KR20150021072A - 성장 호르몬 결핍의 치료에 있어서 hgh-xten 융합 단백질 및 이의 용도 - Google Patents
성장 호르몬 결핍의 치료에 있어서 hgh-xten 융합 단백질 및 이의 용도 Download PDFInfo
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- KR20150021072A KR20150021072A KR20147036167A KR20147036167A KR20150021072A KR 20150021072 A KR20150021072 A KR 20150021072A KR 20147036167 A KR20147036167 A KR 20147036167A KR 20147036167 A KR20147036167 A KR 20147036167A KR 20150021072 A KR20150021072 A KR 20150021072A
- Authority
- KR
- South Korea
- Prior art keywords
- xten
- hgh
- fusion protein
- sequence
- dose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
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| US201261689390P | 2012-06-05 | 2012-06-05 | |
| US61/689,390 | 2012-06-05 | ||
| US201261663475P | 2012-06-22 | 2012-06-22 | |
| US61/663,475 | 2012-06-22 | ||
| US201361763753P | 2013-02-12 | 2013-02-12 | |
| US61/763,753 | 2013-02-12 | ||
| PCT/US2013/031673 WO2013184216A1 (en) | 2012-06-05 | 2013-03-14 | Hgh-xten fusion protein and its use in the treatment of growth hormone deficiency |
Publications (1)
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| KR20150021072A true KR20150021072A (ko) | 2015-02-27 |
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| JP (2) | JP2015520188A (enExample) |
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| PH (1) | PH12014502738A1 (enExample) |
| SG (1) | SG11201408152VA (enExample) |
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Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7855279B2 (en) | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
| SI2393828T1 (sl) | 2009-02-03 | 2017-01-31 | Amunix Operating Inc. | Podaljšani rekombinantni polipetidi in sestavki, ki jih obsegajo |
| US9849188B2 (en) | 2009-06-08 | 2017-12-26 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
| HK1216617A1 (zh) * | 2013-03-11 | 2016-11-25 | Amunix Operating Inc. | 用人生长激素类似物治疗小儿生长激素缺乏症 |
| IL319047A (en) | 2015-08-28 | 2025-04-01 | Amunix Operating Inc | Chimeric polypeptide composition and methods for its preparation and use |
| WO2017136583A1 (en) | 2016-02-02 | 2017-08-10 | Versartis, Inc. | Growth hormone treatment adherence system |
| WO2017142331A1 (en) * | 2016-02-17 | 2017-08-24 | Genexine, Inc. | Pharmaceutical composition comprising recombinant hgh for the treatment of growth hormone deficiency |
| US12233113B2 (en) * | 2016-02-17 | 2025-02-25 | Genexine, Inc. | Pharmaceutical composition comprising recombinant hGH for the treatment of growth hormone deficiency |
| JP2019525931A (ja) * | 2016-07-27 | 2019-09-12 | アムニクス ファーマシューティカルズ， インコーポレイテッド | ヒト成長ホルモンアナログによる成人成長ホルモン欠乏症の処置 |
| JOP20190019A1 (ar) | 2016-08-30 | 2019-02-12 | Genexine Inc | تركيبة صيدلانية لعلاج نقص في هرمون نمو يحتوي على بروتين اندماجي لهرمون نمو بشري (hGH) |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| JP2021507706A (ja) | 2017-12-21 | 2021-02-25 | アムニクス ファーマシューティカルズ， インコーポレイテッド | 放出セグメントおよびそれを含む結合組成物 |
| CN112218877B (zh) | 2018-08-27 | 2025-07-25 | 瑞泽恩制药公司 | 拉曼光谱在下游纯化中的应用 |
| WO2021136223A1 (en) | 2019-12-31 | 2021-07-08 | Beijing Ql Biopharmaceutical Co., Ltd. | Fusion proteins of glp-1 and gdf15 and conjugates thereof |
| CN115322794B (zh) | 2020-01-11 | 2025-09-19 | 北京质肽生物医药科技有限公司 | Glp-1和fgf21的融合蛋白的缀合物 |
| JP2023545684A (ja) | 2020-09-30 | 2023-10-31 | ベイジン キューエル バイオファーマシューティカル カンパニー，リミテッド | ポリペプチドコンジュゲートおよび使用の方法 |
| CN116554343B (zh) * | 2022-01-30 | 2024-07-12 | 领诺(上海)医药科技有限公司 | 一种长效重组人生长激素及其应用 |
| EP4323413A4 (en) | 2022-03-30 | 2025-10-15 | Beijing Ql Biopharmaceutical Co Ltd | LIQUID PHARMACEUTICAL COMPOSITIONS OF POLYPEPTIDE CONJUGATES AND METHODS OF USE THEREOF |
| CN116003632B (zh) * | 2022-12-07 | 2026-02-24 | 北京大学 | 长效缓释型人重组生长激素融合蛋白及其药物组合物和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4898830A (en) | 1979-07-05 | 1990-02-06 | Genentech, Inc. | Human growth hormone DNA |
| US5206161A (en) | 1991-02-01 | 1993-04-27 | Genentech, Inc. | Human plasma carboxypeptidase B |
| DE69833755T2 (de) | 1997-05-21 | 2006-12-28 | Biovation Ltd. | Verfahren zur herstellung von nicht-immunogenen proteinen |
| US6406632B1 (en) | 1998-04-03 | 2002-06-18 | Symyx Technologies, Inc. | Rapid characterization of polymers |
| GB9815157D0 (en) | 1998-07-13 | 1998-09-09 | Metron Designs Ltd | High resolution pulse width setting from relatively low frequency clocks |
| US20030228309A1 (en) | 2000-11-08 | 2003-12-11 | Theodora Salcedo | Antibodies that immunospecifically bind to TRAIL receptors |
| US6992174B2 (en) | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
| US7294513B2 (en) | 2002-07-24 | 2007-11-13 | Wyatt Technology Corporation | Method and apparatus for characterizing solutions of small particles |
| US8680050B2 (en) * | 2009-02-03 | 2014-03-25 | Amunix Operating Inc. | Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same |
| US8703717B2 (en) * | 2009-02-03 | 2014-04-22 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
| SI2393828T1 (sl) * | 2009-02-03 | 2017-01-31 | Amunix Operating Inc. | Podaljšani rekombinantni polipetidi in sestavki, ki jih obsegajo |
| JP5805634B2 (ja) * | 2009-06-08 | 2015-11-04 | アムニクス オペレーティング インコーポレイテッド | 成長ホルモンポリペプチド並びにその作成及び使用方法 |
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- 2013-03-14 BR BR112014030404A patent/BR112014030404A2/pt not_active IP Right Cessation
- 2013-03-14 MX MX2014014927A patent/MX2014014927A/es unknown
- 2013-03-14 US US13/829,369 patent/US20140162949A1/en not_active Abandoned
- 2013-03-14 KR KR20147036167A patent/KR20150021072A/ko not_active Withdrawn
- 2013-03-14 AU AU2013272220A patent/AU2013272220A1/en not_active Abandoned
- 2013-03-14 CA CA2875827A patent/CA2875827A1/en not_active Abandoned
- 2013-03-14 NZ NZ702557A patent/NZ702557A/en not_active IP Right Cessation
- 2013-03-14 CN CN201380041556.9A patent/CN104519903A/zh active Pending
- 2013-03-14 EP EP13712656.1A patent/EP2858664B1/en active Active
- 2013-03-14 SG SG11201408152VA patent/SG11201408152VA/en unknown
- 2013-03-14 JP JP2015516010A patent/JP2015520188A/ja active Pending
- 2013-03-14 CN CN201710596161.5A patent/CN107320719A/zh not_active Withdrawn
- 2013-03-14 ES ES13712656T patent/ES2733220T3/es active Active
- 2013-03-14 HK HK15109368.8A patent/HK1208629A1/xx unknown
- 2013-03-14 WO PCT/US2013/031673 patent/WO2013184216A1/en not_active Ceased
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- 2014-12-05 PH PH12014502738A patent/PH12014502738A1/en unknown
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2017
- 2017-03-08 JP JP2017043512A patent/JP2017125051A/ja active Pending
- 2017-07-13 US US15/648,967 patent/US20180051063A1/en not_active Abandoned
Also Published As
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| HK1208629A1 (en) | 2016-03-11 |
| DK2858664T3 (da) | 2019-07-08 |
| WO2013184216A1 (en) | 2013-12-12 |
| JP2017125051A (ja) | 2017-07-20 |
| EP2858664B1 (en) | 2019-05-08 |
| MX2014014927A (es) | 2015-05-15 |
| CN104519903A (zh) | 2015-04-15 |
| AU2013272220A1 (en) | 2015-01-15 |
| US20140162949A1 (en) | 2014-06-12 |
| EP2858664A1 (en) | 2015-04-15 |
| CA2875827A1 (en) | 2013-12-12 |
| US20180051063A1 (en) | 2018-02-22 |
| ES2733220T3 (es) | 2019-11-28 |
| PH12014502738A1 (en) | 2015-02-02 |
| BR112014030404A2 (pt) | 2017-06-27 |
| CN107320719A (zh) | 2017-11-07 |
| JP2015520188A (ja) | 2015-07-16 |
| NZ702557A (en) | 2017-06-30 |
| IL236070A0 (en) | 2015-01-29 |
| SG11201408152VA (en) | 2015-01-29 |
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