KR20170021573A - External use sanitizers containing hinoki cypress leaf extract and lemon leaf extract and manufacturing method of the same - Google Patents
External use sanitizers containing hinoki cypress leaf extract and lemon leaf extract and manufacturing method of the same Download PDFInfo
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- KR20170021573A KR20170021573A KR1020150116131A KR20150116131A KR20170021573A KR 20170021573 A KR20170021573 A KR 20170021573A KR 1020150116131 A KR1020150116131 A KR 1020150116131A KR 20150116131 A KR20150116131 A KR 20150116131A KR 20170021573 A KR20170021573 A KR 20170021573A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/882—Acoraceae (Calamus family), e.g. sweetflag or Acorus calamus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
Abstract
The present invention relates to a disinfectant for external use containing an extract of Leafy white leaf and lemon leaf as an active ingredient, and a method for producing the disinfectant, Crushing the dried monocotyledonous leaves and lemon leaves, respectively; Extracting the crushed soft white leaves and lemon leaves respectively; Filtering the leek leaf extract and lemon leaf extract, respectively; Concentrating the filtered leek leaf extract and lemon leaf extract, respectively; And a step of mixing and stirring the concentrated albino leaf extract and lemon leaf extract, followed by addition of alcohol and alcohol, and an external disinfectant containing the albino leaf extract and lemon leaf extract as an active ingredient, And a method for producing the same.
The external disinfectant according to the present invention not only has irritating odor but also is not sticky, contains antibacterial effect by containing Leaf Leaf Extract, and contains lemon leaf extract, It has the ability to neutralize the alcohol odor of the disinfectant by incense.
Description
The present invention relates to a disinfectant for external use containing an extract of Leafy white leaf and lemon leaf as an active ingredient, and a method for producing the disinfectant, Crushing the dried monocotyledonous leaves and lemon leaves, respectively; Extracting the crushed soft white leaves and lemon leaves respectively; Filtering the leek leaf extract and lemon leaf extract, respectively; Concentrating the filtered leek leaf extract and lemon leaf extract, respectively; And a step of mixing and stirring the concentrated albino leaf extract and lemon leaf extract, followed by addition of alcohol to the alcohol, and mixing and stirring. The external disinfectant containing the albino leaf extract and lemon leaf extract as an active ingredient, And a method for producing the same.
The external disinfectant according to the present invention not only has irritating odor but also is not sticky, contains antibacterial effect by containing Leaf Leaf Extract, and contains lemon leaf extract, It has the ability to neutralize the alcohol odor of the disinfectant by incense.
As many people interact with each other, many infectious diseases from various bacterial infections and carriers spread easily around.
Infection refers to a condition in which a pathogenic microorganism invades and proliferates within a host and causes a destructive effect on the host. The infectious agent including infectious agents, infectious agents, infectious animals, , The pathway for the entry of pathogens into living organisms directly or indirectly from these infectious agents is called the infection path.
Infection pathways include air infections, oral infections, and transdermal infections. Air infections refer to infections caused by adventitious agents that adhere to the mucous membranes of skin or respiratory organs. Airborne infections enter the digestive system through mouths Refers to an infection that occurs when a pathogen enters the skin through the skin.
Most infectious diseases are more likely to be infected by damaging hands with bacteria, eyes, nose, and mouth rather than infecting them directly into the nose or mouth through the air.
The hand is the primary site of contact with harmful bacteria among the body parts, and it can prevent infectious diseases by using external disinfectant.
Recently, various external disinfectants have been developed as the importance of the use of external disinfectants has been emphasized as a means for preventing infectious diseases.
The disinfectants for external use, which are controlled by quasi-drugs, are used to sterilize various pathogenic bacteria including food poisoning bacteria. The main components are ethanol, isopropyl alcohol, hydrogen peroxide, benzalkonium chloride, (cresol) and the like.
External disinfectants may be classified as external disinfectants containing denatured alcohol and external disinfectants containing ethanol depending on the main constituents contained therein. External disinfectants containing denatured alcohol containing a strong odor modifier have a high odor when used There are disadvantages.
Modified alcohols are compounds that are toxic or odorous as a modifier in alcohol to prevent the ingestion of industrial alcohols. Many compounds such as methanol, benzene, and benzine are used as modifiers. do.
In addition, the external disinfectant may be classified into a gel, a solid, and a liquid type according to the formulations to be manufactured. The gel-type external disinfectant may be prepared by adding a thickening agent such as Carbopol Pre-Gel to increase the viscosity, There is a disadvantage that there is a lot of stickiness in use, and a solid type external disinfectant is manufactured in the form of soap by adding a surfactant. It is inconvenient to wash with water due to the surfactant component, There is a drawback.
Accordingly, development of an external disinfectant containing ethanol as a main component which does not give off a strong smell when using external disinfectants, and which is made into a liquid type which does not need to be tacky and washed with water, and has a moisturizing effect is desired to be developed.
Therefore, the present inventors have found that not only the irritating odor is caused by using alcohol alcohol (ethanol) but also it is not sticky, contains antibacterial effect by containing Leaf Leaf Extract, has excellent moisturizing effect by containing lemon leaf extract, A disinfectant for external use capable of neutralizing the smell of alcohol in the incense, and a manufacturing method thereof.
Hereinafter, the manure and lemon used as the material of the present invention will be briefly described below.
Cloning ( Chamaecyparis obtusa ) is an evergreen arborescent tree, and it is also called ashiko, hinoki and cypress.
It is 30 ~ 40m in height and 1 ~ 2m in width. The bark is reddish brown, and small needle-shaped leaves are densely grown on branches.
It is distributed in Japan and southern part of Korea. It contains γ-cadinene, α-terpineol and borneol, and leaves and wood contain 1% essential oil. .
It has a strong antimicrobial action that improves skin conditions, calms the itch, and prevents bacteria from penetrating into the skin.
In addition, the whitening of the body to produce antibodies to the antigen to improve the body's ability to protect the body from various diseases.
Citrus limon is an evergreen tree with horns and grows relatively cool, without climatic changes, and is cultivated much in Italy, España, California, USA and Australia.
The height is 3-6 m. The leaves are red when they are young, but gradually become green.
Because it contains a lot of vitamin C and citric acid is strong. Lemon oil is used as a raw material for drinks, perfumes and lemonade in the skin, and the juice is used as a raw material for beverages, vinegar and cosmetics. It is also used as a fragrance when making confectionery.
Lemon works to replenish the water. When the body lacks water, it is effective to replenish the moisture by taking the juice of lemon. This moisturizing effect is widely used in cosmetics such as packs and creams for moisturizing the skin.
Also, the ingredients such as limonin and citral contained in the lemon peel act to remove the body odor, so lemon is widely used for fragrance and deodorant.
The prior art related to the present invention is disclosed in Korean Patent Laid-Open Publication No. 10-2001-0013210 (Prior Art 1), which discloses a disinfectant composition and a method of disinfecting the surface thereof, and Korean Patent Publication No. 10-2000-0023826 (Prior art 2) discloses surfactants, chelating agents and aroma oil formulations for use in effective disinfection.
The present invention relates to an antiobesity agent, an antimicrobial essential oil, or an active ingredient thereof, or a mixture thereof, to provide a sustained disinfecting power. The antimicrobial essential oil contains lemon oil and hinokitiol (hinokitiol) is included.
The present invention relates to an antimicrobial composition which can be used in the disinfection and washing or washing fields of various surfaces including hard surfaces and includes antimicrobial fragrance oil contained in the antimicrobial composition and lemon and hinokitiol, .
Prior art documents contain the linoleum and lemon used in the present invention, but contain only hinokitiol among the various functional ingredients contained in the linen.
Hinokitiol is an essential oil component contained in cotton wool, and is a functional ingredient with strong antifungal, antibacterial, deodorant and insecticidal effects. Hinokitiol contains a large amount of phytoncide, a natural antimicrobial substance, which is used as a natural preservative because of its excellent antibacterial and bactericidal action.
The present invention relates to a disinfectant for external use containing a cottonseed extract obtained by extracting a cottonseed from a cottonseed oil by a steam distillation method and mixing the cottonseed oil with an optimal mixing ratio, and unlike the prior literature containing only a hinokitiol, .
The main components of essential oil are dl-limonene,? -Terpinene, borneol,? -Terpinene,? -Myrcene, Monoterpene, such as terpinolene, terpineol, 2-carne, and a-pinene, accounting for about 80% of the total content.
In addition, since the water-soluble phytoncide is contained in a large amount in the untreated water, it has excellent antibacterial and bactericidal action.
That is, the efficacy in the prior literature containing only hinokitiol in the unilamellar oil is not limited to the hinokitiol, but also to the whitening oil containing the various functional ingredients other than the hinokitiol and the maleic anhydride containing the large amount of the water-soluble phytoncide Can not reach the efficacy of.
An object of the present invention is to provide a topical disinfectant containing softener Leaf Leaf Extract and Lemon Leaf Extract, which are excellent in antimicrobial effect by using a natural antimicrobial agent, as an active ingredient, and a method for producing the same.
The present invention relates to a method for producing a starch, Crushing the dried monocotyledonous leaves and lemon leaves, respectively; Extracting the crushed soft white leaves and lemon leaves respectively; Filtering the leek leaf extract and lemon leaf extract, respectively; Concentrating the filtered leek leaf extract and lemon leaf extract, respectively; And a step of mixing and stirring the concentrated albino leaf extract and lemon leaf extract, followed by addition of alcohol to the alcohol, and mixing and stirring. The external disinfectant containing the albino leaf extract and lemon leaf extract as an active ingredient, And a method for producing the same is provided.
The external disinfectant according to the present invention not only has irritating odor but also is not sticky, contains antibacterial effect by containing Leaf Leaf Extract, and contains lemon leaf extract, It is intended to solve the technical problem by providing the effect of neutralizing the alcohol odor of the disinfectant by incense.
The external disinfectant containing the extract of Leaf Leaf Leaf and Lemon Leaf Extract according to the present invention is not only irritating odor but also non-sticky by using alcohol alcohol, has antimicrobial effect by containing Leaf Leaf Extract, It has an excellent ability to moisturize and to neutralize the alcohol odor of disinfectant with lemon fragrance by containing leaf extract.
1 is a flowchart showing a preferred embodiment of a disinfectant for external use and a method for producing the disinfectant according to the present invention, which contains an extract of Leptin Leaves and Lemon Leaf Extract as an active ingredient.
The terms and words used in the present specification and claims should not be construed as limited to ordinary or dictionary terms and the inventor may properly define the concept of the term in order to best describe its invention It should be construed as meaning and concept consistent with the technical idea of the present invention.
Therefore, the experimental examples and the reference examples described in the present specification are merely the most preferred embodiments of the present invention and are not intended to represent all of the technical ideas of the present invention. Therefore, various equivalents and variations Examples should be understood.
Example 1. Preparation of external disinfectant containing leek leaf extract and lemon leaf extract
1) drying step
Prepare leek leaves and lemon leaves.
Edamame, essential oil, fruit and leaves may be used for the leek, and a leaf part preferably containing a large amount of the functional ingredient may be used.
Lemons can be used as branches, fruits and leaves, preferably leaf parts containing a large amount of functional ingredient.
The untreated leaves and lemon leaves may be dried using various drying methods such as natural drying, hot air drying, cold air drying, far infrared drying, electric drying, freeze drying or microwave drying, but a cold air drying method may be used.
Drying of cold air prevents the components contained in temperate and lemon leaves from being easily volatilized at high temperatures, and the efficiency of extracting white and lemon leaves can be increased.
Cold air drying can be carried out at 10 to 40 ° C for 1 to 5 days, and can be controlled depending on the moisture content of cotton leaf and lemon leaf.
2) Grinding step
The dried monocotyledonous leaves and lemon leaves are each ground.
Crushing can be carried out using a rotary crusher, a jaw crusher, a roll crusher, a cone crusher, a hammer crusher, an impact crusher, a hammer mill A rod mill, a ball mill, a Raymond mill, a super mill, a roll mill, a pin mill, a jet mill, a Konica ball mill A conical ball mill, a vibration mill or the like.
The pulverization can be carried out with a size of 1 to 100 mesh, and can be variously set according to design conditions.
Also, the grinding step can be repeatedly applied at least twice according to the design conditions.
Through the above process, the extraction efficiency is increased at the subsequent extraction stage.
3) Extraction step
The crushed white flakes are extracted.
Various extraction methods such as a supercritical fluid extraction method, a steam distillation method, a vacuum extraction method, a depressurization extraction method, a microwave process extraction method, and a percolation extraction method may be used, but a steam distillation method may be preferably used.
Steam distillation is the process of distilling the white flakes through water vapor to collect the functional ingredients of the white flakes. First, the white flakes are fed with steam and compressed air.
The pressure range of the steam supplied to obtain the extract of the curd refuse containing a lot of functional ingredients in the supply of steam and compressed air can be adjusted from 2.0 to 4.0 kgf / cm 2 and the pressure range of the compressed air supplied is 1.0 to 3.0 atm Lt; / RTI >
Steam and compressed air lead to the distillation of the flock, which causes the various functional components contained in the flock to flow out together with the water vapor.
Condensate is generated by cooling and condensing the water vapor that comes out along with the various functional components of the white yarn.
From the condensed water resulting from the condensation of water vapor, centrifugal separation is performed to extract the untranslated water and the untranslated oil separated into layers.
The extracts of the albino leaf can be obtained by mixing the extracted albino water and the albino oil.
At this time, the mixing ratio of the extracted untreated water and the unbleached oil may be 1:20 to 80, preferably 1:60.
Extract the crushed lemon leaves.
Extraction can be performed by various extraction methods such as supercritical fluid extraction, steam distillation, vacuum extraction, vacuum extraction, microwave process extraction, and percolation extraction. Preferably, supercritical fluid distillation can be used have.
In the supercritical fluid extraction method, carbon dioxide can be used as a supercritical substance. Since carbon dioxide is easily accessible to critical conditions and is not only harmless to human body but also incombustible, chemically stable and has a low critical temperature, it causes deterioration of solute component It is suitable for extracting pharmaceuticals and foods and is widely used as supercritical extraction solvent.
In the supercritical fluid extraction, a mixed solvent in which other solvent is mixed may be used in addition to carbon dioxide, which is a supercritical fluid, and at least one of ethanol, methanol, ethyl acetate and water is used as the solvent .
The extraction can be carried out at a temperature of 30 to 50 DEG C and a pressure of 100 to 350 bar for 20 to 300 minutes.
4) Filtration step
Leaf leaf extract and lemon leaf extract are each filtered.
Filtration can be carried out by various methods such as chromatography, suction filtration, atmospheric filtration, vacuum filtration, pressure filtration, ultrafiltration, microfiltration and reverse osmosis, depending on design conditions.
The filtration time, temperature, and the number of times may also be varied depending on the design conditions. Filtration can be performed using a method other than the filtration method described above, or using two or more methods.
5) Concentration step
The filtered cottonseed leaf extract and lemon leaf extract are each concentrated.
Concentration can be performed by methods such as evaporation concentration, freeze concentration, dry concentration, membrane concentration, vacuum concentration, and concentration under reduced pressure. It may also be concentrated using more than one method.
Preferably under reduced pressure, and can be carried out for 2 to 5 hours.
6) Mixing and stirring step
After mixing the concentrated Leaf Leaf Extract and Lemon Leaf Extract, the alcohol is added and mixed.
At this time, the blending ratio of the mixture in the mixing step is preferably 20 to 40 parts by weight of the leek leaf extract and 60 to 80 parts by weight of the alcohol alcohol, based on 0.01 to 3 parts by weight of the lemon leaf extract.
An appropriate amount of distilled water can be added depending on the design conditions.
In addition, a moisturizing agent may be added to enhance the moisturizing effect. The moisturizing agent may be selected from the group consisting of isopropyl myristate, propylene glycol, glycerin, silicone derivatives, aloe vera, At least one selected from the group consisting of sorbitol, glycerin fatty acid ester and sodium hyaluronate may be used.
The mixing ratio of the added humectant is preferably 0.01 to 3 parts by weight based on 0.01 to 3 parts by weight of lemon leaf extract.
In addition, antimicrobial agents can be added to enhance antimicrobial activity. Antimicrobial agents can be added to the antimicrobial agents such as antioxidant extract, anthelmintic extract, seokchonpo extract, At least one selected from the group consisting of an extract, a rhizome extract, a rosemary extract, a moxa extract, a dandelion extract, a pine needles extract and a Guji extract can be used.
The mixing ratio of the added antimicrobial agent is preferably 0.01 to 3 parts by weight based on 0.01 to 3 parts by weight of lemon leaf extract.
Thereafter, the mixture is stirred to obtain a disinfectant for external use containing a Monarch Leaf Extract and a Lemon Leaf Extract.
Production Example 1
Leaves of lavender and lemon were selected and dried for 3 days at 25 ℃ by cold air drying method.
Dried laver leaves and lemon leaves were each pulverized into 50 mesh sizes.
The crushed soft white leaves were extracted by steam distillation. At this time, the pressure of the supplied steam was set to 3.0 kgf / cm 2 , and the pressure of the compressed air supplied was set to 2 atm.
The mixing ratio of the extracted untreated water and the untreated oil was 1:20, to obtain a soft white leaf extract.
The crushed lemon leaves were also extracted with supercritical fluid extraction at a temperature of 40 ° C and a pressure of 200 bar for 140 minutes.
Leaf Leaf Extract and Lemon Leaf Extract were respectively filtered by reduced pressure filtration.
The filtered cottonseed leaf extract and lemon leaf extract were each concentrated by concentration under reduced pressure.
0.08 part by weight of lemon leaf extract was mixed with 30 parts by weight of cottonseed leaf extract and 70 parts by weight of alcohol, and concentrated alcoholic liquorice extract and lemon leaf extract were mixed and then alcohol was added thereto.
The mixture was then stirred to complete the external disinfectant.
Manufacturing example 2.
The extract was prepared in the same manner as in Preparation Example 1, except that the mixture of the extracted untreated water and the untreated oil was 1:40.
Manufacturing example 3.
Was prepared in the same manner as in Preparation Example 1, and the mixture of the extracted untranslated water and the untranslated oil was used at a ratio of 1:60.
Manufacturing example 4.
The extract was prepared in the same manner as in Preparation Example 1, except that the mixture of the extracted untreated water and the untreated oil was mixed at a ratio of 1:80.
Manufacturing example 5.
The extract was prepared in the same manner as in Preparation Example 1, except that 30 parts by weight of the Leaf Leaf Extract, 0.03 part by weight of aloe vera, 0.04 part by weight of sodium hyaluronate, 0.04 parts by weight of aloe vera, And concentrated lanolin leaf extract and lemon leaf extract at a mixing ratio of 0.08 part by weight of pine and pine leaf extract were mixed, followed by addition of alcohol, aloe vera, hyaluron sodium and pine needle extract.
Comparative Example One.
Which was prepared in the same manner as in Preparation Example 3, except that 0.07 part by weight of Lemon Leaf Extract was mixed with 30 parts by weight of Leaf Leaf Extract and 70 parts by weight of Denatured Alcohol, concentrated enriched Leaf Leaf Extract and Lemon Leaf Extract, And further mixed.
Comparative Example 2.
Was prepared in the same manner as in Preparation Example 3, and lemon leaf extract was not used.
Reference example 1. Evaluation of fragrance preference of external disinfectant according to alcohol type
In order to evaluate the fragrance preference of the external disinfectant according to the present invention, the preference for the fragrance of the external disinfectant prepared using the modified alcohol and the external disinfectant prepared using the alcohol was evaluated.
The external disinfectant used in the evaluation was manufactured by using the alcohol of Preparation Example 3 and the modified alcohol of Comparative Example 1, and the evaluation was performed on 25 adults.
The 7 - point scale was used for the evaluation, and the higher the score, the higher the preference.
As a result of the evaluation, the fragrance preference of the preparation example 3 was evaluated to be higher than the fragrance preference of the comparative example 1.
On the other hand, in Comparative Example 1, there were many opinions that it was rejected by the irritating odor of acetone. On the other hand, in Production Example 3, there were many opinions that there was no irritating odor and it was convenient to use.
Modified alcohols are compounds which are toxic or odorous as a modifier in alcohol to prevent ingestion of industrial alcohols. Many compounds are used as modifiers, including methanol, benzene and benzene.
Alcohol is a colorless liquid, which has a unique direction and irritancy but no toxicity. It is also called ethanol, ethyl alcohol, grain alcohol and ethyl hydroxide.
Alcohol is produced by fermenting the starch which contains cereal (rice, barley and corn) and documents (sweet potato, potato and tapioca) with fermentable sugar by saccharification with microorganism or enzyme etc., It is mainly divided into starch raw materials and carbohydrate raw materials.
In other words, it was confirmed that the modified disinfectant manufactured by using modified alcohol was more alcoholic than the external disinfectant manufactured by using the alcohol, because the component that makes the smell bad is added to the denatured alcohol.
Reference example 2. Linseed oil and Unfinished Evaluation of preference according to composition ratio
In order to evaluate the preference according to the composition ratio of the untreated white oil and the untreated water according to the present invention, the volatility, use feeling, moisturizing effect and fragrance preference of the external disinfectant were evaluated.
The external disinfectant used in the evaluation was an external disinfectant prepared by preparing the composition of Example 1 in a proportion of 1:20 of the white oil and the white water of Example 1, A disinfecting agent, an external disinfectant prepared by preparing the composition of Example 3 in a proportion of 1:60 of the untreated white oil and the untreated water, and the external disinfectant prepared by preparing the untreated white oil and the untreated water in a ratio of 1:80, Was performed on 25 adults.
For the evaluation, the 7 point scale method was used. Volatility, moisturizing, and incense preference were set to be higher as the score increased, and stickiness was set to be higher as the score decreased.
As a result of the evaluation, the volatility was evaluated in the order of Production Example 1, Production Example 2, Production Example 3 and Production Example 4, and the volatility of Production Example 4 was evaluated to be the most excellent.
Production Example 4 was prepared by mixing the untranslated oil and the untreated water at a ratio of 1:80, and it was evaluated that there was no residual feeling because the ratio of the untreated water was higher than that of the other external disinfectants and the volatility was excellent.
The stickiness was evaluated in the order of Production Example 4, Production Example 3, Production Example 2 and Production Example 1, and it was evaluated that Production Example 1 felt the most stickiness and Production Example 4 felt the least amount of stickiness.
Production Example 1 was prepared by mixing the untranslated oil and the untranslated water at a ratio of 1:20, and it was evaluated that the tackiness was most felt because the proportion of the untranslated oil was higher than that of the other external disinfectants.
The moisturizing feeling was evaluated in the order of Production Example 4, Production Example 1, Production Example 2 and Production Example 3, and the moisturizing property of Production Example 3 was evaluated to be the most excellent.
Production Example 3 was prepared by blending white cotton oil and white cotton water at a ratio of 1:60. When the white cotton oil having a moisturizing and soothing effect and the white cotton oil having a moisturizing effect were mixed at a ratio of 1:60, It was evaluated as felt.
The fragrance preference was evaluated in the order of Production Example 4, Production Example 3, Production Example 2 and Production Example 1, and the fragrance preference of Production Example 1 was evaluated to be the highest.
Production Example 1 was prepared by mixing the untranslated oil and the untreated water at a ratio of 1:20, and it was evaluated that the fragrance preference was the highest because of the high percentage of untreated oil compared to the relatively different external disinfectants.
In other words, when the volatility, stickiness, moisturizing effect and fragrance preference are combined, it was confirmed that the preference of the external disinfectant manufactured by the composition of the whitening oil and the bleaching water at the ratio of 1:60 was the highest.
Reference Example 3. Evaluation of moisturizing and fragrance preference by adding lemon leaf extract, moisturizer and antibiotics
To evaluate the preference according to the lemon leaf extract of the present invention, the moisturizing and flavor preference of the external disinfectant was evaluated.
In order to evaluate the preference according to the additional humectant and antimicrobial agent of the present invention, the moisturizing and flavor preference of the external disinfectant was evaluated.
The external disinfectant used in the evaluation was an external disinfectant containing no lemon leaf extract of Comparative Example 2 as an active ingredient, external disinfection containing the lemon leaf extract of Preparation Example 3 as an active ingredient, and lemon leaf extract of Preparation Example 5 Moisturizers, and antimicrobial agents as active ingredients. The evaluation was conducted on 25 adults.
The 7 - point scale was used for the evaluation, and the higher the score, the higher the preference.
As a result of the evaluation, the moisturizing feeling was evaluated in the order of Comparative Example 2, Production Example 3 and Production Example 5, and the moisturizing effect of Production Example 5 was evaluated to be the most excellent.
The fragrance preference was also evaluated in the order of Comparative Example 2, Production Example 3 and Production Example 5, and the fragrance preference of Production Example 5 was the highest, and the fragrance preferences of Production Example 3 and Production Example 5 were evaluated similarly.
Lemon leaf extract has excellent moisturizing effect and it improves sensation of dryness after using external disinfectant containing alcohol, and also has effect of neutralizing alcohol fragrance through lemon scent. Therefore, it is more effective than external disinfectant manufactured without lemon leaf extract It was evaluated that the external disinfectant manufactured by using lemon leaf extract had high moisturizing and flavor preference.
In addition, the moisturizing effect of the lemon leaf extract and the added moisturizing effect of the added moisturizing agent were enhanced, and the moisturizing effect of Preparation Example 5 was evaluated to be the highest.
Claims (7)
Crushing the dried monocotyledonous leaves and lemon leaves, respectively;
Extracting the crushed soft white leaves and lemon leaves respectively;
Filtering the leek leaf extract and lemon leaf extract, respectively;
Concentrating the filtered leek leaf extract and lemon leaf extract, respectively; And
And mixing and stirring the concentrated white currant leaf extract and the lemon leaf extract with addition of alcohol, followed by mixing and stirring.
Wherein the blending ratio of the lemon leaf extract is 20 to 40 parts by weight and the alcohol is 60 to 80 parts by weight on the basis of 0.01 to 3 parts by weight of the lemon leaf extract.
The external use disinfectant according to any one of claims 1 to 3,
0.01 to 3 parts by weight of a humectant and 0.01 to 3 parts by weight of an antibacterial agent are further mixed in the step of mixing and stirring, and a method for producing the same.
The moisturizing agent may be selected from the group consisting of isopropyl myristate, propylene glycol, glycerin, silicone derivatives, aloe vera, sorbitol, glycerin fatty acid ester ) And sodium hyaluronate are used as the external disinfectant, and a method for producing the external disinfectant.
The antimicrobial agent may be at least one selected from the group consisting of Rhodiola extract, Panax ginseng extract, Seokchonpo extract, Creation extract, Root extract, Root extract, Gamma extract, Root extract, Phagocyte extract, Omiza extract, , Pine needle extract, and Gugija extract are used as the external disinfectant, and a method for producing the external disinfectant.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101868127B1 (en) | 2017-05-31 | 2018-06-18 | 강원식 | Disinfecting agent using Thuja orientalis extract and its preparation method |
| KR102228171B1 (en) * | 2020-07-30 | 2021-03-16 | (주)디마인화장품 | Sanitizer mix composition |
| KR102265471B1 (en) | 2020-11-24 | 2021-06-30 | 찬솔사회적협동조합 | Manufacturing appartus and method for disinfectant water |
| WO2022075594A1 (en) * | 2020-10-07 | 2022-04-14 | 주식회사 휴메디솔 | Hand sanitizer based on biocompatible mpc polymer and production method therefor |
| KR20220052535A (en) * | 2020-10-21 | 2022-04-28 | 박성주 | Disinfacting agent using water containing chamaecyparis obtus and maunfacturing method thereof |
| KR20220071570A (en) * | 2020-11-24 | 2022-05-31 | 동의과학대학교산학협력단 | Composition of noxious insect repellent and disinfectant, manufacturing method thereof and composition of noxious insect repellent and disinfectant manufactured by the method |
| KR20230101298A (en) * | 2021-12-29 | 2023-07-06 | 한남대학교 산학협력단 | Antibacterial composition containing Salvia miltiorrhiza extract |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20000023826A (en) | 1999-01-16 | 2000-04-25 | 데이비드 엠 모이어 | Use of a combination of surfactants, chelating agents and essential oils for effective disinfection |
| KR20010013210A (en) | 1997-05-30 | 2001-02-26 | 데이비드 엠 모이어 | Disinfecting compositions and processes for disinfecting surfaces |
-
2015
- 2015-08-18 KR KR1020150116131A patent/KR20170021573A/en not_active Application Discontinuation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20010013210A (en) | 1997-05-30 | 2001-02-26 | 데이비드 엠 모이어 | Disinfecting compositions and processes for disinfecting surfaces |
| KR20000023826A (en) | 1999-01-16 | 2000-04-25 | 데이비드 엠 모이어 | Use of a combination of surfactants, chelating agents and essential oils for effective disinfection |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101868127B1 (en) | 2017-05-31 | 2018-06-18 | 강원식 | Disinfecting agent using Thuja orientalis extract and its preparation method |
| KR102228171B1 (en) * | 2020-07-30 | 2021-03-16 | (주)디마인화장품 | Sanitizer mix composition |
| WO2022075594A1 (en) * | 2020-10-07 | 2022-04-14 | 주식회사 휴메디솔 | Hand sanitizer based on biocompatible mpc polymer and production method therefor |
| KR20220052535A (en) * | 2020-10-21 | 2022-04-28 | 박성주 | Disinfacting agent using water containing chamaecyparis obtus and maunfacturing method thereof |
| KR102265471B1 (en) | 2020-11-24 | 2021-06-30 | 찬솔사회적협동조합 | Manufacturing appartus and method for disinfectant water |
| KR20220071570A (en) * | 2020-11-24 | 2022-05-31 | 동의과학대학교산학협력단 | Composition of noxious insect repellent and disinfectant, manufacturing method thereof and composition of noxious insect repellent and disinfectant manufactured by the method |
| KR20230101298A (en) * | 2021-12-29 | 2023-07-06 | 한남대학교 산학협력단 | Antibacterial composition containing Salvia miltiorrhiza extract |
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