KR20150105552A - Composition comprising mixture extract of Ephedra sinica, Rheum palmatum L and Arnebia euchroma for preventing or treating obesity - Google Patents
Composition comprising mixture extract of Ephedra sinica, Rheum palmatum L and Arnebia euchroma for preventing or treating obesity Download PDFInfo
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- KR20150105552A KR20150105552A KR1020140027116A KR20140027116A KR20150105552A KR 20150105552 A KR20150105552 A KR 20150105552A KR 1020140027116 A KR1020140027116 A KR 1020140027116A KR 20140027116 A KR20140027116 A KR 20140027116A KR 20150105552 A KR20150105552 A KR 20150105552A
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- rhubarb
- obesity
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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Abstract
Description
본 발명은 마황, 대황 및 자초의 혼합 추출물을 유효성분으로 포함하는 비만의 예방 또는 치료용 조성물에 관한 것이다.
The present invention relates to a composition for preventing or treating obesity, which comprises a mixed extract of mahwang, rhubarb and grass as an active ingredient.
최근 경제성장과 생활방식의 변화에 따라 식습관에도 많은 변화가 있었다. 특히, 바쁜 현대인들의 경우 패스트푸드 등의 고열량 식이와 적은 운동량으로 인하여 체중 과다 및 비만이 증가하고 있다. 체중 과다는 체질량 지수 (BMI, 체중을 키의 제곱으로 나눈 비만 척도)가 25 이상 30 미만을 의미하며, 비만은 체질량 지수가 30 이상일 때를 의미한다.Recent changes in diet and eating habits have been accompanied by changes in economic growth and lifestyle. Especially, busy modern people are overweight and obese because of high calorie diet such as fast food and low exercise amount. Weight overweight means that the body mass index (BMI, obesity index divided by the square of body weight) is 25 or more and less than 30, and obesity means the body mass index is 30 or more.
미국 성인의 3분의 2는 체중 과다이거나 비만이며, 체중 과다는 혈압과 콜레스테롤 수치를 높여 심장 질환 등의 각종 성인병의 발병률을 증가시킨다. 비만이 여러 가지 질병에 미치는 영향은 매우 심각하여 전 세계 당뇨병 환자의 80 %, 심장질환의 21 %가 비만이 원인인 것으로 알려져 있다. 이 외에도 자궁암, 신장암, 유방암 등 각종 암 또한 비만과 직, 간접적으로 연관되어 있으며, 비만이나 과체중의 경우 수면무호흡증, 골 관절염, 담석증 등의 발병률도 정상인보다 높다 (Stein CJ, Colditz GA. The epidemic of obesity. J Clin Endocrinol Metab 2004; 89: 2522-2525. ; Kopelman PG. Obesity as a medical problem. Nature 2000 Apr 6; 404(6778): 635-43.). Two-thirds of US adults are overweight or obese, and overweight increases blood pressure and cholesterol levels, increasing the incidence of various adult diseases, including heart disease. The effects of obesity on various diseases are so severe that it is known that 80% of diabetics worldwide and 21% of heart disease are caused by obesity. In addition, various cancers such as uterine cancer, kidney cancer, and breast cancer are directly or indirectly related to obesity. Obesity and overweight also have higher rates of sleep apnea, osteoarthritis, and cholelithiasis (Stein CJ, Colditz GA. The epidemic J Clin Endocrinol Metab 2004; 89: 2522-2525; Kopelman PG, Obesity as a medical problem, Nature 2000
비만은 한 가지 원인으로 발생하는 질병이 아니라 유전적, 환경-사회적, 정신적 등 여러 가지 요인들이 복합적으로 작용하여 발생하기 때문에 어느 한 가지 방법으로 치료하기는 어렵다. 현재 비만을 치료하기 위한 방법은 식사요법, 운동요법, 행동요법 등 생활 습관을 교정하는 방법과 약물치료 및 수술적 치료로 나눌 수 있다. 약물이나 수술적 치료에 앞서 생활습관을 교정하기 위한 적극적인 노력이 선행되어야 하지만, 생활습관을 교정하는 일이 쉽지 않을 뿐 아니라 생활습관 교정만으로 감소시킬 수 있는 체중은 한계가 있다. 따라서 많은 경우에 생활습관 교정과 함께 약물치료가 필요하다.Obesity is not caused by a single cause, but by a combination of genetic, environmental, social, and mental factors. Current methods of treating obesity include diet, exercise, and behavioral therapy, as well as methods of correcting lifestyle, drug therapy, and surgical treatment. Although active efforts should be made to correct lifestyle prior to medication or surgical treatment, it is not easy to correct lifestyle habits, and there is a limit to the weight that can be reduced by lifestyle correction alone. Therefore, in many cases, lifestyle correction and medication are necessary.
이러한 비만의 약물 치료를 위해 매년 많은 항비만 제제들이 개발되고 있지만 현재 사용 가능한 비만 치료 약물은 많지 않으며, 대부분 소화나 식욕을 억제시키는 제제에 국한되어 있다. 소화나 식욕을 조절하는 제제의 경우, 습관성 때문에 향정신성 약물로 분류되며, 소화억제제는 설사, 변비 등의 부작용을 나타낸다. 2010년까지 미국 FDA가 장기사용을 승인한 대표적 비만치료 약물은 노르에피네프린(norepinephrine)과, 세로토닌(serotonin)의 재흡수를 억제하는 작용을 가진 시부트라민(sibutramine; Reductil), 췌장 및 소화기계에서 분비되는 리파제(lipase)를 억제하여 효과를 나타내는 오르리스타트(orlistat; Xenical)가 있었다 (Yanovski SZ, Yanovski JA. Obesity. N Engl J Med 2002; 346: 591-602.).Although many anti-obesity agents are being developed every year for the treatment of obesity, there are not many obesity agents available at present, and most of them are limited to digestive or appetite-suppressing agents. In the case of digestive or appetite control agents, they are classified as psychotropic drugs because of habit, and digestion inhibitors show side effects such as diarrhea and constipation. Typical obesity treatment drugs approved for long-term use by the US FDA until 2010 include norepinephrine and sibutramine (Reductil), a substance that is secreted by the pancreas and digestive system, which has the function of suppressing reabsorption of serotonin There was orlistat (Xenical), which has the effect of inhibiting lipase (Yanovski SZ, Yanovski JA, Obesity, N Engl J Med 2002; 346: 591-602).
그러나 시부트라민은 혈압상승, 불면증, 구강건조, 어지러움 등의 부작용이 흔하고, 심근경색과 뇌졸중 등 심혈관계 증상이 나타날 위험이 있어 2010년 10월 미국 및 국내에서 퇴출되었다. 또한 오르리스타트는 설사, 지방변, 분실금 등의 부작용이 흔하고 한국인과 같이 서양인에 비해 지방 섭취가 적은 경우에는 약물의 효과가 뚜렷하지 않아 사용이 제한되고 있다 (김상만. Orlistat에 대한 연구. 대한비만학회지 1998; 7(4): 287-92.). However, sibutramine has been withdrawn in the US and Korea in October 2010 due to the risk of cardiovascular events such as myocardial infarction and stroke, which are common with side effects such as elevated blood pressure, insomnia, dry mouth and dizziness. In addition, Orristat has been reported to have side effects such as diarrhea, fatty liver, loss of gold, etc. When the fat intake is lower than that of westerners like Koreans, the effect of the drug is not clear and its use is limited (Kim, Sangman. 1998; 7 (4): 287-92.).
한편, 마황(Ephedra sinica Stapf.)은 마황과의 상록관목으로, 발한해표, 선폐평천, 리수소종의 효능이 있어 풍한감모, 기관지 천식, 비염 등에 많이 응용되어 왔다.On the other hand, Ephedra sinica Stapf. Is an evergreen shrub with mahwang. It has been widely applied to haemorrhoids, bronchial asthma, and rhinitis because of its efficacy of perspiration, seaweed, and lysozyme.
대황(Rheum palmatum L)은 마디풀목 마디풀과의 여러해살이풀로 사열통장, 량혈해독, 축어통경하는 효능이 있어 실열변비, 적체복통, 혈열토뉵 등에 주로 활용되고 있다. Rheum palmatum L is a perennial herb that has been used as a dietary supplement for the treatment of acupuncture and moxibustion, as well as for the treatment of constipation, abdominal pain and hemorrhoids.
자초(Arnebia euchroma Johnst.)는 지치 또는 지초라고도 하며, 량혈, 활혈, 해독하는 효능이 있어 항염, 항과민 작용이 필요한 피부 질환에 주로 사용된다.Arnebia euchroma Johnst., Also called leeches or worms, is used mainly for skin diseases that require blood circulation, blood clotting, and deciphering, and therefore require anti-inflammatory and anti-irritant action.
그러나 현재까지, 마황, 대황 및 자초의 혼합 추출물의 항 비만 효과에 대해서는 보고된 바가 없으며, 이에 대한 연구도 전무한 상황이다.However, to date, the anti-obesity effect of mixed extracts of mahwang, rhubarb and grass has not been reported, and there is no research on this.
이에 본 발명자들은 기존의 비만 치료를 위해 개발된 약물들의 한계점을 극복하고, 비만 억제 효과가 높으며, 부작용이 적은 새로운 약물을 개발하기 위해 연구를 수행한 결과, 마황, 대황 및 자초의 혼합 추출물이 우수한 항 비만 효과가 있음을 확인함으로써 본 발명을 완성하였다.
Therefore, the inventors of the present invention have conducted studies to develop a new drug that overcomes the limitations of drugs developed for the treatment of obesity, has a high effect of inhibiting obesity, and has few side effects. As a result, it has been found that mixed extracts of mahwang, The present inventors have completed the present invention by confirming that there is an anti-obesity effect.
본 발명의 목적은 마황, 대황 및 자초의 혼합 추출물을 유효성분으로 포함하는 비만의 예방 또는 치료용 약학적 조성물을 제공하는 것이다. It is an object of the present invention to provide a pharmaceutical composition for preventing or treating obesity, which comprises a mixed extract of mahwang, rhubarb and grass as an active ingredient.
본 발명의 또 다른 목적은 마황, 대황 및 자초의 혼합 추출물을 유효성분으로 포함하는 비만의 예방 또는 개선용 식품 조성물을 제공하는 것이다.
Yet another object of the present invention is to provide a food composition for preventing or ameliorating obesity, which comprises a mixed extract of mahwang, rhubarb and grass as an active ingredient.
상기 목적을 달성하기 위하여, 본 발명은 마황, 대황 및 자초의 혼합 추출물을 유효성분으로 포함하는 비만의 예방 또는 치료용 약학적 조성물을 제공한다. In order to achieve the above object, the present invention provides a pharmaceutical composition for preventing or treating obesity, which comprises a mixed extract of mahwang, rhubarb and grass as an active ingredient.
또한 본 발명은 마황, 대황 및 자초의 혼합 추출물을 유효성분으로 포함하는 비만의 예방 또는 개선용 식품 조성물을 제공한다.
The present invention also provides a food composition for preventing or ameliorating obesity, which comprises a mixed extract of mahwang, rhubarb and grass as an active ingredient.
본 발명에 따른 마황, 대황 및 자초의 혼합 추출물은 고지방 식이로 유도한 비만 동물모델에서 간 독성을 일으키지 않으며, 체중 및 지방 조직의 무게를 감소시키고, 혈중 총 콜레스테롤 및 중성지방의 농도를 감소시키는 우수한 효과를 가지고 있어, 비만의 예방 또는 치료에 유용하게 사용될 수 있다.
The mixed extract of mahwang, rhubarb, and mulberry according to the present invention does not cause hepatotoxicity in an obesity animal model induced by a high fat diet, reduces weight and fat tissue weight, decreases total cholesterol and triglyceride concentration And can be usefully used for prevention or treatment of obesity.
도 1은 비만 동물모델에서 마황, 대황 및 자초의 혼합 추출물이 체중 증가에 미치는 영향을 나타낸 도이다.
도 2는 비만 동물모델에서 마황, 대황 및 자초의 혼합 추출물이 장간막 주변 백색지방조직(mesenteric adipose tissue, MAT)의 무게에 미치는 영향을 나타낸 도이다.
도 3은 비만 동물모델에서 마황, 대황 및 자초의 혼합 추출물이 생식기 주변 백색지방조직(epididymal adipose tissue, EAT)의 무게에 미치는 영향을 나타낸 도이다.
도 4는 비만 동물모델에서 마황, 대황 및 자초의 혼합 추출물이 식이효율에 미치는 영향을 나타낸 도이다.
도 5는 비만 동물모델에서 마황, 대황 및 자초의 혼합 추출물이 혈중 AST 수치에 미치는 영향을 나타낸 도이다.
도 6은 비만 동물모델에서 마황, 대황 및 자초의 혼합 추출물이 혈중 ALT 수치에 미치는 영향을 나타낸 도이다.
도 7은 비만 동물모델에서 마황, 대황 및 자초의 혼합 추출물이 혈중 총 콜레스테롤 농도에 미치는 영향을 나타낸 도이다.
도 8은 비만 동물모델에서 마황, 대황 및 자초의 혼합 추출물이 혈중 중성지방 농도에 미치는 영향을 나타낸 도이다.FIG. 1 is a graph showing the effect of mixed extracts of mahwang, rhubarb and shoot on body weight gain in an obesity animal model.
FIG. 2 is a graph showing the effect of the mixed extract of mahwang, rhubarb, and mulberry on the weight of the mesenteric adipose tissue (MAT) in the obese animal model.
FIG. 3 is a graph showing the effect of a mixed extract of mahwang, rhubarb and shoot on the weight of the epididymal adipose tissue (EAT) in the obese animal model.
Fig. 4 is a graph showing the effect of the mixed extract of manganese, rhubarb, and mulberry on the dietary efficiency in an obesity animal model.
FIG. 5 is a graph showing the effect of mixed extracts of mahwang, rhubarb and shoots on blood AST levels in an obesity animal model.
FIG. 6 is a graph showing the effect of mixed extracts of mahwang, rhubarb and grasses on serum ALT levels in obese animal models.
FIG. 7 is a graph showing the effect of mixed extract of mahwang, rhubarb, and shoot on blood total cholesterol concentration in an obesity animal model.
FIG. 8 is a graph showing the effect of mixed extracts of mahwang, rhubarb and shoot on blood triglyceride concentration in an obesity animal model.
본 발명은 마황, 대황 및 자초의 혼합 추출물을 유효성분으로 포함하는 비만의 예방 또는 치료용 조성물을 제공한다.The present invention provides a composition for preventing or treating obesity, which comprises a mixed extract of mahwang, rhubarb and grass as an active ingredient.
상기 조성물은 약학적 조성물 또는 식품 조성물을 포함한다.
The composition comprises a pharmaceutical composition or a food composition.
이하, 본 발명에 대하여 보다 상세히 설명한다. Hereinafter, the present invention will be described in more detail.
본 발명에서 '추출물'은 적절한 용매를 이용하여 마황, 대황 및 자초의 혼합물로부터 추출한 것이며, 예를 들어 마황, 대황 및 자초의 조추출물, 극성용매 가용 추출물 또는 비극성용매 가용 추출물을 모두 포함한다. 또한, 상기 추출물은 추출, 분획 또는 정제의 각 단계에서 얻어지는 모든 추출액, 분획 및 정제물, 그들의 희석액, 농축액 또는 건조물을 모두 포함하는 개념이다.In the present invention, the 'extract' is extracted from a mixture of mahwang, rhubarb and grass, using an appropriate solvent, and includes, for example, crude extracts of mahwang, rhubarb and grass extracts, polar solvent extracts or nonpolar solvent extracts. In addition, the above-mentioned extract is a concept that includes all extracts, fractions and tablets obtained in each step of extraction, fractionation or purification, their diluted solutions, concentrates or dried products.
본 발명의 조성물에서 유효성분인 마황, 대황 및 자초의 혼합 추출물은 하기와 같이 수득될 수 있다. Mixed extracts of mahwang, rhubarb and grass as active ingredients in the composition of the present invention can be obtained as follows.
먼저, 마황, 대황 및 자초를 각각 물로 세척하여 이물질을 제거한 후 그늘에서 건조하고 분쇄한다. 마황, 대황 및 자초는 재배한 것 또는 시판되는 것 등을 제한 없이 사용할 수 있다. 분쇄된 마황, 대황 및 자초를 혼합한 후, 적당한 양의 용매를 첨가하여 완전히 침지되도록 한다. 추출 용매로는 당업계에서 일반적으로 사용하는 무기 또는 유기용매를 제한없이 사용할 수 있으며, 물, 탄소수 1 내지 4의 알코올 또는 이들의 혼합용매로부터 선택된 용매가 바람직하다. 다음 상기에서 얻은 마황, 대황 및 자초의 혼합 추출물을 여과한 후 감압 농축하여 최종 추출물을 수득한다. 본 발명의 일 실시예에서는 마황, 대황 및 자초의 혼합 분말을 물에 녹여 이용하였다.First, the Chinese cabbage, rhubarb, and shoots are washed with water to remove impurities, followed by drying and crushing in the shade. Maquiladense, rhubarb and grasses may be cultivated or marketed without restriction. After mixing the ground parchment, rhubarb and rhizome, an appropriate amount of solvent is added to allow complete immersion. As the extraction solvent, any inorganic or organic solvent generally used in the art can be used without limitation, and a solvent selected from water, an alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof is preferable. Next, the mixed extracts of the above-mentioned extracts of mahwang, rhubarb and grass are filtered and concentrated under reduced pressure to obtain the final extract. In one embodiment of the present invention, a mixed powder of mahwang, rhubarb and grass powder was dissolved in water and used.
본 발명에 따른 조성물에 있어서, 상기 혼합 추출물은 바람직하게는 마황, 대황 및 자초를 30 % 내지 50 % : 10 % 내지 30% : 30% 내지 50%의 중량비로 혼합한 후 추출하여 수득할 수 있으며, 보다 바람직하게는 마황, 대황 및 자초를 40 % : 20 % : 40%의 중량비로 혼합한 후 추출하여 수득한다. 만약, 상기 혼합비율의 범위를 벗어나는 경우에는 마황, 대황 또는 자초를 단독으로 사용한 경우와 비교할 때 비만 치료 효과 면에서 큰 차이가 없으며, 부작용의 우려가 있어, 상기의 혼합비율일 때, 비만 치료 효과가 가장 우수하다.In the composition according to the present invention, the mixed extract may be obtained by mixing the mixture with a mixture of 30% to 50%: 10% to 30%: 30% to 50% , And more preferably 40%: 20%: 40% by weight, and then extracting the mixture. When the mixing ratio is out of the above range, there is no significant difference in the effect of treating obesity as compared with the case of using alone or in combination with magpie, rhubarb, or shoot, and there is a fear of side effects. Is the most excellent.
본 발명에 따른 마황, 대황 및 자초의 혼합 추출물은 고지방 식이로 유도한 비만 동물모델에서 간 독성을 일으키지 않으며, 체중 및 지방 조직의 무게를 감소시키고, 혈중 총 콜레스테롤 및 중성지방의 농도를 감소시키는 우수한 효과를 가지고 있다. The mixed extract of mahwang, rhubarb, and mulberry according to the present invention does not cause hepatotoxicity in an obesity animal model induced by a high fat diet, reduces weight and fat tissue weight, and decreases the total cholesterol and triglyceride concentrations in the blood Effect.
상기한 바와 같이, 본 발명에 따른 마황, 대황 및 자초의 혼합 추출물은 항비만 효과가 우수하므로, 비만의 예방 또는 치료에 유용한 의약품 또는 건강기능식품으로 사용될 수 있다.
As described above, the mixed extract of mahwang, rhubarb, and fennel according to the present invention is excellent in anti-obesity effect and thus can be used as a medicament useful for prevention or treatment of obesity or as a health functional food.
본 발명의 조성물은 마황, 대황 및 자초의 혼합 추출물과 함께 비만 억제 효과를 갖는 공지의 유효성분을 1종 이상 더 포함할 수 있다. The composition of the present invention may further comprise at least one known active ingredient having an obesity-suppressing effect together with a mixed extract of mahwang, rhubarb, and shoots.
본 발명의 조성물은 약학적 조성물의 제조에 통상적으로 사용하는 적절한 담체, 부형제 및 희석제를 더 포함할 수 있다. 또한 통상의 방법에 따라 산제, 과립제, 정제, 캡슐제, 현탁액, 에멀젼, 시럽, 에어로졸 등의 경구형 제형, 외용제, 좌제 및 멸균 주사용액의 형태로 제형화하여 사용될 수 있다. 당해 기술 분야에 알려진 적합한 제제는 문헌 (Remington's Pharmaceutical Science, 최근, Mack Publishing Company, Easton PA)에 개시되어 있는 것을 사용하는 것이 바람직하다. The compositions of the present invention may further comprise suitable carriers, excipients and diluents conventionally used in the manufacture of pharmaceutical compositions. In addition, it can be formulated in the form of powders, granules, tablets, capsules, suspensions, emulsions, oral preparations such as syrups and aerosols, external preparations, suppositories and sterilized injection solutions according to a conventional method. Suitable formulations known in the art are preferably those as disclosed in Remington ' s Pharmaceutical Science, recently, Mack Publishing Company, Easton PA.
본 발명의 약학적 조성물에 포함될 수 있는 담체, 부형제 및 희석제로는 락토오스, 덱스트로오스, 수크로오스, 소르비톨, 만니톨, 자일리톨, 에리스리톨, 말티톨, 전분, 아카시아 고무, 알지네이트, 젤라틴, 칼슘 포스페이트, 칼슘 실리케이트, 셀룰로오스, 메틸 셀룰로오스, 미정질 셀룰로오스, 폴리비닐 피롤리돈, 물, 메틸히드록시 벤조에이트, 프로필히드록시 벤조에이트, 탈크, 마그네슘 스테아레이트 및 광물유 등이 있다. 상기 조성물을 제제화할 경우에는 보통 사용하는 충진제, 증량제, 결합제, 습윤제, 붕해제, 계면활성제 등의 희석제 또는 부형제를 사용하여 조제된다. 경구투여를 위한 고형제제에는 정제, 환제, 산제, 과립제, 캡슐제 등이 포함되며, 이러한 고형제제는 상기 조성물에 적어도 하나 이상의 부형제 예를 들면, 전분, 칼슘 카보네이트, 수크로오스, 락토오스, 젤라틴 등을 섞어 조제된다. 또한 단순한 부형제 이외에 마그네슘 스테아레이트, 탈크 같은 윤활제들도 사용된다. 경구투여를 위한 액상 제제로는 현탁제, 내용액제, 유제, 시럽제 등이 해당되는데 흔히 사용되는 단순 희석제인 물, 리퀴드 파라핀 이외에 여러 가지 부형제, 예를 들면 습윤제, 감미제, 방향제, 보존제 등이 포함될 수 있다. 비경구 투여를 위한 제제에는 멸균된 수용액, 비수성용제, 현탁제, 유제, 동결건조 제제, 좌제가 포함된다. 비수성용제, 현탁제로는 프로필렌글리콜, 폴리에틸렌 글리콜, 올리브 오일과 같은 식물성 기름, 에틸올레이트와 같은 주사 가능한 에스테르 등이 사용될 수 있다. 좌제의 기제로는 위텝솔, 마크로골, 트윈 61, 카카오지, 라우린지, 글리세로제라틴 등이 사용될 수 있다. Examples of carriers, excipients and diluents that can be contained in the pharmaceutical composition of the present invention include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, Cellulose, methylcellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil. When the composition is formulated, it is prepared using a diluent such as a filler, an extender, a binder, a wetting agent, a disintegrant, a surfactant, or an excipient usually used. Solid formulations for oral administration include tablets, pills, powders, granules, capsules and the like, which are prepared by mixing at least one excipient such as starch, calcium carbonate, sucrose, lactose, It is prepared. In addition to simple excipients, lubricants such as magnesium stearate and talc are also used. Liquid preparations for oral administration include suspensions, solutions, emulsions, syrups and the like. Various excipients such as wetting agents, sweeteners, fragrances, preservatives and the like may be included in addition to water and liquid paraffin, which are simple diluents commonly used. have. Formulations for parenteral administration include sterilized aqueous solutions, non-aqueous solutions, suspensions, emulsions, freeze-dried preparations, and suppositories. Examples of the suspending agent include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like. Examples of suppository bases include withexol, macrogol, tween 61, cacao butter, laurin, glycerogelatin and the like.
본 발명에서 사용되는 용어 "투여"는 임의의 적절한 방법으로 개체에게 소정의 본 발명의 조성물을 제공하는 것을 의미한다.The term "administering" as used herein is meant to provide any desired composition of the invention to a subject in any suitable manner.
본 발명의 조성물의 바람직한 투여량은 개체의 상태 및 체중, 질병의 정도, 약물형태, 투여경로 및 기간에 따라 다르지만, 당업자에 의해 적절하게 선택될 수 있다. 예를 들어, 바람직한 효과를 위해서, 본 발명의 혼합 추출물은 1일 0.1 내지 10000 mg/kg(체중)의 양으로 투여할 수 있다. 상기 조성물의 투여는 하루에 한번 투여할 수도 있고, 수 회 나누어 투여할 수도 있다. The preferred dosage of the composition of the present invention varies depending on the condition and the weight of the individual, the degree of disease, the type of drug, the route of administration and the period of time, but can be appropriately selected by those skilled in the art. For example, for the desired effect, the mixed extract of the present invention can be administered in an amount of 0.1 to 10000 mg / kg (body weight) per day. The composition may be administered once a day, or divided into several doses.
본 발명의 조성물은 개체에게 다양한 경로로 투여될 수 있다. 투여의 모든 방식은 예상될 수 있는데, 예를 들면, 경구, 직장 또는 정맥, 근육, 피하, 자궁 내 경막 또는 뇌혈관 내 주사에 의해 투여될 수 있다. The compositions of the present invention may be administered to a subject in a variety of routes. All modes of administration may be expected, for example, by oral, rectal or intravenous, intramuscular, subcutaneous, intra-uterine dural or intracerebral injection.
본 발명의 조성물은 비만의 예방 및 치료를 위하여 단독으로, 또는 수술, 방사선 치료, 호르몬 치료, 화학 치료 및 생물학적 반응 조절제를 사용하는 방법들과 병용하여 사용할 수 있다.
The composition of the present invention can be used alone or in combination with methods using surgery, radiation therapy, hormone therapy, chemotherapy, and biological response modifiers for the prevention and treatment of obesity.
본 발명에서, '건강기능식품'이란 질병의 예방 및 치료, 생체방어, 면역, 병후의 회복, 노화 억제 등 생체조절기능을 가지는 식품을 말하는 것으로, 장기적으로 복용하였을 때 인체에 무해하여야 한다.In the present invention, the term 'health functional food' refers to a food having a biological control function such as prevention and treatment of disease, bio-defense, immunity, recovery of post-mortem and aging inhibition.
본 발명의 혼합 추출물은 비만의 예방 또는 개선을 목적으로 건강기능식품에 첨가될 수 있다. 본 발명의 혼합 추출물을 식품 첨가물로 사용할 경우, 상기 혼합 추출물을 그대로 첨가하거나 다른 식품 또는 식품 성분과 함께 사용될 수 있고, 통상적인 방법에 따라 적절하게 사용될 수 있다. 유효성분의 혼합양은 사용 목적 (예방, 건강 또는 치료적 처치)에 따라 적합하게 결정될 수 있다. 일반적으로, 식품 또는 음료의 제조 시에 본 발명의 혼합 추출물은 원료에 대하여 15 중량 % 이하, 바람직하게는 10 중량 % 이하의 양으로 첨가된다. 그러나, 건강 및 위생을 목적으로 하거나 또는 건강 조절을 목적으로 하는 장기간의 섭취의 경우에는 상기 범위 이하일 수 있으며, 안전성 면에서 아무런 문제가 없기 때문에 유효성분은 상기 범위 이상의 양으로도 사용될 수 있다.The mixed extract of the present invention can be added to a health functional food for the purpose of preventing or improving obesity. When the mixed extract of the present invention is used as a food additive, the mixed extract can be directly added or used together with other food or food ingredients, and can be suitably used according to a conventional method. The amount of the active ingredient to be mixed can be suitably determined according to the intended use (prevention, health or therapeutic treatment). Generally, the mixed extract of the present invention is added in an amount of not more than 15% by weight, preferably not more than 10% by weight based on the raw material, in the production of food or beverage. However, in the case of long-term intake for the purpose of health and hygiene or for the purpose of controlling health, the amount may be less than the above range, and since there is no problem in terms of safety, the active ingredient may be used in an amount exceeding the above range.
본 발명의 조성물이 포함될 수 있는 식품의 종류에는 특별한 제한은 없다. 본 발명의 혼합 추출물을 첨가할 수 있는 식품의 예로는 육류, 소시지, 빵, 초콜릿, 캔디류, 스낵류, 과자류, 피자, 라면, 기타 면류, 껌류, 아이스크림류를 포함한 낙농제품, 각종 스프, 음료수, 차, 드링크제, 알코올 음료 및 비타민 복합제 등이 있으며, 통상적인 의미에서의 건강식품을 모두 포함한다.There is no particular limitation on the type of food that the composition of the present invention can contain. Examples of the food to which the mixed extract of the present invention can be added include meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, gums, dairy products including ice cream, , A drink, an alcoholic beverage, and a vitamin complex, all of which include health foods in a conventional sense.
본 발명의 건강음료 조성물은 통상의 음료와 같이 여러 가지 향미제 또는 천연 탄수화물 등을 추가 성분으로서 포함할 수 있다. 상술한 천연 탄수화물은 포도당, 과당과 같은 모노사카라이드, 말토오스, 수크로오스와 같은 디사카라이드, 및 덱스트린, 사이클로덱스트린과 같은 천연 감미제나, 사카린, 아스파르탐과 같은 합성 감미제 등을 사용할 수 있다. 상기 천연 탄수화물의 비율은 본 발명의 조성물 100 ml 당 일반적으로 약 0.01 내지 10 g, 바람직하게는 약 0.01 내지 0.1 g 이다.The health beverage composition of the present invention may contain various flavors or natural carbohydrates as an additional ingredient such as ordinary beverages. The natural carbohydrates may be monosaccharides such as glucose and fructose, disaccharides such as maltose and sucrose, natural sweeteners such as dextrin and cyclodextrin, synthetic sweeteners such as saccharine and aspartame, and the like. The ratio of the natural carbohydrate is generally about 0.01 to 10 g, preferably about 0.01 to 0.1 g per 100 ml of the composition of the present invention.
상기 외에 본 발명의 조성물은 여러 가지 영양제, 비타민, 전해질, 풍미제, 착색제, 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알코올, 탄산 음료에 사용되는 탄산화제 등을 포함할 수 있다. 그 밖에 본 발명의 조성물은 천연 과일주스, 과일주스 음료 및 야채 음료의 제조를 위한 과육을 포함할 수 있다. 이러한 성분은 독립적으로 또는 조합하여 사용할 수 있다. 이러한 첨가제의 비율은 크게 중요하진 않지만 본 발명의 조성물 100 중량부 당 0.01 내지 0.1 중량부의 범위에서 선택되는 것이 일반적이다.
In addition to the above, the composition of the present invention may further contain various nutrients, vitamins, electrolytes, flavors, colorants, pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloid thickeners, pH adjusters, stabilizers, preservatives, glycerin, A carbonating agent used in a carbonated beverage, and the like. In addition, the composition of the present invention may comprise flesh for the production of natural fruit juices, fruit juice drinks and vegetable drinks. These components may be used independently or in combination. Although the ratio of such additives is not critical, it is generally selected in the range of 0.01 to 0.1 parts by weight per 100 parts by weight of the composition of the present invention.
이하 본 발명의 이해를 돕기 위하여 바람직한 실시예 및 실험예를 제시한다. 그러나 하기의 실시예 및 실험예는 본 발명을 보다 쉽게 이해하기 위하여 제공되는 것일 뿐, 실시예 및 실험예에 의해 본 발명의 내용이 한정되는 것은 아니다.
Hereinafter, preferred embodiments and experimental examples are provided to facilitate understanding of the present invention. However, the following examples and experimental examples are provided only for the purpose of easier understanding of the present invention, and the present invention is not limited by the examples and experimental examples.
실시예 1. 마황, 대황 및 자초의 혼합 추출물의 제조Example 1 Preparation of Mixed Extract of Mahwah, Rhubarb and Geranium
마황, 대황 및 자초는 화림제약(Busan, South Korea)에서 구입하였으며, 이를 각각 깨끗이 물로 세척하여 이물질을 제거한 후, 상온에서 건조하고 분쇄하였다. 분쇄된 마황, 대황 및 자초 분말을 40:20:40의 중량비로 혼합한 후, 물에 녹여 마황, 대황 및 자초의 혼합 추출물을 수득하였다. 상기 마황, 대황 및 자초의 혼합 추출물을 DF로 명명하였다.
Maehwang, rhubarb and grass were purchased from Hwangrim Pharmaceutical (Busan, South Korea), and each was cleaned with water to remove impurities, followed by drying and pulverizing at room temperature. The ground squash, rhubarb and grass powder were mixed at a weight ratio of 40:20:40, and then dissolved in water to obtain a mixed extract of magpie, rhubarb and shoot. The mixed extract of mahwang, rhubarb and rhizome was named DF.
실험예 1. 동물모델에서 비만 치료 효과를 검증하기 위한 실험 디자인Experimental Example 1. Experimental Design for Verifying the Effect of Obesity Treatment in an Animal Model
1-1. 실험 동물1-1. Experimental animal
㈜샘타코(샘타코바이오코리아 Inc., Korea)에서 공급한 7주령의 C57BL/6N 수컷 마우스를 구입하여 1주 간 실험실 환경에 적응하도록 한 후 사용하였다. 실험 기간 동안 온도 21±2 ℃, 습도 55±5 %, 환기 횟수 15∼17 회/hour, 조도 150~300 lux, 및 조명에 12시간의 명암(점등: 06:00, 소등: 18:00) 주기가 있는 실험실 환경에서 고형사료(Harlan, USA)와 물을 자유롭게 공급하였다.
A 7-week-old C57BL / 6N male mouse, supplied by Sam Taco Co., Ltd. (Korea), was purchased and adapted to the laboratory environment for 1 week. During the experimental period, the temperature was 21 ± 2 ℃, the humidity was 55 ± 5%, the ventilation frequency was 15 ~ 17 times / hour, illumination was 150 ~ 300 lux, (Harlan, USA) and water were fed ad libitum in a laboratory environment with a cycle.
1-2. 실험군 및 약물 투여1-2. Experimental group and drug administration
각 군당 9마리를 체중에 따라 무작위로 군 분리를 실시하였다. 8주 동안 정상군(normal group)은 10 Kcal% 지방을 포함하는 일반 식이를 공급하고, 대조군(control), 및 실험군 (DF(1), DF(2), DF(3))은 45 Kcal% 지방을 포함하는 고지방식이를 공급하여 비만을 유도하였다. 그 후, 대조군은 물을, 실험군은 각각 40, 80, 160 mg/kg의 상기 실시예 1에서 수득한 마황, 대황 및 자초의 혼합 추출물을 8주간 경구 투여하였다.
Nine of each group were randomly divided into groups according to body weight. The control group and the experimental groups (DF (1), DF (2), and DF (3)) received 45 Kcal% of normal diet, High fat diet, including fat, was used to induce obesity. Thereafter, the control group was orally administered with water, and the experimental group was orally administered with 40, 80 and 160 mg / kg of the mixed extract of mahwah, rhubarb and grass as obtained in Example 1 for 8 weeks.
실험예 2. 체중 증가량 측정Experimental Example 2. Measurement of weight gain
본 발명에 따른 마황, 대황 및 자초의 혼합 추출물(DF)이 체중 증가에 미치는 영향을 알아보기 위해, 약물을 투여하는 8주 동안 매주 2회씩 체중을 측정하였다. 그 결과를 도 1에 나타내었다. In order to examine the effect of the mixed extract of Daphnia magna, Rhubarb and Rhizoma extract according to the present invention on body weight gain, body weight was measured twice weekly for 8 weeks during the administration of the drug. The results are shown in Fig.
도 1에 나타낸 바와 같이, 정상군에 비해 대조군은 40일째부터 체중 증가량이 유의하게 증가하였다(P<0.05). 반면, 대조군에 비하여 마황, 대황 및 자초의 혼합 추출물 투여군(DF(1), DF(2), DF(3))은 통계적으로 유의하게 체중 증가량이 감소하였다. 이를 백분율로 환산할 경우, 대조군에 비해 DF(1)은 59.37%, DF(2)는 65.25%, DF(3)은 69.67%의 체중 감량 효과가 있는 것으로 나타났으며, 모든 농도에서 통계적으로 매우 현저한 체중 감량 효과가 있었고(P<0.001), DF의 농도 의존적인 체중 감량 효과를 확인하였다.
As shown in FIG. 1, the body weight gain was significantly increased in the control group from the 40th day (P <0.05). On the other hand, weight gain was statistically decreased in DF (1), DF (2), DF (3) groups compared with the control group. Concentrations of DF (1), DF (2) and DF (3) were 59.37%, 65.25% and 69.67%, respectively, when compared with the control group. There was a significant weight loss effect (P <0.001), confirming the concentration-dependent weight loss effect of DF.
실험예 3. 지방 조직 무게 측정Experimental Example 3. Measurement of fat tissue
실험 종료 후, 각 마우스를 부검하여 장간막 주변 백색지방조직(mesenteric adipose tissue, MAT) 및 생식기 주변 백색지방조직(epididymal adipose tissue, EAT)을 분리한 후, 그 무게를 측정하였다. 그 결과를 도 2 내지 도 3에 나타내었다.After the experiment, each mouse was autopsied to separate mesenteric adipose tissue (MAT) and epididymal adipose tissue (EAT) around the mesentery, and then weighed. The results are shown in FIG. 2 to FIG.
도 2에 나타낸 바와 같이, 정상군에 비해 대조군은 장간막 주변 백색지방조직(mesenteric adipose tissue, MAT)의 무게가 통계적으로 유의하게 증가하였다. 반면, 대조군에 비하여 마황, 대황 및 자초의 혼합 추출물 투여군은 통계적으로 유의하게 MAT의 무게가 감소하였으며, 구체적으로, 대조군에 비해 DF(1)은 14.71%, DF(2)는 14.67%, DF(3)은 15.03%의 MAT의 무게가 감소함을 확인하였다. As shown in FIG. 2, the weight of the mesenteric adipose tissue (MAT) around the mesentery was statistically significantly increased in the control group as compared with the normal group. Compared with the control group, the weight of MAT decreased statistically significantly compared to the control group. Specifically, the DF (1), DF (2) and DF (2) groups were 14.61% and 14.67% 3) showed that the weight of 15.03% MAT decreased.
또한, 도 3에 나타낸 바와 같이, 정상군에 비해 대조군은 생식기 주변 백색지방조직(epididymal adipose tissue, EAT)의 무게가 통계적으로 유의하게 증가하였다. 반면, 대조군에 비하여 마황, 대황 및 자초의 혼합 추출물 투여군은 통계적으로 유의하게 EAT의 무게가 감소하였으며, 구체적으로, 대조군에 비해 DF(1)은 4.08%, DF(2)는 3.99%, DF(3)은 3.05%의 EAT의 무게가 감소함을 확인하였다.
In addition, as shown in FIG. 3, the weight of the epididymal adipose tissue (EAT) around the genitalia was statistically significantly increased in the control group as compared with the normal group. Compared with the control group, the weight of EAT decreased significantly in the group treated with mixed extracts of mahwang, rhubarb, and shoots compared to the control group. Specifically, DF (1) was 4.08%, DF (2) 3) decreased the weight of EAT of 3.05%.
실험예 4. 식이효율 측정Experimental Example 4. Measurement of Dietary Efficacy
본 발명에 따른 마황, 대황 및 자초의 혼합 추출물(DF)이 식욕에 미치는 영향을 알아보기 위해, 체중은 매주 2회, 사료섭취량은 매주 1회 측정하였고, 이를 근거로 하여 식이효율을 계산하였다. 식이효율은 아래의 공식에 대입시켜 최종 체중증가량을 총 사료섭취량으로 나누어 산출하고 통계분석하였다. 그 결과를 도 4에 나타내었다.In order to examine the effect of the mixed extract of Daphnia magna, Rhododendron sulphate and Aspergillus according to the present invention on the appetite, the body weight was measured twice a week, the feed intake was measured once a week, and the dietary efficiency was calculated based on this. Dietary efficiency was calculated by dividing the final weight gain by the total feed intake by substituting into the formula below. The results are shown in Fig.
* 식이효율 (feeding efficiency ratio: FER%) = 체중증가량 (g)/사료섭취량(g)×1009,10)* Feeding efficiency ratio (FER%) = weight gain (g) / feed intake (g) × 1009,10)
도 4에 나타낸 바와 같이, 정상군에 비해 대조군은 식이효율이 증가하였으나, 대조군에 비하여 마황, 대황 및 자초의 혼합 추출물 투여군은 통계적으로 유의하게 식이효율이 감소함을 확인하였다. 식이효율이 낮다는 것은, 사료 섭취량이 많음에도 불구하고 체중의 증가가 적음을 의미하는 것인바, 상기 결과를 통하여 본 발명의 마황, 대황 및 자초의 혼합 추출물이 우수한 비만 조절 효과를 가지고 있음을 확인하였다.
As shown in FIG. 4, the dietary efficiency of the control group was increased compared to that of the normal group, but the dietary efficiency was decreased statistically in the group administered with the mixed extract of mahwang, rhubarb and grass as compared with the control group. The fact that the dietary efficiency is low means that the body weight gain is small despite the high feed intake. The above results indicate that the mixed extract of the present invention has excellent obesity control effect Respectively.
실험예 5. 혈액 생화학 분석Experimental Example 5. Blood Biochemical Analysis
실험 종료 후, 혈액 채취를 위해 각 마우스를 12시간동안 절식한 뒤 디에틸에테르로 마취한 다음, 심장에서 혈액 1 ml을 채취하였다. 상기 혈액을 30분 이상 실온에서 방치한 후, 고속원심분리기(Micro12, Hanil, Korea)를 이용하여 3000rpm에서 10분간 원심 분리하여 혈장을 분리하였다. 분리된 혈장은 냉동고(-20℃)에 보관하고 혈액생화학분석기(Modular analytics, Roche, Germany)를 사용하여 AST(asparate aminotransferase), ALT(alanine aminotransferase), 총 콜레스테롤(total cholesterol) 및 중성지방(triglyceride)의 혈중 농도를 각각 측정하였다. 그 결과를 도 5 내지 도 8에 나타내었다. After the end of the experiment, each mouse was fasted for 12 hours for blood sampling, anesthetized with diethyl ether, and then 1 ml of blood was collected from the heart. The blood was allowed to stand at room temperature for 30 minutes or more, and centrifuged at 3000 rpm for 10 minutes using a high-speed centrifuge (Micro12, Hanil, Korea) to separate plasma. Separated plasma was stored in a freezer (-20 ° C) and analyzed by AST (asparate aminotransferase), alanine aminotransferase (ALT), total cholesterol and triglyceride using a blood biochemical analyzer (Modular analytics, Roche, Germany) ) Were measured. The results are shown in Figs. 5 to 8. Fig.
도 5 내지 도 8에 나타낸 바와 같이, 마황, 대황 및 자초의 혼합 추출물 투여군은 간 손상의 지표인 혈장 내 AST 및 ALT 농도는 대조군과 통계적으로 유의한 차이가 없었으나, 총 콜레스테롤 농도 및 중성지방 농도는 대조군에 비해 통계적으로 유의하게 낮게 나타남을 확인하였다.
As shown in FIGS. 5 to 8, the AST and ALT concentrations in plasma, which are indicators of liver damage, were not statistically different from the control group, but the total cholesterol concentration and triglyceride concentration Were statistically significantly lower than those of the control group.
이상의 실험 결과를 통하여, 본 발명의 마황, 대황 및 자초의 혼합 추출물은 간 독성이 없는 안전한 물질이면서도, 비만 동물모델에서 체중 및 지방 조직의 무게를 감소시키며, 혈중 총 콜레스테롤 및 중성지방의 농도를 감소시키는 등 지질 대사를 개선시켜, 우수한 항비만 효과를 가지고 있음을 확인하였다.
From the above experimental results, it can be seen that the mixed extract of mahwang, rhubarb, and ashes of the present invention is a safe substance without liver toxicity, but also reduces the weight and fat tissue weight in obese animal models and decreases the total cholesterol and triglyceride levels And lipid metabolism, and it has been confirmed that it has excellent anti-obesity effect.
이하 본 발명의 약학적 조성물 및 식품 조성물의 제제예를 설명하나, 본 발명을 한정하고자 함이 아닌 단지 구체적으로 설명하고자 함이다.
Hereinafter, the pharmaceutical composition of the present invention and the pharmaceutical composition of the food composition will be described, but the present invention is not intended to be limited but is specifically described .
제제예 1. 약학적 제제의 제조Formulation Example 1. Preparation of pharmaceutical preparations
1. 산제의 제조 1. Manufacturing of powder
마황, 대황 및 자초의 혼합 추출물 20 mgMixed extract of mahwang, rhubarb and
유당 100 mg
탈크 10 mg
상기의 성분들을 혼합하고 기밀포에 충진하여 산제를 제조한다.
The above components are mixed and filled in airtight bags to prepare powders.
2. 정제의 제조2. Preparation of tablets
마황, 대황 및 자초의 혼합 추출물 10 mgMixed extract of mahwang, rhubarb and
옥수수전분 100 mg
유당 100 mg
스테아린산 마그네슘 2 mg
상기의 성분들을 혼합한 후 통상의 정제의 제조방법에 따라서 타정하여 정제를 제조한다.
After mixing the above components, tablets are prepared by tableting according to the usual preparation method of tablets.
3. 캡슐제의 제조3. Preparation of capsules
마황, 대황 및 자초의 혼합 추출물 10 mgMixed extract of mahwang, rhubarb and
결정성 셀룰로오스 3 mg
락토오스 14.8 mgLactose 14.8 mg
마그네슘 스테아레이트 0.2 mgMagnesium stearate 0.2 mg
통상의 캡슐제 제조방법에 따라 상기의 성분을 혼합하고 젤라틴 캡슐에 충전하여 캡슐제를 제조한다.
The above components are mixed according to a conventional capsule preparation method and filled in gelatin capsules to prepare capsules.
4. 주사제의 제조4. Preparation of injections
마황, 대황 및 자초의 혼합 추출물 10 mgMixed extract of mahwang, rhubarb and
만니톨 180 mg180 mg mannitol
주사용 멸균 증류수 2974 mgSterile sterilized water for injection 2974 mg
Na2HPO42H2O 26 mgNa 2 HPO 4 2H 2 O 26 mg
통상의 주사제의 제조방법에 따라 1 앰플당 (2 ml) 상기의 성분 함량으로 제조한다.
(2 ml) per 1 ampoule in accordance with the usual injection preparation method.
5. 액제의 제조5. Manufacture of liquids
마황, 대황 및 자초의 혼합 추출물 20 mgMixed extract of mahwang, rhubarb and
이성화당 10 g10 g per isomer
만니톨 5 g5 g mannitol
정제수 적량Purified water quantity
통상의 액제의 제조방법에 따라 정제수에 각각의 성분을 가하여 용해시키고 레몬향을 적량 가한 다음 상기의 성분을 혼합한 다음 정제수를 가하여 전체를 정제수를 가하여 전체 100 ml로 조절한 후 갈색병에 충진하여 멸균시켜 액제를 제조한다.
Each component was added and dissolved in purified water according to the usual liquid preparation method, and the lemon flavor was added in an appropriate amount. Then, the above components were mixed, and purified water was added thereto. The whole was added with purified water to adjust the total volume to 100 ml, And sterilized to prepare a liquid preparation.
제제예 2. 식품 제제의 제조Formulation Example 2. Preparation of food preparation
1. 건강식품의 제조 1. Manufacture of health food
마황, 대황 및 자초의 혼합 추출물 100 mgMixed extract of mahwang, rhubarb and
비타민 혼합물 적량Vitamin mixture quantity
비타민 A 아세테이트 70 g 70 g of vitamin A acetate
비타민 E 1.0 mgVitamin E 1.0 mg
비타민 B1 0.13 mgVitamin B1 0.13 mg
비타민 B2 0.15 mg0.15 mg of vitamin B2
비타민 B6 0.5 mgVitamin B6 0.5 mg
비타민 B12 0.2 g 0.2 g of vitamin B12
비타민 C 10 mg
비오틴 10 g Biotin 10 g
니코틴산아미드 1.7 mgNicotinic acid amide 1.7 mg
엽산 50 g Folate 50 g
판토텐산 칼슘 0.5 mgCalcium pantothenate 0.5 mg
무기질 혼합물 적량Mineral mixture quantity
황산제1철 1.75 mg1.75 mg of ferrous sulfate
산화아연 0.82 mg0.82 mg of zinc oxide
탄산마그네슘 25.3 mgMagnesium carbonate 25.3 mg
제1인산칼륨 15 mgPotassium monophosphate 15 mg
제2인산칼슘 55 mgSecondary calcium phosphate 55 mg
구연산칼륨 90 mgPotassium citrate 90 mg
탄산칼슘 100 mg
염화마그네슘 24.8 mgMagnesium chloride 24.8 mg
상기의 비타민 및 미네랄 혼합물의 조성비는 비교적 건강식품에 적합한 성분을 바람직한 실시예로 혼합 조성하였지만, 그 배합비를 임의로 변형 실시하여도 무방하며, 통상의 건강식품 제조방법에 따라 상기의 성분을 혼합한 다음, 과립을 제조하고, 통상의 방법에 따라 건강식품 조성물 제조에 사용할 수 있다.
Although the composition ratio of the above-mentioned vitamin and mineral mixture is comparatively mixed with a composition suitable for health food as a preferred embodiment, the compounding ratio may be arbitrarily modified, and the above ingredients are mixed according to a conventional method for producing healthy foods , Granules can be prepared and used in the manufacture of health food compositions according to conventional methods.
2. 건강음료의 제조2. Manufacture of health drinks
마황, 대황 및 자초의 혼합 추출물 100 mgMixed extract of mahwang, rhubarb and
비타민 C 15 gVitamin C 15 g
비타민 E(분말) 100 gVitamin E (powder) 100 g
젖산철 19.75 g19.75 g of ferrous lactate
산화아연 3.5 g3.5 g of zinc oxide
니코틴산아미드 3.5 gNicotinic acid amide 3.5 g
비타민 A 0.2 gVitamin A 0.2 g
비타민 B1 0.25 gVitamin B1 0.25 g
비타민 B2 0.3 gVitamin B2 0.3 g
물 정량Water quantification
통상의 건강음료 제조방법에 따라 상기의 성분을 혼합한 다음, 약 1시간 동안 85℃에서 교반 가열한 후, 만들어진 용액을 여과하여 멸균된 2L 용기에 취득하여 밀봉 멸균한 뒤 냉장 보관한 다음 본 발명의 건강음료 조성물 제조에 사용한다.The above components were mixed according to a conventional health drink manufacturing method, and the mixture was stirred and heated at 85 DEG C for about 1 hour. The resulting solution was filtered and sterilized in a sterilized 2 L container, ≪ / RTI >
상기 조성비는 비교적 기호음료에 적합한 성분을 바람직한 실시예로 혼합 조성하였지만 수요계층이나, 수요국가, 사용용도 등 지역적, 민족적 기호도에 따라서 그 배합비를 임의로 변형 실시하여도 무방하다.
Although the compositional ratio is relatively mixed with a component suitable for a favorite drink, it is also possible to arbitrarily modify the compounding ratio according to the regional or national preference such as the demand class, the demanding country, and the use purpose.
Claims (5)
A pharmaceutical composition for the prevention or treatment of obesity, which comprises a mixed extract of squalus, rhubarb and grass as an active ingredient.
The pharmaceutical composition for preventing or treating obesity according to claim 1, wherein the extract is extracted with at least one solvent selected from the group consisting of water, an alcohol having 1 to 4 carbon atoms, and a mixed solvent thereof.
The pharmaceutical composition for preventing or treating obesity according to claim 1, wherein the saccharin, rhubarb, and shoots are mixed in a weight ratio of 30% to 50%: 10% to 30%: 30% to 50%.
A food composition for preventing or ameliorating obesity, which comprises a mixed extract of corn, rhubarb and rhubarb as an active ingredient.
5. The food composition for preventing or improving obesity according to claim 4, wherein the saccharin, rhubarb, and shoots are mixed in a weight ratio of 30% to 50%: 10% to 30%: 30% to 50%.
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| KR1020140027116A KR101591460B1 (en) | 2014-03-07 | 2014-03-07 | Composition comprising mixture extract of Ephedra sinica, Rheum palmatum L and Arnebia euchroma for preventing or treating obesity |
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