KR20150102362A - Ginsenoside extract method from the damaged wild ginseng - Google Patents

Abstract

The present invention relates to a method for extracting a maximum content of ginsenoside from damaged wild cultivated ginseng, in which mineral activated water obtained by distilling sea spa water is included, and a low temperature vacuum extracting process is performed on frozen and dried wild cultivated ginseng by using the mineral activated water as a solvent, thereby extracting a maximum content of ginsenoside.

Description

Extraction method of ginsenoside extract from the wild ginseng [

The present invention relates to a method for converting ginsenoside ginseng to ginsenosides by converting ginsenoside to ginsenoside by using low-temperature vacuum using mineral active water, The present invention relates to a method for extracting ginsenosides having a maximum content of waxy ginseng having a high content of senosides.

Ginseng (ginseng) is a perennial plant belonging to Araliaceae. It is semi-ominous vegetation with a height of about 60cm. Many are grown for medicinal purposes. The height is 60 centimeters, and each stem grows straight one year, and 3-4 leaves turn at its end. Leaves are long with petiole, and leaf blades are divided into 5 pieces and form leaflets with long leaves. There are hairs on the veins in front of leaves. In summer one flower stalk comes out and at its end, 4-40 pale yellow-green tiny flowers hang on mountain-shaped inflorescence. There are 5 petals and stamens, 1 pistil and ovary is lower. The fruit is flattened to the nucleus and becomes mature when it matures. Root is medicinal, and its form is human, so it is called ginseng. It is a plant with strong branching ability. Its root shape varies according to age and harvesting time is 4-6 years. The Korean red ginseng, which is used as a raw material, is six years old. Six-year-old muscles are 7-10 centimeters in length, 2.5 centimeters in diameter, 34 centimeters in root length, and 80 grams in weight. Ginseng grows every year in the undergrowth stem and leaves fall and stem in the fall. Ginseng is divided into red ginseng and white ginseng according to the processing method, and red ginseng is made by steaming ginseng with steam based on Oriental medicine theory. Ginseng is widely used as a tonic, heart, correction of calm and sedative drugs, and is used as a promotion drug for depression of metabolic function caused by weakness of gastrointestinal function. It is used for promotion of illness, bad digestion, vomiting, chest pain, And the like.

In the world ginseng market, China is a large ginseng cultivation area, which is a major ginseng producer country, which accounts for 70% of the world ginseng production, and has developed rapidly in light of the ginseng researchers of many universities and research institutes. . Among the 614 papers published in 2010 on ginseng (SCI), China is in the trend of catching up to 216 of South Korea, which is the 175th. In the situation that the difference of ginseng production with China can not be reduced, it is necessary to maintain technological superiority with China to preserve the leading position in the world ginseng market. The active ingredient of ginseng is known as ginsenoside in 1963, and the pharmacological effect of ginsenoside has been studied. In addition to ginseng roots, ginsenosides are also found in leaves, stems, fruit and buds, and the chemical structure of 182 ginsenosides (ginsenosides) was found in ginseng. Based on their chemical structures, saponin compounds can be divided into protopanaxadiol (PD), protopanaxatriol (PT), and oleanane groups. These ginsenosides exhibited pharmacological activities such as antitumor and cancer cell metastasis inhibition, antidiabetic efficacy, blood pressure control efficacy, antistress and brain disease efficacy.

It is known that the ginseng ginseng which is currently distributed is grown by spraying the seeds of wild ginseng in the wild. Its efficacy is similar to that of natural wild ginseng, and the content of ginsenoside is four times higher than that of red ginseng. However, in the process of carving the ginseng ginseng, the price of the ginseng ginseng with damaged trauma is reduced to 1/5 to 1/10 of its original value.

The object of the present invention is to solve the above problems and to provide a method of extracting frozen dried ginseng from frozen dried ginseng by using low temperature vacuum extraction process using mineral active water distilled from sea water, The ginsenoside of the goat ginseng is twice or more than the conventional atmospheric extraction method The present invention provides a method for extracting ginsenosides having a maximum content from a ginseng rosemary extract and a ginsenoside obtained therefrom.

Another object of the present invention is to provide a method for extracting lyophilized scalloped ginseng from low temperature extractions using mineral active water distilled from seawater hot water as a solvent and then conducting a low temperature vacuum extraction process using mineral active water as a solvent, The present invention provides a method for extracting ginsenosides having a maximum content from waked goat ginseng which allows the side to be extracted 4 to 6 times as much as the conventional atmospheric pressure extraction method, and a ginsenoside obtained therefrom.

To this end, the present invention relates to a method for extracting ginsenosides from a ginsenoside extract obtained by subjecting a ginseng ginseng lyophilized from a minerally active water to a low-temperature vacuum extraction process with a mineral active water distilled from seawater hot water, A senoside extraction method is provided.

The present invention also relates to a process for producing a ginsenosides product, which comprises a step of extracting a freeze-dried ginseng from a low temperature with a mineral active water and then extracting the mineral active water with a solvent at a low temperature, Of the ginsenosides of the present invention.

The present invention relates to a method for extracting ginsenoside from freeze-dried ginseng ginseng by freeze-drying, extracting mineral water with distilled water from seawater, To maximize the ginsenoside extract, and to use the ginsenosides extracted by lyophilization of the ginseng ginseng to be industrially used.

The present invention relates to a method for extracting mineral ginseng from livestock ginseng by freeze-drying, extracting mineral water from distilled water of sea water from low-temperature freeze-dried ginseng with a solvent and then vacuum-extracting it at low temperature to 4 to 6 times The ginsenosides are further extracted to maximize ginsenoside extraction.

The present invention relates to a method for preparing a freeze-dried soybean ginseng, comprising the steps of: lyophilizing the freeze-dried soybean ginseng; and freezing-drying the ginsenoside extract .

1 is a process diagram of the present invention,
2 is a process diagram showing another example of the present invention.

As the solvent used in the present invention, the seawater hot spring water of Yonggung Hot Spring, Mineral activated water converted into mineral-rich active water is used.

Mineral activated water produced from seawater hot spring water is produced by mineral active water by distilling seawater hot spring water which is watered from granite bar which formed stalagmite, and has cleanliness, eutrophication and aging properties. In other words, the plant Frankton has a photosynthetic action in the condition of more than 1% of the light entering the sea surface and the food chain is formed. It is about 1% at the depth of 150m and no sunlight at the depth of 200m or less. The seawater is characterized by the clean nature of seawater hot spring water, where deep seawater does not flow through the underground granite, and because there is hot spring water where photosynthesis can not take place, , It takes about 100 million years for the seawater hot spring water generated from Seokmo Island to meet the surface water again by the eruption, and the concentrated natural minerals are present in the form of ion and are absorbed 100% in the human body. Mineral-active mineral water rich in minerals is removed from the salt water in the seawater. It was used to try to extract the goats wild ginseng.

In addition, the minerals of hot spring water have fermentative properties, and when they extract natural materials, they react with sugar and alcohol molecules in natural materials to increase fermentability.

Mineral active water obtained from seawater hot spring water is rapidly absorbed and water is supplied quickly to the cells and the nutrient delivery rate is fast. Especially, calcium / potassium content is 2 to 3 times higher than general water and 20 times higher than general water. It is an effective ingredient for skin cleansing and regenerating ability, penetrates deep into the stratum corneum. Therefore, it penetrates the skin of the ginseng ginseng when it extracts ginsenoside of the goat ginseng. It penetrates into the structure and has superior extraction ability than methanol, ethanol and butanol. In the process, mineral components react with sugar and alcohol molecules in the structure to increase the fermentability and convert some of the ginsenosides to Rg and Rh derivatives, thereby increasing the overall ginsenoside content.

Mineral activated water used in the present invention was obtained by distilling sea water hot spring water of Dragon Palace hot spring by MVR method.

In addition, it was confirmed that when the freeze-drying method was used before the extraction process, the ginsenoside extract was 2.5 times as much as the samples before use in the extraction process. This phenomenon can be explained by the fact that during the freeze-drying process, the concentration of ginsenosides is higher than that of natural dry samples due to the self-concentration of sugar and alcohol components in the ginseng ginseng by freezing, .

FIG. 1 is a process diagram showing an example of the present invention. FIG. 2 is a process diagram showing another example of the present invention in which the low temperature extraction process is further performed in step 1 in the process of FIG. 1, The lyophilization process in which the goat ginseng is carried out at -50 ° C to -40 ° C for 12 to 24 hours is carried out in a step. (The lyophilization system uses only known techniques.

Next, the low-temperature extraction step of extracting the seawater springs water at 50 to 60 ° C for 6 to 12 hours with the mineral active water distilled in a mechanical vapor recompressor (MVR) as a solvent is carried out in step 2 (b) Since the decompression compressor is a known system, only the name is given and the illustration and description of the system for the low temperature extraction are omitted. (Step b is omitted in the process of Fig. 1)

Following the water increased mechanical springs base compressor with the number of that activity mineral distilled (MVR Mechanical vapor Recompressor) as a solvent, 50 ~ 70 ℃, 8 ~ 24 sigan, 10 ^-1 ~ 10 ^-5 torr vacuum extraction process at a low temperature Step c.

Then, the cooling step is performed in step d, followed by cooling to room temperature, and the filter step for removing foreign matters is performed in step e. Since the adjustment or dilution of the concentration depends on the convenience of the manufacturer, the description of the concentration and the like is omitted.

Process condition test to complete the present invention

1. Freeze-drying temperature: -50 ^o C to -10 ^o C

2. Freeze-drying time: 12 to 72 hours

3. The low-temperature extraction temperature: 40 ^o C ^o C~90

4. Low temperature extraction time: 6 to 48 hours

5. The low-temperature vacuum extraction temperature: 50 ^o C ^o C~120

6. Low temperature vacuum extraction time: 6 to 48 hours

7. Low temperature vacuum extraction vacuum: 10 ^-1 ~ 10 ^-5 torr

Based on the above conditions,

1. Freeze-drying temperature: -50 ^o C ~ 40 ^o C

If the freeze-drying temperature is less than 50 ^° C, the freeze-drying equipment system uses a commercial system that operates up to -50 ^° C. However, once the equipment is under 50 ^° C, a separate equipment system must be attached. And the processing cost is 10 times higher than the processing cost of 1 kg. In addition, the porosity of the ginseng ginseng, which is composed of porous fibers when freeze-dried at less than 50 ^o C, becomes larger, so that it becomes easier to absorb moisture after drying, so that the constitutional components are easily changed and oxidized easily during long-term storage, and the ginsenoside content . In addition, the physical and chemical changes of the goat ginseng are many, and the hot smelting of the ginseng ginseng, the loss of the fragrance ingredient, and the disappearance of the ingredient are increased.

When the freeze-drying temperature is between -40 ^° C and -10 ^° C, the desired ginsenoside yield of the extract can not be obtained. For example, at -20 ^° C, the ginsenoside of about 1.5 times the optimum ginsenoside- Was decreased.

2. Freeze-drying time: 12 to 24 hours

If the freeze-drying time is less than 12 hours, the yield is not uniform due to the freeze-dried amount and the optimum condition of the extract is satisfied after 12 hours. More preferably, the freeze-drying time of the process optimum condition is 18 hours to 24 hours, which is an optimum condition in the present invention.

If it exceeds 24 hours, energy waste and porosity rate are further increased to increase moisture absorption, and component disappearance occurs.

3. Low Temperature Extraction Temperature: 50 ^o C ~ 60 ^o C

The low temperature extraction process penetrates into the fiber from the surface by the solvents used for the extraction on the skin surface of freeze-dried goat ginseng and on the porous surface composed of freezing, and the respective constituent tissues of the fiber are hot-rolled to form a saccharide component The extraction time of the extract from the fibrous tissue requires a time of 1.5 to 2 times the ginsenoside content in the case of low temperature vacuum extraction after the low temperature extraction.

The optimum conditions of low temperature extraction looks for this effect is 50 ^o to ^o C~60 C, 50 ^o C lower than when the non-economic and as much time it takes on the screen surface due to the solvent hot rolling step, exceed 60 ^o C with a carbohydrate component Since ginsenosides are extracted together, they affect the optimum content. Since the present invention is intended for extracting ginsenosides having high purity, mixing of saccharide fiber and ginsenoside results in a reduction of the optimum ginsenoside yield of 1.5-2 times, which is the object of the present invention.

4. Low temperature extraction time: 6 hours ~ 12 hours

In case of less than 6 hours, it is insufficient for the hot-rolling process, and the extraction rate is lowered. When the extraction solvent exceeds 12 hours, the non-solvent surface and the extracting solvent cause the senoside extraction through epidermal penetration, And the quality of the product is deteriorated.

5. Low temperature vacuum extraction temperature: 50 ^o C ~ 90 ^o C

When the extraction temperature is lower than 50 ^o C in the low-temperature vacuum extraction step, the optimum extraction yield of ginsenoside is lowered. When the extraction temperature exceeds 90 ^o C Various decomposition reactions by the solvent extraction action are maximized and the optimum extraction yield is reduced. Particularly, the condition of the present invention is that the processing at a low-temperature vacuum minimizes all the additional reactions, thereby reducing the loss of aroma and aroma sensory materials, less physical and chemical changes, and the reduction of the aroma component, And the like can be minimized.

6. Low temperature vacuum extraction time: 8 ~ 24 hours

In the low temperature vacuum extraction time, less than 8 hours is an extraction time with insufficient time in relation to the yield of extract, and more than 24 hours is accompanied by an extraordinary reaction with an uneconomical surface, resulting in increased browning, protein deformation, There are many physical and chemical changes, and it leads to the hot smelting of the ginseng ginseng, the loss of the fragrance ingredient and the disappearance of the ingredient.

7. Low temperature vacuum extraction Vacuum: 10 ^-One ~ 10 ^-5 torr

Exceeding 10 ^-5 torr is uneconomical, and below 10 ^-1 torr results in lower yields for extraction.

In the present invention Used  Component ratio of mineral active water

division Detection amount (mm) ingredient Sea water hot spring water Mineral active water Na + 4,650 7.4 K + 93.8 1.6 Ca ^{2 +} 3,120 67 Mg ^{2 +} 254 14 Fe ^{2 +} 0.7 0.1 Zn ^{2 +} 0.1 0.07 Mn ^{2 +} 2.05 0.001 Sr ^{2 +} 75 54 Si ^{4 +} 13.2 1.0 Li ⁺ 9.1 5.2 Cl ^- 12,700 27

Hot spring water in the present invention in Table 1 is a component ratio of the water of the hot spring water ㈜ palace springs developed Ganghwa seokmodo samsanmyeon maeeumri, this mineral-bar can be seen rich mineral ordination activity, in particular Li ^+, Sr ^{2 +,} It is confirmed that the detection amount of Zn ^{2 +} is almost 50% or more of the seawater hot spring water component.

The low temperature vacuum extraction method

Low temperature vacuum extraction generally boils water at 100 ° C, but starts to boil at low temperature (65 ° C) when vacuum is removed. The boiling of water has the effect of extracting more than the boiling at 100 ℃ because of the effect of water molecular motion, which causes red ginseng to beat.

Molecular motion state of matter through low temperature vacuum extraction

Low temperature vacuum extraction of the extract, Pressureless (atmospheric) extraction , Comparison of pressure extraction

To the 500 g of goat mountain ginseng were added 20 L of water and they were added under the different conditions of low temperature vacuum (50 ℃ ~ 90 ℃ for 24 hours), no pressure atmospheric pressure extraction (100 ℃ for 24 hours) and pressure extraction (120 ℃ for 24 hours) As a result of the extraction experiment, a color change which can be clearly distinguished apparently occurred severely. This change in color is thought to be the result of a galvanic reaction.

Comparison of brownness and turbidity of extracts Photographs and graphs

To investigate the degree of change of browning reaction, the absorbance of the extracts was measured at 440 nm and 660 nm using a Spectrophotometer (HeLios Gamma). As a result of the measurement of the brown and turbidity, the extracts from the pressure were 5 times higher than the extracts from the low temperature vacuum, and it was confirmed that the extracts were significantly changed. If the saponin is extracted at a temperature above 100 ° C, the saponin is not extracted, but the saponin component is modified and destroyed to extract another type of modified saponin. When the total saponin test is carried out, Extraction is carried out at a temperature of 50 ° C to 90 ° C. Even at a low temperature, there is a time suitable for extraction. Even if the temperature is lower than 90 캜, if the exposure is performed for a long time at that temperature, there is a change in the effective component as well as at a temperature higher than 100 캜. Therefore, it is necessary to study the optimum extraction temperature and time for each raw material, and the present invention has been completed under the conditions of the optimum extraction method.

Optimum extraction condition

Condition result Raw
Crushing degree As the raw material is crushed, the contact area between the solvent and the solute becomes wider, so that the diffusion rate increases and the extraction rate increases. However, the solubility selectivity of the solvent decreases and the extraction of unnecessary components increases. Extraction temperature The higher the temperature, the better the extraction, but the dissolution of the unwanted components increases and leads to the inactivation of the weak functional component of the heat. Extraction time The longer the time, the more diffusion of the impurities increases and the concentration of the effective component decreases. Extraction concentration When the ratio of the solvent of the raw material is increased, the concentration difference becomes larger and the diffusion rate becomes faster, but the unit throughput becomes smaller and the solution to be concentrated becomes more and the productivity is lowered. Solvent pH Acidic solvents increase the solubility of alkaloids, phenols and flavonoids and increase the extraction efficiency of ginsenosides in basicity.

In the freeze-drying process, Gin Senocide  Extraction comparison

Freezing temperature: -50 ^o C

Freeze-drying time: 24 hours

Solvent: distilled water

Extraction conditions: 100 ^o C, 24 hours / 1 time, repeated 3 times extraction of the same sample, atmospheric pressure, 500g / 20L (capacity)

Gin Senocide Extraction (%) Before lyophilization After lyophilization Rg1 0.86 1.6 Re 1.12 1.97 Rb1 1.1 2.3 Rb2 - - Rg2 (s) - 0.003 Rg3 0.001 0.02 Rb3 1.1 2.1 Rh1 0.02 0.3 Rd 0.03 0.1 Rh2 (s) - 0.001 Rc 0.004 0.01

It can be seen from Table 3 that the extraction amount at the atmospheric pressure heated atmospheric pressure extraction using 500 g of the freeze-dried goat ginseng extract was more than twice as much as that at the atmospheric pressure heated atmospheric pressure extraction using 500 g of the non-lyophilized goat ginseng.

Depending on the low-temperature vacuum process conditions Gin Senocide  Extraction comparison

Low temperature Vacuum temperature: 70 ^o C

Low temperature vacuum extraction time: 24 hours

Vacuum condition: 10 ^-2 torr

Solvent: distilled water

Extraction Capacity: 500g / 20L, Sample: Production Yangsan Gam 500g

Gin Senocide Extraction (%) Atmospheric pressure heating extraction process (100 ^o C) Low temperature vacuum extraction process (70 ^o C) Rg1 0.86 2.0 Re 1.12 2.4 Rb1 1.1 1.97 Rb2 - 0.01 Rg2 (s) - 0.01 Rg3 0.001 0.015 Rb3 1.1 2.5 Rh1 0.02 0.8 Rd 0.03 0.1 Rh2 (s) - 0.005 Rc 0.004 0.01

It can be seen that the extract is extracted more than twice as much as the extracting amount in the low pressure vacuum extraction process (70 ^o C) using the non-lyophilized goat ginseng at 100 ^° C in the atmospheric pressure heating process.

Freeze drying process, low temperature extraction process Gin Senocide  Extraction comparison

Step a:

Freezing temperature: -50 ^o C

Freeze-drying time: 24 hours

Step b:

Low Temperature Extraction Temperature: 60 ^o C

Low temperature extraction time: 8 hours

Solvent: distilled water

Gin Senocide Extraction (%) Low temperature vacuum extraction process (70 ^o C)
Production Yangsan gam 500g use Freeze-drying / low-temperature treatment Extraction process (60 ^o C)
Freeze-dried goat 500 g ginseng Rg1 2.0 0.92 Re 2.4 1.2 Rb1 1.97 1.6 Rb2 0.01 - Rg2 (s) 0.01 - Rg3 0.015 0.001 Rb3 2.5 0.9 Rh1 0.8 0.01 Rd 0.1 0.01 Rh2 (s) 0.005 - Rc 0.01 -

Freeze-drying process, low-temperature extraction process, low-temperature vacuum extraction process Gin Senocide  Extraction comparison

Step a:

Freezing temperature: -50 ^o C

Freeze-drying time: 24 hours

Step b:

Low Temperature Extraction Temperature: 60 ^o C

Low temperature extraction time: 8 hours

Step c:

Low temperature Vacuum temperature: 70 ^o C

Low temperature vacuum extraction time: 24 hours

Vacuum condition: 10 ^-2 torr

Solvent: distilled water

Extraction capacity: 500g / 20L

Gin Senocide Extraction (%) Atmospheric pressure extraction process (100 ^o C)
Production Yangsan gam 500g use Freeze drying process / low temperature extraction / low temperature vacuum extraction process (70 ^o C)
Freeze-dried goat 500 g ginseng Rg1 0.86 3.1 Re 1.12 3.2 Rb1 1.1 4.0 Rb2 - 0.2 Rg2 (s) - 0.05 Rg3 0.001 0.07 Rb3 1.1 3.3 Rh1 0.02 0.9 Rd 0.03 0.6 Rh2 (s) - 0.01 Rc 0.004 0.04

Freeze-drying process, low-temperature extraction process, low-temperature vacuum extraction process Gin Senocide  Comparison of extraction (freeze-dried goat 500 g ginseng)

Step a Freeze-drying process:

Freezing temperature: -50 ^o C

Freeze-drying time: 24 hours

b step low temperature extraction process:

Low Temperature Extraction Temperature: 60 ^o C

Low temperature extraction time: 8 hours

c stage low temperature vacuum extraction process:

Low temperature Vacuum temperature: 70 ^o C

Low temperature vacuum extraction time: 24 hours

Vacuum condition: 10 ^-2 torr

Solvent: methanol, ethanol, butanol, distilled water, mineral active water

Extraction capacity: 500g / 20L

Gin Senocide Extraction (%) Distilled water Methanol ethanol Butanol Mineral active water Rg1 3.1 3.3 3.3 3.7 5.1 Re 3.2 4.0 3.8 4.3 6.2 Rb1 4.0 3.9 4.4 5.1 7.3 Rb2 0.2 0.28 0.27 0.4 0.8 Rg2 (s) 0.05 0.053 0.051 0.06 0.15 Rg3 0.07 0.07 0.08 0.1 0.24 Rb3 3.3 3.9 4.2 4.3 6.1 Rh1 0.9 1.0 1.2 1.0 2.0 Rd 0.6 0.9 0.83 0.9 1.8 Rh2 (s) 0.01 0.01 0.04 0.03 0.08 Rc 0.04 0.065 0.06 0.07 0.14

After the freeze-drying process (step (a)) After the low temperature extraction process (step 2 (b))  In the low-temperature vacuum extraction process (Step 3 (c)), distilled water and minerals Active water  When used Gin Senocide  Comparison of extraction volume

(Freeze-dried Goat ginseng  500g use)

Step a:

Freezing temperature: -50 ^o C

Freeze-drying time: 24 hours

Step b:

Low Temperature Extraction Temperature: 60 ^o C

Low temperature extraction time: 8 hours

Step c:

Low temperature Vacuum temperature: 70 ^o C

Low temperature vacuum extraction time: 24 hours

Vacuum condition: 10 ^-2 torr

Solvent: Mineral active water

Extraction capacity: 500g / 20L

Gin Senocide Extraction (%) Distilled water Mineral active water Rg1 3.1 5.1 Re 3.2 6.2 Rb1 4.0 7.3 Rb2 0.2 0.8 Rg2 (s) 0.05 0.15 Rg3 0.07 0.24 Rb3 3.3 6.1 Rh1 0.9 2.0 Rd 0.6 1.8 Rh2 (s) 0.01 0.08 Rc 0.04 0.14

After the freeze-drying process (step a)  In the case of using distilled water under the low-temperature vacuum extraction step (step c) Gin Senocide  Comparison of extraction volume

Step a:

Freezing temperature: -50 ^o C

Freeze-drying time: 24 hours

Step c:

Low temperature Vacuum temperature: 70 ^o C

Low temperature vacuum extraction time: 24 hours

Vacuum condition: 10 ^-2 torr

Solvent: distilled water

Extraction capacity: 500G / 20L

Gin Senocide Extraction (%) Atmospheric pressure extraction process (100 ^o C)
Production Yangsan gam 500g use Freeze-drying / low-temperature vacuum extraction (70 ^o C)
Freeze-dried goat 500 g ginseng Rg1 0.86 2.1 Re 1.12 1.9 Rb1 1.1 2.2 Rb2 - 0.1 Rg2 (s) - - Rg3 0.001 0.02 Rb3 1.1 1.8 Rh1 0.02 0.2 Rd 0.03 0.2 Rh2 (s) - - Rc 0.004 0.01

Graph comparing the amount of ginsenoside extracted from ginseng with ginseng by using freeze-drying process, low-temperature extraction process and low-temperature vacuum extraction process using distilled water and mineral active water

a step of freeze drying step b, a step of low temperature extraction step c, a step of low temperature vacuum extraction step d, a cooling step e,

Claims (6)

Characterized in that the ginsenoside is extracted from the ginseng by the low temperature vacuum extraction process of the freeze-dried ginseng ginseng by using the mineral active water as a solvent. The maximum content of ginsenoside Extraction method. The method according to claim 1, wherein the lyophilized goat ginseng is further subjected to a low-temperature extraction process with mineral active water, followed by a low-temperature vacuum extraction process. The method according to claim 1 or 2, wherein the lyophilization process for obtaining freeze-dried ginseng is performed at 50 ° C. to -40 ° C. for 12 to 24 hours. The maximum content ginsenoside extraction method . Process according to claim 1 or 2, characterized in that the low-temperature vacuum extraction step of obtaining the lyophilized goat ginseng is carried out at 50 ° C to 90 ° C for 8 to 24 hours at 10 ^-1 to 10 ^-5 Torr. Maximum content of ginsenoside extract from goat ginseng. 3. The mineral activated water according to claim 1 or 2, characterized in that the mineral activated water distilled from the sea water springs is a mineral active water distilled from a seawater springs water jetted from the Kwangmodo dragon hot spring of Gwangmodo Gyeonggi Province to a mechanical vapor recompressor (MVR) The maximum content ginsenoside extraction method from the wilted goat ginseng. A ginsenoside extracted according to claim 1 or 2.

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