KR20150122345A - Skin Moisturizer and penetration enhancer with the distilled mineral water from thermal seawater - Google Patents

Abstract

Provided are a skin moisturizer and a percutaneous absorption enhancer including mineral water obtained by treating hot seawater of Yonggung spa in Seongmo Island, Ganghwa-gun by a mechanical steam recompressing method.

Description

[0001] The present invention relates to a skin moisturizing agent and a transdermal absorption enhancer containing mineral active water obtained from seawater hot spring water,

The present invention relates to a skin moisturizing agent and a transdermal absorption promoter containing mineral active water obtained from seawater hot spring water.

Hot springs are "hot water over 25 degrees Celsius which is eluted from underground, whose constituents are not harmful to human body" or more specifically, hot water, mineral water, water vapor and other gases eluted from underground, 25 degrees or more and having at least one specific dissolved substance ". There are a total of 176 hot springs in the country with 404 hot springs (as of December 31, 2007) and 520 hot springs (September 30, 2008). The classification of water quality characteristics of domestic hot springs is classified into 263 (65.10%), 84 (20.79%) of low temperature springs (20.79%) in Gwangcheon hot spring There are 223 alkaline hot springs, 132 weak alkaline hot springs, 48 neutral hot springs, 24 springs (3.28%), 27 springs (6.68%), 17 sulfur springs (4.21%) and 13 carbonate springs , And one acidic hot spring is not distributed. The type of water _{Na-HCO 3, Na-Cl} , Na-SO 4, Ca-HCO 3, Ca-Cl, Na-CO 3, Ca-SO 4, and the Mg-HCO ₃ type is present, containing a specific component , The type of Li, Sr, Fe, Mn,

The medical use of hot spring water has been used in the fields of medical treatment of chronic diseases, improvement of disability function and rehabilitation medicine by the pharmacotherapy and auxiliary treatment of surgical treatment from the past. It is used for recreation and rest for health maintenance and promotion. The medical effects of hot springs are considered in terms of physics, chemistry, and comprehensive biocontrol. Chemistry is the main efficacy of hot springs and plays an important role on blood vessels and skin. It has been reported that dissolved substances in hot spring water are absorbed through the skin along with physical thermal action and that these components can be absorbed through the skin when bathing in hot spring water containing a gas component. Li, Sr, Fe, Mn , And Zn are absorbed through the skin and are known to have antiviral, antibacterial, anti-inflammatory and wound healing functions in some types of skin diseases. It is known that the use of hot spring water and the comprehensive biocontrol of the natural environment and climate of hot springs normalize the autonomic, endocrine, and immune system dysfunction caused by daily life.

The hot spring water can be used to treat atopic dermatitis including dry skin, skin pruritus, skin bacterial infection, dermatitis dermatitis, psoriasis, lupus, acne, acne, contact dermatitis, chronic skin ulcer, round hair loss, Its effects have been reported in various skin diseases such as common sarcoma, plantar foot pediculosis, fat necrosis, scleroderma, vitiligo, pigmented urticaria. In the indications according to the nature of the hot spring proposed by the Japan Environment Agency, hot springs containing mineral salts such as chloride, hydrogencarbonate, and sulfate, and sulfur compounds such as sulfur, sulfuric acid, and radioactive fluids are adapted to chronic skin diseases.

The impact of these spas on the body

First,

The temperature at which you do not feel hot and cold in bathing is called dead temperature. Bathing at these temperatures is a temperature that gives little change in pulse, blood pressure, respiration, and metabolism, and it has the most genuine effect on the human body. The temperature of people in Korea is 36 ℃ (35.5 ℃ ~ 36.5 ℃) and the people in Europe are 1 ℃ ~ 2 ℃ lower than 34 ℃ ~ 35 ℃. When the temperature is higher than this, the metabolism, blood pressure, and pulse change when the temperature is higher or lower. Especially, when the temperature is higher than 40 ℃, which is preferred by the people of Korea, the rise occurs. It is generally said that when the temperature is raised by about 1 ° C and the body temperature is increased by 1 ° C, the heart rate is increased by about 20 times per minute when the body is heated for 10 to 15 minutes. The direct action of the heat causes the temperature of the warmed body part to rise, thereby increasing the size of the legs and leading to the expansion of the capillaries and the small arteries. Reflex vasodilation also occurs through autonomic nerves. The skin is enlarged by warm bathing but reflexes the internal blood vessels to shrink. So bathing right after meals is not good. The medical use temperature of hot spring water in hot spring bath should be considered based on the dead temperature.

Second, physical effects

Hydrostatic pressure

When the whole body is immersed in water, the chest is compressed by 1 ~ 3.6cm and the wrist is reduced by 2.5 ~ 6.5cm under hydrostatic pressure. Therefore, the resistance increases in the pulmonary circulation. The reason why half-bathing is recommended for patients with heart failure is to lessen the effects of hydrostatic pressure and lighten the burden on the heart.

Buoyancy

The specific gravity of the human body is 1,306 for 1,000 pieces of water. When you enter the water, the body weight is reduced to 9 in 1 by buoyancy, and it is very light to move the body. Therefore, it helps a lot of exercise exercises such as a paralyzed patient's exercise.

Third, the chemical effects

Hot springs contain many chemical components, and they play a medically important role.

For example, the drinking of bamboo cloth is good for gastrointestinal diseases, and the sulfur spring is good for circulatory cavities such as arteriosclerosis and aftereffects after stroke because it enlarges blood vessels. In addition, ingredients such as salt spring, carbonate spring, alkaline cloth, sulfur spring are good for skin diseases. There are many hot springs that show the effect of the contained ingredient itself. If it is a hot spring, the components (ions, gaseous substances) contained in it are adhered to and absorbed in the skin, causing an active chemical action at the skin end. Iron (Fe), copper (Cu), manganese (Mn), zinc (Zn) and cobalt (Co), which are trace elements contained in hot spring water, are also contained in human body and are essential components for high animals. Has been treated as an inorganic batimin, and has been functioning to absorb it into the body by hot spring bathing and drinking. This is different from ordinary water without ingredients. The hot spring therapy using nature in the hot spring area is not only the effect of the hot spring therapy but also the liberation from the daily life and stress and the environmental change (sunshine, ultraviolet ray, Etc.) is performed, and the bearing ability of the living body is further increased. Improvement of the constitution of children with weakness, health promotion of adults in the world is applying the hot spring. The environment and climate factors of the hot springs are also utilized here, and the preventive medical use of hot springs is never negligible. Especially in the recent urban life, there are many stimuli that increase the elements that hurt the mind and body and decrease the body 's defense ability. It is natural that such relaxation and rest need to be appropriate for daily stress and overwork. Hot springs can play a major role in this purpose by enhancing metabolism, improving circulation, promoting detoxification function, and regulating endocrine and autonomic functions, and can be expected to have a great effect on the prevention of disease .

The characteristic of hot spring water is that it contains various chemical components. In addition, hot springs are generally located in a fresh environment that is more polluted than the city, with excellent natural landscapes such as sea, mountains and plateau. The hot spring treatment normalizes the balance of body and mind that is disturbed by the good environment, the freedom to leave work and the sense of openness as well as the effect of hot spring bathing. Walking in the beach, mountains, and forests is not only powerful but also effective in relieving stress. When bathing, the hot spring ingredients are absorbed not only through the skin but also through the skin, but their absorption is so small that they do not yet know much about how they affect the human body.

The biggest feature of hot spring bathing is the thermal effect. Although the body is warmed by the bath of the family, not the hot spring water, the hot spring bath has the advantage of being warm as well as warmth after hot spring bathing. This is because the hot spring ingredients make the skin circulation vigorous, so that even after bathing, the ingredients form a film on the surface of the skin to prevent heat radiation. Appropriate temperature also improves circulation and lowers high blood pressure. When bathing, the weight is lighter due to buoyancy, so that the muscles are relaxed and the pain and stiffness of the muscles and joints are reduced, which is also effective for joint exercises and gait training.

The pH of the seawater hot spring water at Yonggung Hot Spring, located in Hwasungmodo, Samsan-myeon, which is used in the present invention, is about 7.8 weakly alkaline. The discharge water temperature of the hot spring water in Seokmodo hot spring region is 60 ~ 70 ℃ and the electric conductivity is 60,200 ~ 84,300 μS / cm, which is relatively high and implies that the Seomdo hot spring water is mixed with seawater. The chemical composition of seomondong hot spring water is Na-HCO ₃ , Na-Cl, Na-SO ₄ , Ca-HCO ₃ , Ca-Cl, Na-CO ₃ , Ca-SO ₄ and Mg-HCO ₃ .

It is also known that Li, Sr, Fe, Mn and F among trace elements are detected more prominently than any hot springs in Korea. These trace elements are known to have antiviral, antibacterial, anti-inflammatory and wound healing functions in skin diseases.

However, since seawater springs contain many salts, they are inadequate for application as a functional skin remedy. It is required to develop and manufacture active water using a decontamination technique which removes such salts as much as possible to reduce irritation to skin and to contain minor components that act as antiviral, antibacterial, anti-inflammatory and wound healing.

There are cosmetics that can penetrate your skin smoothly into your skin, while others do not. Highly concentrated ampoules, essences, and serums have a relatively high absorption capacity, but whipped cream products have a relatively low skin absorption function because they are responsible for protecting and moisturizing the skin. Basically, the difference in penetration of cosmetics depends on product formulation, molecular weight, pH, cosmetic base (moisture, oil) and technical problems. There is a difference in the depth to be absorbed according to the intended use and the manufacturing principle of the cosmetic as if the water component is absorbed to the epidermis, the whitening component to the base layer, and the elasticity enhancing component to the dermal layer. In order to demonstrate the efficacy of the ingredients, it is essential to understand the principle that the active ingredient is absorbed into the skin and to develop a delivery system that delivers the ingredient safely and promptly. Without this process, it is difficult to expect the active ingredient to function properly.

In order to exert the desired effect of the cosmetics applied to the skin, the patterns and the degree of absorption in each layer of the skin is a measure of the efficacy of the cosmetics. The stratum corneum, which is the outermost layer of the skin, consists of 10 to 20 layers of dead cells, which acts as a barrier to prevent moisture from evaporating in the body and preventing foreign matter from penetrating into the skin. Lipids (keratin proteins, fibrous proteins, ceramides, and neutral lipids) that act as cements between stratum corneum are present in the form of hydrophobic barriers. The dermis contains more than 90% collagen and elastin and is the basis for judging skin condition. In order for cosmetic efficacy to be absorbed into the epidermal blood vessels from the skin surface, it first passes through the epidermal layer, diffuses into the dermis layer, penetrates the capillary wall through the capillary wall, or through the accessory organ from the epidermis to the dermis I have to go. In other words, the most important factor in absorbing these active ingredients of the skin is the stratum corneum. The stratum corneum has the property of a skin barrier because it makes a lamellar structure with hydrophilic and lipophilic properties. How to loosen the hard, layered lipid bilayers and penetrate the active ingredients into the skin is the key to maximizing the desired skin effect.

Percutaneous transfusion is a typical pathway where most of the active ingredients are absorbed into the skin. It passes through the keratinocyte filled with proteins passing through the hydrophilic region and passes through the lipophilic lipophilic region. It is absorbed in the intercellular lipid existing between the keratinocyte and the cell. The active ingredient penetrates and is initially absorbed by sweat glands, Materials of high molecular weight that can not directly penetrate the stratum corneum through the organs such as hair follicles and sebaceous glands are absorbed very quickly by the diffuser. The principle of skin absorption of the active ingredient occurs by 'passive diffusion' irrespective of the various pathways penetrating the skin. Passive diffusion is the driving force of absorption, the difference between the amount of active ingredient applied to the skin and the concentration of the ingredient. If you mix deep espresso with water, it spreads and becomes Americano. In skin, passive diffusion by this concentration difference is possible, and when you apply the substance necessary for skin, it spreads inwards because it has many outside and few inside.

Up to now, it has been reported that transdermal permeability increases as the size (molecular weight) of the component decreases. However, studies have been made to increase the mobility of nanotechnology and fluid materials to enhance absorption. Even if the size of the effective ingredient is easy to absorb, it will be useless if it is oxidized in the process of absorption or destroyed by light or heat. In other words, it is an important question how safe the active ingredient is absorbed and transmitted through the stratum corneum to the dermis.

The possibility of delivering the active ingredient through the stratum corneum through the intercellular route between the skin cells is only about 0.3%, and it is even more difficult due to the keratinization action of the skin cells and the inherent characteristics of the cells. It is important to develop transdermal absorption accelerators that act quickly on skin with skin-affinity and high absorption rate as well as nanotechnology.

On the other hand, the technique using mechanical vapor compression (MVR) was developed as a domestic patent registration No. 10-1273247, but it has not been used as a skin moisturizing agent and transdermal absorption promoter by using sea water hot spring water as mineral active water.

The present invention is intended to solve this problem. However, since the sea water hot spring water contains a large amount of salt, it is not suitable for use as a functional skin improving agent. However, in the present invention, It is an object of the present invention to provide a skin moisturizing agent and a transdermal absorption promoter using mineral active water by confirming the ease of skin moisturization and transdermal absorption promotion so as to reduce irritation to skin and antiviral, antibacterial, antiinflammatory and wound healing .

The present invention also confirms that the mineral active water obtained from the seawater hot spring water of the Yonggung Hot Spring, which is absorbed quickly by percutaneous absorption and has a moisturizing effect, has a quick absorption and moisturizing effect on the transdermal system, and the mineral active water, which is a mineral- Decomposition of salt in seawater hot spring using MVR is rich in minerals of hot spring water. In particular, it contains Li and Sr Zn as much as possible. It increases the reproductive ability through transdermal absorption, And to provide a skin moisturizing agent and a transdermal absorption promoter using mineral active water that can be given.

The present invention provides a skin moisturizing agent containing minerals active water obtained by mechanically depressing the seawater hot spring water of Seokmodo dragon hot spring of Kanghwa-gun, Gyeonggi-gun, and obtaining the obtained mineral active water.

The present invention also provides a transdermal absorption enhancer comprising mineral water obtained by mechanically depressing seawater hot spring water in Seokmodo dragon hot spring of Kanghwa-gun, Ganghwa-gun, and the obtained mineral active water.

The present invention is based on the finding that the mineral active water obtained by distillation in the seawater hot spring of Seokmodo Yonggung Hot Spring, Kangwon-gun, Kangwon-do, has a high content of mineral components and the minerals contained therein reduce irritation to the skin and provide antiviral, antibacterial, anti- Therefore, the skin moisturizing agent and transdermal absorption promoter using the same are easy to moisturize the skin and promote transdermal absorption.

The present invention confirms that the mineral active water obtained by distillation in the seawater hot spring water of the Yonggung Hot Springs has a rapid absorption and transdermal absorption in the transdermal system and the mineral active water is converted into a salt of the seawater hot spring by the mechanical vapor compression method (MVR) When decontamination is used as a skin moisturizer and transdermal absorption enhancer using minerals active water obtained by enrichment of mineral springs, it is confirmed that Li, Sr, and Zn are contained as much as possible. The transdermal absorption can increase the reproductive ability and give a variety of physiological activities.

BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a schematic view showing the preparation of mineral active water used in the present invention,
2 is a graph showing skin permeability characteristics of the present invention,
FIG. 3 is a graph showing the skin moisture content characteristic curve of the present invention,
FIG. 4 is a graph showing the characteristics of the transdermal skin moisture loss according to the present invention,
FIG. 5 is a graph showing the skin moisture retention characteristic after skin barrier damage according to the present invention,
FIG. 6 is a graph showing the characteristics of transdermal fat loss after skin barrier damage according to the present invention,
FIG. 7 is a graph showing a normal skin moisturizing effect graph of the present invention,
FIG. 8 is a graph showing a normal skin transdermal water loss amount characteristic graph of the present invention,
FIG. 9 is a graph showing the moisture content after skin barrier damage according to the present invention,
FIG. 10 is a graph showing a characteristic curve of transdermal water loss after skin barrier damage according to the present invention,
FIG. 11 is a graph showing skin moisture retention characteristics of normal skin and skin barrier damaged skin of the present invention,
FIG. 12 is a graph showing the transdermal water loss loss characteristics of normal skin and skin barrier damaged skin according to the present invention,
FIG.
FIG. 14 is a photograph of the skin moisturizing agent containing the 10% mineral active water of the present invention at the time of 1 hour after using the state of FIG. 13,
Figure 15 is a photograph of skin barrier damaged skin,
FIG. 16 is a photograph of the skin moisturizing agent containing the 10% mineral active water of the present invention at the time of one hour after using the state of FIG. 15.

1 is a schematic view of a mechanical vapor recompression (MVR) of the present invention. The mechanical vapor recompression (MVR) of the present invention comprises a boiler 2 having an electric heater 3 or gas as a heat source, a seawater hot water tank 1 for receiving and storing seawater hot spring water, A condenser 4 installed in a connection pipe provided above the seawater hot water tank 1 to discharge steam heated at the upper end of the seawater hot water tank 1 and a condenser 4 for condensing the remaining steam, A steam compressor 6 for generating a high-pressure high-temperature steam in a recompression state and feeding it back to the seawater hot water tank 1, and a condenser 6 for returning the steam to the mineral water- So that the sensible heat is recovered and recycled to the seawater hot water tank 1.

The mineral active water developed by the present invention was developed by Yonggung Hot Spring, which is a seawater hot spring of Yonggung Hot Spring, which is located in the Meegeum-ri, Samseong-myeon, Gwangmodo, Kangwon-do. The mineral activated water is manufactured by Mechanical Vapor Recompression (MVR) (MVR) system used in the present invention is a system in which a large volume of low-pressure steam that has been discarded in an industrial plant or the like is converted into an advanced energy by the steam compressor 6, It can be applied to various plants as well as simple seawater desalination and wastewater treatment to recover a large amount of energy. 1, a seawater hot spring water tank 1 is filled with a seawater hot water tank 1, a hole is formed in the upper end of the seawater hot water tank 1 to connect the connecting pipe, The mineral active water, which is distilled water condensed through the condenser 4 by incorporating the long condenser 4, is connected to the mineral active water tank 5 in which the mineral water is stored. When electricity is supplied to the electric heater (3) in use, when heat is generated and the seawater hot water in the seawater hot water tank (1) is boiled, the temperature rises and boiling starts at the boiling point temperature, and steam is generated. Here, the range where the temperature rises is called the sensible heat region, and the region where the steam is generated at a certain temperature is called the latent heat region. When the generated water vapor passes through the condenser (4) of the connection pipe and cools down with cold water, the condensed water becomes mineral active water and flows to the mineral active water tank (5). Here, cooling the steam is like abandoning the enormous energy of the generated steam, and how to recycle this energy is the key to lowering the cost of condensate production. The amount of electricity or gas energy required to boil the raw water per unit flow rate is expressed as the amount of steam of 100 (° C) having the same energy and is referred to as the input steam amount, and is an index indicating how efficiently the energy is used. The ratio of the obtained steam to the steam is defined as a steam economy index or a gain ratio (GR). This is the energy required to pumping heat from a heat pump unit, and how much heat is used to obtain it. This is equivalent to the Coefficient of Performance (COP), and the single utility evaporation desalination unit is approximately SF ≡ GR ≡COP = 0.8 or so.

The heated steam from the seawater hot water tank 1 originally has a lot of energy (latent heat of vaporization) but is condensed through the condenser 4 and is of low quality for reuse. This low quality steam is recycled as latent heat and efficiently compressed by a steam compressor 6 to increase the quality (temperature, pressure) of the energy by high-temperature and high-pressure steam, and then to the seawater hot water tank 1 The seawater hot water supplied by feedback is continuously heated and reused as a heat source for vaporizing. The reciprocating type and the screw type are principally mixed with the steam and the oil for preventing the mechanical friction, and the steam ejector (steam type ejector, the present invention requires that the energy efficiency and the effective trace amount of the seawater hot spring water are optimally preserved and the amount of the salt (s) Thereby making it possible to prepare a decontaminated mineral active water composition.

Since the hot spring water used in the present invention contains a large amount of mineral components, the present invention is used as raw water, and the components of the seawater hot spring water and domestic hot spring water are shown in Table 1 below.

(Unit: ppm)

Contents Dragon Chulsan Onyang meteor Suanbang Bugok Haeundae ℃ 70.0 40 50 50 45 60 60. pH 7.84 8.76 9.15 8.89 8.30 9.16 7.70 K 93.8 1.2 1.9 1.5 2.4 2.3 33.0 Na 4,650 42 60 48 75 95 953 Ca 3,120 2.6 1.4 1.8 12.0 1.9 511 Mg 254 0.2 0.1 0.1 0.2 0.2 7.3 Fe 0.70 tr tr 0.0 tr 0.0 tr Mn 2.05 - - - - - tr Li 9.1 0.1 0.1 0.1 0.1 0.1 0.2 Sr 75.0 tr tr 0.0 tr 0.1 7.6 Cu 0.07 - - - - - - Zn 1.68 - - - - - - CI 13,200 13 39 20 19 13 226 F 0.29 6.0 2.2 5.5 7.3 3.0 1.5 HCO ₃ 48.8 67.0 61.0 76.0 163.0 29.00 25.00 CO ₂ 13.21 - - - - - tr Si 13.21 25.00 32.00 28.00 50.00 63.00 51.00

Table 2 compares the rare mineral components of seawater hot springs, general seawater and deep seawater used in the present invention.

ppm General sea water Deep water Sea water hot spring water Fe 0.00003 0.023 0.7 Zn 0.00035 0.68 1.68 Mn 0.00002 0.011 2.05 Sr 0.0001 0.003 75 Li 0.001 0.001 9.1

Table 3 shows the results of preparation of the mineral active water according to the mechanical press substrate compression conditions of the present invention.

Test conditions for manufacturing:

- Heat input (seawater hot water tank (1)): 100 110 ^o C

- Steam compressor (2) Output high pressure steam: 100 120 ^o C

- Condensing time: 6 48 hours

Comparison conditions:

- Heat input (seawater hot water tank (1)): 100 ^o C

- Steam Compressor (2) Output High Pressure Steam: 100 ^o C (A), 105 ^o C (B), 110 ^o C (C)

- Condensation time (3): 24 hours

ingredient Detected amount (ppm) Sea water bath A (100) B (105) C (110) Na 4,650 16.5 7.4 3.4 K 93.8 4.2 1.6 1.0 Ca 3,120 103 67 52 Mg 254 48 14 8 Fe 0.7 0.3 0.1 0.007 Zn 1.68 0.07 0.07 0.002 Mn 2.05 0.09 0.001 - Sr 75 56 54 12 Si 13.2 3.1 1.0 0.01 Li 9.1 5.2 5.2 1.1 Cl 12,700 43 27 11

A, B, C;

Table 4 shows the comparison between the mineral active water prepared in the present invention and the worldwide mineral active water.

(ppm) Lourdes
(F) Nordenau
(dock) Evian
(S) Perrier
(F) Samdasoo
Lava seawater
(Jeju)
Mineral active water
Ca 44.5 54.3 78 149 2.6 393 67 Mg 3.6 12.0 24 7 3.2 1234 14 Na 3.6 3.8 5 12 5.7 10019 7.4 K 0.8 1.2 One 1.4 2.1 383 1.6 Ca / Mg 12.4 4.5 3.3 21.3 0.8 0.3 4.8

In case of world famous water, the concentration of Ca / Mg is relatively high.

Skin permeability experiment

Hairless mouse (18-20 g, male) The permeation rate of mineral active water through the skin was measured using a Franz diffusion cell. The hairless mouse was sacrificed by cervical dislocation. After removing the skin from the back area with a size of about 3 cm × 3 cm, the subcutaneous fat and tissues were carefully removed so as not to damage the skin. The skin was fixed between the donor and receptor phases so that the keratin portion was directed to the donor phase. The skin area in contact with the receptor phase was 2.0 cm2. For the receptor phase, 12 mL of benzylalcohol: PBS: PEG400 = 3: 8: 4 (v / v / v) was used and stirring was continued at 600 rpm while maintaining the temperature at 37 ± 0.5 ^° C. 500 μL of each test solution was added to the skin surface of the donor phase, 1.0 mL of the receptor phase was collected for 12 hours at regular intervals, and immediately supplemented with the same amount of fresh media.

Immediately after collecting the samples for 12 hours in the skin permeation experiment, the remnants on the skin surface were washed out with methanol. Cellophane adhesive tape (CuDerm corporation, Dallas, USA) was applied 20 times to the stratum corneum and removed to remove the stratum corneum. The amount of mineral active water remaining in the dermis layer was quantitated by HPLC using a filter (0.22 μm) after homogenizing with 2 mL of methanol, taking the skin area of 2.0 cm ² in contact with the mineral active water, Evaluation of Skin Moisture of Active Water)

Hydrogel formulations for skin moisturisation evaluation and in vivo test methods

The reason for using the hydrogel evaluation is that the hydrogel is swollen when it comes into contact with water and is used as a polymer capable of containing water in its structure or as a hydrophilic polymer cross-linked by a bonding force such as ionic interaction, hydrogen bonding, to be. These polymers do not dissolve in water when contacted with water but retain their three-dimensional structure, so they can absorb much water and the dried hydrogel can absorb about 20 times its own weight of water. Since it has the ability to regulate drug permeability, it is highly utilizable as a drug delivery body and forms a hydrophilic bridge with the skin, thereby hydrating the skin and promoting absorption of the drug through the skin. xanthangum is a thickening agent widely used in cosmetics because it has no viscosity drop due to pH and is stable even in the range of pH 2-13. Carbopol 940 is a polyacrylate with a molecular weight of 1 × 10 6, which forms an acidic colloid solution when dispersed in water. When neutralized, it forms a viscous gel. It is non-toxic and non-irritating when applied to skin. It is used not only for the sustained action of the hydrogel and the drug but also for the liquid or semi-solid preparation. Thus, various additives such as 1,3-butylenglycol, glyceline, and benzylalchol were added to hydrogel to prepare skin application formulations containing mineral active water of xanthangum and carbopol mixed gel as shown in Table 5 below.

To evaluate the moisturizing agent containing mineral active water, a moisturizer containing purified water was used as a control group and the experimental group was prepared using a moisturizer containing mineral active water as follows. As shown in Table 5, the formulations to be used in the experiment are seven types of formulations in which mineral hydrolyzate is added to the basic hydrogel, basic moisturizer type, and basic moisturizer type with mineral broom water. Carbopol gels were prepared by mixing carbopolgel and xantangumgel gels to improve the film formation. To improve the moisturizing effect, various additives such as 1.3BG (1,3-butylenglycol), glyceline and benzyl alchol were used. Mineral active water B was added at 10, 20, and 30%, respectively. The hydrogel was prepared by dissolving 0.5 g of carbopol 940 and xanthan gum (incremental agent) in water, adding 1 g of triethanolamine at room temperature, stirring the mixture, and slowly adding TEA (tri ethanolamine) . To prepare the moist hydrogel, mineral active water and various additives, 1,3 - butylenglycol, glyceline and benzylalchol were added to the mixed gel, followed by agitation at high speed while slowly adding TEA, followed by refrigerated storage.

Subjects were selected from 20 healthy 20 female college students who had no previous history of skin disease. Subjects were asked to cleanse with a neutral detergent for 30 minutes or more under an environment of 25 ± 2 ^° C and a relative humidity of 40-60% After stabilizing and adapting to the measurement site, the forearm of each arm of the subject was marked on the left and right forehead by a circle approximately 3 cm in width and 3 cm in length. Tapestripping was performed 20 times using Scotchtape on the left forearm, And skin barrier damage. Before the application of the sample without applying any treatment to the right forearm, we measured the moisturizing condition and then performed the experiment. The basic hydrogel formulation used in this experiment and the hydrogel formulation with the moisturizing agent were applied to the skin, respectively, and the skin moisture state was measured non-invasively at intervals of 10 minutes, 30 minutes, and 60 minutes in the in vivo state (CourageandKhazaka, Germany), which is a device for measuring the capacitance of a probe, is used to make a contact with the surface of the measurement site and then lightly pressed to display the measurement value in an arbitrary unit (AU) I wiped the probe surface with a soft tissue. In addition, using a Tewarmeter TM210 (CourageandKhazaka, Germany), which is a device for comparing transepidermal water loss (TEWL), the probe is held in contact with the measurement site vertically for more than 15 seconds, g / ㎡ h) was measured. The corneometer and tewarmeter measurements were taken 5 times each time and mean values were obtained and are shown in Table 5. Moisturizing effect of normal skin was measured in the right forearm, and barrier skin damage was measured in the left forearm.

Hydrogel formulations to which mineral active water B is added

A-1: basic hydrogel, A-2: Mineral active water 10%

A-3: Mineral active water 20%, A-4: Mineral active water 30%

B-1: Basic moisturizing hydrogel, B-2: Mineral active water 10% Moisturizing,

B-3: Mineral active water 20% moisturizing

Evaluation of skin moisturization through hydrogel

To determine the usefulness of the hydrogel formulation as a moisturizing agent, the basic aqueous gel formulation (A-1) was used as a control, and the mineral active water B was added to the aqueous solution containing 10%, 20%, 30% -4) were applied to the subject's skin. The changes in the skin moisture content and the amount of TEWL were measured at intervals of 10 minutes, 30 minutes, and 60 minutes, respectively, as shown in FIGS. 3 and 4, As shown in Fig.

○ Hydrogel formulation of normal skin

As a result of measuring the skin moisture content of each formulation after 10 minutes of application of the respective formulations to the normal skin, the skin to which the basic hydrogel formulation was applied increased from a minimum of 26 to a maximum of 48 before the application and a 10% To a maximum of 33. The hydrogel formulation showed the greatest increase in the mineral active water B 20% formulation from 28 to 49 after 10 minutes of application. On the other hand, the mineral active water B 30% formulation increased from the lowest 24 to the maximum 32 after 10 minutes of application, indicating that formulations with excessive deep sea water content lowered the skin moisture content.

The results of the measurement of skin water loss showed that the basic hydrogel formulation increased from 6.5 to 11 after 10 minutes of application and that the mineral active water B 10% formulation increased from 5.6 to 11.5 after 10 minutes of application, B 20% formulations increased from a minimum of 6.8 to a maximum of 12.7 after 10 minutes of application and the mineral active water B 30% formulations showed an increase from a minimum of 5.7 to a maximum of 10.4 after 10 minutes of application. That is, the basic hydrogel formulations were increased by an average of 1.5, the formulations containing 10% of the mineral active water B were increased by an average of 2.5 from the pre-application, the mineral active water B 20% formulations were increased by an average 2.3 compared to before application, The number of B 30% formulations increased by an average of 2 compared to that before application, and there was a difference in water loss according to the formulation, but the amount of water loss after application of all formulations increased compared to the amount of water loss before application. This means that not only the skin moisture content but also the evaporation amount is increased in the case of addition of deep sea water.

○ Hydrogel formulation of skin after barrier damage

As a result of measuring the moisture content of each formulation after application of the respective formulations to the barrier damaged skin, the moisture content of the skin applied with the basic hydrogel formulation increased from 25 to 44 after 10 minutes from the application, The number B 10% formulation increased from the lowest 31 to the maximum 46 after 10 minutes of application. The mineral active water B 20% formulation showed the highest moisture content among the coating formulations after 10 minutes from the application to the lowest value from 32 to 57 after the application, and the mineral active water B 30% formulation showed the lowest value from 27 to 40 after 10 minutes of application Respectively. The average value of 10 minutes after application of the water wetting amount showed an average of 35 in the case of the basic hydrogel formulation, the mineral active water B 10% formulations averaged 37, the mineral active water B 20% formulations averaged 38, the mineral active water B The 30% formulation was increased to an average of 32. As a result of the measurement, it was found that the formulation with mineral active water B increased the moisture content more than the basic hydrogel formulation, and the mineral active water B 20% formulation was the highest Respectively.

In the case of skin water loss, the basic hydrogel formulation increased from a minimum of 8.2 to a maximum of 9.7 after 10 minutes of application, and the mineral active water B 10% formulation showed an increase from a minimum of 7.3 to a maximum of 10.6 after 10 minutes of application. Mineral active water B 20% formulation showed the lowest values from 8.3 to 14 after 10 minutes of application, and mineral active water B 30% increased from the lowest value of 8.9 to 12.6 after 10 minutes of application. The average value of water loss was increased to 8.7, 10% for mineral hydrolytic form, 8.9 for basic hydrogel formulation, 9.7 for MA_Water 20% formulation after 10 minutes of application, and 30% The formulation increased to 10.2 after 10 minutes of application, and the barrier damage skin showed increased water loss after 10 minutes of application than before application as well as normal skin. As seen from the normal skin, the addition of mineral active agent B It was observed that the water evaporation was high in the formulation.

○ Evaluation of moisturizing hydrogel formulation

In the evaluation of the moisturizing hydrogel formulation, the moisturizing effect of the hydrogel formulation containing 10% and 20% of the mineral active water B, which is considered to be effective in the skin moisture retention ability,

The moisture content of the normal skin was measured by the moisture content of the normal skin. The basic moisturizer type showed an increase value from the lowest 48 to the maximum 73 after 10 minutes of application, and increased to 29 before the average application and 60 after 10 minutes of application. Mineral active water B 10% Moisturizing agent showed a rise value from 52 to 77 after 10 minutes of application and increased from 27 before the average application to 64 after 10 minutes of application. Mineral active water B 20% Moisturizing agent type increased from 46 to 74 after 10 minutes from application. It increased from 27 before application to 10 after 59 minutes after application. In all moisturizer types, all subjects exhibited increased moisture content, which was relatively higher than that of the basic hydrogel formulation, and it can be interpreted that synergistic effect of mineral active water on skin moisturizing ability.

In the case of skin moisture loss, the basic moisturizer type showed a minimum of 3.8 and a maximum of 7.8 after 10 minutes of application, and decreased from 6.4 before the average application to 5.5 after 10 minutes of application. Mineral active water B 10% moisturizer type showed a minimum of 3.5 to maximum 8.7 after 10 minutes of application and decreased by an average of 1 from 5.5 before the average application to 5.5 after 10 minutes of application. Mineral active water B 20% moisturizer type showed a slight increase from 6.3 before the average application to 6.5 after 10 minutes from the application, after 10 minutes from the application. The amount of moisture loss of the skin applied with all the moisturizing formulations showed a tendency to decrease differently from the case of the hydrogel type application, and the lipid component of the moisturizing agent appeared to act as a membrane to prevent water evaporation.

○ Measurement of moisture content of skin after barrier damage

The moisture content of the skin after barrier impairment was increased from 48 to 76 after 10 minutes of application. Mineral active water B 10% moisturizer type showed the lowest moisture content of 59 to 72 after 10 minutes of application Lt; / RTI > Mineral active water B 20% moisturizer type showed the highest rising value from 54 to 82 after 10 minutes of application. The average moisturizing agent type increased from 28 before application to 68 after application 10 minutes after application of skin moisture content. The mineral active component B 10% formulation was applied at 27 before application 10 min. After 64 min., Mineral active water B 20% formulations showed 26 to 10 min after application and 67, respectively. Therefore, the formulation containing mineral active water B showed higher moisture content than the basic moisturizer type there was. Mineral active water B 20% Moisturizing agent showed the highest moisture content after 10 minutes of application, but the variation among subjects was relatively large. On the other hand, the mineral active water B 10% humectant type showed a gradual decrease It can be said that the amount of water absorption can be relatively better.

In the case of moisture evaporation, the basic moisturizer type showed a minimum of 4.5 to a maximum of 8.2 after 10 minutes of application and decreased from 6.8 before the average application to 5.9 after 10 minutes of application. Mineral active water B 10% moisturizer type showed a minimum of 4.8 to maximum 15 The average value increased from 6.4 before the average application to 7.2 after 10 minutes of application. Mineral active water B 20% moisturizer type showed the lowest value from 4.3 to the highest 14.4 after 10 minutes from the application, and the average value increased from 6.4 before the application to 7.8 after 10 minutes from the application.

In vivo skin moisturization evaluation

○ Effect of Mineral Active Water on Skin Moisture Retention

In order to observe the effect of mineral active water on the skin barrier, the experiment was conducted on subjects. As a result, the basic formulation showed lower moisture content than the formulated with mineral active water. After 60 minutes, the basic hydrogel formulation showed 4%, mineral active water B 10%, mineral active water B 20%, mineral active water 8%, mineral active water 10% The number of B 30% formulation was -6%, and all formulations showed an increase in the mean value of the moisture content of the skin after barrier damage compared to the normal skin, and the skin barrier recovery rate was measured by TEWL measurement In the formulation with mineral active water B, the barrier recovery rate was higher than that of the basic hydrogel formulation. The TEWL was lower in the hydrogel than in the basic hydrogel, although the difference was dependent on the change of the concentration of the naringenic activator B. In the case of the barrier damaged skin, the basic hydrogel formulation showed 11% Mineral active water B 1% formulated, mineral active B 20% formulated 0% and MA_Water 30% formulated 1%, although the formulation with minerals active B is different depending on the concentration of MA_Water, It was found that the skin retention ability was better than the gel formulation, and it was found that the skin after the skin barrier damage was moisturized more than the normal skin. As a result of measuring the change of water content in the stratum corneum with a basic hydrogel moisturizer type and a moisturizer type containing mineral active water B, the average value of the water content of the subject in the skin after the normal condition and the barrier damage was 10 minutes Although all the formulations showed the highest values, the tendency was to gradually decrease after 30 minutes and 60 minutes of application. However, the moisture content was not decreased even after 60 minutes from the application, and the moisturizer type with the mineral active water B And the moisture content was high. In the skin of normal condition, the basic moisturizer type showed 106% after 10 minutes of application and 85% after 60 minutes, and the mineral active type B 10% moisturizer type showed 138% after 10 minutes of application and 102% after 60 minutes, B 20% moisturizer showed 120% moisture content after 10 minutes of application and 81% moisture content after 60 minutes. On the other hand, in the skin after barrier damage, the basic moisturizer type showed 146% after 10 minutes of application and 117% after 60 minutes of application. The mineral active type B 10% moisturizer type showed 138% after 10 minutes of application and 118% after 60 minutes of application, The number of B 20% moisturizer type showed 158% after 10 minutes of application and 108% after 60 minutes. Therefore, moisturizer type with mineral active water B added to the skin after barrier impairment is better than basic moisturizer type. Mineral active water B 10% Moisturizing agent type showed no difference between normal skin and barrier skin after 10 minutes of application, but the difference between 30 minutes and 60 minutes after application was not greater than that of other formulations and water wetting ability was maintained The results showed that the water absorption rate of the mineral active water B 20% humectant type was the highest after 30 minutes from 10 minutes after the application, . Fig. 11 shows the results of normal skin corneometry and corneometry after skin barrier damage. Fig. 11 shows A-base moisturizer type, B-mineral active water B 10%, CM mineral active water B 20% basic moisturizer type, E-TS mineral active water B 10%, and F-TS mineral active water B 20%.

In other words, it was found that the formulation containing the mineral active agent B, compared to the basic moisturizing agent, exhibited good wetting ability and retention ability on the skin after the barrier damage, and the formulation containing the mineral active agent B 10% showed continuous moisture- It was found that the water content was good. TEWL showed a lower TEWL than that of the basic moisturizer type with the mineral active agent B added to the skin after normal condition and barrier damage.

The skin barrier recovery rate was 10 minutes, 30 minutes, and 60 minutes after the barrier damage. The average TEWL value of the formulations containing the mineral active agent B was 10 minutes after the application of the basic moisturizer type. , But the MA_Water 10% moisturizer type decreased continuously to -15% and -24% after 30 minutes of application 30 minutes after application. Mineral active water B 20% moisturizer type decreased by -20% after 30 minutes of application and 18% after 60 minutes. On the other hand, the basic moisturizer type showed a continuous decrease of -13% after 30 minutes of application, -19% after 30 minutes of application, and -21% after 60 minutes of application, but the barrier recovery rate was lower than that of the formulation containing mineral active water B I was able to confirm. Fig. 13 shows the results of a corneometer measurement after normal skin corneometry and skin barrier damage, showing that A-basic moisturizer type, B-mineral active water B 10%, C-mineral active water B 20% D-TS basic moisturizer type, E- B 10%, and F-TS mineral active water B 20%.

14 to 16 show that the mineral active water B has a difference in the amount of skin moisture and the amount of light skin loss according to the change in concentration, but the formulation containing the mineral active water B is more effective for moisturizing the skin than the basic moisturizer type there was

1, a seawater hot water tank 2, a boiler 3, an electric heater 4, a condenser 5, a menellal active water tank 6,

Claims (6)

A skin moisturizer containing minerally active water obtained from seawater hot spring water by obtaining seawater hot spring water of Seokmodo Yonggung hot spring of Kanghwa-gun, Gyeonggi-gun, Korea. The skin moisturizing agent according to claim 1, wherein the skin moisturizing agent comprises the composition of the following table:

3. The skin moisturizer according to claim 1 or 2, wherein the mineral active water is composed of the composition ratio shown in the following table.

A transdermal absorption enhancer comprising mineral water obtained from seawater hot spring water by obtaining seawater hot spring water of Seokmodo Yonggung hot spring of Kanghwa-gun, Gwangmok-gun, Korea. The transdermal absorption enhancer according to claim 4, wherein the skin moisturizing agent comprises the composition of the following table.

The transdermal absorption enhancer according to claim 4 or 5, wherein the mineral active water is composed of the composition ratio shown in the following table.

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