KR20170078329A

KR20170078329A - Manufacturing method of menstrual pain relief patch thereof

Info

Publication number: KR20170078329A
Application number: KR1020150188721A
Authority: KR
Inventors: 김정현; 신민철; 문정민; 김성빈
Original assignee: 주식회사 케이티에이치아시아; 주식회사 메디셀바이오
Priority date: 2015-12-29
Filing date: 2015-12-29
Publication date: 2017-07-07
Also published as: KR101768707B1

Abstract

The present invention relates to a skin temperature-responsive functional hydrogel which is applied to a patch to help alleviate the pain of a menstrual cramp when the patch is attached to the abdomen of a woman, has no adverse effects on the skin even when the patch is attached for a long time, The present invention relates to a patch for relieving menstrual pain using a skin temperature-responsive functional hydrogel, which makes it possible to help relieve pain of a menstrual cure which lasts for a long time due to continuous dissolution of the skin,
The composition is prepared by preparing a patch for alleviating menstrual pain comprising a urethane film, a nonwoven fabric, a hydrogel, a functional material, a moisturizing agent and a release film, wherein the hydrogel is made of polyacrylic acid, glycerin, water, sodium hydroxide Agar, Polysorbate 60, and the functional material is a mixture of a saccharide bark extract, a cinnamon fruit extract, a chamomile flower extract, a mother plant extract, and an auxiliary agent. Wherein the mixing ratio of the hydrogel, the functional material, and the humectant is 80 to 90% by weight of the hydrogel, 8 to 14% by weight of the functional material, And 2 to 6% by weight of an additive.

Description

Technical Field [0001] The present invention relates to a patch for relieving menstrual pain using a skin temperature responsive functional hydrogel and a manufacturing method thereof,

The present invention relates to a hydrogel which, when adhered around the abdomen of a woman, causes a change in state to a sol state while slowly dissolving in response to the temperature around the abdomen to be absorbed by the skin around the abdomen, A functional hydrogel is prepared by mixing a functional material having an effect and a method for producing a patch for relieving menstrual pain using the functional hydrogel.

The term "repetitive" refers to a repetitive, convulsive abdominal pain occurring during the menstruation period. A case in which the lesion in the pelvis can not be identified is referred to as a "primary" The case is referred to as a secondary episode. In the case of severe menstrual cramps, daily life and activities such as school life and work life or other important activities can be hindered, and their management is very important for normal activities and life of women.

It is caused by excessive production of prostaglandin (PG) F2α or increased ratio of PGF2α: PGE2 in the endometrium of menstrual cramps. Through this, irregular uterine contractions and excessive uterine contractions can induce uterine ischemia, causing pain, and can also cause symptoms such as nausea, vomiting and diarrhea.

The role of prostaglandin as a cause of menstrual cramps has already been reported in several studies, with the administration of nonsteroidal anti-inflammatory drugs (NSAIDS) to reduce the symptoms of menstrual cramps, supporting prostaglandin as a major cause of menstrual cramps.

Menstrual pain generally does not occur until menstrual cycles are established after menarche. The duration of menstrual cycle after menarche is 18 ~ 45% within 2 years, 45 ~ 70% between 2 and 4 years and 80% between 4 and 5 years.

On the other hand, the menstrual cramps are accompanied by convulsive abdominal pain and may be accompanied by nausea, vomiting, diarrhea, headache, dizziness, back pain, etc. These pain usually occurs several hours before menstruation and lasts for one to three days.

According to the results of a study on women in Korea, 77 ~ 94% of patients complained of menstrual cramps. Of these, 47% were experiencing menorrhagia each month, 53.2% were experiencing severe menorrhagia, and 46% of women in the manufacturing industry were restricted from activities due to menorrhagia. In other countries, prevalence of prevalence of menses was high (60 ~ 93%) and 42% experienced severe degree of menstrual cramps. 10 to 50 percent of female students reported that they suffered from daily life activities such as school life due to their menstrual cramps and estimated the damage caused by menstrual cramps in the case of industry workers. As a result, 600 million hours of lost work and $ 2 billion Productivity loss.

As mentioned above, the menstrual cramps are high frequency of occurrence and are serious because they are pointed out as the most common reasons of periodic absence and absenteeism. However, there is a tendency to accept that women should suffer from fatalism, In fact.

This is due to the fact that the menstrual cramps themselves are not a males but a gender only, and they are not malignant and they can recover to normal after a few days without treatment.

However, most of the research results on the method of solving the menstrual cramps were answered by the patient himself or herself taking the painkillers at any time, or just taking care of them. Therefore, it is an essential task to improve the quality of life of women and to find effective ways to deal with menstrual cramps at socioeconomic level. So far, intervention methods for relieving menstrual cramps include warm therapy, aromatherapy, surgery, TENS (transcutaneous nerve stimulation), saliva, foot reflexology, acupressure, and magnetic field use.

Korean Patent Laid-Open No. 10-2010-0113075 (October 20, 2010) Korean Patent Laid-Open No. 10-2012-0090123 (Aug. 17, 2012) Korean Patent Laid-Open No. 10-2012-0115765 (Oct. 19, 2012)

The present invention relates to a hydrogel which slowly dissolves in the abdomen when adhered to the abdomen of a woman with a menstrual cramp, which is absorbed by the skin, and contains the extract of Saccharomyces bark bark extract, cinnamon fruit extract, chamomile flower extract, And the functional hydrogel is applied to a patch attached to the periphery of the abdomen, thereby alleviating the menstrual pain.

According to an aspect of the present invention, there is provided a method of manufacturing a nonwoven fabric, comprising the steps of: applying an adhesive (15) to one surface of a urethane film (10); Preparing a functional hydrogel (25) by mixing a functional material having an effect of alleviating menstrual pain on the hydrogel and an auxiliary additive having crosslinking and moisturizing effect; Applying the functional hydrogel to the surface of the nonwoven fabric 20 or one side surface of the release film 30, and then bringing the functional hydrogel into close contact with the nonwoven fabric and the release film to form a patch sheet; Aging and drying the patch sheet to form the functional hydrogel in a semi-solid state functional hydrogel; Cutting the patch sheet having the semi-solid state of the functional hydrogel (25) into a shape corresponding to the application site of the human body;

Wherein the hydrogel is composed of polyacrylic acid, glycerin, water, sodium hydroxide, agar, polysorbate 60, and the functional material is selected from the group consisting of bark extract, Wherein the supplementary additive is a mixture of one or both of a root extract of yam root and a root extract of horse rid, and the hydrogel, the functional substance, The mixing ratio of the auxiliary additives is 80 to 90% by weight of the hydrogel, 8 to 14% by weight of the functional material and 2 to 6% by weight of the auxiliary additive.

Further, before the urethane film 10 and the nonwoven fabric 20 are bonded to each other, a step of dyeing or silk printing a selected color is further added to the urethane film or the nonwoven fabric.

The hydrogel may contain 38 to 59.6% by weight of polyacrylic acid, 8 to 18.4% by weight of glycerin, 0.8 to 1.2% by weight of sodium hydroxide, 0.8 to 1.2% by weight of agar, Wherein the supplementary additive comprises 30 to 70 wt% of a root extract of yam root when the root extract of yam and root extract are mixed, 0.8 to 1.2 wt% of Polysorbate 60, and 30 to 40 wt% of water, And 30 to 70% by weight of a horse root root extract, wherein the functional material is selected from the group consisting of 33 to 45.8% by weight of white bark bark extract, 18 to 22% by weight of cinnamon fruit extract, 18 to 22% by weight of chamomile flower extract, 18 to 22% by weight of the extract and 0.2 to 1% by weight of the adjuvant.

The adjuvant may also be selected from the group consisting of aspirin, aspirinoxycodone, Dexibuprofen, Estropipate, Flurbiprofen, Ibuprofen, Meclofenamate, ), Mefenamic acid, Naproxen, Nimesulide, Valdecoxib, and Valethamate.

The semi-solid state of the functional hydrogel is formed by aging the mixture at 50 to 80 ° C for 2 to 4 days and then drying the aged functional hydrogel for 1 to 3 days.

The patch for relieving menstrual pain using the skin temperature-responsive functional hydrogel of the present invention manufactured by the above-described method, when applied to the abdomen of a woman with a menstrual cramp, responds to skin temperature and changes the functional hydrogel into a sol state, The functional materials contained in the functional hydrogels smoothly permeate into the skin, thereby alleviating the menstrual pain. In particular, even when the skin is used for a long period of time, there is no side effect on the skin and the menstrual pain can be effectively alleviated due to the continuous elution of the functional substance give.

BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a process diagram showing a method for manufacturing a patch for mitigating menstrual pain according to the present invention;
2 is a sectional view for explaining a patch configuration for mitigating menstrual pain according to the present invention;
3 is a graph showing the result of a patch test for relieving menstrual pain according to the present invention.

1, a method for manufacturing a patch for relieving menstrual pain using a skin temperature responsive functional hydrogel according to the present invention comprises the steps of applying an adhesive 15 to one surface of a urethane film 10 and then bonding the nonwoven fabric 20 ; Preparing a functional hydrogel (25) by mixing a functional material having an effect of alleviating menstrual pain on the hydrogel and an auxiliary additive having crosslinking and moisturizing effect; Applying the functional hydrogel to the surface of the nonwoven fabric 20 or one side surface of the release film 30, and then bringing the functional hydrogel into close contact with the nonwoven fabric and the release film to form a patch sheet; Aging and drying the patch sheet to form the functional hydrogel in a semi-solid state functional hydrogel; Cutting the patch sheet having the semi-solid state of the functional hydrogel (25) into a shape corresponding to the application site of the human body;

Further, in order to colorize the pseudo-mildew mitigation patch of the present invention, dyeing or silk printing of a color selected in the urethane film or nonwoven fabric is added before the urethane film 10 and the nonwoven fabric 20 are adhered.

Hereinafter, the functional raw materials used for manufacturing the patch for relieving menstrual pain using the skin temperature responsive functional hydrogel of the present invention will be described as follows.

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1) White shrub is a deciduous broad-leaved tree which grows up to about 3m in height. Several stems stand in one place. The shell is split and the cork quality (material deposited when corking occurs) develops slightly. The woody part of the twigs is light yellowish greenish and the cheekbones are quadrangular. Leaves are two egg-shaped branches facing each other and are round egg-shaped or elliptical, with three ends. It has some sawtooth on the leaf edge. At the end of long petiole there are two moths. Many flowers bloom at the end of short branches, but the flowers in the middle do not have petals. Located on the edge is a white petal that is divided into five branches. Flowers with white petals can not bear fruit at all. It is said that all the flowers have white petals are called 頭頭花. When the fruit is ripe in the round fruit after the pinning, it falls down and dyes red. It has the efficacy of diuretic, analgesic, giant wind, blooming, extinction, and gentleness. The most common diseases are those with poor urination, joint pain, sore symptoms, back pain, bruises, and hysteresis. It is also used to treat OM.

2) The viburnum grows in the forest below the mountainside and is about 3m in height. The leaves are opposite to each other. They are round or wide, with inverted eggs. On the back of the leaf there is a glandular gland that secretes fluid and has star-shaped hairs on both sides. The petiole is 6 ~ 20mm in length and has no stipule. Flowers are white and bloom in June at the tip of a leafy branch or at the end of a stem. The corolla has hairs and the surgery is longer than the corolla. The fruit is egg-shaped nucleus and ripens red in October. Major efficacy include fever due to boils, cold due to fever, eosinophilia, dysentery, edema, removal of snakebite, pediatric marker, irritable dermatitis, pediatric parasite restriction, digestion promotion, spots, freckles, fatigue recovery, Prevention of arteriosclerosis, and the like.

3) Chamomile is also called chrysanthemum, and Europe is its origin. The stem is divided at the bottom with many branches, the height is 50 ~ 100cm, and there is a scent of a rhizome (a deciduous broad-leaved arboreous tree belonging to Rosaceae). Leaves are alternate phyllotaxis with no petiole, and the lower part encircles the stem and is split into two or three horns. The split pieces are in the shape of a line and the edges are flat. The flower blooms between June and September, and it runs on the tip of the stem and the branch with the head shape flower in the shape of the head. It is 13 ~ 20cm in diameter and consists of white tongue flower and yellow tubular flower. It is a female flower and runs on a single line. It blooms and then falls down. The gun bracts are hemispherical, the gun pieces are arranged in 4 rows, the outer pieces are long elliptical, with white hairs on the outside, rounded ends and membranous edges. The main benefits are relieving tension and warming the body, especially for pain and inflammation, such as headache, migraine, neuralgia, and menstrual cramps. It also has an effect on gastrointestinal disorders and insomnia.

4) Motherworms, also known as hair growth, grow in the field and are about 1m in height. Branches are divided and the stem cross section is dull square and white hair looks whiteish green. The leaves are opposite to each other. The leaves on the roots are egg-shaped, oval, dullly separated, and the leaves on the stem are divided into 3 pieces. The cut pieces are feathers and are again divided into 2 to 3 pieces and have saw teeth. Flowers bloom in light reddish purple in July ~ August, 6 ~ 7mm in length, and run in stratum in nodes. The calyx is divided into 5 pieces, the corolla is lips-shaped and divided into bifurcations, and the lower lips are divided into 3 pieces again. Two out of four operations are long. Fruit is small nuts with wide ovate shape, ripen in September to October, and contained in calyx. The seed has 3 ridges and the length is 2 ~ 2.5mm. Motherwort is good when there is menstrual irregularity, hemorrhage, hemorrhage, hemorrhage, menstrual overload, uterine bleeding, postpartum hemorrhage. It cleanses blood and calms the swelling of the body.

5) Yams are also known as sugar beans and grow mainly in mountain areas. The stem comes out from the flesh root of the circumference type and hoists up another object. Leaves are opposite or staggered, petiole is long, long oval or triangular, pointed end, bottom is heart-bottomed, hairless. The main shoots grow on the axilla. The flower is a single flower, blooming in June to July, and runs on a water inflorescence. The male flower ears stand upright, the female flower ears fall down, and white flowers hang. Male flowers have 6 stamens, foliage pieces and 1 pistil, and female flower has 6 filigree pieces and 1 pistil. The fruit is capsule with three wings and the seed also has membranous wings. In particular, the root of yam is root, which means that the root of the yam has grown in size due to the accumulation of nutrients, and the yam root is rich in phyto-mucin (similar to the component of snail mucus as a vegetative mucin) It is included to prevent the skin from drying out, protect the skin from the outside and exert the effect of healing wounds.

6) Horseback riding is also known as an abattoir, growing in deep mountain forests and about 1m in height. It has a thick roots and purplish black. Leaves are alternate phyllotaxis, long petiole, and divide 3 ~ 1 ~ 2 times. Small leaves are ovate, often split into 2-3, with irregular sawtooth. The flowers bloom in August to September in white, with a large conical flower on top of the stem. Calyx is 4 ~ 5 pieces, petals are 2 ~ 3 pieces, and ends are usually divided into 2 pieces. There are many surgeries and ovaries. The fruit is ripened in October as molten and ossified fruit. Breeding is done by seeding, abandoning or leaking. The main efficacy of horse riding can be seen as 升 (up) and mountain (). The word "wins" refers to the symptoms that occur when the stomach does not climb up, such as symptoms of gastrointestinal tract, intestinal wastewater, dehydration, tachypnea, and headache, literally lifting up the stamen. It means to distract the heat poison which is staying in the inside. Therefore, when riding is used as a topical agent for skin, the effect is judged on the basis of these properties. The concept of w is given from the viewpoint of giving elasticity to wrinkled skin and improving wrinkles. The concept of acid is dermatitis due to heat, It can be considered from the point of view that it releases toxic fungus which causes in trouble, and it can see effects such as antioxidation, anti-aging, moisturizing, sedation.

These functional ingredients exhibit excellent effects on skin moisturizing and women's diseases. Specifically, they inhibit the COX-2 enzyme involved in the production of prostaglandins (inhibit inflammation / coagulation, etc.) Provides a possible effect.

In the present invention, it is preferable to extract the active ingredient by a hot water extraction method having a wide extraction range, and the hot water extraction method is a method of extracting an active ingredient from the above- As already well known, this means an extraction method in which each of the obtained raw materials is washed, the washed raw material is supplied to a heating vessel together with water, and then the mixture is heated to a strong fire to be lowered to a low temperature and then quenched Since this is a conventional extraction method, a detailed description is omitted.

Hereinafter, a method for manufacturing a patch for relieving menstrual pain using the skin temperature responsive functional hydrogel according to the present invention will be described in detail as follows.

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a) bonding the nonwoven fabric to one side of the urethane film

The step a) of the present invention is a step of applying the adhesive 15 to one surface of the urethane film 10 and then bonding the nonwoven fabric 20 as shown in Fig. 2, and the reason for using the urethane film 10 This is because it is harmless to the human body, it is easy to deform according to the bending shape of the skin, and moisture evaporation can be suppressed.

The reason why the nonwoven fabric 20 is used is that it maintains a close contact force with the skin, is safe to the skin to be contacted, sufficiently functions the skin temperature responsive hydrogel of the present invention, At the same time, long-term storage is possible.

In order to colorize the patch for mitigating the menstrual pain according to the present invention, the urethane film or the nonwoven fabric may be dyed or silk printed in the selected color before the urethane film 10 and the nonwoven fabric 20 are bonded. The silk printing is one of various printing techniques in which a film is formed and then a dye is poured and pushed out with a rubber so as to stain the dye.

Alternatively, a mark such as a specific logo, a character, or a trademark may be printed on the urethane film or the nonwoven fabric. Alternatively, the urethane film or the nonwoven fabric may be embossed or embossed so as to have a curved surface.

In order to adhere the nonwoven fabric 20 to one surface of the urethane film 10, it is preferable to apply an adhesive to one surface of the urethane film, adhere the nonwoven fabric closely, and then adhere by laminating .

b) preparing a skin temperature responsive functional hydrogel

The step (b) of the present invention is a step of producing a functional hydrogel having an effect of mitigating menstrual pain, which is a main feature of the present invention and will be described separately below.

c) Patch Sheet Production Step

The functional hydrogel is applied between the nonwoven fabric 20 and the release film 30 after the functional hydrogel is applied to the surface of the nonwoven fabric 20 or one side surface of the release film 30, (Preferably a coating roller) in order to adhere the release film to the nonwoven fabric coated with the functional hydrogel on one side of the nonwoven fabric and the releasing film, .

d) Formation of semi-solid state of functional hydrogel in patch sheet

In the step d) of the present invention, the functional hydrogel contains a functional material composed of a mixture of components in the form of a liquid phase, and the functional hydrogel has a molecular structure in the sol state, When the functional hydrogel is applied, most of the functional hydrogel is separated from the nonwoven fabric, and a functional hydrogel is applied to the hand in the process of using the product by the consumer,

The patch sheet is aged and then dried to form the functional hydrogel as a semi-solid functional hydrogel. One example of forming the functional hydrogel in a semi-solid state is to aged at 50 to 80 ° C for 2 to 4 days, and then aging the functional hydrogel to dry at room temperature in a closed space for 1 to 3 days. The aging period is most preferably 2 days to 4 days, and if it exceeds 4 days, it is gradually cured so that it does not exceed 4 days. If the drying time is less than 1 day, the viscosity is too much for the skin, and if the drying time is more than 3 days, the viscosity is too small and it is easily disadvantageous when it is used.

The functional hydrogels existing between the nonwoven fabric 20 and the release film 30 are formed in a semi-solid state functional hydrogel 25 through the above-described process because they are in a state of being in a sol state, It can be prevented from flowing down.

The reason why the functional hydrogel is aged at 50 to 80 ° C for 2 to 4 days is that the polyacrylic acid, glycerin, water, sodium hydroxide, agar, polysorbate 60 (Polysorbate 60), a plant extract enzyme mixed with any one or both of the extracts of Saccharomyces bark extract, Lycopersicon esculentum, Chamomile flower extract, Is aged by the action of microorganisms and stabilized.

As described above, the patch including the functional hydrogel formed in a semi-solid state dissolves the gel-state hydrogel in response to the body temperature, i.e., the skin temperature due to the application mechanism of sodium hydroxide upon adhering to the skin, Thereby eventually transferring the functional substance to the skin.

Therefore, the functional hydrogel containing sodium hydroxide is sensitive to the skin temperature, so that the ingredient capable of mitigating menstrual pain can be easily transferred to the affected part.

e) Patch sheet cutting step

Step e) of the present invention is a step of cutting the patch sheet in which the functional hydrogel is in a semi-solid state into a shape similar to the application site of the human body, which is cut so as to be applicable to the entire abdomen of the user or a part of the abdomen of the user.

The method of manufacturing the skin temperature responsive hydrogel of step b), and the action and effect of the skin temperature responsive hydrogel of the present invention described above, will be described below.

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The functional hydrogel of the present invention comprises 80 to 90% by weight of a hydrogel, 8 to 14% by weight of a functional material and 2 to 6% by weight of an auxiliary additive,

The hydrogel is composed of polyacrylic acid, glycerin, water, sodium hydroxide, agar, polysorbate 60, and the functional material is selected from the group consisting of bark extract, And the supplementary additive is a mixture of one or both of yam root extract and horse root root extract.

Polyacrylic acid, Glycerin, water, sodium hydroxide, agar, polysorbate 60, which constitute the hydrogel, are common techniques used for preparing patches. A specific description thereof is omitted. The composition of the embodiment is 38 to 59.6% by weight of polyacrylic acid, 8 to 18.4% by weight of glycerin, 0.8 to 1.2% by weight of sodium hydroxide, 0.8 to 1.2% by weight of Agar, 0.8 to 1.2% by weight of Polysorbate 60 and 30 to 40% by weight of water.

Polyacrylic acid among the components of the hydrogel is preferably a polymer polymer in an amount of 38 to 59.6% by weight.

On the other hand, the polyacrylic acid is preferably used alone, but polyacrylic acid, polymethacrylic acid, polyacrylic acid copolymer, and polymethacrylic acid copolymer may be used alone or in combination. When the polyacrylic acid is used in an amount of less than 38% by weight, it is difficult to maintain the patch shape and adherence is deteriorated. When the polyacrylic acid is used in an amount exceeding 59.6% by weight, the release rate of the hydrogel Is lowered.

Glycerin may exert the function of a moisturizing softener, but it also serves to enhance spreadability (spreadability) by imparting viscosity as a menses emollient. The preferable content of the glycerin is 8 to 18.4 wt%.

Sodium hydroxide is an application mechanism for dissolving a gelated hydrogel into a fluidized state, and the preferable content of the sodium hydroxide is 0.8 to 1.2% by weight.

Agar is a viscous, complex polysaccharide mixture extracted by physical and chemical treatments with seaweed and the like as a main raw material, and has an effect of cleansing the blood of a cold person and normalizing the hormone secretion. 0.8 to 1.2% by weight.

In addition, polysorbate 60 (Polysorbate 60) is preferably used as a surfactant (mixture of substances having different properties), and it is preferably used in an amount of 0.8 to 1.2% by weight.

As described above, the functional material is composed of 33 to 45.8% by weight of the bark bark extract, 18 to 22% by weight of the cinnamon fruit extract, 18 to 22% by weight of the chamomile flower extract, 18 to 22% by weight of the mother- 0.2 to 1% by weight, and either or both of yam root root extract and horse root root extract, which are auxiliary additives, are mixed.

The reason why the above-mentioned functional material is mixed with either or both of the bark extract of bark bark, cinnamon fruit extract, chamomile flower extract, mother plant extract, yam root extract and horse root root extract is as described in 5) and 6) Efficacy, that is, the effect of preventing the skin from drying out, protecting the skin from the outside, and healing wounds, etc., in the patch for mitigating the menstrual pain according to the present invention. In addition, yam root extract and horse root root extract contain a large amount of glycosides such as yogogenin, creptogen, and diosgenin, which act to activate hydrolysis.

The mixing ratio of the hydrogel, the functional material and the auxiliary additive is 80 to 90% by weight of the hydrogel, 8 to 14% by weight of the functional material and 2 to 6% by weight of the auxiliary additive, Since the efficacy such as pain relief and pivotal protection is different according to the raw material, it is to standardize (apply) the different efficacies to the patch of the present invention. Here, mixing the auxiliary additive in the functional hydrogel of the present invention is intended to increase softness and moisturization of the skin even after patch removal due to the above-mentioned effects.

On the other hand, if the functional material is used in an amount of less than 8% by weight based on the total weight of the functional hydrogel patch composition, the effect of easing the menstrual pain is insufficient. If the functional material is used in an amount of more than 14% by weight, The performance of the gel may be deteriorated. Therefore, it is preferable to use it within the above-mentioned weight range.

If the auxiliary additive is used in an amount less than 2% by weight based on the total weight of the functional hydrogel patch composition, the effect is not expected to be expected. If the auxiliary additive is used in an amount exceeding 6% by weight, .

When the yam root root extract and the horse root root extract are all mixed, it is preferable that the yam root root extract and the horse root root extract are mixed at a ratio of 30 to 70:30 to 70% by weight.

Hereinafter, the efficacy of the adjuvant contained in the functional material will be described.

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1) Aspirin is a salicylic acid derivative used as antipyretic, antirheumatic, and anti-rheumatic drugs. Its analgesic effect is inhibited by central hypothalamus suppression and suppression of impulse generation by hyperpigmentation at the peripheral site, Inhibition of the activity of the substance, and the like. The antipyretic action is caused by acting on the upper and lower body temperature control centers during the cerebellum and increasing the blood circulation of the peripheral blood vessels to increase the heat dissipation. It also inhibits prostaglandin synthesis by irreversibly acetylating cyclooxygenase and exhibits anti-inflammatory, analgesic and antipyretic effects.

2) Aspirin oxycodone (Aspirinoxycodon) is effective in relieving inflammatory and neurogenic pain in the skin and surrounding tissues.

3) Dexibuprofen is one of the ibuprofen family, which, like ibuprofen, inhibits the COX-2 enzyme involved in prostaglandin production, a mediator of pain and inflammation, but only half as effective as ibuprofen.

4) Estropipate is effective in the prevention of moderate to severe vasomotor symptoms associated with menopause, vulvar and vaginal atrophy, hypogonadism, ovarian excretion, or controlled strepeny due to primary ovarian disease and osteoporosis.

5) Flurbiprofen is a nonsteroidal (NAAID) ingredient that has anti-inflammatory and analgesic properties.

6) Ibuprofen is an inhibitor of the COX-2 enzyme involved in the production of prostaglandins, a mediator of pain and inflammation.

7) Meclofenamate is effective in the treatment of women's primary dysmenorrhea by inhibiting COX-2 enzyme.

8) Mefenamic acid is effective for the treatment of arthritis and limb pain by acting as a mediator, a paracetamol.

9) Naproxen is an anti-inflammatory analgesic used in rheumatoid arthritis and migraine.

10) Nimesulide is effective for acute pain (post-operative pain, toothache, headache, back pain).

11) Valdecoxib is a COX-2 inhibitor and is effective against rheumatoid arthritis.

12) Valethamate is a potent inhibitor of parasympathetic peripheral nerves and is effective in relieving abnormal tension of smooth muscle such as bronchial, digestive, spleen, gallbladder, uterus, ureter and bladder.

These adjuvants include those commonly used for relieving pain, and the effect to be achieved by the present invention can be further enhanced by being mixed with the above-mentioned functional raw materials.

Hereinafter, the present invention will be described more specifically by way of Examples and Experimental Examples.

However, the scope of the present invention is not limited by the examples and experimental examples described below.

( Example 1) Functionality Hydro Preparation of gel patches

After applying an adhesive to one side of the urethane film, the nonwoven fabric was adhered to the polyacrylic acid, glycerin, water, sodium hydroxide, agar, and polysorbate 60 to obtain a white bark extract, a cinnamon fruit extract, a chamomile flower extract, A functional hydrogel mixed with ibuprofen and yam root extract is applied to the surface of the nonwoven fabric and then the functional hydrogel is brought into close contact with the nonwoven fabric and the release film to form a patch sheet, , Aged at a temperature of 60 캜 for 3 days, and then the aged functional hydrogel was dried for 2 days and cut to a width of 18 cm and a length of 10 cm to prepare a functional hydrogel patch for relieving menstrual pain. The contents of the above components are shown in Table 1 below.

( Example 2) Functionality Hydro Preparation of gel patches

A functional hydrogel patch for dysmenorrhea relief was prepared in the same manner as in Example 1 except that polyacrylic acid, glycerin, sodium hydroxide, agar, polysorbate 60, white sugar bark extract, cinnamon fruit extract, chamomile flower extract, , And the contents of the components of ibuprofen were varied. The contents of the above components are shown in Table 2 below.

( Comparative Example 1) General Hydro Preparation of gel patches

As a control group of the functional hydrogel patch of the present invention, a hydrogel patch was prepared in the same manner as in Example 1 except for the components of the bark bark bark extract, cinnamon fruit extract, chamomile flower extract, mother plant extract, and ibuprofen. However, the content of polyacrylic acid, glycerin, water, sodium hydroxide, agar, polysorbate 60, and yam root extract was the same as in Example 1. The contents of the above components are shown in Table 3 below.

( Comparative Example 2) General Hydro Preparation of gel patches

As a control group of the functional hydro-gel gel patch of the present invention, hydrogel patches were prepared in the same manner as in Example 1 except for the components of Saccharomyces cerevisiae bark extract, cinnamon fruit extract, chamomile flower extract, mother plant extract and ibuprofen . However, the content of polyacrylic acid, glycerin, water, sodium hydroxide, agar, polysorbate 60, and yam root extract was the same as in Example 2. The contents of the above components are shown in Table 4 below.

Ingredients content
(Unit: g) Polyacrylic acid
(Polyacrylic acid) 38 glycerin
(Glycerin) 11 Sodium hydroxide
(Sodium hydroxide) 1.2 Baby
(Agar) One Polysorbate 60
(Polysorbate 60) One water 30 White bark bark extract 3.5 Vermicelli fruit extract 2 Chamomile flower extract 2 Motherwort extract 2 Ibuprofen
(Ibuprofen) 0.05 Yam root root extract 5

Ingredients content
(Unit: g) Polyacrylic acid
(Polyacrylic acid) 40 glycerin
(Glycerin) 10 Sodium hydroxide
(Sodium hydroxide) 1.4 Baby
(Agar) 1.2 Polysorbate 60
(Polysorbate 60) 1.2 water 30 White bark bark extract 3.0 Vermicelli fruit extract 1.5 Chamomile flower extract 1.5 Motherwort extract 1.5 Ibuprofen
(Ibuprofen) 0.03 Yam root root extract 5

Ingredients content
(Unit: g) Polyacrylic acid
(Polyacrylic acid) 38 glycerin
(Glycerin) 11 Sodium hydroxide
(Sodium hydroxide) 1.2 Baby
(Agar) One Polysorbate 60
(Polysorbate 60) One water 30 White bark bark extract - Vermicelli fruit extract - Chamomile flower extract - Motherwort extract - Ibuprofen
(Ibuprofen) - Yam root root extract 5

Ingredients content
(Unit: g) Polyacrylic acid
(Polyacrylic acid) 40 glycerin
(Glycerin) 10 Sodium hydroxide
(Sodium hydroxide) 1.4 Baby
(Agar) 1.2 Polysorbate 60
(Polysorbate 60) 1.2 water 30 White bark bark extract - Vermicelli fruit extract - Chamomile flower extract - Motherwort extract - Ibuprofen
(Ibuprofen) - Yam root root extract 5

( Experimental Example ) Measurement of periodontal pain index by hour

Subjects were 30 students from 18 to 24 years of age and 15 students in each of Examples 1 and 2 of the present invention and 15 students in Comparative Examples 1 and 2 were assigned a total of 60 students Respectively. When there is signs of menstrual cramps, they are used once a day in the abdomen. And, during the lab period, other medications were prohibited.

The range of the menstrual cramps is from 0 to 10, and the higher the score, the higher the strength of the menstrual cramps (10 point scale).

On the other hand, in the comparative examples (Tables 5 and 6 below), a hydrogel patch excluding the functional substance (dysmenorrhoea agent) was attached to the abdomen. Experimental examples (Tables 7 and 8 below) A hydrogel patch containing a functional substance was attached to the abdomen and tested. And, in order to easily confirm the data change of Tables 5 to 8, it is shown in FIG. 3 as a graph.

- Comparative Example 1 - Before use After 1 hour After 2 hours After 3 hours After 6 hours After 12 hours After 24 hours Experiment 1 4 6 7 6 4 7 5 Experiment 2 3 4 6 5 4 5 4 Experiment 3 6 6 7 5 4 6 5 Experiment 4 7 8 7 7 6 6 5 Expert 5 6 5 6 5 4 5 4 Experiment 6 5 6 5 6 5 6 4 Expert 7 7 5 6 5 4 6 5 Expert 8 3 6 5 5 5 4 3 Expert 9 8 9 9 7 6 5 4 Expert 10 7 5 6 6 5 6 5 Expert 11 5 6 5 4 3 4 3 Expert 12 9 10 8 8 7 6 5 Expert 13 6 7 6 5 4 5 6 Expert 14 7 6 8 7 6 7 7 Expert 15 4 6 6 5 4 5 6 Average 5.8 6.3 6.4 5.7 4.7 5.5 4.7

- Comparative Example 2 - Before use After 1 hour After 2 hours After 3 hours After 6 hours After 12 hours After 24 hours Experiment 1 7 8 7 6 5 7 4 Experiment 2 4 5 5 5 5 6 5 Experiment 3 5 5 6 4 5 4 3 Experiment 4 8 6 7 8 8 5 6 Expert 5 3 4 6 5 4 7 6 Experiment 6 6 5 4 4 3 5 4 Expert 7 4 6 4 5 5 6 5 Expert 8 6 6 7 6 5 3 4 Expert 9 5 7 6 6 5 4 4 Expert 10 6 7 5 4 6 5 5 Expert 11 7 8 8 7 6 5 4 Expert 12 6 7 5 6 7 8 7 Expert 13 7 5 6 6 7 6 5 Expert 14 5 6 6 6 7 7 6 Expert 15 8 9 8 7 8 7 6 Average 5.8 6.2 6.0 5.6 5.7 5.6 4.9

- Example 1 - Before use After 1 hour After 2 hours After 3 hours After 6 hours After 12 hours After 24 hours Experiment 1 8 7 5 4 3 2 2 Experiment 2 6 6 5 3 2 2 One Experiment 3 5 4 3 3 2 One One Experiment 4 7 6 4 4 3 2 One Expert 5 5 5 4 4 2 One One Experiment 6 7 7 5 4 2 2 One Expert 7 5 5 4 3 2 2 One Expert 8 6 5 3 2 2 2 One Expert 9 4 4 3 3 2 2 One Expert 10 7 5 4 4 3 2 One Expert 11 8 6 5 4 3 3 2 Expert 12 6 5 4 3 One One One Expert 13 5 5 4 3 3 2 One Expert 14 7 7 6 5 3 2 2 Expert 15 7 6 5 4 3 2 One Average 6.2 5.5 4.2 3.5 2.4 1.8 1.2

- Example 2 - Before use After 1 hour After 2 hours After 3 hours After 6 hours After 12 hours After 24 hours Experiment 1 7 7 6 4 3 2 2 Experiment 2 8 7 7 6 5 4 3 Experiment 3 6 6 5 4 4 3 2 Experiment 4 5 5 5 4 3 3 2 Expert 5 6 5 5 4 3 2 One Experiment 6 8 8 6 6 5 3 2 Expert 7 4 4 3 3 2 2 One Expert 8 5 5 5 4 3 3 2 Expert 9 7 7 6 5 4 3 2 Expert 10 6 5 4 3 3 2 2 Expert 11 5 5 4 4 3 One One Expert 12 7 6 6 5 3 2 One Expert 13 5 5 4 3 2 2 2 Expert 14 6 6 5 5 4 3 2 Expert 15 5 5 4 4 3 2 One Average 6.0 5.7 5.0 4.2 3.3 2.4 1.7

As can be seen from the above experimental results, the effectiveness of the functional hydrogel patch and the general hydrogel patch (containing no functional substance) over time according to the present invention is lowered by the effect of the functional hydrogel patch of the present invention compared to a general hydrogel patch Were more excellent.

In addition, through this experiment, it was found that the effect of the functional substance (bacillus thunbergii extract, chrysanthemum bark extract, chamomile flower extract, mother plant extract, and adjuvant ibuprofen) on masticatory pain relief and duration The result of going crazy was also able to be derived.

In particular, by developing a patch for relieving menstrual pain using the functional hydrogel of the present invention, which lasts for a long time compared to a conventional menstrual pain or patch, and is only required to be easily attached to the wearer during activity or sleeping, a high moisture content, a biocompatibility, The effectiveness of the raw materials having the effect of mitigating the menstrual pain to the activity is doubled, so that the effective easing agent effect can be expected.

While the present invention has been described in connection with certain exemplary embodiments and experimental examples, it is to be understood that the invention is not limited thereto and that various changes and modifications will be apparent to those skilled in the art. It will be understood that various modifications and changes may be made without departing from the scope of the appended claims.

10: urethane film 25: hydrogel
15: Adhesive 30: Release film
20: Nonwoven

Claims

Applying an adhesive (15) to one side of the urethane film (10) and then bonding the nonwoven fabric (20);
Preparing a functional hydrogel (25) by mixing a functional material having an effect of alleviating menstrual pain on the hydrogel and an auxiliary additive having crosslinking and moisturizing effect;
Applying the functional hydrogel to the surface of the nonwoven fabric 20 or one side surface of the release film 30, and then bringing the functional hydrogel into close contact with the nonwoven fabric and the release film to form a patch sheet;
Aging and drying the patch sheet to form the functional hydrogel in a semi-solid state functional hydrogel;
Cutting the patch sheet having the semi-solid state of the functional hydrogel (25) into a shape corresponding to the application site of the human body;
The hydrogel is composed of polyacrylic acid, glycerin, water, sodium hydroxide, agar, polysorbate 60,
The functional material is a mixture of bark bark bark extract, cinnamon fruit extract, chamomile flower extract, mother plant extract,
The auxiliary additive is a mixture of any one or both of yam root extract and horse root root extract,
Wherein the mixing ratio of the hydrogel to the functional material and the auxiliary additive is 80 to 90% by weight of the hydrogel, 8 to 14% by weight of the functional material and 2 to 6% by weight of the auxiliary additive. .

The method according to claim 1,
Wherein the step of dyeing or silk printing the color of the urethane film or the nonwoven fabric is further added before the adhesion of the urethane film (10) and the nonwoven fabric (20).

The method according to claim 1,
Wherein the hydrogel contains 38 to 59.6% by weight of polyacrylic acid, 8 to 18.4% by weight of glycerin, 0.8 to 1.2% by weight of sodium hydroxide, 0.8 to 1.2% by weight of agar, 0.8 to 1.2% by weight of Polysorbate 60, and 30 to 40% by weight of water.

The method according to claim 1,
Wherein the auxiliary additive is mixed at a ratio of 30 to 70% by weight of the root extract of yam root and 30 to 70% by weight of the horse root root extract when the root extract of yam root is mixed with the horse root root extract. A method for manufacturing a mitigating patch.

The method according to claim 1,
Wherein the functional material is at least one selected from the group consisting of 33 to 45.8% by weight of a saccharide bark extract, 18 to 22% by weight of a cinnamon fruit extract, 18 to 22% by weight of a chamomile flower extract, 18 to 22% Wherein the hydrogel is a mixture of water and an organic solvent.

6. The method according to any one of claims 1 to 5,
The adjuvant is selected from the group consisting of aspirin, aspirin oxycodone, Dexibuprofen, Estropipate, Flurbiprofen, Ibuprofen, Meclofenamate, Wherein the hydrogel is any one selected from the group consisting of Mefenamic acid, Naproxen, Nimesulide, Valdecoxib and Valethamate. Way.

The method according to claim 1,
Wherein the functional hydrogel is aged at 50 to 80 ° C for 2 to 4 days and then the aged functional hydrogel is dried for 1 to 3 days.

A patch for relieving menstrual pain using a hydrogel prepared by the method of any one of claims 1 to 7.