KR20150022816A - N-에틸-4-하이드록실-1-메틸-5-(메틸(2,3,4,5,6-펜타하이드록시헥실)아미노)-2-옥소-n-페닐-1,2-디하이드로퀴놀린-3-카복스아미드 - Google Patents

N-에틸-4-하이드록실-1-메틸-5-(메틸(2,3,4,5,6-펜타하이드록시헥실)아미노)-2-옥소-n-페닐-1,2-디하이드로퀴놀린-3-카복스아미드 Download PDF

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Publication number
KR20150022816A
KR20150022816A KR20147034461A KR20147034461A KR20150022816A KR 20150022816 A KR20150022816 A KR 20150022816A KR 20147034461 A KR20147034461 A KR 20147034461A KR 20147034461 A KR20147034461 A KR 20147034461A KR 20150022816 A KR20150022816 A KR 20150022816A
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South Korea
Prior art keywords
methyl
pharmaceutical composition
pentahydroxyhexyl
carboxamide
ethyl
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English (en)
Korean (ko)
Inventor
아비탈 락세르
콘스탄틴 울라넨코
Original Assignee
테바 파마슈티컬 인더스트리즈 리미티드
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Publication of KR20150022816A publication Critical patent/KR20150022816A/ko
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR20147034461A 2012-05-08 2013-05-07 N-에틸-4-하이드록실-1-메틸-5-(메틸(2,3,4,5,6-펜타하이드록시헥실)아미노)-2-옥소-n-페닐-1,2-디하이드로퀴놀린-3-카복스아미드 Withdrawn KR20150022816A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261644054P 2012-05-08 2012-05-08
US61/644,054 2012-05-08
PCT/US2013/039911 WO2013169746A2 (en) 2012-05-08 2013-05-07 N-ethyl-4-hydroxyl-1-methyl-5-(methyl(2,3,4,5,6-pentahydroxyhexyl) amino)-2-oxo-n-phenyl-1,2-dihydroquinoline-3-carboxamide

Publications (1)

Publication Number Publication Date
KR20150022816A true KR20150022816A (ko) 2015-03-04

Family

ID=49551433

Family Applications (1)

Application Number Title Priority Date Filing Date
KR20147034461A Withdrawn KR20150022816A (ko) 2012-05-08 2013-05-07 N-에틸-4-하이드록실-1-메틸-5-(메틸(2,3,4,5,6-펜타하이드록시헥실)아미노)-2-옥소-n-페닐-1,2-디하이드로퀴놀린-3-카복스아미드

Country Status (19)

Country Link
US (1) US8809537B2 (https=)
EP (1) EP2697201A4 (https=)
KR (1) KR20150022816A (https=)
CN (1) CN104395291B (https=)
AR (1) AR090975A1 (https=)
AU (1) AU2013259779B2 (https=)
BR (1) BR112014028121A2 (https=)
CA (1) CA2873258A1 (https=)
EA (1) EA201492029A1 (https=)
HK (1) HK1207080A1 (https=)
IL (1) IL235338A0 (https=)
IN (1) IN2014MN02485A (https=)
MX (1) MX2014013664A (https=)
NZ (1) NZ630549A (https=)
SG (1) SG11201407447XA (https=)
TW (1) TW201350467A (https=)
UY (1) UY34791A (https=)
WO (1) WO2013169746A2 (https=)
ZA (1) ZA201408825B (https=)

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CN104093310A (zh) 2012-02-03 2014-10-08 泰华制药工业有限公司 拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途
JP6215238B2 (ja) 2012-02-16 2017-10-18 テバ ファーマシューティカル インダストリーズ リミティド Ｎ−エチル−ｎ−フェニル−１，２−ジヒドロ−４，５−ジ−ヒドロキシ−１−メチル−２−オキソ−３−キノリンカルボキサミド、その製剤、および使用
TW201400117A (zh) 2012-06-05 2014-01-01 Teva Pharma 使用拉喹莫德治療眼發炎疾病
TW201410244A (zh) 2012-08-13 2014-03-16 Teva Pharma 用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ）
EP2916915A4 (en) 2012-11-07 2016-06-22 Teva Pharma LAQUINIMOD AMINE SALTS
US20160046582A1 (en) 2013-03-14 2016-02-18 Teva Pharmaceutical Industries Ltd. Crystals of laquinimod sodium and improved process for the manufacture thereof
WO2015168103A1 (en) 2014-04-29 2015-11-05 Teva Pharmaceutical Industries Ltd. Laquinimod for the treatment of relapsing-remitting multiple sclerosis (rrms) patients with a high disability status

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SE8902076D0 (sv) 1989-06-09 1989-06-09 Pharmacia Ab Derivatives of quinoline-3-carboxanilide
US5139878A (en) 1991-08-12 1992-08-18 Allied-Signal Inc. Multilayer film constructions
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JP2012530701A (ja) 2009-06-19 2012-12-06 テバ ファーマシューティカル インダストリーズ リミティド 多発性硬化症のラキニモドでの治療
PL2458992T3 (pl) 2009-07-30 2016-07-29 Teva Pharma Leczenie choroby Leśniowskiego-Crohna z użyciem lakwinimodu
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EP2590653A4 (en) 2010-07-09 2014-01-01 Teva Pharma 5-CHLORO-4-HYDROXY-1-METHYL-2-OXO-N-PHENYL-1,2-DIHYDROCHINOLINE-3-CARBOXAMIDE, SALT THEREOF AND APPLICATIONS THEREOF
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Also Published As

Publication number Publication date
SG11201407447XA (en) 2015-02-27
AU2013259779B2 (en) 2017-06-08
WO2013169746A2 (en) 2013-11-14
EP2697201A4 (en) 2014-11-26
TW201350467A (zh) 2013-12-16
BR112014028121A2 (pt) 2017-06-27
UY34791A (es) 2013-11-29
CN104395291A (zh) 2015-03-04
US8809537B2 (en) 2014-08-19
AR090975A1 (es) 2014-12-17
ZA201408825B (en) 2016-07-27
NZ630549A (en) 2016-01-29
EA201492029A1 (ru) 2015-06-30
CA2873258A1 (en) 2013-11-14
HK1207080A1 (en) 2016-01-22
IL235338A0 (en) 2014-12-31
CN104395291B (zh) 2017-07-28
WO2013169746A3 (en) 2013-12-05
EP2697201A2 (en) 2014-02-19
US20130345256A1 (en) 2013-12-26
IN2014MN02485A (https=) 2015-07-17
MX2014013664A (es) 2015-04-17
AU2013259779A1 (en) 2014-12-18

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