KR20170064799A - A wound hydrogel dressing substance with discoloring function - Google Patents
A wound hydrogel dressing substance with discoloring function Download PDFInfo
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- KR20170064799A KR20170064799A KR1020150170723A KR20150170723A KR20170064799A KR 20170064799 A KR20170064799 A KR 20170064799A KR 1020150170723 A KR1020150170723 A KR 1020150170723A KR 20150170723 A KR20150170723 A KR 20150170723A KR 20170064799 A KR20170064799 A KR 20170064799A
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- hydrogel
- dressing material
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- color
- hydrogel dressing
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- 239000000017 hydrogel Substances 0.000 title claims abstract description 79
- 239000000126 substance Substances 0.000 title description 3
- 239000000463 material Substances 0.000 claims abstract description 40
- 238000002845 discoloration Methods 0.000 claims abstract description 20
- 239000003795 chemical substances by application Substances 0.000 claims description 30
- 239000007864 aqueous solution Substances 0.000 claims description 10
- STZCRXQWRGQSJD-GEEYTBSJSA-M methyl orange Chemical compound [Na+].C1=CC(N(C)C)=CC=C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 STZCRXQWRGQSJD-GEEYTBSJSA-M 0.000 claims description 10
- 229940012189 methyl orange Drugs 0.000 claims description 10
- 239000000975 dye Substances 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 6
- 229920000936 Agarose Polymers 0.000 claims description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 229920002401 polyacrylamide Polymers 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 2
- 239000003086 colorant Substances 0.000 claims description 2
- 229920002674 hyaluronan Polymers 0.000 claims description 2
- 229960003160 hyaluronic acid Drugs 0.000 claims description 2
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 claims description 2
- 238000004040 coloring Methods 0.000 claims 4
- 229940072056 alginate Drugs 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 238000005562 fading Methods 0.000 claims 1
- 210000000416 exudates and transudate Anatomy 0.000 abstract description 13
- 206010052428 Wound Diseases 0.000 description 29
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- 239000001048 orange dye Substances 0.000 description 8
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- 239000002253 acid Substances 0.000 description 2
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- 230000000740 bleeding effect Effects 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
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- 238000001035 drying Methods 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000001678 irradiating effect Effects 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000037390 scarring Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- 102100026735 Coagulation factor VIII Human genes 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
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- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 1
- 235000000177 Indigofera tinctoria Nutrition 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
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- 206010039509 Scab Diseases 0.000 description 1
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- 239000008272 agar Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000008952 bacterial invasion Effects 0.000 description 1
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- 230000009286 beneficial effect Effects 0.000 description 1
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- 210000004369 blood Anatomy 0.000 description 1
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- 238000005266 casting Methods 0.000 description 1
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- 239000012153 distilled water Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229940097275 indigo Drugs 0.000 description 1
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
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- 239000012567 medical material Substances 0.000 description 1
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- 230000002265 prevention Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000036573 scar formation Effects 0.000 description 1
- 230000036560 skin regeneration Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000010913 used oil Substances 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
- G01N31/221—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating pH value
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- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
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Abstract
The present invention relates to a discolored hydrogel dressing material, which comprises a hydrogel dyed with a discoloration agent, and as the exudate of a wound is absorbed by the hydrogel, a color change is caused by a change in pH, and the replacement time of the dressing material can be easily grasped.
Description
The present invention relates to a discoloration hydrogel dressing material, more specifically, a discoloring agent that causes discoloration when a hydrogel is dyed with a discoloring agent to cause discoloration, thereby increasing the duration of the dressing material, The present invention relates to a hydrogel dressing material.
Treatment of wounds is a foundation of medicine and has a long history. According to Papyrus, 5000 years ago, it was reported that animals used oil, honey, and cotton for wound healing. Throughout history, many changes and developments have been made in the treatment of wounds. Since the publication of a study in 1962 by a zoologist Winter (Winter), which found that keeping wounds moist is more beneficial in healing than drying wounds and causing scabs, the usefulness of wet wounds Has been consistently proven and emphasized. A wet environment dressing method that prevents body fluid secreted from the wound from dehydrating or drying has now been found to facilitate wound healing.
Hydrogel is a treatment used for small wound healing. It has the effect of preventing bacterial invasion and preventing scarring by moistening the wound area. The advantages of wet dressing material compared to dry products are known as research results and the company's medical promotion. And marketing and market competition have intensified. In particular, the growth of the "wet colloidal" wet dressing agent, which is receiving the most attention in the market, is increasing remarkably. The wet dressing agent absorbs the natural healing substance to recover the wound quickly and prevents the scarring by preventing the scar formation. Therefore, there is a tendency that the number of users is increasing mainly around parents who have a high interest in beauty, Various types of sponges which can be used as medical materials have been developed by utilizing the biocompatibility, biodegradability, and antibacterial activity of the sponges.
The hydrogel can be used for the above purposes only when the hydrogel contains at least 60% moisture as a material used for the purpose of burn treatment or skin regeneration in which the wet state is continuously required. In the case of severe burn treatment, ultimately, autologous or transplanted tissue of the patient's fibroblasts in vivo is required. Since the above procedure requires a considerable amount of time, Prevention should be preceded. At this time, since the hydrogel has affinity with blood, body fluids and biotissues, it can be used as wound dressing. In addition, hydrogels can also be used for contact lenses and cartilage.
US Patent No. 5,389,376 discloses a method of manufacturing a dressing for wound healing using a radiation crosslinking method. The above-mentioned production method is carried out by mixing polyvinyl pyrrolidone with agar and polyethylene oxide and irradiating it with crosslinking. The above-described invention has an advantage of being able to simultaneously promote the characteristics of the crosslinking method of radiation, that is, crosslinking and sterilization. In addition, U.S. Patent No. 5,480,717 discloses a hydrogel prepared by casting a polyvinylpyrrolidone aqueous solution onto a polymer film having a pressure-sensitive adhesive and irradiating it with radiation.
On the other hand, human defense and recovery systems require several days to heal small wounds. The incision wound takes longer to heal and the infection progresses quickly. The dressing bandage covers the wound and protects against the bacteria, helps the hemostatic process and helps the recovery and regeneration of the damaged tissue, but the infection can occur due to the infiltration of the bacteria. Regularly changing the dressing to see if the wound is bleeding or infected can also make the wound worse by providing an opportunity for the bacteria to penetrate. Therefore, it is required to develop a new dressing material for monitoring bleeding, bacterial infection, and wound treatment without changing the dressing.
The conventional hydrogel dressing material turns white when absorbed moisture. However, it is difficult to judge whether or not the moisture is an exudate due to inflammation of the wound, and it is difficult to grasp the replacement time of the dressing material.
Accordingly, it is an object of the present invention to provide a dressing material comprising a hydrogel dyed with a discoloring agent which can change colors when absorbed exudates are absorbed in a hydrogel, and can detect a replacement time of a dressing material according to a color change.
It is another object of the present invention to provide a discoloration hydrogel dressing material which prevents secondary infections that may occur when a wound site is exposed to exudates and in which color change is conspicuously observed.
In order to achieve the above object,
The present invention provides a discolored hydrogel dressing material comprising a hydrogel dyed with a discoloring agent.
The color-changing hydrogel dressing material of the present invention can easily grasp the replacement timing of the hydrogel dressing material by using the phenomenon that the hydrogel is dyed with the discoloring agent and the exudate of the wound comes into contact with the color of the wound.
In addition, the color-changing hydrogel dressing material of the present invention can prevent secondary infections that may occur when the wound area is continuously exposed to the exudates, thereby effectively managing the wound.
In addition, the color-changing hydrogel dressing material of the present invention is economical and eco-friendly because of its simple manufacturing process.
Figure 1 is a photograph of a hydrogel dyed with a methyl orange dye.
2 is a photograph showing the color change in the acidity of the hydrogel dyed with methyl orange dye.
FIG. 3 is a photograph showing the color change in the basicity of the hydrogel dyed with methyl orange dye.
Figure 4 is a photograph of a hydrogel dyed with litmus dyes.
5 is a photograph showing the color change in the acidity of the hydrogel dyed with litmus dyes.
6 is a photograph showing the color change in the basicity of the hydrogel dyed with litmus dyes.
7 is a cross-sectional view of the discolored hydrogel dressing material.
Hereinafter, the present invention will be described in more detail.
The present invention relates to a discolorable hydrogel dressing material comprising a hydrogel dyed with a discoloring agent.
The color-changing hydrogel dressing material of the present invention provides a dressing material containing a hydrogel dyed with a discoloring agent, whereby a phenomenon that the exudation of wounds due to wound or burns and the hydrogel come into contact with each other, So that the degree of contamination at the wound site and the timing of replacement of the dressing material can be grasped objectively and easily.
In addition, since the color change is apparent, the replacement time can be easily determined, thereby preventing the possibility of bacterial infection that may occur during the replacement of the dressing material. In addition, secondary infections that may occur when wound sites are continuously exposed to exudates can be prevented.
In the present invention, the discoloring agent includes at least one selected from the group consisting of litmus dyes and methyl orange, and preferably includes a litmus dye.
Further, since the discoloring agent is used for a human body, it is preferable to use a discoloring agent having a pH of 4 to 9.
The hydrogel may be selected from the group consisting of agarose, polyethylene glycol (PEG), alginate salt, polyhydroxyethyl methacrylate (p) (HEMA), polyethylene oxide (PEO) ), Polyvinyl alcohol (PVA), polyacrylamide (PAA), and hyaluronic acid, and preferably includes agarose.
The hydrogel dyed with the discoloration agent can be prepared by mixing a hydrogel and an aqueous solution of a discoloration agent.
More specifically, the hydrogel may be prepared by mixing the aqueous solution of the discoloring agent and the hydrogel in an amount of 0.1 to 3% by weight, preferably 0.1 to 1.5% by weight, based on the total weight of the water.
When the discolorant is contained in an amount of less than 0.1% by weight, it is not leveled. When the discolorant is contained in an amount exceeding 3% by weight, the discolorant is not dissolved in water.
The hydrogel is mixed with 3 to 15% by weight, preferably 5 to 7% by weight, based on the total weight of the discoloration agent solution.
When the hydrogel is mixed in an amount of less than 3% by weight, undyed dyes remain in excess, and when the hydrogel is mixed in an amount of more than 15% by weight, the leveling agent does not occur.
The hydrogel may be prepared by adding water. However, in the present invention, by using the aqueous solution of the discoloration agent in place of water, the step of adding water and the step of dyeing can be performed at the same time, so that the manufacturing process can be simplified, thereby ensuring cost competitiveness.
The preparation of the discolored hydrogel dressing material by mixing the hydrogel and the aqueous solution of the discoloration agent is performed for 20 to 120 minutes and is performed at room temperature or at a temperature of 60 to 80 ° C, but the temperature range is not particularly limited.
In the present invention, by using a hydrogel dyed with a discoloring agent as a dressing material, exudate of a wound is absorbed by the hydrogel, and a color change appears, so that a replacement time of the dressing material can be easily grasped.
In addition, the color-changing hydrogel dressing material of the present invention can directly contact the skin, and can be used as such without additional constituents, and may contain additional constituents.
As the additional component, a transparent waterproof film having an adhesive strength may be laminated on the color-changing hydrogel dressing material. The type of the transparent waterproof film is not particularly limited, and a film used in the art can be used.
By using the hydrogel dyed with the discoloration agent in which the color changes in contact with the exudate as described above, the exudate is absorbed into the hydrogel dyed with the discoloration agent, and the hydrogel is changed in color by the pH of the exudate It is possible to easily determine whether or not the dressing material is replaced without opening the inside of the dressing material.
Hereinafter, the present invention will be described in more detail by way of examples. However, the following examples are intended to further illustrate the present invention, and the scope of the present invention is not limited by the following examples.
Discoloration hydrogel dressing remanufacturing
Example 1. Preparation of hydrogel dressing dyed with methyl orange dye
A methyl orange dye aqueous solution was prepared by adding 1% by weight of methyl orange dye to the total weight of water.
Agarose was added in an amount of 6% by weight based on the total weight of the aqueous solution of the methyl orange dye, and the mixture was heated to 70 ° C. and mixed at a temperature of 70 ° C. for 30 minutes. The mixture was cooled to room temperature and washed with distilled water. To prepare a dyed hydrogel (Fig. 1).
As a result of checking the discoloration of the hydrogel, it was confirmed that it changed from acid to dark red (FIG. 2) and from basic to dark orange (FIG. 3).
Example 2. Preparation of dyed hydrogel dressing with litmus dyes
The procedure of Example 1 was repeated except that a litmus dye was used instead of the methyl orange dye to prepare a dyed hydrogel (Fig. 4).
As a result of checking the discoloration of the hydrogel, it was confirmed that the color changed from acid to red (FIG. 5) and from basic to indigo (FIG. 6).
Generally, since exudates of wounds exhibit a pH of from 6 to 9, when the discolored hydrogel dressing material of the present invention is used, exudates are absorbed into the hydrogel, .
Therefore, it is possible to prevent the occurrence of a new disease caused by the secondary infection because the infected bacteria and the body can not recognize the inflammation resulting from the immune function of the wound and miss the replacement time.
Claims (8)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020150170723A KR102007064B1 (en) | 2015-12-02 | 2015-12-02 | A wound hydrogel dressing substance with discoloring function |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020150170723A KR102007064B1 (en) | 2015-12-02 | 2015-12-02 | A wound hydrogel dressing substance with discoloring function |
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| KR20170064799A true KR20170064799A (en) | 2017-06-12 |
| KR102007064B1 KR102007064B1 (en) | 2019-08-02 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5389376A (en) | 1991-11-15 | 1995-02-14 | Minnesota Mining And Manufacturing Company | Pressure-sensitive poly(n-vinyl lactam) adhesive composition and skin covering articles using same |
| US5480717A (en) | 1992-12-15 | 1996-01-02 | Johnson & Johnson Consumer Products, Inc. | Hydrogel laminate bandages and composites |
| JP3009921B2 (en) * | 1989-11-28 | 2000-02-14 | イー・アール・スクイブ・アンド・サンズ・インコーポレイテッド | Bandage with indicator |
| JP2001515762A (en) * | 1997-09-05 | 2001-09-25 | ティー ジー イーキン リミテッド | Wound dressing |
| JP2007520694A (en) * | 2003-11-22 | 2007-07-26 | エイジーティ サイエンシズ リミテッド | Polymer material containing pH indicator dye |
| KR20090086597A (en) * | 2006-12-14 | 2009-08-13 | 킴벌리-클라크 월드와이드, 인크. | Skin coating with microbial indicator |
| KR20120044970A (en) * | 2009-07-15 | 2012-05-08 | 킴벌리-클라크 월드와이드, 인크. | Color-changing materials and multiple component materials having a color-changing composition |
| JP2014526314A (en) * | 2011-09-08 | 2014-10-06 | インディケーター システムズ インターナショナル， インコーポレイテッド | Wound care compositions and devices activated by infection |
| KR20150033237A (en) * | 2013-09-24 | 2015-04-01 | 경상대학교산학협력단 | Hydrogel patch for wound healing and monitoring |
| KR20150072129A (en) * | 2013-12-19 | 2015-06-29 | 주식회사 원바이오젠 | A wound dressing substance with discoloring function and its manufacturing method |
-
2015
- 2015-12-02 KR KR1020150170723A patent/KR102007064B1/en active IP Right Grant
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3009921B2 (en) * | 1989-11-28 | 2000-02-14 | イー・アール・スクイブ・アンド・サンズ・インコーポレイテッド | Bandage with indicator |
| US5389376A (en) | 1991-11-15 | 1995-02-14 | Minnesota Mining And Manufacturing Company | Pressure-sensitive poly(n-vinyl lactam) adhesive composition and skin covering articles using same |
| US5480717A (en) | 1992-12-15 | 1996-01-02 | Johnson & Johnson Consumer Products, Inc. | Hydrogel laminate bandages and composites |
| JP2001515762A (en) * | 1997-09-05 | 2001-09-25 | ティー ジー イーキン リミテッド | Wound dressing |
| JP2007520694A (en) * | 2003-11-22 | 2007-07-26 | エイジーティ サイエンシズ リミテッド | Polymer material containing pH indicator dye |
| KR20090086597A (en) * | 2006-12-14 | 2009-08-13 | 킴벌리-클라크 월드와이드, 인크. | Skin coating with microbial indicator |
| KR20120044970A (en) * | 2009-07-15 | 2012-05-08 | 킴벌리-클라크 월드와이드, 인크. | Color-changing materials and multiple component materials having a color-changing composition |
| JP2014526314A (en) * | 2011-09-08 | 2014-10-06 | インディケーター システムズ インターナショナル， インコーポレイテッド | Wound care compositions and devices activated by infection |
| KR20150033237A (en) * | 2013-09-24 | 2015-04-01 | 경상대학교산학협력단 | Hydrogel patch for wound healing and monitoring |
| KR20150072129A (en) * | 2013-12-19 | 2015-06-29 | 주식회사 원바이오젠 | A wound dressing substance with discoloring function and its manufacturing method |
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| KR102007064B1 (en) | 2019-08-02 |
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