KR20150030385A - Composition for improving sexual function - Google Patents

Abstract

The present invention provides a health food composition containing, as active ingredients, a red ginseng extract, octacosanol, a Schisandra chinensis extract, a Polygonum multiflorum extract, a Rubus coreanus extract, a maca extract, a leek extract, and a France pinaster bark. The health food composition of the present invention has excellent effects of rejuvenating the body and strengthening the male sexual function, and thus the health food composition of the present invention can be used as a composition for improve the male health or strengthening the male sexual function.

Description

Technical Field [0001] The present invention relates to a composition for improving male sexual function,

The present invention relates to a health food composition containing red ginseng extract, octacosanol, Omija extract, Sasuo extract, bokbunja extract, maca extract, leek extract and French shoreline bark extract.

Male sexual dysfunction can be classified into two groups: erectile dysfunction, sexual dysfunction, erectile dysfunction, and erectile dysfunction. Erectile dysfunction generally refers to erectile dysfunction, sexual dysfunctional erectile dysfunction, persistent and painful erectile dysfunction of the penis, and disruption of the spongy tissues and associated fascia of the penis. Erectile dysfunction is caused by psychologic impotence, organic impotence, or a combination of these two factors. This type of erectile dysfunction is classified as neurogenic, vascular, and endocrine erectile dysfunction. Decreased sexual function is closely related to the deterioration of vital function, and in severe cases, it can develop into chronic erectile dysfunction.

Sexual dysfunction is caused by various causes such as neurological and endocrinological factors as well as psychological reasons, so it can not be solved by a single-component medicine. In the case of drugs for sexual functioning internationally, animal experiments and clinical trials have been reported, but in some cases, sexual enhancement drugs are being used.

Accordingly, a natural substance extract is used to ameliorate male sexual dysfunction, and a sexual function improving agent of the conventional food concept is as follows. It has been disclosed that a composition for improving sexual dysfunction using an extract of Goatsam ginseng has an inhibitory activity against cGMP phosphodiesterase to improve sexual dysfunction such as erectile dysfunction or erectile dysfunction (Patent Document 1) A composition for preventing and treating sexual dysfunction including a goat's milk "(Patent Document 2) using a concentrated liquid and a fermented milk of goat milk has been filed.

Natural product extracts derived from various raw materials have been used as active ingredients of sexual function improvers, but mixtures containing all of red ginseng extract, octacosanol, omija extract, dassauo extract, bokbule extract, maca extract, leek extract and French coastal bark extract Has not yet been found to have the effect of improving the health and sexual performance of males,

Korean Patent Application No. 2002-0026650 Korean Patent Application No. 2000-0026442

It is an object of the present invention to provide a health food composition comprising red ginseng extract or the like as an active ingredient.

In order to solve the above problems, the present invention provides a health food composition containing red ginseng extract, octacosanol, omija extract, mushroom extract, bokbunja extract, maca extract, leek extract and French coastal bark extract as effective ingredients.

The health food composition of the present invention is superior to a known health food composition in that it exhibits the body and improves male sexual function. Therefore, the health food composition of the present invention can be used as a composition for improving male health or for improving male sexual function Can be used.

Fig. 1 is a graph showing the degree of sexual function improvement after taking the composition of Production Example 1. Fig.
FIG. 2 is a graph showing the degree of change in the number of times of sexual intercourse attempts and the duration of erection after taking the composition of Preparation Example 1. FIG.
FIG. 3 is a graph showing the results of an average difference test for comparison of sexual function changes before and after taking the composition of Production Example 1. FIG.
Fig. 4 is a chart showing changes in sexual desire impulse before and after taking the composition of Production Example 1. Fig.
FIG. 5 is a graph showing changes in the satisfaction level of sexual life after taking the composition of Preparation Example 1. FIG.

First, terms used in the specification of the present invention will be described.

The 'extract' referred to in the present invention refers to a substance extracted from raw materials by all known methods, and the extracted extract, the concentrate obtained therefrom, and the dried product of the concentrate obtained therefrom, It contains all of the excipients and powder.

The term 'juice solution' referred to in the present invention refers to a juice obtained by a conventional method known from the prior art. The juice thus obtained, the concentrate obtained therefrom, the dried product of the concentrate obtained therefrom, Powders or excipients into powder.

Hereinafter, the present invention will be described in detail.

The present invention provides a health food composition containing, as an active ingredient, red ginseng extract, octacosanol, Omija extract, Sucrose extract, bokbunja extract, maca extract, leek extract and French coastal bark extract.

The extract can be obtained from a raw material such as red ginseng, omija, huasuo and bokbun, or a dried product thereof, or a commercially available extract itself can be used directly. The raw material of the extract can be used without limitation such as cultivated or commercially available .

Of the extracts, the omija, the sewage, and the brambles can be individually extracted and used. Preferably, the extract can be extracted after mixing the three raw materials, but the present invention is not limited thereto.

Specifically, in the mixed extraction of Omija, Sasao and Bokbunja, the amount of Omija may be 10 to 70 parts by weight, preferably 20 to 60 parts by weight, more preferably 30 to 50 parts by weight, But it is not limited thereto.

In addition, at the time of mixed extraction of Omija, Sasao and Bokbunja, the sewage may be contained in 1 to 60 parts by weight, preferably 10 to 50 parts by weight, more preferably 20 to 40 parts by weight, But are not limited thereto.

In addition, the brambles may be contained in an amount of 1 to 60 parts by weight, preferably 10 to 50 parts by weight, and more preferably 20 to 40 parts by weight, based on 100 parts by weight of the total raw materials in the mixed extraction of omija, But are not limited thereto.

When the extract is obtained by extracting from the raw material, the extract can be prepared by a conventional extraction method known in the art such as a solvent extraction method, an ultrasonic extraction method, a filtration method and a reflux extraction method, preferably by a solvent extraction method or a reflux extraction method have. The extraction process can be repeated several times, and thereafter, a method such as concentration or drying can be additionally carried out. Concretely, the obtained extract is concentrated under reduced pressure to obtain a concentrated liquid, and the concentrated liquid can be dried as it is or dried using an appropriate amount of excipient, and then a concentrated powder can be prepared using a pulverizer.

The extract can be extracted with water, an organic solvent or a mixture thereof as an extraction solvent. The organic solvent may be any one selected from the group consisting of C ₁ -C ₄ alcohols, n-hexane, dichloromethane and ethyl acetate, or a mixed solvent thereof, but is not limited thereto. The C ₁ -C ₄ alcohol may be, but is not limited to, methanol, ethanol or butanol.

In one preferred embodiment, the extract is prepared by adding an extracting solvent having a volume of 2 to 200 times, preferably 10 to 30 times the volume of the raw material to a shredded raw material and heating at 10 to 100 ° C for 1 hour to 20 days, The concentrate can be prepared by extracting for 1 to 10 days, filtering and concentrating under reduced pressure, but is not limited thereto.

Meanwhile, the health food composition of the present invention may contain any amount (effective amount) of each extract, which is an effective ingredient thereof, as long as it can exhibit male sexual function improvement. A typical effective amount is an amount of 100 parts by weight By weight, and in the range of 0.001 to 99.900 parts by weight. Herein, "effective amount" refers to an amount of an effective ingredient capable of inducing prevention, amelioration, treatment, or delay in the expression of such symptoms. Such effective amounts can be determined experimentally within the ordinary skill of those skilled in the art.

Preferably, the red ginseng extract contained in the composition is contained in an amount of 0.001 to 99.9 parts by weight based on 100 parts by weight of the composition, more preferably in an amount of 10 to 90 parts by weight, more preferably in an amount of 40 to 60 parts by weight , But is not limited thereto.

The octacosanol contained in the composition may be contained in an amount of 0.001 to 99.9 parts by weight, preferably 0.1 to 20 parts by weight, more preferably 0.5 to 7 parts by weight, based on 100 parts by weight of the composition. But is not limited thereto.

The Omiza extract contained in the composition may be contained in an amount of 0.001 to 99.9 parts by weight based on 100 parts by weight of the composition, preferably in an amount of 0.1 to 20 parts by weight, more preferably 2 to 7 parts by weight More preferably, but not exclusively.

The Sucrose extract contained in the composition may be contained in an amount of 0.001 to 99.9 parts by weight based on 100 parts by weight of the composition, preferably in an amount of 0.1 to 20 parts by weight, and in an amount of 2 to 7 parts by weight More preferably, but not exclusively.

The brambone extract contained in the composition may be contained in an amount of 0.001 to 99.9 parts by weight, preferably 0.1 to 20 parts by weight, and more preferably 1 to 7 parts by weight, based on 100 parts by weight of the composition More preferably, but not exclusively.

The maca extract contained in the composition may be contained in an amount of 0.001 to 99.9 parts by weight based on 100 parts by weight of the composition, preferably in an amount of 1 to 40 parts by weight, more preferably 5 to 20 parts by weight More preferably, but not exclusively.

The leek extract contained in the composition may be contained in an amount of 0.001 to 99.9 parts by weight based on 100 parts by weight of the composition, preferably in an amount of 1 to 40 parts by weight, and more preferably 5 to 20 parts by weight More preferably, but not exclusively.

The French shoreline bark extract contained in the composition may be contained in an amount of 0.001 to 99.9 parts by weight based on 100 parts by weight of the composition, preferably in an amount of 0.1 to 20 parts by weight, more preferably 0.5 to 5 parts by weight , But is not limited thereto.

The health food composition of the present invention may contain, in addition to the above-mentioned extracts, a known natural substance or compound known to have male sexual function improving effect so as to enhance or enhance male sexual function.

The composition of the present invention may contain sweeteners, flavors, physiologically active ingredients, minerals, processing aids, etc. in addition to red ginseng extract, octacosanol, Omija extract, Sasao extract, bokbunja extract, maca extract, leek extract and French coastal bark extract .

Sweetening agents may be used in an amount that sweetens the food in a suitable manner, and may be natural or synthetic. Preferably, natural sweeteners are used. Examples of natural sweeteners include sugar sweeteners such as corn syrup solids, honey, sucrose, fructose, lactose and maltose.

Flavors may be used to enhance taste or flavor, both natural and synthetic. Preferably, a natural one is used. When using natural ones, the purpose of nutritional fortification can be performed in addition to the flavor. Examples of natural flavoring agents include those obtained from apples, lemons, citrus fruits, grapes, strawberries, peaches, and the like, or those obtained from green tea leaves, Asiatica, Daegu, Cinnamon, Chrysanthemum leaves and Jasmine. Also, those obtained from ginseng (red ginseng), bamboo shoots, aloe vera, banks and the like can be used. The natural flavoring agent may be a liquid concentrate or a solid form of extract. Synthetic flavoring agents may be used depending on the case. Synthetic flavoring agents such as esters, alcohols, aldehydes and terpenes may be used.

Examples of the physiologically active substance include catechins such as catechin, epicatechin, gallocatechin and epigallocatechin, and vitamins such as retinol, ascorbic acid, tocopherol, calciferol, thiamine and riboflavin.

As the mineral, calcium, magnesium, chromium, cobalt, copper, fluoride, germanium, iodine, iron, lithium, magnesium, manganese, molybdenum, phosphorus, potassium, selenium, silicon, sodium, sulfur, vanadium and zinc can be used.

Processing aids may include raw materials which are useful for tabletting, which are conventionally used in tablet formulations, depending on the purpose of use, such as binders, coating agents, disintegrants, lubricants and the like.

In addition, the composition of the present invention may contain preservatives, emulsifiers, acidifiers, thickeners, and the like in addition to the above sweeteners.

Such preservatives, emulsifiers and the like are preferably added in a very small amount as long as they can attain an application to which they are added. The term " trace amount " means, when expressed numerically, in the range of 0.0005% by weight to about 0.5% by weight based on the total weight of the food composition.

Examples of the preservative which can be used include calcium sodium sorbate, sodium sorbate, potassium sorbate, calcium benzoate, sodium benzoate, potassium benzoate and EDTA (ethylenediaminetetraacetic acid).

Examples of the emulsifier which can be used include acacia gum, carboxymethyl cellulose, xanthan gum, pectin and the like.

Examples of the acidulant that can be used include citric acid, malic acid (malic acid), fumaric acid, adipic acid, phosphoric acid, gluconic acid, tartaric acid, ascorbic acid, acetic acid, and phosphoric acid. Such an acidulant may be added so that the food composition has a proper acidity for the purpose of inhibiting the growth of microorganisms other than the purpose of enhancing the taste.

Agents that may be used include suspending agents, sedimentation inhibitors, gel formers, bulking agents and the like.

Hereinafter, the present invention will be described in detail with reference to Examples and Experimental Examples.

However, the following examples and experimental examples are provided only for illustrating the present invention, and the content of the present invention is not limited by the following examples and experimental examples.

< Example  1> red ginseng concentrate powder, plant mixture extract powder, Maca  Extract powder, leek juice powder or French coast bark  Preparation of extract powder.

<1-1> Preparation of Red Ginseng Powder

The red ginseng concentrate contains conventional extracted extracts known in the art. In this experiment, 1 kg of red ginseng was added with 10 times of water, extracted at 85 ± 5 ° C for 10 ± 2 hours, centrifuged at a low temperature and concentrated under reduced pressure 120 g of concentrated red ginseng was obtained. The obtained red ginseng concentrate was dried and pulverized.

<1-2> Preparation of plant mixture extract powder

The plant mixed extract powder containing omija, sasu and bokbunja extracts was a plant mixed extract powder (biorland) containing commercially available omija, huasuo and bokbunja extracts.

Alternatively, a plant mixture extract powder containing an extract of Omija, Sasao and Bokbunja was prepared and used. Specifically, the process for producing a plant mixture extract powder containing an extract of Omija, Sasao and Rubus corea is as follows. 8 kg of water was added to the mixture, and the mixture was extracted at 85 ± 5 ° C for 10 ± 2 hours. The mixture was centrifuged at a low temperature and concentrated under reduced pressure 100 g of plant-mixed extract (solid content 10% content) was obtained. The weight ratio of the obtained extract to dextrin was 99: 1, and the mixture was dried and powdered.

&Lt; 1-3 > Omiza extract powder, Sewage  Preparation of extract powder or bokbunja extract powder

The production of Omiza extract powder, Sassoo extract powder or Bokbunja extract powder is as follows. The extracts of Omija, Hassuo or Bokbunja were obtained by the same extraction method as in the preparation of the plant mixture extract powder of Example 1-2, and the extracts (each having a solid content of 10% content) were mixed so that the weight ratio of the obtained extract to dextrin was 99: Dextrin was added to the extract, mixed and dried to prepare powder of each extract.

<1-4> Maca  Preparation of extract powder

1 kg of maca was prepared, and 8 times of water was added to the mixture, followed by extraction at 85 ± 5 ° C for 10 ± 2 hours. The mixture was centrifuged at low temperature and concentrated under reduced pressure to obtain 100 g of maca extract. The mixture was mixed so that the weight ratio of maca extract to maltodextrin was 24:76, followed by drying and pulverization. Or commercially available maca extract powder (NATUREX INC) was used.

<1-5> Leek Juice  Preparation of powder

1 kg of leek was squeezed by a juice extractor, and the mixture was mixed so that the weight ratio of the obtained leek juice to maltodextrin was 85:15, followed by drying and pulverization.

< Manufacturing example  1> red ginseng concentrate, Octacosanol , Omija extract, Sewage  Extract, bramble extract, Maca  Extract, leek Juice  And French coast bark  Preparation of a composition comprising an extract.

The extracts contained in the composition were mixed at the following ratio by weight based on 100 parts by weight of the composition: 40 to 60 parts by weight of the red ginseng concentrate powder of Example 1, 0.5 to 7 parts by weight of octacanol (ZXCHEM USA INC) 1 to 20 parts by weight of a plant mixture extract powder (biorand) containing a berry extract and 5 to 20 parts by weight of a maca extract powder (NATUREX INC), 5 to 20 parts by weight of a leek juice powder (predecessor) 0.5 to 5 parts by weight of peel extract powder (NATUREX INC).

< Experimental Example  1> Manufacturing example  1 &lt; / RTI &gt;

In order to confirm whether the composition of Preparation Example 1 had male sexual function improving effect, 163 men aged 40 to 69 years, whose sexual functions were weakened and whose activity for improving erectile dysfunctional sexual activity was improved, were administered with the composition of Preparation Example 1 (Table 1). In the preliminary survey, 61 of the subjects were dissatisfied with sex life. Specifically, the composition of Preparation Example 1 was administered 1400 mg twice a day for 1 month, and after 1 month, the sexual satisfaction, self-confidence, and physical changes were examined.

age 40-49 years 50-59 years 60-69 years Number of subjects (persons) 54 54 55

As a result, 81.6% of the subjects of the study group answered that they were helpful in the improvement of sexual function after taking the composition of the preparation example 1 for 1 month. Especially, in the case of the dissatisfied persons (61 persons) (Fig. 1). By age group, it was found that 87.0% in 40s, 85.2% in 50s, and 72.7% in 60s helped to improve sexual function (Fig. 1).

The number of sexual intercourse attempts and the duration of erection were 0.71 times, the actual number of intercourse times was 1.38 times, the duration of erection time was 2.14 minutes, the number of intercourse attempts was increased after taking the composition of preparation example 1 before taking the composition of preparation example 1, The number of attempts at sexual intercourse, number of actual intercourse, and duration of erection increased in all ages (Fig. 2). 13 major indicators, such as sexual desire, sexual satisfaction, sexual function, were also found to be improved when compared to before taking (Table 3).

In comparison with the response of 44.2% to the urge to libido, the sexual desire and urge incontinence after the composition of Preparation Example 1 was increased by 49.7% compared to that before the administration, and the composition of Preparation Example 1 The difference in the desire for sexual desire was 11.2%, which was the highest increase compared to other ages (Fig. 4).

Sexuality satisfaction was higher in all items than before the administration of the composition of Production Example 1 (Fig. 5).

Claims (2)

A health food composition containing red ginseng extract, octacosanol, Omija extract, Sasao extract, bokbunja extract, maca extract, leek extract and French coastal bark extract as effective ingredients. The method according to claim 1,
Wherein the composition comprises 40 to 60 parts by weight of the red ginseng extract, 0.5 to 7 parts by weight of the octacosanol, 2 to 7 parts by weight of the extract of Omija, 2 to 7 parts by weight of the extract of Hosuya, 5 to 20 parts by weight of the maca extract, 5 to 20 parts by weight of the leek extract, and 0.5 to 5 parts by weight of the French shoreline bark extract.

Images