KR20160102669A - Composition for preventing or treating of Henoch-Schonlein Purpura - Google Patents

Abstract

The present invention relates to a composition for preventing or treating allergic purpura. More specifically, injection of Gamiyookmijihwangtang to a patient suffering from allergic purpura accompanying symptoms of yin deficiency has shown effectiveness in reduction of symptoms such as purpura, stomachache, arthritis, and edema without recurrence, after a certain lapse of time. Thus, the composition of the present invention can be useful for treating allergic purpura.

Description

TECHNICAL FIELD The present invention relates to a composition for preventing or treating allergic purpura,

The present invention relates to a composition for the prevention or treatment of allergic purpura, particularly allergic purpura diagnosed as parasitic.

Allergic purpura is a type of vasculitis called Henoch-Shonlein purpura, anaphylactic purpura, which is characterized by purpura manifesting on the skin without platelet depression, gastrointestinal symptoms, joint symptoms or kidney symptoms to be.

 The etiology or pathogenesis of the disease is unclear, but it is likely to be related to immune complexes deposited in the vessel wall. Also, considering that the above infection is preceded by infection, it is also related to bacterial or viral infection, and its association with antigens such as drugs, insect bites, and foods is also suggested.

Allergic purpura is reported to occur in about 14 to 18 people per 100,000 people, and it is known that allergic purpura is most common, with about 70.3 per 100,000 people aged 4 to 6 years.

Clinical symptoms are jaundice, arthralgia, abdominal pain and glomerulonephritis, which are recurrent in the lower extremities.

In allergic purpura, the promoter of the skin appears in all patients. It is rarely seen in the face, palms, soles, and so on, as it first appears on the body part of the hips and in the lower part of the lower limbs. In the early stage, the papule appears as a papule papule, gradually turns brown and faded and disappears, but a new papule group emerges continuously over a period of several weeks.

Gastrointestinal symptoms are abdominal pain, nausea, vomiting, stool, and hematemesis. Gastrointestinal symptoms preceded the disease rather than misdiagnosis as another disease. Abdominal pain usually appears in the middle of the umbilicus, and gastrointestinal endoscopy can be seen mainly in gastric mucosa and petechiae. In rare cases, complications such as intussusception, intestinal obstruction, intestinal perforation, and acute pancreatitis are accompanied, and surgical treatment may be necessary.

The joint symptoms are not the joint itself, but the surrounding tissues are damaged. The knee joint, ankle joint and elbow joint are the most common. Rarely, multiple joints are involved at the same time. The severity of the symptoms varies from simple edema to severe pain and limitation of movement, and most of the pain disappears without severe aftereffects because of damage to the periarticular tissue.

Renal symptoms are the most important symptoms affecting the prognosis and the recurrence of allergic purpura, with gross or microscopic hematuria and proteinuria. It is reported that about 20% to 50% of allergic patients have nephrotic syndrome, though there are some differences according to the study. Symptoms usually appear within the first 3 months of symptom onset. Unlike IgA nephritis with similar symptoms, the progression is good and usually recovered asymptomatically. However, 5 to 10% may progress to subacute or chronic progression, severe renal failure may occur, and patients with renal symptoms should be cautious because recurrence of allergic purpura is common. In rare cases, nephritis is also reported after 3 months of puberty and 5 years after puberty, and continuous observation is required. Other rare cases include central nervous system symptoms such as consciousness impairment, convulsions, and paralysis.

There is no special treatment for allergic purpura, mainly symptomatic therapy is performed. Sometimes they use systemic steroids, which may help with joint symptoms or abdominal pain, but they have no effect on preventing or improving kidney symptoms.

In general, steroid therapy is the first choice for allergic purpura, but steroid therapy can cause many side effects. In addition, steroid treatments may improve the symptoms of purpura or prevent kidney symptoms, so it seems to be meaningful in oriental medicine treatment. However, there has been only literature review and case report of allergic purpura. Up to now, only 1 or 2 reports have been reported, and clinically significant prescriptions have been lacking.

1. Pediatr Nephrol. 7: 69-71. 1993.

Accordingly, it is an object of the present invention to provide a pharmaceutical composition for preventing or treating allergic purpura.

Another object of the present invention is to provide a health food for preventing or ameliorating allergic purpura.

In order to attain the above object, the present invention relates to a method for the production of a medicinal herb containing at least one selected from the group consisting of Angelica keiskei, Angelica keiskei, Glycine, Gilt-europaea, Malt, The present invention provides a pharmaceutical composition for preventing or treating allergic purpura.

The present invention also provides a pharmaceutical composition for the prevention or treatment of allergic purpura characterized in that the present invention includes dry ginseng, liquorice, corn oil, white bream, rhododendron, phytase, ginseng, hwanggi, glue, ginseng, allium, malt, ginseng and killing do.

In order to achieve the above-mentioned further object, the present invention provides a method of manufacturing a honeycomb structure, which is selected from the group consisting of Angelica gigas, Hwanggi, glue, goldsmith, allium, malt, ginseng, The present invention provides a health food for preventing or ameliorating allergic purpura characterized by further comprising at least one compound of the present invention.

The present invention also provides a health food for the prevention or improvement of allergic purpura characterized by comprising ginseng root, liquorice, corn oil, white bream, rhododendron, phytose, Angelica gigas, glutinous rice, gilt eum, allium, malt, ginseng and killing do.

In case of administering to a patient suffering from allergic purpura diagnosed as licorice, the gummi yemmi jiulhangtang which is added with herb medicine according to the present invention, symptoms such as vagina, abdominal pain, arthritis and edema And thus can be usefully used for the prevention or treatment of patients with allergic purpura.

FIG. 1 is an image showing the progress of treatment in a 5-year-old patient to which Gamitoxifene is administered according to the present invention,
FIG. 2 is an image showing the progress of treatment of a 6-year-old patient to which Gamitlandia japonica is administered according to the present invention,
FIG. 3 is an image showing the progress of treatment of an 11-year-old patient who has been administered with a gummy herring juganghangtang according to the present invention,
FIG. 4 is an image showing the progress of treatment of a 5-year-old patient who has been administered with the Gamitland yummy herbarium according to the present invention,
FIG. 5 is an image showing the progress of treatment of a 6-year-old patient to which Gamitoxifene is administered according to the present invention,
FIG. 6 is a graph showing the treatment progress of 20 cases in which Miwanghang-tang was applied to the Kami land according to the present invention.

Hereinafter, the composition for preventing or treating allergic purpura of the present invention will be described in more detail.

The inventors of the present invention have found that a composition having an efficacy for treating allergic purpura by additionally adding herbal medicines to a Korean herb medicine (六味 地 黄 汤) effective for improving the tolerance to allergic purpura showing common herbicidal characteristics And completed the present invention.

Herbal medicines include allergic purpura (purpura), blood (血 证), grape (vine) and belong to the category. The cause of the disease is a large feudal lord (阴虛 火 旺), which is a high fever caused by the loss of the provenance, 气虛 不 坐, , Which is the most common symptom. When the external stimuli are accepted, they are detoxified and the heat poison is transmitted to the blood, so that the blood vessels and the blood vessels are broken up to form purpura. do. In the case of encephalopathy (气虛 不 胎) is born or unhealthy (脾 虛) due to lack of gihyeolhage (气血 生化 不足) and can not control the blood (脉 外) (Purple). In addition, pediatric patients can easily become depressed because of lack of pharmacologic abstinence, and they are often referred to as "depressed mood swallowing, sleep deprivation, depressed mood swallowing, Skin "). In addition, when the illness has become ill for a long time, the blood becomes inflamed through the fire.

All of the above patients were aged between 5 and 14 years of age and could not be easily excluded because of their age and age. When the usual symptoms and pulse were taken into consideration, Water shortage) was selected as the raw material.

Jokmi Jiwanghangtang is composed of 熟地 黄, 山水, 山药, 白 茯 笭, 瀉 泻 and 牧 皮 皮. Sukjihwang has been used as a main medicine because it has the efficacy of self-pruning (滋 腎 塡 精) with steamed root of Chinese medicine and dried Chinese medicine. It is used for nursing liver and kidney, Which is a perennial vine plant belonging to the myrrh which strengthens the vigor and strengthens the vigor and strengthens the vigor (shin yin), which is the fruit of the stratum corneum, Respectively. By using these three drugs together, you will achieve an efficacy that will help you with the triumph of overseating, noise, and lunacy. In addition, when the dried bokbyeol of Poria cocas Wolf. Which is a parasitic mushroom from dead pine trees is mixed with considering the interactions between the drugs, it is possible to supplement the rainfalls of the wild rice paddies, A perennial plant, which grows in a pond, acts to soothe the heat of the kidneys and prevents the slim and sticky nature of the seeds. Paeonia suffruticosa Andrews peony peony (peony) is a medicinal herb that acts to calm the heat of the liver as well as to limit the temperament of acidity, so the drugs that lead to the drug,药) was used as. However, since the patients exhibited symptoms of insomnia (阴虛 火 动), they were used instead of 지 황 하는 (地 黄 黄), which removes the heat of the blood while lengthening the sound rather than improving the sound.

It is based on this kind of Ji-mi Jiwanghang-tang, which has the effect of cooling down the fever and cooling down the fever caused by the heat while supplementing the water and reducing the heat, and the heat of the lungs (mainly used as root medicine) (Phllostachys nigra Munro var. Henosis Stapf), which has the effect of lowering and removing sputum, or kelp (phloostachys bambusoides Sieb. Et Zucc.) Which is the fruit of Forsythia viridissima Lindley or Forsythia suspensa Vahl, which is a flower bud of Lonicera japonica Thunberg and its varieties, ), Which is the root of perennial oriental herbaceous angelica belonging to the persimmon which has the efficacy to add blood and the blood of the goat, and the animal's leather, tendons, intestines and bones. A solidifying the body (固 形 化) a substance of glue (阿膠) was more. In addition, it is a perennial herbaceous plant belonging to the bean curd promoting Yanggwa, which is added to help the living blood. It helps digest the food, harmonizes the middle period, strengthens the rain and opens the stomach. The sprouts of Hordeum vulgare Linne (barley) were dried out and added with slightly fermented malted germ to make the live blood smooth.

Accordingly, the present invention relates to a method for the treatment of Alzheimer's disease, such as Rehmannia glutinosa, Dioscorea batatas DECNE, Macrocarpium officinale NAKAI, Poria cocos. (Schw.) Wolf, Moutan Root Bark and Alismatis Rhizoma In order to investigate the effects of angiica sinensis (OLIV) DIELS, Astragalus membranaceus BUNGE, glue, Lonicera japonica Thunb, Forthesia suspensa, malt, Scrophularia burgeriana MIQ ), And Bambusae. The present invention also provides a pharmaceutical composition for preventing or treating allergic purpura.

In addition, the present invention provides a pharmaceutical composition for the prevention or treatment of allergic purpura characterized by comprising ginseng root, liquorice, corn oil, white bream, rhododendron, phytase, Angelica gigas, glue, glue, gilt eum, allium, malt, ginseng and killing do.

Wherein the pharmaceutical composition comprises 5 to 15 parts by weight of dried persimmon; 5 to 15 parts by weight of an acid; 5 to 15 parts by weight of corn oil; 3 to 10 parts by weight; 3 to 10 parts by weight; 3 to 10 parts by weight of a taxane; 3 to 10 parts by weight of Angelica keiskei; 5 to 15 parts by weight of sulfur; 3 to 10 parts by weight of glue; 3 to 10 parts by weight of gold silver; 3 to 10 parts by weight of alum; 3 to 10 parts by weight of malt; 1 to 8 parts by weight of ginseng; And 1 to 8 parts by weight of killing.

When the concentration is out of the above range, the efficacy of each medicament may be lowered or the problem may be exerted more than necessary.

In addition, the pharmaceutical composition of the present invention may be formulated into any one form selected from the group consisting of a tablet, a troche, a capsule, a tablet, a granule, a ring, a powder, a suspension and a solvent according to a conventional method, can do.

The pharmaceutical compositions may further comprise suitable carriers, excipients or diluents conventionally used in the manufacture of pharmaceutical compositions.

Examples of the carrier, excipient or diluent which can be used in the present invention include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, Methylcellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate or mineral oil.

In the case of formulation, a diluent or excipient such as a filler, an extender, a binder, a wetting agent, a disintegrant, or a surfactant is usually used. Solid formulations for oral administration include tablets, pills, powders, granules, capsules and the like, which may contain at least one excipient such as starch, calcium carbonate, sucrose sucrose), lactose, gelatin, and the like.

In addition to simple excipients, lubricants such as magnesium stearate and talc are also used. Examples of the liquid preparation for oral use include suspensions, solutions, emulsions, and syrups. In addition to water and liquid paraffin, simple diluents commonly used, various excipients such as wetting agents, sweeteners, fragrances, preservatives and the like may be included .

Further, the dosage of the pharmaceutical composition according to the present invention may be increased or decreased depending on the route of administration, degree of disease, sex, weight, age, and the like. Thus, the dosage amounts are not intended to limit the scope of the invention in any manner.

In addition, the present invention further comprises at least one selected from the group consisting of Angelica keiskei, Angelica keiskei, Gypsum, Gilt-europaea, Maltose, To provide a health food for preventing or improving allergic purpura.

The present invention also provides a health food for preventing or ameliorating allergy purpura characterized by comprising ginseng powder, ginseng powder, corn oil, bacon, mulberry, phytase, Angelica keiskei, glutinous rice, ginseng, gilt eum, allium, malt, ginseng and killing.

The health food may be provided in the form of powder, granules, tablets, capsules, syrups or beverages. The health food may be used in combination with food or food additives other than the components of the present invention, Can be used. The amount of the active ingredient to be mixed can be suitably determined according to its use purpose, for example, prevention, health or therapeutic treatment.

The effective dose of the constituents contained in the above-mentioned health food may be used in accordance with the effective dose of the pharmaceutical composition, but may be less than the above range for the purpose of health and hygiene or for long-term intake for health control purposes , It is clear that the active ingredient can be used in an amount exceeding the above range since there is no problem in terms of safety.

There is no particular limitation on the type of the health food, and examples thereof include meat, sausage, bread, chocolate, candy, snack, confectionery, pizza, ramen, other noodles, gums, dairy products including ice cream, Drinks, alcoholic beverages and vitamin complexes.

Hereinafter, the present invention will be described in more detail with reference to the following examples. However, the scope of the present invention is not limited to the following examples.

< Reference example  1> Pain diagnosis

Patients' pain was measured using a visual analogue scale (Visuelle Analogskala, VAS). The VAS records the absence of pain at one end of a 10 cm long line and records the most severe pain imaginable at the end of the other. Patients were asked to fill in the pain they felt at the time.

< Example  1> Gamyoungmyumi  (味 味 地 黄 湯)

Based on 50cc of water for children, 320ml of water contains 5.625g of dried ginger, 5.625g of dried ginger, 5.625g of dried ginger oil, 3.75g of white ginger, 3.75g of ginger, 3.75g of Tadasu, 3.75g of ginger, 5.625g of ginger, 3.75 g of ginger silver, 3.75 g of maltose, 3.75 g of malt, 2.625 g of ginseng and 2.625 g of kelp were added and the mixture was pre-heated at 120 ° C. for 150 minutes to prepare a gummy egg whitener.

< Example  2> Treatment Cases

1. Case 1

1) Sex and age: Male 5 years

2) Main symptoms: Vagina, knee edema and pain, left wrist edema, abdominal pain and facial edema.

3) Current history: Between 1 and 2 weeks before the onset of the disease, bronchitis and enteritis were treated at a private clinic and symptoms of flu were also seen. On the day of onset, there were no symptoms of abdominal pain, swelling and pain in the lower leg. 2 days after onset.

4) Other symptoms:

(1) Meals: Good.

(2) Digestion: Good.

(3) Credit: Good.

(4) Urine: Good.

(5) Sleep: Good.

(6) Others: Dohan (盜汗) often appeal.

5) Treatment content:

(1) Treatment of herbal medicine: Six packs of Gamitra yammi jiulhangang prepared in Example 1 were transferred to 30 cc / pack at 50 cc / pack.

6) Treatment progress:

Treatment progress days Purple Abdominal pain Arthritis & edema pulse 01 +++ VAS 3 VAS 5 (+) Bush cutting 18th ++ - - Sheath 24th + VAS 1 - Pulse is fine. 35 days - - - Pulse is fast (弦) 88 days - - - Pulse is slow

Referring to FIG. 1 and Table 1, on the first day, the patient was accompanied by bilateral lower limbs and knee edema and pain (VAS 5). He often referred to 盜汗 (盜汗), and at the time of the initial pulse, the child was considered a child, 阴虛 火动 (陰虛 火动) was diagnosed.

 Temporary abdominal pain (VAS 3) and swelling of the face and swelling of the face were noted before the take-out, but soon disappeared. After that, the symptoms gradually improved and all symptoms disappeared after several days of treatment. On the 88th, there was no inconvenience in daily life without recurrence of purpura, and the pulse was stable and stable.

2. Case 2

1) Sex and age: Female 6 years

2) Main symptoms: Vigor, thigh pain, abdominal pain and vomiting.

3) Current history: After being treated with a cold, it was diagnosed and treated with erythema, but it did not improve. After that, he was diagnosed with allergic purpura.

4) Other symptoms:

(1) Meals: Good.

(2) Digestion: Good.

(3) Stool: Dry stool.

(4) Urine: Good.

(5) Sleep: often 깸.

(6) History: Atopy, rhinitis, stomatitis and pneumonia

5) Treatment content:

(1) Treatment of herbal medicine: Seven coats of Gamitoxifene prepared in Example 1 were transferred to 45 cc / pack in 50 cc / pack, and were taken 3 times / day, 1 pack / cycle until the end of treatment at intervals of 15 days.

6) Treatment progress:

Treatment progress days Purple Abdominal pain Arthritis & edema pulse 01 ++ VAS 3 VAS 4 (-) Shesak powerful 14 days ++ - - Sheath 49 days + - - Pulse is fine. 75 days - - - Pulse is slow

Referring to FIG. 2 and Table 2, on the first day, the patient was accompanied with bilateral lower limbs and thigh pain (VAS 4). I was awakened by not being able to take a good night's sleep. I had a history of seeing dry stools, atopy, rhinitis, and pneumonia. Considering the fact that I had a strong pulse at the time of my first visit, Respectively.

 Abdominal pain (VAS 3) and vomiting symptoms appeared before the take-out, but the symptom improved as the drug application started. On the 49th day, the skin remained mild and the other symptoms disappeared. During the treatment, the patient had a weak recurrence, but no other symptoms. On the 75th day, all the symptoms of allergic purpura had disappeared.

3. Case 3

1) Sex and age: Female 11 years

2) Main symptoms: nausea, abdominal pain, nausea, calf and ankle pain.

3) Current history: 3 ~ 4 days before the onset of the disease was treated in a private hospital in the middle of the calf, and was diagnosed with allergic purpura in a private hospital. There was no abnormality in the blood test and he was admitted to hospital for 3 days but did not improve. One day after discharge, she suddenly complained of abdominal pain and nausea. She was admitted to the Emergency Room of Seoul National University Bundang Hospital. After 6 days of hospitalization, her symptoms disappeared and abdominal pain and nausea symptoms improved. However, after discharge from hospital, her symptoms recurred and she received herbal medicine.

4) Other symptoms:

(1) Meals: small amounts.

(2) Digestion: Indigestion, abdominal pain.

(3) Credit: Good.

(4) Urine: Good.

(5) Sleep: Good.

(6) Others: Nausea, burning, nosebleeds, height growth.

(7) History: Atopy, rhinitis

5) Treatment content:

(1) Herbal medicine treatment: 10 tablets of Kami-yomi-yuanghang-tang prepared in Example 1 were dispensed in a pack of 45 cc at a dose of 50 cc / pack for 3 times / day until the end of treatment at intervals of 15 days.

6) Treatment progress:

Treatment progress days Purple Abdominal pain Arthritis & edema pulse 01 +++ VAS 4 VAS 4 (-) Bush cutting 14 days + - - Sheath 28th - VAS 1 VAS 1 (-) Pulse is over (澁) 64 days - VAS 1 - Pulse is fast (弦) 92 days - - - Pulse is slow

Referring to FIG. 3 and Table 3, on the first day, the patient was accompanied by bilateral lower limbs, abdominal pain, and calf and ankle pain (VAS 4). He often complained of frequent nausea and complaints, frequent nosebleeds, a history of atopy, and slower growth than his peers. In addition, it was diagnosed as purpura due to musculoskeletal disorder (阴虛 火 动) in consideration of the fact that the pulmonary artery was pulsed at the initial stage.

 The abdominal pain that had remained as it began to take the medicine was gradually improved, and it disappeared on the 14th day, but there was a slight left of the calm. On the 28th day, abdominal pain temporarily recurred (VAS 1), but it improved soon. On the 64th day, the bladder was completely removed. The bladder was maintained in a state where the bladder and other symptoms were completely disappeared until day 92, and the pulse was stabilized with the pulse relaxed.

4. Case 4

1) Sex and age: Male 5 years

2) Main symptoms: Vagina, knee pain and edema.

3) Current history: 5 to 6 days before the onset of illness. He was diagnosed with allergic purpura on the day of treatment, but he was treated with herbal medicine three days after the onset of severe knee pain and edema in the morning.

4) Other symptoms:

(1) Meals: Good.

(2) Digestion: Good.

(3) Stool: Dry stool.

(4) Urine: Good.

(5) Sleep: Good.

(6) Others: Dohan (盜汗), Eji (盜 遲)

(7) History: Infants' fever (4 times)

5) Treatment content:

(1) Treatment of herbal medicine: Seven coats of Gamitoxifene prepared in Example 1 were transferred to 45 cc / pack in 50 cc / pack, and were taken 3 times / day, 1 pack / cycle until the end of treatment at intervals of 15 days.

6) Treatment progress:

Treatment progress days Purple Abdominal pain Arthritis & edema pulse 01 ++++ - VAS 3 (+) Bush cutting 08th +++ VAS 2 VAS 1 Bush cutting 20 days + VAS 1 VAS 1 Pulse is thin (浮 細) 41 days + VAS 1 - Pulse is thin (浮 細) 131 days - - - Pulse is slow

Referring to FIG. 4 and Table 4, on the first day, the patient was accompanied with pain and edema of both lower limbs and bilateral knee. The patient was suffering from a feverish period since he was a child. He was usually diagnosed with gait (虛 遲), 한 하였다 盜 (盜 汗) and dry stools, and with a macroscopic subarachnia (阴虛 火 动)

 Severe abdominal pain (VAS 4) before admission showed that he was admitted to the hospital for one day and received steroid treatment. The abdominal pain and joint swelling and pain were significantly improved (VAS 1). On the 20th day, there was almost no circulation, and on the 41th day it was completely gone. Frequent sore throat, weak abdominal pain appeared once but it disappeared spontaneously. Allergic purpura symptoms did not recur until 131th day and remained pulsatile.

5. Case 5

1) Sex and age: Male 6 years

2) Main symptoms: Not palpable, tickling.

3) Current history: 10 days before the onset of the disease, taking antibiotics and antipyretics with a cold. He was diagnosed with allergic purpura, and then received herbal medicine.

4) Other symptoms:

(1) Meals: Good.

(2) Digestion: Good.

(3) Stool: Dry stool.

(4) Urine: Good.

(5) Sleep: Good.

(6) Miscellaneous: Incumbency (五 心 热 熱), Dohan (盜汗) appeal. Non-bleeding complications.

5) Treatment content:

(1) Treatment of herbal medicine: Six packs of Gamitra yammi jiulhangang prepared in Example 1 were transferred to 30 cc / pack at 50 cc / pack.

6) Treatment progress:

Visiting day Purple Abdominal pain Arthritis & edema pulse Around 01 +++ - - Bush cutting Around the 14th + - - Bush cutting Around the 49th - - - Pulse is fine Around 84 - - - Pulse is fast (弦) About 105 days - - - Pulse is slow

Referring to Fig. 5 and Table 5, on the first day, the patient was in a state of bilateral pubic sympathetic dysgenesis. It was diagnosed as purpura due to the 阴虛 火 动 (阴虛 火 动) in consideration of the frequent nosebleed, frequent fever, and severe fever (盜汗) symptoms.

 She was suffering from a cold several days after her admission, but she was temporarily symptomatic. Her symptoms began to improve as she started taking herbal medicine. On the 49th day, the bladder completely disappeared, and on the 105th day, the vein was stable and the pulse was stable.

Especially in Case 3, untreated abdominal pain remained good after treatment with steroids.

6. Additional Cases

In addition to the above cases, the improvement of symptoms was confirmed from 20 patients with purpura who were further administered with Gamyungmi jiwanghangtang.

As a result, as shown in Table 6 and FIG. 6, in 20 cases, it was confirmed that most of the symptoms were improved at 90 days after the administration of the gummy eggs and jiwanghang tang.

division gender age On arrival 15th 30 days 45 days 60 days 75 days 90 days Case 1 south 5 8 8 3 5 3 One 0 Case 2 south 3 6 6 6 5 4 2 2 Case 3 female 8 3 3 4 2 One 0 0 Case 4 south 14 10 10 8 6 3 2 3 Case 5 female 7 8 8 7 5 3 One 0 Case 6 female 7 9 9 9 7 4 2 One Case 7 south 7 5 5 6 5 3 One 0 Case 8 female 9 7 7 4 5 3 One 0 Case 9 south 4 7 7 5 5 3 One 0 Case 10 south 5 9 9 6 5 3 One 0 Case 11 south 5 10 10 8 7 7 5 2 Case 12 female 11 7 7 7 5 5 One 0 Case 13 female 9 6 6 5 2 0 0 0 Case 14 south 10 8 8 3 2 One 0 0 Case 15 female 6 8 8 4 5 3 One 0 Case 16 south 7 9 9 5 5 3 One One Case 17 female 8 10 10 9 8 5 3 2 Case 18 female 8 5 5 3 3 2 One 0 Case 19 south 6 4 4 2 One 0 0 0 Case 20 south 9 6 7 5 5 2 One One

Taken together, the present invention is directed to a method for treating allergic purpuric symptoms in which allergic purpura has not recurred with the improvement of symptoms over time, It is confirmed.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it will be understood by those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention as defined in the appended claims. will be. Accordingly, the actual scope of the present invention will be defined by the appended claims and their equivalents.

Claims (6)

It was found that there were two species of Echinacea, including Rehmannia glutinosa, Dioscorea batatas DECNE, Macrocarpium officinale NAKAI, Poria cocos. (Schw.) Wolf, Moutan Root Bark and Alismatis Rhizoma. (Lactobacillus spp.), Angelica sinens (OLIV) DIELS, Astragalus membranaceus BUNGE, Glue, Lonicera japonica Thunb, Forthesia suspensa, Malt, Scrophularia burgeriana MIQ, (Bambusae). &Lt; RTI ID = 0.0 &gt; 21. &lt; / RTI &gt; The method according to claim 1,
The pharmaceutical composition for preventing or treating allergic purpura according to any one of claims 1 to 3, wherein the pharmaceutical composition comprises at least one selected from the group consisting of dried red ginseng, dried ginseng, corn oil, white berry ginseng, Korean ginseng, phytase, Angelica keiskei, 3. The method of claim 2,
With respect to 100 parts by weight of the total amount of the pharmaceutical composition,
5 to 15 parts by weight of dried persimmon;
5 to 15 parts by weight of an acid;
5 to 15 parts by weight of corn oil;
3 to 10 parts by weight;
3 to 10 parts by weight;
3 to 10 parts by weight of a taxane;
3 to 10 parts by weight of Angelica keiskei;
5 to 15 parts by weight of sulfur;
3 to 10 parts by weight of glue;
3 to 10 parts by weight of gold silver;
3 to 10 parts by weight of alum;
3 to 10 parts by weight of malt;
1 to 8 parts by weight of ginseng; And
And 1 to 8 parts by weight of a composition for preventing or treating allergic purpura. The method according to claim 1,
Wherein said pharmaceutical composition is taken in any one form selected from the group consisting of hot water, troche, capsules, oral tablets, granules, pills, powders, suspensions, and solvents, for the prevention or treatment of allergic purpura Composition. Characterized in that it further comprises at least one selected from the group consisting of Angelica keiskei, Angelica keiskei, Gypsum, Gilt Euphorbiaceae, Malt, Malachite, Health food for prevention or improvement of purpura. 6. The method of claim 5,
The health food for preventing or ameliorating allergy purpura characterized in that the health food includes dried persimmon, liquorice, corn oil, white bream, rhododendron, phytophthora, angelica, acanthopanax, glue, gilt eum, allium, malt, ginseng and killing.

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