KR20160058934A - 조직층을 가로질러 분자를 전달하기 위한 방법 및 장치 - Google Patents

조직층을 가로질러 분자를 전달하기 위한 방법 및 장치 Download PDF

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Publication number
KR20160058934A
KR20160058934A KR1020167010587A KR20167010587A KR20160058934A KR 20160058934 A KR20160058934 A KR 20160058934A KR 1020167010587 A KR1020167010587 A KR 1020167010587A KR 20167010587 A KR20167010587 A KR 20167010587A KR 20160058934 A KR20160058934 A KR 20160058934A
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South Korea
Prior art keywords
plasma
skin
molecule
molecules
plasma generator
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Withdrawn
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KR1020167010587A
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English (en)
Korean (ko)
Inventor
사미르 칼가티
다프네 파파스 안토나카스
충-찬 차이
로버트 엘. 그레이
Original Assignee
이피 테크놀로지스, 엘엘씨
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Publication of KR20160058934A publication Critical patent/KR20160058934A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/042—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating using additional gas becoming plasma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/44—Applying ionised fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H1/00—Generating plasma; Handling plasma
    • H05H1/24—Generating plasma
    • H05H1/2406—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452—Skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/1206—Generators therefor
    • A61B2018/122—Generators therefor ionizing, with corona
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10—General cosmetic use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/83—Electrophoresis; Electrodes; Electrolytic phenomena
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/04—Skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y10S977/774—Exhibiting three-dimensional carrier confinement, e.g. quantum dots
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plasma & Fusion (AREA)
  • Medical Informatics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Surgery (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nanotechnology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Otolaryngology (AREA)
  • Inorganic Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Birds (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Preparation (AREA)
KR1020167010587A 2013-09-27 2014-09-29 조직층을 가로질러 분자를 전달하기 위한 방법 및 장치 Withdrawn KR20160058934A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361883701P 2013-09-27 2013-09-27
US61/883,701 2013-09-27
PCT/US2014/058036 WO2015048637A1 (en) 2013-09-27 2014-09-29 Methods and apparatus for delivery of molecules across layers of tissue

Publications (1)

Publication Number Publication Date
KR20160058934A true KR20160058934A (ko) 2016-05-25

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KR1020167010587A Withdrawn KR20160058934A (ko) 2013-09-27 2014-09-29 조직층을 가로질러 분자를 전달하기 위한 방법 및 장치

Country Status (11)

Country Link
US (1) US20150094647A1 (cg-RX-API-DMAC10.html)
EP (1) EP3049058A1 (cg-RX-API-DMAC10.html)
JP (1) JP2016533326A (cg-RX-API-DMAC10.html)
KR (1) KR20160058934A (cg-RX-API-DMAC10.html)
CN (1) CN105658200A (cg-RX-API-DMAC10.html)
AU (1) AU2014324570A1 (cg-RX-API-DMAC10.html)
BR (1) BR112016006631A2 (cg-RX-API-DMAC10.html)
CA (1) CA2925621A1 (cg-RX-API-DMAC10.html)
IL (1) IL244732A0 (cg-RX-API-DMAC10.html)
MX (1) MX2016003876A (cg-RX-API-DMAC10.html)
WO (1) WO2015048637A1 (cg-RX-API-DMAC10.html)

Cited By (4)

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KR20180015060A (ko) * 2016-08-02 2018-02-12 주식회사 피글 플라즈마 치료 장치
KR20180015061A (ko) * 2016-08-02 2018-02-12 주식회사 피글 플라즈마 약물 적용 장치
KR102030528B1 (ko) * 2018-03-29 2019-11-08 주식회사 지씨에스 피부관리장치 및 그 장치의 구동방법
US11160726B2 (en) 2016-08-02 2021-11-02 Feagle Co., Ltd Plasma stimulation apparatus and acupuncture treatment apparatus including the same

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US20170135678A1 (en) 2015-11-18 2017-05-18 EP Technologies LLC Recovering analytes by reverse plasmaporation
US20170246440A1 (en) 2016-02-29 2017-08-31 EP Technologies LLC Apparatuses and methods for plasmaporation using microneedles
US10765850B2 (en) 2016-05-12 2020-09-08 Gojo Industries, Inc. Methods and systems for trans-tissue substance delivery using plasmaporation
WO2018089577A1 (en) 2016-11-10 2018-05-17 EP Technologies LLC Methods and systems for generating plasma activated liquid
WO2018207020A1 (en) * 2017-05-08 2018-11-15 L'oreal Cold atmospheric plasma treatment with chemical or organic compounds to modify the keratinous substrate microbiota
US12078154B1 (en) 2017-10-05 2024-09-03 The Board Of Trustees Of The University Of Alabama, For And On Behalf Of The University Of Alabama In Huntsville Microplasma-based heaterless, insertless cathode
FR3075012B1 (fr) 2017-12-20 2021-09-10 Oreal Procede de traitement cosmetique par plasma froid
KR102132370B1 (ko) * 2018-03-13 2020-08-05 주식회사 지씨에스 피부관리장치, 피부관리장치의 구동방법 및 컴퓨터 판독가능 기록매체
JP7152887B2 (ja) * 2018-07-03 2022-10-13 株式会社イノアックコーポレーション ダクト
CA3124411A1 (en) 2018-12-19 2020-06-25 ClearIt, LLC Systems and methods for tattoo removal using an applied electric field
EP3685779A1 (en) * 2019-01-24 2020-07-29 Universite Libre De Bruxelles Device for cold plasma treatment, cold plasma endoscopic system, and method for generating and transporting a cold plasma
CN111888641B (zh) * 2019-05-06 2023-09-22 上海肤泰科技有限公司 离子电渗透的给药装置
US11812540B1 (en) * 2019-09-30 2023-11-07 Board Of Trustees Of The University Of Alabama, For And On Behalf Of The University Of Alabama In Huntsville Continuous large area cold atmospheric pressure plasma sheet source
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US11458324B1 (en) 2021-10-12 2022-10-04 Andres Kaplan Cosmetic treatment for reducing body size
CN115282478B (zh) * 2022-08-08 2026-04-03 北京载愈生物科技有限公司 一种递送系统及递送方法
CN115591122A (zh) * 2022-10-10 2023-01-13 南京工业大学（Cn） 等离子体协同脉冲电场增强活性粒子组织渗透性的装置
JP2026507916A (ja) * 2023-03-10 2026-03-06 エイピーアール カンパニー リミテッド 目元肌管理のための肌美容器具及びそれを用いた目元肌管理施術方法
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180015060A (ko) * 2016-08-02 2018-02-12 주식회사 피글 플라즈마 치료 장치
KR20180015061A (ko) * 2016-08-02 2018-02-12 주식회사 피글 플라즈마 약물 적용 장치
US11160726B2 (en) 2016-08-02 2021-11-02 Feagle Co., Ltd Plasma stimulation apparatus and acupuncture treatment apparatus including the same
KR102030528B1 (ko) * 2018-03-29 2019-11-08 주식회사 지씨에스 피부관리장치 및 그 장치의 구동방법

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Publication number Publication date
CN105658200A (zh) 2016-06-08
BR112016006631A2 (pt) 2017-08-01
WO2015048637A1 (en) 2015-04-02
JP2016533326A (ja) 2016-10-27
AU2014324570A1 (en) 2016-05-12
EP3049058A1 (en) 2016-08-03
US20150094647A1 (en) 2015-04-02
CA2925621A1 (en) 2015-04-02
IL244732A0 (en) 2016-04-21
MX2016003876A (es) 2017-02-15

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