KR20160009345A - Composition having effects of preventing hangover, relieving hangover, protecting hepatic or recovering fatigue by alcoholintake - Google Patents

Abstract

The present invention relates to a composition to prevent or relieve alcohol induced hangover, liver diseases or fatigue. According to the present invention, the composition to prevent or relieve alcohol induced hangover, to protect liver, or to recover from fatigue comprises: as an active ingredient, decursin and/or decursinol angelate, or an angelica gigas NAKAI extract including decursin and/or decursinol angelate as an active ingredient; a rice embryo-bud extract; and a daikon dried extract. Decursin and/or decursinol angelate can be desirably obtained by extraction, separation and purification from angelica gigas NAKAI, and the extracts of rice embryo-buds and dried daikon are desirably obtained based on hot water extraction with purified water at the temperature equal or above 100°C. The composition according to the present invention can be used for a pharmaceutical formulation by including pharmaceutically acceptable carriers or additives, or for a functional food for health by including pharmaceutically acceptable food additives.

Description

Preventing hangover, hangover, soy sauce or soy sauce containing as an active ingredient angelica extract, decanthraquinone and / or dexacinol angelate or dexacin and / or dexacinol angelate as active ingredients; [0001] The present invention relates to a composition for restoring fatigue,

The present invention relates to a composition for preventing or eliminating a hangover, liver disease or fatigue induced by alcohol ingestion, and more particularly to a composition for preventing or eliminating hangch, liver disease or fatigue induced by alcohol ingestion, The present invention also relates to a composition for prevention of hangover, hangover resolution, liver protection, and fatigue recovery, which comprises Angelica keiskei Radix extract, Rice's eye extract and Radish extract as an active ingredient.

 Alcohol is generally called ethyl alcohol, and most of it is used as alcohol. These alcohols are becoming more important in terms of social or toxicological properties as a tasty drink than drugs.

Alcohol is a water-soluble small molecule that is rapidly absorbed in the gastrointestinal tract. In the fasting state, the maximum blood concentration is reached within 30 minutes, but the rate of absorption depends on the amount of food in the stomach. Alcohol ingested is partially degraded in the stomach and intestines and is transported to the bloodstream, where 90-98% is oxidized in the liver and the remaining 2-10% is excreted in the lungs and urine. The rate of alcohol metabolism in normal adults is about 10 to 15 gm per hour. The main enzyme involved in the metabolism of alcohol is alcohol dehydrogenase (ADH), which is the metabolite of this reaction. Acetaldehyde is produced and then oxidized to acetate by acetaldehyde dehydrogenase . Alcohol, on the other hand, may be metabolized to acetaldehyde by the microsomal ethanol oxidizing system (MEOS). When chronically alcohol is consumed, the activity of the bovine ethanolic oxidation system (MEOS) enzyme system is increased rather than the alcohol metabolism pathway, alcohol dehydrogenase (ADH).

Often alcohol is thought to stimulate the central nervous system, in fact, alcohol has central nervous system suppression. The central nervous system suppression effect appears in the brain nervous system from the site of the integration function and is proportional to the dose. When a small amount is taken, suppression mechanism of brain mental and behavior is suppressed, and some excitement may appear. However, as the blood concentration increases, it becomes more aggressive, aggressive, and loss of controllability as well as excitement and sense of exhaustion. Depending on the person, there may be differences depending on the usual education, culture, and experience, but delicate judgment, memory, and concentration are gradually reduced. I feel confident in everything, I get more words and I feel confident that I can do anything, but in fact the intellectual and motor efficiency is rather reduced. These symptoms are proportional to the alcohol concentration in the blood and are accompanied by crying or smiling emotional disturbances regardless of the surrounding environment. Because alcohol is a nonspecific central nervous system inhibitor, high doses can lead to deep anesthesia, such as general anesthetics or sleeping pills. High doses can lead to coma, respiratory depression, and death.

The liver is the most damaged organ due to alcohol. Even if you do not have any external findings, if you drink alcohol, clinically meaningful liver disease occurs without you knowing. Acetaldehyde, a middle product of alcohol, is a very toxic, highly reactive compound that promotes the peroxidation of fat and damages the mitochondria. The formation of acetaldehyde-protein complexes promotes the production of collagen and stimulates liver inflammation. Alcohol is independent of gastric acid secretion, but gastritis is prone to develop in chronic alcoholics and can lead to anemia and malnutrition due to the loss of blood and plasma proteins during drinking. If the toxic free radicals can not be removed due to a lack of essential factors such as glutathione due to malnutrition, liver damage becomes worse.

Hangover, on the other hand, is a phenomenon in which symptoms such as alcoholic symptoms, discomfort or headache after drinking from a drink and feeling awake from sleep, or declining work capacity of mind and body. The reason is that alcohol is decomposed into acetaldehyde and accumulates in the body to continuously stimulate the liver and nerves, the stomach, and the skeletal muscle. Symptoms of hangover include acute vasodilation. Gastrointestinal symptoms such as diarrhea, irritability, anorexia, aggressive, loss of behavioral control, headache, shaking. The symptoms of cardiovascular circulatory system such as flushing, heart palpitations, skin warmth, Anesthetic symptoms such as nervous system symptoms, confusion, anesthesia state, coma, respiratory depression, etc., such as amnesia, loss of brain function, delicate judgment, memory deterioration, , Physical fatigue and other symptoms such as musculoskeletal, polyuria, diuretic, thirst, dehydration, and so on. Chronic reactions include fatty liver, liver cirrhosis, sexual dysfunction, and neuromuscular disorders.

Alcohol breakdown is done in the liver, so in order to resolve the hangover, improve the liver function, or alcohol and aldehyde degrading enzyme to help the production of ingredients is the principle. Typical hangover foods include bean sprouts soup, burger soup, shellfish soup, honey, citron tea, and green tea.

The present invention is to provide a composition for preventing or eliminating hangover, liver disease, fatigue and the like caused by alcohol. Specific technical problems are as follows.

First, it is intended to provide a novel composition capable of protecting hepatocytes and the like by rapidly metabolizing acetaldehyde, which is a toxic substance caused by alcohol consumption, by preventing mitochondria damage caused by the toxin.

Second, the present invention provides a composition capable of effectively preventing and eliminating a hangover phenomenon caused by alcohol absorption.

Third, it is intended to provide a composition for prevention of hangover, hangover, liver protection or fatigue recovery which has no side effects to human body.

In order to solve the above-mentioned technical problems, the present invention provides a method for the treatment and / or prevention of angiogenesis, which comprises administering to a mammal an effective amount of angiotensin converting enzyme inhibitor, angiotensin converting enzyme inhibitor, angiotensin converting enzyme inhibitor, Rice husk extract; And a non-alcoholic extract; and a composition for preventing alcoholic hangover, hangover, liver protection or fatigue recovery.

Decarkin and / or decercinol angelate can be obtained from Angelica gigas by extraction, separation and purification. Specific extraction and purification methods are described in Ji Hyung Jun et al., Biochemical Journal, 1, 25-32 (1970) and Korean J. Pharmacogn., 21, 64-68 (1990)) and Patent Registration No. 10-2385092, but the present invention is not limited thereto. Any extraction method capable of obtaining dexacinol angelate is possible. Also, in the present invention, deckacin and / or decancinol angelate may be used in a state containing other substances added in the process for extracting Angelicae gigantis, such as salts, organic salts, complexes and the like. (Tetsuhiro Nemoto et al., Tetrahedron Letters, 41, 9569-9574 (2000); Lan Xie et al., J. Med. Chem , Patent Application No. 2000-25749 and Patent Registration No. 10-0417624), but the present invention is not limited thereto, and even if the synthesis conditions and the like are different, Any synthesis method capable of obtaining nol angelate can be used. On the other hand, the deacquin and / or decancinol angelate comprises an inorganic salt selected from the group consisting of sodium salt, potassium salt, magnesium salt and calcium salt or a salt of lysine, ethanolamine, N, N'-dibenzylethylenediamine Or a pharmaceutically acceptable salt such as an organic salt selected from the group consisting of

The rice gruel is preferably a hot-water extract extracted from purified water at 100 ° C or higher. More preferably, the rice husk is added to purified water having a concentration of 30-40 times and heated at 100 ° C or higher for 8-12 hours. Under such extraction conditions, various active ingredients including the rice husk can be extracted. The main active ingredients in rice ginseng include GABA (improving learning and memory capacity, reducing stress, improving liver function), octagolanol (physiological activity, improving endurance, decreasing body fat and increasing muscle mass), alpha-tocopherol ), Gamma oryzanol (Brain nutrition supply, Energy metabolism promotion, Obesity prevention), Dietary fiber (Enhancement of intestinal microorganism, Constipation prevention, Colonization activity function), Vitamin B1 Vitamin B6 (Promotion of Protein Nucleic Acid Metabolism, Anti-Aging, Neurological Disorders), Linoleic Acid (Skin Nutrition, Growth Promotion) ).

The non-salted extract is preferably a hot-water extract extracted from purified water at a temperature of 100 ° C or higher, more preferably a salted salmon is put into 500 to 600-fold purified water and heated at 100 ° C or higher for 8 to 12 hours for extraction. It contains iron, calcium, and dietary fiber. It is good for atopic, allergic skin, blood circulation, prevents aging of cells, has diuretic and anti-inflammatory action, and is good for digestion and absorption of intestinal waste.

The composition according to the present invention may be provided as a pharmaceutical preparation further comprising a pharmaceutically acceptable carrier or a pharmaceutical additive, or may be provided as a health functional food further including a pharmaceutically acceptable food additive. The present invention exemplifies a health functional drink containing at least one of diastase, GABA, Glutathione, aspartic acid, methionine, taurine, fructose, vitamin C, vitamin B, catechin, mineral, citric acid, herb flavor, sodium citrate and sweetener as food additives. . As the sweetener, brown sugar and / or enzyme-treated stevia may be selected.

According to the present invention, the following effects can be expected.

First, the composition according to the present invention showed excellent preventive and remedial action against the hangover symptom, and it was confirmed that it exhibited the toxic effect of acetaldehyde to cause hangover, liver disease, fatigue and the like when alcohol was consumed, It can be advantageously used in various pharmaceuticals and food compositions for hangover, soy sauce protection, fatigue recovery and the like.

Second, it is expected that the composition according to the present invention can be safely used in the human body since it has been confirmed that there is no adverse effect in the animal toxicity test.

FIG. 1 is a graph showing the change in ADH activity, which is an alcohol degradation ability, according to administration of a composition according to the present invention in an animal experiment.
FIG. 2 is a graph showing change in blood alcohol concentration according to administration of the composition according to the present invention in an animal experiment. FIG.
3 is a graph showing changes in blood acetaldehyde concentration with time after administration of the composition according to the present invention in an animal experiment.
FIG. 4 is a graph showing change in blood alcohol concentration over time according to drinking after taking a composition according to the present invention before drinking in a human body experiment.
FIG. 5 is a graph showing subjective evaluation results of the hangover phenomenon of an experimenter according to drinking after taking a composition according to the present invention before drinking in a human body experiment.
FIG. 6 is a graph showing an objective questionnaire evaluation result of a hangover phenomenon according to drinking after taking a composition according to the present invention before drinking in a human body experiment. FIG.
FIG. 7 is a graph showing the results of subjective questionnaire evaluation by an experimenter of a hangover phenomenon due to drinking the next day after taking the composition according to the present invention before drinking in a human body experiment.
8 is a graph showing changes in blood alcohol concentration with time according to the composition of the present invention after drinking in a human body experiment.
FIG. 9 is a graph showing the results of subjective questionnaire evaluation by an experimenter of a hangover phenomenon due to drinking the next day after taking a composition according to the present invention after drinking in a human body experiment.

Hereinafter, the present invention will be described in detail based on examples. However, the following examples are for illustrative purposes only and are not intended to limit the scope of the present invention.

[Example 1] Preparation of composition

The composition according to the present invention was mixed with a composition as shown in Table 1 below to prepare a beverage. The composition ranges below are the result of comprehensive consideration of functionality and sensibility.

Composition of composition (% by weight) material Composition range Composition ratio Remarks Active ingredient The extract of Angelica gigas Nakai, which contains deckacin and / or decercinol angelate or deckacin and / or dexacinol angelate as active ingredients 0.01 to 10 0.8 The Korean red ginseng extract was cultivated and extracted according to the method described in Patent Registration No. 10-0385092 Rice eye extract 0.01 to 20 4 300 g of rice flour was added to 11000 g of purified water and the extract solution was extracted at 100 ° C. or higher for 10 hours Welsh onion extract 0.01 to 20 0.2 20 g of salted red wool was added to 11000 g of purified water, and the extract solution was extracted at 100 ° C. or higher for 10 hours additive Multivitamin 0.01 to 5 0.06 GABA, Glutathione, Aspartic acid, Methionine, Taurine, Fructose (honey), Vitamin C, Vitamin B, Catechin, Minerals, Sweetener, Citric acid, Herb incense, Sodium citrate sweetener 0.01 to 5 4 Brown sugar water 50 to 99.96 90.94 Purified water Sum 100 100 -

[Example 2] Animal experiment

1. Determination of the activity of alcohololytic enzyme acetaldehyde (ADH)

(1) Experimental method

The ADH activity measurement for the compositions in the present invention was performed according to the method provided using an acetaldehyde assay kit. The composition (experimental group) and the control group (purified water) were diluted in a digestion buffer and placed in 96-well multiwell plates in 50 ul increments. A mixed solution of 82 uL of degradation buffer and 8 uL of developing solution and 10 uL of isopropanol was added to the plate do. Thereafter, the cells were incubated at 37 ° C for 3 minutes and reacted, and the amount of ADH produced was measured. The absorbance was measured at 450 nm using an ultraviolet spectrophotometer. After 30 min incubation, the amount of ADH produced was measured, and the alcoholysis activity was calculated using the two equations given in the kit.

(2) Experimental results

When the absorbance of the solvent control was taken as 1, the relative absorbance of the composition was expressed, and the activity of the composition was expressed as a relative ratio to the control using purified water as a control. The results are shown in Table 2 below and FIG.

Changes in ADH activity, which is the alcohol degradation ability, by administration of the composition Control group Experimental group Average 1.00 3.02 Standard Deviation 0.00 0.30

As shown in Table 1 and FIG. 1, the present composition showed statistically significant ADH activity as compared with the control group. Accordingly, it can be seen that the composition according to the present invention has an effect of preventing the toxicity of acetaldehyde which causes hangover, fatigue and liver disease when consumed with alcohol. In other words, since the effect of accelerating the activity of the alcoholase, ADH, is excellent, the ethanol is rapidly decomposed into acetic acid, which is the final metabolite, so that the prevention and improvement of various diseases caused by alcohol consumption can be expected.

2. Blood Alcohol and Acetaldehyde Concentration Changes

(1) Experimental method

In order to confirm the alcohol decomposition effect of the composition according to the present invention, the composition was administered to the rats together with the alcohol, and the concentration of alcohol and acetaldehyde in the blood was measured to evaluate the alcohol decomposition effect. 3-ml per kg of 40% alcohol was orally administered to 6-week-old SD rats at birth, and 3 ml of the composition according to the present invention was orally administered at 30 minutes before and after the alcohol administration. Purified water was used as a control.

After 1, 3, and 5 hours after alcohol administration, 0.2 ml of blood was collected from the subclavian vein and serum was separated to measure blood alcohol concentration and acetaldehyde concentration. In order to measure the serum alcohol concentration by time, the blood was immediately centrifuged and the upper plasma was placed in a sealed tube and stored in a -70 ° C freezer. The samples were analyzed by EnzyChrom Ethanol Assay Kit and absorbance was measured at 570 nm.

(2) Change in blood alcohol concentration

The blood alcohol concentration according to administration of the composition according to the present invention was measured as shown in [Table 3] and FIG. 2 below.

Change in blood alcohol concentration 1 hours 3 hours 5 hours Control group Average 0.03 0.03 0.02 Standard Deviation 0.01 0.01 0.00 Experimental group Average 0.02 0.01 0.01 Standard Deviation 0.01 0.00 0.00

As shown in [Table 3] and FIG. 2, the composition according to the present invention showed a significant decrease in blood alcohol concentration over time as compared with the control group, and thus it was confirmed that the effect of lowering the alcohol concentration in blood was excellent.

(3) Change in blood acetaldehyde concentration

The concentrations of acetaldehyde in the blood according to the administration of the composition according to the present invention were measured as shown in [Table 4] and FIG. 3 below.

Change in blood acetaldehyde concentration (mg / L) 1 hours 3 hours 5 hours Control group Average 8.52 7.40 6.10 Standard Deviation 0.39 0.44 0.18 Experimental group Average 5.14 3.50 1.50 Standard Deviation 0.54 0.33 0.45

As shown in [Table 4] and FIG. 3, the composition according to the present invention showed a marked decrease in blood acetaldehyde concentration over time as compared with the control group, and thus it was confirmed that the effect of lowering the concentration of acetaldehyde in blood was excellent.

(4) Sintering

As a result of the above experiment, it was confirmed that the concentration of alcohol and acetaldehyde of the present composition according to the present invention was significantly decreased over time as compared with the control group. Accordingly, the composition according to the present invention can be said to have an effect of preventing acetaldehyde toxicity which causes hangover, fatigue and liver disease.

3. Toxicity experiment

(1) Experimental method

Six - week old SD rats were used for acute toxicity tests. The composition of the present invention was dissolved in 5 rabbits of each group, and the composition was administered once at a dose of 1 g / kg / ml for 9 days. After administration of the composition according to the present invention, mortality, clinical symptoms and weight changes of the animals were observed, hematologic tests and blood biochemical tests were performed, and autopsy was performed to visually examine the abdominal organs and thoracic organs.

(2) Experimental results

As a result of the administration of the composition according to the present invention, there were no dead rats, and all rats were in good health during visual observation. After administration of the composition according to the present invention, there was no significant clinical symptoms other than slight increase in body weight in all rats, and normal activities were normal. In addition, no specific findings were observed in blood tests and blood biochemical tests. After 9 days, all mice were dissected and examined for each tissue and organs. No abnormalities were found in all tissues and organs. Therefore, it can be seen that the composition according to the present invention is safe for human body.

[Example 3] Human body experiment

1. Outline of experiment

(1) Experimental method

Before and after drinking, the beverage prepared according to [Example 1] was taken and the effect was evaluated. To evaluate the effects of hangover prevention and elimination, liver protection and fatigue recovery, experimental and control groups were divided into two groups.

(2) Target

Twenty healthy 20 - year - old male adults with normal body weight, ranging from 1.5 to 2 bottles of soju, without any physical history such as heart, lung, liver, kidney and brain were tested. After the experiment, 5 experimental group and 5 control group were used and blind test was performed.

(3) drinking

A total of 144 mL of ethanol (2 mL of total soju (720 mL) of ethanol) per kg body weight of 2.6 g alcohol / kg body weight was allowed to drink for 120 minutes.

(4) Questionnaire

The degree of each item was set to a scale of 5 steps (1 to 5) with a minimum value of 1 and a maximum value of 5.

2. Prevention of hangover by taking composition before drinking

(1) Experimental method

At 7 pm, each test group received the composition and the control group received purified water. In the experimental group and the control group, after 30 minutes, all subjects were allowed to eat one cup of shochu for 120 minutes. The selection of subjects was as shown in Table 5 below, and there was no significant difference between the two groups in the subjects.

Subject age weight Average Standard Deviation Average Standard Deviation Experimental group 35.40 9.86 66.80 7.89 Control group 36.20 9.81 65.00 8.28

(2) Changes in Blood Alcohol Concentration

In the experimental group, alcohol was taken 30 minutes after taking the composition, and then 30 minutes after the last drinking, blood alcohol concentration was measured at intervals of 30 minutes for 120 minutes. In the control group, purified water was used. Blood alcohol concentration was measured by using a breathalyzer. The results are shown in Table 6 and FIG. 4 below.

Changes in Exhaled Blood Alcohol Concentration by Time (%) 30 minutes 60 minutes 90 minutes 120 minutes Control group Average 0.28 0.27 0.26 0.25 Standard Deviation 0.01 0.01 0.01 0.01 Experimental group Average 0.25 0.23 0.2 0.17 Standard Deviation 0.01 0.01 0.01 0.01

As shown in Table 6 and FIG. 4, when the composition according to the present invention was administered before drinking, the blood alcohol level was lowered statistically significantly after 30 minutes compared to the control group, and the blood alcohol level I could. It can be said that the composition according to the present invention is effective for prevention of hangover when it is taken before drinking.

(3) subjective assessment of the effect of preventing hangover

In the experimental group, alcohol was taken 30 minutes after taking the composition, and 2 hours after the last drinking, the questionnaire was questioned about the hangover phenomenon due to drinking. The control group received purified water. The questionnaire was used to evaluate the items such as odor, excitement, chest throbbing, nausea and vomiting, and skin warmth. The evaluation results are shown in [Table 7] and FIG. 5 below.

Subjective evaluation of hangover phenomenon Odor Excitement Heart beating Nausea vomiting Skin warmth Control group Average 4.60 4.20 3.40 3.60 4.20 Standard Deviation 0.55 0.84 0.55 0.55 0.45 Experimental group Average 2.80 3.20 2.60 2.40 2.80 Standard Deviation 0.45 0.45 0.55 0.55 0.45

As shown in Table 7 and FIG. 5, when the composition according to the present invention was used before drinking, the odor was significantly lower than the control group, and excitement, chest puckering, nausea vomiting and skin warming were significantly decreased . That is, the composition according to the present invention is effective for prevention of hangover by taking it before drinking.

(4) Objective evaluation of hangover symptoms for the experimenter

In the experimental group, alcohol was taken 30 minutes after taking the composition, and 2 hours after the last drinking, the behavior change was objectively evaluated in the hanging phenomenon due to drinking. The control group received purified water. Evaluations were evaluated by the researchers about the smell of alcohol, the increase of the horse, the face flushing, the cognitive function, the concentration decrease, the walking disorder, The evaluation results are shown in [Table 8] and FIG. 6 below.

Objective questionnaire evaluation of hangover phenomenon Liquor smell More words Face flush Cognitive impairment Decreased concentration Decreased walking ability confusion Control group Average 4.80 4.20 4.20 4.80 4.40 4.60 3.20 Standard Deviation 0.45 0.84 0.45 0.45 0.55 0.55 0.84 Experimental group Average 3.40 3.80 3.80 3.20 3.20 3.00 2.40 Standard Deviation 0.55 0.84 0.45 0.84 0.84 0.71 0.55

As shown in [Table 8] and FIG. 6, the composition before drinking was significantly less in the smell of the alcoholic beverage, less in the number of horses, and less in the face flushing than in the control group. The cognitive function which can accurately recognize people according to the composition before drinking was also meaningful. When walking test was performed 2 hours later, gait strength was better than control group. Therefore, the composition according to the present invention can be said to be effective for prevention of hangover by taking it before drinking.

(5) Subjective evaluation of the experimenter the next day

In the experimental group, alcohol was taken 30 minutes after taking the composition, and the hangover phenomenon due to drinking at the morning of the next day after sleeping was evaluated as a questionnaire. The control group received purified water. The evaluation questionnaire evaluated the items such as thirst, anorexia, heartburn, memory loss, headache, stamina and fatigue. The evaluation results are shown in Table 9 and FIG. 7 below.

Subjective questionnaire evaluation of the hangover phenomenon by drinking the next day thirst Anorexia water brash Memory loss headache Stunted fatigue Liquor smell Control group Average 4.80 3.80 3.80 3.80 4.00 4.60 4.40 3.00 Standard Deviation 0.45 0.84 0.45 0.84 0.71 0.55 0.55 0.45 Experimental group Average 3.20 3.20 3.20 3.00 2.60 2.60 2.40 1.80 Standard Deviation 1.30 0.84 0.84 0.71 0.89 0.89 1.14 0.45

As shown in [Table 9] and FIG. 7, when the composition according to the present invention was taken before drinking and the questionnaire about the effect of hangover on each experimental group was examined on the day after drinking, it was found that hangover symptoms, , Memory impairment, headache, stunning, and fatigue were significantly lower in the group taking the composition before drinking than in the control group. Therefore, the composition according to the present invention can be said to be effective for prevention of hangover by taking it before drinking.

3. Effect of taking a composition after drinking to relieve hangovers

(1) Experimental method

10 subjects were divided into experimental group (5 persons) and control group (5 persons) at 7:00 pm. Each group was allowed to eat one cup of shochu for 120 minutes and 30 minutes after the last drinking group, Control group was started by taking purified water. The selection of subjects was as shown in [Table 10], and there was no significant difference between the two groups in the subjects.

Subject age weight Average Standard Deviation Average Standard Deviation Experimental group 36.8 10.2 67.81 66.41 Control group 38.8 7.04 7.25 8.96

(2) Changes in Blood Alcohol Concentration

At 30 minutes after drinking, the test group measured the blood alcohol level from 30 minutes to 120 minutes at intervals of 30 minutes. The control group received purified water. Blood alcohol concentration was measured by using a breathalyzer. The results are shown in Table 11 and FIG. 8 below.

Changes in Blood Alcohol Concentration (% Alcohol) 30 minutes 60 minutes 90 minutes 120 minutes Control group Average 0.29 0.28 0.27 0.26 Standard Deviation 0.01 0.01 0.01 0.01 Experimental group Average 0.27 0.24 0.21 0.18 Standard Deviation 0.01 0.02 0.01 0.01

As shown in [Table 11] and FIG. 8, the composition according to the present invention showed significantly lowered blood alcohol concentration over time as compared with the control group after drinking, . In particular, the composition of the present invention was found to have a blood alcohol concentration of less than 0.05% after 1 hour of ingestion. Therefore, it can be said that the composition according to the present invention is effective for taking a hangover after drinking.

(3) Evaluation of hangover elimination effect

30 minutes after drinking, the following day, I questioned the hangover phenomenon due to drinking at dawn. Using the questionnaire, the subjects evaluated the items such as aches, nausea, vomiting, thirst, anorexia, memory impairment, headache, stamina, fatigue, and alcohol smell. The evaluation results are shown in Table 12 and FIG. 9 below.

Subjective questionnaire evaluation of the hangover phenomenon by drinking the next day Control group Experimental group Average Standard Deviation Average Standard Deviation Odor 2.40 0.55 0.80 0.45 Nausea vomiting 2.50 0.50 1.50 0.50 thirst 4.70 0.67 3.30 0.67 Anorexia 3.90 0.74 3.30 0.67 water brash 3.90 0.22 3.30 0.45 Memory loss 3.90 0.74 3.10 0.65 headache 3.90 0.74 2.70 0.84 Stunted 4.50 0.50 2.70 0.84 fatigue 4.30 0.45 2.50 1.00 Liquor smell 2.90 0.22 2.00 0.71

As shown in Table 12 and FIG. 9, when the composition according to the present invention was administered after drinking, the degree of odor was less than that of the control group, and hangover symptoms such as sickness vomiting, thirst and heartburn headache fatigue were significantly . Accordingly, the composition according to the present invention can be said to be effective in eliminating hangover after drinking.

Claims (4)

Angelica angustifolia, decaccin and / or decancinol angelate, or decaccin and / or decascinol angelate as active ingredients; Rice husk extract; And a non-alcoholic extract; and a composition for preventing alcoholic hangover, hangover, liver protection or fatigue recovery. The method of claim 1,
A composition for the prevention of alcoholic hangovers, hangovers, hepatic protection or fatigue, further comprising a pharmaceutically acceptable carrier or a pharmaceutical additive, or a pharmaceutically acceptable food additive. 3. The method of claim 2,
Wherein the food additive is at least one selected from diastase, GABA, Glutathione, aspartic acid, methionine, taurine, fructose, vitamin C, vitamin B, catechin, mineral, citric acid, herb flavor, sodium citrate, , Hangover, liver protection or fatigue recovery. 4. The method of claim 3,
Wherein the sweetener is a brown sugar and / or an enzyme-treated stevia, wherein the composition is for prevention of alcoholic hangover, hangover, liver protection or fatigue recovery.

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