KR20170142629A

KR20170142629A - Hydrogel pack with preventing ultra violet ray and method for preparing the same

Info

Publication number: KR20170142629A
Application number: KR1020160076412A
Authority: KR
Inventors: 오한선; 정영수
Original assignee: (주)뷰티화장품
Priority date: 2016-06-20
Filing date: 2016-06-20
Publication date: 2017-12-28

Abstract

The present invention provides a hydrogel pack which has UV blocking effects by comprising a microalgae extract containing phytoene and phytofluene as a UV blocking agent. Specifically, the hydrogel pack according to the present invention shows excellent UV blocking effects by containing an organic UV blocking agent and a natural UV blocking agent, and has low skin irritability, and thus may be effectively used for the daily UV protection purpose. Additionally, the hydrogel pack, when worn, continuously supplies moisture to the skin, thus keeping the skin moisturized and effectively calming skin troubles caused by radiant heat or an increase in body temperature, and can continuously supply various nutrient components to the skin, and thus may be used for various skin care purposes.

Description

[0001] The present invention relates to a hydrogel pack having an ultraviolet shielding function and a method for preparing the hydrogel pack,

The present invention relates to a hydrogel pack having an ultraviolet shielding function and a method for producing the same.

It is known that the amount of ultraviolet light irradiated on the surface is increasing due to ozone layer destruction. If the ultraviolet rays are excessively irradiated to the skin, it can cause damage to the skin such as skin erythema, burning, blackening or photoaging, and the market for the ultraviolet ray-shielding products is greatly growing every year.

Accordingly, recently, general cosmetics are manufactured by adding an ultraviolet shielding component, and ultraviolet shielding products are used in various forms such as creams, lotions, spray liquids, sticks, and tissue types for ultraviolet shielding.

On the other hand, most of the hydrogel packs are manufactured for indoor use for skin moisturizing, wrinkle and whitening purposes, and their compositions and ratios are used accordingly. For outdoor activities such as outdoor activities and leisure activities, In order to be used, ultraviolet ray shielding effect, adhesion force, sweat absorbing power and the like are not suitable. In the case of the hydrogel pack, although the ultraviolet ray shielding ability is given by using the organic ultraviolet ray blocking agent, when the organic ultraviolet ray blocking agent is used in an amount enough to effectively block the ultraviolet ray, It is necessary to study how to overcome these drawbacks because it causes physiological damage to the skin.

Korean Patent Laid-Open No. 10-2015-0066684 (Publication date: June 17, 2015) Korean Patent Publication No. 10-2014-0106930 (Publication date: 2014.09.04) Korean Patent Publication No. 10-2011-0072639 (published on June 29, 2011) Korean Patent Publication No. 10-2011-0010553 (published on February 21, 2011)

Disclosure of Invention Technical Problem [8] Accordingly, the present invention has been made keeping in mind the above problems occurring in the prior art, and an object of the present invention is to provide a hydrogel pack which can effectively prevent skin troubles by reducing the amount of a chemical organic ultraviolet screening agent, .

In order to accomplish the above object, the present invention provides a hydrogel pack having an ultraviolet shielding function by including a microalgae extract containing phytoene and phytofluene as an ultraviolet screening agent.

Further, the microalgae is hematoxylin nose kusu flu via-less (Haematococcus pluviali s), hematoxylin nose kusu Raku host group consisting of a lease (Haematococcus lacustris), Chlorella vulgaris (Chlorella vulgaris) and Ku analytic Ella four Renilla (Cunaliella sanila) And the like.

The ultraviolet light blocking agent may be at least one selected from the group consisting of octyl methoxycinnamate, drometrizole trisiloxane, drometrizole, digalloyl trioleate, Diethylaminobutylammonium hexamethylenediamine, disodium phenyl dibenzimidazole tetrasulfonate, diethylhexyl butamido triazone, diethylaminohydroxybenzoylhexyl benzoate, methylene bis-benzotriazolyl tetramethylbutylphenol, bis-benzotriazolyl tetramethylbutylphenol), 4-methylbenzylidene camphor, methylanthranilate, benzophenone derivatives, butyl methoxydibenzoylmethane, bisethyloxyl phenol Bis-ethylhexyloxyphenol methoxyphenyl triazine, But are not limited to, cinoxate, ethyldihydroxypropyl PABA, octocrylene, ethylhexyldimethyl PABA, ethylhexyl methoxycinnamate, ethylhexyl salicylate, salicylate, ethylhexyl triazone, isoamyl-p-methoxycinnamate, terephthalylidene dicamphor sulfonic acid, TEA-salicylate (TEA at least one organic UV-blocking agent selected from the group consisting of phenylsalicylic acid, salicylate, phenylbenzimidazole sulfonic acid and homosalate.

Also, the ultraviolet screening agent is characterized by comprising the mixture of phytoene and phytofluene: the organic ultraviolet screening agent in a weight ratio of 1: 1 to 1:20.

Further, the ultraviolet screening agent is contained in an amount of 0.1 to 5% by weight.

Further, the hydrogel pack may further include a support layer for imparting mechanical strength.

The present invention also provides a method for preparing a hydrogel matrix composition, comprising the steps of: preparing a hydrogel matrix composition in which a sunscreen agent containing a microalgae extract containing phytoene and phytofluene is dispersed; And combining the hydrogel matrix composition with a support layer to produce a hydrogel pack.

The hydrogel pack according to the present invention is excellent in ultraviolet ray shielding effect as an organic sunscreen agent and a natural ultraviolet screening agent, and can be effectively used for ultraviolet ray shielding in everyday life because of less skin irritation.

In addition, by continuously supplying moisture to the skin when worn, it is possible to effectively calm skin troubles caused by radiant heat or body temperature rise as well as maintaining moisturization of the skin, continuously supplying various nutrients to the skin, It can be used for various purposes.

1 is an actual image of a hydrogel pack having an ultraviolet shielding function according to the present invention.

Hereinafter, the present invention will be described in detail.

The present invention provides a hydrogel pack having an ultraviolet shielding function by including a microalgae extract containing phytoene and phytofluene as an ultraviolet screening agent.

The hydrogel pack is uniformly dispersed in the ultraviolet screening agent to protect the skin from ultraviolet rays in indoor and outdoor activities.

The ultraviolet screening agent may include an organic ultraviolet screening agent to effectively prevent ultraviolet rays. The ultraviolet screening agent may be selected from the group consisting of octyl methoxycinnamate, drometrizole trisiloxane, drometrizole, But are not limited to, diglycol trioleate, disodium phenyl dibenzimidazole tetrasulfonate, diethylhexyl butamido triazone, diethylaminohydroxybenzoylhexyl benzoate ( diethylaminohydroxybenzoylhexyl benzoate, methylene bis-benzotriazolyl tetramethylbutylphenol, 4-methylbenzylidene camphor, methylanthranilate, benzophenone derivatives, , Butyl methoxydibenzoylmeth ane, bis-ethylhexyloxyphenol methoxyphenyl triazine, cinoxate, ethyldihydroxypropyl PABA, octocrylene, ethylhexyldimethylparabe ethylhexyldimethyl PABA), ethylhexyl methoxycinnamate, ethylhexyl salicylate, ethylhexyl triazone, isoamyl-p-methoxycinnamate, , Terephthalylidene dicamphor sulfonic acid, TEA-salicylate, phenylbenzimidazole sulfonic acid, homosalate, or a mixture thereof may be used. .

However, in order to impart sufficient ultraviolet shielding ability to the hydrogel pack with the organic ultraviolet screening agent, the hydrogel pack prepared by using the organic ultraviolet screening agent in an appropriate amount, There is a problem in that it infiltrates into the eyes to induce skin troubles or irritation of the eyes, and cause physiological damage such as causing a photosensitizing reaction of the skin.

Accordingly, in the present invention, the natural ultraviolet screening agent can be included in the hydrogel pack together with the organic ultraviolet screening agent to reduce the content of the organic ultraviolet screening agent, thereby effectively preventing skin troubles due to skin penetration of the organic ultraviolet screening agent.

Python and phytopluene, which are natural ultraviolet ray blocking agents, are substances produced by microalgae, an autotrophic organism that produces organic matter through photosynthesis, and are carotenoid derivatives having an achromatic color in the visible light region and capable of effectively absorbing ultraviolet rays It can serve as an ultraviolet absorber. The above-mentioned python and phytofluroen are excellent in the ability to stabilize other molecules and scavenging radicals in the environment irradiated with sunlight, and in particular, python has an effect of causing erythema on the skin when exposed to ultraviolet rays, And effectively absorb UVB, which is ultraviolet ray of 320 to 400 nm, which is the main cause of skin blackening and photoaging, and can effectively be used as a natural sunscreen agent.

In this case, the microalgae hematoxylin nose kusu flu via-less (Haematococcus pluviali s), hematoxylin nose kusu Raku host-less (Haematococcus lacustris), Chlorella vulgaris (Chlorella vulgaris), Equus analytic Ella four Renilla (Cunaliella sanila) or a And the microalgae can be used as obtained from various microorganisms transformed with the genes of the microalgae.

As described above, the organic UV blocking agent and the hydrogel pack added with python and phytopluene which are natural sunscreen agents can minimize the physiological loss of the skin, and can minimize skin exposure to ultraviolet rays even in indoor and outdoor activities.

For this purpose, the ultraviolet screening agent may be composed of a mixture of python and phytofluene and the organic ultraviolet screening agent in a weight ratio of 1: 1 to 1:20, and the weight ratio may be adjusted to suit various skin types In addition, when incorporated into atopic skin, the content of python and phytofluene can be increased to minimize skin irritation, and when incorporated into general skin, the content of python and phytofluene can be lowered to reduce the manufacturing cost .

The ultraviolet screening agent may further include an inorganic ultraviolet screening agent such as titanium dioxide and zinc oxide to improve the ultraviolet screening ability of the hydrogel pack by the inorganic ultraviolet screening agent. The ultraviolet screening agent may include kaolin, talc, A filling agent such as a site, silica, or a mixture thereof may be added to reduce the light transmittance of the hydrogel pack and to enhance the ability of the nutrient to be supported.

In addition, the hydrogel pack may include 0.1 to 5% by weight of an ultraviolet screening agent, so that a sufficient ultraviolet ray blocking effect by the hydrogel pack can be expected when the user wears it. If the content of the ultraviolet screening agent is less than 0.1% by weight, it is difficult to expect a sufficient ultraviolet ray shielding effect. If the content is more than 5% by weight, further increase in ultraviolet ray shielding effect is not expected.

The above-mentioned hydrogel pack contains a water-soluble polymer, a large amount of water is filled in the lattice of the polymer to maintain a swollen three-dimensional structure, and a gel corresponding to an intermediate form of a liquid and a solid which maintains a stable shape after swelling in an aqueous solution Lt; / RTI > As a result, not only UV rays during outdoor activities but also continuous hydration by hydro gel pack calms radiation heat, facial heat, facial flushing, etc., so that the skin moisturizing effect Can be expected.

In addition, the hydrogel pack contains a water-soluble polymer, and the water-soluble polymer can sufficiently support various nutritional components such as a moisturizing agent and a whitening agent, so that the nutritional ingredient can be gradually released upon introduction into the skin, A conventional water-soluble polymer capable of effectively absorbing sweat or the like discharged from the skin can be used.

Particularly, the water-soluble polymer may be at least one selected from the group consisting of bio-cellulose, gelatin,? -Lactoglobulin, whey, soy protein, potato protein, hazelnut protein, wheat protein, poly-L-lysine, casein, casein, soybean glycine, Corn starch, methyl cellulose, ethyl cellulose, hydroxypropylmethyl cellulose, cellulose nitrate, carboxymethyl cellulose, gum arabic, xanthan gum, mesquat gum, guar gum, carrageenin, tragacanth gum, arabinogalactan , Galactomannan, pectin, agar, dextran, chitosan, zein, hydroxypropylmethylcellulose phthalate, hydroxypropylmethylcellulose acetate succinate, polyvinylacetate phthalate, poly (p-dioxanone), poly (? -valerolactone), poly (? -hydroxybutyrate), poly (? -hydroxybutyrate) and? -hydroxy valerate Poly (? -Hydroxypropionate), methyl acrylate copolymer, dimethylaminoethyl methacrylate copolymer, trimethylammonium ethyl methacrylate copolymer, polymers and copolymers of lactic acid and glycolic acid, lactic acid and glycolic acid And polymers and copolymers of polyethylene glycol, or mixtures thereof. Preferably, a bio-cellulose or fermented bio-cellulose made of natural materials is used, so that a good adhesion property of natural materials and a low- A hydrogel pack can be prepared.

Alternatively, a water-soluble polymer such as polyacrylic acid, sodium polyacrylate, polyacrylamide, polyvinyl alcohol, polyvinyl pyrrolidone or a mixture thereof can be used.

In addition, the hydrogel pack contains 3 to 20% by weight of a water-soluble polymer, 0.1 to 5% by weight of an ultraviolet screening agent, and the remainder of water so that a stable three-dimensional structure of the hydrogel is maintained, and sufficient UV- Effect can be expected.

Furthermore, the hydrogel pack may further comprise at least one additive selected from the group consisting of a whitening agent, a wrinkle-reducing agent, a moisturizer, a nutrient, a surfactant, and an antiseptic agent. , Preferably 0.5 to 5% by weight based on the total weight of the hydrogel pack, and can be suitably adjusted as necessary.

The whitening agent may be a whitening effect when the hydrogel pack is worn by using mulberry extract, oil soluble licorice extract, arbutin, ethyl ascorbyl ether, ascorbyl glucoside, niacinamide, alpha-bisabolol, ascorbyl tetraisopalmitate, As shown in FIG.

The wrinkle-improving agent can be expected to have a wrinkle-improving effect when the hydrogel pack is worn using retinyl palmitate, retinol, adenosine, or a mixture thereof.

The moisturizing agent may be glycerin, 1,3-butylene glycol, propylene glycol, dipropylene glycol, sorbitol, amino acids, peptides, or a mixture thereof. The polymeric polysaccharide such as maple extract, seaweed extract or snail mucus extract may be used And it is possible to expect a moisturizing effect on the skin when the hydrogel pack is worn by maintaining proper moisture.

The nutrient may be aloe vera extract, chamomile extract, grape seed oil, sunflower seed oil, or a mixture thereof. When the hydrogel pack is worn, sufficient nutrients may be supplied to the skin.

The surfactant may be polysorbate 20, 40, 80, rubolol W or the like commonly used for cosmetics, and phenoxyethanol may be used as a preservative.

In addition, the hydrogel pack may be constructed so as to additionally include essential oils extracted from natural leaves, thereby imparting flavor to the hydrogel pack and increasing the content of the effective ingredient of the natural leaf, thereby further improving the whitening and wrinkle reducing effect Pigments, natural pigments, and the like, which can be colored to give a sense of beauty and a beautiful color.

In addition, the hydrogel pack includes a support layer formed inside or on one surface of the hydrogel pack so as to support the hydrogel pack to give a sufficient mechanical strength and to prevent damage to the hydrogel pack.

The supporting layer may be a nonwoven fabric, but it may be made of various materials such as a synthetic film if it satisfies the required physical properties.

The above-described hydrogel pack may further comprise a release film layer formed on the other surface (that is, the skin attachment surface of the hydrogel pack) so as to protect the skin attachment surface of the hydrogel pack to which the support layer is bonded And the release film layer may be formed by forming a release film layer with a conventional release film such as a polyethylene film (PET film) or a polypropylene film such as CPP to protect the skin adhesion surface of the hydrogel pack.

The hydrogel pack according to the present invention has an excellent ultraviolet shielding effect due to the introduction of an organic ultraviolet screening agent and a natural ultraviolet screening agent, and can be effectively used for ultraviolet screening in everyday life because of less skin irritation.

The present invention also provides a method for preparing a hydrogel matrix composition, comprising the steps of: preparing a hydrogel matrix composition dispersed with a sunscreen agent comprising a microalgae extract comprising phytoene and phytofluene; And combining the hydrogel matrix composition with a support layer to produce a hydrogel pack.

It is preferable that the hydrogel matrix composition is prepared by first mixing and stirring purified water and water-soluble polymers, adding various nutrients and stirring, and then adding an ultraviolet screening agent so that ultraviolet screening components are mixed and dispersed more uniformly The gel matrix composition can be prepared, and if necessary, the heat treatment can be performed in parallel to increase the mixing and dispersibility.

The hydrogel matrix composition may be prepared by a method such as stirring, ultrasonic treatment, or the like, so as to contain various nutrients in a uniformly dispersed state and an ultraviolet screening agent.

The hydrogel matrix composition prepared as described above can be coated on the upper surface of the support member by using various commonly used coating methods to form a hydrogel layer. Thus, a hydrogel matrix layer is formed on the upper surface of the support member A hydrogel pack can be prepared.

Alternatively, after the hydrogel matrix composition is supplied to the mold, the support member is placed on the inner surface, or the hydrogel matrix composition is supplied to the mold in which the support member is fixed, Can be manufactured.

Hereinafter, the present invention will be described in more detail with reference to examples.

The embodiments presented are only a concrete example of the present invention and are not intended to limit the scope of the present invention.

<Examples>

(1) Extraction of natural sunscreen

The green microalgae Haematococcus pluvialis obtained from the Korea Ocean Research & Development Institute (KORDI) were inoculated into a sterile liquid medium (f / 2 Medium) Culture was performed. Some aliquots of subcultured microalgae were re-inoculated into another liquid medium (f / 2 Medium), and microscopic algae were cultured at 25 ° C under constant light condition (18 hours day, 6 hours night).

Distilled water was injected into the cultured microalgae and centrifuged at a speed of 5,000 rpm for 30 minutes to wash the culture, and then a pellet of the culture was obtained. The microbial extract was prepared by adding nucleic acid, chloroform, ethyl acetic acid, ethanol and water to each of the obtained cultured pellets, and the extract was concentrated using a vacuum decompression concentrator.

Standard substances were added to the concentrated extract, and the concentrated extract was subjected to reverse phase HPLC system with C18 column to obtain natural sunscreen agents phytoene and phytofluene from the extract, respectively.

(2) Preparation of Hydrogel Matrix Composition

Mixed with 1 g of bio-cellulose, 0.06 g of polyvinyl alcohol, 0.935 g of carrageenan, 0.7 g of xanthan gum, 0.814 g of carob bean gum, 0.07 g of guar gum, 0.07 g of agar, 0.035 g of potassium chloride and 0.035 g of glucose, And 0.2 g of a mixture of python and phytofluene and 0.3 g of a mixture of 2-benzophenone and ethylhexyldimethylparabe were added to the mixture thus prepared, followed by stirring. The mixture was homogenized with a homogenizer to obtain a hydro- Gel matrix composition was prepared.

(3) Preparation of hydrogel pack

The hydrogel matrix composition thus prepared was applied to a synthetic nonwoven fabric having a thickness of 0.5 mm (80% viscose rayon and 20% polypropylene) to a thickness of 0.2 mm to prepare a hydrogel pack.

<Comparative Example>

A hydrogel pack was prepared in the same manner as in Example except that 0.5 g of 2-benzophenone and ethylhexyldimethylparabe mixture was added in place of the python and phytofluene mixture to prepare the hydrogel matrix composition.

Experimental Example 1 Cytotoxicity analysis of the obtained python and phytofluene mixture

In order to perform the cytotoxicity analysis of the microalgae extract obtained by the method according to the Example, the proliferative activity of the skin cells was confirmed.

First, human keratinocytes (HaCaT) were cultured in the American Type Culture Collection (ATCC). The medium was DMEM (Dubelco's Modified Eagle Medium, BRL, USA) containing 10% FBS. Each of the cells was inoculated into a 24-well culture plate at a concentration of 1 × 10 ⁴ cells / ml, cultured for 48 hours, and cultured for 15 to 20% of the surface area of the culture container. The microalgae extract 2% by weight of FBS-free DMEM, and cultured for additional 24 hours.

50 μl of MTT (Sigma M5655, USA) solution (3 mg / ml) was added to the cultured medium (experimental group), and the supernatant was further removed for 3 hours. 200 μl of DMSO D2650, USA) was added and stirred for 20 minutes to dissolve the formed formazan crystals. 100 μl of each was dissolved in 96 wells and the absorbance was measured at 570 nm using enzyme immunoassay (ELISA). The degree of proliferative activity of skin cells was calculated as a percentage based on the absorbance of the control group using pure water according to the following formula.

[Mathematical Expression]

Cell survival rate (%) = [(absorbance of experimental group - absorbance of control group) / absorbance of control group]

As a result of the cytotoxicity analysis for analyzing the effect of the microalgae extract added to the skin cells, the cell survival rate of the skin cells cultured in the culture solution containing 2% by weight of the microalgae extract was 105.7%, and the control (100% ), The number of skin cells was increased. As a result, it was confirmed that the microalgae extract did not affect the survival rate of the cells, and it was confirmed that the microalgae extract did not have toxicity to the skin.

<Experimental Example 2> Ultraviolet blocking ability analysis

The UV blocking index of the hydrogel pack prepared by the method according to Examples and Comparative Examples was measured using an SPF-290S SPF analyzer.

As a result, it was confirmed that the hydrogel pack according to the example had an ultraviolet barrier index of 238 (SPF), and the hydrogel pack according to the comparative example had an ultraviolet barrier index of 241 (SPF) It can be confirmed that the hydrogel pack containing the phytofluene mixture has a similar ultraviolet shielding effect to the hydrogel pack containing the 2-benzophenone and ethylhexyldimethylparabe mixture, so that the hydrogel pack prepared by the method according to the embodiment It was confirmed that the gel pack can be effectively used for ultraviolet shielding.

Claims

A hydrogel pack with ultraviolet shielding function comprising a microalgae extract comprising phytoene and phytofluene as an ultraviolet screening agent.

The method according to claim 1,
Selected from the group consisting of the microalgae is hematoxylin nose kusu flu via-less (Haematococcus pluviali s), hematoxylin nose kusu Raku host-less (Haematococcus lacustris), Chlorella vulgaris (Chlorella vulgaris) and Ku analytic Ella four Renilla (Cunaliella sanila) Wherein the hydrogel pack is at least one kind selected from the group consisting of water,

The method according to claim 1,
Wherein the ultraviolet light blocking agent is selected from the group consisting of octyl methoxycinnamate, drometrizole trisiloxane, drometrizole, digalloyl trioleate, disodium phenyldibenzimidazole tetra But are not limited to, disodium phenyl dibenzimidazole tetrasulfonate, diethylhexyl butamido triazone, diethylaminohydroxybenzoylhexyl benzoate, methylene bis-benzotriazolyl tetramethylbutylphenol, benzotriazolyl tetramethylbutylphenol), 4-methylbenzylidene camphor, methylanthranilate, benzophenone derivatives, butyl methoxydibenzoylmethane, bisethyloxylphenol methoxy Bis-ethylhexyloxyphenol methoxyphenyl triazine, synoxate ( ethyloxycinnamate, cinnamate, cinnamate, ethyldihydroxypropyl PABA, octocrylene, ethylhexyldimethyl PABA, ethylhexyl methoxycinnamate, ethylhexyl salicylate, Ethylhexyl triazone, isoamyl-p-methoxycinnamate, terephthalylidene dicamphor sulfonic acid, tie-salicylate (TEA- salicylate, phenylbenzimidazole sulfonic acid, and homosalate. < Desc / Clms Page number 13 > 14. The hydrogel pack according to claim 1, wherein the organic UV-blocking agent is at least one selected from the group consisting of salicylate, phenylbenzimidazole sulfonic acid and homosalate.

The method of claim 3,
Wherein the ultraviolet screening agent comprises the mixture of phytoene and phytofluene: the organic ultraviolet screening agent in a weight ratio of 1: 1 to 1:20.

The method according to claim 1,
And 0.1 to 5% by weight of the ultraviolet screening agent.

The method according to claim 1,
And further comprising a support layer for imparting mechanical strength to the hydrogel pack.

Preparing a hydrogel matrix composition dispersed with a sunscreen agent comprising a microalgae extract comprising phytoene and phytofluene; And
And combining the hydrogel matrix composition with a support layer to produce a hydrogel pack.