KR20170096065A - 항종양 알칼로이드를 이용한 병용요법 - Google Patents

항종양 알칼로이드를 이용한 병용요법 Download PDF

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KR20170096065A
KR20170096065A KR1020177022535A KR20177022535A KR20170096065A KR 20170096065 A KR20170096065 A KR 20170096065A KR 1020177022535 A KR1020177022535 A KR 1020177022535A KR 20177022535 A KR20177022535 A KR 20177022535A KR 20170096065 A KR20170096065 A KR 20170096065A
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combination
cancer
pharmaceutically acceptable
acceptable salt
showed
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Korean (ko)
Inventor
빅토리아 모네오 오카나
게마 산타마리아 누네즈
루이스 프란시스코 가르시아 페르난데즈
카를로스 마리아 갈마리니
마리아 호세 구일렌 나바로
빠블로 마누엘 아비레스 마린
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파르마 마르 에스.에이.
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Publication of KR20170096065A publication Critical patent/KR20170096065A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020177022535A 2010-11-12 2011-11-11 항종양 알칼로이드를 이용한 병용요법 Ceased KR20170096065A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10382300.1 2010-11-12
EP10382300 2010-11-12
PCT/EP2011/069976 WO2012062920A1 (en) 2010-11-12 2011-11-11 Combination therapy with an antitumor alkaloid

Related Parent Applications (1)

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KR1020167019709A Division KR20160088956A (ko) 2010-11-12 2011-11-11 항종양 알칼로이드를 이용한 병용요법

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KR1020177022535A Ceased KR20170096065A (ko) 2010-11-12 2011-11-11 항종양 알칼로이드를 이용한 병용요법
KR1020137015020A Active KR101716804B1 (ko) 2010-11-12 2011-11-11 항종양 알칼로이드를 이용한 병용요법
KR1020217011747A Active KR102452022B1 (ko) 2010-11-12 2011-11-11 항종양 알칼로이드를 이용한 병용요법
KR1020167019709A Ceased KR20160088956A (ko) 2010-11-12 2011-11-11 항종양 알칼로이드를 이용한 병용요법
KR1020177013349A Withdrawn KR20170057472A (ko) 2010-11-12 2011-11-11 항종양 알칼로이드를 이용한 병용요법
KR1020197033700A Active KR102301175B1 (ko) 2010-11-12 2011-11-11 항종양 알칼로이드를 이용한 병용요법
KR1020177031575A Active KR102247982B1 (ko) 2010-11-12 2011-11-11 항종양 알칼로이드를 이용한 병용요법
KR1020177013350A Withdrawn KR20170058454A (ko) 2010-11-12 2011-11-11 항종양 알칼로이드를 이용한 병용요법
KR1020177022534A Ceased KR20170096224A (ko) 2010-11-12 2011-11-11 항종양 알칼로이드를 이용한 병용요법

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KR1020137015020A Active KR101716804B1 (ko) 2010-11-12 2011-11-11 항종양 알칼로이드를 이용한 병용요법
KR1020217011747A Active KR102452022B1 (ko) 2010-11-12 2011-11-11 항종양 알칼로이드를 이용한 병용요법
KR1020167019709A Ceased KR20160088956A (ko) 2010-11-12 2011-11-11 항종양 알칼로이드를 이용한 병용요법
KR1020177013349A Withdrawn KR20170057472A (ko) 2010-11-12 2011-11-11 항종양 알칼로이드를 이용한 병용요법
KR1020197033700A Active KR102301175B1 (ko) 2010-11-12 2011-11-11 항종양 알칼로이드를 이용한 병용요법
KR1020177031575A Active KR102247982B1 (ko) 2010-11-12 2011-11-11 항종양 알칼로이드를 이용한 병용요법
KR1020177013350A Withdrawn KR20170058454A (ko) 2010-11-12 2011-11-11 항종양 알칼로이드를 이용한 병용요법
KR1020177022534A Ceased KR20170096224A (ko) 2010-11-12 2011-11-11 항종양 알칼로이드를 이용한 병용요법

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US (5) US20130266666A1 (OSRAM)
EP (6) EP2786754B1 (OSRAM)
JP (4) JP6382516B2 (OSRAM)
KR (9) KR20170096065A (OSRAM)
CN (3) CN103282037B (OSRAM)
AU (4) AU2011328004C1 (OSRAM)
BR (4) BR122017028566B1 (OSRAM)
CA (4) CA2995033C (OSRAM)
CY (4) CY1117466T1 (OSRAM)
DK (4) DK2786756T3 (OSRAM)
ES (4) ES2569180T3 (OSRAM)
HK (1) HK1202422A1 (OSRAM)
HR (4) HRP20160361T1 (OSRAM)
HU (4) HUE042801T2 (OSRAM)
LT (3) LT2786753T (OSRAM)
ME (3) ME02395B (OSRAM)
PL (4) PL2637663T3 (OSRAM)
PT (3) PT2786756T (OSRAM)
RS (4) RS60236B1 (OSRAM)
RU (4) RU2605335C2 (OSRAM)
SI (4) SI2786754T1 (OSRAM)
SM (4) SMT201900190T1 (OSRAM)
TR (2) TR201903859T4 (OSRAM)
WO (1) WO2012062920A1 (OSRAM)

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Publication number Priority date Publication date Assignee Title
US8491927B2 (en) * 2009-12-02 2013-07-23 Nimble Epitech, Llc Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor
HUE042801T2 (hu) * 2010-11-12 2019-07-29 Pharma Mar Sa Kombinációs terápia mitózisgátlóval
EP2983674A4 (en) 2013-04-08 2017-05-10 Dennis M. Brown Therapeutic benefit of suboptimally administered chemical compounds
KR101588949B1 (ko) * 2014-03-13 2016-01-29 아주대학교산학협력단 플루나리진을 유효성분으로 함유하는 뇌암에 대한 항암 활성 보조제
CA2975223C (en) * 2015-01-30 2021-08-24 Glax Llc Compositions and methods for monitoring, diagnosis, prognosis, detection, and treatment of cancer
CA3008960C (en) * 2016-01-11 2024-07-02 Syndevrx, Inc. TREATMENT OF TUMORS INDUCED BY METABOLIC DYSFUNCTION
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
WO2020087077A1 (en) 2018-10-26 2020-04-30 Syndevrx,Inc. Biomarkers of metap2 inhibitors and applications thereof
EP4025217A1 (en) * 2019-09-03 2022-07-13 Pharma Mar, S.A. Lurbinectedin in the treatment of malignant mesothelioma
KR20210049403A (ko) * 2019-10-25 2021-05-06 연세대학교 산학협력단 암의 예방 또는 치료용 조성물
WO2021228414A1 (en) * 2020-05-14 2021-11-18 Pharma Mar, S.A. Methods of treating small cell lung cancer with lurbinectedin formulations
MA56827B2 (fr) * 2019-11-21 2023-09-27 Pharma Mar Sa Procédés de traitement du cancer du poumon à petites cellules avec des formulations de lurbinectédine
PH12022551216A1 (en) * 2019-11-21 2023-07-17 Pharma Mar Sa Methods of treating small cell lung cancer with lurbinectedin formulations
CN111298122B (zh) * 2019-12-04 2021-12-21 哈尔滨商业大学 用于治疗小细胞肺癌的药物组合物及其应用
US12441707B2 (en) 2019-12-30 2025-10-14 Tyra Biosciences, Inc. Indazole compounds
CN113491771A (zh) * 2020-03-18 2021-10-12 苏州大学 小分子化合物在制备glut5摄取转运果糖的抑制剂中的应用
EP4141110A4 (en) 2020-04-24 2025-04-09 Sf Biotech Laboratuvar Danismanlik Anonim Sirketi Method for producing particles of bacteriophages of the genus levivirus
EP4176880A4 (en) * 2020-07-01 2024-07-03 New Cancer Cure - Bio Co., Ltd. PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF CANCER COMPRISING A 3-KETOACYL-COA THIOLASE INHIBITOR AND AN INHIBITOR OF CARNITINE ACYLCARNITINE TRANSPORTERS
CN118576601A (zh) * 2020-10-23 2024-09-03 和记黄埔医药（上海）有限公司 一种药物组合产品在制备用于治疗结肠癌的药物中的用途
CN112870194B (zh) * 2021-01-06 2022-06-21 广州医科大学附属肿瘤医院 治疗肝癌的组合物及其应用
CN115957188A (zh) * 2021-06-17 2023-04-14 中国医学科学院医药生物技术研究所 米铂脂质体在抗耐药性肿瘤的应用
CN115246846B (zh) * 2021-11-19 2024-10-01 江苏慧聚药业股份有限公司 卢比替定新晶型及其制备
WO2023165603A1 (en) * 2022-03-03 2023-09-07 Zai Lab (Shanghai) Co., Ltd. Dna-pk inhibitor and combination use thereof
WO2024188978A1 (en) * 2023-03-10 2024-09-19 Pharma Mar, S.A. Lurbinectedin as mcl-1 inhibitor and combinations thereof for use in treating cancer
EP4563149A1 (en) * 2023-11-30 2025-06-04 Pharma Mar, S.A. Lurbinectedin, ecubectedin and a related compound for use in the treatment of skin cancers
WO2025228597A1 (en) 2024-04-30 2025-11-06 Pharma Mar, S.A. Combination of compound ia and a topoisomerase i inhibitor in the treatment of cancer
WO2025228596A1 (en) 2024-04-30 2025-11-06 Pharma Mar, S.A. Combination of pm14 and a topoisomerase i inhibitor in the treatment of cancer

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59225189A (ja) 1983-06-03 1984-12-18 Shionogi & Co Ltd キノナミン誘導体およびその製造法
JPS6084288A (ja) 1983-10-13 1985-05-13 Shionogi & Co Ltd シアノキノナミンアセテ−ト類およびその製造法
AU589282B2 (en) 1986-06-09 1989-10-05 University Of Illinois Ecteinascidins 729, 743, 745, 759a, 759b and 770
US5256663A (en) 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5089273A (en) 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5149804A (en) 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
US5478932A (en) 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US5721362A (en) 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US5985876A (en) 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
DE69936845T2 (de) 1998-04-06 2008-05-08 The Board Of Trustees Of The University Of Illinois, Urbana Halbsynthetische ectein-ascidine
EP1077698B1 (en) 1998-05-11 2005-03-02 Pharma Mar, S.A. Metabolites of ecteinascidin 743
US6124292A (en) 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
US7311924B2 (en) * 1999-04-01 2007-12-25 Hana Biosciences, Inc. Compositions and methods for treating cancer
AR035842A1 (es) * 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
EP1254140A4 (en) 2000-01-19 2003-03-12 Univ Columbia SAFRAMYCIN-ECTEINASCIDIN SERIES COMPOUNDS, USES AND SYNTHESIS
ATE299146T1 (de) 2000-04-12 2005-07-15 Pharma Mar Sa Ecteinaschidin derivate mit antikrebs wirkung
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
KR100718946B1 (ko) * 2000-11-06 2007-05-16 파르마 마르, 에스.에이. 효과적인 항종양 치료
SE0102232L (sv) 2001-06-25 2003-02-06 Anoto Ab Förfarande och anordning i ett digitalt kommunikationssystem
GB0119243D0 (en) * 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
PL375713A1 (en) 2002-08-19 2005-12-12 Pfizer Products Inc. Combination therapy for hyperproliferative diseases
MXPA05004133A (es) 2002-10-18 2005-10-05 Pharma Mar Sau Nuevos compuestos antitumorales.
FR2856688B1 (fr) 2003-06-25 2008-05-30 Sod Conseils Rech Applic PRODUIT COMPRENANT AU MOINS UN INHIBITEUR DE PHOSPHATASE CDc25 EN ASSOCIATION AVEC AU MOINS UN AUTRE AGENT ANTI-CANCEREUX
US7393277B2 (en) * 2003-08-25 2008-07-01 Igt Horseshoe payline system and games using that system
SI1689404T1 (sl) * 2003-11-13 2009-02-28 Pharma Mar Sau Kombinacija et-743 s 5-fluorouracil pro zdravili za zdravljenje raka
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
CN1897949A (zh) * 2003-11-14 2007-01-17 马尔药品公司 包含使用et－743和紫杉醇来治疗癌症的联合疗法
MXPA06013902A (es) * 2004-05-28 2007-01-26 Pfizer Prod Inc Procedimiento para tratar el crecimiento de celulas anormal.
NZ554761A (en) 2004-10-29 2010-01-29 Pharma Mar Sa Formulations comprising ecteinascidin and a disaccharide
JP5345323B2 (ja) * 2004-12-15 2013-11-20 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ 癌を処置するための治療剤の組合せ
TW200744603A (en) * 2005-08-22 2007-12-16 Chugai Pharmaceutical Co Ltd Novel anticancer concomitant drug
WO2007101235A2 (en) * 2006-02-28 2007-09-07 Pharma Mar, S.A. Improved antitumoral treatments
WO2009140675A2 (en) * 2008-05-16 2009-11-19 Pharma Mar, S.A. Combination therapy with an antitumor alkaloid
HUE042801T2 (hu) * 2010-11-12 2019-07-29 Pharma Mar Sa Kombinációs terápia mitózisgátlóval

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