, the test formulation was sprayed into the mouth of 5 push (about 0.35 ml), and evaluation was carried out after 30 minutes. &Quot; feeling of inhibition of drying in the oral cavity &quot; was evaluated by the following evaluation criteria.

<Evaluation Criteria>

◎: Five out of five answer that we felt that drying in mouth was suppressed.

○: Three to four out of five responded that drying in mouth was suppressed.

△: One or two out of five responded that drying in mouth was suppressed.

×: 0 out of 5 answered that drying in mouth was suppressed.

[Test Example 8] Wetting effect in the oral cavity

Sensory evaluation of the water-holding effect in the oral cavity (5 persons) was carried out using a spraying agent. Specifically, the test formulation was sprayed into the mouth of 5 push (about 0.35 ml), and evaluation was carried out after 30 minutes. &Quot; feeling that water was given in the oral cavity &quot; was evaluated by the following evaluation criteria.

<Evaluation Criteria>

◎: Five out of five answer that we felt that moisture was given in mouth.

○: Three to four out of five responded that they felt moisture was given to the mouth.

△: One or two out of five responded that they felt that water was given to the mouth.

×: 0 out of 5 responds that you feel that moisture is given in the mouth.

[Table 5]

[Table 6]

[Table 7]

The above-described embodiment exhibits an effect of accelerating saliva secretion promotion, oral dryness suppression effect, and wettability in the oral cavity as in the above embodiment.

[Example 26]

Three solutions (pH 7.5)

                                      Furtherance

(A) Sodium polyglutamate 0.1

(B) Fermented rooibos tea extract 0.01

Polyoxyethylene hydrogenated castor oil (60) 0.5

Propylene glycol 3

Glycerin 4.5

Xylitol 3

Ethanol 2

Citric acid 0.07

Sodium citrate 0.25

Saccharin sodium 0.004

Fragrance 0.2

Purified water Remainder

Total 100.0%

(A) / (B) = 1/1

[Example 27]

chewing gum

                                      Furtherance

(A) Sodium polyglutamate 1.0

(B) Fermented Rooibos Tea Extract 1.0

Gum Base 19.6

Maltitol 22.8

Xylitol 19.6

Reduction syrup 1.3

Scralos 0.07

Perfume 1.96

(Sugar portion of sugar)

Arabian Rubber 1.9

Dextranazine preparation 0.1

Fragrance 0.2

Carnauba wax 0.04

Maltitol Remainder

Total 100.0%

(A) / (B) = 1/1

As is apparent from the above results, the combination of the polyglutamic acid and / or its salt as the component (A) and the roubus extract as the ingredient (B) significantly improved saliva secretion promoting effect, oral dry inhibitory effect, The effect of wetting in the mouth, and the effect of removing stickiness in the mouth can be obtained.

Details of the above examples and various components used in the above comparative examples are shown in the following table. The amount in the table is the net conversion amount.

[Table 8]

Claims (8)

A saliva secretion promoter comprising (A) a polyglutamic acid and / or a salt thereof, and (B) an extract of Aspalathus linearis as an active ingredient. An oral dry inhibitor characterized by containing (A) polyglutamic acid and / or its salt and (B) Aspalathus linearis extract as an active ingredient. Or a salt thereof, and (B) an extract of Aspalathus linearis as an active ingredient. (A) polyglutamic acid and / or a salt thereof, and (B) an extract of Aspalathus linearis. A composition for promoting saliva secretion promotion or an oral composition for promoting saliva secretion, which comprises (A) polyglutamic acid and / or salt thereof and (B) Aspalathus linearis extract as an active ingredient . An oral composition for oral dry inhibition or an oral composition for oral dry inhibition, which comprises (A) polyglutamic acid and / or its salt and (B) Aspalathus linearis extract as an active ingredient . A composition for oral application of water for oral use or a composition for imparting water in oral cavity, which comprises (A) a polyglutamic acid and / or a salt thereof and (B) Aspalathus linearis extract as an active ingredient Underwear composition. 8. The method according to any one of claims 4 to 7,
Wherein the content of (A) polyglutamic acid and / or salt thereof is 0.001 to 50 mass%, and (B) the content of Aspalathus linearis extract is 0.0001 to 80 mass%.

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