KR20170053072A - Children toothpaste containing extracts from lentinula edodes - Google Patents

Abstract

According to the present invention, a toothpaste for kids containing an extract of Lentinula edodes comprises: a sweetener comprising xylitol as an additive; a foaming agent comprising sodium lauryl sulfate as an additive; a preservative comprising potassium sorbate as an additive; a moisturizer comprising at least one of an amorphous sorbitol solution (70%), polyethylene glycol 1500, and glycerin as an additive; an abrasive agent comprising silicon dioxide as an additive; a solvent comprising purified water as an additive; a suspension comprising carboxymethylcellulose sodium (CMC-Na) as an additive; a viscosity regulator comprising chitosan as an additive; a flavoring agent comprising at least one of enzymatically modified stevia glucosyl stevia and pineapple flavor EM988 as additives; an antibacterial agent comprising at least one of allantoin chlorohydroxyaluminum and aminocaproic acid as additives; and an antioxidant agent comprising at least one of ascorbic acid and the extract of Lentinula edodes as additives.

Description

{CHILDREN TOOTHPASTE CONTAINING EXTRACTS FROM LENTINULA EDODES}

More particularly, the present invention relates to a toothpaste for children, which comprises a white flour extract, and more particularly, to an improvement of skin diseases, an increase in immunity such as anticancer, a prevention of oral bacteria growth, occurrence of periodontal disease and dental calculus, And to minimize the rejection reaction when the toothbrush is wiped so as to conform to the symbol.

The mouth of the human body is the entrance of the digestive tract, which is digested by the action of the lower jaw, the action of the teeth, chewing the food by cooperating with the ball, tongue and lips, and mixing the needles with food to decompose the starch into starch digestive enzymes The food is delivered to the esophagus, the mouth makes sound, and the taste acts to taste the food.

In the mouth of the human body, the tongue which helps the taste of the food and the organs of the food, and the tooth which breaks and breaks the food by the chewing and cutting is surrounded by the upper and lower periodontal bone (gum bone). However, due to the remaining of the ingested material, In addition to oral bacteria, many bacteria are known to cause inflammation. One of these bacteria is Helicobacter pylori, which is known as a cause of gastritis, gastric ulcer and gastric cancer. It has been reported in the academia that it is resident in the stomach and oral cavity by vomiting and vomiting.

In addition, diseases that can occur in teeth include tooth decay and periodontal disease, which are caused by oral microorganisms such as Streptococcus mutans, Lactobacillus, E. coli, and the like , The microorganisms decompose sugars to form insoluble glucan. These are attached to the surface of teeth together with various microbes to form tartar. The microorganisms attached to these calculi decompose sugar to dissolve the etamer layer on the surface of the teeth The tooth cavity is generated, and the discomfort is dissolved by the body of the bacteria, and periodontal disease occurs.

As such, the mouth (oral cavity and teeth, periodontal bone) is a state of cleansing only the inhibition of the activity of microorganisms in the oral cavity. In order to maintain the cleanliness of the oral cavity for a long time, microorganisms There is a desperate need to develop dentifrice compositions that control activity and inhibit bacterial growth.

In addition, the development of dentifrice compositions is suitable for the development of dentifrice compositions, especially for children who tend to have a tendency to cause a rejection reaction to mouthwashes, to improve skin diseases, to increase immunity such as anticancer drugs, to increase oral bacteria, There has been a problem in that a toothpaste satisfying this requirement can not be developed.

Korean Patent Publication No. 10-2010-0080295

The object of the present invention is to provide a method for improving the skin diseases and improving the immunity such as anti-cancer, inhibiting the growth of oral bacteria, gum disease and dental calculus, And to provide a child toothpaste containing the extract of Bacillus subtilis, which minimizes the reaction.

In order to accomplish the above object, the present invention provides a toothpaste for children, comprising: a sweetener comprising xylitol as an additive; Foaming agents using sodium lauryl sulfate as an additive; A preservative containing potassium sorbate as an additive; Amorphous sorbitol solution (70%), polyethylene glycol 1500, a wetting agent containing at least one of glycerin as an additive; An abrasive containing silicon dioxide as an additive; A solvent containing purified water as an additive; A suspension containing sodium carboxymethylcellulose (CMC-Na) as an additive; Viscosity modifiers comprising chitosan as an additive; Enzymatic treatment Stevia, Flavoring agent containing at least one of Pineapple flavor EM988 as an additive; An antibacterial agent comprising at least one of allantoin chlorohydroxyaluminum and aminocaproic acid as an additive; And ascorbic acid, and an antioxidant comprising at least one of the extracts of white flour as an additive.

The present invention provides a technical effect that minimizes the rejection reaction when the toothbrush is adapted to the taste of young children, thereby increasing the immunity such as improvement of skin diseases and anti-cancer, inhibiting the growth of oral bacteria, have.

Hereinafter, specific embodiments of the present invention will be described in detail.

The toothpaste according to the present invention includes a sweetener, a foaming agent, a preservative, a wetting agent, an abrasive, a solvent, a viscosity controlling agent, a flavoring agent, an antimicrobial agent, an antioxidant and a suspending agent which are generally used as a dentifrice composition.

Each of the dentifrice compositions used in the present invention, purpose of blending, amounts used and the like will be described in detail below.

In the present invention, xylitol was used, but the present invention is not limited to this, and it is possible to use salmeterol such as saccharin, sucralose, sugar, sorbitol, lactose, mannitol, maltitol , Erythritol, aspartame, taurine, saccharin salt, D-tryptophan, and the like. The amount of the sweetener may be in the range of 0.001 to 20% by weight based on the total weight of the dentifrice composition.

The foaming agent improves the feel of the product, helps the cleansing action, accelerates the dispersion and penetration of other active ingredients, and reduces interfacial tension, thereby easily releasing foreign substances in the oral cavity. In the case of the present invention, sodium lauryl sulfate But not limited to, sodium alkyl sulfate, alkyl salicosinate, lauryl sulfate, cocoyl glutamate sodium salt, myristoyl glunamate sodium salt, cocamidopropyl betaine, sucrose fatty acid The anionic, amphoteric and nonionic surfactants such as ester, sorbitan fatty acid ester and copolymer of polyoxyethylene polyoxypropylene (poloxamer) can be used alone or in combination of two or more. The amount of foaming agent used is generally 0.2 to 5% by weight, based on the total weight of the dentifrice composition, 3.5% by weight.

The preservative is a substance for inhibiting the growth of bacteria to prevent the decay and deterioration of the food. In the present invention, potassium sorbate is used as a preservative. However, the preservative is not limited to this, but p-oxybenzoic ester, benzoic acid, sodium benzoate, The amount of the preservative to be used is 0.05 to 0.2% by weight, preferably 0.1 to 0.2% by weight based on the total weight of the dentifrice composition.

The wetting agent is an essential ingredient for making ointment formulations. It prevents the toothpaste from drying and solidifying when the toothpaste is exposed to the air, and provides a luster on the surface of toothpaste, and also provides a sweetening effect when brushing according to the kind. (70%), polyethylene glycol 1500 and glycerin were used as the wetting agent, but not limited thereto, hyaluronic acid, sorbitol, ethylene glycol, propylene glycol, polypropylene glycol and the like can be used. By weight, or 20 to 60% by weight, preferably 20 to 50% by weight, of a mixture of two or more thereof.

In the present invention, silicon dioxide is used as an abrasive in the present invention, but the present invention is not limited to this, and examples of the abrasive include calcium monohydrogenphosphate, precipitated silica, fumed silica, colloidal silica, Zeolite, calcium carbonate, hydrated alumina, kaolin, cellulose, and mixtures thereof. The amount of the abrasive to be used is in the range of 0.1 to 30% by weight based on the total weight of the dentifrice composition, 20% by weight.

In this case, if the content of the abrasive is less than 0.1% by weight, the toothpaste will not exhibit a cleansing power because it does not exhibit a polishing degree, and if it exceeds 30% by weight, sufficient washing power can not be obtained compared with the content, have.

In the present invention, purified water is used. However, it is not limited to this and organic solvents such as ethanol may be used. The amount of the solvent to be used is 1 to 90% by weight based on the total weight of the dentifrice composition, Preferably in an amount of 10 to 60% by weight.

The viscosity controlling agent is a component that increases or decreases the viscosity of the final product. The viscosity controlling agent is important for the stability, texture and usability of the product. The viscosity controlling agent may be divided into a viscosity increasing agent and a viscosity reducing agent. In the present invention, chitosan is used as a viscosity controlling agent. Carboxymethyl cellulose, Xanthan gum and the like can be used. The amount of the viscosity controlling agent to be used is 0.1 to 10% by weight, preferably 0.3 to 4% by weight, based on the total weight of the dentifrice composition. It can be used in quantities.

Flavoring agents are constituents of fragrances such as aromatic chemicals, essential oils, natural extracts, distillates, isolates, aromas, resinous resins and the like. In the case of the present invention, natural flavorings such as enzyme-treated stevia, pineapple flavor EM988, and the amount of the flavoring agent to be used may be in the range of 0.001 to 10% by weight based on the total weight of the dentifrice composition.

In this case, it is preferable to use fruit flavoring agents such as strawberry, peach, apple, banana and melon in addition to enzyme treatment stevia and pineapple EM988 as a flavoring agent to suit children's preferences. The use of flavorings that give the same flavor can cause a decrease in the preference of young children.

The antimicrobial agent is used not only to alleviate the gum disease that is progressing through sterilization or anti-inflammatory action to the harmful microorganisms living in the oral cavity, but also to prevent gum disease in advance. In the present invention, allantoin chlorohydroxy aluminum Aminocaproic acid is used, but the present invention is not limited thereto. Isopropylmethylphenol, cyclohexidine, cetylpyridinium chloride, triclosan, xanthorrhizone, and zucchini extract may be used. The amount of the antibacterial agent may be in the range of 0.1 to 1.0% by weight, preferably 0.1% by weight, more preferably 0.1 to 1% by weight, based on the total weight of the dentifrice composition. It can be used in quantities.

In this case, allantoin chlorohydroxyaluminum and aminocaproic acid increase oral delivery and residual effect, effectively suppressing the formation of plaque and ultimately, exert an excellent effect in inhibiting the growth of oral bacteria, occurrence of periodontal disease and formation of tartar These amounts are preferably used in an amount of 0.1% by weight based on the total weight of the dentifrice composition. If the concentration of the dentifrice composition is below the concentration range, the effect is insignificant. And the usability of the composition is poor.

The antioxidant acts on the free radicals and peroxides generated in the oxidation process of food components by oxygen in the air to stop the chain reaction of oxidation and prevent the progress of oxidation and to prevent the degradation of food, In order to prevent discoloration and toxicity, ascorbic acid and white flour extract are used as antioxidants in the present invention. The amount of the active ingredient to be used may be 0.1 to 1.0% by weight based on the total weight of the dentifrice composition.

Hereinafter, the efficacy, production method and extraction method of the present invention as a feature of the present invention will be described in detail.

The dental composition of the present invention contains a large amount of proteins, various amino acids, vitamin B, vitamin D and minerals, and helps to prevent skin aging through antioxidative action to remove active oxygen promoting skin aging Atopic dermatitis, acne and inflammation, eczema and skin diseases such as redness and anti-cancer, antitumor polysaccharide Lentinen, which contains the substance to increase immunity, cancer cells to prevent the proliferation of high blood pressure and anti-cancer effect It is also known that vitamin B1, B2 and vitamin D ergosterrine are contained in large amounts to strengthen the bones and promote absorption of calcium and phosphorus.

1. Mushroom production method

(1) After oak crushing,

(2) Inoculation of seed after seeding (work around September)

(3) browning

    It takes about 120 days to mature the seed to spread evenly on the oak medium.

(4) Standing

It takes 30 days to win after 24 hours of inundation, 3 days after 35 days, and 3 days after inundation.

(5) After production, it is dried in natural sunlight for 3 days, dried in a dryer and stored

2. Mushroom Extract Method

(1) Dust of dry baggage is cleaned

Although the flora can be used both as a living thing and as a dried one, the water content can be adjusted to less than 10%, for example, through drying because the dry bleaching flour is more effective than the living thing.

 (2) The dried white flour is put into a heavy steam pressure tank, and 12 kg of white flour is added to 150 L of water, followed by heating. In this case, heating is carried out at 0 to 80 ° C. for 1 hour, at 80 to 100 ° C. for 1 hour, After heating for 1 hour, the main component of the flour is hydrothermally extracted.

(3) After extracting the hot water, the extract is separated and kept at 80 ℃ or higher. It is stored at 18 ℃. In this case, care should be taken that the longest extract does not exceed 3 months.

(4) Extracted extracts of Baekhwago were prepared on the same day when the toothpaste was prepared.

Finally, the suspending agent is a suspending agent in which a suspending agent, purified water or oil is added to a solid product and functions to prevent the solid product from being deposited. In the case of the present invention, sodium carboxymethyl cellulose (CMC-Na But it is not limited thereto, and it is possible to use gum arabic, tragacanth, methylcellulose (MC), sodium arginate, etc. The amount of the suspension to be used may be 0.1 to 2.0% by weight based on the total weight of the dentifrice composition .

Table 1 below shows examples of composition, purpose of blending, and content of a toothpaste for children containing the extract of Tetranyba radci according to the present invention.

With reference to Table 1, the main features of the toothpaste for children containing Brassica napus extract according to the present invention will be summarized.

First, in the toothpaste of the present invention containing the extract of Brassica oleracea according to the present invention, 1.0 wt% of the Brassica oleracea extract obtained from the above-described method of producing 1. mushroom and 2. mushroom extract according to the present invention is used (Through comparison of Examples 1 and 2 and Example 1), it exhibits an excellent effect of increasing immunity such as skin disease improvement and anti-cancer.

Second, the toothpaste according to the present invention containing the extract of Brassica oleracea according to the present invention is prepared by using 0.1 wt% of a non-ionic antimicrobial agent such as allantoin chlorohydroxyaluminum and aminocaproic acid as the antibacterial agent in the total weight of the dentifrice composition (Comparative Examples 1 and 2 And through comparison of Example 1), it exhibits an excellent effect of effectively inhibiting the formation of plaque by increasing the oral delivery and residual effect, ultimately inhibiting the growth of oral bacteria, the occurrence of periodontal disease and the formation of periodontal disease, Feature.

Third, in the toothpaste for children's use according to the present invention, enzyme-treated stevia was used as a flavoring agent in an amount of 0.3 wt% based on the total weight of the dentifrice composition, and pineapple flavor EM988, % (Through comparison of Comparative Examples 1 and 2 and Example 1), it exhibits an excellent effect of minimizing the rejection reaction when garnishing it in accordance with the taste of young children.

While the present invention has been described in connection with what is presently considered to be the most practical and preferred embodiment, it is to be understood that the invention is not limited to the disclosed embodiments. It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit of the invention.

Claims (3)

A sweetening agent containing xylitol as an additive;
Foaming agents using sodium lauryl sulfate as an additive;
A preservative containing potassium sorbate as an additive;
Amorphous sorbitol solution (70%), polyethylene glycol 1500, a wetting agent containing at least one of glycerin as an additive;
An abrasive containing silicon dioxide as an additive;
A solvent containing purified water as an additive;
A suspension containing sodium carboxymethylcellulose (CMC-Na) as an additive;
Viscosity modifiers comprising chitosan as an additive;
Enzymatic treatment Stevia, Flavoring agent containing at least one of Pineapple flavor EM988 as an additive;
An antibacterial agent comprising at least one of allantoin chlorohydroxyaluminum and aminocaproic acid as an additive; And
Ascorbic acid, and white flour extract, and an antioxidant containing at least one of the extracts. [3] The method of claim 1,
It is obtained by adding 12kg of dried white rice flour to 150L water and then heating it at 0 ~ 80 ℃ for 1 hour, followed by secondary heating at 80 ~ 100 ℃ for 1 hour and third heating at 100 ~ 114 ℃ for 1 hour. Tobacco extracts. [3] The composition of claim 2,
Wherein the toothpaste composition comprises 0.1 to 1.0 part by weight based on the total weight of the dentifrice composition.