KR20160104009A - 변형된 FcRn-결합 성질을 갖는 Fc-영역 변이체 - Google Patents

변형된 FcRn-결합 성질을 갖는 Fc-영역 변이체 Download PDF

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Publication number
KR20160104009A
KR20160104009A KR1020167019016A KR20167019016A KR20160104009A KR 20160104009 A KR20160104009 A KR 20160104009A KR 1020167019016 A KR1020167019016 A KR 1020167019016A KR 20167019016 A KR20167019016 A KR 20167019016A KR 20160104009 A KR20160104009 A KR 20160104009A
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polypeptide
domain
mutations
antibody
immunoglobulin
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Ceased
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KR1020167019016A
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Korean (ko)
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틸만 슐로트하우어
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에프. 호프만-라 로슈 아게
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Publication of KR20160104009A publication Critical patent/KR20160104009A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020167019016A 2014-01-15 2015-01-12 변형된 FcRn-결합 성질을 갖는 Fc-영역 변이체 Ceased KR20160104009A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP14151319 2014-01-15
EP14151319.2 2014-01-15
EP14165922 2014-04-25
EP14165922.7 2014-04-25
PCT/EP2015/050425 WO2015107025A1 (en) 2014-01-15 2015-01-12 Fc-region variants with modified fcrn-binding properties

Publications (1)

Publication Number Publication Date
KR20160104009A true KR20160104009A (ko) 2016-09-02

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Application Number Title Priority Date Filing Date
KR1020167019016A Ceased KR20160104009A (ko) 2014-01-15 2015-01-12 변형된 FcRn-결합 성질을 갖는 Fc-영역 변이체

Country Status (11)

Country Link
US (3) US20170037121A1 (enExample)
EP (1) EP3094649A1 (enExample)
JP (2) JP6873701B2 (enExample)
KR (1) KR20160104009A (enExample)
CN (2) CN113248613B (enExample)
AR (1) AR099079A1 (enExample)
BR (1) BR112016016411A2 (enExample)
CA (1) CA2931979A1 (enExample)
MX (1) MX387180B (enExample)
RU (1) RU2730592C2 (enExample)
WO (1) WO2015107025A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
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WO2022265331A1 (ko) * 2021-06-14 2022-12-22 고려대학교 산학협력단 제어된 면역 작용 기작과 증가된 혈중 반감기를 갖는 fc변이체들

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CN111315767B (zh) 2017-08-22 2025-03-18 萨纳生物有限责任公司 可溶性干扰素受体及其用途
US11945839B2 (en) * 2017-12-22 2024-04-02 Hoffmann-La Roche Inc. Depletion of light chain mispaired antibody variants by hydrophobic interaction chromatography
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CN110054700A (zh) * 2018-01-18 2019-07-26 分子克隆研究室有限公司 长效治疗性融合蛋白
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CN112955240B (zh) * 2018-10-25 2022-09-16 豪夫迈·罗氏有限公司 抗体FcRn结合的修饰
KR102605376B1 (ko) 2018-12-31 2023-11-23 삼성디스플레이 주식회사 표시 장치
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Publication number Priority date Publication date Assignee Title
WO2022265331A1 (ko) * 2021-06-14 2022-12-22 고려대학교 산학협력단 제어된 면역 작용 기작과 증가된 혈중 반감기를 갖는 fc변이체들

Also Published As

Publication number Publication date
JP2021113214A (ja) 2021-08-05
US20170037121A1 (en) 2017-02-09
US20190016792A1 (en) 2019-01-17
AR099079A1 (es) 2016-06-29
MX387180B (es) 2025-03-18
RU2730592C2 (ru) 2020-08-24
JP7686437B2 (ja) 2025-06-02
HK1223951A1 (zh) 2017-08-11
BR112016016411A2 (pt) 2017-10-03
RU2016133345A (ru) 2018-02-20
WO2015107025A1 (en) 2015-07-23
US20240218060A1 (en) 2024-07-04
MX2016008540A (es) 2016-09-26
CN105873948B (zh) 2021-04-13
CN113248613A (zh) 2021-08-13
EP3094649A1 (en) 2016-11-23
CN105873948A (zh) 2016-08-17
RU2016133345A3 (enExample) 2018-10-31
CA2931979A1 (en) 2015-07-23
JP6873701B2 (ja) 2021-05-19
JP2017505768A (ja) 2017-02-23
CN113248613B (zh) 2024-08-23

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