CN107613999B

CN107613999B - Saliva secretion promoter, xerostomia inhibitor, and oral moistening agent

Info

Publication number: CN107613999B
Application number: CN201680031861.3A
Authority: CN
Inventors: 岩井崇郎; 物井则幸; 铃木苗穗; 曾我晶子
Original assignee: Lion Corp
Current assignee: Lion Corp
Priority date: 2015-06-04
Filing date: 2016-06-03
Publication date: 2021-07-20
Anticipated expiration: 2036-06-03
Also published as: CN107613999A; JPWO2016195089A1; KR20180011058A; JP6841222B2; WO2016195089A1

Abstract

A salivation promoter contains polyglutamic acid and/or its salt and extract of south Africa black bush tea as effective components.

Description

Saliva secretion promoter, xerostomia inhibitor, and oral moistening agent

Technical Field

The present invention relates to a salivation accelerator, an oral dryness inhibitor, an oral cavity moistening agent, and a composition.

Background

Dry mouth (dry mouth) means that the saliva secretion is reduced, the quality of saliva is abnormal, the throat is thirsty, and the mouth is dry, so that pain and unpleasant feeling are caused. This is followed by viscous discomfort, conversation difficulties, development of bad breath, etc. When it becomes more morbid, generation of caries, periodontal disease, various infectious diseases, etc. due to changes in the oral flora is not only an insufficiency of oral function but also an insufficiency of general health.

Examples of symptomatic treatments include a method of moisturizing the oral cavity by artificial saliva, oral moisturizing, a humectant, and the like, but the problem is not fundamentally solved. Based on this fact, promotion of secretion of saliva and moistening of the oral cavity are important in keeping the oral cavity cool and refreshing and preventing oral diseases and systemic diseases. As the salivation accelerator, polyglutamic acid and salts thereof are exemplified, but a technique having a more excellent salivation accelerating effect is desired.

Documents of the prior art

[ patent document ]

[ patent document 1] Japanese patent application publication No. 2010-520913

[ patent document 2] Japanese patent laid-open No. 2008-24620

[ patent document 3] Japanese patent application laid-open No. 2006-117563

[ patent document 4] Japanese patent laid-open No. 2000-239136

[ patent document 5] International publication WO 2005/049050

Disclosure of Invention

Problems to be solved by the invention

The present invention has been made in view of the above circumstances, and an object thereof is to provide a salivation accelerator, an oral dryness inhibitor, an oral moistening agent, and oral and internal compositions that are effective for improving dry mouth.

Means for solving the problems

The present inventors have conducted intensive studies to achieve the above object and as a result, have found that saliva secretion is promoted, dryness in the oral cavity is alleviated, and the sticky feeling of discomfort is removed by combining polyglutamic acid and/or a salt thereof with an extract of red bush tea (ASPALATHUS LINEARIS) in south africa, thereby completing the present invention.

Accordingly, the present invention provides the following agents and compositions.

[1] A salivation accelerator comprising (A) polyglutamic acid and/or a salt thereof and (B) an extract of black bush tea in south Africa as active ingredients.

[2] An oral dryness inhibitor comprising (A) polyglutamic acid and/or a salt thereof and (B) a extract of red bush tea in south Africa as active ingredients.

[3] An oral cavity moistening agent comprising (A) polyglutamic acid and/or a salt thereof and (B) extract of red bush tea in south Africa as active ingredients.

[4] An oral composition or an oral composition comprising (A) polyglutamic acid and/or a salt thereof and (B) a south Africa black bush tea extract.

[5] An oral composition for promoting salivation or an internal composition for promoting salivation, which contains (A) polyglutamic acid and/or a salt thereof and (B) an extract of red bush tea in south Africa as active ingredients.

[6] An oral composition for inhibiting xerostomia or an internal composition for inhibiting xerostomia, which contains (A) polyglutamic acid and/or a salt thereof and (B) an extract of red bush tea in south Africa as active ingredients.

[7] An oral composition for imparting intraoral moisturization or an oral composition for imparting intraoral moisturization, comprising (A) polyglutamic acid and/or a salt thereof and (B) an extract of red bush tea in south Africa as active ingredients.

[8] The composition according to any one of [4] to [7], wherein the content of (A) the polyglutamic acid and/or the salt thereof is 0.001 to 50% by mass, and the content of (B) the extract of red bush tea in south Africa is 0.0001 to 80% by mass.

Drawings

Fig. 1 is a graph showing salivation-promoting effects of polyglutamic acid and/or a salt thereof and a extract of south african black bush tea.

Fig. 2 is a graph showing the oral dryness-suppressing effect and the oral moistening-imparting effect of polyglutamic acid and/or its salt and the extract of south african black bush tea.

Detailed Description

The present invention will be described in detail below.

The present invention provides a saliva secretion promoter, an oral dryness inhibitor, and an oral cavity moistening agent, each containing (A) polyglutamic acid and/or a salt thereof and (B) an extract of south Africa black bush tea as active ingredients.

[ (A) polyglutamic acid and/or salt thereof ]

As the polyglutamic acid, chemically synthesized α or γ -polyglutamic acid, or natural α or γ -polyglutamic acid obtained as a fermentation product from various strains, or a salt thereof can be used. In this case, natural polyglutamic acid is preferable in view of the addition to oral compositions and foods, and γ -polyglutamic acid which can be industrially produced in large quantities is most preferable. The polyglutamic acid may be in D form or L form. Polyglutamic acid is insoluble in water, but becomes water-soluble when it becomes a salt. Examples of the salt in this case include sodium salt, potassium salt, magnesium salt, calcium salt, ammonium salt, ethanolamine salt, basic amino acid salt, etc., and sodium or potassium salt is preferable. The degree of neutralization of the salt used in the present invention can be arbitrarily selected depending on the purpose within the range of pH1 to pH14 in a 1 mass% aqueous solution thereof.

The viscosity of the polyglutamic acid or a salt thereof is not particularly limited, and various viscosities can be used depending on the kind of the product, and the viscosity of a 4 mass% aqueous solution measured by the method described later is preferably 10 to 200mPa · s, more preferably 30 to 120mPa · s.

Viscosity measurement method

96g of water was put in a 200mL beaker, and 4.0g of polyglutamic acid or a salt thereof was added thereto with stirring with a stirrer to completely dissolve the polyglutamic acid or the salt thereof. Subsequently, the mixture was left to stand in a constant temperature water bath at 25 ℃ for 1 hour, and then the viscosity after 1 minute was measured accurately using a BL type viscometer described below.

BL type viscometer: tokyo counter: type B viscometer, style: BL, rotor: no.2, rotation speed: 60rpm, measurement temperature: 25 deg.C

As the polyglutamic acid or a salt thereof, commercially available products can be used, and for example, as the sodium γ -polyglutamate, Mingmeng polyglutamic acid manufactured by Mingmg food materials Co.

[ (B) extract of south Africa Red Bush tea ]

South Africa red bush tea (Aspalathus LINEARIS) also known as Rooibos (hereinafter sometimes abbreviated as "Rooibos") belongs to the genus of Leguminosae (Fabaceae) Aspalathus. The lewis basic substance is not particularly limited as long as the effect of the present invention can be obtained by a method generally used for extraction of plants. In addition, commercially available powder of the extract of Rooibos tea can be used.

The site for the extraction of lewy is not particularly limited and may be appropriately selected. Examples of the material include a leaf part, a new leaf part, a branch part, a trunk part, a bark part, a flower part, an fruit part, and a root part. Among them, the new leaf part and the branch part are preferable.

The Lewis used for the extraction may be either a fermented product or an unfermented product. The fermented product refers to a product obtained through an oxidation step, and the unfermented product refers to a product fermented without the oxidation step. The oxidation step of fermentation is not particularly limited, and a generally used method can be used. For example, the oxidation step is an oxidation step in which the mixture is incubated at 20 to 40 ℃ in the presence of water, or an oxidation step in sunlight.

The above-mentioned lewis acid extract can be obtained by further subjecting the above-mentioned extract to a pulverization treatment using a coarse pulverizer, a drying treatment, or a combination thereof, and then subjecting the resultant to a solvent extraction as described later. The drying treatment is not particularly limited, and a method generally used may be used. For example, it is preferably carried out at 60 ℃ or lower.

The extraction method is not particularly limited and may be appropriately selected. For example, the extract can be obtained by pouring the extraction site of lewis as the extraction raw material into a treatment tank filled with an extraction solvent, eluting the soluble component with appropriate stirring as necessary, and then filtering to remove the extraction residue.

The extraction solvent is not particularly limited and may be appropriately selected. For example, water, a hydrophilic solvent, a hydrophobic solvent, or a mixed solvent of these solvents can be exemplified. Examples of the water include pure water, tap water, well water, mineral water, hot spring water, fresh water, pure water, hot water, ion-exchanged water, physiological saline, phosphoric acid buffer solution, phosphoric acid-buffered physiological saline, and the like. Examples of the hydrophilic solvent include lower alcohols having 1 to 6 carbon atoms such as methanol, ethanol, propanol, and isopropanol; lower aliphatic ketones such as acetone and methyl ethyl ketone; and C2-6 polyhydric alcohols such as 1, 3-butanediol, propylene glycol, and glycerin. Examples of the hydrophobic solvent include aromatic carbons such as benzene and toluene; organic solvents such as ethyl acetate, acetonitrile, ether and the like; and halocarbons such as methylene chloride and chloroform. The solvent mixture is not particularly limited, and the water, the hydrophilic solvent, and the like may be appropriately mixed and used. The ratio of the mixed solvent is preferably such that 1 to 90 parts by mass of a lower alcohol, a lower aliphatic ketone, a polyhydric alcohol, etc. are added to 10 parts by mass of water. The extraction solvent is preferably water, ethanol, or a mixture of water and ethanol, more preferably a 0 to 20 mass% aqueous ethanol solution, and even more preferably water.

The amount of the extraction solvent used is not particularly limited, and may be appropriately selected depending on the extraction solvent, the extraction method, and the like. For example, 1 to 1,000 parts by mass of an extraction solvent can be used per 1 part by mass of the extraction site.

The extraction conditions (extraction time and extraction temperature) are not particularly limited, and may be appropriately selected depending on the extraction method such as the extraction solvent. When the solvent is water, the extraction temperature is preferably from room temperature to hot water, and more preferably hot water.

The lewis basic substance may be used after purification according to need, and the purification method is not particularly limited and may be appropriately selected. For example, purification methods such as liquid-liquid partition extraction, various chromatography, membrane separation, and supercritical fluid extraction can be exemplified.

Specific embodiments of the lewis basic extract are not particularly limited and may be appropriately selected, and for example, the extract itself, a dried product of the extract, a diluted solution of the extract, a dried product of a diluted solution of the extract, a concentrated solution of the extract (concentrated extract), a dried product of a concentrated solution of the extract, a powder of the dried product, or the like may be used. As the extract, an aqueous extract is preferred, and a hot water extract is particularly preferred.

As the lewis extract, for example, commercially available lewis tea extract can be used. Examples of commercially available extract of Rooibos tea include powder obtained by filtering hot water extract of fermented fresh leaves of Rooibos and concentrating and drying the filtrate.

[ salivary secretion promoters ]

The combination of the polyglutamic acid and/or its salt (a) and the lewis acid extract (B) can provide a remarkable salivation-promoting effect which cannot be obtained by the individual use of the components. The present invention provides a salivation accelerator containing the compound as an active ingredient.

[ xerostomia inhibitor ]

By combining the polyglutamic acid and/or its salt (a) and the lewis acid extract (B), a remarkable salivation-promoting effect which cannot be obtained by using them alone can be obtained, and an effect of suppressing the dryness in the oral cavity can be obtained. The present invention provides a xerostomia inhibitor containing the same as an active ingredient.

[ oral Cavity moistening agent ]

By combining the polyglutamic acid and/or its salt (a) and the lewis acid extract (B), a remarkable salivation-promoting effect which cannot be obtained by using them alone can be obtained, and an effect of imparting moistness to the oral cavity can be obtained. The present invention provides an oral cavity moistening agent containing the compound as an active ingredient.

(A) The amount of polyglutamic acid and/or a salt thereof added to each agent of the lewis acid extract (B) is appropriately selected depending on the dosage form, the form of intake (administration), and the subject of intake (administration). The effective amount to exert the intended effect of each agent such as promotion of salivary secretion is appropriately selected depending on the state, age, and the like of the subject to be ingested (administered), as shown below.

(A) The effective amount of polyglutamic acid and/or its salt is, for example, preferably 0.01 to 5,000 mg/day, more preferably 0.05 to 1,000 mg/day, and further preferably 0.1 to 500 mg/day for 1 adult per day. In addition, the number of times of ingestion (administration) is not limited, and 1 to 20 times of ingestion (administration) may be ingested per 1 day.

In the case of a dried form of the Lewis extract, the effective amount of the Lewis extract (B) is, for example, preferably 1 to 10,000 mg/day, more preferably 10 to 1,000 mg/day, still more preferably 20 to 500 mg/day. The dose may be taken (administered) 1 time per day, or may be taken (administered) in 1 day divided into a plurality of times (1 to 20 times). When the administration is divided into a plurality of times, the amount is preferably 5 to 50,000 mg/time, more preferably 50 to 10,000 mg/time, and still more preferably 100 to 5,000 mg/time in terms of dry Lewis before extraction.

The method of taking (administering) the agent of the present invention is not particularly limited, and may be oral or non-oral. The formulation is not particularly limited, and a solid, liquid, gel, cream, ointment, or the like can be appropriately selected. Of these, oral administration is preferable, and known dosage forms such as powder, tablet, orally disintegrating tablet, chewable tablet, capsule, film, spray, and liquid can be selected. Alternatively, the solid may be dissolved in a liquid such as water, and the liquid may be diluted with water and then ingested (administered). Among them, orally disintegrating tablets, chewable tablets and sprays are preferable.

[ oral or oral compositions ]

The present invention provides an oral or peroral composition containing (A) polyglutamic acid and/or its salt and (B) extract of south Africa black bush tea. As described above, the above-mentioned effects can be obtained by combining them, and therefore, the composition is suitably used as an oral cavity or an internal composition for promoting salivation, suppressing xerostomia, and imparting moistness to the oral cavity, which contains the above-mentioned agent or extract of south african black bush tea as an active ingredient.

The content of the polyglutamic acid and/or a salt thereof (a) in the composition is preferably 0.001 to 50% by mass, more preferably 0.01 to 10% by mass. (B) The content (dry matter equivalent) of the extract of south Africa black bush tea is preferably 0.0001 to 80% by mass, more preferably 0.001 to 70% by mass, and further preferably 0.01 to 60% by mass.

In the agent and composition of the present invention, (a): polyglutamic acid and/or salt thereof/(B): the addition mass ratio of the component (A) to the component (B) represented by the extract of south African black bush tea (dry matter equivalent) is preferably 0.001 to 1,000/1, more preferably 0.01 to 100/1. When the ratio is less than 0.001/1, the xerostomia-suppressing effect may be deteriorated. On the other hand, if the amount is larger than 1,000/1, the effect of imparting intra-oral moistening may deteriorate. In addition, the dosage form is preferably 0.001 to 1,000/1, more preferably 0.002 to 100/1, and still more preferably 0.005 to 10/1, in the case of a solid preparation such as an orally disintegrating tablet or a chewable tablet. In the case of a liquid such as a spray, the amount is preferably 0.001 to 1,000/1, more preferably 1 to 100/1, and still more preferably 50 to 100/1.

The oral composition is a "composition intended to be used mainly in the oral cavity", and examples thereof include (i) an ingestible composition and (ii) a composition discharged after use. Specifically, as the ingestible composition (i), for example, a tablet (troche), a mouth coolant composition, and the like can be exemplified. (ii) Examples of the composition to be discharged after use include dentifrice compositions such as toothpaste dentifrice, liquid dentifrice and powder dentifrice, mouth wash compositions, coating composition for oral cavity, paste for oral cavity, and denture stabilizer compositions. In some cases, the pack composition for oral cavity, the paste for oral cavity, and the like may contain an ingestible substance.

The oral composition is "a composition intended to be taken mainly orally", and is not particularly limited, and examples thereof include a pharmaceutical product, a specific health food, and a food. Examples of the specific health food or food include products staying in the oral cavity for a long time such as candies, chewing gums, soda pop, gummy candies (gummi), and beverages: cold drinks, carbonated drinks, nutritional drinks, powdered drinks, fruit drinks, milk drinks, jelly drinks, and the like, foods: the staple food (grains such as rice and wheat, noodles, bread, and cereals), snack, dairy product, meat, fish, processed product such as vegetables and fruits, and flavoring agent are not particularly limited.

The oral composition and the internal composition are not particularly limited, and may be appropriately selected from a solid, a liquid, a gel, a cream, an ointment, and the like, or may be appropriately selected from a powder, a tablet, an orally disintegrating tablet, a chewable tablet, a capsule, a film, a spray, and the like.

Among them, products staying in the oral cavity for a long time are preferable, and candies, chewing gums, soda pop, gummy candies are preferable, and orally disintegrating tablets, chewable tablets, sprays and the like are preferable as dosage forms.

In the agent or composition of the present invention, any component used in each agent or composition may be added in a usual amount within a range not impairing the effect of the present invention, except the lewis extract. Examples of the optional components include excipients, diluents, buffers, perfumes, colorants, antifoaming agents, coating agents, flavors, binders, surfactants, humectants, thickeners, lubricants, suspending agents, preservatives, chelating agents, antioxidants, abrasives, thickeners, binders, pH adjusters, gloss agents, drugs, solvents, and the like, and these may be used alone in 1 kind or in appropriate combinations of 2 or more kinds.

In particular, in the case of a liquid oral composition such as a mouthwash or a paste oral composition, a thickener, a binder, a surfactant, and the like may be added. In the case of a dentifrice composition, an abrasive may be added. In the case of a liquid oral composition such as a spray, a surfactant, a solvent, or the like may be added.

The method of taking (administering) the agent and composition of the present invention is not particularly limited, and may be appropriately selected, and the number of times of taking (administration) may be determined within 1 day, or may be taken (administered) when the oral cavity is dry. The number of times is not particularly limited, and may be appropriately selected from the range of, for example, 1 to 20 times.

The present invention can further provide the following inventions. The optimum components, amounts and the like are the same as those described above. (1) Use of polyglutamic acid and/or a salt thereof and an extract of black bush tea in south Africa for producing the above-mentioned salivary secretion promoter, xerostomia inhibitor or oral cavity moistening agent; (2) use of polyglutamic acid and/or a salt thereof and a south african red bush tea extract for the manufacture of the oral composition or the oral composition, wherein the composition is added with the salivation accelerator, the xerostomia inhibitor or the mouth moistening agent; (3) a method for imparting a salivation effect, a xerostomia-inhibiting effect or an intraoral moistening effect to the oral composition or the oral composition by adding the salivation accelerator, the xerostomia-inhibiting agent or the intraoral moistening agent to the oral composition or the oral composition.

[ examples ] A method for producing a compound

The present invention will be described in more detail below with reference to examples and comparative examples, but the present invention is not limited to the following examples. In the following examples, unless otherwise specified, "%" of the composition means mass%, and the ratio means a mass ratio.

[ test example 1] salivary secretion-promoting action

20mL of an aqueous solution having a composition shown in Table 1 below (composition% (g/100mL)) was taken in the mouth for 30 seconds and discharged. Then, the salivary secretion amount was measured by the spitting method (30 minutes, measuring the quality of saliva at rest) (n ═ 5). The results (average values) are shown in table 1 below and fig. 1. The results are shown as 100% water (control). As the sodium polyglutamate, gamma-polyglutamate (4% aqueous solution viscosity: 35.5 mPas (25 ℃ C.)) manufactured by Mingzhi food materials Co., Ltd. was used, and Rooibos tea extract powder MF (powder obtained by filtering hot water extract of fermented fresh leaf of Rooibos and concentrating and drying the filtrate, containing 10% Rooibos extract and 90% dextrin) manufactured by Wanzhi pharmaceutical manufacturing was used. The amount of the Lewis extract in Table 1 was calculated as the amount of purity (equivalent to dry mass).

[ test example 2] oral dryness-suppressing Effect and oral moistening-imparting Effect

Sensory evaluation of oral dryness inhibition was performed using the aqueous solution of the above composition. Specifically, evaluation was performed 30 minutes after the discharge. The "feeling of suppressed mouth dryness" was evaluated according to the following evaluation criteria. The results of the average values are shown in table 1 and fig. 2.

< evaluation criteria >

7 min; the feeling of strong feeling and the feeling of wetness

6 minutes; feeling of wetness

5 min; slight feeling of wetness

4, dividing; cannot be said to feel nor feel

3 min; make little sense of wetness

2 min; no feeling of wetness

1 minute; no feeling of wetness

[ TABLE 1]

From the above results, it was found that a combination of polyglutamic acid and/or a salt thereof and a lewis acid extract provides a remarkable salivation promoting effect, an effect of suppressing xerostomia, and an effect of imparting moisturization in the oral cavity.

Examples 1 to 13 and comparative examples 1 to 3

Tablets having the compositions shown in tables 2 to 4 below were tableted by a direct compression method using a rotary tablet press (LIBURA 2 manufactured by chrysanthemi water products co., ltd.). As the sodium polyglutamate of the component (A), Mingzhi polyglutamic acid (gamma-sodium polyglutamate, 4% aqueous viscosity: 35.5 mPas (25 ℃ C.)) manufactured by Mingzhi food materials Co., Ltd is used; the fermented Rooibos tea extract (B) is obtained by using dried Rooibos tea extract F (powder obtained by filtering hot water extract of fermented fresh leaf of Rooibos, concentrating and drying the filtrate) produced by pill pharmaceutical Co., Ltd; the unfermented Rooibos tea extract of component (B) was a green Rooibos extract (powder obtained by filtering hot water extract of unfermented fresh leaves of Rooibos, concentrating and drying the filtrate, and containing 70% of Rooibos extract and 30% of dextrin) manufactured by Tama Biochemical Co., Ltd. The amount of the lewis extract in the table is a purity equivalent (corresponding to dry mass). The following evaluations were performed on the obtained tablets.

[ test example 3] salivary secretion-promoting action

Sensory evaluation of salivation-promoting effect was performed using the tablets (5 persons). Specifically, 1 tablet was chewed and ingested, and evaluated 60 minutes after swallowing. The "sensation of promotion of secretion of saliva" was evaluated based on the following evaluation criteria.

Evaluation criteria

Very good: of the 5 people, 5 responded to the sensation that secretion of saliva was promoted.

O: 3 to 4 of 5 persons responded to the sensation of accelerated secretion of saliva.

And (delta): 1 to 2 of 5 persons responded to the sensation of accelerated secretion of saliva.

X: of the 5 persons, 0 person responded to the sensation that secretion of saliva was promoted.

[ test example 4] xerostomia-inhibiting effect

Sensory evaluation of the xerostomia-inhibiting effect was carried out using the tablets (5 persons). Specifically, 1 tablet was chewed and ingested, and evaluated 60 minutes after swallowing. The "feeling of inhibition of drying in the oral cavity" was evaluated based on the following evaluation criteria.

Evaluation criteria

Very good: of the 5 persons, 5 persons responded with a feeling of suppressed intraoral dryness.

O: 3 to 4 of 5 persons responded with a feeling of suppression of intraoral dryness.

And (delta): of 5 persons, 1 to 2 persons responded with a feeling of suppressed intraoral dryness.

X: of the 5 persons, 0 person responded with a sensation of suppression of intraoral dryness.

[ test example 5] intraoral moistening Effect

Sensory evaluation of the effect of imparting oral moistening was carried out using the tablets (5 persons). Specifically, 1 tablet was chewed and ingested, and evaluated 60 minutes after swallowing. The "feeling given by the intraoral moistening" was evaluated based on the following evaluation criteria.

Evaluation criteria

Very good: of the 5 persons, 5 persons responded to the sensation imparted by the intra-oral wetness.

O: 3 to 4 of 5 persons responded to the feeling given by the intraoral wetness.

And (delta): 1 to 2 of 5 persons responded to the feeling given by the intraoral wetness.

X: of the 5 persons, 0 person responded to the sensation imparted by the intraoral moistening.

[ TABLE 2]

[ TABLE 3]

[ TABLE 4]

Examples 14 to 25 and comparative examples 4 to 5

Each component was measured and mixed with a mixer to prepare sprays having compositions shown in tables 5 to 7 below. A spray container (a bottle made of polyethylene terephthalate having a volume of 30mL and a spray amount of about 0.07mL per push) was filled with 30g of the preparation solution (Y-70 dispenser manufactured by Ji Ye industries, nozzle hole 0.55 mm). The following evaluations were made for the obtained spray.

[ test example 6] salivary secretion-promoting action

Sensory evaluation of salivary secretion-promoting action was carried out using the spray (5 persons). Specifically, the test preparation was sprayed into the inlet by pressing 5 times (about 0.35mL), and the evaluation was performed after 30 minutes. The "sensation of promotion of secretion of saliva" was evaluated based on the following evaluation criteria.

< evaluation Standard >

[ test example 7] xerostomia-inhibiting effect

Sensory evaluation of xerostomia-inhibiting effect was performed using the spray (5 persons). Specifically, the test preparation was sprayed into the inlet by pressing 5 times (about 0.35mL), and the evaluation was performed after 30 minutes. The "feeling of inhibition of drying in the oral cavity" was evaluated based on the following evaluation criteria.

< evaluation Standard >

[ test example 8] intraoral moistening Effect

Sensory evaluation of the effect of imparting oral moistening was carried out using the spray (5 persons). Specifically, the test preparation was sprayed into the inlet by pressing 5 times (about 0.35mL), and the evaluation was performed after 30 minutes. The "feeling given by the intraoral moistening" was evaluated based on the following evaluation criteria.

< evaluation Standard >

O: 3 to 4 of 5 persons responded to the feeling given by the intraoral wetness.

[ TABLE 5]

[ TABLE 6]

[ TABLE 7]

The following examples show the same excellent saliva secretion promoting effect, oral dryness suppressing effect, and oral moistening effect as the above examples.

[ example 26]

Gargle (pH7.5)

(A)/(B)＝10/1

[ example 27]

Chewing gum

(A)/(B)＝1/1

As is clear from the above results, the combination of the polyglutamic acid and/or salt thereof as the component (a) and the lewis basic extract as the component (B) can provide a remarkable salivation promoting effect, an oral dryness suppressing effect, an oral moistening effect, and an oral viscosity removing effect.

The details of the respective components used in the above examples and comparative examples are shown in the following table. The amounts in the table are amounts converted to purity.

[ TABLE 8]

Claims

1. A salivation accelerator comprises (A) polyglutamic acid and/or its salt and (B) extract of black bush tea in south Africa in a mass ratio of (A/B) 0.001-1000 as active ingredients.

2. An oral dryness inhibitor comprising (A) polyglutamic acid and/or a salt thereof and (B) an extract of red bush tea in south Africa as active ingredients, wherein A/B is 0.001-1000 by mass.

3. An oral cavity moistening agent contains (A) polyglutamic acid and/or its salt and (B) extract of south Africa black bush tea as effective components, wherein the mass ratio A/B is 0.001-1000.

4. An oral composition or an oral composition comprising (A) polyglutamic acid and/or a salt thereof and (B) an extract of red bush tea in south Africa in a mass ratio of (A/B) 0.001 to 1000.

5. An oral composition or an oral composition for promoting salivation, which contains (A) polyglutamic acid and/or a salt thereof and (B) an extract of black bush tea in a mass ratio A/B of 0.001 to 1000 as active ingredients.

6. An oral composition for inhibiting xerostomia or an oral composition for inhibiting xerostomia, which contains (A) polyglutamic acid and/or a salt thereof and (B) an extract of red bush tea in south Africa as active ingredients in a mass ratio A/B of 0.001 to 1000.

7. An oral composition for imparting intraoral moisturization or an oral composition for imparting intraoral moisturization, comprising (A) polyglutamic acid and/or a salt thereof and (B) an extract of red bush tea in south Africa as active ingredients in a mass ratio A/B of 0.001 to 1000.

8. The composition according to any one of claims 4 to 7, wherein the content of (A) polyglutamic acid and/or its salt is 0.001 to 50% by mass and the content of (B) extract of red bush tea in south Africa is 0.0001 to 80% by mass.