KR20150071842A - an extract composition enhancing the function of both the enzymes of alcohol decomposition and the enzymes of liver - Google Patents

Abstract

The present invention relates to a composition facilitating alcohol catabolic enzyme and liver enzymes activation after drinking using environmentally-friendly natural materials, and more specifically, to a composition facilitating alcohol catabolic enzyme (ALDH) and liver enzymes activation after drinking, which is composed by mixing red ginseng extract, natural plant extract, mixed fruit concentrates, and honey. Provided is the composition facilitating the ALDH and the liver enzymes activation, which is composed of, with respect to 100 parts by weight of red ginseng concentrate, 800-1200 parts by weight of natural plant concentrate, 700-900 parts by weight of mixed fruit concentrate, and 60-80 parts by weight of honey. The natural plant concentrate is composed of, with respect to 100 parts by weight of arrowroot extract, 40 to 60 parts by weight of Atractylodes macrocephala Koidzumi extract, 50 to 70 parts by weight of Hovenia dulcis nut extract, 40 to 60 parts by weight of licorice extract, 15 to 30 parts by weight of buckwheat extract, and 10 to 25 parts by weight of Artemisia capillaris Thunb. extract. The mixed fruit concentrate is composed of, with respect to 100 parts by weight of persimmon extract, 70 to 100 parts by weight of pear extract, 60 to 85 parts by weight of apple extract, 5-15 parts by weight of bean sprouts extract, and 3-10 parts by weight of ginger extract.

Description

[0001] The present invention relates to a method for promoting the activation of alcoholic enzymes and liver enzymes after drinking,

The present invention relates to a composition for promoting the activation of alcoholic enzymes and liver function enzymes after drinking with an eco-friendly natural material. More specifically, the present invention relates to a composition for promoting the activation of alcoholic enzymes and liver function enzymes by drinking alcoholic degradation enzymes And to a composition for promoting liver function enzyme activation.

The drinking culture that has been steadily continuing for a long time regardless of the east and the west is becoming deeply rooted in everyday life. Especially, many people who live in modern life unlike the past are stressed by various complex work and life

It is the present situation.

Therefore, since it is almost impossible to take the stress out of living in the modern life, it is almost impossible to get rid of the stress or the stress to be received by various hobbies, sports, smoking, drinking and the like suited to each individual's taste.

As more and more stress and mental and physical stresses become more and more common as more and more drinks and entertaining in busy work are increasingly complicated and diverse in today's business, it is necessary to drink alcohol that can be enjoyed without being admitted to separate time and place. I grabbed it.

Drinking is becoming a necessity in terms of relieving stress, and a lot of drinking (overeating) state becomes a succession, and the side effect of heavy drinking is heavy and sore, and a hangover, such as a thirst, Suffer from a phenomenon

.

This hangover is caused by the action of toxins such as ethanol or acetaldehyde accumulated in the hepatocytes. These substances accumulate in the hepatocytes for a long period of time, and the toxin activity continues, and fatigue, abdominal bloating, Vomiting, etc.

.

In other words, the normal ethyl alcohol metabolism process is that the alcohol introduced into the body is absorbed from the stomach or small intestine, and is transferred into the blood vessels and transferred to the liver.

In this case, liver hepatocytes of the liver have an alcohol dehydrogenase (ADH, alcohol dehydrogenase) to oxidize the alcohol to acetaldehyde. The acetaldehyde is decomposed into acetic acid by acetaldehyde alcohol dehydrogenase in hepatocytes, And then it is finally decomposed into carbon dioxide and water.

The acetaldehyde alcohol dehydrogenase also has an aldehyde dehydrogenase I type which initiates oxidation even when acetaldehyde is low in concentration and an aldehyde dehydrogenase II type which does not have a high concentration of acetaldehyde and does not act, The aldehyde dehydrogena is type II and because the acetaldehyde enzyme is deficient or deficient, the oxidation of acetaldehyde is slow, and therefore, the toxic action of acetaldehyde and ethyl alcohol which are not oxidized causes redness of face or body, Acetaldehyde syndrome, which is a headache phenomenon, interferes with normal metabolism and causes various hangover phenomena.

On the other hand, ethanol, which is the main component of alcohol, is absorbed through the small intestine and digestive tract, reaching its highest blood level within 20 to 120 minutes after ingestion, and the absorbed ethanol is metabolized in all organs including liver, , Excreted by urine, sweat

The remainder is degraded in the liver.

The ethanol degradation in the liver is the main metabolism through the oxidation reaction to acetaldehyde. It is known that this is caused by three reactive enzyme systems such as alcohol dihydrogenase, microsom ethanol oxidizing system (MEOS) and catalase.

However, the reason why ethanol causes harm to the liver is that alcohol dehydrogenase transforms ethanol into acetaldehyde. When NADH is produced using NAD, it affects the metabolism of other substances, thereby lowering fatty acid metabolism, Accumulated in

This is fatty liver.

The acetaldehyde causes a hypoxic state due to an obstruction of cellular organelles such as mitochondria in hepatocytes and an increase in metabolism of alcohol, and the alcohol itself causes cell membrane failure of hepatocytes, resulting in general boredom, fatigue, amnesia, abdominal bloating, And suffer from pain due to hangover symptoms such as indigestion, vomiting, diarrhea, and the like.

Therefore, studies have been actively conducted to remove hangover caused by acetaldehyde oxidized during the alcohol consumption and to reduce blood alcohol concentration. As a result, studies on dementia, hepatic detoxification, hepatic blood flow improvement, fat absorption Cholinic acid, which has the action of excretion of waste through fine biliary tree, or urusho dexycinic acid which is effective for the liver function improvement of chronic liver disease, taurosuideoxycolic acid which is effective for the treatment of fatty liver, Chenodeoxycholic acid, dihydrocholic acid, and the like.

In addition, there are many herbal medicines based on Ganoderma lucidum, ginseng as a main ingredient, a plant extract based on bean sprouts, soybean extract, and a drink using herbal medicine. However, Because it is a complex manifestation, it is not influenced simply by the alcohol concentration in the blood, so much research and efforts are urgently required.

In view of the above circumstances, the present invention provides a composition for prevention and removal of hangover, hereinafter referred to as " Prior Art 1 ", which includes at least one herbal medicine extract selected from the group consisting of: One or more herbal medicine extracts selected from the group consisting of one or more herbal medicine extracts selected from the group consisting of marigolds and milk seeds and one or more herbal medicine extracts selected from the group consisting of nettle, Herbal composition composition by natural plants ".

In addition, the present applicant has proposed a method of extracting a water extract of red ginseng concentrate of alcoholic extract of red ginseng, pear, apple, quince, citron and mango in the patent document 10-2013-0063162 (beverage composition for hangover elimination, And a fruit-mixed concentrate obtained by concentrating the fruit juice concentrate.

The present invention is an extension of Applicant's prior art of the present applicant as described above to further improve the prior art of the applicant to provide a composition that promotes alcoholysis after drinking and significantly increases hepatic enzymatic activity do.

Further, the prior art described above is more effective as a herbal composition composition than the prior art, but still has a problem that the alcohololytic enzyme promoting action and the hepatic functional enzyme activating action are inferior after drinking, and a composition for solving the problem is provided.

The present invention also provides a composition for promoting the activation of alcoholic enzymes and liver enzymes after drinking with eco-friendly natural materials, which exerts an excellent effect for relieving headaches and nausea after drinking.

In order to solve the above-mentioned needs and problems,

(ALDH) and liver function enzyme activation by mixing alcoholic beverages, red ginseng concentrate, natural plant concentrate, fruit mixed concentrate, and honey.

(ALDH), which is characterized in that 800 to 1200 parts by weight of a natural plant concentrate, 700 to 900 parts by weight of a fruit mixed concentrate and 60 to 80 parts by weight of honey are mixed with 100 parts by weight of a red ginseng concentrate, Lt; / RTI >

40 to 60 parts by weight of the extract, 50 to 70 parts by weight of the extract of Hovenia dulcis, 40 to 60 parts by weight of the licorice extract, 15 to 30 parts by weight of the buckwheat extract, 10 to 30 parts by weight of the extract of Artemisia princeps To 25 parts by weight of an alcohol degrading enzyme (ALDH), which is characterized in that it is prepared by mixing.

The fruit mixed concentrate is prepared by mixing 70 to 100 parts by weight of a pear extract, 60 to 85 parts by weight of an apple extract, 5 to 15 parts by weight of a bean sprouts extract and 3 to 10 parts by weight of a ginger extract with 100 parts by weight of a sweet persimmon extract (ALDH) and a composition for promoting liver function enzyme activation.

The composition according to the present invention has remarkably large effect of promoting alcoholysis and liver function enzyme activation after drinking as compared with conventional prior arts.

Also, the composition according to the present invention has a higher stability than the prior art.

In addition, the composition according to the present invention has an effect of exerting an excellent effect on the relief of headache and nausea after drinking as compared with the prior arts.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a graph showing the concentration of ethanol in an animal experiment of a composition according to the present invention. FIG.
FIG. 2 is a graph showing changes in ALT concentration in serum for an animal experiment of a composition according to the present invention. FIG.
FIG. 3 is a graph showing changes in serum AST concentration in an animal experiment of a composition according to the present invention. FIG.
FIG. 4 is a graph showing changes in serum ADH concentration in an animal experiment of the composition according to the present invention. FIG.
Figure 5 is a graph showing changes in ALDH concentration in serum for animal experiments of the composition according to the present invention.

BRIEF DESCRIPTION OF THE DRAWINGS FIG.

The present invention provides a composition for accelerating the activation of alcoholic digestive enzymes (ALDH) and hepatic enzymes after drinking alcohol mixed with red ginseng concentrate, natural plant concentrate, fruit mixed concentrate, and honey.

More specifically, the present invention comprises 800 to 1200 parts by weight of a natural plant concentrate, 700 to 900 parts by weight of a fruit mixed concentrate, and 60 to 80 parts by weight of honey, in 100 parts by weight of a red ginseng concentrate.

The above red ginseng concentrate of the present invention has a technical feature in its production method.

The red ginseng concentrate of the present invention is prepared by the following method.

① Rinsing and selection process: Raw ginseng for 4 years or more purchased is washed with purified water several times using a washing machine to prevent foreign matter.

② Steaming process: The washed raw ginseng is firstly boiled at 50-70 ° C for 30-60 minutes and then further boiled for 2-3 hours at 90 ° C or lower.

③ Drying process: The dried raw material is dried in a hot air dryer at 50 ~ 70 ℃ for 24 ~ 48 hours to prepare red ginseng with a moisture content of 14% or less.

(4) Extraction process: The above-prepared red ginseng is put into an extractor and extracted continuously for 3 to 5 times by extracting the extract at a temperature of 70 to 75 ° C for 24 hours using a solvent (97%) equivalent to 4 to 7 times of the amount of red ginseng Thereby obtaining a red ginseng extract.

(5) Filtration process: The extracted red ginseng extract is filtered using a filtration filter (1 to 20 탆).

⑥ Concentration Process: The filtered red ginseng extract is transferred to a concentrator and concentrated under reduced pressure at a temperature of 40-50 ° C and 700-750 mmHg for about 3-4 hours to prepare a red ginseng concentrate having a solid content of 60% or more.

⑦ Aging process: The above red ginseng concentrate is inoculated with enzyme at 60 캜 or less, stirred for about 3 hours, and allowed to stand for about 20 to 28 hours.

Red ginseng concentrate is prepared through enzyme inactivation and post-sterilization at a temperature of above 85 캜.

The above-mentioned natural plant concentrate of the present invention has a technical characteristic in its production method and is manufactured by the following method.

The natural plant concentrate according to the present invention is prepared by mixing extracts of Phellinus linteus, Lycoris spp., Hovenia dulcis, Licorice, Buckwheat and Artemisia.

In the natural plant concentrate of the present invention, 40 to 60 parts by weight of an extract, 50 to 70 parts by weight of a Houttuynia cordata extract, 40 to 60 parts by weight of a licorice extract, 15 to 30 parts by weight of a buckwheat extract, 10 to 25 parts by weight.

In the present invention, Pueraria means root.

Korea and Japan use the roots of Pueraria lobata (Willd.) Ohwi and the roots of Pueraria lobata (Willd.) Ohwi and Pueraria thomsonii Benth. use.

Changgeun sweat, fever, fever, healing headache and stop the thirst. It is used for digestion, headache, anemia, dysentery, abdominal pain, dryness, cold, vomiting and bleeding of wife. It blooms raw roots and sucks and drinks.

The fruit of the 칡 is called the gag, and it is effective in the diarrhea. The 칡 flower which is a 칡 flower has a unique sweetness, and it releases the digestion and strengthens the intestines. 칡 powder is called galmium to stop the thirst, to see the feces and to see the children, fever is sick and the end is burning. Diabetes, dysentery, colitis, and malignant tumors.

The extract of the present invention is a dried medicament (Korea) by removing the roots or juniors of Atractylodes japonica Koidzumi or Atractylodes macrocephala Koidzumi. In China, only Atractylodes macrocephala Koidzumi (白 朮) Atractylodes japonica Koidzumi and Atractylodes ovata are used.

It is weak in the function of 脾 胃 (脾胃), news, mala appearance, yellow color of the face is diluted, the diarrhea is good, and the water is stagnant, the whole body is swollen, helps digestion of water when not digested. It can also be used for chest leaks, coughs and clear sputum caused by accumulation of water and wetness in the spleen. It is also used for the vomiting of pregnancy and sweating on the skin due to fragility. do. It is also used for colds and limb pain with gastrointestinal disorders.

Pharmacological increase of mice weight gain and endurance, increase phagocytic ability, promotion of cell immune function was reported. In addition, intestinal (intestinal) inhibition and control of excitement, anti-ulcer and liver function protection, immune function hyperactivity, vasodilation, diuretic and hypoglycemic action, anti-cancer action has been reported.

The Hovenia dulcis according to the present invention means fruit of Hovenia dulcis.

The hinoki is 10m high and the bark is blackish gray, cracked vertically and peeled off. Leaves are alternate, wide ovate or elliptical shape, with an edge mount. The front face of the leaf is green and has no hairs. The back side is light green and has no hairs on the veins. Fruits ripen from September to October, rounded and brownish. It is a deciduous broad-leaved arboreous tree and its origin is Korea and distributed throughout the country.

The licorice of the present invention is called ural licorice and curly licorice, and it grows in Russia (Siberia), Iran, Afghanistan, Pakistan, China (Gansuk province, Shin Kangsung), Mongolia and cultivated in Korea.

In Korea and Japan, roots and stem parts of licorice (Glycyrrhiza uralensis Fischer), European licorice (Glycyrrhiza glabra L.) or other plants are peeled or peeled. In China, dried roots of licorice (Glycyrrhiza uralensis Fischer: licorice), licorice (Glycyrrhiza glabra L .: light 果 licorice), licorice (Glycyrrhiza inflata Batal: 果 甘草) are used.

The buckwheat of the present invention is a plant belonging to the genus Pseudomonas spp. It is also called mamil and megumi.

Buckwheat has a high nutritional value due to its high protein content, and it has a unique taste and is widely used for noodles, noodles, mushrooms and buns. Especially, in Gangwon Province, Hamgyeong Province and Pyeongando Province where buckwheat is produced in large quantities, buckwheat noodles and cold noodles made of buckwheat have developed into native foods. The young leaf is used as a vegetable, and the footbed is excellent as a green tea.

Pillows made of buckwheat pods are light, unbroken, well-ventilated and cool and damp, so they have a reputation for cooling the heat and eliminating the wind.

In leaves and flowers, the blood pressure lowering agent is extracted. Because buckwheat flowers are bloomed for a considerable period of time and there are many honey gums, the production of honey is many. Buckwheat honey is dark brown, has a distinctive smell and is good for medicine.

Artemisia capillaris Thunb. Is a medicinal plant which dried above the ground (Korea), Japan uses a spatula of Japanese apricot, and China uses A. capillaris Thunb. And Artemisia scoparia Waldst. et Kit: 濱 蒿) is used on the ground. A. iwayomogi is used in Korea as Han-In-Jin

In the natural plant concentrate of the present invention, 40 to 60 parts by weight of an extract, 50 to 70 parts by weight of a Houttuynia cordata extract, 40 to 60 parts by weight of a licorice extract, 15 to 30 parts by weight of a buckwheat extract, 10 to 25 parts by weight.

In the present invention, the natural plant concentrate may be prepared by separately extracting each raw material with the above-mentioned weight, or by mixing all the raw materials with the above-mentioned weight.

Therefore, a method of immersing the above raw material, which is a usual extraction method, in water and heating it to obtain an extract can be used.

In addition, in the present invention, the raw material is washed well in distilled water flowing in order to obtain a higher concentration of the extract, filled with distilled water of the same volume, and extracted with hot water using a reaction electric heater.

The filtrate was filtered using 0.45 μm and 0.1 μm filter paper continuously, and the inorganic salts in the filtrate were removed by precipitation with pharmacopoeial salt, adjusted to pH 7.3 with citric acid and Na 3 PO 4, Can be used.

The present invention also has technical features in producing the above-mentioned natural plant concentrate.

(1) According to the present invention, the above-mentioned extracts of Puerariae radix, Bacillus sp., Hovenia dulcis, Licorice, Buckwheat and Artemisia are collected in weight units of the above extract.

② Selection of raw materials and washing process - The above materials are selected and washed several times.

③ Extraction process - The above raw materials and purified water are added to the extractor, and they are extracted under reduced pressure at 75 ~ 80 ℃ for 7 ~ 9 hours. Thereafter, it is circulated under reduced pressure at 65 to 75 ° C for about 7 to 9 hours.

Then, the mixture is reheated at 75 to 80 ° C for 2 to 3 hours, and then the reduced-pressure recirculated mixture is extracted at 65 to 75 ° C for 8 to 9 hours to obtain an extract.

④ Enzyme treatment process - If the temperature of the extract extracted from the extraction process in the above ③ is less than 60 ℃, the enzyme is inoculated and allowed to stand for 3 hours and then heated to 96 ℃ to inactivate the enzyme.

(5) Political Process - The extract of the enzyme treatment in (4) above is allowed to stand at 40 DEG C or lower for 7 to 9 hours.

(6) Concentration process - Only the supernatant of the above (5) is transferred to a concentrator and concentrated under reduced pressure at 60-70 ° C and 700-750 mmHg for about 5-6 hours to prepare a natural plant concentrate having a solid content of 30% or more.

The present invention relates to a method for producing a fruit mixed concentrate, which has technical features and is produced by the following method.

The fruit mixed concentrate of the present invention is prepared by mixing sweet persimmon, pear, apple, bean sprouts and ginger extract.

The fruit mixed concentrate of the present invention is prepared by mixing 70 to 100 parts by weight of a pear extract, 60 to 85 parts by weight of an apple extract, 5 to 15 parts by weight of a bean sprouts extract and 3 to 10 parts by weight of a ginger extract with 100 parts by weight of a sweet persimmon extract.

As described above, the present invention is applicable to a method of mixing the above-mentioned raw materials by separately extracting the respective raw materials, or by mixing all of the raw materials with the above-mentioned weight parts in preparing the above-mentioned fruit mixed concentrate.

The sweet persimmon of the present invention is a generic term for a tannin component, which is the content of the pulp, becoming insoluble and producing a sweet taste.

The vessel of the present invention refers to a conventional vessel.

The apple of the present invention also means a conventional apple.

The bean sprouts of the present invention means ordinary bean sprouts.

The ginger of the present invention refers to a perennial plant with ginger root, ginger root, ginger root, and root.

The present invention has technical features in producing the above-mentioned fruit mixed concentrate and is manufactured by the following method.

① Prepare raw materials such as persimmon leaves, pears, apples, bean sprouts and ginger as weight of the above extract.

② Washing and cutting process - Select the sweet persimmon, pear, apple, ginger and bean sprouts prepared in the above, then wash several times and cut.

③ Ginger Extract Manufacturing Process - Ginger is put into purified water of 4 ~ 6 times of whole raw materials, extracted at 85 ~ 95 ℃ for 2 ~ 3 hours and circulated for 8 hours.

④ Total Extraction Process - The ginger extract of ③ above is added with persimmon, pear, apple, and bean sprouts, and the mixture is vacuum-extracted at 70 to 75 ° C for 8 hours and then under reduced pressure at 65 to 75 ° C for about 0.5 to 1.5 days.

(5) Filtration process - The extract of the whole extraction process of the above (4) is filtered using a filtration filter (3 to 10 μm)

⑥ Concentration Process - The filtered fruit mixed extract solution is transferred to a concentrator and concentrated under reduced pressure at 700-750 mmHg at 65 ° C for about 3-4 hours to prepare a fruit mixed concentrate having a solid content of 60% or more.

⑦ Aging process - The concentrate of ⑥ is transferred to the aging machine and aged at 55 ~ 60 ℃ for about 45 ~ 52 hours.

A fruit mixed concentrate is prepared by the above process.

The present invention has a technical feature in a method of preparing a composition by mixing the red ginseng concentrate, the natural plant concentrate, the fruit mixture concentrate, and the honey prepared as described above.

In the present invention, 800 to 1200 parts by weight of a natural plant concentrate, 700 to 900 parts by weight of a fruit mixture concentrate and 60 to 80 parts by weight of honey are mixed with 100 parts by weight of a red ginseng concentrate, stirred and mixed at 70 to 80 ° C for 20 to 40 minutes The mixing process is carried out.

The present invention relates to a composition for promoting alcoholysis (ALDH) and hepatic enzymatic activation after drinking by carrying out an aging process in which the mixture is transferred to an aging machine and aged at 55 to 60 ° C for agitation for 40 to 55 hours.

The above aged composition is filled in a sterilized closed container and stored at 5 ° C or lower.

The present invention has shown that the composition prepared by the above method has an effect of promoting the activation of alcoholic enzymes and hepatic functional enzymes after drinking as described below through animal experiments.

<Examples>

100 g of the red ginseng concentrate, 1030 g of the natural plant concentrate, 800 g of the fruit mixture concentrate, and 70 g of honey are mixed, and the mixture is stirred and mixed at 75 캜 for 30 minutes.

After the above mixing process, the mixture is transferred to an aging machine and aged at 55 to 60 ° C for aging for aging for 40 to 55 hours to perform a composition (in the animal experiment below, "Miracle TY (health drink)").

Ⅰ. Animal test method

Male Sprague-Dquley 6-week-old rats (180-200 g) purchased from Orient Bio Inc. (Seongnam, Korea) were used as experimental animals. It is adapted for one week under constant condition in constant temperature and humidity and air cleaning system and used in the experiment. In order to induce acute poisoning of alcohol, 40% of alcohol was administered by oral route to the level of 5g per kg of body weight by the method of kato et al. The experiment was carried out.

The experimental group was divided into two groups, control group and administration group, and fasted for 18 hours before oral administration of alcohol. The test group was divided into alcohol-treated group, healthy drink group (Miracle TY), and third-party product group (Callose). One hour before oral administration of alcohol, 1 ml / kg of saline was administered to the alcohol control group, Was administered orally at a dose of 1 ml / kg.

To measure the changes in plasma enzyme concentration over time, the blood collected from the femoral blood vessels was centrifuged at 3000 rpm for 20 minutes and analyzed for the concentration of the enzyme in blood after 3 or 5 hours of oral administration. All of these procedures were carried out after obtaining the approval of Daejeon University Animal Experimental Ethics Committee (DJUARB2013-005).

Ⅱ. Experiment result

1. Changes in Blood Ethanol Concentration

There was no change in blood alcohol concentration according to the change of time with 6.17 ± 2.30 nmol / ul at 3 hours after alcohol administration and 5.76 ± 3.23 nmol / ul after 5 hours in alcohol control group. However, in the case of Miracle TY group, , Respectively. In the case of Miracle TY treated group, 2.79 ± 0.21 nmol / ul after 3 hours and 2.21 ± 0.11 nmol / ul after 5 hours, ethanol concentration decreased rapidly with time (Fig. 1)

2. Serum  Concentration change of liver function indicator enzyme

To investigate the effect of hangover remedy on alcohol in the liver function of the human body, we measured the change of ALT and AST activity in serum used as an index to evaluate liver damage.

2-1 ALT concentration change

In comparison with the alcohol control group of 6.56 ± 1.13 mU / ml, in the case of the Miracle TY treated group, 6.13 ± 1.67 mU / ml after 3 hours and 6.11 ± 1.50 mU / ml after 5 hours (Fig. 2)

2-2 AST concentration change

The activity of AST was 32.97 ± 5.82 mU / ml after 3 hours in the alcohol control group, 24.25 ± 3.05 mU / ml after 5 hours in the alcohol control group, 31.47 ± 3.47 mU / ml after 3 hours in the group treated with Miracle TY, 30.86 ± 8.38 mU / ml and showed similar results at all times (Figure 3)

It was shown that the consumption of Miracle TY did not affect the normal liver function as compared with the other product (callus) treated group, and these results prove that the effect as a hangover remedy is remarkable.

3. Serum  Alcohol Metabolic enzyme system  Effect on activity

3-1 Serum ADH Activity change

The activity of ADH was 3.75 ± 0.74 mU / ml after 3 hours and 3.76 ± 0.74 mU / ml after 3 hours in the alcohol control group, and 1.24 ± 0.12 mU / ml after 3 hours in the group treated with Miracle TY 1.17 ± 0.52 mU / ml, indicating that the enzyme activity was rapidly reduced at all times (FIG. 4).

3-2 Serum ALDH Activity change

The activity of ALDH was 3.73 ± 1.01 mU / ml after 3 hours and 4.73 ± 2.75 mU / ml after 3 hours in the alcohol control group. In the group treated with Miracle TY, it was 2.08 ± 1.00 mU / ml after 3 hours and 5 hours 0.75 ± 0.76 mU / ml, and the enzyme activity was rapidly reduced at all times (FIG. 5).

It is thought that the change in blood concentration after ingestion of orally administered alcohol is reduced by lowering the absorption rate through the gastrointestinal tract or by increasing the alcohol metabolism,

As a result of the above experiment, it is confirmed that Miracle TY, which is a composition of the present invention, acts to reduce alcohol in the blood by inhibiting absorption through digestive organs.

The present invention provides a composition for promoting alcoholysis and hepatic functional enzyme activation after drinking as shown in the above experimental results.

The present invention is very useful for industries that produce, manufacture, sell, distribute and research functional foods.

In addition, the present invention is particularly useful for an industry that produces, manufactures, sells, distributes and studies hangover relief and liver function activating compositions.

Claims (4)

(ALDH) and liver function enzyme activation by mixing red ginseng concentrate, natural plant concentrate, fruit mixed concentrate, and honey.
The method according to claim 1,
(ALDH), which is characterized in that 800 to 1200 parts by weight of a natural plant concentrate, 700 to 900 parts by weight of a fruit mixed concentrate and 60 to 80 parts by weight of honey are mixed with 100 parts by weight of a red ginseng concentrate, .
3. The method according to claim 1 or 2,
The natural plant concentrate is prepared by mixing 40 to 60 parts by weight of an extract, 50 to 70 parts by weight of a Houttuynia cordata extract, 40 to 60 parts by weight of a licorice extract, 15 to 30 parts by weight of a buckwheat extract, (ALDH) and a composition for promoting hepatic enzyme activation.
3. The method according to claim 1 or 2,
The fruit mixed concentrate is prepared by mixing 70 to 100 parts by weight of a pear extract, 60 to 85 parts by weight of an apple extract, 5 to 15 parts by weight of a bean sprouts extract and 3 to 10 parts by weight of a ginger extract with 100 parts by weight of a sweet persimmon extract (ALDH) and a composition for promoting hepatic enzyme activation.

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