KR20150061634A - X선 조영제인 아이오포르미놀의 제조법 - Google Patents

X선 조영제인 아이오포르미놀의 제조법 Download PDF

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Publication number
KR20150061634A
KR20150061634A KR1020157007423A KR20157007423A KR20150061634A KR 20150061634 A KR20150061634 A KR 20150061634A KR 1020157007423 A KR1020157007423 A KR 1020157007423A KR 20157007423 A KR20157007423 A KR 20157007423A KR 20150061634 A KR20150061634 A KR 20150061634A
Authority
KR
South Korea
Prior art keywords
compound
bis
preparation
water
contrast agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020157007423A
Other languages
English (en)
Korean (ko)
Inventor
미켈 타닝
안드레아스 올슨
크리스티안 글뢰가르트
Original Assignee
지이 헬스케어 에이에스
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 지이 헬스케어 에이에스 filed Critical 지이 헬스케어 에이에스
Publication of KR20150061634A publication Critical patent/KR20150061634A/ko
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020157007423A 2012-09-27 2013-09-17 X선 조영제인 아이오포르미놀의 제조법 Ceased KR20150061634A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO20121103 2012-09-27
NO20121103 2012-09-27
PCT/US2013/060092 WO2014052092A1 (en) 2012-09-27 2013-09-17 Preparation of ioforminol, an x-ray contrast agent

Publications (1)

Publication Number Publication Date
KR20150061634A true KR20150061634A (ko) 2015-06-04

Family

ID=49237721

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020157007423A Ceased KR20150061634A (ko) 2012-09-27 2013-09-17 X선 조영제인 아이오포르미놀의 제조법

Country Status (12)

Country Link
US (1) US9827334B2 (https=)
EP (1) EP2900631B1 (https=)
JP (1) JP6325547B2 (https=)
KR (1) KR20150061634A (https=)
AU (1) AU2013323982B2 (https=)
BR (1) BR112015004580A2 (https=)
CA (1) CA2881853A1 (https=)
ES (1) ES2702275T3 (https=)
IN (1) IN2015DN01186A (https=)
MX (1) MX365249B (https=)
RU (1) RU2642436C2 (https=)
WO (1) WO2014052092A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX354604B (es) * 2012-09-27 2018-03-07 Ge Healthcare As Preparacion de un compuesto intermediario de ioforminol.
AU2013323982B2 (en) 2012-09-27 2017-11-23 Ge Healthcare As Preparation of Ioforminol, an X-ray contrast agent
EP3393383A4 (en) * 2015-12-23 2019-07-31 Rhode Island Hospital HEAT ACCELERATOR COMPOSITIONS AND METHODS OF USE

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698739A (en) * 1989-07-05 1997-12-16 Schering Aktiengesellschaft Carboxamide non-ionic contrast media
IL94718A (en) 1989-07-05 1994-10-21 Schering Ag Carboxamide non-ionic contrast media and method for the preparation thereof
NO20043305D0 (no) 2004-08-09 2004-08-09 Amersham Health As Preparation of lodixanol
WO2007055580A1 (en) 2005-11-10 2007-05-18 Ge Healthcare As Contrast agents and diagnostic compositions based on iodine-containing cyanuric acid derivatives
BRPI0814811A2 (pt) * 2007-07-12 2015-02-03 Ge Healthcare As Composto, agente, método, e composição de diagnóstico, uso de um composto, e, método de formação de imagem
BR112012033776A2 (pt) 2010-07-12 2016-11-01 Ge Healthcare As composição,e, método de exame de raios-x.
CN102816085B (zh) 2012-08-20 2013-08-14 浙江司太立制药股份有限公司 碘海醇杂质的制备方法
AU2013323982B2 (en) 2012-09-27 2017-11-23 Ge Healthcare As Preparation of Ioforminol, an X-ray contrast agent

Also Published As

Publication number Publication date
AU2013323982B2 (en) 2017-11-23
US20150265727A1 (en) 2015-09-24
ES2702275T3 (es) 2019-02-28
RU2642436C2 (ru) 2018-01-25
US9827334B2 (en) 2017-11-28
JP6325547B2 (ja) 2018-05-16
WO2014052092A1 (en) 2014-04-03
RU2015107017A (ru) 2016-11-20
AU2013323982A1 (en) 2015-03-05
CN104661995A (zh) 2015-05-27
EP2900631A1 (en) 2015-08-05
MX365249B (es) 2019-05-28
IN2015DN01186A (https=) 2015-06-26
MX2015003913A (es) 2015-08-05
BR112015004580A2 (pt) 2017-07-04
CA2881853A1 (en) 2014-04-03
EP2900631B1 (en) 2018-11-14
JP2015530415A (ja) 2015-10-15

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EP1989179A1 (en) Contrast agents
EP2900631B1 (en) Preparation of ioforminol, an x-ray contrast agent
JP5248330B2 (ja) 造影剤
US9884808B2 (en) Preparation of an intermediate compound of ioforminol
CN104661995B (zh) X-射线造影剂ioforminol的制备
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US20080267884A1 (en) Contrast Agents and Diagnostic Compositions Based on Iodine-Containing Cyanuric Acid Derivatives
Wynn et al. Priebe et al.

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PA0105 International application

Patent event date: 20150324

Patent event code: PA01051R01D

Comment text: International Patent Application

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Patent event code: PA02012R01D

Patent event date: 20180817

Comment text: Request for Examination of Application

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PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20200115

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20200327

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20200115

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I