KR20170065959A - Cosmetic Composition For Mask Pack Comprising Extract Of Mangosteen And Sericin Extracted From Golden Silk Silkworm Cocoon - Google Patents
Cosmetic Composition For Mask Pack Comprising Extract Of Mangosteen And Sericin Extracted From Golden Silk Silkworm Cocoon Download PDFInfo
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- KR20170065959A KR20170065959A KR1020150172384A KR20150172384A KR20170065959A KR 20170065959 A KR20170065959 A KR 20170065959A KR 1020150172384 A KR1020150172384 A KR 1020150172384A KR 20150172384 A KR20150172384 A KR 20150172384A KR 20170065959 A KR20170065959 A KR 20170065959A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The present invention provides a cosmetic composition for a mask pack, which comprises a natural material extract capable of delaying skin damage and aging and alleviating the symptoms of atopic dermatitis, Wherein the mangosteen extract comprises 0.001 to 20% by weight based on the total weight of the extract, and the sericin extracted from the golden silkworm cocoate is 0.001 to 20% by weight based on the total weight of the mangosteen extract, And a control unit.
Description
The present invention relates to a cosmetic composition for a mask pack, and more particularly, to a cosmetic composition for a mask pack comprising, as an active ingredient, sericin extracted from a mangosteen extract and a golden silkworm cocoon.
Recently, as the cosmetics-related industries such as the bio-industry and the biotechnology have developed remarkably, there has been a demand for functional cosmetics having improved effects on aging and skin diseases, Is increasing.
In view of this, in recent years, various natural materials have been used as raw materials for improving the functions of anti-aging, whitening, moisturizing and the like in the field of mask packs. For example, Korean Patent Laid-Open No. 10-2001-0049338 (hereinafter referred to as "Patent Document 1") refers to a cosmetic pack containing cucumber, citrus, aloe, carrot, wormwood, potato, cactus, Korean Patent Laid-Open No. 10-2007-0061135 (hereinafter referred to as "Patent Document 2") discloses peel-off cosmetic packs containing extracts obtained from plants such as cucumber and apricot or seaweeds such as kelp. .
On the other hand, human skin is constantly in contact with oxygen, and persistent UV exposure or stress causes the production of reactive oxygen species (ROS). The active oxygen species (ROS) are oxygen species with a large oxidizing power, and include oxygen radicals such as superoxide anion radical (O2 .- ) and hydroxyl radical (.OH), as well as hydrogen peroxide (H 2 O 2 ) 1 O 2 ), which can cause skin mineralization damage.
That is, these active oxygen species (ROS) cause collapse of collagen and elastin in skin dermis as well as oxidization of lipids, proteins and DNA constituting cells, followed by disruption of the antioxidant defense network in vivo, and abnormal cross- It is known to accelerate aging.
Further, today, harmful urban environments such as fine dusts, excessive use of food additives and chemicals accelerate skin damage and aging, and are known to cause atopic dermatitis, also known as chronic skin disease.
These atopic dermatitis is an eczematous disease commonly found on the face, folded arms, and the back of the knee. It usually feels dry and rough, and accompanied by severe itching. Various steroids used in the treatment of atopic dermatitis Immunomodulators are known to have a greater risk of side effects such as skin atrophy and vasodilation due to steroids as well as drug resistance when used over a long period of time.
Therefore, apart from the medical treatment for atopic dermatitis, it is necessary to develop a cosmetic product using a natural substance which can alleviate symptoms of atopic dermatitis.
In other words, in order to delay the damage and aging of the skin and alleviate the symptoms of atopic dermatitis, it is necessary to develop cosmetics using natural substances having antioxidative, anti-inflammatory or antibacterial ability.
The object of the present invention is to provide a cosmetic composition for a mask pack comprising a natural material extract which can delay skin damage and aging and alleviate symptoms of atopic dermatitis as an effective ingredient.
The cosmetic composition for a mask pack according to the present invention is characterized by containing mangosteen extract and sericin extracted from golden cocoons as an active ingredient.
The mangosteen extract of the cosmetic composition for a mask pack according to the present invention contains 0.001 to 20% by weight based on the total weight of the cosmetic composition, and the sericin extracted from the golden cocoons contains 0.001 to 20% by weight based on the total weight of the composition .
The mangosteen extract of the cosmetic composition for a mask pack according to the present invention is prepared by mixing mangosteen fruit with 10 times the weight of mangosteen and extracting it for 6 hours at an extraction temperature of 60 ° C in an extraction flask equipped with a vertical reflux condenser, And extracted by ultrasonic wave extraction with ultrasonic wave of 40 KHz for 30 minutes through an ultrasonic wave extractor.
The mangosteen extract of the cosmetic composition for a mask pack according to the present invention is characterized in that the mangosteen extract is prepared in the form of nano-sized liposome collected by lecithin or gelatin.
The sericin of the cosmetic composition for a mask pack according to the present invention is prepared by mixing golden silkworm cocoons with distilled water at a bath ratio of 1:15 to 25, subjecting the mixture to hot extraction at a high temperature of 80 to 120 ° C for 1 to 3 hours, Or protease enzymes and hydrolyzing them to form low molecular weight proteins.
According to the present invention, by containing mangosteen extract and sericin extracted from golden cocoons as an active ingredient, it is possible to delay skin damage and aging and alleviate symptoms of atopic dermatitis.
The cosmetic composition for magpac according to the present invention contains mangosteen extract and sericin extracted from golden cocoons as an active ingredient.
<Mangosteen extract>
(1) Characteristics of mangosteen
Mangosteen is a tropical evergreen tree of the pepper tree. Scientific name is Garcinia mangostana. Its origin is Southeast Asia. It is about 10m in height and 1m in diameter. Mangosteen fruit is used to treat skin infections, wounds, muscle and bone pain relief, , And has been used as a remedy for diarrhea.
These mangosteen berries are slightly flattened, slightly larger than a table tennis ball, 4 to 7 cm in diameter, 5 months after the flowers are faded, purplish black with calyxes attached, seeds radially lined up, Eat meat. In particular, mangosteen peels are known to contain xanthones, which are various physiologically active substances. Xanthone has been reported to have various effects such as antioxidation, anti-inflammation and antibacterial activity.
However, the possibility of functional cosmetics as a raw material for such mangosteen has not been studied.
(2) Extraction of mangosteen
Conventional hydrothermal extraction has a disadvantage of high energy consumption due to low extraction efficiency and disadvantages such as destruction of useful components due to heat, variation of protein, loss of components, extraction of soluble fraction. On the other hand, when ultrasonic energy is used for extraction, very large energy is generated by cavitation due to ultrasonic vibration, and because of the local temperature, kinetic energy of the reactant particles located at the periphery is increased, And the efficiency of the extraction process can be increased because the high pressure is induced by the shock effect of the ultrasonic energy to increase the mixing effect.
Therefore, in the present invention, hot water and ultrasonic parallel extraction methods are used to compensate for the disadvantages of the hot water extraction method.
That is, in the present invention, the mangosteen fruit (hereinafter referred to as "mangosteen") is dried and then mixed with 10 times the dry weight of mangosteen distilled water (extraction solvent), and the extraction temperature in an extraction flask equipped with a vertical reflux condenser 60 ° C for 6 hours, and sonicated for 30 minutes at 40 KHz through an ultrasonic extractor to obtain an extract. The extracts obtained by hot water and ultrasonic parallel extraction were filtered with a vacuum filter, concentrated and lyophilized.
(3) Nanoparticles of mangosteen extract
When the mangosteen extract is applied to the skin of human body as a cosmetic formulation (cream type, essence type, etc.) in order to exhibit the efficacy of sulfation, antibacterial and anti-inflammation as a raw material for functional cosmetics, mangosteen extract Should reach the dermis on the skin below the epidermis.
Of course, even when the mangosteen extract does not reach the dermis, the skin cosmetic composition containing the mangosteen extract is applied to the skin, or when the composition is applied to the skin as a mask pack type, a skin moisturizing film is formed on the skin having atopic symptoms, Although it may exhibit anti-inflammatory efficacy, it is desirable to have a sufficient amount of mangosteen extract to reach the dermis in the subcutaneous layer of the skin in order to have a more fundamental and lasting effect.
However, since the endothelial cells of the human skin are composed of phospholipids and water soluble components are difficult to penetrate, simply applying a cosmetic composition containing a water-soluble mangosteen extract to the skin is sufficient to obtain a sufficient amount of mangosteen extract It is difficult to expect that the ingredients will reach the dermis in the skin below the epidermis.
On the other hand, the material has a new physico-chemical characteristic on the nanometer (10 -9 m) scale, and liposome-type nanoparticles are known to easily penetrate the human body.
Since the liposome is a colloid structure in which amphiphilic lipids molecules are gathered together in an aqueous solution and water-soluble substances exist between the inner aqueous phase and the oil soluble layer in the bilayer wall, the liposomes serve as mediators for transferring physiologically active natural ingredients relatively stably to the skin Can play a role.
Accordingly, in the present invention, a mangosteen extract is prepared in the form of nano-sized liposome captured with lecithin or gelatin, so that a sufficient amount of the mangosteen extract component reaches the dermis in the subcutaneous layer of the skin.
The manufacture of nano-sized mangosteen extracts Lecithin and gelatin were dissolved in a round bottom flask, and a multilayer was formed by using a pressure reducer. Then, a liquid bacterium extract sample dissolved in distilled water at a concentration of 1 mg / ml was put into a completely dried round bottom flask formed with a layer, And then homogenized at room temperature for 2 hours to prepare water-soluble nanoparticles
As a result of measuring the nanoparticles obtained by collecting mangosteen extract with lecithin and the nanoparticles obtained by collecting bokbunja extract with gelatin and measuring it with Dynamic Light Scattering (DLS, BENTHOS, USA), lecithin nanoparticles were found to be in the range of 10 to 100 Nm, and the gelatin nanoparticles were formed in the range of 100 to 300 nm. In other words, it was confirmed that nanoparticles of different sizes could be produced depending on the kind of the collected material.
In addition, even in the case of nanoparticles obtained by capturing mangosteen extract with gelatin, liposomes having a hydrophobic surface of 100 nm or less can be easily absorbed by living organisms, The nanoparticles obtained by collecting mangosteen extract with lecithin are preferable.
<Sericin extract from golden silkworm cocoon>
(1) Characteristics of golden cocoons
Silk from silkworm cocoons consists of two proteins, fibroin and sericin. Among them, fibroin is the fiber we call silk, and sericin is the protein that surrounds two fibroin.
Typically, sericin is removed through the refining process of silk, and after the sericin has been removed, the silk has inherent gloss and texture. Sericin accounts for about 25% of the total silk protein, , When such refining waste containing sericin is discharged into a river, it eventually causes eutrophication of the river, which causes pollution.
Therefore, many researches have been made on a method for recovering sericitin, which has been discarded in the meantime, and using it as a renewable resource. Serine is characterized by high content of hydrophilic amino acid and serine occupies about 30% The amino acid composition of sericin is known to be superior to the natural moisturizing factor (NMF) of the human body, and thus it is known as an excellent material for skin moisturizing effect. In addition to the moisturizing effect, sericin is also known to be effective in suppressing the sulfation effect, lipid peroxidation and inhibition of tyrosinase activity Whitening effect, and skin cancer inhibitory effect.
On the other hand, yellow cocoons prepared by "Golden Silk", a variety cultivated by crossing the Japanese silkworm 311 (JS169) and Chinese silkworm 312 (CS186) It is known to contain more sericin than common silkworms.
(2) Extraction of sericin
In general, as a refining method for isolating sericin from cocoon, hot water extraction method, soap refining method, alkali-salt refining method, and the like are known.
Soap scouring or alkaline-salt scouring has been widely used in the industrial field for producing silk. However, since the soap scouring method and the alkali-salt scouring method are based on the assumption that sericin attached to fibroin is removed and discarded, Separating and recovering pure sericin from the refining process by these methods requires a separate step of filtering the surfactant or base added in the refining process, and it is also difficult to obtain pure sericin.
On the other hand, the hot water extraction method uses only distilled water at a high temperature of 80 to 120 ° C. In this case, by using only pure water, an additional step is not required to recover sericin after refining to separate sericin as in the case of the soap refining method and the like.
Therefore, as a method for separating sericin in the embodiment of the present invention, hot water extraction method using only the raw silk separated from the golden silk cocoons and distilled water was used.
However, sericin is known to be hydrophilic and easy to dissolve in water, but cericin surrounding the fibroin has a layered structure that is less likely to dissolve in water from the outer layer to the inner layer. That is, at a low temperature of 50 to 60 占 폚, only a part of sericin in the outer layer is dissolved in water and sericin in the inner layer is not dissolved.
Therefore, in the present invention, sericin attached to the silkworm of the golden silkworm cocoons is separated by refining the silkworm of golden silkworm cocoons and the ratio of the distilled water to the ratio of 1:15 to 25 at a high temperature of 80 to 120 ° C for 1 to 3 hours Respectively.
In addition, although sericin is generally known as a hydrophilic protein, sericin prepared by hydrothermal extraction still remains as a polymer substance, so that its solubility in water is lowered even after being powdered. When the solubility in water is low, there is a problem that it is difficult to use it as a raw material for cosmetics to be mixed with other constituent substances by water.
In order to solve the problem of the solubility of sericin in water, sericin was made low in molecular weight through hydrolysis in the process of recovering sericin from the extracted sericin aqueous solution in the example of the present invention.
A method of hydrolyzing sericin under acidic or basic conditions by a hydrolysis method of sericin is well known. However, in this case, an additional process of neutralization desalting is required, and sericin is hydrolyzed indiscriminately, resulting in reproducibility of product performance. Therefore, in the embodiment of the present invention, a method of making low molecular weight by using an enzyme was used. When enzymes are used, a specific reaction occurs, sericin molecules having a constant molecular weight can be reproducibly produced, and a safe process can be obtained because no harmful substances such as hydrochloric acid or sodium hydroxide are used.
That is, in the examples of the present invention, hydrolysis was performed using an alcalase enzyme, a flavorzyme enzyme, and a protamex enzyme in the extracted sericin aqueous solution, The amount of enzyme added to the aqueous solution was hydrolyzed at 37 ° C for 6 hours by adding 10 μl of the alkalase enzyme, 80 mg of the flavosome enzyme, and 10 mg of the protease per 1 g of sericin.
The molecular weight of sericin extracted by hydrolysis was about 66 kDa, whereas the enzyme hydrolyzed with alkaline enzyme showed the majority of sericin hydrolyzate in the range of about 14 to 66 kDa Especially at 34 kDa and 27 kDa peaks. In addition, hydrolysis with Flavobaim enzyme showed a broad molecular weight distribution and a high peak at 11 kDa. In hydrolysis with protease enzymes, the molecular weight was 13 to 66 kDa, The peaks of the 33 kDa sericin molecule were strong.
In other words, all of the alkalase, flavosome, and protease enzymes were effective in lowering sericin. Therefore, hydrolysis can be preferably performed by adding an alkaline protease, a flavozym enzyme or a protease enzyme to the sericin aqueous solution, and when two kinds of enzymes are used, the added amount of each enzyme is 1 / 2 < / RTI > to mix the two enzymes.
Examples of the method for pulverizing sericin recovered from the sericin aqueous solution include the freeze-drying method, spray drying method, and freeze-thawing method.
The freeze-drying method is a method of drying at -40 ° C for a long period of time and then drying under vacuum. However, it has a disadvantage of high time and energy consumption. In the spray drying method, the sericin solution is heated in a high- The powder can be recovered in a short period of time. However, it is not suitable for the powdering of sericin due to high energy and low recovery rate.
On the other hand, the freeze-thawing method is preferable in that the sericin proteins induce a large association behavior in the process of freezing and thawing, thereby allowing the precipitated sericin to be easily pulverized. .
Therefore, in the embodiment of the present invention, a sericin aqueous solution hydrolyzed by the enzyme is concentrated through a separation process using a tubular ultrafiltration membrane having a cutoff molecular weight of 4,000, and then the concentrated sericin solution is added to a freezing chamber Sericin powder was obtained by thawing after a certain period of freezing process.
<Composition of cosmetics>
The cosmetic material for a magpaccine according to the present invention may be prepared in various forms such as gel, paste, cream, essence, etc. The cosmetic material may contain 0.001 to 20% by weight of mangosteen extract, And 0.001 to 20% by weight of sericin, respectively.
At this time, the amount of mangosteen extract contained in the cosmetic or the amount of sericin extracted from the golden silkworm can be appropriately controlled or excluded depending on the function and use of the mask pack. For example, it is preferable to increase the specific gravity of mangosteen extract when the skin moisturizing function of the mask pack is emphasized, and when the use of the mask pack is skin external treatment such as prevention of skin disease or skin improvement.
Claims (5)
Wherein the mangosteen extract comprises 0.001 to 20 wt% of the total weight of the mangosteen extract, and the sericin extracted from the golden cocoons contains 0.001 to 20 wt% of the total weight of the mangosteen extract.
The mangosteen extract was prepared by mixing mangosteen fruit with 10 times the weight of mangosteen distilled water and extracting it in an extraction flask equipped with a vertical reflux condenser at an extraction temperature of 60 ° C for 6 hours and then ultrasonically extracting it with ultrasound at 40KHz And extracting the mixture by ultrasonic wave extraction for a minute in parallel.
The cosmetic composition for a mask pack, wherein the mangosteen extract is prepared in the form of nano-sized liposome obtained by collecting mangosteen extract with lecithin or gelatin.
The sericin is prepared by mixing golden silkworm cocoons with distilled water at a ratio of 1:15 to 25, subjecting the mixture to hot extraction at a high temperature of 80 to 120 ° C for 1 to 3 hours and then adding one or more alcalase, And hydrolyzing it to form a low-molecular-weight cosmetic composition.
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| KR1020150172384A KR20170065959A (en) | 2015-12-04 | 2015-12-04 | Cosmetic Composition For Mask Pack Comprising Extract Of Mangosteen And Sericin Extracted From Golden Silk Silkworm Cocoon |
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| KR1020150172384A KR20170065959A (en) | 2015-12-04 | 2015-12-04 | Cosmetic Composition For Mask Pack Comprising Extract Of Mangosteen And Sericin Extracted From Golden Silk Silkworm Cocoon |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190024637A (en) * | 2017-08-31 | 2019-03-08 | (주)화니핀코리아 | Cosmetic composition of high viscosity cream type and mask pack using the same |
| CN110857483A (en) * | 2018-08-23 | 2020-03-03 | 株式会社Lg生活健康 | Sheet for face mask comprising color silk produced by partial refining and face mask using the same |
| KR20230009583A (en) | 2021-07-09 | 2023-01-17 | (주)두드림 | Cosmetic Composition Containing Sericin Derive From Silkworm and Aloe Barbadensis Leaf Extract |
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2015
- 2015-12-04 KR KR1020150172384A patent/KR20170065959A/en active IP Right Grant
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190024637A (en) * | 2017-08-31 | 2019-03-08 | (주)화니핀코리아 | Cosmetic composition of high viscosity cream type and mask pack using the same |
| CN110857483A (en) * | 2018-08-23 | 2020-03-03 | 株式会社Lg生活健康 | Sheet for face mask comprising color silk produced by partial refining and face mask using the same |
| KR20200022727A (en) * | 2018-08-23 | 2020-03-04 | 주식회사 엘지생활건강 | Cosmetic of sheet comprising color silk produced by a part refining method and maskpack thereof |
| CN110857483B (en) * | 2018-08-23 | 2023-09-15 | 株式会社Lg生活健康 | Sheet for facial mask containing colored silk made by partial refining and facial mask using same |
| KR20230009583A (en) | 2021-07-09 | 2023-01-17 | (주)두드림 | Cosmetic Composition Containing Sericin Derive From Silkworm and Aloe Barbadensis Leaf Extract |
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