KR20170102225A - Adhesive patch - Google Patents

Abstract

Wherein the pressure-sensitive adhesive layer comprises (a) a pressure-sensitive adhesive A: 65 to 99.5 mass% of a (meth) acrylic acid alkyl ester having an alkyl group of 8 to 12 carbon atoms, 0.5 to 8 mass% of a vinyl monomer having a functional group, (Meth) acrylic acid alkyl ester having an alkyl group of 8 to 12 carbon atoms, a vinyl monomer having a functional group in an amount of from 0.5 to 8 mass% % Of a pressure-sensitive adhesive, and 9.5 to 49.5% by weight of a vinyl monomer having a hydrophilic property, and (i) the mixing ratio of the pressure-sensitive adhesive A and the pressure-sensitive adhesive B is 15/85 to 85 / 15, and (ii) the pressure-sensitive adhesive is crosslinked.

Description

{ADHESIVE PATCH}

The present invention relates to an adhesive preparation used for the purpose of promoting the healing of wounds and hardness burns such as raising, scratching, stabbing, scorching, scratched wounds and the like, pain relief, maintenance or protection of wet environment, And particularly to an adhesive preparation suitable for first-aid bandages. Further, the present invention relates to an adhesive preparation useful as a transdermal preparation capable of orally administering a pressure-sensitive adhesive tape or a drug for medical use.

The adhesive material generally has a layer structure including a support layer made of a plastic film, a woven fabric, a nonwoven fabric, a knitted fabric, paper or the like, and a pressure-sensitive adhesive layer formed on at least one surface of the support layer. Further, in the case where a separator layer is disposed to protect the surface of the pressure-sensitive adhesive layer and, for example, the support layer is very thin, the support layer has a layer structure in which a carrier layer is provided.

When a woven fabric, a nonwoven fabric, a woven fabric, paper, or the like is used as a support for the adhesive material, the waterproofing property is excellent although the moisture permeability is excellent. Therefore, when the adhesive material is used in a place where water is used, .

On the other hand, when a film is used for the support to maintain the waterproof property, there is a problem that the moisture permeability is lowered by the film, and the skin becomes swollen and the oscillation easily occurs. Therefore, a pressure-sensitive adhesive excellent in waterproofness, moisture permeability and adhesiveness is required.

In general, as a pressure-sensitive adhesive constituting the pressure-sensitive adhesive layer in an adhesive preparation, rubber, acrylic, silicone and urethane-based pressure-sensitive adhesives are known, and among them, excellent adhesiveness and heat resistance, weather resistance, Acrylic pressure sensitive adhesives are frequently used.

In the case of an acrylic pressure-sensitive adhesive, a pressure-sensitive adhesive made of a copolymer having a large proportion of hydrophilic monomers has high moisture permeability but low adhesive strength, and a high ratio of acrylic acid alkyl ester (hydrophobic monomer) In order to improve the adhesive force and the moisture permeability of the acrylic pressure-sensitive adhesive, a copolymer in which various kinds of hydrophilic monomers and copolymerizable monomers for changing the kind of the (meth) acrylic acid ester monomer as its main component in the acrylic pressure- Acrylic pressure sensitive adhesives having many properties have been produced. However, even when a high copolymer is predicted for both the adhesive force and the water vapor permeability, both the adhesive force and the moisture permeability become intermediate to each other, and a pressure sensitive adhesive sufficiently satisfying the adhesive force and the moisture permeability is rarely obtained. Therefore, it has been considered to use a mixture of acrylic pressure-sensitive adhesives having different properties.

Patent Document 1 discloses a pressure-sensitive adhesive layer which comprises a copolymer obtained by copolymerizing (A) a monomer containing a carboxyl group or a hydroxyl group and (meth) acrylic acid ester as essential components, and (B) (Meth) acrylic acid ester as essential components, and (C) an organic liquid component which is compatible with the components (A) and (B) And a cross-linked pressure-sensitive adhesive is disclosed. Patent Document 2 discloses a copolymer comprising a component (A) comprising a copolymer having a carboxyl group-containing monomer and a (meth) acrylate ester as monomer units, a monomer having a pyrrolidone group-containing monomer and a (meth) A crosslinking agent which is crosslinked by reaction with at least one crosslinking agent selected from the group consisting of metal chelate compounds, metal oxides and metal hydroxides is disclosed as the component (A) have. However, both of these documents are effective in solubility of the drug in addition to adhesiveness, so that the moisture permeability in the case of using a waterproof film as a support is not considered.

Patent Document 3 discloses a pressure-sensitive adhesive composition comprising (A) a pressure-sensitive adhesive polymer A comprising a methacrylic acid 2-acetoacetoxyethyl ester and a copolymer comprising other vinyl monomers as constituent components, and (B) Discloses the use of a mixture of two kinds of pressure-sensitive adhesives, that is, a pressure-sensitive adhesive polymer B, which comprises a copolymer of an alkyl (meth) acrylate and other vinyl monomers as constituents and a copolymer different from the pressure-sensitive adhesive polymer A. Patent Document 4 discloses a medical non-crosslinked pressure-sensitive adhesive comprising a pressure-sensitive adhesive polymer A having a weight average molecular weight of 500,000 to 1,000,000, an adhesive polymer B having a weight average molecular weight of 1,000,000 to 1,500,000, and a liquid plasticizer, Vinyl-2-pyrrolidone with an alkyl (meth) acrylate ester, and the adhesive polymer B is a polymer obtained by homopolymerizing an alkyl (meth) acrylate or an alkyl (meth) Non-crosslinked pressure-sensitive adhesive which is a polymer obtained by copolymerizing a comonomer other than N-vinyl-2-pyrrolidone. However, in both documents, stickiness and skin irritation are considered, but a liquid plasticizer is used in order to improve compatibility in the mixing of the pressure-sensitive adhesives, and waterproofness, moisture permeability and adhesiveness are not considered.

As described above, when two kinds of acrylic pressure-sensitive adhesives having different compositions are mixed, the compatibility becomes poor, and it is often necessary to add a plasticizer. In addition, when a film having increased water resistance is used as a support, an adhesive material having improved moisture permeability and adhesiveness and excellent compatibility of two types of acrylic pressure-sensitive adhesives is required.

Japanese Patent Application Laid-Open No. 2000-44904 Japanese Laid-Open Patent Publication No. 2006-241179 International Publication No. 2006/64747 Japanese Patent Application Laid-Open No. 2005-314251

A problem to be solved by the present invention is to provide a pressure-sensitive adhesive which is mixed with two kinds of acrylic pressure-sensitive adhesives and which does not cause swelling or oscillation of the skin even when a film material is used as a support for imparting waterproofness, And it is an object of the present invention to provide an adhesive preparation having both moisture permeability and adhesiveness.

Means for Solving the Problems As a result of intensive studies on solving the above problems, the present inventors have found that when a film material is used as a support by blending a specific two kinds of acrylic pressure sensitive adhesives having good compatibility as a pressure- The inventors have come to think about whether or not a sticky material having both waterproof property, flexibility and adhesiveness can be made.

The acrylic pressure-sensitive adhesive generally comprises a (meth) acrylic acid alkyl ester as a monomer unit. The inventors of the present invention have found that when the content of the (meth) acrylic acid alkyl ester having an alkyl group of 8 to 12 carbon atoms is more than a certain level, the adhesive agent easily absorbs the sebum component secreted from the skin, , And a (meth) acrylic acid alkyl ester having an alkyl group having 8 to 12 carbon atoms as a main component.

That is, a pressure-sensitive adhesive having both waterproofness and moisture-permeability as well as required adhesiveness can be obtained by using two types of acrylic pressure-sensitive adhesives whose major component is an alkyl (meth) acrylate ester having an alkyl group having 8 to 12 carbon atoms as a mixed pressure- It was conceived that it was not.

The present inventors have found that acrylic pressure-sensitive adhesives, which are (meth) acrylic acid alkyl esters whose main component is an alkyl (meth) acrylate having a carbon number of 8 to 12, have a hydrophobic property, and therefore an acrylic pressure- By further crosslinking, it has come to be thought that it is not a pressure-sensitive adhesive having both waterproofness and moisture-permeability as well as adhesiveness.

For this purpose, the present inventors have found that, based on a pressure-sensitive adhesive in which a vinyl monomer having a functional group capable of copolymerizing with a (meth) acrylic acid alkyl ester for crosslinking in a small amount as required for crosslinking is added to a (meth) acrylic acid alkyl ester, Of the second component. In this case, it should be considered that the compatibility of the two acrylic pressure-sensitive adhesives becomes appropriate in the mixing. However, use of a plasticizer is undesirable because it deteriorates the properties of the pressure-sensitive adhesive.

The inventors of the present invention have found that, in consideration of compatibility, it is appropriate to use a hydrophilic vinyl monomer as a third component in order to obtain an acrylic pressure sensitive adhesive having hydrophilic properties. That is, the inventors of the present invention have found out a mixed pressure-sensitive adhesive of an acrylic pressure-sensitive adhesive having different properties of pressure-sensitive adhesive A (with no third component) and pressure-sensitive adhesive B (with third component) depending on the presence or absence of the third component, , Waterproof property, water vapor permeability and adhesive property.

That is, according to the present invention, there is provided an adhesive preparation comprising (1) a support layer and a pressure-sensitive adhesive layer,

(a) Pressure-sensitive adhesive A: 65 to 99.5% by mass of a (meth) acrylic acid alkyl ester having an alkyl group of 8 to 12 carbon atoms as an essential component, 0.5 to 8 mass% of a vinyl monomer having a functional group copolymerizable with the (meth) acrylic acid alkyl ester (Meth) acrylic acid alkyl ester or a vinyl monomer thereof in a total amount of 100% by mass of the total amount of the monomers as the other components, and the vinyl monomer having hydrophilicity capable of copolymerizing with the (meth) acrylic acid alkyl ester And 0 to 34.5% by mass of a vinyl monomer which does not contain a vinyl monomer, and

(meth) acrylic acid alkyl ester having an alkyl group having 8 to 12 carbon atoms as essential components in an amount of 50 to 90% by mass of a (meth) acrylic acid alkyl ester having a total of 100 mass% (Meth) acrylate and a vinyl monomer different from the vinyl monomer, and having a hydrophilic vinyl monomer copolymerizable with the (meth) acrylic acid alkyl ester in an amount of 9.5 to 49.5 mass% (I) the mixing ratio of the pressure-sensitive adhesive A and the pressure-sensitive adhesive B (pressure-sensitive adhesive A / pressure-sensitive adhesive B) is such that the total mass of the pressure-sensitive adhesive A and the pressure- , And (ii) the pressure-sensitive adhesive is crosslinked when the amount of the pressure-sensitive adhesive is 100 parts by mass or more and 15/85 to 85/15 (mass ratio) Is provided.

According to the present invention, (2) the adhesive material of (1), wherein the pressure-sensitive adhesive layer is crosslinked by a crosslinking agent, is provided.

According to the present invention, (3) the adhesive material of (1), wherein the functional group is a carboxyl group or a hydroxyl group, is provided.

(4) According to the present invention, (4) the adhesive material of any one of (1) to (3), wherein the pressure-sensitive adhesive layer contains no plasticizer which is liquid at room temperature, is provided.

Further, according to the present invention, (5) the support is provided with any one of the above-mentioned (1) to (4) including a film.

(6) According to the present invention, (6) the adhesive sheet of any one of the above (1) to (4), wherein the support is a laminate of a film and a fabric, is provided.

(7) The adhesive sheet according to any one of (1) to (6) above, which has a moisture permeability of 300 g / m 2 ∙ 24 h or more, is provided.

(8) When the mixing ratio of the pressure-sensitive adhesive A and the pressure-sensitive adhesive B (pressure-sensitive adhesive A / pressure-sensitive adhesive B) is 100 parts by mass as the total mass of the pressure-sensitive adhesive A and the pressure-sensitive adhesive B, (1) to (7), wherein the weight ratio of the adhesive layer to the adhesive layer is in the range of 1: 1 to 1: 1.

(9) The pressure-sensitive adhesive composition according to the above item (1), wherein the difference between the SP values of the solubility parameter of the (meth) acrylic acid alkyl ester having an alkyl group of 8 to 12 carbon atoms, which is the main constituent of the pressure- To (8) are provided.

According to the present invention, (10) a sticking material of any one of (1) to (9), which is a first-aid adhesive tape, is provided.

According to the present invention, it is possible to provide a pressure-sensitive adhesive of a sticking material by using a mixed pressure-sensitive adhesive comprising a hydrophobic acrylic pressure-sensitive adhesive having compatibility and a hydrophilic acrylic pressure-sensitive adhesive without the need for a plasticizer, It is possible to provide an adhesive preparation having both waterproofness and moisture permeability as well as adhesiveness without causing swelling or oscillation of the skin.

These pastes are useful as first-aid plasters, as medical adhesive tape or as percutaneous absorption preparations.

The adhesive preparation of the present invention is basically an adhesive preparation comprising a support layer and a pressure-sensitive adhesive layer.

1. Support layer

The support layer of the adhesive patch of the present invention can be a film, fabric, knitted fabric, nonwoven fabric, and the like. In particular, the support layer is waterproof and can be brought into close contact with the skin, It is preferable to include a film which is flexible enough to hold the film and which can suppress the generation of skin rashes and the like after a long time.

The film to be used as the support layer of the present invention can be obtained by using, for example, polyethylene, polypropylene, polyethylene terephthalate (hereinafter also referred to as "PET"), polybutylene terephthalate, polyethylene naphthalate, polystyrene, , Cotton, acetate, rayon, rayon / polyethylene terephthalate composite, polyacrylonitrile, polyvinyl alcohol, acrylic polyurethane, polyester polyurethane, polyether polyurethane, styrene-isoprene-styrene copolymer, styrene- A single layer or a laminate of a film composed of a butadiene-styrene copolymer, a styrene-ethylene-propylene-styrene copolymer, a styrene-butadiene rubber, an ethylene-vinyl acetate copolymer and a cellophane. In order to suppress the generation of skin rashes, the support layer is preferably a layer having a water vapor permeability of 1,000 g / m < 2 > (measured at a temperature of 40 DEG C and a relative humidity of 90%) specified in JIS Z 0208 Hour, and particularly preferably 2,000 g / m < 2 > 24 hours or more.

In the present invention, an elastomer film is also preferably used as a support layer having water resistance and flexibility and moisture-permeability. Examples of the elastomer forming the elastomer film include a polyurethane elastomer, a 1,2-polybutadiene thermoplastic elastomer, a polystyrene thermoplastic elastomer, a polyolefin thermoplastic elastomer, and a mixture of two or more thereof. Among these elastomers, a polyurethane elastomer film is preferable.

As the support layer of the present invention, it is preferable to use a fabric laminated with a fabric to further impart flexibility and hygroscopicity to the above water-resistant film. The fabric is preferably a nonwoven fabric made of a polyurethane fiber in that it is a nonwoven fabric, a woven fabric and a knitted fabric made of polyester fibers, polyacrylic fibers and polyurethane fibers, woven fabrics and knitted fabrics in addition to natural fibers. The lamination of the film and the fabric can be either a film or a fabric on the side to which the adhesive is applied.

(Thickness of the support layer)

The thickness of the support layer provided by the adhesive sheet of the present invention is in the range of 10 to 50 m in the case of the film only, but may be 20 to 250 m in the case of the laminate composed of the film and the foil, Mu m. In the case of a laminate composed of a film and a fabric, the thickness of the film is 2 to 20 占 퐉, preferably 3 to 10 占 퐉. When the thickness of the support layer is too thin, the strength of the support layer becomes insufficient, and when the adhesive preparation is attached to the skin or the adhesive preparation is removed from the skin, the support layer may be cut off . In addition, if the thickness of the support layer is too large, the thickness of the adhesive preparation becomes large. As a result, the adhesive preparation is not closely adhered along the surface of the skin having fine irregularities such as skin grooves and the like, It is easy to grow.

(additive)

The film forming the support layer is preferably a plastic film having excellent transparency in that it is easy to make the adhesive layer invisible in the adhesive portion, that is, to make the color tone of the skin visible through the adhesive portion. The film forming the layer may contain various additives such as colorants such as pigments and dyes, stabilizers, ultraviolet absorbers, lubricants and the like as desired. The content of these additives may be appropriately selected in accordance with the type of the additive, and it is usually 0.001 to 30 parts by mass, preferably 0.01 to 25 parts by mass, more preferably 0.001 to 30 parts by mass based on 100 parts by mass of the resin material constituting the film , It is often in the range of 0.1 to 20 parts by mass.

[Emboss processing]

In order to improve the feel, slidability, appearance, and the like of the adhesive preparation when the adhesive preparation is applied to the skin surface of a person, the back surface of the support layer constituting the adhesive preparation (the surface of the support layer opposite to the pressure- It is preferable to form minute concavities and convexities on the surface of the substrate. In other words, the adhesive layer may be embossed so that the surface of the support layer opposite to the pressure-sensitive adhesive layer side is embossed. By embossing, the coefficient of dynamic friction of the surface of the support layer can be reduced to less than 1.0. In addition, when minute unevenness is formed on the surface of the carrier layer by embossing and a support layer is formed on the minute uneven surface, minute unevenness is formed on the surface (back surface) of the support layer formed from the elastomer film It can be transferred.

The support layer may be subjected to surface treatment such as sandblasting or corona treatment on one side or both sides for the purpose of improving an embossability with a pressure-sensitive adhesive. It is also possible to form concavities and convexities on one side or both sides of the support layer by a method other than sandblasting, in order to facilitate removal of the adhesive preparation from the packaging material.

2. Adhesive layer

The adhesive sheet of the present invention is a pressure-sensitive adhesive in which the adhesive agent for forming a pressure-sensitive adhesive layer is a mixture of the following two acrylic pressure-sensitive adhesives.

(a) Pressure-sensitive adhesive A:

(Meth) acrylic acid alkyl ester having an alkyl group with a carbon number of 8 to 12 in an amount of from 65 to 99.5 mass% and a vinyl monomer having a functional group copolymerizable with the (meth) acrylic acid alkyl ester in an amount of from 0.5 to 8 mass% (Meth) acrylic acid alkyl ester or a vinyl monomer thereof in the range of from 0.1 to 50% by weight, more preferably 100% by weight or less of the total of the monomers. The vinyl monomer having no hydrophilicity and being copolymerizable with the alkyl (meth) By mass of a copolymer.

(b) Pressure-sensitive adhesive B:

(Meth) acrylic acid alkyl ester having an alkyl group having 8 to 12 carbon atoms as an essential component in an amount of 50 to 90% by mass, and a vinyl monomer having a functional group copolymerizable with the (meth) acrylic acid alkyl ester (Meth) acrylic acid alkyl ester or a vinyl monomer different from the (meth) acrylic acid alkyl ester or the vinyl monomer, and 9.5 to 49.5% by mass of a hydrophilic vinyl monomer copolymerizable with the alkyl (meth) acrylate Containing acrylic pressure-sensitive adhesive.

When the total mass of the pressure-sensitive adhesive (A) and the pressure-sensitive adhesive (B) is 100 parts by mass, the blended pressure-sensitive adhesive is preferably 15/85 to 85/15 (mass ratio) (Mass ratio), more preferably 35/65 to 65/35, and further, the pressure-sensitive adhesive A and the pressure-sensitive adhesive B are crosslinked.

The pressure-sensitive adhesive A is a two-component system or a three-component system. The method for determining the component ratio is to determine the amount of the pressure-sensitive adhesive A and then to adjust the components of the essential components within a predetermined range, I will. The pressure-sensitive adhesive B is a three-component system, and the component ratio is determined so that the total amount is 100% by mass.

(1) Adhesive A

Adhesive A is hydrophobic.

The acrylic pressure-sensitive adhesive A used in the adhesive preparation of the present invention contains 65 to 99.5% by mass, preferably 75 to 99.3% by mass, of a (meth) acrylic acid alkyl ester having an alkyl group having 8 to 12 carbon atoms as an essential component Is 0.5 to 8% by mass, preferably 0.7 to 6% by mass, more preferably 0.9 to 5% by mass, and the balance of (meth) acrylic acid alkyl ester is 80 to 98% (Meth) acrylic acid alkyl ester or a vinyl monomer thereof in an amount of 100% by mass of the total of the monomers as the component (A), the vinyl monomer which is copolymerizable with the (meth) acrylic acid alkyl ester, 0 to 34.5 mass%, preferably 0 to 24.3 mass%, and more preferably 0 to 19.1 mass%.

(1-1) a (meth) acrylic acid alkyl ester having an alkyl group having 8 to 12 carbon atoms

Examples of the (meth) acrylic acid alkyl ester having an alkyl group having 8 to 12 carbon atoms as essential components in the pressure-sensitive adhesive A include n-octyl (meth) acrylate, 2-ethylhexyl (meth) acrylate, isooctyl (Meth) acrylate, n-decyl (meth) acrylate, isodecyl (meth) acrylate, and lauryl (meth) acrylate. Among these (meth) acrylic acid alkyl esters, acrylic acid alkyl esters having an alkyl group having 8 to 9 carbon atoms such as 2-ethylhexyl acrylate and isononyl acrylate are particularly preferable. These (meth) acrylic acid alkyl esters may be used either individually or in combination of two or more.

(1-2) A vinyl monomer having a functional group copolymerizable with the (meth) acrylic acid alkyl ester

The functional group functions as a functional group for crosslinking the pressure-sensitive adhesive A and the pressure-sensitive adhesive B, and the functional group includes a carboxyl group, a hydroxyl group, an amino group, an amide group and an epoxy group, and among them, a carboxyl group and a hydroxyl group are preferable. Examples of the carboxyl group-containing monomer include (meth) acrylic acid, itaconic acid and maleic acid. Examples of the hydroxyl group-containing monomer include hydroxylmethyl (meth) acrylate, hydroxyethyl (meth) acrylate, And (meth) acrylic acid monoesters of polyalkylene glycols such as diethylene glycol monoester of (meth) acrylic acid. Examples of the monomer having an amino group include aminoethyl (meth) acrylate, amide group-containing monomers include (meth) acrylamide, and epoxy group-containing monomers include glycidyl acrylate. These may be used in combination of two or more. Preferably acrylic acid, polyethylene glycol monomethacrylate.

(1-3) a vinyl monomer copolymerizable with (meth) acrylic acid alkyl ester, having no hydrophilicity

The vinyl monomer is a monomer different from the vinyl monomers (1-1) and (1-2), and has no hydrophilic property.

That is, the vinyl monomer having no hydrophilicity is excluded from the alkyl (meth) acrylate (1-1) and the vinyl monomer having a functional group used as the vinyl monomer in the above (1-2).

That is, in the pressure-sensitive adhesive A, the (meth) acrylic acid alkyl ester or the vinyl monomer having a functional group and the vinyl monomer having no hydrophilic property are not overlapped.

Examples of the vinyl monomers different from the vinyl monomers (1-1) and (1-2) include (meth) acrylic acid alkyl esters and vinyl esters having an alkyl group having 1 to 6 carbon atoms.

That is, the (meth) acrylic acid alkyl ester having an alkyl group having 1 to 6 carbon atoms is preferably selected from the group consisting of methyl (meth) acrylate, ethyl (meth) acrylate, n-butyl (meth) acrylate, isobutyl -Butyl (meth) acrylate, and n-hexyl (meth) acrylate.

(Meth) acrylic esters having a saturated carbon ring such as a cyclohexyl group, vinyl esters such as vinyl acetate and vinyl propionate, cyano group-containing vinyl monomers (unsaturated nitrile) such as acrylonitrile and methacrylonitrile, Vinyl aromatic compounds, acrylamide, and the like. These may be used in combination of two or more. Preferred is vinyl acetate.

(1-4) Examples of such a pressure-sensitive adhesive A include specifically a pressure-sensitive adhesive containing a copolymer comprising 96% by weight of isononyl acrylate and 4% by weight of acrylic acid, a pressure-sensitive adhesive containing 98% by weight of acrylic acid, And 2% by mass of a copolymer, and a pressure-sensitive adhesive containing a copolymer of 85% 2-ethylhexyl acrylate, 4% acrylic acid and 11% vinyl acetate by mass.

(2) Adhesive B

The pressure-sensitive adhesive B is hydrophilic.

The acrylic pressure-sensitive adhesive B used in the adhesive application of the present invention preferably contains 50 to 90% by mass of a (meth) acrylic acid alkyl ester having an alkyl group having 8 to 12 carbon atoms as an essential component in the range of 100% by mass of the total of the monomers, Preferably 0.5 to 8 mass%, more preferably 0.7 to 6 mass%, still more preferably 51 to 88 mass%, and still more preferably 52 to 86 mass%, of a vinyl monomer having a functional group copolymerizable with the alkyl (meth) (Meth) acrylic acid alkyl ester or a vinyl monomer thereof, which is copolymerizable with the (meth) acrylic acid alkyl ester, a hydrophilic vinyl monomer having hydrophilicity in an amount of 9.5 to 49.5% by mass, Preferably 11.3 to 48.3% by mass, and more preferably 13.1 to 47.1% by mass, based on 100 parts by mass of the acrylic pressure-sensitive adhesive All.

(2-1) Pressure-Sensitive Adhesive The (meth) acrylic acid alkyl ester having an alkyl group having 8 to 12 carbon atoms in B is selected from the above (1-1).

(2-2) The vinyl monomer having a functional group copolymerizable with the (meth) acrylic acid alkyl ester of the pressure-sensitive adhesive B is selected from the above (1-2).

(2-3) Hydrophilic vinyl monomers copolymerizable with (meth) acrylic acid alkyl ester

As a third component, a vinyl monomer having hydrophilicity is used to generate hydrophilic properties.

The vinyl monomer is a vinyl monomer different from the (meth) acrylic acid alkyl ester of the above (2-1) or the vinyl monomer of the above (2-2), and has hydrophilic properties.

That is, the vinyl monomer having hydrophilicity can be obtained by reacting the (meth) acrylic acid alkyl ester of the above (2-1) or the vinyl monomer having the functional group used as the vinyl monomer having the functional group described in the above (2-2) Are excluded.

That is, in the pressure-sensitive adhesive B, the (meth) acrylic acid alkyl ester or the vinyl monomer having a functional group and the vinyl monomer having a hydrophilic property are not overlapped.

As the vinyl monomer having hydrophilicity, a vinyl monomer having an alkoxy group is usually used.

Examples of the vinyl monomer having an alkoxy group include 2-methoxyethyl (meth) acrylate, 2-ethoxyethyl (meth) acrylate, 2-propoxyethyl (meth) acrylate, 2-butoxyethyl ) 2-ethoxymethyl acrylate. Further, (meth) acrylic esters of alkoxy (poly) alkylene glycols such as methoxyethylene glycol esters of methoxyethylene glycol and methoxy diethylene glycol may be mentioned. Methacryloxypropyl acrylate, 2-methoxyethyl acrylate, and methoxypolyethylene glycol acrylate.

(2-4) Examples of such a pressure-sensitive adhesive B include pressure-sensitive adhesives containing a copolymer composed of 68% by weight of acrylic acid, 2% by weight of acrylic acid and 30% by weight of 2-methoxyethyl acrylate, Neil 83 _{mass%, CH 2 = CHCOO- (CH} 2 CH 2 O) 9 H 1% by _{weight, CH 2 = CHCOO- (CH 2} CH 2 O) 9 CH 3 a pressure-sensitive adhesive containing a copolymer consisting of 16% by weight .

(Preparation of acrylic copolymer)

The acrylic copolymer constituting the pressure-sensitive adhesive A and the pressure-sensitive adhesive B forming the pressure-sensitive adhesive layer of the adhesive sheet of the present invention can be produced by radical polymerization. The solution polymerization method, the emulsion polymerization method, the bulk polymerization method, and the like are known as the polymerization method of the acrylic copolymer. The solution polymerization method is preferable because the pressure-sensitive adhesive layer provided by the adhesive material of the present invention tends to obtain good adhesive properties . Examples of the polymerization initiator for obtaining the acrylic copolymer include organic peroxides such as benzoyl peroxide and lauroyl peroxide; Azo type initiators such as azobisisobutyronitrile; And the like. Concretely, 0.1 to 3 parts by mass of a radical polymerization initiator is added to 100 parts by mass of the entire monomers consisting of the above-mentioned b-1), b-2) and b-3 forming the acrylic copolymer, And the mixture is stirred at a temperature of about 40 to 90 DEG C for 30 minutes to 30 hours to copolymerize. In the solution polymerization method, ethyl acetate, acetone, toluene, or a mixture thereof is generally used as a solvent.

The weight average molecular weight of the acrylic copolymer constituting the pressure-sensitive adhesive A and the pressure-sensitive adhesive B is usually in the range of 100,000 to 1,500,000, preferably 300,000 to 1,000,000, and more preferably 450,000 to 650,000. By setting the weight average molecular weight of the acrylic copolymer within the above range, the cohesiveness, adhesive strength, mixing workability with other components, affinity with other components and the like in the pressure-sensitive adhesive layer can be balanced. The weight average molecular weight of the acrylic copolymer is a value calculated as a standard polystyrene conversion value by a gel permeation chromatography (GPC) method.

(Compatibility)

The pressure-sensitive adhesive layer of the present invention is such that the pressure-sensitive adhesive A and the pressure-sensitive adhesive B are mixed at a ratio of 15/85 to 85/15 (mass ratio) when the total mass of the pressure-sensitive adhesive A and the pressure-sensitive adhesive B is 100 parts by mass, Lt; / RTI > The pressure-sensitive adhesive A has hydrophobicity, and the pressure-sensitive adhesive B has hydrophilicity. It is important that the pressure-sensitive adhesive has a compatibility with each other so that the pressure-sensitive adhesive is integrated as a pressure-sensitive adhesive layer. In the present invention, (Meth) acrylic acid alkyl ester having an alkyl group having 1 to 12 carbon atoms is the same or is not the same, the difference in SP value of the solubility parameter is preferably 0.50 or less. A preferable mixing ratio of the pressure-sensitive adhesive A and the pressure-sensitive adhesive B is 25/75 to 75/25 (mass ratio), and more preferably 35/65 to 65/35 (mass ratio).

(Crosslinking and crosslinking agent)

In the present invention, the pressure-sensitive adhesive A and the pressure-sensitive adhesive B may be crosslinked without a crosslinking agent by a mixing treatment, but it is also preferred that they are crosslinked by a crosslinking agent. Examples of the crosslinking agent include polyfunctional isocyanate compounds (tolylene diisocyanate , 4'-diphenylmethane diisocyanate (MDI), hexamethylene diisocyanate, xylylene diisocyanate, meta xylylene diisocyanate, 1,5-naphthalene diisocyanate, hydrogenated diphenylmethane diisocyanate, hydrogenated tolylene diisocyanate, Xylene diisocyanate and isophorone diisocyanate], polyfunctional epoxy compounds and acetylacetone metal salts. Commercially available products include, for example, Colonate (registered trademark) HL manufactured by Nippon Polyurethane Industry Co., Ltd., Colonate L , Colonate EH, manufactured by Mitsubishi Gas Chemical Co., Ltd. TETRAD-X (registered trademark), TETRAD-C (registered trademark), Nasem (registered trademark) aluminum and the like. The content of the crosslinking agent is preferably 0.01 to 1 part by mass, more preferably 0.03 to 0.5 part by mass, particularly preferably 0.04 to 0.1 part by mass, relative to 100 parts by mass of the total amount of the acrylic copolymer in the pressure-sensitive adhesives A and B, Mass part. The cross-linking agent may be used alone or in combination of two or more kinds, or two or more kinds of the cross-linking agent may not be added at the same time, or may be added before or during coating of the pressure-sensitive adhesive for forming the pressure-sensitive adhesive layer.

(additive)

The pressure-sensitive adhesive layer of the present invention may contain various additives, if necessary, in addition to the pressure-sensitive adhesives A and B and the cross-linking agent. The additive may include additives commonly used in a pressure-sensitive adhesive forming a pressure-sensitive adhesive layer of a patch such as a drug, a filler, an antioxidant (an antioxidant, an antiseptic), a colorant, a flavor, a tackifier and a plasticizer. For example, a tackifier may be added to adjust the tack property of the tackifier. Examples of the tackifier include tackifier resins such as terpene, terpene phenol, coumarone indene, styrene, rosin, xylene, phenol, and petroleum.

(Plasticizer)

The pressure-sensitive adhesive A and the pressure-sensitive adhesive B for forming the pressure-sensitive adhesive layer in the present invention have compatibility with each other and are further subjected to a crosslinking treatment, so that the plasticizer contained in the pressure- You do not have to. Examples of such plasticizers include polyhydric alcohols (glycerin, sorbitol, propylene glycol, 1,3-butylene glycol, 1,3-tetramethylene glycol, polyethylene glycol and the like); Phenols (thymol, saffrol, isosaprol, augenol, isoionol, etc.); Higher alcohols (benzyl alcohol, oleyl alcohol, cetyl alcohol, stearyl alcohol, cetostearyl alcohol, octyldodecanol, etc.); Ester type surfactants (sorbitan sesquioleate, polyoxyethylene hydrogenated castor oil, stearic acid polyoxyl, etc.); Fatty acid esters (myristic acid isopropyl, octyldodecyl myristate, oleyl oleate, diethyl phthalate, dibutyl phthalate and the like); Organic acids (such as lactic acid, citric acid, tartaric acid, maleic acid, malic acid); A plasticizer which is liquid at room temperature is known.

In the present invention, it is preferable not to include a plasticizer which is liquid at room temperature. In the present invention, " not containing a plasticizer which is liquid at room temperature " means a content which does not affect the adhesive property by containing a plasticizer which is a liquid at room temperature, and usually 100 parts by mass of an acrylic pressure- , It is usually allowed to contain not more than 2 parts by mass, preferably not more than 0.5 parts by mass.

(Drugs, etc.)

The pressure-sensitive adhesive layer in the present invention may contain various kinds of drugs usually contained in the pressure-sensitive adhesive in the adhesive preparation. Such drugs include, but are not limited to, pyridoxine dicaprylylate, dipotassium glycyrrhizinate, pyridoxine dipyrmidate, glycyrrhizin acid, diphenhydramine hydrochloride, fenugreek extract, glycyrrhetinyl stearate, lysozyme chloride, aminocaproic acid, An anti-inflammatory agent such as an electric sperm extract, a peony extract, a ginseng extract, a ginseng root extract, a ginseng extract, a ginseng extract, an allantoin and an arnica extract; Antimicrobial agents such as chiconine, hinokitiol, cedrol, benzalkonium chloride, benzethonium chloride, photoresist 201 and adipic acid; Sebum secretion inhibitors such as estradiol, vitamin B2, vitamin B6, royal jelly extract, and riboflavin; Absorbent porous powder such as porous nylon powder and porous cellulose powder; Sebum absorbents such as kaolin, talc, clay and zinc oxide; Keratolytic agents such as salicylic acid, sulfur, bentonite, and cyclodextrin; Antioxidants (antiseptics) such as dibutyl hydroxytoluene, tocopherol acetate, ascorbic acid, benzoic acids, parabens, benzalkonium chloride and benzethonium chloride; Skin roughness improving agents such as Arnica montana extract, licorice extract, retinol, di potassium glycyrrhizinate, peony extract, sage leaf extract, loquat leaf extract, and rosemary extract; Antioxidants such as vitamins and butylhydroxytoluene; Also, various analgesic anti-inflammatory agents; Antihistamines; Corticosteroids; Moisturizer; Vitamins; Spices ; Beauty ingredients; And the like.

When the adhesive preparation of the present invention is used as an oral absorption preparation, a medicament which is absorbed through the skin and is required for the treatment of the disease is added according to the purpose. For example, examples of analgesic agents include steroidal analgesics, nonsteroidal anti-inflammatory analgesics, narcotic analgesics, and local anesthetics. Other medicines include mental stabilizers, antidepressants, insomnia improving drugs, antihypertensive agents, and the like.

In addition, the pressure-sensitive adhesive for forming the pressure-sensitive adhesive layer in the present invention may contain fillers such as calcium carbonate, magnesium carbonate, silicate, zinc oxide, titanium oxide, magnesium sulfate and calcium sulfate, if necessary; ≪ / RTI >

The content of the above-mentioned drug or filler varies depending on the type of the drug or the filler, and preferably 0.001 to 10 mass%, particularly 0.01 to 2 mass%, based on 100 mass% of the total mass of the pressure- .

(Thickness of the pressure-sensitive adhesive layer)

The thickness of the pressure-sensitive adhesive layer in the adhesive preparation of the present invention is in the range of 10 to 200 占 퐉, preferably in the range of 15 to 150 占 퐉, more preferably in the range of 20 to 100 占 퐉.

3. Separator layer

The adhesive sheet of the present invention is usually provided with a separator layer adjacent to the pressure-sensitive adhesive layer in order to protect the pressure-sensitive adhesive layer until the pressure-sensitive adhesive layer is attached to the skin, in addition to the support layer and the pressure- .

The separator layer in the present invention is not particularly limited, and in the technical field of the adhesive sheet, those used generally as release paper, release film, release paper, release film, release liner and the like can be used. Specifically, for example, a polyethylene terephthalate film whose surface has been subjected to a silicone treatment, a laminate of polyethylene and a paper whose surface is subjected to a silicone treatment, and the like can be given. The separator layer may be made of two or more sheets of the same or different thickness to protect the pressure-sensitive adhesive layer. In addition, the separator layer may be formed with an incision to improve handleability (i.e., peelability from the pressure-sensitive adhesive layer), or it may be formed to have an area larger than that of the adhesive preparation, and the grip portion may be formed on the periphery. The separator layer may be provided with irregularities by sandblasting or the like on the surface opposite to the pressure-sensitive adhesive layer of the separator layer or on the surface opposite to the pressure-sensitive adhesive layer, for the purpose of improving handling properties and printing suitability. Further, the separator layer may be formed as one large sheet, and a plurality of combinations of the pressure-sensitive adhesive layer, the support layer and the carrier layer may be arranged thereon. In this case, the separator layer is shared by a plurality of adhesive sheets.

The thickness of the separator layer can be appropriately set and is not particularly limited, but is usually 20 占 퐉 or more, preferably 40 占 퐉 or more, and the upper limit is about 500 占 퐉.

4. Carrier layer

Usually, in the case where the support layer is thin, it is preferable that the adhesive layer is an adhesive layer provided by laminating a carrier layer, a support layer, a pressure-sensitive adhesive layer and a separator layer in this order. By providing the carrier layer adjacent to the support layer, the adhesive preparation can improve the handleability of the adhesive preparation and the sticking property to the skin, and can easily form the support layer in the method of producing the adhesive preparation. That is, when the adhesive preparation is affixed to the skin, wrinkles are formed in the support layer or the adhesive preparation is bent to bond the adhesive layers together. However, since the adhesive preparation has the carrier layer adjacent to the support layer, It is possible to prevent such a problem. The thickness of the carrier layer can be suitably set and is not particularly limited, but is usually 20 占 퐉 or more, preferably 40 占 퐉, and the upper limit is about 500 占 퐉.

The carrier layer can be formed using a film made of various kinds of thermoplastic resins, and examples thereof include polyurethane, polyethylene, polypropylene, ionomer, polyamide, polyvinyl chloride, polyvinylidene chloride, ethylene vinyl acetate copolymer, Thermoplastic polyester, polytetrafluoroethylene, or the like can be used. In addition, a laminate of these films and paper can be used.

The carrier layer can be easily peeled from the support layer at the time of use, that is, when the adhesive preparation is applied to the skin. Therefore, the carrier layer and the support layer are formed so as to be peelable by thermal compression bonding, adhesion, or the like. In order to adjust the peeling force between the carrier layer and the support layer, a pressure-sensitive adhesive, a liquid plasticizer, a releasing agent, and the like may be coated on the side of the carrier layer opposite to the support layer.

5. Adhesive member

The adhesive sheet of the present invention has a support and a pressure-sensitive adhesive layer for imparting water resistance, and has high moisture permeability and high adhesive force as an adhesive sheet. The water vapor permeability is preferably 300 g / m < 2 > .24 h or more, and the probe tack is preferably 1.0 to 4.0 N / 5 mm phi.

(The shape of the adhesive material)

The adhesive preparation of the present invention is an adhesive preparation comprising a support layer and a pressure sensitive adhesive layer and is not particularly limited in shape as long as it has the above-mentioned properties, and can be used as a first layer, a pressure sensitive adhesive tape, For example, in the case of using an adhesive tape, it may be in the form of a roll. If it is a first-aid bandage or a transdermal absorption preparation, it may be circular, elliptical, or a form depending on the purpose of use.

(Moisture permeability)

The adhesive preparation of the present invention preferably has a water vapor transmission rate of 300 g / m 2 24 h or more, preferably 600 g / m 2 24 h or more, more preferably 650 g / m 2 24 h or more, still more preferably 700 g / ? 24 h or more, particularly preferably 750 g / m 2 24 h or more. The upper limit is 1500 g / m 2 24 h, preferably 1,070 g / m 2 24 h. By having a large moisture permeability, it is possible to prevent perspiration or stiffness when the adhesive preparation is affixed to the skin. The moisture permeability is measured under condition B (temperature 40 ° C, relative humidity 90%) prescribed in JIS Z 0208.

(Probe tip)

The adhesive sheet of the present invention preferably has a probe pitch of 1.0 to 4.0 N / 5 mmφ, more preferably 1.95 to 3.70 N / 5 mmφ, further preferably 1.96 to 3.60 N / 5 mmφ, Particularly preferably 1.97 to 3.57 N / 5 m ?. If the probe tack is too small, the adhesive may fall off during the attachment. If the probe tack is too large, the user may feel resistance and pain when peeling off the skin surface after the adhesive preparation is applied.

(Manufacturing method of sticking material)

The adhesive sheet of the present invention is an adhesive sheet comprising a support layer and a pressure-sensitive adhesive layer,

(a) Pressure-sensitive adhesive A: 65 to 99.5% by mass of a (meth) acrylic acid alkyl ester having an alkyl group having 8 to 12 carbon atoms as an essential component, and 0.5 to 8 mass% of a monomer having a functional group copolymerizable with the (meth) acrylic acid alkyl ester (Meth) acrylic acid alkyl ester or a vinyl monomer thereof in an amount of 100% by mass of the total amount of the monomers as the other components, and an alkoxy group copolymerizable with the (meth) acrylic acid alkyl ester And 0 to 34.5% by mass of a vinyl monomer not containing a vinyl monomer, and

(meth) acrylic acid alkyl ester having an alkyl group having 8 to 12 carbon atoms as an essential component in an amount of 50 to 90 mass% in the total amount of 100 mass% of the (meth) acrylic acid alkyl ester and A vinyl monomer having an alkoxy group copolymerizable with the (meth) acrylic acid alkyl ester as a vinyl monomer different from the (meth) acrylic acid alkyl ester or the vinyl monomer is used in an amount of from 0.5 to 8 mass% By mass of an acrylic pressure-sensitive adhesive containing a copolymer

(I) the mixing ratio of the pressure-sensitive adhesive A and the pressure-sensitive adhesive B is 15/85 to 85/15 (mass ratio) when the total mass of the pressure-sensitive adhesive A and the pressure-sensitive adhesive B is 100 parts by mass, , And (ii) the adhesive agent is crosslinked, the production method thereof is not limited as long as the adhesive agent can be obtained. The adhesive sheet of the present invention can be produced as a sheet-like laminate, or can be produced as a laminate on a roll. A conventional patch manufacturing method can be employed, and a hot melt method, a calender method, a melting method, or the like, which is a general method for producing a patch, can be employed. Among them, a drag method is preferable. The dissolution method is a method in which a necessary component is dissolved in a solvent and spread on a support, and thereafter the solvent is evaporated and then kneaded with the support, followed by cutting into a suitable shape to obtain a patch.

As one manufacturing method of the patch of the present invention, two kinds of pressure sensitive adhesives of acrylic pressure sensitive adhesives and a crosslinking agent are added, uniformly stirred and mixed, and the pressure sensitive adhesive is applied onto a process paper (process paper) coated with a silicone release agent, A solution or an emulsion is applied to form a pressure-sensitive adhesive layer, and then the pressure-sensitive adhesive layer is integrated with a support including a film. The coating method is not particularly limited, and for example, a solution of a pressure-sensitive adhesive containing each component can be coated by using a general-purpose coating machine such as a knife coater, a comma coater, or a reverse coater. The obtained patch is rolled up in a roll to obtain a roll-like patch, and cut to a predetermined shape and size such as an ellipse, a circle, a square and a rectangle depending on the use.

(Use of sticky material)

The adhesive sheet of the present invention can be used as a general first-aid adhesive sheet in which a carrier layer and a separator layer are adhered to each other as required and shaped according to a use site. Alternatively, it can be used directly as a pressure sensitive adhesive tape for medical use, or it can be a percutaneous absorption preparation to which a specific drug is added.

Example

EXAMPLES Hereinafter, the present invention will be described in detail with reference to Examples and Comparative Examples, but the present invention is not limited to these Examples. The properties and physical properties of each layer provided by the adhesive preparation and the adhesive sheet of the present invention are as follows.

(thickness)

The thicknesses of the support layer, the pressure-sensitive adhesive layer and the adhesive material were measured using a dialsikness gauge (unit: μm, average value of n = 3).

(Moisture permeability)

The moisture permeability of the adhesive sheet was measured under the B condition (temperature: 40 캜, relative humidity: 90%) prescribed in JIS Z 0208 (unit: g / m 2 ∙ 24 h, n = 3 average value).

(Probe tip)

The probe of the pressure-sensitive adhesive layer was measured using a probe tester manufactured by Nichiban Co., Ltd. according to the probe test described in JIS Z 0237 (1996 edition) as a reference, and a circumferential probe having a diameter of 5 mm was cut perpendicularly (Unit: N / 5 mmφ, average value of n = 3).

(Practical evaluation)

As a practical evaluation of the adhesive material, five subjects of an adult male and female were wiped off the water after bathing, and then the adhesive agent was applied to the second joints of the fingers and attached for 12 hours, followed by bathing to evaluate the adhesiveness after bathing. Thereafter, after 24 hours from the attachment, "adhesion after 24 hours attaching" was evaluated, and then the adhesive preparation was peeled to evaluate "skin attachment". Each of the five subjects was evaluated according to the following criteria 1 to 5, and the average value was rounded off and evaluated according to the following criteria. The comprehensive evaluation was evaluated by the present inventors based on the results of the characteristic evaluation and the practical evaluation.

≪ Adherence after Bathing >

5: The whole surface was well attached.

4: The circumference was slightly peeled or curled.

3: About 1/3 of it was peeled or curled.

2: More than half were peeled or curled.

1: Drop out

A: Average of 4.0 or higher

B: Average value is 3.5 to 3.9

C: Average value less than 3.4

<Adhesiveness after 24 hours attaching>

5: The whole surface was well attached.

4: The circumference was slightly peeled or curled.

3: About 1/3 of it was peeled or curled.

2: More than half were peeled or curled.

1: Drop out

A: Average value is 3.6 or more

B: Average value is 3.1 to 3.5

C: Average value less than 3.0

<The boogie of the skin>

5: No bookkeeping

4: Poor but no problem

3: Problems with pouring

2: There is a lot of problems with pouring

1: Blistering due to excessive swelling

A: Average of 4.0 or higher

B: Average value is 3.5 to 3.9

C: Average value less than 3.4

<Overall evaluation>

AA: Overall excellent

A: Overall excellent.

C: I have a problem in general.

[Analysis of compatibility of pressure-sensitive adhesive A and pressure-sensitive adhesive B]

Pressure-sensitive adhesive A1: 0.05 part of an epoxy crosslinking agent (TETRAD-X, manufactured by Mitsubishi Gas Chemical Company) was added to an acrylic pressure-sensitive adhesive of 2-ethylhexyl acrylate / vinyl acetate / acrylic acid (mass ratio 85/11/4) copolymer and crosslinked.

Adhesive B1: 0.05 part of an epoxy-based cross-linking agent (TETRAD-X) manufactured by Mitsubishi Gas Chemical Company) was added to an acrylic pressure-sensitive adhesive of an isonyl acrylate / 2-methoxyethyl acrylate / acrylic acid copolymer (mass ratio 68/30/2) .

Mixed pressure-sensitive adhesive C1: Pressure-sensitive adhesive A: (acrylic pressure-sensitive adhesive of 2-ethylhexyl acrylate / vinyl acetate / acrylic acid (85/11/4 by mass ratio) copolymer) and pressure-sensitive adhesive B (: isononyl acrylate / 2-methoxyethyl acrylate / (TETRAD-X manufactured by Mitsubishi Gas Chemical Company, Ltd.) in an amount of 0.05 part by mass based on the total of 100 parts by mass of the acrylic pressure-sensitive adhesive of the acrylic copolymer (mass ratio 68/30/2).

The dynamic viscoelasticity measurement of the pressure-sensitive adhesive A1, the pressure-sensitive adhesive B1 and the pressure-sensitive adhesive C1 was carried out to determine the temperature dependence of the respective tan delta (loss tangent), the temperature dependency of the storage elastic modulus (G ') and the temperature dependency of the loss elastic modulus The solubility parameter SP values of 2-ethylhexyl acrylate and isonyl acrylate were 8.36 and 8.38, respectively, and the difference was within the range of 0.50.

(result)

The glass transition temperature (Tg) of the pressure-sensitive adhesive A1 was -33.2 占 폚 and the glass transition temperature of the pressure-sensitive adhesive B1 was -19.4 占 폚 due to the temperature dependence of tan? (Loss tangent) , And the glass transition temperature of the mixed pressure-sensitive adhesive C1 was only one peak within the range of -29.3 to -27.6 ° C. Therefore, the glass transition temperature of the pressure-sensitive adhesive mixture C1 was close to -26.3 DEG C, which is the midpoint between the glass transition temperatures of the pressure-sensitive adhesive A1 and the pressure-sensitive adhesive B1, respectively.

The temperature-dependent change of the storage elastic modulus (G ') and the loss elastic modulus (G ") of the mixed pressure-sensitive adhesive C1 was located between the pressure-sensitive adhesive A1 and the pressure-sensitive adhesive B1 and exhibited the same change.

[Examples 1 to 7 and Comparative Examples 1 to 4]

(Thickness of the support layer: 170 mu m, thickness of the pressure-sensitive adhesive layer: 40 mu m) on which the pressure-sensitive adhesive layer of the mixed pressure-sensitive adhesive C1 was formed was obtained on a support obtained by laminating a polyurethane nonwoven fabric on a polyurethane film. The influence of the mixture ratio of the pressure-sensitive adhesive A1 and the pressure-sensitive adhesive B1 as the adhesive agent was examined in the same manner by changing the mixing ratio of the pressure-sensitive adhesive A1 and the pressure-sensitive adhesive B1. Practical evaluation and characterization of each adhesive material were carried out. The results are shown in Table 1.

[Example 8]

An adhesive agent layer (thickness: 40 占 퐉) was formed on the polyurethane elastomer film (thickness: 30 占 퐉) with the mixed pressure-sensitive adhesive C1. 50 parts by mass of the pressure-sensitive adhesive A1 and 50 parts by mass of the pressure-sensitive adhesive B1 were subjected to a practical evaluation and a characteristic evaluation. The results are shown in Table 1.

[Review]

From Table 1, in the case of Examples 1 to 7, in which the support is a film / non-woven fabric, the pressure-sensitive adhesive A alone has low moisture permeability of 594 g / m 2 ∙ 24 h, It was found that the moisture permeability exceeded 650 g / m &lt; 2 &gt; The best practical evaluation was obtained when the mixing ratio of the pressure-sensitive adhesive A and the pressure-sensitive adhesive B was 35/65 to 65/35 (mass ratio).

However, when the pressure-sensitive adhesive B is increased to more than 85 parts by mass in 100 parts by mass of the blended pressure-sensitive adhesive, the blending ratio of the pressure-sensitive adhesive A to the pressure-sensitive adhesive B (pressure-sensitive adhesive A / pressure-sensitive adhesive B) is 15/85 to 85/15 (mass ratio) It was found that the practical evaluation was inferior.

In the case of Example 8 in which the support was a film, although the moisture permeability was lowered because the support was a film, adhesion to the skin was good in the evaluation of practicality. This is because the water does not enter from the side.

Compared with the examples, in Comparative Examples 1 to 4, there was a problem in that there was an evaluation of C and a comprehensive evaluation of C in practical evaluation.

Industrial availability

The adhesive sheet of the present invention is applied to skin or the like and is preferably used for medical use, for example, in fields such as medical hygiene and external use. Specifically, it can be used for a bandage, a medical adhesive tape, an adhesive bandage, a dressing material, a surgical tape for surgical operation, a percutaneous absorption preparation, and the like.

INDUSTRIAL APPLICABILITY The present invention provides a pressure-sensitive adhesive comprising a hydrophobic acrylic pressure-sensitive adhesive and a hydrophilic acrylic pressure-sensitive adhesive, wherein the pressure-sensitive adhesive layer of the pressure-sensitive adhesive does not have swelling or oscillation, It is possible to provide an adhesive preparation having both adhesiveness and adhesiveness, so that it is highly industrially applicable as an adhesive preparation suitable for medical adhesive tape or emergency bandage. Especially, it is suitable for first aid bandage.

Claims (10)

A support layer and a pressure-sensitive adhesive layer, wherein the pressure-
(a) Pressure-sensitive adhesive A: 65 to 99.5% by mass of a (meth) acrylic acid alkyl ester having an alkyl group of 8 to 12 carbon atoms as an essential component, 0.5 to 8% by mass of a vinyl monomer having a functional group copolymerizable with the (meth) (Meth) acrylic acid alkyl ester or a vinyl monomer thereof in an amount of 100% by mass or more based on 100% by mass of the total amount of the monomers as the remaining component. The vinyl monomer, which is copolymerizable with the alkyl (meth) And 0 to 34.5% by mass of a vinyl monomer not containing a vinyl monomer, and
(meth) acrylic acid alkyl ester having an alkyl group having 8 to 12 carbon atoms as essential components in an amount of 50 to 90% by mass of a (meth) acrylic acid alkyl ester having a total of 100 mass% , 0.5 to 8 mass% of a vinyl monomer having a functional group, a vinyl monomer different from the (meth) acrylic acid alkyl ester or the vinyl monomer and having hydrophilicity capable of copolymerizing with the (meth) acrylic acid alkyl ester, 9.5 to 49.5 % By mass of an acrylic pressure-sensitive adhesive containing a copolymer,
Here, the functional group is a carboxyl group, a hydroxyl group, an amino group, an amide group or an epoxy group,
The vinyl monomer having no hydrophilicity may be a (meth) acrylic acid alkyl ester having an acryl group having 1 to 6 carbon atoms, a (meth) acrylic acid ester having a saturated carbon ring, a vinyl ester, a cyano group-containing vinyl monomer, Amide, and
The hydrophilic vinyl monomer is an alkoxy group-containing vinyl monomer,
(Mass ratio) when the total mass of the pressure-sensitive adhesive A and the pressure-sensitive adhesive B is 100 parts by mass, (i) the mixing ratio of the pressure-sensitive adhesive A and the pressure-sensitive adhesive B (pressure-sensitive adhesive A / And (ii) the pressure-sensitive adhesive is crosslinked. The method according to claim 1,
Wherein the pressure-sensitive adhesive layer is crosslinked by a crosslinking agent. The method according to claim 1,
Wherein the functional group is a carboxyl group or a hydroxyl group. 4. The method according to any one of claims 1 to 3,
Wherein the pressure-sensitive adhesive layer comprises a pressure-sensitive adhesive for forming a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive does not contain a plasticizer which is liquid at room temperature. 5. The method according to any one of claims 1 to 4,
Wherein the support layer comprises a film. 6. The method according to any one of claims 1 to 5,
Wherein the support layer is a laminate of a film and a fabric. 7. The method according to any one of claims 1 to 6,
Adhesive members with a moisture permeability of 300 g / m 2 ∙ 24 h or more. 8. The method according to any one of claims 1 to 7,
Wherein the mixing ratio (pressure-sensitive adhesive A / pressure-sensitive adhesive B) of the pressure-sensitive adhesive A and the pressure-sensitive adhesive B is 35/65 to 65/35 (mass ratio) when the total mass of the pressure-sensitive adhesive A and the pressure-sensitive adhesive B is 100 parts by mass. 9. The method according to any one of claims 1 to 8,
Wherein the difference between the solubility parameter (SP) of the alkyl (meth) acrylate having an alkyl group of 8 to 12 carbon atoms in the pressure-sensitive adhesive A and the alkyl (meth) acrylate having an alkyl group of 8 to 12 carbon atoms in the pressure- 10. The method according to any one of claims 1 to 9,
Admission materials for first aid bandages.