KR20170002543A - 당뇨병과 같은 질환의 치료를 위한 피롤리딘 gpr40 조정제 - Google Patents
당뇨병과 같은 질환의 치료를 위한 피롤리딘 gpr40 조정제 Download PDFInfo
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- KR20170002543A KR20170002543A KR1020167033864A KR20167033864A KR20170002543A KR 20170002543 A KR20170002543 A KR 20170002543A KR 1020167033864 A KR1020167033864 A KR 1020167033864A KR 20167033864 A KR20167033864 A KR 20167033864A KR 20170002543 A KR20170002543 A KR 20170002543A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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| PCT/US2015/029422 WO2015171733A1 (en) | 2014-05-07 | 2015-05-06 | Pyrrolidine gpr40 modulators for the treatment of diseases such as diabetes |
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| EP (1) | EP3140297B1 (https=) |
| JP (1) | JP6488320B2 (https=) |
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| SG (1) | SG11201609167RA (https=) |
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| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| TWI707849B (zh) | 2018-02-13 | 2020-10-21 | 美商基利科學股份有限公司 | Pd‐1/pd‐l1抑制劑 |
| KR102591947B1 (ko) | 2018-04-19 | 2023-10-25 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| EP3820572B1 (en) | 2018-07-13 | 2023-08-16 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| US11236085B2 (en) | 2018-10-24 | 2022-02-01 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
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| US5614492A (en) | 1986-05-05 | 1997-03-25 | The General Hospital Corporation | Insulinotropic hormone GLP-1 (7-36) and uses thereof |
| US6995183B2 (en) | 2003-08-01 | 2006-02-07 | Bristol Myers Squibb Company | Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods |
| KR20120104534A (ko) * | 2009-10-06 | 2012-09-21 | 브리스톨-마이어스 스큅 컴퍼니 | 피롤리딘 ｇｐｒ40 조절제 |
| JP5864177B2 (ja) | 2011-09-15 | 2016-02-17 | 船井電機株式会社 | プロジェクタおよびプロジェクタシステム |
| CA2891535A1 (en) * | 2012-11-16 | 2014-05-22 | Bristol-Myers Squibb Company | Dihydropyrazole gpr40 modulators |
| BR112015010649A2 (pt) * | 2012-11-16 | 2017-07-11 | Bristol Myers Squibb Co | moduladores de gpr40 à base de pirrolidina |
| WO2014078610A1 (en) * | 2012-11-16 | 2014-05-22 | Bristol-Myers Squibb Company | Dihydropyrazole gpr40 modulators |
| JP6322204B2 (ja) * | 2012-11-16 | 2018-05-09 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ジヒドロピラゾールのｇｐｒ４０モジュレーター |
| DK3140296T3 (en) * | 2014-05-07 | 2018-07-23 | Bristol Myers Squibb Co | PYRROLIDIN GPR40 MODULATORS FOR TREATMENT OF DISEASES SUCH AS DIABETES |
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Also Published As
| Publication number | Publication date |
|---|---|
| CN106458987B (zh) | 2019-09-24 |
| CA2948175A1 (en) | 2015-11-12 |
| EA201692216A1 (ru) | 2017-04-28 |
| ES2671402T3 (es) | 2018-06-06 |
| AU2015256038B2 (en) | 2019-07-11 |
| EP3140297B1 (en) | 2018-04-11 |
| EA032290B1 (ru) | 2019-05-31 |
| IL248670A0 (en) | 2017-01-31 |
| US20170217930A1 (en) | 2017-08-03 |
| JP2017514865A (ja) | 2017-06-08 |
| SG11201609167RA (en) | 2016-12-29 |
| AU2015256038A1 (en) | 2016-12-22 |
| EP3140297A1 (en) | 2017-03-15 |
| BR112016025188A2 (pt) | 2017-08-15 |
| JP6488320B2 (ja) | 2019-03-20 |
| MX2016014118A (es) | 2017-02-09 |
| IL248670B (en) | 2019-09-26 |
| WO2015171733A1 (en) | 2015-11-12 |
| US10017497B2 (en) | 2018-07-10 |
| CN106458987A (zh) | 2017-02-22 |
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Patent event date: 20161202 Patent event code: PA01051R01D Comment text: International Patent Application |
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| PC1203 | Withdrawal of no request for examination |