KR20170002137A - Cosmetic composition containing horse fat ceramide - Google Patents
Cosmetic composition containing horse fat ceramide Download PDFInfo
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- KR20170002137A KR20170002137A KR1020150092169A KR20150092169A KR20170002137A KR 20170002137 A KR20170002137 A KR 20170002137A KR 1020150092169 A KR1020150092169 A KR 1020150092169A KR 20150092169 A KR20150092169 A KR 20150092169A KR 20170002137 A KR20170002137 A KR 20170002137A
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The present invention relates to a cosmetic composition containing a talc ceramide. More specifically, the present invention relates to a cosmetic composition containing a talc ceramide, which comprises 15 to 20% by weight of trehalose, 1 to 5% by weight of phytosphingolactone, 3 to 6% by weight of ceramide, The present invention relates to a cosmetic composition containing an anti-inflammatory agent, an anti-inflammatory agent, and an anti-inflammatory effect.
Description
The present invention relates to a cosmetic composition containing a talc ceramide. More specifically, the present invention relates to a cosmetic composition containing a talc ceramide, which comprises 15 to 20% by weight of trehalose, 1 to 5% by weight of phytosphingolactone, 3 to 6% by weight of ceramide, The present invention relates to a cosmetic composition containing an anti-inflammatory agent, an anti-inflammatory agent, and an anti-inflammatory effect.
Cosmetics that can provide various functions such as whitening, skin wrinkle improvement, skin moisturizing, skin regeneration, and skin irritation removal are getting more popular in cosmetics that provide conventional aesthetic functions. Accordingly, cosmetic compositions having an anti-inflammatory effect by inhibiting skin aging by promoting collagen production or inhibiting the production of inflammatory factors such as atopy or acne have been widely developed, as in the following patent documents.
<Patent Literature>
U.S. Patent No. 4,603,146 (Registered on Feb. 29, 1986) "Methods for retarding the effects of aging of the skin"
Japanese Patent No. JP10-36283 (registered on Jun. 08, 2007) "Fibroblast Growth Promoting Agent"
Korean Patent Publication No. 2003-0015654 (published on Mar. 25, 2003) "composition for external application for skin containing raspberry leaf or fruit extract"
However, the use of retinoic acid is unstable, and when applied to the skin, there is a limitation in usage due to safety problems such as irritation and redness, and chlorella extract and raspberry extract have little effect, thereby substantially promoting collagen synthesis of the skin or inhibiting the production of inflammatory factors There is a problem that an effect of improving skin function can not be expected.
SUMMARY OF THE INVENTION The present invention has been made to solve the above problems,
It is an object of the present invention to provide a cosmetic composition containing a maleic ceramide containing Mauze and Phytosphingosine and having improved skin moisturizing, wrinkle reduction and anti-inflammatory effects.
In order to achieve the above object, the present invention is implemented by the following embodiments.
According to one embodiment of the present invention, the cosmetic composition according to the present invention is characterized by including maize and phytosphingosine.
According to another embodiment of the present invention, the cosmetic composition according to the present invention further comprises ceramide 3 and glycerin.
According to another embodiment of the present invention, the cosmetic composition according to the present invention further comprises cholesterol and a fatty acid.
According to another embodiment of the present invention, the cosmetic composition according to the present invention comprises 15 to 20% by weight of marjor, 1 to 5% by weight of phytosphingolipid, 3 to 6% by weight of ceramide, and 70 to 80% It is characterized by containing talc ceramide.
According to still another embodiment of the present invention, the cosmetic composition according to the present invention is characterized in that the talc ceramide comprises 1 to 10% by weight based on the total weight of the cosmetic composition.
According to another embodiment of the present invention, the cosmetic composition according to the present invention comprises 60 to 80 parts by weight of dermophilic BGC, 8 to 12 parts by weight of horse oil, 3 to 7 parts by weight of emulsion oil, 3 to 7 parts by weight of squalane, And 5 to 10 parts by weight of diethylene glycol monoethyl ether, wherein the talc ceramide comprises 15 to 20% by weight of trehalose, 1 to 5% by weight of phytosphingolactone, 3 to 6% by weight of ceramide, And 70 to 80% by weight of glycerin.
According to another embodiment of the present invention, the cosmetic composition according to the present invention comprises 1 to 3 parts by weight of stearic acid, 1 to 2 parts by weight of Tecocoare 450, 1 to 3 parts by weight of Alaton 2121, 2 to 3 parts by weight of cetostearyl alcohol 0.5 to 1.5 parts by weight of shea butter, 2 to 6 parts by weight of squalane, 3 to 8 parts by weight of cetyl ethylhexanoate, 0.5 to 1.5 parts by weight of horse oil, 1 to 3 parts by weight of 1,2-hexanediol, 1 to 3 parts by weight of triethanolamine, 0.5 to 1 part by weight of carbonpol 940 (1%), 8 to 15 parts by weight of hyaluronic acid (1%), 25 to 35% by weight of nonionic water, And 6 to 10 parts by weight of ceramides, wherein the talc ceramide comprises 15 to 20% by weight of trehalose, 1 to 5% by weight of phytosphingolactone, 3 to 6% by weight of ceramide, and 70 to 80% by weight of glycerin .
According to the present invention, the following effects can be obtained by this embodiment.
The present invention has the effect of improved skin moisturizing, wrinkle improvement, anti-inflammation.
Fig. 1 is a graph showing the evaluation of TNF-a production inhibitory effect according to sample 1. Fig.
Fig. 2 is a graph showing evaluation of IL-6 production inhibitory effect according to sample 2. Fig.
3 is a graph showing the evaluation of collagen production efficiency according to sample 1. Fig.
4 is a graph showing the evaluation of collagen production efficacy according to sample 1. Fig.
FIG. 5 is a graph showing changes in skin moisture (AU) according to the use of a product at each time point according to samples 3 and 5.
FIG. 6 is a graph showing changes in skin moisture content (AU) according to use of different time-of-use products in
BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, a cosmetic composition containing a maey ceramide according to the present invention will be described in detail with reference to the accompanying drawings. Unless defined otherwise, all terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs and, if conflict with the meaning of the terms used herein, It follows the definition used in the specification. Further, the detailed description of known functions and configurations that may unnecessarily obscure the subject matter of the present invention will be omitted. Throughout the specification, when an element is referred to as "including " an element, it is understood that the element may include other elements as well, without departing from the other elements unless specifically stated otherwise.
The cosmetic composition according to one embodiment of the present invention contains a talc ceramide including Mauze and Phytosphingosine. Horse fat is the horse fat and has the closest composition to sebum. It has high affinity with human skin and contains about 60% or more of unsaturated fatty acid because it has similar composition ratio, oil content and water balance. So that the unsaturated fatty acid can be supplied to the skin. Unlike other animal fats, the marrow contains about 40% of saturated fatty acids such as myristic acid (3.7%), palmitic acid (26.9%) and stearic acid (9.5% It contains 60% of unsaturated fatty acids such as palmitoleic acid (7.3%), oleic acid (34.8%), linoleic acid (14.2%) and linolenic acid (0.9% have. The phytosphingosine has antimicrobial and anti-inflammatory effects and binds with fatty acids to form ceramide. The ceramide has a form in which a fatty acid is bound to phytosphingosine. In the present invention, a fatty acid contained in the horse oil binds to phytosphingosine to form a ceramide (hereinafter, referred to as a "mAh ceramide"). The composition of the fatty acids contained in the hemoglobin is similar to that of the fatty acids contained in the skin. Since the fatty acids contained in the hemoglobin are varied, ceramides having various physical properties can be obtained using fatty acids having excellent skin-affinity.
The cosmetic composition according to another embodiment of the present invention is a cosmetic composition containing a talc ceramide comprising 15 to 20 wt% of trehalose, 1 to 5 wt% of phytosphingosanic acid, 3 to 6 wt% of ceramide 3 and 70 to 80 wt% of glycerin . The above-mentioned talc ceramide may be contained in an amount of 1 to 10% by weight based on the total weight of the cosmetic composition. The cosmetic composition may further comprise cholesterol and a fatty acid.
Another cosmetic composition according to another embodiment of the present invention comprises 60 to 80 parts by weight of Dermofeel BCG, 8 to 12 parts by weight of horse oil, 3 to 7 parts by weight of emu oil, 3 to 7 parts by weight of squalane, 1.5 to 3 parts by weight of talc ceramide, and 5 to 10 parts by weight of diethylene glycol monoethyl ether (Transcutol), wherein the talc ceramide comprises 15 to 20% by weight of trehalose, By weight to 5% by weight, 3 to 6% by weight of ceramide 3 and 70 to 80% by weight of glycerin.
Another cosmetic composition according to another embodiment of the present invention comprises 1 to 3 parts by weight of stearic acid, 1 to 2 parts by weight of Tegocare 450, 1 to 3 parts by weight of Arlatone, 2 to 3 parts by weight of an alcohol (Cetostearyl alcohol), 0.5 to 1.5 parts by weight of sheer butter, 2 to 6 parts by weight of squalane, 3 to 8 parts by weight of cetyl ethylhexanoate (CEH) 0.5 to 1.5 parts by weight of horse oil, 1 to 3 parts by weight of 1,2-hexanediol, 1 to 3 parts by weight of glycerine, 0.5 to 1 part by weight of triethanolamine (TEA) 10 to 20 parts by weight of Carbopol 940 (1%) (Carbopol (1%)), 8 to 15 parts by weight of hyaluronic acid (1% And 6 to 10 parts by weight of a talc ceramide, wherein the talc ceramide comprises 15 to 20% by weight of trehalose, 1 to 5% by weight of phytosphingol, 3 to 6% by weight of ceramide, By weight to 80% by weight.
The cosmetic composition of the present invention may further comprise a composition selected from the group consisting of water-soluble vitamins, oiliness vitamins, high molecular weight peptides, polymeric polysaccharides and seaweed extract.
As the water-soluble vitamin, any of vitamin B1, vitamin B2, vitamin B6, pyridoxine, pyridoxine hydrochloride, vitamin B12, pantothenic acid, nicotinic acid, nicotinic acid amide, folic acid, vitamin C and vitamin H can be used, And salts thereof (thiamine hydrochloride, sodium ascorbate, etc.) or derivatives (sodium ascorbic acid-2-phosphate, magnesium ascorbic acid-2-phosphate etc.) can also be used as water-soluble vitamins . The water-soluble vitamin can be obtained by a conventional method such as a microorganism conversion method, a purification method from a culture of a microorganism, an enzymatic method, or a chemical synthesis method.
As the above-mentioned useful vitamins, any vitamins A, carotene, vitamin D2, vitamin D3, vitamin E (d1-alpha tocopherol, d-alpha tocopherol, d-alpha tocopherol) , And derivatives thereof (such as palmitic acid ascorbin, stearic acid ascorbic acid, dipalmitic acid ascorbic acid, dl-alpha tocopheryl acetate, dl-alpha tocopherol nicotinic acid vitamin E, DL-pantothenyl alcohol, D-pantothenyl alcohol, Ethyl ether, etc.) and the like are also included in the usable vitamins used in the present invention. The usable vitamin can be obtained by a conventional method such as a microorganism conversion method, a purification method from a culture of a microorganism, an enzyme or a chemical synthesis method.
The polymeric peptide may be any compound as long as it can be compounded in a cosmetic, and preferably collagen, hydrolyzed collagen, gelatin, elastin, hydrolyzed elastin, keratin and the like. The polymeric peptide can be obtained by a conventional method such as purification from a culture broth of a microorganism, an enzymatic method, or a chemical synthesis method, or purified from natural products such as ducks such as pigs and cows and silk fiber of silkworms .
The polymeric polysaccharide may be any compound as long as it can be compounded in cosmetics, and examples thereof include hydroxyethylcellulose, xanthan gum, sodium hyaluronate, chondroitin sulfate or a salt thereof (sodium salt, etc.). For example, chondroitin sulfate or a salt thereof can be usually purified from mammals or fish.
The seaweed extract may be any of those which can be compounded in cosmetics, but preferably include algae extract, red tiger extract, green algae extract and the like, and furthermore, coloring guanine, arginic acid, sodium alginate , Potassium alginate, and the like are also included in the seaweed extract used in the present invention. The seaweed extract can be obtained from seaweed by a conventional method.
The cosmetic composition of the present invention may contain other ingredients usually added to the cosmetic composition. For example, it is possible to use various additives such as a preservative, a moisturizer, an emollient, a surfactant, an organic and inorganic pigment, an organic powder, an ultraviolet absorber, an antiseptic, a bactericide, an antioxidant, a plant extract, a pH adjuster, Cold agents, antiperspirants, purified water, and the like.
Examples of the above-mentioned fat-soluble ingredients include ester-based fats, hydrocarbon-based fats, silicon-based fats, fluorine-based fats, animal fats and plant fats and the like. Examples of the ester-based oil include glyceryl tri-2-ethylhexanoate, cetyl 2-ethylhexanoate, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, octyl palmitate, isostearyl isostearate, But are not limited to, ethylbutyl, butylbutyl, ethylbutylbutyl, butylbutyl, isobutylbutyl, isobutylbutyl, isobutylisobutyl, isobutylisobutyl, isobutylisobutyl, Trimethylol propane, triisostearic acid trimethylol propane, tetra-2-ethylhexanoic acid pentaerythritol tri (2-ethylhexanoic acid) But are not limited to, tallow, caprylic estersyl, decyl laurate, hexyl laurate, decyl myristate, myristyl myristate, myristine sasyl, stearyl stearate, decyl oleate, Examples of the isocyanates include isophorone diisostearate, isophorone diisostearate, isophorone diisostearate, isophorone diisostearate, isophorone diisostearate, isophorone diisostearate, isophorone diisostearate, Ethylhexanoate, stearyl 2-ethylhexanoate, hexyl isostearate, ethylene glycol dioctanoate, ethylene glycol dioleate, propylene glycol dicaprate, di (capryl, capric acid) propylene glycol , Propylene glycol dicaprylylate, dicapric acid neopentyl glycol, dioctanoic acid neopentyl glycol, tricarboxylic acid glyceryl, triunsaturated acid glyceryl, triisopalmitic acid glyceryl, triisostearic acid glyceryl, neopentanoic acid octyl Dodecylsuccinic acid, octadecanoic acid, octadecanoic acid, octadecanoic acid, octadecanoic acid, octadecanoic acid, octadecanoic acid, Polyglycerin isostearic acid ester, triisocetyl citrate, triisoalkyl citrate, triisooctyl citrate, lauryl lactate, myristyl lactate, cetyl lactate, octyldecyl lactate, octyldecyl lactate, octyldecyl isostearate, polyglycerin oleic acid ester, But are not limited to, triethyl citrate, acetyl triethyl citrate, acetyl tributyl citrate, trioctyl citrate, diisostearyl malate, 2-ethylhexyl hydroxystearate, di-2-ethylhexyl succinate, diisobutyl adipate, Propyl stearate, propyl stearate, propyl stearate, stearyl stearate, stearyl stearate, propyl stearate, stearyl stearate, Stearyl hydroxystearate, stearyl 12-stearoyl hydroxystearate, 12-stearoyl hydroxystearic acid, Allo one hydroxy stearic acid and the like esters such as cetearyl source. Examples of the hydrocarbonaceous oil include hydrocarbons such as squalene, liquid paraffin, alpha-olefin oligomer, isoparaffin, ceresin, paraffin, floating isoparaffin, polybutene, microcrystalline wax and vaseline. Examples of the silicone-based oil include polymethyl silicone, methylphenyl silicone, methyl cyclopolysiloxane, octamethyl polysiloxane, decamethyl polysiloxane, dodecamethyl cyclosiloxane, dimethyl siloxane methyl cetyloxysiloxane copolymer, dimethyl siloxane methyl stearoxysiloxane copolymer, Alkyl-modified silicone oil, and amino-modified silicone oil. Examples of the fluorine-based oil include perfluoropolyether and the like. Examples of the animal or plant oil include avocado oil, almond oil, olive oil, sesame oil, rice bran oil, new flower oil, soybean oil, corn oil, rape oil, apricot kernel oil, palm kernel oil, palm oil, castor oil, The present invention relates to a process for producing a starch-containing starch, which is selected from the group consisting of seed oil, cottonseed oil, palm oil, palm oil, cucumber nut oil, wheat germ oil, rice germ oil, Animal or vegetable fats such as oil, can-pick wax, carnauba wax, liquid lanolin, and hardened castor oil.
Examples of the moisturizing agent include water-soluble low-molecular moisturizing agents, oil-soluble molecular moisturizing agents, water-soluble polymers, and oil-soluble polymers. Examples of the water-soluble low molecular weight moisturizing agent include serine, glutamine, sorbitol, mannitol, sodium pyrrolidone-carboxylate, glycerin, propylene glycol, 1,3-butylene glycol, ethylene glycol, polyethylene glycol B Propylene glycol (polymerization degree n = 2 or more), polyglycerin B (polymerization degree n = 2 or more), lactic acid, lactic acid salt and the like. Examples of the lipid-soluble low-molecular moisturizing agent include cholesterol, cholesterol ester and the like. Examples of the water-soluble polymer include carboxyvinyl polymer, polyaspartic acid salt, tragacanth, xanthan gum, methylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, water-soluble chitin, chitosan, dextrin, . Examples of the oil-soluble polymer include polyvinylpyrrolidone / eicosene copolymer, polyvinylpyrrolidone / hexadecene copolymer, nitrocellulose, dextrin fatty acid ester, and polymer silicone.
Examples of the molient agent include long chain acyl glutamic acid cholesteryl ester, hydroxystearic acid cholesteryl, 12-hydroxystearic acid, stearic acid, rosin acid and lanolin fatty acid cholesteryl ester.
Examples of the surfactant include nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants. Examples of the nonionic surfactant include self emulsifying monostearic acid glycerin, propylene glycol fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, POE (polyoxyethylene), sorbitan fatty acid ester, POE sorbit fatty acid ester POE glycerin fatty acid ester, POE alkyl ether, POE fatty acid ester, POE hardened castor oil, POE castor oil, POEPOP (polyoxyethylene polyoxypropylene) copolymer, POEPOP alkyl ether, polyether modified silicone, lauric acid alkanolamide , Alkylamine oxides, hydrogenated soybean phospholipids, and the like. Examples of the anionic surfactant include fatty acid soap, alpha-acylsulfonate, alkylsulfonate, alkylallylsulfonate, alkylnaphthalenesulfonate, alkylsulfate, POE alkyl ether sulfate, alkylamide sulfate, alkyl phosphate, POE alkyl ginseng salt, alkyl Amide phosphate, alkyloyl taurine salt, N-acyl amino acid salt, POE alkyl ether carboxylate, alkylsulfosuccinate, sodium alkylsulfoacetate, acylated hydrolyzed collagen peptide salt, perfluoroalkyl phosphate ester and the like . Examples of the cationic surfactant include alkyl trimethyl ammonium chloride, stearyl trimethyl ammonium chloride, stearyl trimethyl ammonium bromide, cetostearyl trimethyl ammonium chloride, distearyl dimethyl ammonium chloride, stearyl dimethyl benzyl ammonium chloride, behenyl trimethyl ammonium bromide, Benzalkonium chloride, diethylaminoethylamide stearate, dimethylaminopropylamide stearate, quaternary ammonium salts of lanolin derivatives, and the like. Examples of the amphoteric surfactant include carboxybetaine, amidebetaine, sulfobetaine, hydroxysulfobetaine, amidosulfobetaine, phosphobetaine, aminocarboxylate, imidazoline derivative, amideamine, etc. , And the like.
Examples of the organic and inorganic pigments include silicic acid, anhydrous silicic acid, magnesium silicate, talc, sericite, mica, kaolin, spinach, clay, bentonite, titanium coated mica, bismuth oxychloride, zirconium oxide, magnesium oxide, Inorganic pigments such as aluminum, calcium sulfate, barium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, iron oxide, chromium oxide, chromium oxide, chromium oxide, But are not limited to, polyamide, polyester, polypropylene, polystyrene, polyurethane, vinyl resin, urea resin, phenol resin, fluororesin, silicon resin, acrylic resin, melamine resin, epoxy resin, polycarbonate resin, Silk powder, cellulose, CI Pigment Yellow, CI Pigment Orange, and composite pigments of inorganic pigments and organic pigments thereof.
Examples of the organic powder include metal soaps such as calcium stearate; Metal salts of alkyl phosphates such as sodium zinc cetylate, zinc laurylate and calcium lauryl laurate; Acylamino acid polyvalent metal salts such as N-lauroyl-beta-alanine calcium, N-lauroyl-beta-alanine zinc and N-lauroylglycine calcium; Amidosulfonic acid multivalent metal salts such as N-lauroyl-taurine calcium and N-palmitoyl-taurine calcium; Such as N-epsilon-lauroyl-L-lysine, N-epsilon-palmitoylidene, N-alpha-paratyylnitine, N-alpha-lauroyl arginine, Acyl basic amino acids; N-acylpolypeptides such as N-lauroylglycylglycine; Alpha-amino fatty acids such as alpha-aminocaprylic acid, alpha-aminoaurauric acid, and the like; Polyethylene, polypropylene, nylon, polymethylmethacrylate, polystyrene, divinylbenzene-styrene copolymer, ethylene tetrafluoride, and the like.
Examples of the ultraviolet absorber include ultraviolet absorbers such as p-aminobenzoic acid, ethyl p-aminobenzoate, amyl paranobenzoate, octyl p-aminobenzoate, ethylene glycol salicylate, phenyl salicylate, benzyl salicylate, benzyl salicylate, butylphenyl salicylate, homomenthyl salicylate, Benzyl, 2-ethoxyethyl methoxycinnamate, octyl methoxycinnamate, mono-2-ethylhexane glyceryl dipyrromethoxycinnamate, isopropyl methoxycinnamate, diisopropyl-diisopropyl cinnamate ester mixture, Dihydroxymethoxybenzophenone sulfonic acid, dihydroxybenzophenone sulfonic acid, dihydroxybenzophenone sulfonic acid and its salt, dihydroxymethoxybenzophenone, sodium dihydroxymethoxybenzophenone disulfonate, dihydroxybenzo Phenanone, tetrahydroxybenzophenone, 4-tert-butyl-4'-methoxydibenzoylmethane, 2,4,6-trianylino-p- (carbo-2'-ethylhexyl- 1,3,5-triazine, 2- (2- And the like can be de-hydroxy-5-methylphenyl) benzotriazole.
Examples of the bactericide include antibiotics such as hinokitiol, trichloroacid, trichlorohydroxydiphenyl ether, crohexidine gluconate, phenoxyethanol, resorcin, isopropylmethylphenol, azulene, salicylic acid, No. 301, mononitro and eicoll sodium, undecylenic acid, and the like.
Examples of the antioxidant include butylhydroxyanisole, gallic acid propyl, and eicosorbic acid.
Examples of the pH adjuster include citric acid, sodium citrate, malic acid, sodium malate, fumaric acid, sodium fumarate, succinic acid, sodium succinate, sodium hydroxide, sodium monohydrogenphosphate and the like.
Examples of the alcohol include higher alcohols such as cetyl alcohol.
In addition, any of the above components may be blended within the range not impairing the object and effect of the present invention, but is preferably 0.01 to 5% by weight based on the total weight, More preferably 0.01 to 3% by weight.
The cosmetic composition of the present invention may take the form of a solution, an emulsion, a viscous mixture or the like.
The ingredients contained in the cosmetic composition of the present invention may contain, as an active ingredient, the ingredients conventionally used in cosmetic compositions in addition to the above-mentioned compounds, for example, conventional additives such as stabilizers, solubilizers, vitamins, And a carrier.
The cosmetic composition of the present invention can be prepared in any formulations conventionally produced in the art, and examples thereof include emulsions, creams, foundations, lotions, essences, and hair cosmetic compositions. Specifically, the cosmetic composition of the present invention can be used as a skin lotion, a skin softener, a moisturizing lotion, a nutritional lotion, a massage cream, a nutritional cream, a hand cream, a moisturizing cream, an essence, a pack, a soap, a lotion, a milk lotion, Cleansing foams, body cleansers, astringents, and spray formulations. When the formulation of the present invention is a paste, cream or gel, animal fiber, plant fiber, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as the carrier component . In the case where the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. Especially, in the case of a spray, a mixture of chlorofluorohydrocarbons, propane / Propane or dimethyl ether. In the case of the solution or emulsion of the present invention, a solvent, a solvent or an emulsifier is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters. When the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used. When the formulation of the present invention is an interfacial active agent-containing cleansing, the carrier component may include aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, linolenic derivatives or ethoxylated glycerol fatty acid esters.
Hereinafter, the present invention will be described in more detail with reference to Examples. However, these are only for the purpose of illustrating the present invention in more detail, but the scope of the present invention is not limited thereto.
≪ Preparation Example 1 > Preparation of Examples and Comparative Examples (Maeh Ceramide)
Examples and Comparative Examples were prepared at the composition ratios shown in Table 1 below.
PREPARATION EXAMPLE 2 Preparation of Examples and Comparative Examples (Cosmetics Containing Maey Ceramide)
Examples 1 and 2 and Comparative Examples 1 and 2 were prepared in the composition ratio shown in Table 2 below. However, the maey ceramide contains 17% by weight of trehalose, 3% by weight of phytosphingosine, 4% by weight of ceramide, and 76% by weight of glycerin.
(Sample 3)
(Sample 4)
(Sample 5)
(Sample 6)
<Experimental Example 1> Evaluation of anti-inflammatory activity (Evaluation of TNF-α and IL-6 production inhibitory activity)
1) Hacat cells at a concentration of 1 × 10 5 cells / ml were inoculated into a 24-well plate using DMEM medium and cultured for 24 hours. Subsequently, the medium was removed, and sample 1 (1 mg / ml) was treated at different concentrations with UV irradiation and cultured under the same conditions as the pre-culture. After 24 hours, the culture medium was centrifuged (12,000 rpm, 4 minutes) and the content of pro-inflammatory cytokines produced in the supernatant was measured. The results are shown in FIGS. 1 and 2. The r2 value of the standard curve for the standard was calculated by using a mouse enzyme-linked immunosorbent assay (ELISA) kit (R & D Systems Inc., Minneapolis, MN, USA) 0.99 or more.
2) Referring to FIGS. 1 and 2, it was confirmed that the production of TNF-α and IL-6 was further suppressed as the concentration of mAb ceramide increased.
EXPERIMENTAL EXAMPLE 2 Evaluation of wrinkle-improving efficacy (evaluation of procollagen production efficacy)
1) Fibroblast, one of the cell lines involved in collagen production, was cultured in Dulbecco's modified essential medium (DMEM, Welgene, Korea) containing 1% Antibiotic-Antimycotic (AA, Welgene, Korea) and 10% Fetal bovine serum ) for 37 ℃, 5% CO 2 using incubator. Fibroblast cells at a concentration of 2 × 10 5 cells / ml were inoculated on a 6-well plate and cultured for 24 hours. The medium was removed and starved for 24 hours in serum-free medium. After 24 hours, the serum-free medium is removed, washed with PBS, and irradiated at 12.5 mJ at a UV 312 nm wavelength. After that, Samples 1 and 2 were treated with phenolred free DMEM at different concentrations and further cultured for 48 hours. After 48 hours of incubation, collect the medium and cell lysate, respectively. RIPA buffer containing protease inhibitor is added to each well, and then cell lysate is collected on a cell scraper on ice. After centrifugation at 14,000 rpm for 10 minutes, the supernatant is recovered and the amount of protein is corrected using the Bradford assay. The collected media were measured for collagen amount using a Procollagen Type-I C-Peptide (PIP) EIA kit (Takara Bio Inc. MK101) and shown in FIGS. 3 and 4.
2). Referring to FIG. 3, it can be seen that the production of procollagen is further promoted as the concentration of the MAH ceramide is increased. In contrast to FIGS. 3 and 4, when compared with the sample 2 containing phytosphingosine, It was found that the sample 1 containing the high stringer produced a relatively large amount of procollagen.
<Experimental Example 3> Sensory test on skin moisturizing effect
1) Skin moisturizing effect was measured using a cosmetic having the compositions of Samples 3 to 6. The test subjects were 20 women with dry skin between 20 and 55 years old. The measurement time was before the product use, immediately after the product use, 1 hour and 3 hours after the measurement. The measurement site was 5cm, 10cm (Left and right). The evaluation methods and items were as follows. The test product was applied at four locations on the inner side of the front of the selected study subjects, and the sample was applied once by the tester (randomly applied double blind spot) The skin moisture content was measured at each time point of measurement. Skin moisture was measured using the Corneometer® CM825 (Courage + Khazaka GmbH, Germany). Statistical analysis was performed using the Repeated measures ANOVA and ANCOVA methods of the SPSS package program. The skin moisture content measurement results are shown in FIGS. 5 and 6. FIG.
2) As shown in FIG. 5, it can be seen that the cosmetic of Sample 3 is superior to the sample 5 in skin moisturizing effect. FIG. 6 shows that the cosmetic of Sample 4 is superior to
While the present invention has been described in connection with what is presently considered to be practical exemplary embodiments, it is to be understood that the invention is not limited to the disclosed embodiments, but, on the contrary, Should be interpreted as belonging to the scope.
Claims (7)
A cosmetic composition characterized by further comprising ceramide 3 and glycerin.
Wherein the composition further comprises cholesterol and a fatty acid.
And 1 to 10% by weight based on the total weight of the cosmetic composition.
The cosmetic composition according to claim 1, wherein the talc is selected from the group consisting of 15 to 20% by weight of trehalose, 1 to 5% by weight of phytosphingolactone, 3 to 6% by weight of ceramide, and 70 to 80% by weight of glycerin.
The cosmetic composition according to claim 1, wherein the talc is selected from the group consisting of 15 to 20% by weight of trehalose, 1 to 5% by weight of phytosphingolactone, 3 to 6% by weight of ceramide, and 70 to 80% by weight of glycerin.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190079291A (en) * | 2017-12-27 | 2019-07-05 | 주식회사 코스모코스 | Cosmetic composition containing pseudo-ceramide originated from botanical oil |
| KR20210145098A (en) * | 2020-01-13 | 2021-12-01 | 경북대학교 산학협력단 | Cosmetic composition comprising syringic acid, vanillic acid, and epicatechin |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20240082798A (en) | 2022-12-02 | 2024-06-11 | 김양진 | Cosmetic composition for skin improvement |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2001199872A (en) | 1999-11-10 | 2001-07-24 | Nikko Chemical Co Ltd | Additive for ceramide formulated cosmetic and cosmetic |
| KR100667182B1 (en) | 2006-08-08 | 2007-01-12 | 주식회사 코스메카코리아 | Cosmetics for improvement xeroderma containing badger oil |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190079291A (en) * | 2017-12-27 | 2019-07-05 | 주식회사 코스모코스 | Cosmetic composition containing pseudo-ceramide originated from botanical oil |
| KR20210145098A (en) * | 2020-01-13 | 2021-12-01 | 경북대학교 산학협력단 | Cosmetic composition comprising syringic acid, vanillic acid, and epicatechin |
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