KR20160039682A - 생물학적 샘플에서 개선된 성능을 가지는 timp2에 대한 검정 - Google Patents
생물학적 샘플에서 개선된 성능을 가지는 timp2에 대한 검정 Download PDFInfo
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- KR20160039682A KR20160039682A KR1020167005705A KR20167005705A KR20160039682A KR 20160039682 A KR20160039682 A KR 20160039682A KR 1020167005705 A KR1020167005705 A KR 1020167005705A KR 20167005705 A KR20167005705 A KR 20167005705A KR 20160039682 A KR20160039682 A KR 20160039682A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- G01N2333/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/34—Genitourinary disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361863073P | 2013-08-07 | 2013-08-07 | |
| US61/863,073 | 2013-08-07 | ||
| PCT/US2014/050195 WO2015021308A1 (en) | 2013-08-07 | 2014-08-07 | Assays for timp2 having improved performance in biological samples |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20160039682A true KR20160039682A (ko) | 2016-04-11 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020167005705A Withdrawn KR20160039682A (ko) | 2013-08-07 | 2014-08-07 | 생물학적 샘플에서 개선된 성능을 가지는 timp2에 대한 검정 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9879091B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3030582A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2016528236A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20160039682A (cg-RX-API-DMAC7.html) |
| CN (1) | CN105531291A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2014305883A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112016002685A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2920521A1 (cg-RX-API-DMAC7.html) |
| EA (1) | EA201690185A1 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1222180A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2016001573A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015021308A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (14)
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| US8778615B2 (en) | 2008-10-21 | 2014-07-15 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| NZ702527A (en) | 2009-12-20 | 2016-07-29 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| AU2011269775B2 (en) | 2010-06-23 | 2015-01-15 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| EP3540440B1 (en) | 2011-12-08 | 2022-09-28 | Astute Medical, Inc. | Methods and uses for evaluating renal injury and renal status |
| JP6681195B2 (ja) | 2013-01-17 | 2020-04-15 | アスチュート メディカル，インコーポレイテッド | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
| WO2015084939A1 (en) | 2013-12-03 | 2015-06-11 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| WO2016164854A1 (en) | 2015-04-09 | 2016-10-13 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US20170189908A1 (en) * | 2015-12-30 | 2017-07-06 | Bio-Rad Laboratories, Inc. | Droplet assay system with automatic calibration |
| EP3465201A4 (en) | 2016-06-06 | 2020-08-26 | Astute Medical, Inc. | MANAGEMENT OF ACUTE KIDNEY DAMAGE USING INSULINOMIMETIC GROWTH FACTOR BINDING PROTEIN 7 AND TISSUE METALLOPROTEINASE 2 INHIBITOR |
| WO2018006049A1 (en) * | 2016-06-30 | 2018-01-04 | The Research Foundation For The State University Of New York | Compositions and methods for modifying activity of extracellular mmp-2 |
| WO2018081578A1 (en) * | 2016-10-28 | 2018-05-03 | Astute Medical, Inc. | Use of antibodies to timp-2 for the improvement of renal function |
| US11346846B2 (en) | 2017-02-06 | 2022-05-31 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| WO2018187453A1 (en) * | 2017-04-05 | 2018-10-11 | Astute Medical, Inc. | Assays for timp2 having improved performance in biological samples |
| US11435364B2 (en) | 2018-05-24 | 2022-09-06 | Renibus Therapeutics, Inc. | Methods of treating patients at risk for renal injury and renal failure |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US459004A (en) | 1891-09-08 | Box for steaming cops | ||
| DE3029579C2 (de) | 1980-08-05 | 1985-12-12 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und Mittel zur Abtrennung von Plasma oder Serum aus Vollblut |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5028535A (en) | 1989-01-10 | 1991-07-02 | Biosite Diagnostics, Inc. | Threshold ligand-receptor assay |
| US5939272A (en) | 1989-01-10 | 1999-08-17 | Biosite Diagnostics Incorporated | Non-competitive threshold ligand-receptor assays |
| US5698671A (en) * | 1989-03-21 | 1997-12-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Metalloproteinase peptides |
| US5413923A (en) | 1989-07-25 | 1995-05-09 | Cell Genesys, Inc. | Homologous recombination for universal donor cells and chimeric mammalian hosts |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| DE69133566T2 (de) | 1990-01-12 | 2007-12-06 | Amgen Fremont Inc. | Bildung von xenogenen Antikörpern |
| US5922615A (en) | 1990-03-12 | 1999-07-13 | Biosite Diagnostics Incorporated | Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network |
| US5166051A (en) | 1990-08-08 | 1992-11-24 | Genesis Labs, Inc. | Membranes, membrane overlays for exclusion of erythrocytes, and method for immunoassay of whole blood analytes |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| WO1992003918A1 (en) | 1990-08-29 | 1992-03-19 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| WO1992005282A1 (en) | 1990-09-14 | 1992-04-02 | Biosite Diagnostics, Inc. | Antibodies to complexes of ligand receptors and ligands and their utility in ligand-receptor assays |
| US5955377A (en) | 1991-02-11 | 1999-09-21 | Biostar, Inc. | Methods and kits for the amplification of thin film based assays |
| ATE177841T1 (de) | 1991-04-10 | 1999-04-15 | Biosite Diagnostics Inc | ''crosstalk''- oder übersprech-inhibitoren und ihre verwendung |
| CA2107899A1 (en) | 1991-04-10 | 1992-10-11 | Gunars Edwin Valkirs | Novel conjugates and assays for simultaneous detection of multiple ligands |
| US6797492B2 (en) | 1991-05-17 | 2004-09-28 | Merck & Co., Inc. | Method for reducing the immunogenicity of antibody variable domains |
| CA2103059C (en) | 1991-06-14 | 2005-03-22 | Paul J. Carter | Method for making humanized antibodies |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| US6143576A (en) | 1992-05-21 | 2000-11-07 | Biosite Diagnostics, Inc. | Non-porous diagnostic devices for the controlled movement of reagents |
| US6019944A (en) | 1992-05-21 | 2000-02-01 | Biosite Diagnostics, Inc. | Diagnostic devices and apparatus for the controlled movement of reagents without membranes |
| US5494829A (en) | 1992-07-31 | 1996-02-27 | Biostar, Inc. | Devices and methods for detection of an analyte based upon light interference |
| US5824799A (en) | 1993-09-24 | 1998-10-20 | Biosite Diagnostics Incorporated | Hybrid phthalocyanine derivatives and their uses |
| US6562596B1 (en) * | 1993-10-06 | 2003-05-13 | Amgen Inc. | Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods |
| ATE390933T1 (de) | 1995-04-27 | 2008-04-15 | Amgen Fremont Inc | Aus immunisierten xenomäusen stammende menschliche antikörper gegen il-8 |
| WO1996034096A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6391265B1 (en) | 1996-08-26 | 2002-05-21 | Biosite Diagnostics, Inc. | Devices incorporating filters for filtering fluid samples |
| US6113855A (en) | 1996-11-15 | 2000-09-05 | Biosite Diagnostics, Inc. | Devices comprising multiple capillarity inducing surfaces |
| CA2722378C (en) | 1996-12-03 | 2015-02-03 | Amgen Fremont Inc. | Human antibodies that bind tnf.alpha. |
| US6045899A (en) | 1996-12-12 | 2000-04-04 | Usf Filtration & Separations Group, Inc. | Highly assymetric, hydrophilic, microfiltration membranes having large pore diameters |
| US5947124A (en) | 1997-03-11 | 1999-09-07 | Biosite Diagnostics Incorporated | Diagnostic for determining the time of a heart attack |
| US6057098A (en) | 1997-04-04 | 2000-05-02 | Biosite Diagnostics, Inc. | Polyvalent display libraries |
| AU8489698A (en) * | 1997-07-16 | 1999-02-10 | Charm Sciences, Inc. | A test device and method for detecting the presence of a residue analyte in a sample |
| AU3185199A (en) * | 1998-03-16 | 1999-10-11 | Quidel Corporation | Immunoassay device and method |
| US7214542B2 (en) * | 2003-01-30 | 2007-05-08 | Michael Hutchinson | Method of processing assay test results |
| WO2004096832A2 (en) | 2003-04-29 | 2004-11-11 | Children's Medical Center Corporation | Novel antiangiogenic peptides |
| WO2005015217A1 (ja) * | 2003-08-11 | 2005-02-17 | Kyowa Medex Co., Ltd. | 測定対象物測定器具、測定装置および測定方法 |
| CA2574417C (en) | 2004-07-28 | 2010-09-28 | F. Hoffmann-La Roche Ag | Timp-2 as target/marker of beta cell failure |
| US7485468B2 (en) * | 2004-10-15 | 2009-02-03 | Galapagos Bv | Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases |
| WO2007048102A2 (en) * | 2005-10-18 | 2007-04-26 | The Government Of The United States, As Represented By The Secretary Of Health And Human Services | Angio-inhibitory peptides derived from human timp-2 |
| US8778615B2 (en) | 2008-10-21 | 2014-07-15 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US8900881B2 (en) * | 2008-12-30 | 2014-12-02 | Jin Po Lee | Quantitative analyte assay device and method |
| NZ702527A (en) | 2009-12-20 | 2016-07-29 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CN103069277B (zh) * | 2010-03-31 | 2016-03-30 | 积水医疗株式会社 | 利用免疫色谱法的测定法、免疫色谱测试条和用于免疫色谱法的测定试剂盒 |
-
2014
- 2014-08-07 JP JP2016533450A patent/JP2016528236A/ja active Pending
- 2014-08-07 EP EP14834090.4A patent/EP3030582A4/en not_active Withdrawn
- 2014-08-07 BR BR112016002685A patent/BR112016002685A2/pt not_active Application Discontinuation
- 2014-08-07 EP EP19183111.4A patent/EP3617234A1/en not_active Withdrawn
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- 2014-08-07 HK HK16110255.1A patent/HK1222180A1/zh unknown
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- 2014-08-07 MX MX2016001573A patent/MX2016001573A/es unknown
- 2014-08-07 CN CN201480048192.1A patent/CN105531291A/zh active Pending
- 2014-08-07 CA CA2920521A patent/CA2920521A1/en not_active Abandoned
- 2014-08-07 US US14/910,661 patent/US9879091B2/en active Active
- 2014-08-07 KR KR1020167005705A patent/KR20160039682A/ko not_active Withdrawn
- 2014-08-07 EA EA201690185A patent/EA201690185A1/ru unknown
-
2018
- 2018-01-29 US US15/882,936 patent/US10457744B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN105531291A (zh) | 2016-04-27 |
| EP3030582A1 (en) | 2016-06-15 |
| CA2920521A1 (en) | 2015-02-12 |
| MX2016001573A (es) | 2016-09-07 |
| US20180162953A1 (en) | 2018-06-14 |
| AU2014305883A1 (en) | 2016-02-25 |
| EA201690185A1 (ru) | 2016-07-29 |
| WO2015021308A1 (en) | 2015-02-12 |
| JP2016528236A (ja) | 2016-09-15 |
| EP3030582A4 (en) | 2017-05-17 |
| US20160297893A1 (en) | 2016-10-13 |
| HK1222180A1 (zh) | 2017-06-23 |
| EP3617234A1 (en) | 2020-03-04 |
| US9879091B2 (en) | 2018-01-30 |
| US10457744B2 (en) | 2019-10-29 |
| BR112016002685A2 (pt) | 2018-01-30 |
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| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20160302 Patent event code: PA01051R01D Comment text: International Patent Application |
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| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |