KR20160045726A - 면역조절제로서의 구형 핵산-기재 구축물 - Google Patents

면역조절제로서의 구형 핵산-기재 구축물 Download PDF

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KR20160045726A
KR20160045726A KR1020167004851A KR20167004851A KR20160045726A KR 20160045726 A KR20160045726 A KR 20160045726A KR 1020167004851 A KR1020167004851 A KR 1020167004851A KR 20167004851 A KR20167004851 A KR 20167004851A KR 20160045726 A KR20160045726 A KR 20160045726A
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average diameter
dna
nucleic acid
nanoscale
isp18
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Inventor
세르게이 그랴즈노프
크리스토퍼 씨. 메이더
티파니 엘. 할로
알렉산다르 필리프 라도비크-모레노
클레이턴 리셰
사가르 아난타트뮬라
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엑시큐어, 인크.
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    • A61K47/48861—
    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P37/08—Antiallergic agents
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/17—Immunomodulatory nucleic acids
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/30—Chemical structure
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    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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    • C12N2320/00—Applications; Uses
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KR1020167004851A 2013-07-25 2014-07-25 면역조절제로서의 구형 핵산-기재 구축물 Withdrawn KR20160045726A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361858584P 2013-07-25 2013-07-25
US61/858,584 2013-07-25
PCT/US2014/048294 WO2015013675A1 (en) 2013-07-25 2014-07-25 Spherical nucleic acid-based constructs as immunoregulatory agents

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KR20160045726A true KR20160045726A (ko) 2016-04-27

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KR1020167004851A Withdrawn KR20160045726A (ko) 2013-07-25 2014-07-25 면역조절제로서의 구형 핵산-기재 구축물

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US (1) US20160194642A1 (cg-RX-API-DMAC7.html)
EP (1) EP3024494A1 (cg-RX-API-DMAC7.html)
JP (1) JP2016534094A (cg-RX-API-DMAC7.html)
KR (1) KR20160045726A (cg-RX-API-DMAC7.html)
CN (1) CN105658241A (cg-RX-API-DMAC7.html)
AU (1) AU2014292928A1 (cg-RX-API-DMAC7.html)
CA (1) CA2919273A1 (cg-RX-API-DMAC7.html)
WO (1) WO2015013675A1 (cg-RX-API-DMAC7.html)

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AU2014292928A1 (en) 2016-03-03
JP2016534094A (ja) 2016-11-04
WO2015013675A1 (en) 2015-01-29
US20160194642A1 (en) 2016-07-07
EP3024494A1 (en) 2016-06-01
CN105658241A (zh) 2016-06-08
CA2919273A1 (en) 2015-01-29
WO2015013675A9 (en) 2016-04-28

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