KR20240045075A - Transparent patch for sunscreen comprising a composition for ultraviolet rays and composite skin improvement - Google Patents

Abstract

The present invention relates to a transparent patch for UV protection comprising a composition for blocking UV rays and complex skin improvement. Specifically, a cosmetic composition and biocellulose that exhibit excellent UV blocking effect despite being a completely transparent formulation and have a complex skin improvement effect at the same time. It concerns a UV-blocking patch made of a sheet.
The UV-blocking patch according to the embodiment can excellently improve the transdermal absorption of the active ingredients by applying loofah cucumber stem sap together with cosmetic active ingredients such as sunscreen, niacinamide, and adenosine.
Accordingly, the UV-blocking patch of the present invention shows excellent UV-blocking effect even though it is a completely transparent formulation, and has whitening, moisturizing, wrinkle-improving and skin texture-improving effects, and can exhibit excellent attachment, detachment and wearing comfort by using biocellulose, Since it does not wrinkle when attached, it can be stably attached to the face for a long time even during outdoor activities, especially when engaging in vigorous exercise or being exposed to strong sunlight for a long period of time.

Description

Transparent patch for UV protection containing a composition for UV protection and complex skin improvement {TRANSPARENT PATCH FOR SUNSCREEN COMPRISING A COMPOSITION FOR ULTRAVIOLET RAYS AND COMPOSITE SKIN IMPROVEMENT}

The present invention relates to a transparent patch for UV protection containing a composition for blocking UV rays and complex skin improvement. Specifically, a cosmetic composition and biocellulose that exhibit excellent UV blocking effect despite being a completely transparent formulation and have a complex skin improvement effect at the same time. It concerns a UV-blocking patch made of a sheet.

Loofah is a cucurbitaceae plant that is native to tropical Asia. In English, it is called ‘Sponge-gourd’ because the inside of the loofah is like a sponge, and in Chinese characters it is called ‘Apple’ because it has many threads. The genus name Lufa is the Arabic name for luffa cucumber (Luffa), and the specific epithet cylindrica is derived from the cylindrical shape of cylindricus, which comes from the shape of the luffa cucumber. It is presumed that it came to Korea through China, and its date is believed to be in the early 1900s. In Korea, sponge cultivation was carried out in Sangju, Goryeong, Uiseong, and Mungyeong in Gyeongbuk, Gongju and Seosan in South Chungcheong Province, and Gangwon-do. Ingredients and Use It is said that in the early 1970s, Japan imported a large amount of the sap obtained from cutting loofah cucumber stems to use it as a raw material for making beauty water (a lotion that moisturizes the skin and refines the skin surface). In fact, women in the countryside would plant loofah on the fence, and in midsummer, they would cut off the bottom of the stem, put the stem in a bottle, collect the sap from the scrub brush, and apply it to their faces. When used as a lotion, it smoothes the skin and is also good when applied to heat rashes.

100g of sap contains 5 kcal of energy, 98.1% moisture, 0.8 g protein, 0.7 g carbohydrate, 0.4 g ash, 2 mg calcium, 32 mg phosphorus, 0.2 mg iron, 3 mg sodium, 26 mg potassium, 0.07 mg vitamin B1, 0.08 mg vitamin B2, niacin. Contains 0.9mg and about 3mg of vitamin C. In addition, it contains sodium nitrate, saponin that does not dissolve well in water, a large amount of mucilage, and cyturulline, which is widely found in cucurbit plants.

This kind of loofah sap is used in cosmetics and health functional foods through its active ingredients such as saponin, but has not been applied to sunscreen patches. The present inventors applied loofah cucumber stem sap to a sunscreen patch along with cosmetic active ingredients such as sunscreen, niacinamide, and adenosine, and as a result, not only improved transdermal absorption but also increased the sunscreen effect and further improved attachment convenience. The present invention was completed by confirming its effectiveness.

Public Patent Publication No. 10-2021-0023155

Embodiments of the present invention seek to provide a transparent UV-blocking patch that has UV-blocking, whitening, moisturizing, wrinkle-improving, and skin texture-improving effects. In particular, we aim to provide a UV-blocking patch that can be used as a sunblock patch attached under the eyes when engaging in outdoor activities such as golf, has appropriate adhesion, and is comfortable to wear and does not wrinkle when attached.

The technical challenges to be achieved in the embodiments are not limited to the matters mentioned above, and other technical challenges not mentioned may be considered by those skilled in the art from the various embodiments described below. You can.

As one aspect for solving the above problem, the present invention is a sunscreen patch comprising a sheet containing a sunblock and complex skin improvement composition, wherein the sunblock composition includes loofah cucumber stem sap, an organic sunscreen, and niacin. Provided is a sunscreen patch containing amide and adenosine as active ingredients.

According to one embodiment, the composition for sunscreening and complex skin improvement includes 10 to 30 parts by weight of loofah cucumber stem sap, 10 to 30 parts by weight of an organic sunscreen, 20 to 50 parts by weight of niacinamide, and 0.1 to 2 parts by weight of adenosine. It may include

According to one embodiment, the organic sunscreen is glyceryl faba, drometrizole, digalloyl trioleate, 3-(4-methylbenzylidene)-camphor, methyl anthranilate, bis-ethylhexyloxyphenol methoxy. Phenyltriazine, diethylaminohydroxybenzoylhexylbenzoate, Benzophenone-3, Benzophenone-4, Benzophenone-8, Butylmethoxydibenzoylmethane, Cinoxate, Ethylhexyltriazone, Octylmethoxycinnamate, Octo Krylene, octyldimethylfaba, octylsalicylate, oxybenzone, cynoxate, octyltriazone, ethylhexylmethoxycinnamate, ethylhexylsalicylate, para-aminobenzoic acid, 2-phenylbenzimidazole-5- It may be any one or more selected from the group consisting of sulfonic acid, homosalate, isoamyl-p-methoxycinnamate, bisethylhexyloxyphenolmethoxyphenyltriazine, drometrizoletrisiloxane, and polysilicon-15. there is.

According to one embodiment, the UV blocking patch may be manufactured by containing the UV blocking and complex skin improvement composition in a patch layer made of a synthetic fiber sheet or a natural fiber sheet. At this time, the natural fiber sheet constituting the patch layer may be made of biocellulose, but is not limited thereto.

In addition, it may include a protective layer formed on the upper and lower portions of the patch layer to protect the patch layer and including a sheet made of a synthetic fiber sheet or a natural fiber sheet.

In particular, the sunscreen patch is completely transparent, and may be transparent or opaque before being impregnated with the sunscreen and complex skin improvement composition of the present invention, but is characterized by being transparent at least after being impregnated with the composition.

The UV-blocking patch of the example can be applied to the UV-blocking patch along with cosmetic active ingredients such as loofah cucumber stem sap, sunscreen, niacinamide, and adenosine, thereby significantly improving transdermal absorption of the active ingredients. Accordingly, it exhibits a UV blocking effect during the wearing period, and can even exhibit whitening, moisturizing, and wrinkle improvement effects through long-term wearing.

In particular, by applying the composition to a biocellulose sheet, it can exhibit excellent ultraviolet ray blocking effect even though it is a completely transparent formulation, as well as excellent attachment, detachment, and wearing comfort. Accordingly, the ultraviolet ray blocking patch of the embodiment can be stably attached to the face for a long period of time even during outdoor activities, especially during vigorous exercise.

Figure 1 is a graph showing the results of improved immediate skin moisturization when a sunscreen patch applied according to an embodiment of the present invention was attached.
Figure 2 shows some of the skin images confirming the results of improved immediate skin moisturization when a sunscreen patch to which an embodiment of the present invention was applied was attached.
Figure 3 is a graph showing the results of immediate improvement in skin elasticity when a sunscreen patch applied according to an embodiment of the present invention was attached.
Figure 4 is a graph showing the results of immediate improvement in skin transparency when attaching a sunscreen patch to which an embodiment of the present invention was applied.
Figure 5 is a graph showing the immediate skin lifting effect when a sunscreen patch to which an embodiment of the present invention is applied is attached.
Figure 6 shows some of the skin images confirming immediate skin lifting results when a sunscreen patch to which an embodiment of the present invention is applied is attached.
Figure 7 is a graph showing the immediate skin texture improvement effect when a sunscreen patch to which an embodiment of the present invention is applied is attached.
Figure 8 shows some of the skin images confirming the immediate skin texture improvement effect when applying the ultraviolet ray blocking patch to which an embodiment of the present invention is applied.
Figure 9 is a graph showing the results of improved long-term skin moisturization when attaching a sunscreen patch to which an embodiment of the present invention was applied.
Figure 10 is a graph showing the results of improvement in long-term skin elasticity when a sunscreen patch to which an embodiment of the present invention was applied was attached.
Figure 11 is a graph showing the results of improvement in long-term skin transparency when a sunscreen patch to which an embodiment of the present invention was applied was attached.
Figure 12 is a graph showing the long-term skin lifting effect when a sunscreen patch to which an embodiment of the present invention is applied is attached.
Figure 13 is a graph showing the long-term skin texture improvement effect when attaching a sunscreen patch to which an embodiment of the present invention is applied.

Hereinafter, embodiments will be described in detail with reference to the attached drawings. However, various changes can be made to the embodiments, so the scope of the patent application is not limited or limited by these embodiments. It should be understood that all changes, equivalents, or substitutes for the embodiments are included in the scope of rights.

Specific structural or functional descriptions of the embodiments are disclosed for illustrative purposes only and may be modified and implemented in various forms. Accordingly, the embodiments are not limited to the specific disclosed form, and the scope of the present specification includes changes, equivalents, or substitutes included in the technical spirit.

Terms such as first or second may be used to describe various components, but these terms should be interpreted only for the purpose of distinguishing one component from another component. For example, a first component may be named a second component, and similarly, the second component may also be named a first component.

When a component is referred to as being “connected” to another component, it should be understood that it may be directly connected or connected to the other component, but that other components may exist in between.

The terms used in the examples are for descriptive purposes only and should not be construed as limiting. Singular expressions include plural expressions unless the context clearly dictates otherwise. In this specification, terms such as “comprise” or “have” are intended to designate the presence of features, numbers, steps, operations, components, parts, or combinations thereof described in the specification, but are not intended to indicate the presence of one or more other features. It should be understood that this does not exclude in advance the possibility of the existence or addition of elements, numbers, steps, operations, components, parts, or combinations thereof.

Unless otherwise defined, all terms used herein, including technical or scientific terms, have the same meaning as generally understood by a person of ordinary skill in the technical field to which the embodiments belong. Terms defined in commonly used dictionaries should be interpreted as having a meaning consistent with the meaning in the context of the related technology, and unless explicitly defined in the present application, should not be interpreted in an ideal or excessively formal sense. No.

The advantages and features of the present invention and methods for achieving them will become clear by referring to the embodiments described in detail below along with the accompanying drawings. However, the present invention is not limited to the embodiments disclosed below and will be implemented in various different forms. The present embodiments only serve to ensure that the disclosure of the present invention is complete and that common knowledge in the technical field to which the present invention pertains is not limited. It is provided to fully inform those who have the scope of the invention, and the present invention is only defined by the scope of the claims.

In the embodiments of the present invention, unless otherwise defined, all terms used herein, including technical or scientific terms, are the same as those commonly understood by a person of ordinary skill in the technical field to which the present invention pertains. It has meaning. Terms defined in commonly used dictionaries should be interpreted as having a meaning consistent with the meaning in the context of the related technology, and unless clearly defined in the embodiments of the present invention, have an ideal or excessively formal meaning. It is not interpreted as

The shapes, sizes, proportions, angles, numbers, etc. disclosed in the drawings for explaining embodiments of the present invention are illustrative, and the present invention is not limited to the matters shown. Additionally, in describing the present invention, if it is determined that a detailed description of related known technologies may unnecessarily obscure the gist of the present invention, the detailed description will be omitted. When 'includes', 'has', 'consists of', etc. mentioned in this specification are used, other parts may be added unless 'only' is used. When a component is expressed in the singular, the plural is included unless specifically stated otherwise.

When interpreting a component, it is interpreted to include the margin of error even if there is no separate explicit description.

The size and thickness of each component shown in the drawings are shown for convenience of explanation, and the present invention is not necessarily limited to the size and thickness of the components shown.

Each feature of the various embodiments of the present invention can be partially or fully combined or combined with each other, and as can be fully understood by those skilled in the art, various technical interconnections and operations are possible, and each embodiment may be implemented independently of each other. It may be possible to conduct them together due to a related relationship.

The sunscreen patch herein includes a sunblock composition containing an active ingredient that exhibits a sunblock effect and a sheet containing the same. At this time, the UV blocking patch may be completely transparent.

First, the sunscreen composition contains loofah cucumber stem sap, organic sunscreen, niacinamide, and adenosine as active ingredients.

The loofah sap may preferably be collected from a Korean native scrub sponge. The loofah sap may be collected from the stem of a loofah that has grown more than 3 meters, by cutting a portion of about 1 meter in length exposed from the ground, and from this cut part. At this time, it is desirable to clean and disinfect the container receiving the sap and the stem part inserted into the container, and to collect it in a sealed state to prevent impurities such as rainwater or dust from entering the sap. It is known that the period during which sap of the same quality can be collected from the above cut part is within 6 days. The collection process may be performed using a sap collector.

Loofah cucumber stem sap itself has effective skin improvement effects, such as improving damage caused by UV rays, whitening effect, and moisturizing effect. In addition, loofah cucumber stem sap plays a key role in the adhesion of the patch and delivery of active ingredients in the present invention. Regarding the adhesion of the patch, optimal attachment stability and safe detachment effect can be improved through the biocellulose sheet described later.

Organic sunscreens can be used without limitation as long as they are used in the industry, and include glyceryl faba, drometrizole, digalloyl trioleate, 3-(4-methylbenzylidene)-camphor, methyl anthranilate, and bis. -Ethylhexyloxyphenolmethoxyphenyltriazine, diethylaminohydroxybenzoylhexylbenzoate, benzophenone-3, benzophenone-4, benzophenone-8, butylmethoxydibenzoylmethane, cynoxate, ethylhexyltriazone, Octylmethoxycinnamate, octocrylene, octyldimethylfaba, octylsalicylate, oxybenzone, cynoxate, octyltriazone, ethylhexylmethoxycinnamate, ethylhexylsalicylate, para-aminobenzoic acid, 2- A group consisting of phenylbenzimidazole-5-sulfonic acid, homosalate, isoamyl-p-methoxycinnamate, bisethylhexyloxyphenolmethoxyphenyltriazine, drometrizoletrisiloxane, and polysilicon-15. It may be any one or more selected from.

Niacinamide is a type of niacin, a member of the vitamin B group, and is a water-soluble vitamin B3, also known as nicotinamide. This niacinamide, along with ceramide, was confirmed to have the effect of simultaneously promoting the synthesis of cholesterol and fatty acids necessary for the formation of lamellar structures, thereby reducing water loss in the epidermis and improving lipid content. Niacinamide is essential for our bodies and is also contained in foods such as green vegetables and cereals. The need for niacinamide for healthy skin has been recognized since the early 20th century. When there is a lack of vitamin B3 in the diet, pellagra, an infectious disease that causes serious skin lesions, has emerged, and niacinamide has been known as a vitamin that prevents this. Niacinamide is known to have a whitening effect on the skin by inhibiting the movement of melanosomes from melanocytes to keratinocytes.

Adenosine binds to adenosine receptors in cells and helps skin function by promoting collagen formation, endothelial skin proliferation, and anti-inflammatory effects. Adenosine is a natural, safe, and widely used wrinkle-improving functional ingredient.

The sunscreen composition may include ingredients commonly used in cosmetic compositions in addition to the active ingredients, and the commonly used ingredients include conventional auxiliaries such as antioxidants, stabilizers, solubilizers, vitamins, pigments, and fragrances. , and may include a carrier.

The sunscreen composition can be formulated into a suspension, emulsion, cream, lotion, etc. by emulsifying the oil and water phases. More specifically, after forming a uniformly dispersed oil phase and dispersing the sunscreen and other active ingredients therein, a uniformly dispersed water phase containing loofah cucumber stem sap can be formed and slowly added to the oil phase for emulsification.

In forming an emulsion, a solubilizing or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butyl glycol oil, glycerol. There are aliphatic esters, fatty acid esters of polyethylene glycol or sorbitan.

Specifically, as a skin conditioning agent, glycerin, butylene glycol, hydrogenate polydecene, cetyl telhexanoate, pentaerythyl tetraisostearate, caprylic/capric triglycerite, dimethicone, It may include any one or more selected from the group consisting of arginine, star anise extract, caprylyl glycol, water-soluble collagen, gold extract, glucose, natto gum, sodium DNA, and ethylhexylglycerin.

Additionally, as a thickener, arachidyl alcohol, behenyl alcohol, cetearyl alcohol, xanthan gum, and carbomer may be included.

Additionally, an appropriate amount of surfactant may be included. Specifically, palmityl acid, stearic acid, arachidyl glucoside, or a mixture thereof may be included.

More specifically, the sunscreen composition according to the example includes 10 to 30 parts by weight of loofah cucumber stem sap, 200 to 250 parts by weight of glycerin, 5 to 15 parts by weight of butylene glycol, 50 to 100 parts by weight of hydrogenated polydecene, and cetyl. 50 to 80 parts by weight of ethylhexanoate, 20 to 70 parts by weight of pentaerythrityl tetraisostearate, 20 to 50 parts by weight of niacinamide, 10 to 30 parts by weight of ethylhexyl salicylate, 10 to 30 parts by weight of arachidyl alcohol. , 1 to 10 parts by weight of dimethicone, 5 to 15 parts by weight of palmitic acid, 5 to 15 parts by weight of 1,2-hexanediol, 5 to 15 parts by weight of behenyl alcohol, 5 to 15 parts by weight of stearic acid, 5 to 15 parts by weight of cetearyl alcohol, 1 to 8 parts by weight of arachidyl glucoside, 2 to 5 parts by weight of xanthan gum, 1 to 5 parts by weight of carbomer, 1 to 4 parts by weight of arginine, 1 to 2 parts by weight of star anise extract. parts, caprylyl glycol 0.5 to 2 parts by weight, fragrance 0.5 to 2 parts by weight, water-soluble collagen 0.1 to 2 parts by weight, golden extract 0.1 to 2 parts by weight, adenosine 0.1 to 2 parts by weight, propanediol 0.1 to 2 parts by weight parts, 0.1 to 2 parts by weight of glucose, 0.1 to 2 parts by weight of natto gum, 0.1 to 2 parts by weight of sodium DNA, 0.1 to 2 parts by weight of ethylhexylglycerin, and the remaining amount of purified water, but is not limited thereto.

The sunscreen patch essentially includes a sheet containing the sunscreen composition. Specifically, the sunscreen patch may be composed of a one-layer, two-layer, or three-layer sheet, and the sheet containing the sunscreen composition is a patch layer that directly contacts the skin to apply the sunscreen composition to the skin. It is characterized by being able to transmit.

Herein, the sheet may be a natural fiber sheet, a synthetic fiber sheet, or bio-cellulose. The natural fiber sheet may be a commonly used natural silkworm thread. The synthetic fiber sheet may be one or more selected from the group consisting of nylon-based, polyester-based, acrylic-based, polyvinyl alcohol-based, polyvinyl chloride-based, and polyvinylidene chloride-based, but is not limited thereto.

Biocellulose (microbial cellulose) is a substance produced by the β-1,4 bond of glucose by culturing strains and is used as a material for pharmaceutical burn treatments or cosmetic mask packs. Biocellulose is a polymer in which glucose is bonded at β-1,4, like cellulose obtained from plants, but its fiber width is much smaller than that of plant cellulose, and it has a three-dimensional network structure, so it has excellent water retention properties. When used in a cosmetic mask, it can provide a soft texture and smooth fit like a hydrogel mask, and has excellent adhesion.

The UV protection patch can be cut into a shape that is convenient for attachment to the skin. It may be provided in the shape of a commonly used mask pack, and may be provided in the form of an under-eye protection patch. Even if the adhesive area is small, it may not be easily detached even during vigorous exercise due to its excellent adhesive stability.

In particular, the sunscreen patch is completely transparent, and may be transparent or opaque before being impregnated with the sunscreen and complex skin improvement composition of the present invention, but is characterized by being transparent at least after being impregnated with the composition.

Hereinafter, the configuration of the present invention and its effects will be described in more detail through specific examples and comparative examples. However, these examples are for illustrating the present invention in more detail, and the scope of the present invention is not limited to these examples.

Example 1. Preparation of composition for UV protection and complex skin improvement

The sunscreen composition of Example 1 was prepared according to the ingredients and contents listed in Table 1 below. Raw materials Nos. 5 to 8, 10 to 13, and 16 were weighed in a beaker and mixed uniformly using HOMO MIX at a temperature of 45 to 50°C to form an oil phase. Afterwards, raw materials numbers 1 to 4, 9, 14, 15, and 17 to 31 were weighed in a beaker and mixed uniformly using HOMO MIX at 75 to 80°C. The uniformly mixed water phase was slowly added to the oil phase and emulsified for 10 minutes at 75 to 80 rpm at 5,000 rpm to obtain the composition for sunscreen and complex skin improvement of the present invention.

number Korean raw material name English raw material name Example 1 (% by weight) One Purified water Water To 100 2 Luffa cucumber stem sap Luffa Cylindrica Stem Sap 1~3 3 glycerin Glycerin 20~25 4 Butylene glycol Butylene Glycol 0.5~1.5 5 Hydrogenated polydecene Hydrogenated Polydecene 5~10 6 Cetyl Ethyl Hexanoate Cetyl Ethylhexanoate 5~8 7 Pentaerythrityl tetraisostearate Pentaerythrityl Tetraisostearate 2~7 8 Niacinamide Niacinamide 2~5 9 Ethylhexyl Salicylate Ethylhexyl Salicylate 1~3 10 Arachidyl alcohol Arachidyl Alcohol 1~3 11 dimethicone Dimethicone 0.1~1 12 Palmitic Acid Palmitic Acid 0.5~1.5 13 1,2-hexanediol 1,2-Hexanediol 0.5~1.5 14 Behenyl alcohol Behenyl Alcohol 0.5~1.5 15 Stearic Acid Stearic Acid 0.5~1.5 16 Cetearyl alcohol Cetearyl Alcohol 0.5~1.5 17 Arachidyl Glucoside Arachidyl Glucoside 0.1~0.8 18 xanthan gum Xanthan Gum 0.2~0.5 19 carbomer Carbomer 0.1~0.5 20 arginine Arginine 0.1~0.4 21 star anise extract Illicium Verum (Anise) Fruit Extract 0.1~0.2 22 caprylyl glycol Caprylyl Glycol 0.05~0.2 23 Spices Fragrance 0.05~0.2 24 Soluble collagen Soluble Collagen 0.01~0.15 25 golden extract Scutellaria Baicalensis Root Extract 0.01~0.13 26 Adenosine Adenosine 0.01~0.12 27 Propanediol Propanediol 0.01~0.1 28 glucose Glucose 0.01~0.1 29 Natto Gum Natto Gum 0.01~0.1 30 Sodium DNA Sodium DNA 0.01~0.1 31 Ethylhexylglycerin Ethylhexylglycerin 0.01~0.1

Comparative Example 1. Preparation of composition excluding loofah cucumber stem sap

The composition of Comparative Example 1 was prepared in the same manner as in Example 1, but all conditions were the same except that the luffa cucumber stem sap was not included and the same amount of purified water was added.

Example 2. Preparation of UV protection patch

The sunscreen patch of the present invention was manufactured so that the biocellulose sheet impregnated with the composition of Example 1 could be directly adhered to the skin. The UV protection patch was cut to a size that could be attached under the eyes.

Comparative Example 2. Manufacturing of UV protection patch

The UV blocking patch of Comparative Example 2 was manufactured in the same manner as Example 2, except that the composition of Comparative Example 1 was impregnated instead of the composition of Example 1.

Experimental Example 1. UV blocking effect

The UV protection factor (SPF) and UV A protection factor (PFA) of the UV protection patches of Example 2 and Comparative Example 2 were measured according to the UV protection functionality test method in the “Standards and Test Methods for Functional Cosmetics” notified by the Food and Drug Administration. The UV protection patch was attached to the Transpore tape, left for 15 minutes, and then measured with an SPF 290 analyzer. The UV protection index was summarized as the average value of three experiments, and the results are shown in Table 2 below.

Example 1 Comparative Example 2 In vitro SPF 110.2 ±6.5 78.2 ±21.5 In vitro PFA 13.5 ± 2.1 7.5 ±1.5

As shown in Table 2, it can be seen that the sunscreen patch additionally containing loofah cucumber stem sap showed excellent SPF and PFA. From this, it was confirmed that the loofah cucumber stem sap of the present invention is effective in improving the function of sunscreen.

Experimental Example 2. Transdermal absorption and penetration test

For Example 1 and Comparative Example 1, a skin permeation test was conducted under sink conditions using a Franz diffusion cell (effective area: 0.785 cm2, volume of compartment: 5 ml). Phosphate buffered saline (PBS) at pH 7.4 was used as the aqueous phase.

The prepared epidermal layer of human skin (1.5 cm The diffusion cell was filled and maintained at 32±1°C. A permeation experiment was performed by attaching the prepared Example 1 and Comparative Example 1 to the donor site. At 30 minutes, 1 hour, 2 hours, 4 hours, 6 hours, and 24 hours after the permeation experiment, 5 ml of the aqueous phase was collected and analyzed, and supplemented with fresh phosphate-buffered saline solution.

Artificial skin was purchased and used from Hans Biomed, stored at -20°C after purchase, and washed and hydrated in phosphate buffered saline for 30 minutes before use.

HPLC was used for analysis. As the analysis conditions for adenosine, a 5:94 mixture of acetonitrile and 10 mM potassium dihydrogen phosphate was used, and the column was a ZORBAX Eclipse ml/min, detection wavelength was analyzed at 260 nm, and the results are shown in Table 3.

Example 1 Example 1 Absorption amount (%) Comparative Example 1 Absorption Amount 0.5 h 0.21 0.46 1h 0.86 1.34 2h 1.65 3.57 4h 3.65 5.96 6h 5.76 11.27 24h 11.35 26.78

As the analysis conditions for niacinamide, a 75:25 mixture of 0.05M potassium dihydrogen phosphate solution (pH 7.0, 25% NaOH) and methanol was used as the mobile phase, and the column was a SunfireTM C18 reversed-phase column (Waters, 4.6 x 250mm, 5㎛). , the injection volume was 10㎕, the flow rate was 1ml/min, and the detection wavelength was analyzed at 263nm, and the results are shown in Table 4.

hour Example 1 Absorption amount (%) Comparative Example 1 Absorption amount (%) 0.5h 0.18 0.21 1h 0.32 0.64 2h 0.69 1.87 4h 1.12 3.21 6h 2.94 5.13 24h 5.02 11.90

In this way, it can be seen that the ultraviolet ray blocking patch additionally containing loofah cucumber stem sap according to the present invention effectively increases the transdermal absorption of niacinamide and adenosine, and thus it is expected to exhibit excellent wrinkle improvement and whitening effects. You can.

Experimental Example 3. Sensory evaluation of feeling of use

Existing UV-blocking patch products do not have appropriate adhesion. The adhesive force is too strong and the skin is damaged when removed, or the adhesive is not applied uniformly, so it is attached in a wrinkled state during the attachment process, leaving fine wrinkles on the skin in that wrinkled state after use.

A panel of 30 professional women aged 25 to 45 years old, targeting competitor product A along with the sunscreen patch manufactured in Example 1 and Comparative Example 1 described above, was divided into two groups and each group was given patches under the eyes with appropriate adjustments. After application, the feeling of use was evaluated according to the following evaluation criteria, including adhesion upon attachment, persistence of attachment, stickiness when detaching, refreshing sensation during the attachment period, whether fine wrinkles were formed on the skin after use, and overall satisfaction, and the results are shown in Table 5 below. Each item was evaluated with a score ranging from 1 to 5.

Example 1 Comparative Example 1 Competitor A item Adhesiveness when attached 4.7 4.0 2.4 persistence of attachment 4.6 4.3 2.9 Sticky when detached 4.5 4.1 2.1 refreshing feeling 4.7 3.5 1.9 Whether fine wrinkles appear on the skin after use 4.7 4.1 2.1 Overall satisfaction 4.6 4.1 2.8

As described above, the sunscreen patch additionally containing loofah cucumber stem sap according to the present invention was most satisfactory in terms of ease of use, and further received a high score in terms of improvement effect after use.

Experimental Example 4. Skin stability experiment

When using the patch containing the composition of Example 1, the composition adheres to the skin for a long period of time and is continuously delivered to the skin. Therefore, the present inventor requested the Korea Institute of Dermatology to evaluate the skin stability of the composition. The results were confirmed (Report No. KIDS-BBH001-DIK(5)).

Briefly, a skin patch test was conducted on 30 adult men and women aged 26 to 65 (average 50.83/standard deviation 10.01) using a Finn Chamber. The test subject's back was wiped with 70% ethanol and dried, and then the test material cut to a diameter of 7 mm was placed in a Finn Chamber with a diameter of 8 mm and then attached and fixed to the test area. The patch was attached for 24 hours, and 30 minutes, 24 hours, and 48 hours after the patch was removed, the degree of irritation was observed by a dermatologist according to the criteria of the International Contact Dermatitis Research Group (ICDRG).

As a result, no irritation was observed with the composition of the example of the present invention 30 minutes, 24 hours, and 48 hours after removal of the patch, and the average skin reactivity was 0.00, which was judged to be non-irritating according to the criteria.

Experimental Example 5. Experiment to confirm immediate skin improvement effect

Since the composition of the present invention has a composition that can produce excellent skin improvement effects in addition to the UV blocking effect, we sought to determine whether such skin improvement effects could be obtained when actually using a UV blocking patch to which the composition of the present invention was applied.

In order to confirm accurate and fair results, we commissioned the Korea Dermatological Research Institute to confirm the effects of immediate moisturizing, immediate elasticity, immediate skin clarity, immediate lifting, and immediate skin texture improvement (report number KIDS-BBG090-DIK).

Briefly, 22 adult women aged 40 to 65 years (average 54.77/standard deviation 6.49) were asked to apply the UV protection patch of Example 2, in which the composition of Example 1 was applied evenly to the cheek area, including both nasolabial folds, after washing their face. It was attached and applied for 4 hours.

Afterwards, 1) immediate moisturizing improvement evaluation by Epsilon E100, 2) immediate elasticity improvement evaluation by Ballistometer, 3) immediate skin transparency (clearness) improvement evaluation by translucency probe TLS850, 4) immediate (nasolabial fold area) evaluation by ANTERA 3D ) Lifting improvement evaluation and 5) immediate skin texture improvement evaluation (nasolabial fold area) using ANTERA 3D were conducted.

As a result, as shown in Figures 1 and 2, skin moisture increased by 125.43% immediately after one use compared to before using the test substance, confirming that immediate moisturization was improved (p<.001).

In addition, as shown in Figure 3, the CoR value indicating skin elasticity increased by 2.40% immediately after one use compared to before using the test substance, confirming that immediate elasticity was improved, and as shown in Figure 4, the Alpha value indicating skin transparency Compared to before using this test substance, it was confirmed that skin transparency (clearness) was immediately improved by decreasing by 1.35% immediately after one use.

Furthermore, as shown in Figures 5 and 6, the Depressions large value, which represents the depressed volume of the skin, was reduced by 19.79% immediately after one use compared to before using the test substance, confirming that immediate lifting (nasolabial fold area) was improved. As shown in Figures 7 and 8, the Texture small value, which indicates the roughness of the skin, decreased by 15.74% immediately after one use compared to before using the test substance, confirming that the skin texture (in the nasolabial fold area) was immediately improved.

Experimental Example 6. Experiment to confirm long-term skin improvement effect

In addition to the short-term (one-time) effect, it was additionally confirmed whether there was a long-term skin improvement effect through continuous use.

Likewise, the Korea Dermatological Research Institute was requested to confirm the effects on moisturizing, elasticity, skin transparency, lifting, and skin texture improvement (Report No. KIDS-BBG090-DIK(1-2)).

The test subject was the same as in Experimental Example 5, and after washing his face once a day for two weeks, he evenly applied the UV protection patch of Example 2, which applied the composition of Example 1, to the cheek area, including both nasolabial folds, for 4 hours. applied during.

The evaluation method for each element was measured using the same equipment as in Experimental Example 5 above.

As a result, as shown in Figure 9, skin moisture increased by 40.65% after 2 weeks of use compared to before using the test substance, confirming that moisturizing was improved.

In addition, as shown in Figure 10, the CoR value indicating skin elasticity increased by 3.49% after 2 weeks of use compared to before using the test substance, confirming that elasticity was improved, and as shown in Figure 11, the Alpha value indicating skin transparency Compared to before using this test substance, it was confirmed that skin transparency (clearness) was improved by decreasing by 1.49% after 2 weeks of use.

Furthermore, as shown in Figure 12, the Depressions large value, which represents the depressed volume of the skin, decreased by 22.27% after 2 weeks of use compared to before using the test substance, confirming that lifting (nasolabial fold area) was improved, as shown in Figure 13. As shown, the Texture small value, which indicates the roughness of the skin, decreased by 12.26% after 2 weeks of use compared to before using the test substance (nasolabial fold area), confirming that the skin texture was improved.

The various embodiments described above may be embodied in other specific forms without departing from the technical idea and essential features. Accordingly, the above detailed description should not be construed as restrictive in all respects and should be considered illustrative. The scope of the various embodiments should be determined by a reasonable interpretation of the appended claims, and all changes within the equivalent scope of the various embodiments are included in the scope of the various embodiments. In addition, claims that do not have an explicit reference relationship in the patent claims can be combined to form an embodiment or included as a new claim through amendment after filing.

Claims (5)

A UV-blocking patch containing a sheet containing a UV-blocking and complex skin-improving composition,
The sunscreen composition contains loofah cucumber stem sap, an organic sunscreen, niacinamide, and adenosine as active ingredients,
UV protection patch. According to paragraph 1,
The composition for sunscreening and complex skin improvement includes 10 to 30 parts by weight of loofah cucumber stem loofah sap, 10 to 30 parts by weight of an organic sunscreen, 20 to 50 parts by weight of niacinamide, and 0.1 to 2 parts by weight of adenosine,
UV protection patch. According to paragraph 1,
Organic sunscreens include glyceryl faba, drometrizole, digalloyl trioleate, 3-(4-methylbenzylidene)-camphor, methyl anthranilate, bis-ethylhexyloxyphenolmethoxyphenyltriazine, and diethyl. Aminohydroxybenzoylhexylbenzoate, Benzophenone-3, Benzophenone-4, Benzophenone-8, Butylmethoxydibenzoylmethane, Cinoxate, Ethylhexyltriazone, Octylmethoxycinnamate, Octocrylene, Octyldimethyl Faba, octyl salicylate, oxybenzone, cynoxate, octyl triazone, ethylhexyl methoxycinnamate, ethylhexyl salicylate, para-aminobenzoic acid, 2-phenylbenzimidazole-5-sulfonic acid, homosalate , isoamyl-p-methoxycinnamate, bisethylhexyloxyphenolmethoxyphenyltriazine, drometrizoletrisiloxane, and polysilicon-15,
UV protection patch. According to any one of claims 1 to 3,
The sheet constituting the UV protection patch is composed of biocellulose,
UV protection patch. According to clause 4,
The UV protection patch is characterized in that it is transparent,
UV protection patch.